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"Persistent pain"

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https://www.readbyqxmd.com/read/28733130/a-pilot-randomized-controlled-trial-on-the-effects-of-a-progressive-exercise-program-on-the-range-of-motion-and-upper-extremity-grip-strength-in-young-adults-with-breast-cancer
#1
Marize Ibrahim, Thierry Muanza, Nadia Smirnow, Warren Sateren, Beatrice Fournier, Petr Kavan, Michael Palumbo, Richard Dalfen, Mary-Ann Dalzell
BACKGROUND: The diagnosis of breast cancer in young women (aged 18-45 years) has been increasing. Women are commonly left coping with treatment-related disabilities of the upper limb that can persist for > 2 years postoperatively. PATIENTS AND METHODS: A total of 59 young breast cancer patients (29 in the intervention group and 30 in the control group) participated in a pilot prospective randomized controlled trial to determine whether a 12-week postradiation exercise program would improve long-term arm mobility, pain, and handgrip strength...
June 24, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28732166/mel-n16-a-series-of-novel-endomorphin-analogs-with-good-analgesic-activity-and-a-favorable-side-effect-profile
#2
Xin Liu, Long Zhao, Yuan Wang, Jingjing Zhou, Dan Wang, Yixin Zhang, Xianghui Zhang, Zhaojuan Wang, Dongxu Yang, Lingyun Mou, Rui Wang
Opioid peptides are neuromodulators that bind to opioid receptors and reduce pain sensitivity. Endomorphins are one of the most active endogenous opioid peptides, and they have good affinity and selectivity toward the μ opioid receptor. However, their clinical usage is hindered by their inability to cross the blood-brain barrier, and their poor in vivo activity after peripheral injection. In order to overcome these defects, we have designed and synthesized a series of novel endomorphin analogs with multiple site modifications...
July 21, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28729113/activation-of-rage-stat3-pathway-by-methylglyoxal-contributes-to-spinal-central-sensitization-and-persistent-pain-induced-by-bortezomib
#3
Jia-You Wei, Cui-Cui Liu, Han-Dong Ouyang, Chao Ma, Man-Xiu Xie, Meng Liu, Wan-Long Lei, Huan-Huan Ding, Shao-Ling Wu, Wen-Jun Xin
Bortezomib is a first-line chemotherapeutic drug widely used for multiple myeloma and other nonsolid malignancies. Although bortezomib-induced persistent pain is easily diagnosed in clinic, the pathogenic mechanism remains unclear. Here, we studied this issue with use of a rat model of systemic intraperitoneal administration of bortezomib for consecutive 5days. Consisted with our previous study, we found that bortezomib treatment markedly induced mechanical allodynia in rats. Furthermore, we first found that bortezomib treatment significantly induced the upregulation of methylglyoxal in spinal dorsal horn of rats...
July 18, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28728063/factors-associated-with-non-return-to-work-in-the-severely-injured-victims-3-years-after-a-road-accident-a-prospective-study
#4
C Pélissier, E Fort, L Fontana, B Charbotel, M Hours
Road accidents may impact victims' physical and/or mental health and socio-occupational life, particularly the capacity to return to work. The purpose of our study is to assess modifiable medical and socio-occupational factors of non-return to work in the severely injured 3 years after a road accident. Among1,168 road accidents casualties in the Rhône administrative Département of France followed for five years, 141 of the 222 severely injured (Maximal Abbreviated Injury Scale ≥ 3) aged more than 16 years who were in work at the time of the accident, reported whether they had returned to work in the 3 years following the accident...
July 17, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28727711/high-body-mass-index-is-a-potential-risk-factor-for-persistent-postoperative-pain-after-breast-cancer-treatment
#5
Noud van Helmond, Hans Timmerman, Nick T van Dasselaar, Carmen C van de Pol, Soren S Olesen, Asbjorn M Drewes, Kris Vissers, Oliver H Wilder-Smith, Monique A Steegers
BACKGROUND: Risk factors associated with persistent pain after breast cancer treatment are needed to develop prevention and treatment strategies to improve the quality of life for patients with breast cancer. OBJECTIVES: To identify factors associated with persistent pain in women undergoing breast cancer treatments. STUDY DESIGN: Retrospective study. SETTING: Regional hospital in the Netherlands. METHODS: The primary outcome was pain associated with surgery at more than 6 months postoperatively and patients were stratified based on the associated visual analog" scale score they reported: reporting no pain as "no pain," pain 1 - 29 mm as "mild pain," and pain 30 - 100 mm as "moderate/severe pain...
July 2017: Pain Physician
https://www.readbyqxmd.com/read/28727705/activation-of-the-rage-stat3-pathway-in-the-dorsal-root-ganglion-contributes-to-the-persistent-pain-hypersensitivity-induced-by-lumbar-disc-herniation
#6
Xin-Sheng Zhang, Xiao Li, Hai-Jie Luo, Zhu-Xi Huang, Cui-Cui Liu, Qing Wan, Shu-Wei Xu, Shao-Ling Wu, Song-Jian Ke, Chao Ma
BACKGROUND: Clinically, chronic low back pain and sciatica associated with lumbar disc herniation (LDH) is a common musculoskeletal disorder. Due to the unawareness of detailed mechanisms, it is difficult to get an effective therapy. OBJECTIVE: The aim of the present study was to identify the role of the RAGE/STAT3 pathway in the dorsal root ganglion (DRG) on the formation and development of persistent pain hypersensitivity induced by LDH. STUDY DESIGN: Controlled animal study...
July 2017: Pain Physician
https://www.readbyqxmd.com/read/28723758/total-knee-arthroplasty-conversion-after-a-failed-lateral-closing-wedge-high-tibial-osteotomy-with-knee-hyperextension-and-secondary-ankle-degeneration-a-case-report
#7
Chen Yao, Xingquan Xu, Sheng Zhou, Xiaoxiao Song, Dongquan Shi, Qing Jiang
RATIONALE: High tibial osteotomy (HTO) has been used widely for medial compartment knee osteoarthritis to correct the deformity and relieve symptoms, especially in young patients who are willing to maintain the high activity level. However, the change of bone morphology, ligament imbalance, limb malalignment, and other complications may influence the short-term outcomes of HTO. Some cases may even require conversion to TKA shortly after HTO because of the loss of correction or pain due to accelerated osteoarthritis...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28723371/complications-of-transvaginal-mesh-for-pelvic-organ-prolapse-and-stress-urinary-incontinence-tips-for-prevention-recognition-and-management
#8
REVIEW
Susan MacDonald, Ryan Terlecki, Elisabetta Costantini, Gopal Badlani
CONTEXT: Mesh-related complications following transvaginal management of pelvic organ prolapse (POP) and/or stress urinary incontinence (SUI) have received significant attention in the last decade. OBJECTIVE: We sought to identify patient, product, and technical factors associated with an increased risk of complications after mesh-based transvaginal repair of anterior POP and SUI. In this review we clarify the different pattern of complications after POP and SUI repairs...
August 2016: European Urology Focus
https://www.readbyqxmd.com/read/28722116/opioids-for-cancer-related-pain-in-children-and-adolescents
#9
REVIEW
Philip J Wiffen, Tess E Cooper, Anna-Karenia Anderson, Andrew L Gray, Marie-Claude Grégoire, Gustaf Ljungman, Boris Zernikow
BACKGROUND: Pain is a common feature of childhood and adolescence around the world, and for many young people, that pain is chronic. The World Health Organization (WHO) guidelines for pharmacological treatments for children's persisting pain acknowledge that pain in children is a major public health concern of high significance in most parts of the world. Views on children's pain have changed over time and relief of pain is now seen as important. In the past, pain was largely dismissed and was frequently left untreated, and it was assumed that children quickly forgot about painful experiences...
July 19, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28716614/evaluation-of-a-pain-assessment-procedure-in-long-term-care-residents-with-pain-and-dementia
#10
Janine van Kooten, Martin Smalbrugge, Johannes C van der Wouden, Max L Stek, Cees M P M Hertogh
BACKGROUND: The management of pain in long-term care residents with dementia is complex. A prospective exploratory study was conducted to describe the course of pain and pain management strategies following a guideline-based pain assessment procedure in long-term care (LTC) residents with pain and dementia. MEASURES: Pain observations with the MOBID-2 Pain Scale, review of the medical records and pharmacy files and physical examination of LTC residents with pain and dementia...
July 14, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28712474/postherpetic-neuralgia-practical-experiences-return-to-traditional-chinese-medicine
#11
REVIEW
Majid Avijgan, Seyedeh Tahoora Hajzargarbashi, Aliasghar Kamran, Mahtab Avijgan
Post-herpetic neuralgia (PHN) is a complication of herpes zoster that can cause different types of pain in the affected area. It often occurs mainly in severe cases of herpes zoster. The problem is defined as a persisting pain for 90-120 days after relieving of acute phase of herpes lesions. This complication causes suffering in patients and reduces the quality of life. In western medicine's viewpoints, PHN is due to disturbance in local and dermatomal nerves. There are several topical and systemic drugs that are used to manage the pain relief...
June 2017: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/28709955/neonatal-injury-results-in-sex-dependent-nociceptive-hypersensitivity-and-social-behavioral-deficits-during-adolescence-without-altering-morphine-response
#12
Nikita N Burke, Tuan Trang
Neonatal injury is associated with persistent changes in sensory function and altered nociceptive thresholds that give rise to aberrant pain sensitivity in later life. While these changes are well documented in adult rodents, little is known about the consequences of neonatal injury during adolescence. Since adolescence is a critical developmental period during which persistent pain conditions can arise, we examined the impact of neonatal injury on nociception, social behavior and response to morphine in adolescent Sprague Dawley rats...
July 11, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28709613/a-regional-registry-study-of-216-patients-investigating-if-patient-satisfaction-after-total-knee-arthroplasty-changes-over-a-time-period-of-five-to-20years
#13
Odei Shannak, Jeya Palan, Colin Esler
AIMS: To determine the temporal changes in patient dissatisfaction following primary knee arthroplasty surgery (TKA). PATIENTS AND METHODS: Three hundred and ninety patients that had previously indicated they were either dissatisfied or unsure with their TKA at one-year post-surgery in our region were mailed a simple questionnaire in addition to the Oxford Knee Score and EQ-5D. RESULTS: A 55% response rate was achieved. The mean follow-up time period was 9...
August 2017: Knee
https://www.readbyqxmd.com/read/28706800/arthroscopic-screw-removal-after-arthroscopic-latarjet-procedure
#14
Thibault Lafosse, Lior Amsallem, Damien Delgrande, Antoine Gerometta, Laurent Lafosse
Arthroscopic Latarjet procedure is an efficient and reliable approach for the treatment of shoulder instability. Nevertheless, the screws fixing the bone block may sometimes be responsible for pain and uncomfortable snapping in the shoulder that is triggered during active external rotation. We propose an all-arthroscopic technique for screw removal in cases of complications involving the screws from a Latarjet procedure. The all-arthroscopic screw removal is reliable and efficient. This procedure is indicated in more cases than thought because of the bone block resorption...
June 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28706450/reactive-oxygen-species-increase-neuronal-excitability-via-activation-of-nonspecific-cation-channel-in-rat-medullary-dorsal-horn-neurons
#15
Hae In Lee, Byung Rim Park, Sang Woo Chun
The caudal subnucleus of the spinal trigeminal nucleus (medullary dorsal horn; MDH) receives direct inputs from small diameter primary afferent fibers that predominantly transmit nociceptive information in the orofacial region. Recent studies indicate that reactive oxygen species (ROS) is involved in persistent pain, primarily through spinal mechanisms. In this study, we aimed to investigate the role of xanthine/xanthine oxidase (X/XO) system, a known generator of superoxide anion (O2(·-)), on membrane excitability in the rat MDH neurons...
July 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28702394/osteoid-osteoma-radiofrequency-ablation-treatment-guided-by-computed-tomography-a-case-series
#16
Rosana Raquel Endo, Natalia Fabris Gama, Suely Akiko Nakagawa, Chiang Jeng Tyng, Wu Tu Chung, Fábio Fernando Eloi Pinto
The osteoid osteoma is a benign primary bone tumor that affects mainly males in the second and third decades of life. Radiographic findings show a radiolucent nidus surrounded by reactive sclerotic bone, particularly in the long bones of the lower extremity. Clinically, it presents persistent pain, which is worse at night and improves with salicylates. It can be a self-limiting injury, with an average duration of three years, but because of pain intensity and intolerance to prolonged use of nonsteroidal anti-inflammatories, surgical treatment is an option...
May 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28700361/persistent-pain-in-cancer-survivors
#17
Elaine G Boland, Sam H Ahmedzai
PURPOSE OF REVIEW: As people are living longer after a diagnosis and primary treatment for cancer, or indeed living with cancer as a chronic disease, new problems are emerging in this growing population of so-called 'survivors'. Persistent or chronic pain is one of the commonest complaints, arising from the tissue damage caused by the original neoplasm, consequences of surgery and other therapies, and - especially in older people - multimorbidity. This review explores some of the principle causes and mechanisms of this phenomenon and reviews the evidence for their management...
July 11, 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28699514/monoterpenes-as-perspective-to-chronic-pain-management-a-systematic-review
#18
Daniele Nascimento Gouveia, Lícia Tairiny Santos Pina, Thallita Kelly Rabelo, Wagner Barbosa da Rocha Santos, Jullyana S S Quintans, Adriana Gibara Guimarães
BACKGROUND: Individuals with chronic diseases have persistent pain as the main symptom, which can often reduce their life quality and functional capacity. The suffering of patients results from the interaction of aversive perception of pain with physical disability, social and family isolation, financial worries and fear of mutilation and death. As an individual and subjective phenomenon that involves many complex aspects, chronic pain should be evaluated and treated in its various components...
July 11, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28699380/addressing-the-barriers-related-with-opioid-therapy-for-management-of-chronic-pain-in-india
#19
Gur Prasad Dureja, Paramanand N Jain, Muralidhar Joshi, Ashok Saxena, Gautam Das, Jaishid Ahdal, Prashant Narang
India has a high prevalence of chronic disorders which may be associated with persistent pain. Despite the availability of multiple treatment options, chronic pain is largely untreated and contributes to disability and mortality. Medical consumption of opioids remains low due to various barriers that prevent access to opioids for patients and healthcare practitioners. Stringent regulatory provisions outlined in the Narcotic Drugs and Psychotropic Substances Act (1985) have been major deterrents to adequate opioid use...
July 12, 2017: Pain Management
https://www.readbyqxmd.com/read/28695345/is-pain-relief-after-vaginal-mesh-and-or-sling-removal-durable-long-term
#20
Karen Jong, Shreeya Popat, Alana Christie, Philippe E Zimmern
INTRODUCTION AND HYPOTHESIS: This study was to review our experience of pain relief durability in women who experienced initial pain resolution after vaginal mesh and/or sling removal (VMSR). METHODS: A retrospective chart review of consecutive, nonneurogenic women who underwent VMSR for pain and reported persistent pain relief at the 6-month postoperative follow-up visit were assessed. Pre- and postoperative data collected were self-reported chief complaints, physical examination, other medical conditions associated with chronic pain, use of pain medications, Urogenital Distress Inventory-6 (in which question 6 specifically addresses pain), and the Numerical Pain Rating Scale (NPRS)...
July 10, 2017: International Urogynecology Journal
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