keyword
MENU ▼
Read by QxMD icon Read
search

Skin breakdown

keyword
https://www.readbyqxmd.com/read/28314562/intermittent-vibration-protects-aged-muscle-from-mechanical-and-oxidative-damage-under-prolonged-compression
#1
Sing Wan Wong, Brian Chun Ho Cheung, Bruce Tak Keung Pang, Ateline Kwong, Anna Chung, Kenneth Ka Ho Lee, Arthur Fut Tak Mak
Deep tissue pressure ulcers, a serious clinical challenge originating in the muscle layer, are hardly detectable at the beginning. The challenge apparently occurs in aged subjects more frequently. As the ulcer propagates to the skin surface, it becomes very difficult to manage and can lead to fatal complications. Preventive measures are thus highly desirable. Although the complex pathological mechanisms have not been fully understood, prolonged and excessive physical challenges and oxidative stress are believed to be involved in the ulcer development...
February 27, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28301572/far-infrared-suppresses-skin-photoaging-in-ultraviolet-b-exposed-fibroblasts-and-hairless-mice
#2
Hui-Wen Chiu, Cheng-Hsien Chen, Yi-Jie Chen, Yung-Ho Hsu
Ultraviolet (UV) induces skin photoaging, which is characterized by thickening, wrinkling, pigmentation, and dryness. Collagen, which is one of the main building blocks of human skin, is regulated by collagen synthesis and collagen breakdown. Autophagy was found to block the epidermal hyperproliferative response to UVB and may play a crucial role in preventing skin photoaging. In the present study, we investigated whether far-infrared (FIR) therapy can inhibit skin photoaging via UVB irradiation in NIH 3T3 mouse embryonic fibroblasts and SKH-1 hairless mice...
2017: PloS One
https://www.readbyqxmd.com/read/28300084/alopecia-areata
#3
REVIEW
C Herbert Pratt, Lloyd E King, Andrew G Messenger, Angela M Christiano, John P Sundberg
Alopecia areata is an autoimmune disorder characterized by transient, non-scarring hair loss and preservation of the hair follicle. Hair loss can take many forms ranging from loss in well-defined patches to diffuse or total hair loss, which can affect all hair-bearing sites. Patchy alopecia areata affecting the scalp is the most common type. Alopecia areata affects nearly 2% of the general population at some point during their lifetime. Skin biopsies of affected skin show a lymphocytic infiltrate in and around the bulb or the lower part of the hair follicle in the anagen (hair growth) phase...
March 16, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28286313/characterization-and-expression-analysis-of-chitinase-genes-chit1-chit2-and-chit3-in-turbot-scophthalmus-maximus-l-following-bacterial-challenge
#4
Chengbin Gao, Xin Cai, Yu Zhang, Baofeng Su, Huanhuan Song, Chao Li
Chitinases are hydrolytic enzymes which have been employed to breakdown chitin coats of pathogenic microorganisms, thereby weaken the defense system of several pathogens and insects. In this regard, we identified the chitinase genes of turbot and characterized their expression patterns in mucosal tissues following Vibrio anguillarum and Streptococcus iniae challenge. In present study, transcripts of three chitinase genes (CHIT1, CHIT2 and CHIT3) were captured, as well as their protein structures and expression patterns following different bacterial infection were characterized...
March 9, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28273390/purpureocillium-lilacinum-tattoo-related-skin-infection-in-a-kidney-transplant-recipient
#5
Sonya A Trinh, Michael P Angarone
Purpureocillium lilacinum is an emerging pathogenic mold among immunocompromised hosts that causes cutaneous infections related to skin breakdown. We present the first reported case of P. lilacinum tattoo-related skin infection, to our knowledge. A kidney transplant recipient recently treated for acute cellular rejection presented with skin papules overlying a tattoo. Diagnosis was confirmed on culture, histology, and 18s ribosomal RNA polymerase chain reaction. The morphological features on culture characteristic of P...
March 8, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28267125/clinical-evaluation-of-a-skin-protectant-for-the-management-of-incontinence-associated-dermatitis-an-open-label-nonrandomized-prospective-study
#6
Mary R Brennan, Catherine T Milne, Marie Agrell-Kann, Bruce P Ekholm
PURPOSE: The purpose of this study was to evaluate the efficacy of an investigational skin protectant product at managing severe skin breakdown associated with incontinence. DESIGN: Open-label, nonrandomized, prospective study. SUBJECTS AND SETTING: The sample comprised 16 patients; inclusion criteria were: patients older than 18 years, cared for in the intensive care unit of a level I trauma center hospital or in long-term care facilities in the northeast region of the United States, and had incontinence-associated dermatitis (IAD)...
March 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/28265895/clinical-peritonitis-from-allergy-to-silicone-ventriculoperitoneal-shunt
#7
Michael Kurin, Kenneth Lee, Paul Gardner, Merritt Fajt, Chandraprakash Umapathy, Kenneth Fasanella
Silicones are inorganic compounds that have been used for the purpose of shunting ventricular fluid since the mid-20th century [1]. Complications of ventriculoperitoneal shunts have rarely been attributed to silicone allergy, with only a handful of cases reported in literature. The classic presentation of allergy to silicone ventriculoperitoneal shunt, i.e., abdominal pain with recurrent skin breakdown along the shunt tract, is nonspecific and difficult to distinguish clinically from other causes of shunt-related symptoms...
March 6, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28243502/ceeg-electrode-related-pressure-ulcers-in-acutely-hospitalized-patients
#8
Lidia M V R Moura, Thiago S Carneiro, David Kwasnik, Valdery F Moura, Christine S Blodgett, Joseph Cohen, Mary McKenna Guanci, Daniel B Hoch, John Hsu, Andrew J Cole, M Brandon Westover
BACKGROUND: Pressure ulcers resulting from continuous EEG (cEEG) monitoring in hospitalized patients have gained attention as a preventable medical complication. We measured their incidence and risk factors. METHODS: We performed an observational investigation of cEEG-electrode-related pressure ulcers (EERPU) among acutely ill patients over a 22-month period. Variables analyzed included age, sex, monitoring duration, hospital location, application methods, vasopressor usage, nutritional status, skin allergies, fever, and presence/severity of EERPU...
February 2017: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/28242899/investigation-on-temperature-fields-in-industrial-chilling-of-pork-legs-for-pdo-parma-ham-production-and-coupled-temperature-microbial-growth-simulation
#9
Massimiliano Rinaldi, Matteo Cordioli, Davide Barbanti
In the present work, temperature distribution within an industrial blast chiller with pork leg for Protected Designation of Origin Parma ham production was studied and the slowest cooling zone and the fastest cooling zone were recognized. Moreover, apparent heat transfer coefficients in both positions were calculated and resulted equal to 27.1 and 15.6 W m(-2) °C(-1), respectively. A finite element method model by distinguishing the three main components (skin, lean meat and bone) of the leg for the unsteady heat transfer during cooling was developed and validated against industrial chiller data...
January 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28174772/collagen-peptides-ameliorate-intestinal-epithelial-barrier-dysfunction-in-immunostimulatory-caco-2-cell-monolayers-via-enhancing-tight-junctions
#10
Qianru Chen, Oliver Chen, Isabela M Martins, Hu Hou, Xue Zhao, Jeffrey B Blumberg, Bafang Li
Dysfunction of the intestinal barrier plays a key role in the pathogenesis of inflammatory bowel disease (IBD) and multiple organ failure. The effect of Alaska pollock skin-derived collagen and its 3 tryptic hydrolytic fractions, HCP (6 kDa retentate), MCP (3 kDa retentate) and LCP (3 kDa permeate) on TNF-α induced barrier dysfunction was investigated in Caco-2 cell monolayers. TNF-α induced barrier dysfunction was significantly attenuated by the collagen and its peptide fractions, especially LCP, compared to TNF-α treated controls (P < 0...
February 8, 2017: Food & Function
https://www.readbyqxmd.com/read/28155806/human-immunology-of-tuberculosis
#11
Thomas J Scriba, Anna K Coussens, Helen A Fletcher
Immunology is a central theme when it comes to tuberculosis (TB). The outcome of human infection with Mycobacterium tuberculosis is dependent on the ability of the immune response to clear or contain the infection. In cases where this fails, the bacterium replicates, disseminates within the host, and elicits a pathologic inflammatory response, and disease ensues. Clinical presentation of TB disease is remarkably heterogeneous, and the disease phenotype is largely dependent on host immune status. Onward transmission of M...
January 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28152724/utilization-of-an-innovative-tool-to-improve-oncology-patient-outcomes
#12
Jessica O'Driscoll, Jaimika Patel, Marie Decker, Joanne McGovern
231 Background: Introduction of an electronic board can improve interdisciplinary communication to ensure early intervention and improve patient outcomes. Early detection and prevention is key. The early stages of physiologic demise may be demonstrated by subtle changes in the patient's vital signs. The purpose of this study was to implement a visual tool to indicate and update the acuity of patients on the oncology unit. The parameters displayed included vital signs, Hendrich, and Braden scale. The goal of the electronic board was to create a continuously accessible resource for the interdisciplinary team for rapid assessment of the patient's condition throughout rounds and all shifts...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28146605/stretch-for-the-treatment-and-prevention-of-contractures
#13
REVIEW
Lisa A Harvey, Owen M Katalinic, Robert D Herbert, Anne M Moseley, Natasha A Lannin, Karl Schurr
BACKGROUND: Contractures are a common complication of neurological and non-neurological conditions, and are characterised by a reduction in joint mobility. Stretch is widely used for the treatment and prevention of contractures. However, it is not clear whether stretch is effective. This review is an update of the original 2010 version of this review. OBJECTIVES: The aim of this review was to determine the effects of stretch on contractures in people with, or at risk of developing, contractures...
January 9, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28117478/mouthpiece-ventilation-in-duchenne-muscular-dystrophy-a-rescue-strategy-for-noncompliant-patients
#14
Giuseppe Fiorentino, Anna Annunziata, Rosa Cauteruccio, Gianfranco Scotto di Frega, Antonio Esquinas
Objective: To evaluate mouthpiece ventilation (MPV) in patients with Duchenne muscular dystrophy (DMD) who are noncompliant with noninvasive ventilation (NIV). Methods: We evaluated four young patients with DMD who had previously refused to undergo NIV. Each patient was reassessed and encouraged to try MPV. Results: The four patients tolerated MPV well and were compliant with NIV at home. MPV proved to be preferable and more comfortable than NIV with any other type of interface...
November 2016: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/28078772/skin-cleansing-and-emolliating-for-older-people-a-quasi-experimental-pilot-study
#15
Jill Brooks, Fiona Cowdell, Steven J Ersser, Eric D Gardiner
AIMS: The aims of this study were to (i) assess the effect of low-cost hygiene and emollient regimens on the skin barrier function (SBF) of people aged >65 year with xerosis (dry skin) on their lower legs; (ii) to assess the utility of portable measures of skin barrier function in terms of stratum corneum hydration (SCH) and transepidermal water loss (TEWL) in community settings; and iii) to provide evidence for a randomised controlled trial on the treatment of adults in a resource-poor country with dry skin on their lower legs which causes and exacerbates the skin disease podoconiosis (non-filarial elephantiasis)...
January 12, 2017: International Journal of Older People Nursing
https://www.readbyqxmd.com/read/28060178/assessment-of-splints-applied-for-pediatric-fractures-in-an-emergency-department-urgent-care-environment
#16
Joshua M Abzug, Brandon S Schwartz, Aaron J Johnson
BACKGROUND: Fractures are common in the pediatric population. The initial evaluation is rarely by an orthopaedic surgeon, but commonly an emergency room or urgent care center physician/extender. This typically involves splint application by a nonorthopaedist to immobilize the extremity and provide stabilization. Iatrogenic injuries from inappropriate splint placement are a potential public health and legal concern that can lead to complications. The primary purpose of this study was to prospectively evaluate the adequacy of all splints placed on patients who presented to a pediatric orthopaedic office; secondary outcomes included assessing prevalence and types of complications that were associated with inadequate splints...
January 5, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/27992393/manipulating-the-extracellular-matrix-an-animal-model-of-the-bladder-pain-syndrome
#17
Ifeoma Offiah, Athanasios Didangelos, Barry A OʼReilly, Stephen B McMahon
Bladder pain syndrome (BPS) is associated with breakdown of the protective uroepithelial barrier of the urinary bladder allowing urinary constituents access to bladder sensory neurons. Although there are several animal models of cystitis, none specifically relates to BPS. Here, we aimed to create such a model using enzymatic digestion of the barrier proteoglycans (PGs) in the rat. Twenty female Wistar rats were anaesthetized and transurethrally catheterized. Ten animals were treated with 0.25IU of intravesical chondroitinase ABC and heparanase III to digest chondroitin sulphate and heparin sulphate PGs, respectively...
January 2017: Pain
https://www.readbyqxmd.com/read/27984059/cruising-the-cellular-highways-how-human-papillomavirus-travels-from-the-surface-to-the-nucleus
#18
REVIEW
Stephen DiGiuseppe, Malgorzata Bienkowska-Haba, Lucile G Guion, Martin Sapp
The non-enveloped human papillomaviruses (HPVs) specifically target epithelial cells of the skin and mucosa. Successful infection requires a lesion in the stratified tissue for access to the basal cells. Herein, we discuss our recent progress in understanding binding, internalization, uncoating, and intracellular trafficking of HPV particles. Our focus will be on HPV type 16, which is the most common HPV type associated with various anogenital and oropharyngeal carcinomas. The study of HPV entry has revealed a number of novel cellular pathways utilized during infection...
March 2, 2017: Virus Research
https://www.readbyqxmd.com/read/27974399/serological-analysis-of-tuberculosis-in-goats-by-use-of-the-enferplex-caprine-tb-multiplex-test
#19
Amanda O'Brien, Clare Whelan, John B Clarke, Alastair Hayton, Neil J Watt, Gordon D Harkiss
Tuberculosis in goats is usually diagnosed clinically, at postmortem, or by a positive skin test. However, none of these approaches detects all infected animals. Serology offers an additional tool to identify infected animals missed by current tests. We describe the use of the Enferplex Caprine TB serology test to aid the management of a large dairy goat herd undergoing a tuberculosis breakdown. Initial skin and serology testing showed that IgG antibodies were present in both serum and milk from 100% of skin test-positive animals and in serum and milk from 77...
February 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/27941234/thermal-symmetry-of-healthy-feet-a-precursor-to-a-thermal-study-of-diabetic-feet-prior-to-skin-breakdown
#20
Audrey Macdonald, Nina Petrova, Suhail Ainarkar, John Allen, Peter Plassmann, Aaron Whittam, John Bevans, Francis Ring, Ben Kluwe, Rob Simpson, Leon Rogers, Graham Machin, Mike Edmonds
Early identification of areas of inflammation may aid prevention of diabetic foot ulcers. A new bespoke thermal camera system has been developed to thermally image feet at risk. Hotspots (areas at least 2.2 °C hotter than the contralateral site) may indicate areas of inflammation prior to any apparent visual signs. This article describes the thermal pattern and symmetry of 103 healthy pairs of feet. 68% of participants were thermally symmetric at the 33 foot sites measured. 32% of participants had at least one hotspot, but hotspots overall only accounted for 5% of the measurements made...
January 2017: Physiological Measurement
keyword
keyword
52874
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"