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https://www.readbyqxmd.com/read/29470789/evaluation-of-psychometric-and-linguistic-properties-of-the-italian-adolescent-pain-assessment-scales-a-systematic-review
#1
REVIEW
Flavio Marti, Antonella Paladini, Giustino Varrassi, Roberto Latina
INTRODUCTION: Adolescents' pain experiences are complex and multidimensional, and evaluating pain only from a sensory and affective point of view may be in many instances limiting and inadequate; this is the reason why it is of paramount importance to identify the tools which can better assess the pain experienced by young patients. A person-oriented approach is highly encouraged, as it may better investigate the cognitive and behavioral development typical of this age group. The aim of this review paper is to describe the available tools which are able to adequately assess pain intensity in adolescents, in particular those validated in Italian...
February 22, 2018: Pain and Therapy
https://www.readbyqxmd.com/read/29470739/the-association-between-osteoarthritis-and-sleep-duration-in-koreans-a-nationwide-cross-sectional-observational-study
#2
Jae Hyun Jung, Hongdeok Seok, Sung Jae Choi, Junwoo Bae, Sang Hoon Lee, Moo Hwa Lee, Jae-Hoon Kim, Gwan Gyu Song
Osteoarthritis (OA) causes chronic pain, physical disability, and mental health deterioration and reduces the quality of life of patients. Sleep is an important factor in the recovery, and adequate sleep is important for quality of life. Several features of patients with OA can affect sleep time, and sleep also affects OA. We investigated the relationship between OA and sleep duration. Data for 2010-2012 were collected from the Korea National Health and Nutrition Examination Survey. We included 11,540 participants (4915 men and 6625 women)...
February 22, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29470472/ethnic-and-sex-related-differences-in-pain-characteristics-psychological-distress-and-pain-related-disability-in-patients-attending-a-new-zealand-teaching-hospital-pain-service
#3
Andrea Burri, David Rice, Nicola Kluger, Michal Kluger
AIM: The aim of the present observational study was to provide a description of the demographic, psychological and pain characteristics of patients attending the Waitemata Pain Services (WPS), Auckland, New Zealand. METHOD: Data were collected via a comprehensive paper-pencil questionnaire handed out to 798 consecutive new patients seen at the WPS over a four-year period. RESULTS: 32.3% attending the WPS were men and 67.7% women, with a mean age of 52...
February 23, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29470418/tetrodotoxin-a-candidate-drug-for-nav1-1-induced-mechanical-pain
#4
César Mattei
Tetrodotoxin (TTX), the mode of action of which has been known since the 1960s, is widely used in pharmacology as a specific inhibitor of voltage-gated sodium channels (Nav channels). This toxin has contributed to the characterization of the allosteric model of the Nav channel, and to discriminating TTX-sensitive and TTX-resistant subtypes. In addition to its role as a pharmacological tool, TTX is now considered a therapeutic molecule, and its development should lead to its use in certain pathologies involving Nav channels, particularly in the field of pain...
February 22, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29470314/genetic-variation-in-p2rx7-and-pain-tolerance
#5
O Kambur, M A Kaunisto, B S Winsvold, T Wilsgaard, A Stubhaug, J A Zwart, E Kalso, C S Nielsen
P2X7 is a non-selective cation channel activated by extracellular ATP. P2X7 activation contributes to the pro-inflammatory response to injury or bacterial invasion and mediates apoptosis. Recently, P2X7 function has been linked to chronic inflammatory and neuropathic pain. P2X7 may contribute to pain modulation both by effects on peripheral tissue injury underlying clinical pain states, and through alterations in central nervous system processing, as suggested by animal models. To further test its role in pain sensitivity, we examined whether variation within the P2RX7 gene, which encodes the P2X7 receptor, was associated with experimentally induced pain in human patients...
February 20, 2018: Pain
https://www.readbyqxmd.com/read/29470313/injustice-perceptions-about-pain-parent-child-discordance-is-associated-with-worse-functional-outcomes
#6
Megan M Miller, David Wuest, Amy E Williams, Eric L Scott, Zina Trost, Adam T Hirsh
Pain is experienced in and influenced by social environments. For children with chronic pain, the child-parent relationship and parental beliefs about pain are particularly important and may influence pain outcomes. Pain-related injustice perceptions have recently been identified as an important cognitive-emotional factor for children with pain. The current study aimed to better understand the pain-related injustice perceptions of children with chronic pain and their parents. The sample consisted of 253 pediatric chronic pain patients (mean age=14...
February 20, 2018: Pain
https://www.readbyqxmd.com/read/29469908/limited-jaw-movements-and-somatization-but-not-pain-may-play-a-role-in-salivary-flow-in-female-patients-with-temporomandibular-disorders
#7
Irena Mladenovic, Jelena Krunic, Nikola Stojanovic, Dusanka Markovic, Silvia Rdt de Siqueira
AIMS: To explore the unstimulated salivary flow rate and subjective feeling of oral dryness in young adult women with temporomandibular disorders (TMD) and their relation to the presence of chronic pain, depression, somatization, and limited mandibular mobility. METHODS: Unstimulated whole saliva flow rate and presence of oral dryness were determined in 45 women with TMD and 30 healthy controls. The Research Diagnostic Criteria for TMD (RDC/TMD) were used for assessment of TMD, chronic pain, depression, somatization, and mandibular mobility...
February 21, 2018: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29468979/potentiation-of-warfarin-associated-with-salsalate-therapy-resulting-in-bleeding
#8
Joseph P Rindone, Chadwick K Mellen
BACKGROUND: Salsalate may offer many advantages over other non-steroidal anti-inflammatory agents in patients taking warfarin, however a drug-drug interaction may occur which has not been reported in the medical literature or by the manufacturer of salsalate. OBJECTIVE: To report a case of warfarin potentiation associated with salsalate treatment, which resulted in bleeding. METHODS: Clinical review of the course of a patient, who was stable on warfarin when salsalate therapy was added for chronic pain...
February 19, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29468928/the-work-of-childhood-understanding-school-functioning-in-youth-with-chronic-pain
#9
Kailyn Jones, David Nordstokke, Gabrielle Wilcox, Meadow Schroeder, Melanie Noel
School is often cited as the 'work of childhood' and serves as an important site for child and adolescent development. Frequent school absences in children and adolescents with chronic pain are well documented; however, variables that may explain school impairment are not understood. The potential consequences of school impairment are extensive, as these children and adolescents are at great risk for achieving poor grades and sometimes require full-time homebound instruction. This, in turn, can have adverse effects on occupational and social functioning well into adulthood...
February 22, 2018: Pain Management
https://www.readbyqxmd.com/read/29468702/identifying-optimal-dosage-regimes-under-safety-constraints-an-application-to-long-term-opioid-treatment-of-chronic-pain
#10
Eric B Laber, Fan Wu, Catherine Munera, Ilya Lipkovich, Salvatore Colucci, Steve Ripa
There is growing interest and investment in precision medicine as a means to provide the best possible health care. A treatment regime formalizes precision medicine as a sequence of decision rules, one per clinical intervention period, that specify if, when and how current treatment should be adjusted in response to a patient's evolving health status. It is standard to define a regime as optimal if, when applied to a population of interest, it maximizes the mean of some desirable clinical outcome, such as efficacy...
February 21, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/29468673/chronic-pain-prevalence-and-associated-factors-in-adolescents-with-and-without-physical-disabilities
#11
Rocío de la Vega, Cornelius Groenewald, Maggie H Bromberg, Sarah E Beals-Erickson, Tonya M Palermo
AIM: Adolescents with physical disabilities may have co-occurring chronic pain, but the prevalence and specific associated factors are unknown. The aims of this study were to determine (1) the prevalence of chronic pain in adolescents with physical disabilities and (2) whether known correlates of chronic pain in the general population are also present in young people both with physical disability and with chronic pain relative to peers. METHOD: We conducted a secondary analysis of cross-sectional nationally representative data from the National Longitudinal Study of Adolescent to Adult Health...
February 22, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29468561/chronic-pain-in-medullary-sponge-kidney-a-rare-and-never-described-clinical-presentation
#12
G Gambaro, D S Goldfarb, R Baccaro, J Hirsch, N Topilow, S D'Alonzo, G Gambassi, P M Ferraro
Medullary sponge kidney (MSK) is a cause of nephrocalcinosis, associated with hematuria, renal colic, pyelonephritis. There are rare and atypical MSK cases characterized by chronic severe pain (CP), whose features are unknown, in particular the relationship with the stone disease activity. This study analyzes a cohort of MSK-CP patients belonging to three North-America self-support Facebook groups. Patients had to self-administer an on-line questionnaire (on intensity, progression and MSK-associated conditions, stone-related disease, pain features, drug use), the Brief Pain Inventory, the Fatigue Severity Score, and Wisconsin Quality of Life (WQL) in stone formers questionnaires...
February 21, 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/29468510/-help-for-self-help-for-patients-with-chronic-pain
#13
REVIEW
Andreas Böger, Chr Braun, M Butz
No abstract text is available yet for this article.
September 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/29467019/clinical-and-cost-effectiveness-of-the-star-care-pathway-compared-to-usual-care-for-patients-with-chronic-pain-after-total-knee-replacement-study-protocol-for-a-uk-randomised-controlled-trial
#14
Vikki Wylde, Wendy Bertram, Andrew D Beswick, Ashley W Blom, Julie Bruce, Amanda Burston, Jane Dennis, Kirsty Garfield, Nicholas Howells, Athene Lane, Candy McCabe, Andrew J Moore, Sian Noble, Tim J Peters, Andrew Price, Emily Sanderson, Andrew D Toms, David A Walsh, Simon White, Rachael Gooberman-Hill
BACKGROUND: Approximately 20% of patients experience chronic pain after total knee replacement. There is little evidence for effective interventions for the management of this pain, and current healthcare provision is patchy and inconsistent. Given the complexity of this condition, multimodal and individualised interventions matched to pain characteristics are needed. We have undertaken a comprehensive programme of work to develop a care pathway for patients with chronic pain after total knee replacement...
February 21, 2018: Trials
https://www.readbyqxmd.com/read/29466721/insights-from-molecular-dynamics-simulations-to-exploit-new-trends-for-the-development-of-improved-opioid-drugs
#15
REVIEW
Marta Filizola
Having accidental deaths from opioid overdoses almost quadrupled over the past fifteen years, there is a strong need to develop new, non-addictive medications for chronic pain to stop one of the deadliest epidemics in American history. Given their potentially fewer on-target overdosing risks and other adverse effects compared to classical opioid drugs, attention has recently shifted to opioid allosteric modulators and G protein-biased opioid agonists as likely drug candidates to prevent and/or reverse opioid overdoses...
February 18, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29466525/-chronic-diseases-in-the-population-affected-by-the-armed-conflict-in-colombia-2015
#16
Carlos Gómez-Restrepo, Carlos Javier Rincón, Mauricio Medina-Rico
OBJECTIVE: The purpose of this study was to identify the most frequent non-mental chronic illnesses in the Colombian population affected by the armed conflict. METHODOLOGY: A cross-sectional study using data from the National Mental Health Survey 2015. The study population was stratified by sex and age and other general data were extracted, including education and poverty level, measured by the Multidimensional Poverty Index. Data analysis was based on information from people who reported having been victims of the Colombian armed conflict at some time in their lives; the frequency of presentation of non-mental chronic illnesses was reported as a measure of indirect relative risk...
February 19, 2018: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/29465625/spinal-bromodomain-containing-protein-4-contributes-to-neuropathic-pain-induced-by-hiv-glycoprotein-120-with-morphine-in-rats
#17
Keiya Takahashi, Hyun Yi, Ching-Hang Liu, Shue Liu, Yuta Kashiwagi, Dennis J Patin, Shuanglin Hao
The symptoms of HIV-sensory neuropathy are dominated by neuropathic pain. Recent data show that repeated use of opiates enhances the chronic pain states in HIV patients. Limited attention has so far been devoted to exploring the exact pathogenesis of HIV painful disorder and opiate abuse in vivo, for which there is no effective treatment. Bromodomain-containing protein 4 (Brd4) is a member of the bromodomain and extraterminal domain protein (BET) family and functions as a chromatin 'reader' that binds acetylated lysines in histones in brain neurons to mediate the transcriptional regulation underlying learning and memory...
February 20, 2018: Neuroreport
https://www.readbyqxmd.com/read/29465470/opioid-addiction-diversion-and-abuse-in-chronic-and-cancer-pain
#18
Vijay Kata, Matthew B Novitch, Mark R Jones, Best O Anyama, Erik M Helander, Alan D Kaye
PURPOSE OF REVIEW: The primary cause of overdose death in the United States is related to pharmaceutical opioids. A few particular populations that struggle with adverse outcomes related to opioid abuse are those in palliative care, those with chronic pain, and those receiving pain treatments secondary to cancer or chemotherapy. RECENT FINDINGS: There have been massive efforts to decrease the use of opioid abuse in patient care in a gestalt manner, but palliative care provides unique challenges in applying these reduction tactics used by other specialties...
February 19, 2018: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/29464783/synthetic-mid-urethral-sling-complications-evolution-of-presenting-symptoms-over-time
#19
Connie Wang, Alana L Christie, Philippe E Zimmern
INTRODUCTION: To study the evolution of type of presenting symptoms after mid-urethral sling (MUS) placement relative to the interval between placement and subsequent synthetic sling removal (SSR) for complication(s). METHODS: An IRB-approved, prospectively maintained database of women who underwent SSR was retrospectively reviewed for demographics, interval between MUS placement and SSR, history of chronic pain syndromes and recurrent urinary tract infections (RUTI), anti-incontinence and prolapse repairs, and MUS-related symptoms at presentation, including storage dysfunction, voiding dysfunction, RUTI, vaginal pain, non-vaginal pain, mesh exposure, and urinary incontinence (UI)...
February 21, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29464382/repair-of-the-severe-muscle-aponeurotic-abdominal-laxity-with-alloplastic-mesh-in-aesthetic-abdominoplasty
#20
Alberto M L Caldeira, Kelly Carrión, John Jaulis
BACKGROUND: Abdominoplasty is the most frequently performed surgical procedure for body contour; in our experience, we have observed some patients with prominent bulging that is difficult to treat and that presents results that are unsatisfactory or have recurrences to conventional treatments. This leads us to carry out an analysis of the elements responsible for the containment and abdominal format. We determined that it may be due to an inability of an important sagging aponeurotic muscle of primary origin to support the abdomen and could be caused by predisposing factors...
February 20, 2018: Aesthetic Plastic Surgery
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