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https://www.readbyqxmd.com/read/29933273/spinal-activation-of-tropomyosin-receptor-kinase-b-recovers-the-impaired-endogenous-analgesia-in-neuropathic-pain-rats
#1
Daiki Kato, Takashi Suto, Hideaki Obata, Shigeru Saito
BACKGROUND: Although endogenous analgesia plays an important role in controlling pain states, chronic pain patients exhibit decreased endogenous analgesia compared to healthy individuals. In rats, noxious stimulus-induced analgesia (NSIA), which is an indicator of endogenous analgesia, diminished 6 weeks after spinal nerve ligation (SNL6W). A recent study in rats with deleted noradrenergic fibers demonstrated that the noradrenergic fibers were essential to NSIA. It has also been reported that brain-derived neurotrophic factor increased spinal noradrenergic fibers...
June 20, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29931581/the-involvement-of-free-fatty-acid-gpr40-ffar1-signaling-in-chronic-social-defeat-stress-induced-pain-prolongation-in-c57bl-6j-male-mice
#2
Fuka Aizawa, Kazuo Nakamoto, Shogo Tokuyama
RATIONALE: Depression and anxiety can cause the development of chronic pain. However, the mechanism of chronic pain induced by emotional dysfunction is still unknown. Previously, we demonstrated that the G protein-coupled receptor 40/free fatty acid receptor 1 (GPR40/FFAR1) signaling in the brain is related to regulation of both pain and emotion. In the present study, we proved that the role of GPR40/FFAR1 signaling in the development of chronic pain is induced by emotional dysfunction...
June 21, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29931400/abnormal-brain-white-matter-in-patients-with-right-trigeminal-neuralgia-a-diffusion-tensor-imaging-study
#3
Junpeng Liu, Jiajia Zhu, Fei Yuan, Xuejun Zhang, Quan Zhang
BACKGROUND: Idiopathic or classical trigeminal neuralgia (TN) is a chronic painful condition characterized by intermittent pain attacks. Enough evidence demonstrates classical TN is related to neurovascular compression (NVC) at the trigeminal root entry zone (REZ), but white matter change secondary to TN are not totally known. METHODS: Visual Analogue Scale (VAS) and diffusion tensor imaging were performed on 29 patients with right TN and 35 healthy individuals...
June 22, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29929839/management-of-headache-and-chronic-pain-in-pots
#4
REVIEW
Glen A Cook, Paola Sandroni
Primary headache syndromes and chronic pain syndromes are common in patients with postural tachycardia syndrome (POTS). There is overlap in potential mechanisms for migraine, chronic pain, and POTS symptomatology. Management of chronic pain and headaches in POTS requires a judicious use of pharmacotherapies that takes into account patient comorbidities and co-existing symptoms. Patient-centric, non-pharmacologic modalities include physical exercise, cognitive behavioral therapies, and treatment of sleep disorders...
June 12, 2018: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/29928864/definition-development-and-prevalence-of-new-persistent-opioid-use-following-hysterectomy
#5
Carolyn W Swenson, Neil S Kamdar, Kristian Seiler, Daniel M Morgan, Paul Lin, Sawsan As-Sanie
BACKGROUND: Opioids used for postoperative pain control after surgery have been associated with an increased risk of chronic opioid use. Hysterectomy is the most common major gynecologic procedure in the United States; however, we lack a data-driven definition of new persistent opioid use specific to hysterectomy. OBJECTIVE: 1) Determine a data-driven definition of new persistent opioid use among opioid naïve women undergoing hysterectomy; 2) Determine the prevalence of and risk factors for new persistent opioid use...
June 18, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29927949/snps-in-inflammatory-genes-ccl11-ccl4-and-mefv-in-a-fibromyalgia-family-study
#6
Zhifang Zhang, Jinong Feng, Allen Mao, Keith Le, Deirdre La Placa, Xiwei Wu, Jeffrey Longmate, Claudia Marek, R Paul St Amand, Susan L Neuhausen, John E Shively
BACKGROUND: Fibromyalgia (FM) is a chronic pain syndrome with a high incidence in females that may involve activation of the immune system. We performed exome sequencing on chemokine genes in a region of chromosome 17 identified in a genome-wide family association study. METHODS AND FINDINGS: Exome sequence analysis of 100 FM probands was performed at 17p13.3-q25 followed by functional analysis of SNPs found in the chemokine gene locus. Missense SNPs (413) in 17p13...
2018: PloS One
https://www.readbyqxmd.com/read/29927768/an-update-on-the-basic-and-clinical-science-of-ketamine-analgesia
#7
Lisa V Doan, Jing Wang
OBJECTIVE: In the context of the current opioid epidemic, there has been a renewed interest in the use of ketamine as an analgesic agent. METHODS: We have reviewed ketamine analgesia. RESULTS: Ketamine is well-known as an antagonist for N-methyl-D-aspartate receptors. In addition, it can regulate the function of opioid receptors and sodium channels. Ketamine also increases signaling through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors...
June 20, 2018: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29927422/-prognostic-models-of-the-severity-of-acute-dynamic-pain-on-the-first-postoperative-day-and-the-likelihood-of-chronic-postoperative-pain-in-spine-surgery
#8
P G Genov, V Kh Timerbaev, N S Dolgasheva, A A Efanov, A A Grin', O Yu Rebrova
The risk factors for acute pain as well as chronic pain syndrome (CPS) in spine surgery have not been defined to date. PURPOSE: To define the prognostic parameters of acute pain severity and the risk of CPS in patients operated on for spinal diseases and injuries. MATERIAL AND METHODS: The study included 291 patients operated on for degenerative diseases and injuries of the spine at the Sklifosovsky Research Institute of Emergency Medicine in 2010-2016. Sociodemographic and clinical data and the psychological status of patients were evaluated...
2018: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/29926144/lappaconitine-a-c18-diterpenoid-alkaloid-exhibits-antihypersensitivity-in-chronic-pain-through-stimulation-of-spinal-dynorphin-a-expression
#9
Ming-Li Sun, Jun-Ping Ao, Yi-Rui Wang, Qian Huang, Teng-Fei Li, Xin-Yan Li, Yong-Xiang Wang
Lappaconitine is a representative C18-diterpenoid alkaloid extracted from Aconitum sinomontanum Nakai and has been prescribed as a pain relief medicine in China for more than 30 years. This study evaluated its antihypersensitivity activity in the rat models of neuropathic and cancer pains and explored its underlying mechanisms. Subcutaneous injection of cumulative doses of lappaconitine produced dose-dependent mechanical antiallodynia and thermal antihyperalgesia in spinal nerve ligation-induced neuropathic rats...
June 20, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29925323/risk-of-opioid-misuse-in-chronic-non-cancer-pain-in-primary-care-patients-a-cross-sectional-study
#10
Johannes Maximilian Just, Linda Bingener, Markus Bleckwenn, Rieke Schnakenberg, Klaus Weckbecker
BACKGROUND: Efforts to improve treatment of pain using opioids have to adequately take into account their therapeutic shortcomings which involve addictiveness. While there are no signs of an "opioid epidemic" in Germany similar to that in the US, there is little data on the prevalence of prescription opioid misuse and addiction. Therefore, our objective was to screen primary care patients on long-term opioid therapy for signs of misuse of prescription opioids. METHODS: We recruited 15 GPs practices and asked all patients on long-term opioid therapy (> 6 months) to fill out a questionnaire including the "Current Opioid Misuse Measure" (COMM®), a self-report questionnaire...
June 20, 2018: BMC Family Practice
https://www.readbyqxmd.com/read/29924411/acceptance-psychiatric-symptoms-and-migraine-disability-an-observational-study-in-a-headache-center
#11
Elizabeth K Seng, Alexander J Kuka, Sarah Jo Mayson, Todd A Smitherman, Dawn C Buse
OBJECTIVE: To evaluate relationships between psychiatric symptoms, acceptance, and migraine-related disability in a sample of people with migraine presenting at a tertiary care headache center. BACKGROUND: Migraine is a chronic disease that can be severely disabling. Despite a strong theoretical basis and evidence in other pain conditions, little is known about relationships between acceptance, psychiatric symptoms, and migraine-related disability. METHODS: Ninety patients with physician-diagnosed migraine completed surveys assessing demographics, headache symptoms, severe migraine-related disability (Migraine Disability Assessment Scale total score dichotomized at ≥ 21), depression (Patient Health Questionnaire-9) and anxiety symptoms (Generalized Anxiety Disorder-7), and acceptance (Chronic Pain Acceptance Questionnaire; subscales: Pain Willingness and Activity Engagement)...
June 2018: Headache
https://www.readbyqxmd.com/read/29923953/ketamine-for-refractory-headache-a-retrospective-analysis
#12
Eric S Schwenk, Amir C Dayan, Ashwin Rangavajjula, Marc C Torjman, Mauricio G Hernandez, Clinton G Lauritsen, Stephen D Silberstein, William Young, Eugene R Viscusi
BACKGROUND AND OBJECTIVES: The burden of chronic headache disorders in the United States is substantial. Some patients are treatment refractory. Ketamine, an N-methyl-D-aspartate antagonist, provides potent analgesia in subanesthetic doses in chronic pain, and limited data suggest it may alleviate headache in some patients. METHODS: We performed a retrospective study of 61 patients admitted over 3 years for 5 days of intravenous therapy that included continuous ketamine to determine responder rate and patient and ketamine infusion characteristics...
June 19, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29923259/chronic-pain-in-narcolepsy-type-1-and-type-2-an-underestimated-reality
#13
Renata C Cremaschi, Camila Hirotsu, Sergio Tufik, Fernando M Coelho
Narcolepsy is a rare sleep disorder classified in types 1 and 2. The co-morbidities of narcolepsy type 1, with hypocretin-1 deficiency, are established. Hypocretin-1 in the central and peripheral nervous systems regulates nociception and pain. However, the patients with narcolepsy type 2 have similar excessive daytime sleepiness and co-morbidities without elucidation. The objective of the study was to determine the frequency and the characteristic of chronic pain according to the type of narcolepsy. We also investigated the effect of the interaction between the nutritional status and the type of narcolepsy...
June 19, 2018: Journal of Sleep Research
https://www.readbyqxmd.com/read/29922747/serum-response-factor-mediates-nociceptor-inflammatory-pain-plasticity
#14
Ruben Gomez, Dorothy M Kohler, Allison D Brackley, Michael A Henry, Nathaniel A Jeske
Introduction: Chronic metabotropic glutamate receptor activation in nociceptive afferents may upregulate A-Kinase Anchoring Protein 150 (AKAP150) expression and/or function. Objectives: To quantify transcriptional changes in AKAP150 expression and/or function after long-term mGluR5 agonist exposure, and identify transcriptional elements responsible. Methods: Dorsal root ganglia (DRG) were dissected from Sprague-Dawley rats and cultured for biochemical analysis of AKAP150 expression after prolonged mGluR5 agonist exposure...
May 2018: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29922746/reduced-intraepidermal-nerve-fibre-density-glial-activation-and-sensory-changes-in-hiv-type-1-tat-expressing-female-mice-involvement-of-tat-during-early-stages-of-hiv-associated-painful-sensory-neuropathy
#15
Rachel Wodarski, Deniz Bagdas, Jason J Paris, Tim Pheby, Wisam Toma, Ruqiang Xu, M Imad Damaj, Pamela E Knapp, Andrew S C Rice, Kurt F Hauser
Introduction: HIV infection is associated with chronic pain states, including sensory neuropathy, which affects greater than 40% of patients. Objectives and Methods: To determine the impact of HIV-Tat induction on nociceptive behaviour in female mice conditionally expressing HIV Tat1-86 protein through a doxycycline (DOX)-driven glial fibrillary acidic protein promoter, intraepidermal nerve fibre density and immune cell activation in the dorsal root ganglion (DRG) and spinal cord were assessed by immunohistochemistry...
May 2018: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29922745/first-in-human-randomized-clinical-trials-of-the-safety-and-efficacy-of-tanezumab-for-treatment-of-chronic-knee-osteoarthritis-pain-or-acute-bunionectomy-pain
#16
Patricia A Walicke, Franz Hefti, Roxanne Bales, Shiao-Ping Lu, Jon L Ruckle, Mark T Brown, Christine R West, David L Shelton
Introduction: The neurotrophin nerve growth factor has a demonstrated role in pain transduction and pathophysiology. Objectives: Two randomized, double-blind, placebo-controlled, phase 1 studies were conducted to evaluate safety, tolerability, and analgesic efficacy of single doses of tanezumab, a humanized anti-nerve growth factor monoclonal antibody, in chronic or acute pain. Methods: In the first study (CL001), patients with moderate to severe pain from osteoarthritis (OA) of the knee received a single intravenous infusion of tanezumab (3-1000 μg/kg) or placebo in a dose-escalation (part 1; N = 42) or parallel-arm (part 2; N = 79) study design...
May 2018: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29922744/anti-nerve-growth-factor-therapy-attenuates-cutaneous-hypersensitivity-and-musculoskeletal-discomfort-in-mice-with-osteoporosis
#17
Miyako Suzuki, Magali Millecamps, Seiji Ohtori, Chisato Mori, Laura S Stone
Introduction: The prevalence of osteoporosis is increasing with the aging population and is associated with increased risk of fracture and chronic pain. Osteoporosis is currently treated with bisphosphonate therapy to attenuate bone loss. We previously reported that improvement in bone mineral density is not sufficient to reduce osteoporosis-related pain in an ovariectomy (OVX)-induced mouse model of osteoporosis, highlighting the need for new treatments. Targeting of nerve growth factor (NGF) with sequestering antibodies is a promising new direction for the treatment of musculoskeletal pain including back pain and arthritis...
May 2018: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29922565/neuroma-implantation-into-long-bones-clinical-foundation-for-a-novel-osseointegrated-peripheral-nerve-interface
#18
Jacqueline S Israel, Aaron M Dingle, Ruston J Sanchez, Sahil K Kapur, Sarah Brodnick, Thomas J Richner, Jared P Ness, Joseph Novello, Justin C Williams, Samuel O Poore
Symptomatic neuroma after major extremity amputation is a challenging clinical problem for which there are many described treatment options. Neuroma excision and implantation into the medullary canal of long bones offers durability and insulation, and minimizes chronic pain. Another challenge in amputees is impaired function and an ongoing need for accessible and functional prostheses that are "bidirectional," in that they provide both fine motor control and sensory feedback. Drawing on clinical experience with neuroma implantation into the medullary canal of long bones, the authors propose a novel neural interface whereby a terminal nerve end is redirected into the medullary canal of a nearby long bone and interfaced with an electrode array...
May 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29922165/low-grk2-underlies-hyperalgesic-priming-by-glial-cell-derived-neurotrophic-factor
#19
Hui-Jing Wang, Han-Xin Gu, Niels Eijkelkamp, Cobi J Heijnen, Annemieke Kavelaars
Background: We recently identified the balance between the level of G protein coupled receptor kinase 2 (GRK2) and Epac1 in nociceptors as a key factor in the transition from acute to chronic pain that occurs in mice 'primed' by an inflammatory stimulus. Here, we examined the contribution of GRK2 and Epac-signaling to growth factor-induced hyperalgesic priming. Methods: Mice were primed by intraplantar injection with glial cell-derived neurotrophic factor (GDNF). Mechanical allodynia in response to PGE2 was followed over time in primed and non-primed animals...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29922084/bidirectional-association-between-disturbed-sleep-and-neuropathic-pain-symptoms-a-prospective-cohort-study-in-post-total-joint-replacement-participants
#20
Joanne Stocks, Nicole Ky Tang, David A Walsh, Sophie C Warner, Hollie L Harvey, Wendy Jenkins, Abhishek Abhishek, Michael Doherty, Ana M Valdes
Background: Disturbed sleep is strongly correlated with chronic pain. The aim of this study was to examine the association between sleep disturbance and incident joint pain focusing on neuropathic-like pain symptoms. Methods: A total of 423 individuals who had undergone total joint replacement (TJR) for osteoarthritis were assessed at the mean time of 3.6 years post-surgery and again at 5.9 years post-TJR, using the Medical Outcomes Survey sleep subscale, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and painDETECT questionnaire instruments...
2018: Journal of Pain Research
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