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https://www.readbyqxmd.com/read/29231159/facet-joint-injections-for-non-specific-low-back-pain-a-feasibility-rct
#1
Saowarat Snidvongs, Rod S Taylor, Alia Ahmad, Simon Thomson, Manohar Sharma, Angela Farr, Deborah Fitzsimmons, Stephanie Poulton, Vivek Mehta, Richard Langford
BACKGROUND: Pain of lumbar facet-joint origin is a common cause of low back pain in adults and may lead to chronic pain and disability, with associated health and socioeconomic implications. The socioeconomic burden includes an inability to return to work resulting in loss of productivity in addition to direct and indirect health-care utilisation costs. Lumbar facet-joints are paired synovial joints between the superior and inferior articular processes of consecutive lumbar vertebrae and between the fifth lumbar vertebra and the sacrum...
December 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29230551/-pain-and-poverty
#2
REVIEW
D Feierabend, J Walter, R Kalff, R Reichart
BACKGROUND: Poverty is an important problem in Germany. The health effects of poverty can lead to a higher risk of disease and the arising of chronic affections. On the other hand chronic illness may support the development and continuance of poverty. The context of chronic pain and poverty has not been analyzed so far. OBJECTIVES: We investigated the correlation between chronic pain and poverty. MATERIALS AND METHODS: In a prospective manner we interviewed 20 patients with pain syndromes during our consultation hour regarding their household income...
December 11, 2017: Der Schmerz
https://www.readbyqxmd.com/read/29229431/altered-neurocognitive-processing-of-tactile-stimuli-in-patients-with-complex-regional-pain-syndrome-crps
#3
Anoop Kuttikat, Valdas Noreika, Srivas Chennu, Nicholas Shenker, Tristan Bekinschtein, Christopher A Brown
Chronic pain in CRPS has been linked to tactile misperceptions and deficits in somatotopic representation of the affected limb. Here, we identify altered cognitive processing of tactile stimuli in CRPS patients that we propose marks heterogeneity in tactile decision-making mechanisms. In a case-control design, we compared middle and late-latency somatosensory-evoked potentials (SEPs) in response to pseudo-randomised mechanical stimulation of the digits of both hands (including CRPS-affected and non-affected sides) between 13 CRPS patients and 13 matched healthy controls...
December 8, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29229430/self-guided-online-cognitive-behavioral-strategies-for-chemotherapy-induced-peripheral-neuropathy-a-multicenter-pilot-randomized-wait-list-controlled-trial
#4
Robert Knoerl, Ellen M L Smith, Debra L Barton, David A Williams, Janean E Holden, John C Krauss, Beth LaVasseur
The purpose of this pilot, parallel, randomized-controlled trial was to examine the efficacy of a self-guided online cognitive and behaviorally-based pain management intervention (PROSPECT) to reduce "worst" pain for individuals with chronic painful chemotherapy-induced peripheral neuropathy (CIPN). Secondary outcomes included "average" pain, non-painful CIPN symptom severity, impression of change, and pain interference. Sixty patients with chronic painful CIPN were recruited from five outpatient academic and community cancer centers...
December 8, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29229212/acid-induced-experimental-muscle-pain-and-hyperalgesia-with-single-and-repeated-infusion-in-human-forearm
#5
Kelun Wang, Yi Luo, Toshiyuki Asaki, Thomas Graven-Nielsen, Brian E Cairns, Thomas Arendt-Nielsen, Lars Arendt-Nielsen
BACKGROUND AND PURPOSE: Acid has long been thought to play an important role in the pain process. Animal study showed that repeated acid stimulation induced central sensitization. The purpose of the study is to investigate muscle pain and hyperalgesia evoked by intramuscular infusion of saline at different pH levels, and to compare the effect of a single versus repeated acid infusions. METHODS: Twenty healthy subjects received infusions of buffered saline (pH 5...
October 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29229210/prevalence-and-characteristics-of-chronic-pain-experience-of-niger
#6
Hamid Assadeck, Moussa Toudou Daouda, Fatimata Hassane Djibo, Djibo Douma Maiga, Eric Adehossi Omar
INTRODUCTION: Chronic pain is a major health problem, considered as a disease in its own right. The prevalence of chronic pain is estimated to be between 2% and 40% in adult populations. In Niger, there are no data on chronic pain. AIMS: This study was designed to provide the demographic, clinical and etiological profile of chronic pain in patients from Niger in order to create a database on chronic pain in Niger. PATIENTS AND METHODS: Our study is prospectively conducted at the department of external consultation of the Hôpital National de Niamey over a period of 10 months from 31 May 2016 to 30 January 2017 collecting all cases of chronic pain...
October 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29229208/assessment-and-treatment-at-a-pain-clinic-a-one-year-follow-up-of-patients-with-chronic-pain
#7
Andrea Hållstam, Monika Löfgren, Lina Benson, Christer Svensén, Britt-Marie Stålnacke
BACKGROUND AND AIMS: Pain is one of the most common reasons for patients to seek primary health care. Pain relief is likely to be achieved for patients suffering from acute pain, but for individuals with chronic pain it is more likely that the condition will persist. These patients have the option of being referred to specialised pain clinics. However, the complexity surrounding chronic pain patients is not well studied in these settings. This study aimed to describe patients with chronic pain referred to a pain clinic by using the information submitted during their first visit and one year later and also to identify associations between baseline characteristics and improvements in health-related quality of life in the follow-up...
October 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29227505/neurobiology-of-sexual-assault-and-osteopathic-considerations-for-trauma-informed-care-and-practice
#8
Kristen M Cuevas, Jane Balbo, Krista Duval, Elizabeth A Beverly
Sexual assault is a traumatic event with potentially devastating lifelong effects on physical and emotional health. Sexual assault is associated with gastrointestinal, neurologic, and reproductive symptoms, as well as obesity, diabetes, and chronic pain. With 1 in 3 women and 1 in 6 men experiencing some form of unwanted sexual violence in their lifetime, sexual assault is a significant public health problem that necessitates attention in the medical community. This review discusses relevant literature on the neurobiologic changes that occur as a consequence of sexual assault, such as how the brain responds during a traumatic experience and the impact of trauma on memory...
December 11, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/29227460/neuropathic-like-ocular-pain-and-nonocular-comorbidities-correlate-with-dry-eye-symptoms
#9
Victoria S Chang, Terri P Rose, Carol L Karp, Roy C Levitt, Constantine Sarantopoulos, Anat Galor
OBJECTIVE: To evaluate the association between dry eye (DE) symptoms and neuropathic-like ocular pain (NOP) features, chronic pain conditions, depression, and anxiety in patients presenting for routine ophthalmic examinations. METHODS: Two hundred thirty-three consecutive patients ≥18 years of age presenting to a comprehensive eye clinic between January and August 2016 were included in this study. Information on demographics, chronic pain conditions, medication use, DE symptoms (dry eye questionnaire, DEQ5), NOP complaints (burning; wind, light, and temperature sensitivity), depression, and anxiety indices (patient health questionnaire 9, PHQ-9 and symptom checklist 90-revised, SCL-90-R) were collected for each individual...
December 7, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/29224989/synovial-calprotectin-an-inexpensive-biomarker-to-exclude-a-chronic-prosthetic-joint-infection
#10
Marjan Wouthuyzen-Bakker, Joris J W Ploegmakers, Karsten Ottink, Greetje A Kampinga, Lucie Wagenmakers-Huizenga, Paul C Jutte, Anneke C M Kobold
BACKGROUND: To diagnose or exclude a chronic prosthetic joint infection (PJI) can be a clinical challenge. Therefore, sensitive and specific biomarkers are needed in the diagnostic work-up. Calprotectin is a protein with antimicrobial properties and is released by activated neutrophils, making it a specific marker for infection. Because of its low costs and ability to obtain a quantitative value as a point of care test, it is an attractive marker to use in clinical practice. In addition, the test is already used in routine care in most hospitals for other indications and therefore easy to implement...
November 13, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29224919/assessment-of-tapentadol-api-abuse-liability-with-the-researched-abuse-diversion-and-addiction-related-surveillance-radars-system
#11
Suzanne K Vosburg, S Geoffrey Severtson, Richard C Dart, Theodore J Cicero, Steven P Kurtz, Mark W Parrino, Jody L Green
Tapentadol, a Schedule II opioid with a combination of µ-opioid activity and norepinephrine reuptake inhibition, is used for the management of moderate to severe acute and chronic pain. Its dual-mechanism of action is thought to reduce opioid-related side effects that can complicate pain management. Since approval, tapentadol has been tracked across multiple outcomes suggesting abuse liability, and a pattern of relatively low, although not absent, abuse liability has been found. This retrospective cohort study further details the abuse liability of tapentadol as an Active Pharmaceutical Ingredient (API) when both immediate-release and extended-release formulations were on the market together (4Q2011 to 2Q2016)...
December 7, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29224410/reduction-of-opioid-use-and-improvement-in-chronic-pain-in-opioid-experienced-patients-after-topical-analgesic-treatment-an-exploratory-analysis
#12
Jeffrey A Gudin, Michael J Brennan, E Dennis Harris, Peter L Hurwitz, Derek T Dietze, James D Strader
OBJECTIVE: There is a need to identify safe and effective opioid-sparing multimodal alternative treatment strategies and approaches, including topical analgesics, for opioid-experienced chronic pain patients to mitigate the risk of addiction, misuse, and abuse of opioids. METHODS: This subset analysis from a prospective, observational study evaluated changes in opioid use, other concurrent medication use, and pain severity and interference in opioid-experienced patients (OEP) treated with topical analgesics for chronic pain with measures obtained at baseline and 3- and 6- month follow-up...
December 11, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/29224222/chronic-pain-in-the-school-setting-the-teachers-point-of-view
#13
Ester Solé, Elena Castarlenas, Elisabet Sánchez-Rodríguez, Santiago Galán, Rocío de la Vega, Mark P Jensen, Jordi Miró
BACKGROUND: The aims of this study were to (1) examine the reactions of teachers and student teachers to children experiencing pain, (2) identify the most common challenges and potential resources that are associated to dealing with them, and (3) examine whether their responses differed as a function of their experience or sex. METHODS: Forty teachers and 318 student teachers completed a survey which included descriptive information, a questionnaire that assesses different responses of participants to children who experience pain, and provides a list of problems and resources that participants might encounter and implement, respectively, when dealing with these children...
January 2018: Journal of School Health
https://www.readbyqxmd.com/read/29224058/systematic-assessment-and-characterization-of-chronic-pain-in-multiple-sclerosis-patients
#14
Diana Ferraro, Domenico Plantone, Franca Morselli, Giulia Dallari, Anna M Simone, Francesca Vitetta, Patrizia Sola, Guido Primiano, Viviana Nociti, Matteo Pardini, Massimiliano Mirabella, Catello Vollono
Pain is one of the most disabling clinical symptoms in patients with multiple sclerosis (MS). Several studies have already assessed the prevalence of pain in MS patients, reporting variable results, probably due to methodological differences. The aim of this single-centre cross-sectional study was to define the prevalence and characteristics of chronic pain in a population of MS patients using validated tools, and to analyse these data in relation to demographic and clinical features, including disease duration and disability (EDSS and its single functional system scores)...
December 9, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29223784/thalidomide-attenuates-development-of-morphine-dependence-in-mice-by-inhibiting-pi3k-akt-and-nitric-oxide-signaling-pathways
#15
Muhammad Imran Khan, Majid Momeny, Sattar Ostadhadi, Samane Jahanabadi, Shahram Ejtemaee-Mehr, Bilqees Sameem, Ghazaleh Zarrinrad, Ahmad Reza Dehpour
Morphine dependence and the subsequent withdrawal syndrome restrict its clinical use in management of chronic pain. The precise mechanism for the development of dependence is still elusive. Thalidomide is a glutamic acid derivative, recently has been reconsidered for its clinical use due to elucidation of different clinical effects. Phosphoinositide 3-kinase (PI3K) is an intracellular transducer enzyme which activates Akt which in turns increases the level of nitric oxide. It is well established that elevated levels of nitric oxide has a pivotal role in the development of morphine dependence...
December 6, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29222926/depressive-personality-vulnerability-in-chronic-physical-pain-centrality-of-sociotropy
#16
Golan Shahar, Sheera F Lerman, Maayan Topaz, Silviu Brill, Hadar Shalev, Zvia Rudich
BACKGROUND: Chronic physical pain is one of modern medicine's principal challenges. Recently, there has been a keen research interest in the role of Depressive Personality Vulnerability (DPV) in the course of chronic pain. OBJECTIVE: This is the first attempt to examine the role of three leading DPV dimensions - sociotropy, autonomy, and self-criticism - in chronic pain. METHOD: Chronic pain patients (N = 428) were assessed four times as to their pain, disability, anxious-depression, and pain-based catastrophizing...
December 9, 2017: Journal of Personality
https://www.readbyqxmd.com/read/29222304/targeting-novel-mechanisms-of-pain-in-sickle-cell-disease
#17
REVIEW
Huy Tran, Mihir Gupta, Kalpna Gupta
Patients with sickle cell disease (SCD) suffer from intense pain that can start during infancy and increase in severity throughout life, leading to hospitalization and poor quality of life. A unique feature of SCD is vaso-occlusive crises (VOCs) characterized by episodic, recurrent, and unpredictable episodes of acute pain. Microvascular obstruction during a VOC leads to impaired oxygen supply to the periphery and ischemia reperfusion injury, inflammation, oxidative stress, and endothelial dysfunction, all of which may perpetuate a noxious microenvironment leading to pain...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29222302/pain-measurement-tools-in-sickle-cell-disease-where-are-we-now
#18
REVIEW
Deepika S Darbari, Amanda M Brandow
Pain is a complex multidimensional experience and the most common morbidity in patients with sickle cell disease (SCD). Tools to assess pain can be of use not only to guide pain treatment but also to provide insight into underlying pain neurobiology. Mechanisms of pain in SCD are multifactorial and are not completely elucidated. Although vaso-occlusion of microcirculation by sickled red cells is believed to be the underlying mechanism of acute vaso-occlusive pain, mechanisms for chronic pain and the transition from acute to chronic pain are under investigation...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29222301/optimizing-the-care-model-for-an-uncomplicated-acute-pain-episode-in-sickle-cell-disease
#19
REVIEW
Paul Telfer, Banu Kaya
The pathophysiology, clinical presentation, and natural history of acute pain in sickle cell disease are unique and require a disease-centered approach that also applies general principles of acute and chronic pain management. The majority of acute pain episodes are managed at home without the need to access health care. The long-term consequences of poorly treated acute pain include chronic pain, adverse effects of chronic opioid usage, psychological maladjustment, poor quality of life, and excessive health care utilization...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29222285/five-lessons-learned-about-long-term-pain-management-in-adults-with-sickle-cell-disease
#20
REVIEW
Joshua J Field
Chronic pain affects one-half of adults with sickle cell disease (SCD). Despite the prevalence of chronic pain, few studies have been performed to determine the best practices for this patient population. Although the pathophysiology of chronic pain in SCD may be different from other chronic pain syndromes, many of the guidelines outlined in the pain literature and elsewhere are applicable; some were consensus-adopted in the 2014 National Heart, Lung, and Blood Institute SCD Guidelines. Recommended practices, such as controlled substance agreements and monitoring of urine, may seem unnecessary or counterproductive to hematologists...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
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