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https://www.readbyqxmd.com/read/29656511/neuropathic-pain-a-patient-centred-approach-to-measuring-outcomes
#1
Steve Hwang, Floortje van Nooten, Ted Wells, Aisling Ryan, Bruce Crawford, Christopher Evans, Marci English
BACKGROUND: Neuropathic pain (NP) is a complex, chronic pain state initiated by a primary lesion or dysfunction of the nervous system and presents as a variety of symptoms across multiple disease states. OBJECTIVE: To develop a patient-centred conceptual model of symptoms and impacts in subjects with diabetic peripheral neuropathy (DPN) or post-herpetic neuralgia (PHN) that can inform the measurement strategy in clinical trials. METHOD: Thirty subjects with DPN or PHN participated in in-person interviews which were performed until saturation was achieved...
April 15, 2018: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/29655685/polygonum-aviculare-l-extract-reduces-fatigue-by-inhibiting-neuroinflammation-in-restraint-stressed-mice
#2
Sun Haeng Park, Seol Jang, Eunjung Son, Si Woo Lee, Sun Dong Park, Yoon-Young Sung, Ho Kyoung Kim
BACKGROUND: Chronic fatigue patients experience various neuropsychological symptoms, including fatigue behaviors, chronic pain, and depression. They also display immune system dysregulation. Polygonum aviculare L. extract (PAE) is a traditional herbal medicine used to treat inflammatory diseases by reportedly decreasing pro-inflammatory cytokine production. HYPOTHESIS/PURPOSE: We hypothesized that the anti-inflammatory properties of PAE would attenuate fatigue symptoms in a mouse model of restraint stress...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29653266/proteome-based-systems-biology-in-chronic-pain
#3
David Gomez-Varela, Allison M Barry, Manuela Schmidt
Chronic pain represents a major medical challenge in the 21st century. Enormous efforts have been invested towards deciphering the complexity of chronic pain from different angles (molecular, physiological, psychosocial, and behavioral) in both preclinical and clinical settings. While progress has been made, our understanding of the underlying mechanisms of chronic pain remains insufficient. Consequently, chronic pain treatment is often inadequate. It lacks efficacy in most patients and is associated with detrimental side effects - a situation which calls for urgent changes in pain research and management...
April 10, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29652899/self-care-for-common-colds-a-european-multicenter-survey-on-the-role-of-subjective-discomfort-and-knowledge-about-the-self-limited-course-the-coco-study
#4
Anika Thielmann, Biljana Gerasimovska-Kitanovska, Tuomas H Koskela, Vildan Mevsim, Birgitta Weltermann
INTRODUCTION: Common colds are the most frequently encountered disease worldwide and the most frequent reason for self-care. According to the cross-sectional European Common Colds study (COCO), patients use as many as 12 items on average for self-care. Little is known about the influence of discomfort and knowledge on self-care for common colds. MAIN OBJECTIVE: To understand the influence of patients' discomfort during a cold and their knowledge about the self-limited disease course on the use of self-care measures...
2018: PloS One
https://www.readbyqxmd.com/read/29652682/kratom-an-emerging-drug-of-abuse-a-case-report-of-overdose-and-management-of-withdrawal
#5
Jack Diep, David Tian Chin, Somdatta Gupta, Faraz Syed, Ming Xiong, Jianguo Cheng
Kratom is an herb indigenous to Southeast Asia with psychoactive opioid compounds, often used as a treatment for chronic pain or opiate withdrawal symptoms. It is legally and readily available via Internet sales and has been identified as an emerging drug of abuse in the United States. Kratom use has been associated with psychosis, seizures, and even death. At lower doses, kratom acts as a stimulant, while at higher doses, it produces analgesia and euphoria. Here, we describe the successful management of kratom overdose and withdrawal in a young man with negative toxicology screens...
April 15, 2018: A&A practice
https://www.readbyqxmd.com/read/29652088/non-invasive-brain-stimulation-techniques-for-chronic-pain
#6
REVIEW
Neil E O'Connell, Louise Marston, Sally Spencer, Lorraine H DeSouza, Benedict M Wand
BACKGROUND: This is an updated version of the original Cochrane Review published in 2010, Issue 9, and last updated in 2014, Issue 4. Non-invasive brain stimulation techniques aim to induce an electrical stimulation of the brain in an attempt to reduce chronic pain by directly altering brain activity. They include repetitive transcranial magnetic stimulation (rTMS), cranial electrotherapy stimulation (CES), transcranial direct current stimulation (tDCS), transcranial random noise stimulation (tRNS) and reduced impedance non-invasive cortical electrostimulation (RINCE)...
April 13, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29649527/recommendations-for-evaluation-and-management-of-pain-in-patients-with-mucopolysaccharidosis-in-latin-america
#7
J M Politei, G Gordillo-González, N Guelbert, C F M Souza, C M Lourenço, M L Solano, M M Junqueira, T S P C Magalhães, A M Martins
The mucopolysaccharidosis (MPS) constitute a heterogeneous group of rare genetic disorders caused by enzymatic deficiencies that lead to the accumulation of glycosaminoglycans (GAGs). Several types of MPS are described, historically numbered from I to IX. Clinical observations strongly suggest the presence of chronic pain in patients with all types of MPS. There are few data in the literature on the evaluation and management of pain in these patients, a fact which can compromise the quality of life even more...
April 9, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29649262/antinociceptive-antibiotics-loaded-into-solid-lipid-nanoparticles-of-prolonged-release-measuring-pharmacological-efficiency-and-time-span-on-chronic-monoarthritis-rats
#8
Carlos Valdes, Gonzalo Bustos, Jose L Martinez, Claudio Laurido
Pain is a sensory experience of a complex physiological nature in which is not only involved the nervous system. Among its many features is the development of chronic pain that is more complicated to treat because of the central somatization processes involved, becoming inefficient treatments used in other forms of pain. Among them is the role of glial cells, whose participation is such that some authors have proposed to chronic pain as a gliopathy. Because of this, the drug target of possible treatments focuses on modulating nociceptive response affecting transduction into the central nervous system through affecting synapses in the dorsal horn of the spinal cord...
2018: PloS One
https://www.readbyqxmd.com/read/29649033/predictors-of-admission-after-the-implementation-of-an-enhanced-recovery-after-surgery-pathway-for-minimally-invasive-gynecologic-surgery
#9
Dayley S Keil, Lauren D Schiff, Erin T Carey, Janelle K Moulder, Amy M Goetzinger, Seema M Patidar, Lyla M Hance, Lavinia M Kolarczyk, Robert S Isaak, Paula D Strassle, Jay W Schoenherr
BACKGROUND: Enhanced recovery after surgery (ERAS) pathways in gynecologic surgery have been shown to decrease length of stay with no impact on readmission, but no study has assessed predictors of admission in this population. The purpose of this study was to identify predictors of admission after laparoscopic hysterectomy (LH) and robotic-assisted hysterectomy (RAH) performed under an ERAS pathway. METHODS: This is a prospective observational study of women undergoing LH/RAH for benign indications within an ERAS pathway...
April 11, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29649027/pain-and-its-long-term-interference-of-daily-life-after-critical-illness
#10
Christina J Hayhurst, Jim C Jackson, Kristin R Archer, Jennifer L Thompson, Rameela Chandrasekhar, Christopher G Hughes
BACKGROUND: Persistent pain likely interferes with quality of life in survivors of critical illness, but data are limited on its prevalence and risk factors. We sought to determine the prevalence of persistent pain after critical illness and its interference with daily life. Additionally, we sought to determine if intensive care unit (ICU) opioid exposure is a risk factor for its development. METHODS: In a cohort of adult medical and surgical ICU survivors, we used the brief pain inventory (BPI) to assess pain intensity and pain interference of daily life at 3 and 12 months after hospital discharge...
April 11, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29645354/the-price-of-pain-in-chronic-rhinosinusitis
#11
Kristine A Smith, Shaelene Ashby, Richard R Orlandi, Gretchen Oakley, Jeremiah A Alt
BACKGROUND: Chronic rhinosinusitis (CRS) is associated with productivity losses exceeding US$13 billion annually. Although pain is well known to significantly affect patient productivity in other diseases, its economic impact on CRS-related lost productivity has not been examined. The objective of this study was to determine whether CRS-related facial pain correlates with lost productivity in patients with CRS. METHODS: Seventy patients with CRS were enrolled in a cross-sectional investigation...
April 12, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29644656/pro-region-engineering-of-nerve-growth-factor-by-deep-mutational-scanning-enables-a-yeast-platform-for-conformational-epitope-mapping-of-anti-ngf-monoclonal-antibodies
#12
Angélica V Medina-Cucurella, Yaqi Zhu, Scott J Bowen, Lisa M Bergeron, Timothy A Whitehead
Nerve growth factor (NGF) plays a central role in multiple chronic pain conditions. As such, anti-NGF monoclonal antibodies (mAbs) that function by antagonizing NGF downstream signaling are leading drug candidates for non-opioid pain relief. To evaluate anti-canine NGF (cNGF) mAbs we sought a yeast surface display platform of cNGF. Both mature cNGF and pro-cNGF displayed on the yeast surface but bound conformationally sensitive mAbs at most 2.5-fold in mean fluorescence intensity above background, suggesting that cNGF was mostly misfolded...
April 12, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29644469/-cognitive-bias-research-and-depression-in-chronic-pain
#13
REVIEW
A C Rusu, J Hülsebusch
Chronic back pain is of enormous health and economic relevance for industrialized countries because a small group of patients with chronic disease is responsible for a large proportion of medical costs. The prevention of chronic disease is therefore a primary goal in the treatment of patients with acute low back pain. Psychological factors are the central risk factors for later chronification. Above all, especially depressive symptoms and occupational distress, as well as various maladaptive forms of pain management are central risk factors...
April 11, 2018: Der Schmerz
https://www.readbyqxmd.com/read/29644167/chronic-scrotal-pain-may-lead-to-reduced-sexual-function-and-interest-while-sexual-activity-may-worsen-chronic-scrotal-pain-double-jeopardy
#14
Aosama Aljumaily, Hind Abdul Jaleel Al-Khazraji, Allan Gordon, Susan Lau, Keith Allen Jarvi
Background: While it is recognized that chronic pain may adversely impact sexual function and activity in men and we also recognize that sexual activity may worsen the pain for men with chronic scrotal pain (CSP), the effect on sexual functioning and conversely the impact of sex on CSP has not previously been documented. Methods: Retrospective analysis of a prospectively collected database. Results: From Feb 2014 to Sep 2015, a total of 128 men presenting for assessment of CSP completed all or parts of a standardized questionnaire...
March 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29643902/is-there-difference-in-chronic-pain-after-suture-and-stapler-fixation-method-of-mesh-in-ventral-hernia-is-stapler-fixation-method-quicker-a-randomized-controlled-trial
#15
Noureen Shaukat, Farhat Jaleel, Masood Jawaid, Imrana Zulfiqar
Background & Objective: Chronic pain occurs in 20-30% of patients after hernia surgery. As a consequence of this chronic pain, almost one third of patients have limitations in daily activities. Frequency and severity of this pain varies with different techniques of hernia repair. The objective of this study was to compare polypropylene suture and skin staples for securing mesh in uncomplicated ventral hernioplasty in terms of acute and chronic postoperative pain and to compare the time taken for mesh fixation between polypropylene sutures and skin stapler in ventral hernioplasty...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29643634/tanezumab-therapy-targeting-nerve-growth-factor-in-pain-pathogenesis
#16
Mona K Patel, Alan D Kaye, Richard D Urman
In recent years, nerve growth factor (NGF) and the NGF receptor have become potential therapeutic targets in the treatment of acute and chronic pain states. NGF is a neurotrophin involved in regulating the function of sensory and sympathetic neurons during development. Numerous pain states have been linked to elevated levels of NGF and its role in increasing the perception of pain. Tanezumab, a recombinant humanized monoclonal antibody (IgG), was developed to target NGF, binding both circulating and local tissue NGF preventing interaction with the tropomyosin-related kinase-A and p75 receptors...
January 2018: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29643620/opioid-free-anesthesia-for-breast-cancer-surgery-an-observational-study
#17
Swagata Tripathy, Satyajit Rath, Suresh Agrawal, P Bhaskar Rao, A Panda, T S Mishra, Sukdev Nayak
Background and Aims: Opioids are associated with postoperative nausea, vomiting, drowsiness, and increased analgesic requirement. A nonopioid anesthesia technique may reduce morbidity, enable day care surgery, and possibly decrease tumor recurrence. We compared opioid-free, nerve block-based anesthesia with opioid-based general anesthesia for breast cancer surgery in a prospective cohort study. Material and Methods: Twenty four adult American Society of Anesthesiologists grade I-III patients posted for modified radical mastectomy (MRM) with axillary dissection were induced with propofol and maintained on isoflurane (0...
January 2018: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29643581/hypervigilance-to-pain-affects-activities-of-daily-living-an-examination-using-the-japanese-version-of-the-pain-vigilance-awareness-questionnaire
#18
Hayato Shigetoh
[Purpose] Hypervigilance to pain is an important aspect of the fear-avoidance model of pain that may be associated with disability more than other psychological factors examined. The aim of the study was to investigate how hypervigilance to pain influences disability compared with other psychological factors examined. [Subjects and Methods] The subjects of this study were 50 elderly patients with chronic pain (7 men and 43 women, 80.3 ± 7.8 years). To assess the pain level, the Numerical Rating Scale (NRS) was used...
December 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29628772/incidence-and-association-factors-for-the-development-of-chronic-post-hysterectomy-pain-at-4-and-6-month-follow-up-a-prospective-cohort-study
#19
Ban Leong Sng, Yin Ying Ching, Nian-Lin R Han, Farida Binte Ithnin, Rehena Sultana, Pryseley Nkouibert Assam, Alex Tiong Heng Sia
Chronic pain has major adverse effects on health-related quality of life and contributes to significant socioeconomic burden. Hysterectomy is a very common gynecological surgery, resulting in chronic post-hysterectomy pain (CPHP), an important pain syndrome. We conducted a prospective cohort study in 216 Asian women who underwent abdominal or laparoscopic hysterectomy for benign conditions. Demographic, psychological, and perioperative data were recorded. Postoperative 4- and 6-month phone surveys were conducted to assess the presence of CPHP and functional impairment...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29628598/transient-receptor-potential-channels-as-blood-biomarkers-for-pain-characteristics-in-patients-with-chronic-pain
#20
Norihiko Sukenaga, Munetaka Hirose
Transient receptor potential (TRP) channels play key roles for the transition from acute to chronic postoperative pain after surgery. To evaluate TRP channels in the peripheral blood cells as blood biomarkers for chronic pain, we collected blood samples for genome-wide assays of the mRNA expression and assessed pain intensity and the number of pain symptoms in 13 patients with chronic pain. There was a significant association between increases in the number of pain symptoms and increases in the TRP vanilloid 1 (TRPV1) expression...
January 2018: Anesthesia, Essays and Researches
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