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https://www.readbyqxmd.com/read/28103394/measuring-patient-engagement-which-health-care-engagement-behaviors-are-important-to-patients
#1
Huey-Ming Tzeng, James Marcus Pierson
AIM(S): This study identified patient health care engagement behaviors that are important to community-dwelling adult patients living in the southern region of the USA. BACKGROUND: Patient engagement has been identified as a key driver for containing health care costs, but the public and health care professionals lack a scientific understanding of patient engagement. A valid tool is needed for prompting patients to discuss health activities with their health care providers and to obtain support...
January 19, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28102544/nursing-perceptions-of-patient-safety-climate-in-the-gaza-strip-palestine
#2
A Elsous, A Akbari Sari, Y AlJeesh, M Radwan
AIMS: This study was undertaken to assess the perception of nurses about patient safety culture and to test whether it is significantly affected by the nurses' position, age, experience and working hours. BACKGROUND: Patient safety has sparked the interest of healthcare mangers, yet there is limited knowledge about the current patient safety culture among nurses in the Gaza Strip. METHODS: This was a descriptive cross-sectional study, administering the Arabic Safety Attitude Questionnaire (Short Form 2006) to 210 nurses in four public general hospitals...
January 19, 2017: International Nursing Review
https://www.readbyqxmd.com/read/28099479/social-contact-structures-and-time-use-patterns-in-the-manicaland-province-of-zimbabwe
#3
Alessia Melegaro, Emanuele Del Fava, Piero Poletti, Stefano Merler, Constance Nyamukapa, John Williams, Simon Gregson, Piero Manfredi
BACKGROUND: Patterns of person-to-person contacts relevant for infectious diseases transmission are still poorly quantified in Sub-Saharan Africa (SSA), where socio-demographic structures and behavioral attitudes are expected to be different from those of more developed countries. METHODS AND FINDINGS: We conducted a diary-based survey on daily contacts and time-use of individuals of different ages in one rural and one peri-urban site of Manicaland, Zimbabwe. A total of 2,490 diaries were collected and used to derive age-structured contact matrices, to analyze time spent by individuals in different settings, and to identify the key determinants of individuals' mixing patterns...
2017: PloS One
https://www.readbyqxmd.com/read/28077784/identification-and-characterization-of-hpv-independent-cervical-cancers
#4
Carolyn E Banister, Changlong Liu, Lucia Pirisi, Kim E Creek, Phillip J Buckhaults
BACKGROUND: Human papillomavirus (HPV) initiates cervical cancer, and continuous expression of HPV oncogenes E6 and E7 is thought to be necessary to maintain malignant growth. Current therapies target proliferating cells, rather than specific pathways, and most experimental therapies specifically target E6/E7. We investigated the presence and expression of HPV in cervical cancer, to correlate HPV oncogene expression with clinical and molecular features of these tumors that may be relevant to new targeted therapies...
January 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28077179/scared-behind-the-wheel-what-impact-does-driving-anxiety-have-on-the-health-and-well-being-of-young-older-adults
#5
Megan E Hempel, Joanne E Taylor, Martin J Connolly, Fiona M Alpass, Christine V Stephens
BACKGROUND: Driving anxiety can range from driving reluctance to driving phobia, and 20% of young older adults experience mild driving anxiety, whereas 6% report moderate to severe driving anxiety. However, we do not know what impact driving anxiety has on health and well-being, especially among older drivers. This is problematic because there is a growing proportion of older adult drivers and a potential for driving anxiety to result in premature driving cessation that can impact on health and mortality...
January 12, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28069887/mandatory-physician-reporting-of-at-risk-drivers-the-older-driver-example
#6
Yll Agimi, Steven M Albert, Ada O Youk, Patricia I Documet, Claudia A Steiner
PURPOSE OF THE STUDY: In a number of states, physicians are mandated by state law to report at-risk drivers to licensing authorities. Often these patients are older adult drivers who may exhibit unsafe driving behaviors, have functional/cognitive impairments, or are diagnosed with conditions such as Alzheimer's disease and/or seizure disorders. The hypothesis that mandatory physician reporting laws reduce the rate of crash-related hospitalizations among older adult drivers was tested...
January 9, 2017: Gerontologist
https://www.readbyqxmd.com/read/28068485/obesity-in-low-and-middle-income-countries-burden-drivers-and-emerging-challenges
#7
Nicole D Ford, Shivani A Patel, K M Venkat Narayan
We have reviewed the distinctive features of excess weight, its causes, and related prevention and management efforts, as well as data gaps and recommendations for future research in low- and middle-income countries (LMICs). Obesity is rising in every region of the world, and no country has been successful at reversing the epidemic once it has begun. In LMICs, overweight is higher in women compared with men, in urban compared with rural settings, and in older compared with younger individuals; however, the urban-rural overweight differential is shrinking in many countries...
December 23, 2016: Annual Review of Public Health
https://www.readbyqxmd.com/read/28067895/the-nf1-gene-in-tumor-syndromes-and-melanoma
#8
Maija Kiuru, Klaus J Busam
Activation of the RAS/MAPK pathway is critical in melanoma. Melanoma can be grouped into four molecular subtypes based on their main genetic driver: BRAF-mutant, NRAS-mutant, NF1-mutant, and triple wild-type tumors. The NF1 protein, neurofibromin 1, negatively regulates RAS proteins through GTPase activity. Germline mutations in NF1 cause neurofibromatosis type I, a common genetic tumor syndrome caused by dysregulation of the RAS/MAPK pathway, ie, RASopathy. Melanomas with NF1 mutations typically occur on chronically sun-exposed skin or in older individuals, show a high mutation burden, and are wild-type for BRAF and NRAS...
January 9, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28063843/partial-differential-equation-techniques-for-analysing-animal-movement-a-comparison-of-different-methods
#9
Yi-Shan Wang, Jonathan R Potts
Recent advances in animal tracking have allowed us to uncover the drivers of movement in unprecedented detail. This has enabled modellers to construct ever more realistic models of animal movement, which aid in uncovering detailed patterns of space use in animal populations. Partial differential equations (PDEs) provide a popular tool for mathematically analysing such models. However, their construction often relies on simplifying assumptions which may greatly affect the model outcomes. Here, we analyse the effect of various PDE approximations on the analysis of some simple movement models, including a biased random walk, central-place foraging processes and movement in heterogeneous landscapes...
January 5, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28054571/factors-associated-with-awareness-treatment-and-control-of-hypertension-in-a-disadvantaged-rural-indian-population
#10
D Busingye, S Arabshahi, R G Evans, V K Srikanth, K Kartik, K Kalyanram, M A Riddell, X Zhu, O Suresh, A G Thrift
The aim of this study was to identify factors associated with awareness, treatment and control of hypertension in a rural setting in India. Following screening of the population, all individuals with hypertension (blood pressure (BP) ⩾140/90 mm Hg or taking antihypertensive medications) were invited to participate in this study. We measured BP, height, weight, skinfolds, waist and hip circumference, and administered a questionnaire to obtain information regarding socioeconomic and behavioural characteristics...
January 5, 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28054452/climate-female-traits-and-population-features-as-drivers-of-breeding-timing-in-mediterranean-red-deer-populations
#11
Marta Peláez, Alfonso San Miguel, Carlos Rodríguez-Vigal, Ramón Perea
Understanding the factors that lead to variation in the timing of breeding in widespread species such as red deer (Cervus elaphus L.) is crucial to predict possible responses of wild populations to different climate scenarios. Here, we sought to further understand the causes of inter-annual variation in the reproduction timing of female deer in Mediterranean environments. An integrative approach was used to identify the relative importance of individual, population and climate traits in the date of conception of free ranging deer, based on a dataset of 829 hinds culled during 12 years...
January 5, 2017: Integrative Zoology
https://www.readbyqxmd.com/read/28027320/genomic-analysis-of-uterine-lavage-fluid-detects-early-endometrial-cancers-and-reveals-a-prevalent-landscape-of-driver-mutations-in-women-without-histopathologic-evidence-of-cancer-a-prospective-cross-sectional-study
#12
Navya Nair, Olga Camacho-Vanegas, Dmitry Rykunov, Matthew Dashkoff, Sandra Catalina Camacho, Cassie A Schumacher, Jonathan C Irish, Timothy T Harkins, Elijah Freeman, Isaac Garcia, Elena Pereira, Sviatoslav Kendall, Rachel Belfer, Tamara Kalir, Robert Sebra, Boris Reva, Peter Dottino, John A Martignetti
BACKGROUND: Endometrial cancer is the most common gynecologic malignancy, and its incidence and associated mortality are increasing. Despite the immediate need to detect these cancers at an earlier stage, there is no effective screening methodology or protocol for endometrial cancer. The comprehensive, genomics-based analysis of endometrial cancer by The Cancer Genome Atlas (TCGA) revealed many of the molecular defects that define this cancer. Based on these cancer genome results, and in a prospective study, we hypothesized that the use of ultra-deep, targeted gene sequencing could detect somatic mutations in uterine lavage fluid obtained from women undergoing hysteroscopy as a means of molecular screening and diagnosis...
December 2016: PLoS Medicine
https://www.readbyqxmd.com/read/28025281/meta-analysis-of-driving-cessation-and-dementia-does-sex-matter
#13
Nicolette Baines, Bonnie Au, Mark J Rapoport, Gary Naglie, Mary C Tierney
OBJECTIVES: The number of drivers with dementia is expected to increase over the coming decades. Because dementia is associated with a higher risk of crashes, driving cessation becomes inevitable as the disease progresses, but many people with dementia resist stopping to drive. This meta-analysis examines whether there are sex differences in the prevalence and incidence of driving cessation among drivers with dementia and compares the pattern of sex differences in drivers with dementia to those without dementia...
December 26, 2016: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28005921/association-of-functional-impairments-and-co-morbid-conditions-with-driving-performance-among-cognitively-normal-older-adults
#14
David B Carr, Peggy P Barco, Ganesh M Babulal, Sarah H Stout, Anne M Johnson, Chengjie Xiong, John C Morris, Catherine M Roe
OBJECTIVES: To examine the relationship between key functional impairments, co-morbid conditions and driving performance in a sample of cognitively normal older adults. DESIGN: Prospective observational study. SETTING: The Knight Alzheimer's Disease Research Center, Washington University at St. Louis. PARTICIPANTS: Individuals with normal cognition, 64.9 to 88.2 years old (N = 129), with a valid driver's license, who were currently driving at least once per week, and who had participated in longitudinal studies at the Knight Alzheimer's Disease Research Center...
2016: PloS One
https://www.readbyqxmd.com/read/27991417/the-economic-burden-of-chronic-psychotic-disorders-in-ontario
#15
Claire de Oliveira, Joyce Cheng, Juergen Rehm, Paul Kurdyak
BACKGROUND: Chronic psychotic disorders are severe and disabling mental disorders associated with poor psychiatric and medical outcomes. These disorders are considered one of the most costly mental disorders due young age at onset and the need for intensive health care over the life course. AIMS OF THE STUDY: The purpose of this study was to estimate the direct health care costs of chronic psychotic disorders in Ontario in 2012 from the perspective of the third-party payer (i...
December 1, 2016: Journal of Mental Health Policy and Economics
https://www.readbyqxmd.com/read/27990264/creating-a-driving-profile-for-older-adults-using-gps-devices-and-naturalistic-driving-methodology
#16
Ganesh M Babulal, Cindy M Traub, Mollie Webb, Sarah H Stout, Aaron Addison, David B Carr, Brian R Ott, John C Morris, Catherine M Roe
Background/Objectives: Road tests and driving simulators are most commonly used in research studies and clinical evaluations of older drivers. We adapted an existing, commercial, off-the-shelf, in-vehicle device for naturalistic, longitudinal research to better understand daily driving behavior in older drivers. Design: The Azuga G2 Tracking Device (TM) was installed in each participant's vehicle, and we collected data over 5 months (speed, latitude/longitude) every 30-seconds when the vehicle was driven.  Setting: The Knight Alzheimer's Disease Research Center at Washington University School of Medicine...
2016: F1000Research
https://www.readbyqxmd.com/read/27984723/in%C3%A2-vivo-amelioration-of-age-associated-hallmarks-by-partial-reprogramming
#17
Alejandro Ocampo, Pradeep Reddy, Paloma Martinez-Redondo, Aida Platero-Luengo, Fumiyuki Hatanaka, Tomoaki Hishida, Mo Li, David Lam, Masakazu Kurita, Ergin Beyret, Toshikazu Araoka, Eric Vazquez-Ferrer, David Donoso, Jose Luis Roman, Jinna Xu, Concepcion Rodriguez Esteban, Gabriel Nuñez, Estrella Nuñez Delicado, Josep M Campistol, Isabel Guillen, Pedro Guillen, Juan Carlos Izpisua Belmonte
Aging is the major risk factor for many human diseases. In vitro studies have demonstrated that cellular reprogramming to pluripotency reverses cellular age, but alteration of the aging process through reprogramming has not been directly demonstrated in vivo. Here, we report that partial reprogramming by short-term cyclic expression of Oct4, Sox2, Klf4, and c-Myc (OSKM) ameliorates cellular and physiological hallmarks of aging and prolongs lifespan in a mouse model of premature aging. Similarly, expression of OSKM in vivo improves recovery from metabolic disease and muscle injury in older wild-type mice...
December 15, 2016: Cell
https://www.readbyqxmd.com/read/27943260/effects-of-a-safe-transportation-educational-program-for-older-drivers-on-driving-exposure-and-community-participation-a-randomized-controlled-trial
#18
Kristy Coxon, Anna Chevalier, Julie Brown, Elizabeth Clarke, Laurent Billot, Soufiane Boufous, Rebecca Ivers, Lisa Keay
OBJECTIVES: To ascertain whether a safe-transportation program can change driving exposure while maintaining community participation of older drivers. DESIGN: Randomized controlled trial. SETTING: Northwest Sydney. PARTICIPANTS: Drivers aged 75 and older (mean 80 ± 4) (n = 380). INTERVENTION: Intervention group participated in an individualized, one-on-one safe-transportation program adapted from the Knowledge Enhances Your Safety curriculum...
December 9, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27936362/prevalence-of-self-reported-prescription-drug-use-in-a-national-sample-of-u-s-drivers
#19
Tara Kelley-Baker, Geetha Waehrer, Robin A Pollini
OBJECTIVE: Drug-involved driving has become an increasing concern. Although the focus has been on illegal drugs, there is evidence that prescribed medications can impair driving ability. The purpose of this study was to determine the self-reported prevalence of prescription drug use, including medical and nonmedical use, among a nationally representative sample of drivers and to report related driver characteristics. METHOD: As part of the 2013-2014 National Roadside Survey, drivers from 60 sites were randomly recruited and asked to complete a survey on prescription drug use...
January 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/27920510/the-clock-in-the-box-a-brief-cognitive-screen-is-associated-with-failure-to-return-home-in-an-elderly-hospitalized-sample
#20
Colleen E Jackson, Laura J Grande, Kelly Doherty, Elizabeth Archambault, Brittany Kelly, Jane A Driver, William P Milberg, Regina McGlinchey, James L Rudolph
PURPOSE: Cognitive screening upon hospital admission can provide important information about the patient's ability to process information during the inpatient stay. The Clock-in-the-Box (CIB) is a rapidly administered cognitive screening measure which has been previously validated with cognitive screening and neuropsychological assessments. The purpose of this study is to demonstrate the predictive validity of the CIB for discharge location among a sample of older medical inpatients. PATIENTS AND METHODS: Hospitalized Veterans (N=218), aged 55 years and older, were recruited on the day after admission after they gave their consent...
2016: Clinical Interventions in Aging
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