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"Persistent pain"

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https://www.readbyqxmd.com/read/28087677/incorporating-persistent-pain-in-phenotypic-frailty-measurement-and-prediction-of-adverse-health-outcomes
#1
Matthew C Lohman, Karen L Whiteman, Rebecca L Greenberg, Martha L Bruce
BACKGROUND: Frailty, a syndrome of physiological deficits, is prevalent among older adults and predicts elevated risk of adverse health outcomes. Although persistent pain predicts similar risk, it is seldom considered in frailty measurement. This article evaluated the construct and predictive validity of including persistent pain in phenotypic frailty measurement. METHODS: Frailty and persistent pain were operationalized using data from the Health and Retirement Study (2006-2012 waves)...
February 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28073868/delayed-diagnosis-of-fractured-anterior-arch-of-the-atlas-in-a-young-child
#2
Sergio B Sesia, Friederike Prüfer, Michael Walther, Daniel Studer
A 2-year-old girl fell off a bunk bed onto a parquet floor. She immediately reported neck pain and presented with muscle spasm and limited motion of the cervical spine (C-spine). Plain X-rays of the C-spine showed no osseous lesion. Owing to persisting pain and limited motion in the neck, MRI of the C-spine was obtained which revealed intact ligaments and cervical spinal cord, as well as soft tissue swelling in front of the anterior arch of the atlas. Subsequent CT of the C-spine confirmed a complete, undisplaced fracture of the anterior arch of the atlas (Gehweiler type I fracture)...
January 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28072604/epigenetic-upregulation-of-cxcl12-expression-mediates-anti-tubulin-chemotherapeutics-induced-neuropathic-pain
#3
Ting Xu, Xiao-Long Zhang, Han-Dong Ou-Yang, Zhen-Yu Li, Cui-Cui Liu, Zhen-Zhen Huang, Jing Xu, Jia-You Wei, Bi-Lin Nie, Chao Ma, Shao-Ling Wu, Wen-Jun Xin
Clinically, Microtubule-targeted agents-induced neuropathic pain hampers chemotherapeutics for cancer patients. Here, we found that application of paclitaxel or vincristine increased the protein and mRNA expression of CXCL12, and frequency and amplitude of miniature excitatory post synaptic currents (mEPSCs) in spinal dorsal horn neurons. Spinal local application of CXCL12 induced the long-term potentiation (LTP) of nociceptive synaptic transmission and increased the amplitude of mEPSCs. Inhibition of CXCL12 by using the transgenic mice (CXCL12) or neutralizing antibody or siRNA ameliorated the mEPSCs enhancement and mechanical allodynia...
January 7, 2017: Pain
https://www.readbyqxmd.com/read/28069928/functional-organization-of-cutaneous-and-muscle-afferent-synapses-onto-immature-spinal-lamina-i-projection-neurons
#4
Jie Li, Mark L Baccei
: It is well-established that sensory afferents innervating muscle are more effective at inducing hyperexcitability within spinal cord circuits compared to skin afferents, which likely contributes to the higher prevalence of chronic musculoskeletal pain compared to pain of cutaneous origin. However, the mechanisms underlying these differences in central nociceptive signaling remain incompletely understood, as nothing is known about how superficial dorsal horn (SDH) neurons process sensory input from muscle vs...
January 9, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28067693/intraoperative-ketamine-reduces-immediate-postoperative-opioid-consumption-after-spinal-fusion-surgery-in-chronic-pain-patients-with-opioid-dependency-a-randomized-blinded-trial
#5
Rikke Vibeke Nielsen, Jonna Storm Fomsgaard, Hanna Siegel, Robertas Martusevicius, Lone Nikolajsen, Jørgen Berg Dahl, Ole Mathiesen
Perioperative handling of surgical patients with opioid dependency represents an important clinical problem. Animal studies suggest that ketamine attenuates central sensitization and hyperalgesia and thereby reduces postoperative opioid tolerance. We hypothesized that intraoperative ketamine would reduce immediate postoperative opioid consumption compared to placebo in chronic pain patients with opioid dependency undergoing lumbar spinal fusion surgery. Primary outcome was morphine consumption 0-24 h postoperatively...
January 6, 2017: Pain
https://www.readbyqxmd.com/read/28064244/recurrence-of-an-intra-articular-osteoid-osteoma-of-the-great-toe-a-case-report-and-review-of-the-literature
#6
Josep Torrent, Alberto Bailez, Jordi Asuncion
Osteoid osteoma (OO) is a benign tumor that it is not generally seen in the foot and even less frequently in the phalanx (2-4%). The diagnosis when its location is intra-articular is a challenge and often delayed because the symptoms mimic a real arthritis. We report a clinical case involving a 16-year-old male patient who complained of persistent pain of the interphalangeal joint (IPJ) of the left hallux. A juxta-articular OO of the condyle of the proximal phalanx was identified. The patient underwent surgery that included tumor removal preserving the articular cartilage...
January 6, 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28053634/persistent-pain-after-breast-cancer-treatment-a-questionnaire-based-study-on-the-prevalence-associated-treatment-variables-and-pain-type
#7
Alexander Andersen Juhl, Peer Christiansen, Tine Engberg Damsgaard
PURPOSE: Persistent pain is a common side effect of breast cancer treatment. The present study aimed to assess the prevalence, associated treatment-related factors, and the type of pain (neuropathic or nociceptive) in patients who had undergone a unilateral mastectomy. METHODS: All women who underwent a unilateral mastectomy at a University Hospital between 2009 and 2013 were eligible for inclusion. Women with breast reconstruction or active cancer were excluded...
December 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28050640/is-the-humeral-stem-useful-in-anatomic-total-shoulder-arthroplasty
#8
Philippe Collin, Tetsu Matsukawa, Pascal Boileau, Ulrich Brunner, Gilles Walch
PURPOSE: Traditionally and since Neer, the humeral side of shoulder arthroplasty consisted of a stemmed component but the real need for stem fixation in total shoulder arthroplasty (TSA) has barely been investigated. The current study evaluated the clinical and radiological outcomes with a stemless TSA. METHODS: Forty-seven patients, 20 female and 27 male patients with an average age of 63, were selected in four orthopaedic centres during a four year period, and implanted with a humeral head prosthesis with a three-fin design and titanium coating...
January 3, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28045713/differentiating-hip-pathology-from-lumbar-spine-pathology-key-points-of-evaluation-and-management
#9
Aaron J Buckland, Ryan Miyamoto, Rakesh D Patel, James Slover, Afshin E Razi
The diagnosis and treatment of patients who have both hip and lumbar spine pathologies may be a challenge because overlapping symptoms may delay a correct diagnosis and appropriate treatment. Common complaints of patients who have both hip and lumbar spine pathologies include low back pain with associated buttock, groin, thigh, and, possibly, knee pain. A thorough patient history should be obtained and a complete physical examination should be performed in these patients to identify the primary source of pain...
December 29, 2016: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28041316/cyberknife-stereotactic-radiosurgery-for-the-treatment-of-symptomatic-vertebral-hemangiomas-a-single-institution-experience
#10
Michael Zhang, Yi-Ren Chen, Steven D Chang, Anand Veeravagu
OBJECTIVE Symptomatic vertebral hemangiomas (SVHs) are a very rare pathology that can present with persistent pain or neurological deficits that warrant surgical intervention. Given the relative rarity and difficulty in assessment, the authors sought to present a dedicated series of SVHs treated using stereotactic radiosurgery (SRS) to provide insight into clinical decision making. METHODS A retrospective review of a single institution's experience with hypofractionated radiosurgery for SVH from 2004 to 2011 was conducted to determine the clinical and radiographic outcomes following SRS treatment...
January 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28039101/increasing-optimism-protects-against-pain-induced-impairments-in-task-shifting-performance
#11
Jantine J L M Boselie, Linda M G Vancleef, Madelon L Peters
: Persistent pain can lead to difficulties in executive task performance. Three core executive functions that are often postulated are inhibition, updating and shifting. Optimism, the tendency to expect that good things happen in the future, has been shown to protect against pain-induced performance deterioration in the executive function updating. This study tested whether this protective effect of a temporary optimistic state by means of a writing and visualization exercise extended to the executive function shifting...
December 27, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28038992/functional-and-ultrasonographic-outcomes-after-surgical-fibular-tendon-stabilisation-by-isolated-re-tensioning-of-the-superior-fibular-retinaculum
#12
C Choufani, R Rousseau, A Massein, H Pascal-Mousselard, F Khiami
BACKGROUND: Fibular tendon dislocation is a rare and usually sports-related injury. We report the functional and ultrasonographic outcomes of a simple technique for re-tensioning the superior fibular retinaculum. HYPOTHESIS: Our retinaculum re-tensioning technique is not followed by recurrent fibular tendon dislocation, as demonstrated by ultrasonography. MATERIAL AND METHOD: This single-centre single-surgeon retrospective study included 17 patients who underwent surgery to treat fibular tendon dislocation between January 2008 and December 2013...
December 27, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28034972/the-association-between-musculoskeletal-pain-and-circulating-ornithine-a-population-based-study
#13
Pekka Mäntyselkä, Toni Ali-Sisto, Hannu Kautiainen, Leo Niskanen, Heimo Viinamäki, Vidya Velagapudi, Soili M Lehto
OBJECTIVE:  Based on several previous clinical studies, we hypothesized that ornithine levels are different among subjects with persistent musculoskeletal pain compared with other subjects in the population. DESIGN:  The study sample consisted of 221 adults with nonpersistent pain, 76 with persistent pain, and 61 with no pain. Concentrations of glutamic acid, ornithine, citrulline, arginine, proline, and spermidine were analyzed using a mass spectrometer. SETTING:  Lapinlahti municipality in Finland...
December 29, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28030858/reviewing-patients-following-mesh-repair-the-benefits
#14
Claudia R Kowalik, M M E Lakeman, Josephine E Oryszczyn, Jan Paul W R Roovers
BACKGROUND/AIMS: The use of synthetic mesh implants for vaginal prolapse surgery is still a subject of debate due to safety concerns. We aimed to explore long-term complications of all women treated with mesh surgery for pelvic organ prolapse (POP) in our centre. METHODS: This is a cross-sectional study of 188 women who underwent vaginal mesh surgery in a Dutch University Hospital between 2007 and 2012. The prevalence of mesh exposure, pain symptoms and patient satisfaction has been documented...
December 29, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28029722/taste-function-assessed-by-electrogustometry-in-burning-mouth-syndrome-a-case-control-study
#15
Adeline Braud, Vianney Descroix, Marie-Noëlle Ungeheuer, Catherine Rougeot, Yves Boucher
OBJECTIVE: Idiopathic Burning mouth syndrome (iBMS) is characterized by oral persistent pain without any clinical or biological abnormality. The aim of the present study was to evaluate taste function in iBMS subjects and healthy controls. MATERIAL AND METHODS: Electrogustometric thresholds (EGMt) were recorded in 21 iBMS patients and 21 paired matched controls at nine loci of the tongue assessing fungiform and foliate gustatory papillae function. Comparison of EGMt was performed using the non-parametric Wilcoxon signed-rank test...
December 28, 2016: Oral Diseases
https://www.readbyqxmd.com/read/28029533/unexplained-pain-post-total-knee-arthroplasty-with-an-oxford-knee-score-%C3%A2-20-at-6-months-predicts-good-2-year-outcome
#16
Renyi Benjamin Seah, Winston Shang Rong Lim, Ngai Nung Lo, Andy Khye Soo Yew, Hwei Chi Chong, Seng Jin Yeo
BACKGROUND: Total knee arthroplasty (TKA) is an effective procedure for end-stage osteoarthritis of the knee. Some patients experience persistent unexplained pain post-TKA despite normal investigations. The purpose of this study is to identify which of these patients are likely to improve without any surgical intervention. We hypothesize that patients with unexplained persistent pain and a poor 6-month Oxford knee score (OKS) post-TKA can improve at 2 years. METHODS: Prospectively collected data for all primary unilateral TKA performed from June 2004 to January 2012 were analyzed to identify which patients with unexplained pain at 6 months will improve at 2 years...
October 4, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28025356/graded-activity-for-older-adults-with-chronic-low-back-pain-program-development-and-mixed-methods-feasibility-cohort-study
#17
Katrin Kuss, Corinna Leonhardt, Sabine Quint, Dagmar Seeger, Michael Pfingsten, Udo Wolf Pt, Heinz-Dieter Basler, Annette Becker
BACKGROUND: Persistent pain is highly prevalent in older adults and can lead to functional limitations in activities of daily living, and to psychosocial distress. There is a lack of established active therapy programs, especially for older adults with chronic pain. OBJECTIVES: To develop a graded activity program and to evaluate its feasibility within a pilot study. DESIGN: Phase I/phase II trial of a complex intervention. A mixed methods design was chosen to evaluate the feasibility, acceptability, and preliminary evidence of effectiveness...
December 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28025352/chronic-whiplash-associated-disorders-wad-responses-to-nerve-blocks-of-cervical-zygapophyseal-joints
#18
Mats Persson, Jan Sörensen, Björn Gerdle
OBJECTIVE: This study explores the prevalence of facet joint pain in chronic Whiplash Associated Disorder (WAD). DESIGN: Forty-seven patients with chronic WAD were scheduled for medial branch blocks of the cervical spine. METHODS: The patient's localization of the pain together with established pain maps guided to the first level of zygapophyseal joint to be tested. The joint was anesthetized by injecting bupivacaine (0.5 ml; 5 mg/ml) to the medial branches of the cervical dorsal rami above and below the joint...
December 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28007392/donor-site-morbidity-and-quality-of-life-after-microvascular-head-and-neck-reconstruction-with-free-fibula-and-deep-circumflex-iliac-artery-flaps
#19
Christopher Schardt, Angela Schmid, Jens Bodem, Johannes Krisam, Jürgen Hoffmann, Christian Mertens
PURPOSE: Bone defects after resective tumor surgeries often require the use of microvascular reanastomized bone grafts for reconstruction. The decision as to which specific flap is most suitable for the particular patient is dependent on various factors. The aspects donor site morbidity and quality of life are rarely taken into account in this connection. The aim of this study was to analyze whether these factors, in the future, should influence the choice of donor site. MATERIAL AND METHODS: In this study, the donor sites of 46 patients with respect to deep-circumflex iliac artery (DCIA) and fibula flaps were analyzed using subjective and objective parameters...
November 30, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28005142/no-correlation-between-coronal-alignment-of-total-knee-arthroplasty-and-clinical-outcomes-a-prospective-clinical-study-using-3d-ct
#20
Omer Slevin, Felix Amsler, Michael T Hirschmann
PURPOSE: The aim of this study was to evaluate femoral and tibial as well as whole leg coronal TKA alignment using 3D-reconstructed CTs and to assess the relationship of coronal TKA alignment and clinical outcome in a large prospective series of patients. It was hypothesized that a coronal deviation of TKA position and leg alignment from the mechanical axis is correlated with poorer patients' outcome after TKA. METHODS: A total of 81 consecutive patients who underwent primary TKA were prospectively included...
December 22, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
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