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https://www.readbyqxmd.com/read/28334085/environmental-niche-divergence-among-three-dune-shrub-sister-species-with-parapatric-distributions
#1
Sergio Chozas, Rosa M Chefaoui, Otília Correia, Raúl Bonal, Joaquín Hortal
Background and Aims: The geographical distributions of species are constrained by their ecological requirements. The aim of this work was to analyse the effects of environmental conditions, historical events and biogeographical constraints on the diversification of the three species of the western Mediterranean shrub genus Stauracanthus , which have a parapatric distribution in the Iberian Peninsula. Methods: Ecological niche factor analysis and generalized linear models were used to measure the response of all Stauracanthus species to the environmental gradients and map their potential distributions in the Iberian Peninsula...
February 20, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28332632/loss-of-chromosome-y-leads-to-down-regulation-of-kdm5d-and-kdm6c-epigenetic-modifiers-in-clear-cell-renal-cell-carcinoma
#2
Madeleine Arseneault, Jean Monlong, Naveen S Vasudev, Ruhina S Laskar, Maryam Safisamghabadi, Patricia Harnden, Lars Egevad, Nazanin Nourbehesht, Pudchalaluck Panichnantakul, Ivana Holcatova, Antonin Brisuda, Vladimir Janout, Helena Kollarova, Lenka Foretova, Marie Navratilova, Dana Mates, Viorel Jinga, David Zaridze, Anush Mukeria, Pouria Jandaghi, Paul Brennan, Alvis Brazma, Jorg Tost, Ghislaine Scelo, Rosamonde E Banks, Mark Lathrop, Guillaume Bourque, Yasser Riazalhosseini
Recent genomic studies of sporadic clear cell renal cell carcinoma (ccRCC) have uncovered novel driver genes and pathways. Given the unequal incidence rates among men and women (male:female incidence ratio approaches 2:1), we compared the genome-wide distribution of the chromosomal abnormalities in both sexes. We observed a higher frequency for the somatic recurrent chromosomal copy number variations (CNVs) of autosomes in male subjects, whereas somatic loss of chromosome X was detected exclusively in female patients (17...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28325164/development-of-a-decision-making-tool-for-reporting-drivers-with-mild-dementia-and-mild-cognitive-impairment-to-transportation-administrators
#3
Duncan H Cameron, Carla Zucchero Sarracini, Linda Rozmovits, Gary Naglie, Nathan Herrmann, Frank Molnar, John Jordan, Anna Byszewski, David Tang-Wai, Jamie Dow, Christopher Frank, Blair Henry, Nicholas Pimlott, Dallas Seitz, Brenda Vrkljan, Rebecca Taylor, Mario Masellis, Mark J Rapoport
BACKGROUND: Driving in persons with dementia poses risks that must be counterbalanced with the importance of the care for autonomy and mobility. Physicians often find substantial challenges in the assessment and reporting of driving safety for persons with dementia. This paper describes a driving in dementia decision tool (DD-DT) developed to aid physicians in deciding when to report older drivers with either mild dementia or mild cognitive impairment to local transportation administrators...
March 22, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28319725/antiestrogen-use-in-breast-cancer-patients-reduces-the-risk-of-subsequent-lung-cancer-a-population-based-study
#4
Sung-Chao Chu, Chia-Jung Hsieh, Tso-Fu Wang, Mun-Kun Hong, Tang-Yuan Chu
BACKGROUND: There is accumulating epidemiological and preclinical evidence that estrogen might be a driver of lung cancer. Breast cancer survivors can offer a unique patient cohort to examine the effect of antiestrogen therapy on lung cancer carcinogenesis because many of these women would have received long-term selective estrogen receptor modulators (SERMs) and/or aromatase inhibitors (AIs) as adjuvant treatment. Our hypothesis is that estrogens play a role in lung cancer development, and that antiestrogen therapy would affect the incidence of subsequent lung cancer among breast cancer survivors...
March 17, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28318430/factors-contributing-to-intercity-commercial-bus-drivers-crash-involvement-risk
#5
Mohammad Mehdi Besharati, Ali Tavakoli Kashani
The aim of this study was to examine the influence of demographic, environmental and occupational factors as well as behavioural characteristics of intercity bus drivers, on their crash involvement risk. A total number of 107 intercity bus drivers from Tehran, Iran were participated in the study. Logistic regression model suggested that smokers, those who drive during night to morning, less experienced drivers as well as those who operate older buses are more likely to be involved in crashes. In addition, one unit increase in the weekly driving hours might significantly increase the drivers' crash involvement risk...
March 20, 2017: Archives of Environmental & Occupational Health
https://www.readbyqxmd.com/read/28302103/age-and-the-risk-of-all-terrain-vehicle-related-injuries-in-children-and-adolescents-a-cross-sectional-study
#6
Lianne McLean, Kelly Russell, Steven McFaull, Lynne Warda, Milton Tenenbein, Jonathan McGavock
BACKGROUND: The study was designed to determine if youth <16 years are at a greater risk of serious injuries related to all-terrain vehicle (ATV) use compared to older adolescents and adults. METHODS: We performed cross sectional study of children and adults presenting to pediatric and adult emergency departments between 1990 and 2009 in Canada. The primary exposure variable was age <16 years and the primary outcome measure was moderate to serious injury determined from physician report of type and severity of injury...
March 17, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28288729/knowledge-attitudes-and-practices-around-drinking-and-driving-in-cambodia-2010-2012
#7
A M Bachani, C B Risko, C Gnim, S Coelho, A A Hyder
OBJECTIVE: Road traffic injuries are a leading cause of disability and death in Cambodia. Economic development has long been associated with rapid increases in road traffic injuries and fatalities. Drink driving is of particular concern in Cambodia. In 2014, the percentage of fatal crashes involving alcohol rose to 17.5% (n = 381), representing a 34.9% (n = 253) increase from 2012. This study aims to illustrate current knowledge, attitudes and practices (KAP) around drinking and driving in three Cambodian provinces...
March 2017: Public Health
https://www.readbyqxmd.com/read/28286931/association-between-baseline-frailty-and-driving-status-over-time-a-secondary-analysis-of-the-national-health-and-aging-trends-study
#8
Elizabeth G Bond, Laura L Durbin, Jodi A Cisewski, Min Qian, Jack M Guralnik, Judith D Kasper, Thelma J Mielenz
BACKGROUND: Continued automobile driving is important for the wellbeing and independence of older adults. Frailty has been associated with a variety of negative health outcomes, but studies are lacking on the potential association between frailty and driving status. The present study uses data from The National Health and Aging Trends Study (NHATS) to assess if the presence of frailty is associated with being a current non-driver. METHODS: NHATS is a nationally representative cohort study of Medicare beneficiaries (aged ≥65) that have been followed since 2011...
December 2017: Injury Epidemiology
https://www.readbyqxmd.com/read/28286483/long-term-effects-pathophysiological-mechanisms-and-risk-factors-of-chemotherapy-induced-peripheral-neuropathies-a-comprehensive-literature-review
#9
REVIEW
Nicolas Kerckhove, Aurore Collin, Sakahlé Condé, Carine Chaleteix, Denis Pezet, David Balayssac
Neurotoxic anticancer drugs, such as platinum-based anticancer drugs, taxanes, vinca alkaloids, and proteasome/angiogenesis inhibitors are responsible for chemotherapy-induced peripheral neuropathy (CIPN). The health consequences of CIPN remain worrying as it is associated with several comorbidities and affects a specific population of patients already impacted by cancer, a strong driver for declines in older adults. The purpose of this review is to present a comprehensive overview of the long-term effects of CIPN in cancer patients and survivors...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28285641/effectiveness-of-essential-amino-acid-supplementation-in-stimulating-whole-body-net-protein-anabolism-is-comparable-between-copd-patients-and-healthy-older-adults
#10
Renate Jonker, Nicolaas Ep Deutz, Marcia L Erbland, Paula J Anderson, Mariëlle Pkj Engelen
BACKGROUND: The development of effective nutritional strategies in support of muscle growth for patients with chronic obstructive pulmonary disease (COPD) remains challenging. Dietary essential amino acids (EAAs) are the main driver of postprandial net protein anabolism. In agreement, EAA supplements in healthy older adults are more effective than supplements with the composition of complete proteins. In patients with COPD it is still unknown whether complete protein supplements can be substituted with only EAAs, and whether they are as effective as in healthy older adults...
April 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28277282/letting-in-vehicle-navigation-lead-the-way-older-drivers-perceptions-of-and-ability-to-follow-a-gps-navigation-system
#11
Arne Stinchcombe, Sylvain Gagnon, Matthew Kateb, Meredith Curtis, Michelle M Porter, Jan Polgar, Michel Bédard
In-vehicle navigation systems have the potential to simplify the driving task by reducing the drivers' need to engage in wayfinding, especially in unfamiliar environments. This study sought to characterize older drivers' overall assessment of using in-vehicle GPS technology as part of a research study and to explore whether the use of this technology has an impact on participants' driving behaviour. Forty-seven older drivers completed an on-road evaluation where directions were provided by an in-vehicle GPS navigation system and their behaviour was recorded using video technology...
October 27, 2016: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28264676/service-use-of-older-people-who-participate-in-primary-care-health-promotion-a-latent-class-analysis
#12
John A Ford, Kalpa Kharicha, Caroline S Clarke, Allan Clark, Steve Iliffe, Claire Goodman, Jill Manthorpe, Nick Steel, Kate Walters
BACKGROUND: Recruiting patients to health promotion programmes who will benefit is crucial to success. A key policy driver for health promotion in older people is to reduce health and social care use. Our aim was to describe service use among older people taking part in the Multi-dimensional Risk Appraisal for Older people primary care health promotion programme. METHODS: A random sample of 1 in 3 older people (≥65 years old) was invited to participate in the Multi-dimensional Risk Appraisal for Older people project across five general practices in London and Hertfordshire...
March 6, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28249237/the-influence-of-age-related-health-difficulties-and-attitudes-toward-driving-on-driving-self-regulation-in-the-baby-boomer-and-older-adult-generations
#13
Elizabeth G Conlon, Nicole Rahaley, Jessica Davis
Our study aimed to determine how age- and disease-related difficulties were associated with attitudes and beliefs about driving self-regulation in men and women in the baby boomer and older generations. Three hundred and ninety-nine men (n=204) and women (n=195) aged between 48 and 91 years participated in a cross-sectional study of Australian drivers. Demographic characteristics and measures of driving confidence, driving difficulty and driving self-regulation; perceptions of visual, physical and cognitive capacity; and attitudes and beliefs about driving were obtained...
February 26, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28239638/brain-amyloid-in-preclinical-alzheimer-s-disease-is-associated-with%C3%A2-increased-driving-risk
#14
Brian R Ott, Richard N Jones, Richard B Noto, Don C Yoo, Peter J Snyder, Justine N Bernier, David B Carr, Catherine M Roe
INTRODUCTION: Postmortem studies suggest that fibrillar brain amyloid places people at higher risk for hazardous driving in the preclinical stage of Alzheimer's disease (AD). METHODS: We administered driving questionnaires to 104 older drivers (19 AD, 24 mild cognitive impairment, and 61 cognitive normal) who had a recent (18)F-florbetapir positron emission tomography scan. We examined associations of amyloid standardized uptake value ratios with driving behaviors: traffic violations or accidents in the past 3 years...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28226253/modeling-single-vehicle-run-off-road-crash-severity-in-rural-areas-accounting-for-unobserved-heterogeneity-and-age-difference
#15
Linfeng Gong, Wei David Fan
This study investigates factors that significantly contribute to the severity of driver injuries resulting from single-vehicle run-off-road (SV ROR) crashes. A mixed logit model approach is employed to explore the potential unobserved heterogeneous effects associated with each age group: young (ages 16-24), middle-aged (ages 25-65), and older drivers (ages over 65). Likelihood ratio tests indicated that the development of separate injury severity models for each age group is statistically superior to estimating a single model using all data...
February 19, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28223244/frailty-and-sarcopenia-the-potential-role-of-an-aged-immune-system
#16
REVIEW
Daisy Wilson, Thomas Jackson, Elizabeth Sapey, Janet M Lord
Frailty is a common negative consequence of ageing. Sarcopenia, the syndrome of loss of muscle mass, quality and strength, is more common in older adults and has been considered a precursor syndrome or the physical manifestation of frailty. The pathophysiology of both syndromes is incompletely described with multiple causes, inter-relationships and complex pathways proposed. Age-associated changes to the immune system (both immunesenescence, the decline in immune function with ageing, and inflammageing, a state of chronic inflammation) have been suggested as contributors to sarcopenia and frailty but a direct causative role remains to be established...
February 20, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/28218593/video-feedback-intervention-to-enhance-the-safety-of-older-drivers-with-cognitive-impairment
#17
Brian R Ott, Jennifer D Davis, Kimberly Bixby
OBJECTIVE: To demonstrate that g-force technology can be used to help older adults with cognitive impairment improve their driving safety as part of an in-car video feedback intervention. METHOD: Unsafe driving events triggered g-forces leading to capture of video clips. The program included 3 mo of monitoring without intervention, 3 mo of intervention (weekly written progress reports, a DVD of unsafe driving events, and weekly telephone contacts), and 3 mo of postintervention monitoring...
March 2017: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/28198091/impact-of-chronic-kidney-disease-on-2-year-clinical-outcomes-in-patients-treated-with-6-month-or-24-month-dapt-duration-an-analysis-from-the-prodigy-trial
#18
Giuseppe Gargiulo, Andrea Santucci, Raffaele Piccolo, Anna Franzone, Sara Ariotti, Andrea Baldo, Giovanni Esposito, Aris Moschovitis, Stephan Windecker, Marco Valgimigli
OBJECTIVES: To assess whether moderate-to-severe CKD is a treatment modifier for benefit or harm in patients randomly allocated to 24-month versus 6-month DAPT. BACKGROUND: It is still unclear whether chronic kidney disease CKD should impact on the decision-making on optimal duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI). METHODS AND RESULTS: PRODIGY trial randomized 1970 all-comer patients at 24-month versus 6-month DAPT after PCI...
February 15, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28193794/alcohol-policies-and-alcohol-related-motor-vehicle-crash-fatalities-among-young-people-in-the-us
#19
Scott E Hadland, Ziming Xuan, Vishnudas Sarda, Jason Blanchette, Monica H Swahn, Timothy C Heeren, Robert B Voas, Timothy S Naimi
BACKGROUND: Motor vehicle crashes (MVCs) are a leading cause of death among young people in the United States. We examined the relationship between states' alcohol policy environments and alcohol-related MVC fatalities among children, adolescents, and young adults under the minimum legal drinking age of 21 years. METHODS: We used the Alcohol Policy Scale (APS), an assessment of 29 alcohol policies across 50 states and Washington, DC, developed with the assistance of an interdisciplinary Delphi panel...
March 2017: Pediatrics
https://www.readbyqxmd.com/read/28192260/risk-factors-and-independent-predictors-of-30-day-readmission-for-altered-mental-status-after-elective-spine-surgery-for-spine-deformity-a-single-institutional-study-of-1090-patients
#20
Aladine A Elsamadicy, Owoicho Adogwa, Gireesh B Reddy, Amanda Sergesketter, Hunter Warwick, Terrell Jones, Joseph Cheng, Carlos A Bagley, Isaac O Karikari
BACKGROUND: Altered Mental Status (AMS) has been associated with inferior surgical outcomes. The factors leading to AMS after spine surgery are unknown. The aim of this study is to determine the risk factors and independent predictors of 30-day readmission for AMS in spine deformity patients after undergoing elective spine surgery. METHODS: The medical records of 1090 adult (≥18 years old) spine deformity patients undergoing elective spine surgery at a major academic institution from 2005 to 2015 were reviewed...
February 9, 2017: World Neurosurgery
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