keyword
https://read.qxmd.com/read/38514927/the-association-between-genetic-polymorphisms-of-matrix-metalloproteinases-and-knee-osteoarthritis-a-systematic-review-and-meta-analysis
#21
REVIEW
Xu Jiang, Qianqian Wang, Chao Wang, Yanzhuo Zhang, Zhenjie Wei, Zhimin Wu, Shunan Yu, Chengai Wu
AIM: To investigate the linkage of matrix metalloproteinase (MMP) gene polymorphisms with the pathogenesis of knee osteoarthritis (OA). METHODS: This meta-analysis study systematically retrieved relevant studies from PubMed, Embase, the Cochrane Central, Wanfang Data, CNKI, and SinoMed up to November 2020. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the association between MMP gene polymorphisms and OA. RESULTS: A total of nine case-control studies comprising 1719 knee OA patients and 1904 controls were included in this meta-analysis...
March 2024: International Journal of Rheumatic Diseases
https://read.qxmd.com/read/38513880/a-higher-platelet-dose-may-yield-better-clinical-outcomes-for-prp-in-the-treatment-of-knee-osteoarthritis-a-systematic-review
#22
REVIEW
William A Berrigan, Zach Bailowitz, Anna Park, Aakash Reddy, Ryan Liu, Drew Lansdown
PURPOSE: To determine if the platelet dose administered during a platelet-rich plasma (PRP) injection for knee osteoarthritis (OA) impacts clinical outcomes. METHODS: A systematic review was performed by searching PubMed, Cochrane Library, and Embase for randomized controlled trials with at least one study arm using PRP for knee OA. Only studies that provided a platelet count, concentration, or dose with a minimum of 6-month outcome scores were included. Studies in which the PRP group had statistically significant positive outcomes were separated from those without statistical significance...
March 19, 2024: Arthroscopy
https://read.qxmd.com/read/38513397/a-semi-supervised-multiview-mri-network-for-the-detection-of-knee-osteoarthritis
#23
JOURNAL ARTICLE
Mohamed Berrimi, Didier Hans, Rachid Jennane
Knee OsteoArthritis (OA) is a prevalent chronic condition, affecting a significant proportion of the global population. Detecting knee OA is crucial as the degeneration of the knee joint is irreversible. In this paper, we introduce a semi-supervised multi-view framework and a 3D CNN model for detecting knee OA using 3D Magnetic Resonance Imaging (MRI) scans. We introduce a semi-supervised learning approach combining labeled and unlabeled data to improve the performance and generalizability of the proposed model...
March 16, 2024: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://read.qxmd.com/read/38512989/lateral-unicompartmental-knee-arthroplasty-for-osteoarthritis-secondary-to-lateral-meniscectomy-high-functional-results-and-survivorship-and-low-osteoarthritis-progression-at-a-mean-10-years-of-follow-up
#24
JOURNAL ARTICLE
Matteo Marullo, Antonio Russo, Andrea Spreafico, Sergio Romagnoli
BACKGROUND: Meniscectomy, whether partial or total, is a common knee surgery, but it considerably increases the risk of knee osteoarthritis (OA). Lateral meniscectomy has more severe consequences than medial meniscectomy, leading to faster OA progression and worse clinical outcomes. Unicompartmental knee arthroplasty (UKA) is a suitable treatment option for lateral OA and has demonstrated better outcomes than total knee arthroplasty (TKA). The aims of this study were to evaluate the clinical and functional results, OA progression in the medial compartment, and implant survivorship following lateral UKA in patients with OA secondary to lateral meniscectomy and to compare these outcomes with those of patients who underwent lateral UKA for primary lateral OA...
March 21, 2024: Journal of Bone and Joint Surgery. American Volume
https://read.qxmd.com/read/38511070/the-effects-of-exercise-and-intra-articular-injections-versus-exercise-alone-for-the-treatment-of-knee-osteoarthritis-a-scoping-review-of-the-evidence
#25
REVIEW
Sydney C Liles, Bradley Bley, Daniel K White
OBJECTIVE: Current treatment for knee Osteoarthritis (OA) includes exercise and intra-articular injections with corticosteroid (CS), hyaluronic acid (HA), etc., which address OA-related pain and functional limitation. While these interventions can be given together, little is known about the efficacy of a multi-modal approach. The purpose of this scoping review is to examine studies that compare combining exercise and intra-articular knee injections to exercise alone for the management of knee OA...
June 2024: Osteoarthritis and cartilage open
https://read.qxmd.com/read/38510323/microfragmented-adipose-tissue-is-equivalent-to-platelet-rich-plasma-for-knee-osteoarthritis-at-12-months-posttreatment-a-randomized-controlled-trial
#26
JOURNAL ARTICLE
Michael Baria, Tyler Barker, Sushmitha Durgam, Angela Pedroza, David Flanigan, Liuqing Jia, Christopher Kaeding, Robert Magnussen
BACKGROUND: Platelet-rich plasma (PRP) is an effective treatment for knee osteoarthritis (OA). Microfragmented adipose tissue (MFAT) is another orthobiologic that holds promise, but data supporting its use are limited. Previous studies showed that MFAT created using the Lipogems device was equivalent to PRP created via noncommercial laboratory-based processes. PURPOSE: To perform a comparison of commercially available MFAT and PRP systems for treatment of knee OA...
March 2024: Orthopaedic Journal of Sports Medicine
https://read.qxmd.com/read/38509602/targeting-stat6-mediated-synovial-macrophage-activation-improves-pain-in-experimental-knee-osteoarthritis
#27
JOURNAL ARTICLE
Garth Blackler, Yue Lai-Zhao, Joseph Klapak, Holly T Philpott, Kyle K Pitchers, Andrew R Maher, Benoit Fiset, Logan A Walsh, Elizabeth R Gillies, C Thomas Appleton
BACKGROUND: Pain from osteoarthritis (OA) is one of the top causes of disability worldwide, but effective treatment is lacking. Nociceptive factors are released by activated synovial macrophages in OA, but depletion of synovial macrophages paradoxically worsens inflammation and tissue damage in previous studies. Rather than depleting macrophages, we hypothesized that inhibiting macrophage activation may improve pain without increasing tissue damage. We aimed to identify key mechanisms mediating synovial macrophage activation and test the role of STAT signaling in macrophages on pain outcomes in experimental knee OA...
March 20, 2024: Arthritis Research & Therapy
https://read.qxmd.com/read/38508289/arthroscopic-debridement-of-mild-and-moderate-knee-osteoarthritis-results-in-clinical-improvement-at-short-term-follow-up-a-systematic-review
#28
REVIEW
Eric J Cotter, Alexander C Weissman, Allen A Yazdi, Sarah A Muth, Brian J Cole
PURPOSE: To report the clinical outcomes of arthroscopic debridement for the treatment of Kellgren Lawrence (KL) grades I and II (mild), and III (moderate) knee osteoarthritis (OA) at minimum 1-year follow-up. METHODS: A systematic review of primary literature was performed in concordance with PRISMA guidelines using the Medline, Embase, and Cochrane databases for studies regarding arthroscopic debridement/chondroplasty for management of knee OA at minimum 1-year follow-up...
March 18, 2024: Arthroscopy
https://read.qxmd.com/read/38506121/deformity-in-valgus-knee-malalignment-is-not-only-in-the-femur-but-also-in-tibia-or-both-based-on-demographic-and-morphological-analysis-before-and-after-knee-osteotomies
#29
JOURNAL ARTICLE
Jae-Sung An, Christophe Jacquet, Glauco Loddo, Ahmed Mabrouk, Hideyuki Koga, Jean-Noël Argenson, Matthieu Ollivier
PURPOSE: This study aims to identify the demographic and morphological features of valgus knee deformity with unilateral osteoarthritic knee in the coronal plane. A secondary aim was to identify the distinct phenotypes of valgus knees in Hirschmann's phenotype and the coronal plane alignment of the knee (CPAK) classifications before and after a knee osteotomy (KO). METHODS: A total of 107 patients (57 female and 50 male) with a mean age of 42.4 ± 17...
March 20, 2024: Knee Surgery, Sports Traumatology, Arthroscopy
https://read.qxmd.com/read/38505969/endoplasmic-reticulum-stress-related-protein-grp78-and-chop-levels-in-synovial-fluid-correlate-with-disease-progression-of-primary-knee-osteoarthritis-a-cross-sectional-study
#30
JOURNAL ARTICLE
Dan-Dan Liu, Yuan-Chuang Zhao, Hai-Hong Li, Lian-Jun Yin, Jun-Qi Chen, Gang Liu
BACKGROUND: Endoplasmic reticulum (ER) stress has been shown to play an important role in osteoarthritis (OA). OBJECTIVE: This study was aimed at assessing the relationship of endoplasmic reticulum (ER) stress-related glucose-regulated protein 78 (GRP78) and CCAAT/enhancer-binding protein homologous protein (CHOP) concentrations in the serum/synovial fluid (SF) with disease severity of primary knee osteoarthritis (pkOA). METHODS: Patients with pkOA together with healthy individuals were consecutively recruited from our hospital...
March 2024: Journal of Applied Biomedicine
https://read.qxmd.com/read/38504181/rna-binding-proteins-potentially-regulate-the-alternative-splicing-of-apoptotic-genes-during-knee-osteoarthritis-progression
#31
JOURNAL ARTICLE
Zheng Zhang, Limei Dong, Hai Tao, Yusong Dong, Wei Xiang, Fenghua Tao, Yingchun Zhao
BACKGROUND: Alternative splicing (AS) is a principal mode of genetic regulation and one of the most widely used mechanisms to generate structurally and functionally distinct mRNA and protein variants. Dysregulation of AS may result in aberrant transcription and protein products, leading to the emergence of human diseases. Although considered important for regulating gene expression, genome-wide AS dysregulation, underlying mechanisms, and clinical relevance in knee osteoarthritis (OA) remain unelucidated...
March 19, 2024: BMC Genomics
https://read.qxmd.com/read/38500250/structure-guided-discovery-of-potent-and-selective-clk2-inhibitors-for-the-treatment-of-knee-osteoarthritis
#32
JOURNAL ARTICLE
Yongqiang Sun, Tianxing Hu, Mengdi Zhang, Jiaxing Song, Zhen Qin, Mai Liu, Jinliang Ji, Zhiyu Li, Zhixia Qiu, Jinlei Bian
Osteoarthritis is the most common joint disorder. However, there are no disease-modifying drugs approved for OA treatment. CDC2-like kinase 2 (CLK2) could modulate Wnt signaling via alternative splicing of Wnt target genes and further affect bone differentiation, chondrocyte function, and inflammation, making CLK2 an attractive target for OA therapy. In this study, we designed and synthesized a series of highly potent CLK2 inhibitors based on Indazole 1 . Among them, compound LQ23 showed more elevated inhibitory activity against CLK2 than the lead compound (IC50 , 1...
March 18, 2024: Journal of Medicinal Chemistry
https://read.qxmd.com/read/38500177/glaucocalyxin-a-delays-the-progression-of-oa-by-inhibiting-nf-%C3%AE%C2%BAb-and-mapk-signaling-pathways
#33
JOURNAL ARTICLE
Xin Hong, Xuqiang Liu, Bo Li, Shoujie Shi, Kai Xiao, Tiantian Xu, Yaoyang Nie, Min Dai, Meisong Zhu
BACKGROUND: Osteoarthritis (OA) is a common degenerative joint condition marked by inflammation and cartilage breakdown. Currently, there is a dearth of treatment medications that can clearly slow the course of OA. Glaucocalyxin A (GLA) is a diterpene chemical identified and extracted from Rabdosia japonica with antithrombotic, anticoagulant, anti-tumor, anti-inflammatory, anti-oxidant, and other pharmacological properties. Previous research has linked inflammation to abnormalities in the homeostasis of the extracellular matrix (ECM)...
March 18, 2024: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/38499500/pannexin-3-deletion-in-mice-results-in-knee-osteoarthritis-and-intervertebral-disc-degeneration-after-forced-treadmill-running
#34
JOURNAL ARTICLE
Brent Wakefield, Justin Tang, Jeffrey L Hutchinson, Rehanna Kanji, Courtney Brooks, Matthew W Grol, Cheryle A Séguin, Silvia Penuela, Frank Beier
Pannexin 3 (Panx3) is a glycoprotein that forms mechanosensitive channels expressed in chondrocytes and annulus fibrosus cells of the intervertebral disc (IVD). Evidence suggests Panx3 plays contrasting roles in traumatic versus aging osteoarthritis (OA) and intervertebral disc degeneration (IDD). However, whether its deletion influences the response of joint tissue to forced use is unknown. The purpose of this study was to determine if Panx3 deletion in mice causes increased knee joint OA and IDD after forced treadmill running...
March 18, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/38498142/long-term-efficacy-following-intra-articular-injection-of-carboxymethyl-chitosan-a-new-product-class-for-knee-osteoarthritis-results-from-an-observational-study-in-germany
#35
JOURNAL ARTICLE
Nils A Lynen, Christoph Eichhorn, Nicolas Portelange, Mickaël Chausson, Wim Weyenberg
INTRODUCTION: Evaluate the real-world efficacy of a single intra-articular injection of carboxymethyl-chitosan (CM-chitosan), a new product class for knee osteoarthritis (OA). METHODS: This post-marketing study included adult patients with knee OA, who received a single injection of 60 mg CM-chitosan (currently marketed as KioMedinevs one) according to the instructions for use. Follow-up was performed at weeks 1, 12, 24, and 36. Efficacy was evaluated using a Visual Analog Scale (VAS) score for pain, the Knee injury and Osteoarthritis Outcome Score (KOOS), Patient's Global Assessment (PGA), and overall patient satisfaction...
March 18, 2024: Rheumatology and Therapy
https://read.qxmd.com/read/38496031/functional-meniscus-reconstruction-with-biological-and-biomechanical-heterogeneities-through-topological-self-induction-of-stem-cells
#36
JOURNAL ARTICLE
Mingze Du, Kangze Liu, Huinan Lai, Jin Qian, Liya Ai, Jiying Zhang, Jun Yin, Dong Jiang
Meniscus injury is one of the most common sports injuries within the knee joint, which is also a crucial pathogenic factor for osteoarthritis (OA). The current meniscus substitution products are far from able to restore meniscal biofunctions due to the inability to reconstruct the gradient heterogeneity of natural meniscus from biological and biomechanical perspectives. Here, inspired by the topology self-induced effect and native meniscus microstructure, we present an innovative tissue-engineered meniscus (TEM) with a unique gradient-sized diamond-pored microstructure (GSDP-TEM) through dual-stage temperature control 3D-printing system based on the mechanical/biocompatibility compatible high Mw poly(ε-caprolactone) (PCL)...
June 2024: Bioactive Materials
https://read.qxmd.com/read/38495348/prognostic-value-of-b-score-for-predicting-joint-replacement-in-the-context-of-osteoarthritis-phenotypes-data-from-the-osteoarthritis-initiative
#37
JOURNAL ARTICLE
F Saxer, D Demanse, A Brett, D Laurent, L Mindeholm, P G Conaghan, M Schieker
OBJECTIVE: Developing new therapies for knee osteoarthritis (KOA) requires improved prediction of disease progression. This study evaluated the prognostic value of clinical clusters and machine-learning derived quantitative 3D bone shape B-score for predicting total and partial knee replacement (KR). DESIGN: This retrospective study used longitudinal data from the Osteoarthritis Initiative. A previous study used patients' clinical profiles to delineate phenotypic clusters...
June 2024: Osteoarthritis and cartilage open
https://read.qxmd.com/read/38493143/low-intensity-pulsed-ultrasound-delays-the-progression-of-osteoarthritis-by-regulating-the-yap-ripk1-nf-%C3%AE%C2%BAb-axis-and-influencing-autophagy
#38
JOURNAL ARTICLE
Chunran Pan, Fan Lu, Xiaoxia Hao, Xiaofeng Deng, Jiawei Liu, Kai Sun, Wenjie Hou, Xingru Shang, Ruimin Chi, Fengjing Guo, Tao Xu
BACKGROUND: Osteoarthritis (OA) is a degenerative disease characterized by chronic inflammation of the joint. As the disease progresses, patients will gradually develop symptoms such as pain, physical limitations and even disability. The risk factors for OA include genetics, gender, trauma, obesity, and age. Unfortunately, due to limited understanding of its pathological mechanism, there are currently no effective drugs or treatments to suspend the progression of osteoarthritis. In recent years, some studies found that low-intensity pulsed ultrasound (LIPUS) may have a positive effect on osteoarthritis...
March 16, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38492047/the-effect-of-balance-exercises-on-central-sensitization-in-patients-with-knee-osteoarthritis
#39
JOURNAL ARTICLE
Emre Tirasci, Tunay Sarpel, Ilke Coskun Benlidayi, Volkan Deniz
The aim of this study was to evaluate the effectiveness of balance exercises on functional status, pain, balance, and central sensitization in patients with knee osteoarthritis (OA). Patients diagnosed with bilateral Kellgren-Lawrence grade ≥ 2 primary knee OA and associated central sensitization were included in the study. Patients were randomized into two groups. Both groups were provided with verbal and written information on knee OA. In addition, the intervention group received a supervised balance exercise program for 6 weeks, 3 days a week on alternating days...
March 16, 2024: Rheumatology International
https://read.qxmd.com/read/38491834/estimating-the-minimal-clinically-important-difference-on-the-visual-analogue-scale-for-carpometacarpal-thumb-joint-osteoarthritis
#40
JOURNAL ARTICLE
Oluwatobi R Olaiya, Beraki Abraha, Lucas Gallo, Caroline Hircock, Minh Huynh, Matthew McRae
BACKGROUND: The minimal clinically important difference (MCID) is the smallest perceived treatment effect that patients deem clinically significant. There is currently no agreement on an appropriate MCID for the pain visual analogue scale (VAS) in the context of thumb osteoarthritis (OA). METHODS: We approximated MCIDs using a distribution-based approach that pooled standard deviations (SDs) associated with baseline mean values of the pain VAS (0-100 mm). We extracted the data from randomized controlled trials (RCTs) included in a systematic review of adults with long-term OA of the thumb...
March 16, 2024: Hand: Official Journal of the American Association for Hand Surgery
keyword
keyword
52862
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.