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https://www.readbyqxmd.com/read/28808084/glycopyrronium-for-severe-drooling-in-children
#1
(no author information available yet)
Drooling of saliva is common in children with physical, intellectual and learning disability, and with poor neuromuscular coordination and oral control.(1) It can cause skin breakdown, damage to clothes and equipment and psychosocial problems for the child and family. For many years, glycopyrronium has been prescribed off-label using the injection solution given orally or tablets crushed and suspended in water, or as unlicensed products that were imported or manufactured as pharmaceutical specials.(2,3) In January 2017, a glycopyrronium oral solution (Sialanar-Proveca Limited) became available in the UK as the first licensed product for the treatment of severe drooling (sialorrhoea) in children and adolescents aged 3 years and older with chronic neurological disorders...
August 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/28807988/high-flow-nasal-cannula-therapy-versus-intermittent-noninvasive-ventilation-in-obese-subjects-after-cardiothoracic-surgery
#2
François Stéphan, Laurence Bérard, Saida Rézaiguia-Delclaux, Priscilla Amaru
BACKGROUND: Obese patients are considered at risk of respiratory failure after cardiothoracic surgery. High-flow nasal cannula has demonstrated its non-inferiority after cardiothoracic surgery compared to noninvasive ventilation (NIV), which is the recommended treatment in obese patients. We hypothesized that NIV was superior to high-flow nasal cannula for preventing or resolving acute respiratory failure after cardiothoracic surgery in this population. METHODS: We performed a post hoc analysis of a randomized, controlled trial...
August 14, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28779991/surgical-management-of-adult-acquired-buried-penis-escutcheonectomy-scrotectomy-and-penile-split-thickness-skin-graft
#3
Thomas W Fuller, Katherine Theisen, Paul Rusilko
OBJECTIVE: To demonstrate the surgical management of adult acquired buried penis (AABP). Affected patients have poor sexual function, urinary dribbling with subsequent skin breakdown, mood disturbance, lichen sclerosus with subsequent urethral stricture, and poor quality of life. Previous efforts have described limited repairs including an isolated resection of the escutcheon, which unfortunately often leads to reburying. We present a more extensive surgical repair including escutcheonectomy, scrotoplasty, and penile split-thickness skin graft (STSG) to provide a durable definitive repair...
July 6, 2017: Urology
https://www.readbyqxmd.com/read/28770671/marine-algae-as-attractive-source-to-skin-care
#4
Jean-Yves Berthon, Rachida Nachat-Kappes, Mathieu Bey, Jean-Paul Cadoret, Isabelle Renimel, Edith Filaire
As the largest organ in the human body, the skin has multiple functions of which one of the most important is the protection against various harmful stressors. The keratinised stratified epidermis and an underlying thick layer of collagen-rich dermal connective tissues are important components of the skin. The environmental stressors such as ultraviolet radiation (UVR) and pollution increase the levels of reactive oxygen species (ROS), contributing to clinical manifestations such as wrinkle formation and skin aging...
June 2017: Free Radical Research
https://www.readbyqxmd.com/read/28762881/porcine-ischemic-wound-healing-model-for-preclinical-testing-of-degradable-biomaterials
#5
Prarthana Patil, John R Martin, Samantha M Sarett, Alonda C Pollins, Nancy L Cardwell, Jeffrey M Davidson, Scott Guelcher, Lillian Nanney, Craig Duvall
Impaired wound healing that mimics chronic human skin pathologies is difficult to achieve in current animal models, hindering testing and development of new therapeutic biomaterials that promote wound healing. Here we describe a refinement and simplification of the porcine ischemic wound model that increases the size and number of experimental sites per animal. By comparing three flap geometries, we adopted a superior configuration (15 cm x 10 cm) that enabled testing of twenty 1 cm<sup>2</sup> square wounds in each animal: 8 total ischemic wounds within 4 bipedicle flaps and 12 non-ischemic wounds...
August 1, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28736002/high-flow-nasal-cannula-versus-noninvasive-ventilation-for-treatment-of-acute-hypoxemic-respiratory-failure-in-renal-transplant-recipients
#6
G Tu, H He, K Yin, M Ju, Y Zheng, D Zhu, Z Luo
OBJECTIVE: This study aimed to evaluate the outcomes of high-flow nasal cannula (HFNC) oxygen therapy compared with noninvasive ventilation (NIV) for the treatment of acute hypoxemic respiratory failure in renal transplant recipients. METHODS: Data were retrospectively collected from a tertiary intensive care unit (ICU) from July 1, 2011, to September 31, 2015. All renal recipients who had acute respiratory failure at that period of time were classified into the HFNC or NIV group depending on the initial form of respiratory support...
July 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28719546/fracture-table-application-for-pediatric-femur-fractures-incidence-and-risk-factors-associated-with-adverse-outcomes
#7
Brian A Kelly, Manahil Naqvi, Emily S Rademacher, Patricia E Miller, Daniel J Hedequist, Michael P Glotzbecker, Travis H Matheney, Benjamin J Shore
BACKGROUND: Flexible elastic nails, submuscular plating, and rigid locked intramedullary nails are common methods of fixation for pediatric femur fractures (PFF) in which the fracture table is used to aid reduction. Little is known about complications associated with fracture table application in PFF. The purpose of this study was to determine the incidence and risk factors associated with adverse outcomes related to fracture table application for the treatment of PFF. METHODS: A retrospective chart review of all children (younger than 18 y) treated for a femur fracture with the use of the fracture table between 2004 and 2015 at a single tertiary pediatric hospital was performed...
July 17, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28719403/passive-transcutaneous-bone-conduction-hearing-implants-a-systematic-review
#8
Timothy Cooper, Brendan McDonald, Allan Ho
OBJECTIVE: To systematically review the literature on currently available passive transcutaneous bone conduction hearing implants (pTCBI) with regard to complications, audiological outcomes, and quality-of-life scores. DATA SOURCES: MEDLINE, EMBASE, Scopus, and Cochrane Library. STUDY SELECTION: All identified English-language articles reporting on the implantation of currently available pTCBI's and their complications. Both pediatric and adult patients were included...
July 17, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28709564/current-and-emerging-concepts-in-atopic-dermatitis-pathogenesis
#9
Marguerite Sullivan, Nanette B Silverberg
Atopic dermatitis is a common skin disorder with a complex, evolving pathogenesis. Research on the pathogenesis has shifted from focusing primarily on generalized immune system abnormalities in T helper 1/T helper 2 (Th1/Th2) activity to more targeted immune and skin barrier abnormalities contributing to the overall phenotype. Specific signaling pathways recently implicated in atopic dermatitis include production of interleukin (IL) 4 and IL-13, which promote immunoglobulin E production, Th17 and Th22 cells, and production of cytokines...
July 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28703365/phototherapy-in-systemic-sclerosis-review
#10
REVIEW
Suteeraporn Chaowattanapanit, Charoen Choonhakarn, Chingching Foocharoen, Narachai Julanon
Systemic scleroderma-also known as systemic sclerosis (SSc)-is a chronic systemic connective tissue disease characterized by collagen deposition in cutaneous and internal organs, leading to skin sclerosis and multiple organ fibrosis. The pathogenesis is complex and remains poorly understood. Treatment is based on organ involvement and requires a multidisciplinary approach. Skin sclerosis can cause disability, leading to decreasing quality of life. Various systemic antifibrotic therapies have been used; however, most have unsatisfactory results...
July 13, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28698756/treatment-of-decubitis-ulcer-stage-iv-in-the-patient-with-polytrauma-and-vertical-share-pelvic-fracture-diagnosed-entherocollitis-and-deep-wound-infection-with-clostridium-difficile-with-combined-negative-pressure-wound-therapy-npwt-and-faecal-management-system
#11
Slavcho Stojmenski, Igor Merdzanovski, Andrej Gavrilovski, Sofija Pejkova, Gjorge Dzokic, Smilja Tudzarova
AIM: The aim of this paper was to present a case with the successful treatment of decubitis ulcer stage IV in the patient with polytrauma and vertical share pelvic fracture and diagnosed entherocollitis combined with deep wound infection with Clostridium difficile treated with combined Negative Pressure Wound Therapy (NPWT) and faecal management system. CASE REPORT: Patient D.S.1967 treated on Traumatology Clinic after tentamen suicide on 9.2.2015 with diagnosis: brain contusion; contusion of thoracal space; vertical share pelvic fracture; open fracture type II of the right calcaneus; fracture of the left calcaneus; fracture on the typical place of the left radius; fracture of the right radius with dislocation...
June 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28695413/-process-disturbances-and-improvements-of-wound-healing
#12
S Trainotti, M Scheithauer
Skin damage induces the wound healing process which leads to primary or secondary healing in three sequential, partially overlapping phases, due to interaction among different cells and secretion of pro- and anti-inflammatory mediators. The subtle equilibrium among repair and breakdown can be disturbed by different local and systemic factors causing impairment or even stagnancy of a phase with the effect of chronic wounds or deficient healing. Various surgical and nonsurgical instruments can be used to promote disturbed towards physiologic healing and restore the integrity of the organism's protective layer...
July 10, 2017: HNO
https://www.readbyqxmd.com/read/28687935/update-of-ablative-fractionated-lasers-to-enhance-cutaneous-topical-drug-delivery
#13
REVIEW
Jill S Waibel, Ashley Rudnick, Deborah R Shagalov, Danielle M Nicolazzo
Ablative fractional lasers (AFXL) enhance uptake of therapeutics and this newly emerging field is called laser-assisted drug delivery (LAD). This new science has emerged over the past decade and is finding its way into clinical practice. LAD is poised to change how medicine delivers drugs. Topical and systemic application of pharmaceutical agents for therapeutic effect is an integral part of medicine. With topical therapy, the stratum corneum barrier of the skin impairs the ability of drugs to enter the body...
July 7, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28650945/treatment-approach-for-infection-of-healed-fractures-after-internal-fixation
#14
Joshua M Lawrenz, Salvatore J Frangiamore, Ajinkya A Rane, W Alex Cantrell, Heather A Vallier
OBJECTIVE: To review the efficacy of a treatment approach for patients with infection and colonized implants after open reduction and internal fixation of fractures. DESIGN: Retrospective case series. SETTING: Level one trauma center. PATIENTS: Twenty patients were treated for wound infection with colonized implants after open reduction and internal fixation. INTERVENTION: Surgical debridement, removal of implants and a short post-operative oral antibiotic course...
June 15, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28633785/the-lisfranc-amputation-a-more-reliable-level-of-amputation-with-proper-intraoperative-tendon-balancing
#15
Christopher J Greene, Christopher Bibbo
Traditional transmetatarsal amputations are a reliable level of amputation. However, amputations at the Lisfranc level have met with limited success owing to improper biomechanics resulting from tendon imbalance, ultimately leading to foot deformity positions and an unstable soft tissue envelope with ensuing skin breakdown, infection, and below-the-knee amputation. We describe proper tendon rebalancing that results in improved biomechanics and a more reliable and stable amputation at the more proximal Lisfranc level...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28617750/skin-and-wound-care-in-lymphedema-patients-a-taxonomy-primer-and-literature-review
#16
Caroline E Fife, Wade Farrow, Adelaide A Hebert, Nathan C Armer, Bob R Stewart, Janice N Cormier, Jane M Armer
BACKGROUND: Lymphedema is a condition of localized protein-rich swelling from damaged or malfunctioning lymphatics. Because the immune system is compromised, there is a high risk of infection. Infection in patients with lymphedema may present in a variety of ways. OBJECTIVE: The goals of this review were to standardize the terminology of skin breakdown in the context of lymphedema, synthesize the available information to create best practice recommendations in support of the American Lymphedema Framework Project update to its Best Practices document, and create recommendations for further research...
July 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28602246/pressure-signatures-can-influence-tissue-response-for-individuals-supported-on-an-alternating-pressure-mattress
#17
C Y Chai, O Sadou, P R Worsley, D L Bader
Prolonged mechanical loading can lead to the breakdown of skin and underlying tissues which can, in turn, develop into a pressure ulcer. The benefits of pressure relief and/or redistribution to minimise risk have been well documented. Manufacturers have developed alternating air pressure mattresses (APAMs) to provide periodic relief for individuals on prolonged bed-rest. The present study describes the development of a control system, termed Pneumatic Manager which can vary the signature of an APAM, namely its pressure amplitude, cell profile and cycle period...
May 10, 2017: Journal of Tissue Viability
https://www.readbyqxmd.com/read/28594761/wound-complication-rates-after-staples-or-suture-for-midline-vertical-skin-closure-in-obese-women-a-randomized-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
Lindsay M Kuroki, Mary M Mullen, L Stewart Massad, Ningying Wu, Jingxia Liu, David G Mutch, Matthew A Powell, Andrea R Hagemann, Premal H Thaker, Carolyn K McCourt, Akiva P Novetsky
OBJECTIVE: To compare wound complication rates after skin closure with staples and subcuticular suture in obese gynecology patients undergoing laparotomy through a midline vertical incision. METHODS: In this randomized controlled trial, women with body mass indexes (BMIs) of 30 or greater undergoing surgery by a gynecologic oncologist through a midline vertical incision were randomized to skin closure with staples or subcuticular 4-0 monofilament suture. The primary outcome was the rate of wound complication, defined as the presence of a wound breakdown, or infection, within 8 weeks postoperatively...
July 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28586092/quantitative-skin-assessment-using-spatial-frequency-domain-imaging-sfdi-in-patients-with-or-at-high-risk-for-pressure-ulcers
#19
Amr Yafi, Fuad K Muakkassa, Tejasvi Pasupneti, Judy Fulton, David J Cuccia, Amaan Mazhar, Kimberly N Blasiole, Eliot N Mostow
BACKGROUND AND OBJECTIVE: Pressure ulcers (PU) are a significant problem facing the health system in the United States. Here, we present preliminary case studies demonstrating feasibility of Spatial Frequency Domain Imaging (SFDI) to assess skin status in high-risk populations and pre-existing wounds. SFDI is a wide-field non-contact optical imaging technology that uses structured light to obtain tissue optical properties and of tissue constituents. This study aims to determine the fit of SFDI for PU care and determine the next steps...
June 6, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28583488/non-invasive-methods-to-maintain-cervical-spine-position-after-pediatric-tracheal-resections
#20
Kahren K Aydinyan, Jonathan D Day, Gina M Troiano, G Paul Digoy
OBJECTIVES: To present our experience with two methods of neck stabilization after pediatric tracheal resection with primary anastomosis as possible alternatives to the traditional chest-chin suture. METHODS: Children undergoing tracheal resection and/or cricotracheal resection with anastomosis under tension were placed in cervical spine flexion postoperatively with either a chest-chin (Grillo) suture, an Aspen cervical collar or Trulife Johnson cervical-thoracic orthosis (CTO)...
July 2017: International Journal of Pediatric Otorhinolaryngology
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