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https://www.readbyqxmd.com/read/28239638/brain-amyloid-in-preclinical-alzheimer-s-disease-is-associated-with%C3%A2-increased-driving-risk
#1
Brian R Ott, Richard N Jones, Richard B Noto, Don C Yoo, Peter J Snyder, Justine N Bernier, David B Carr, Catherine M Roe
INTRODUCTION: Postmortem studies suggest that fibrillar brain amyloid places people at higher risk for hazardous driving in the preclinical stage of Alzheimer's disease (AD). METHODS: We administered driving questionnaires to 104 older drivers (19 AD, 24 mild cognitive impairment, and 61 cognitive normal) who had a recent (18)F-florbetapir positron emission tomography scan. We examined associations of amyloid standardized uptake value ratios with driving behaviors: traffic violations or accidents in the past 3 years...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28226253/modeling-single-vehicle-run-off-road-crash-severity-in-rural-areas-accounting-for-unobserved-heterogeneity-and-age-difference
#2
Linfeng Gong, Wei David Fan
This study investigates factors that significantly contribute to the severity of driver injuries resulting from single-vehicle run-off-road (SV ROR) crashes. A mixed logit model approach is employed to explore the potential unobserved heterogeneous effects associated with each age group: young (ages 16-24), middle-aged (ages 25-65), and older drivers (ages over 65). Likelihood ratio tests indicated that the development of separate injury severity models for each age group is statistically superior to estimating a single model using all data...
February 19, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28223244/frailty-and-sarcopenia-the-potential-role-of-an-aged-immune-system
#3
REVIEW
Daisy Wilson, Thomas Jackson, Elizabeth Sapey, Janet M Lord
Frailty is a common negative consequence of ageing. Sarcopenia, the syndrome of loss of muscle mass, quality and strength, is more common in older adults and has been considered a precursor syndrome or the physical manifestation of frailty. The pathophysiology of both syndromes is incompletely described with multiple causes, inter-relationships and complex pathways proposed. Age-associated changes to the immune system (both immunesenescence, the decline in immune function with ageing, and inflammageing, a state of chronic inflammation) have been suggested as contributors to sarcopenia and frailty but a direct causative role remains to be established...
February 20, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/28218593/video-feedback-intervention-to-enhance-the-safety-of-older-drivers-with-cognitive-impairment
#4
Brian R Ott, Jennifer D Davis, Kimberly Bixby
OBJECTIVE: To demonstrate that g-force technology can be used to help older adults with cognitive impairment improve their driving safety as part of an in-car video feedback intervention. METHOD: Unsafe driving events triggered g-forces leading to capture of video clips. The program included 3 mo of monitoring without intervention, 3 mo of intervention (weekly written progress reports, a DVD of unsafe driving events, and weekly telephone contacts), and 3 mo of postintervention monitoring...
March 2017: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/28198091/impact-of-chronic-kidney-disease-on-2-year-clinical-outcomes-in-patients-treated-with-6-month-or-24-month-dapt-duration-an-analysis-from-the-prodigy-trial
#5
Giuseppe Gargiulo, Andrea Santucci, Raffaele Piccolo, Anna Franzone, Sara Ariotti, Andrea Baldo, Giovanni Esposito, Aris Moschovitis, Stephan Windecker, Marco Valgimigli
OBJECTIVES: To assess whether moderate-to-severe CKD is a treatment modifier for benefit or harm in patients randomly allocated to 24-month versus 6-month DAPT. BACKGROUND: It is still unclear whether chronic kidney disease CKD should impact on the decision-making on optimal duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI). METHODS AND RESULTS: PRODIGY trial randomized 1970 all-comer patients at 24-month versus 6-month DAPT after PCI...
February 15, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28193794/alcohol-policies-and-alcohol-related-motor-vehicle-crash-fatalities-among-young-people-in-the-us
#6
Scott E Hadland, Ziming Xuan, Vishnudas Sarda, Jason Blanchette, Monica H Swahn, Timothy C Heeren, Robert B Voas, Timothy S Naimi
BACKGROUND: Motor vehicle crashes (MVCs) are a leading cause of death among young people in the United States. We examined the relationship between states' alcohol policy environments and alcohol-related MVC fatalities among children, adolescents, and young adults under the minimum legal drinking age of 21 years. METHODS: We used the Alcohol Policy Scale (APS), an assessment of 29 alcohol policies across 50 states and Washington, DC, developed with the assistance of an interdisciplinary Delphi panel...
February 13, 2017: Pediatrics
https://www.readbyqxmd.com/read/28192260/risk-factors-and-independent-predictors-of-30-day-readmission-for-altered-mental-status-after-elective-spine-surgery-for-spine-deformity-a-single-institutional-study-of-1090-patients
#7
Aladine A Elsamadicy, Owoicho Adogwa, Gireesh B Reddy, Amanda Sergesketter, Hunter Warwick, Terrell Jones, Joseph Cheng, Carlos A Bagley, Isaac O Karikari
BACKGROUND: Altered Mental Status (AMS) has been associated with inferior surgical outcomes. The factors leading to AMS after spine surgery are unknown. The aim of this study is to determine the risk factors and independent predictors of 30-day readmission for AMS in spine deformity patients after undergoing elective spine surgery. METHODS: The medical records of 1090 adult (≥18 years old) spine deformity patients undergoing elective spine surgery at a major academic institution from 2005 to 2015 were reviewed...
February 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28181711/a-systematic-review-of-intervention-approaches-for-driving-cessation-in-older-adults
#8
REVIEW
Mark J Rapoport, Duncan H Cameron, Sarah Sanford, Gary Naglie
OBJECTIVE: The aim of this project was to review the literature on interventions aimed at facilitating driving cessation in older adults, with and without dementia. METHODS: A literature search was performed using the databases MEDLINE, CINAHL, Cochrane Central, Embase, and PsycINFO, from 1994 to September 2014. Two independent raters screened articles for inclusion and extracted study data. We only included articles if they directly addressed the topic of intervention approaches to facilitate the process of driving cessation in older adults or to support the adaptation of older adults who have had to stop driving and included a control group...
February 9, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28176925/influence-of-medication-risks-and-benefits-on-treatment-preferences-in-older-patients-with-multimorbidity
#9
Gillian E Caughey, Kirsty Tait, Agnes I Vitry, Sepehr Shakib
Multimorbidity is associated with use of multiple medicines, increased risk of adverse events and treatment conflicts. This study aimed to examine how older patients with multimorbidity and clinicians balance the benefits and harms associated with a medication and in the presence of competing health outcomes. Interviews were conducted with 15 participants aged ≥65 years with 2 or more chronic conditions. Three clinical scenarios were presented to understand patient preference to take a medicine according to i) degree of benefit, ii) type of adverse event and impact on daily living and iii) influence of comorbid conditions as competing health outcomes...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28167421/self-reported-vs-state-recorded-motor-vehicle-collisions-among-older-community-dwelling-individuals
#10
B A Singletary, A N Do, J P Donnelly, C Huisingh, M T Mefford, R Modi, F L Mondesir, Y Ye, C Owsley, G McGwin
INTRODUCTION: Motor vehicle collisions (MVCs) continue to place an increased burden on both individuals and health care systems. Self-reported and state-recorded police reports are the most common methods for MVC evaluation in epidemiologic studies, with varying degrees of agreement of information when compared in previous studies. The objective of the current study is to address the differences in MVC reporting and provide a more robust measure of the agreement between self-reported and state-recorded MVCs in a community dwelling population of older adults...
February 3, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28161152/biogeographical-patterns-of-myrcia-s-l-myrtaceae-and-their-correlation-with-geological-and-climatic-history-in-the-neotropics
#11
Matheus Fortes Santos, Eve Lucas, Paulo Takeo Sano, Sven Buerki, Vanessa Graziele Staggemeier, Félix Forest
Many recent studies discuss the influence of climatic and geological events in the evolution of Neotropical biota by correlating these events with dated phylogenetic hypotheses. Myrtaceae is one of the most diverse Neotropical groups and it therefore a good proxy of plant diversity in the region. However, biogeographic studies on Neotropical Myrtaceae are still very limited. Myrcia s.l. is an informal group comprising three accepted genera (Calyptranthes, Marlierea and Myrcia) making up the second largest Neotropical group of Myrtaceae, totalling about 700 species distributed in nine subgroups...
March 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28160188/disparities-in-hypertension-associated-with-limited-english-proficiency
#12
Eun Ji Kim, Taekyu Kim, Michael K Paasche-Orlow, Adam J Rose, Amresh D Hanchate
BACKGROUND: Limited English proficiency (LEP) is associated with poor health status and worse outcomes. OBJECTIVE: To examine disparities in hypertension between National Health and Nutrition Examination Survey (NHANES) respondents with LEP versus adequate English proficiency. DESIGN: Retrospective analysis of multi-year survey data. PARTICIPANTS: Adults 18 years of age and older who participated in the NHANES survey during the period 2003-2012...
February 3, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28159871/trends-in-the-diagnosis-of-vitamin-d-deficiency
#13
Emre Basatemur, Laura Horsfall, Louise Marston, Greta Rait, Alastair Sutcliffe
BACKGROUND: Vitamin D has attracted considerable interest in recent years, and health care providers have reported large increases in vitamin D test requests. However, rates of diagnosis of vitamin D deficiency in clinical practice have not been investigated. We examined trends in diagnosis of vitamin D deficiency in children in England over time, and by sociodemographic characteristics. METHODS: Cohort study using primary care records of 711 788 children aged 0 to 17 years, from the Health Improvement Network database...
February 3, 2017: Pediatrics
https://www.readbyqxmd.com/read/28152028/serum-phosphorus-levels-and-risk-of-incident-dementia
#14
Tingting Li, Yan Xie, Benjamin Bowe, Hong Xian, Ziyad Al-Aly
Higher serum phosphorous is associated with cerebral small vessel disease, an important driver of cognitive decline and dementia. Whether serum phosphorous, a potentially modifiable parameter, associates with risk of incident dementia is not known. We aimed to examine the association between serum phosphorous and risk of incident dementia and to determine if the association is modified by age. We used the United States Department of Veterans Affairs national databases to build a longitudinal observational cohort of US veterans without prior history of dementia and with at least one outpatient serum phosphorus between October 2008 and September 2010 and followed them until September 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28142014/is-there-an-occupational-status-gradient-in-the-development-of-periodontal-disease-in-japanese-workers-a-5-year-prospective-cohort-study
#15
Koichiro Irie, Toru Yamazaki, Saori Yoshii, Hideo Takeyama, Yoshihiro Shimazaki
BACKGROUND: Development of periodontal disease (PD) may be affected by socioeconomic status. This study examined the relationship between occupational status and PD in a 5-year prospective cohort of Japanese workers. METHODS: In total, 19,633 participants had initial examinations at the Aichi Health Promotion Foundation, of whom 8210 participants aged 20 years or older did not have PD. Follow-up examinations were conducted for 3757 participants, accounting for 45...
February 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28137967/selenomethionine-mitigates-cognitive-decline-by-targeting-both-tau-hyperphosphorylation-and-autophagic-clearance-in-an-alzheimer-s-disease-mouse-model
#16
Zhong-Hao Zhang, Qiu-Yan Wu, Rui Zheng, Chen Chen, Yao Chen, Qiong Liu, Peter R Hoffmann, Jia-Zuan Ni, Guo-Li Song
: Tau pathology was recently identified as a key driver of disease progression and an attractive therapeutic target in Alzheimer's disease (AD). Selenomethionine (Se-Met), a major bioactive form of selenium (Se) in organisms with significant antioxidant capacity, reduced the levels of total tau and hyperphosphorylated tau and ameliorated cognitive deficits in younger triple transgenic AD (3xTg-AD) mice. Whether Se-Met has a similar effect on tau pathology and the specific mechanism of action in older 3xTg-AD mice remains unknown...
January 30, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28119840/relationship-between-cognitive-perceptual-abilities-and-accident-and-penalty-histories-among-elderly-korean-drivers
#17
Jung Ah Lee, Hyun Choi, Dong-A Kim, Bum-Suk Lee, Jae Jin Lee, Jae Hyuk Bae, Mun Hee Lim, Jin-Ju Kim
OBJECTIVE: To investigate the relationship between cognitive perceptual abilities of elderly drivers based on the Cognitive Perceptual Assessment for Driving (CPAD) test and their accident and penalty histories. METHODS: A total of 168 elderly drivers (aged ≥65 years) participated in the study. Participant data included CPAD scores and incidents of traffic accidents and penalties, attained from the Korea Road Traffic Authority and Korea National Police Agency, respectively...
December 2016: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28115977/efficacy-of-a-novel-formulation-of-l-carnitine-creatine-and-leucine-on-lean-body-mass-and-functional-muscle-strength-in-healthy-older-adults-a-randomized-double-blind-placebo-controlled-study
#18
Malkanthi Evans, Najla Guthrie, John Pezzullo, Toran Sanli, Roger A Fielding, Aouatef Bellamine
BACKGROUND: Progressive decline in skeletal muscle mass and function are growing concerns in an aging population. Diet and physical activity are important for muscle maintenance but these requirements are not always met. This highlights the potential for nutritional supplementation. As a primary objective, we sought to assess the effect of a novel combination of L-Carnitine, creatine and leucine on muscle mass and performance in older subjects. METHOD: Forty-two healthy older adults aged 55-70 years were randomized to receive either a novel L-Carnitine (1500 mg), L-leucine (2000 mg), creatine (3000 mg), Vitamin D3 (10 μg) (L-Carnitine-combination) product (n = 14), L-Carnitine (1500 mg) (n = 14), or a placebo (n = 14) for eight weeks...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28115437/driving-and-dementia-efficient-approach-to-driving-safety-concerns-in-family-practice
#19
REVIEW
Linda Lee, Frank Molnar
OBJECTIVE: To provide primary care physicians with an approach to driving safety concerns when older persons present with memory difficulties. SOURCES OF INFORMATION: The approach is based on an accredited memory clinic training program developed by the Centre for Family Medicine Primary Care Collaborative Memory Clinic. MAIN MESSAGE: One of the most challenging aspects of dementia care is the assessment of driving safety. Drivers with dementia are at higher risk of motor vehicle collisions, yet many drivers with mild dementia might be safely able to continue driving for several years...
January 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28103394/measuring-patient-engagement-which-health-care-engagement-behaviors-are-important-to-patients
#20
Huey-Ming Tzeng, James Marcus Pierson
AIM(S): This study identified patient health care engagement behaviors that are important to community-dwelling adult patients living in the southern region of the USA. BACKGROUND: Patient engagement has been identified as a key driver for containing health care costs, but the public and health care professionals lack a scientific understanding of patient engagement. A valid tool is needed for prompting patients to discuss health activities with their health care providers and to obtain support...
January 19, 2017: Journal of Advanced Nursing
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