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https://www.readbyqxmd.com/read/29226044/neuroanatomy-and-neuropsychology-of-pain
#1
REVIEW
Shehzad Khalid, R Shane Tubbs
We have reviewed here the neuroanatomical and neuropsychological literature of the human brain and have proposed the various pain mechanisms that we currently know of. Essentially when tissue is damaged, peripheral nociceptors are activated continuously and prostanoids are hence produced. Nonsteroidal anti-inflammatory drugs (NSAIDs) and medications aim to target these prostanoids to treat the inflammatory component of pain. Normal pain tends to have a protective response. It is important for the nervous system to learn and recognize this painful stimulus earlier and quicker with repeated exposure to avoid tissue damage...
October 6, 2017: Curēus
https://www.readbyqxmd.com/read/29223594/femoral-neck-fractures-after-removal-of-hardware-in-healed-trochanteric-fractures
#2
REVIEW
Antonio Barquet, Peter V Giannoudis, Andrés Gelink
INTRODUCTION: Hardware removal in healed trochanteric fractures (TF) in the absence of infection or significant mechanical complications is rarely indicated. However, in patients with persistent pain, prominent material and discomfort in the activities of daily living, the implant is eventually removed. Publications of ipsilateral femoral neck fracture after removal of implants from healed trochanteric fractures (FNFARIHTF) just because of pain or discomfort are rare. The purpose of this systematic review of the literature is to report on the eventual risk factors, the mechanisms, the clinical presentation, and frequency, and to pay special emphasis in their prevention...
December 2017: Injury
https://www.readbyqxmd.com/read/29221479/in-screw-polymethylmethacrylate-augmented-sacroiliac-screw-for-the-treatment-of-fragility-fractures-of-the-pelvis-a-prospective-observational-study-with-1-year-follow-up
#3
Andreas Höch, Philipp Pieroh, Ralf Henkelmann, Christoph Josten, Jörg Böhme
BACKGROUND: The incidence of pelvic ring fractures in the elderly significantly increased. Because of persistent pain and immobilization associated with this injury, surgical treatment is recommended. To minimise comorbidities and surgical risk, percutaneous techniques are becoming more relevant. In-screw cement augmentation of sacroiliac screw fixation is a promising procedure; however, clinical follow-up data remain scarce. This study investigated the safety and possible complications of the procedure along with a 1-year follow-up...
December 8, 2017: BMC Surgery
https://www.readbyqxmd.com/read/29217672/digital-ischemia-after-application-of-self-adherent-elastic-wrap-dressing-a-case-series
#4
Christopher A Makarewich, Penelope Lang, Douglas T Hutchinson
Self-adherent elastic wrap dressings are a convenient option to manage pediatric hand and finger injuries. However, when improperly applied, they have the potential to cause devastating complications. We detail in this report 5 cases of dressing-induced ischemic injury to the hand in pediatric patients with a review of the literature. All patients were treated by the senior author between 2007 and 2015 and were retrospectively reviewed for initial injury, frequency of dressing changes, presence of pain, time to evaluation by the orthopedic hand team, treatment, and outcome...
December 7, 2017: Pediatrics
https://www.readbyqxmd.com/read/29210805/development-of-a-simple-preoperative-risk-score-for-persistent-pain-after-breast-cancer-surgery-a-prospective-observational-cohort-study
#5
Domitille Dereu, Georges L Savoldelli, Christophe Combescure, Stanislas Mathivon, Benno Rehberg
OBJECTIVES: Persistent postoperative pain concerns 30 to 50% of patients following breast cancer surgery. Studies testing preventive measures, however, have so far failed to produce consistent positive results. If preventive measures could be targeted to a subgroup of patients at high risk of persistent pain, positive results would be more likely. Our aim was to develop a simple risk score predicting persistent pain after breast cancer surgery. METHODS: In a prospective observational cohort study, we tested the predictive ability of a 4 simple items score for persistent pain in 200 patients scheduled for breast cancer surgery...
November 28, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29207908/a-scoping-review-of-pain-in-children-following-traumatic-brain-injury-is-there-more-than-headache
#6
Vivian Kwan, Mai Vo, Melanie Noel, Keith Owen Yeates
AIM: Headache is a common source of pain in children following traumatic brain injury (TBI); however, relatively little is known about non-headache pain in this pediatric population. The present review seeks to map the extant literature to determine the prevalence, characteristics, and impact of non-headache pain in children following TBI of all severities. RESULTS: Of 109 studies published on pain in children following a TBI, 95 (87%) were focused exclusively on headache pain and only 14 (13%) reported on non-headache pain or overall pain, with half (n = 7) in the form of case studies...
December 5, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29200678/radiofrequency-ablation-of-osteoid-osteoma-in-common-and-technically-challenging-locations-in-pediatric-population
#7
Shaileshkumar Garge, Shyamkumar Nidugala Keshava, Vinu Moses, George Koshy, Munawwar Ahmed, Suraj Mammen, Vrisha Madhuri
Context: Percutaneous radiofrequency ablation (RFA) of osteoid osteoma has a high technical and clinical success rate. However, there is limited data on its use in the pediatric population, especially in technically challenging locations. Objective: The objective of this study was to assess the safety and efficacy of CT-guided percutaneous RFA of osteoid osteoma in pediatric population. Subjects and Methods: From June 2009 to May 2014, thirty patients with osteoid osteoma were treated with CT-guided RFA in common (25 cases) and technically challenging (five cases: four near articular surface and one in sacrum) locations...
July 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29196860/role-of-thrombin-in-soluble-thrombomodulin-induced-suppression-of-peripheral-hmgb1-mediated-allodynia-in-mice
#8
Ryuichi Tsujita, Maho Tsubota, Yusuke Hayashi, Haruka Saeki, Fumiko Sekiguchi, Atsufumi Kawabata
High mobility group box 1 (HMGB1), a nuclear protein, once released into the extracellular space under pathological conditions, plays a pronociceptive role in redox-dependent distinct active forms, all-thiol HMGB1 (at-HMGB1) and disulfide HMGB1 (ds-HMGB1), that accelerate nociception through the receptor for advanced glycation endproducts (RAGE) and Toll-like receptor 4 (TLR4), respectively. Thrombomodulin (TM), an endothelial membrane protein, and soluble TM, known as TMα, promote thrombin-mediated activation of protein C and also sequester HMGB1, which might facilitate thrombin degradation of HMGB1...
December 1, 2017: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29192935/predictors-of-persistent-pain-after-fixation-of-distal-clavicle-fractures-in-an-active-military-population
#9
Paul J Lanier, Joshua Speirs, Logan Koehler, Julia Bader, Amr Abdelgawad, Brian R Waterman
Patients who undergo open reduction and internal fixation of distal clavicle fractures have a high rate of hardware removal and persistence of symptoms, particularly when attempting to return to high-demand activities. This study evaluated the outcomes of military servicemembers after surgical treatment of distal clavicle fractures. The authors performed a retrospective analysis of active duty servicemembers who underwent open reduction and internal fixation of Neer type II distal clavicle fractures between October 17, 2007, and July 20, 2012, with a minimum of 2-year clinical follow-up...
November 30, 2017: Orthopedics
https://www.readbyqxmd.com/read/29184436/continuous-wound-infusion-with-chloroprocaine-in-a-pig-model-of-surgical-lesion-drug-absorption-and-effects-on-inflammatory-response
#10
Massimo Allegri, Dario Bugada, Manuela De Gregori, Maria A Avanzini, Annalisa De Silvestri, Anna Petroni, Angelo Sala, Claudia Filisetti, Antonia Icaro Cornaglia, Lorenzo Cobianchi
Continuous wound infusion (CWI) may protect from inflammation, hyperalgesia and persistent pain. Current local anesthetics display suboptimal pharmacokinetic profile during CWI; chloroprocaine (CP) has ideal characteristics, but has never been tested for CWI. We performed an animal study to investigate the pharmacokinetic profile and anti-inflammatory effect of CP during CWI. A total of 14 piglets received an infusion catheter after pararectal laparotomy and were randomly allocated to one of three groups: 5 mL/h infusion of saline (group A), CP 1...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29180111/tactile-acuity-is-reduced-in-people-with-chronic-neck-pain
#11
Daniel S Harvie, Grace Edmond-Hank, Ashley D Smith
BACKGROUND: Tactile acuity deficits have been demonstrated in a range of persistent pain conditions and may reflect underlying cortical re-organisation. OBJECTIVE: This study aimed to determine whether tactile acuity is impaired in people with chronic neck pain relative to controls, and whether deficits relate to pain location, duration and intensity. METHODS: In this cross-sectional study, 20 people with chronic neck pain (5 idiopathic neck pain; 15 whiplash-associated disorder) and 20 pain-free controls underwent two-point discrimination (TPD) testing at the neck, back and arm, and point-to-point (PTP) and graphesthesia tests of tactile acuity at the neck and arm...
November 21, 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/29163341/effects-of-transcranial-direct-current-stimulation-transcranial-pulsed-current-stimulation-and-their-combination-on-brain-oscillations-in-patients-with-chronic-visceral-pain-a-pilot-crossover-randomized-controlled-study
#12
Aurore Thibaut, Cristina Russo, Aura Maria Hurtado-Puerto, Jorge Leon Morales-Quezada, Alícia Deitos, John Christopher Petrozza, Steven Freedman, Felipe Fregni
Objective: Chronic visceral pain (CVP) syndromes are persistently painful disorders with a remarkable lack of effective treatment options. This study aimed at evaluating the effects of different neuromodulation techniques in patients with CVP on cortical activity, through electreocephalography (EEG) and on pain perception, through clinical tests. Design: A pilot crossover randomized controlled study. Settings: Out-patient. Subjects: Adults with CVP (>3 months)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29146590/camkii%C3%AE-mediates-the-effect-of-il-17-to-promote-ongoing-spontaneous-and-evoked-pain-in-multiple-sclerosis
#13
Xiaoyu Hu, Fang Huang, Zaijie Jim Wang
Pain is a common and severe symptom in multiple sclerosis (MS), a chronic inflammatory and demyelinating disease of the central nervous system. The neurobiological mechanism underlying MS pain is poorly understood. In this study, we investigated the role of Ca(2+)/calmodulin dependent kinase type IIα (CaMKIIα) in driving chronic pain in MS using a mouse experimental autoimmune encephalomyelitis (EAE) model. We found that spinal CaMKIIα activity was enhanced in EAE correlating with the development of ongoing spontaneous pain and evoked hypersensitivity to mechanical and thermal stimuli...
November 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29145033/is-chronic-postsurgical-pain-surgery-induced-a-study-of-persistent-postoperative-pain-following-breast-reconstruction
#14
Randy S Roth, Ji Qi, Jennifer B Hamill, Hyungjin M Kim, Tiffany N S Ballard, Andrea L Pusic, Edwin G Wilkins
BACKGROUND: Chronic postsurgical pain (CPSP) is a reported risk for women undergoing breast reconstruction, but it remains unclear that such persistent pain is induced by reconstructive surgery. To address this concern, this prospective cohort study examined the prevalence of and risk factors associated with CPSP among women undergoing breast reconstruction. MATERIALS AND METHODS: Women (n = 1996) recruited for the Mastectomy Reconstruction Outcomes Consortium (MROC) Study were assessed preoperatively and at two-years postoperatively for relevant medical/...
November 13, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29139566/patient-reported-rates-of-chronic-pain-and-recurrence-after-groin-hernia-repair
#15
K-J Lundström, H Holmberg, A Montgomery, P Nordin
BACKGROUND: The effectiveness of different procedures in routine surgical practice for hernia repair with respect to chronic postoperative pain and reoperation rates is not clear. METHODS: This was prospective cohort study based on a unique combination of patient-reported outcomes and national registry data. Virtually all patients with a groin hernia repair in Sweden between September 2012 and April 2015 were sent a questionnaire 1 year after surgery. Persistent pain, defined as at least 'pain present, cannot be ignored, and interferes with concentration on everyday activities' in the past week was the primary outcome...
November 15, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29139193/higher-doses-of-intraoperative-analgesia-are-associated-with-lower-levels-of-persistent-pain-and-less-analgesic-consumption-six-months-after-total-hip-arthroplasty
#16
F von Dincklage, A Jakuscheit, J Weth, G Lichtner, C Jurth, B Rehberg-Klug
BACKGROUND: Persistent postoperative pain is a major health problem affecting nearly 30% of all patients undergoing total hip arthroplasty. Previous studies have demonstrated an association between the intensity of acute postoperative pain and persistent pain, but this association might be an epiphenomenon of insufficient intraoperative analgesia. In this study, we investigated the association between the intraoperative level of analgesia and the persistent postoperative pain 6 months after surgery...
November 14, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29135695/short-term-impact-of-assisted-deliveries-evaluation-based-on-behavioral-pain-scoring-and-heart-rate-variability
#17
Thameur Rakza, Laura Butruille, Ms Lucille Thirel, Veronique Houfflin-Debarge, Régis Logier, Laurent Storme, Julien DE Jonckheere
OBJECTIVES: Assisted deliveries are used in current practice by obstetrical teams during labor when the fetus is likely to face difficulties. In this study, we hypothesized that pain related to instrumental delivery could impair autonomic nervous system activity. METHODS: We investigated infants born by spontaneous delivery (SD group, n=35) and those whose deliveries were assisted by vacuum, forceps or both (AD group, n=35) between the 2 and 4 hours of life. Pain was evaluated using the EDIN behavioral pain scale (Neonatal Pain and Discomfort Scale)...
November 10, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29126847/visualization-of-painful-inflammation-in-patients-with-pain-after-traumatic-ankle-sprain-using-11-c-d-deprenyl-pet-ct
#18
Mikko Aarnio, Lieuwe Appel, Mats Fredrikson, Torsten Gordh, Olof Wolf, Jens Sörensen, Måns Thulin, Magnus Peterson, Clas Linnman
BACKGROUND AND AIMS: Positron emission tomography (PET) with the radioligand [(11)C]-D-deprenyl has shown increased signal at location of pain in patients with rheumatoid arthritis and chronic whiplash injury. The binding site of [(11)C]-D-deprenyl in peripheral tissues is suggested to be mitochondrial monoamine oxidase in cells engaged in post-traumatic inflammation and tissue repair processes. The association between [(11)C]-D-deprenyl uptake and the transition from acute to chronic pain remain unknown...
November 7, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29124418/the-effect-of-pre-transplant-pain-and-chronic-disease-self-efficacy-on-quality-of-life-domains-in-the-year-following-hematopoietic-stem-cell-transplantation
#19
Madeline L O'Sullivan, Rebecca A Shelby, Caroline S Dorfman, Sarah A Kelleher, Hannah M Fisher, Krista A Rowe Nichols, Francis J Keefe, Anthony D Sung, Tamara J Somers
PURPOSE: Pain is common for hematopoietic stem cell transplant (HSCT) patients and may be experienced pre-transplant, acutely post-transplant, and for months or years following transplant. HSCT patients with persistent pain may be at risk for poor quality of life following transplant; however, the impact of pre-transplant pain on quality of life post-transplant is not well understood. Self-efficacy for chronic disease management is associated with quality of life among cancer patients and may impact quality of life for HSCT patients...
November 9, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29122370/effectiveness-of-the-graded-motor-imagery-to-improve-hand-function-in-patients-with-distal-radius-fracture-a-randomized-controlled-trial
#20
Burcu Dilek, Cigdem Ayhan, Gozde Yagci, Yavuz Yakut
STUDY DESIGN: Single-blinded randomized controlled trial. INTRODUCTION: Pain management is essential in the early stages of the rehabilitation of distal radius fractures (DRFx). Pain intensity at the acute stage is considered important for determining the individual recovery process, given that higher pain intensity and persistent pain duration negatively affect the function and cortical activity of pain response. Graded motor imagery (GMI) and its components are recent pain management strategies, established on a neuroscience basis...
November 6, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
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