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https://www.readbyqxmd.com/read/28934396/evaluation-of-shared-genetic-aetiology-between-osteoarthritis-and-bone-mineral-density-identifies-smad3-as-a-novel-osteoarthritis-risk-locus
#1
Sophie Hackinger, Katerina Trajanoska, Unnur Styrkarsdottir, Eleni Zengini, Julia Steinberg, Graham R S Ritchie, Konstantinos Hatzikotoulas, Arthur Gilly, Evangelos Evangelou, John P Kemp, David Evans, Thorvaldur Ingvarsson, Helgi Jonsson, Unnur Thorsteinsdottir, Kari Stefansson, Andrew W McCaskie, Roger A Brooks, Jeremy M Wilkinson, Fernando Rivadeneira, Eleftheria Zeggini
Osteoarthritis (OA) is a common complex disease with high public health burden and no curative therapy. High bone mineral density (BMD) is associated with an increased risk of developing OA, suggesting a shared underlying biology. Here, we performed the first systematic overlap analysis of OA and BMD on a genome wide scale. We used summary statistics from the GEFOS consortium for lumbar spine (n = 31,800) and femoral neck (n = 32,961) BMD, and from the arcOGEN consortium for three OA phenotypes (hip, ncases=3,498; knee, ncases=3,266; hip and/or knee, ncases=7,410; ncontrols=11,009)...
October 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28933742/vitamin-d-supplementation-improves-quality-of-life-and-physical-performance-in-osteoarthritis-patients
#2
Pacharee Manoy, Pongsak Yuktanandana, Aree Tanavalee, Wilai Anomasiri, Srihatach Ngarmukos, Thanathep Tanpowpong, Sittisak Honsawek
(1) Background: Lower levels of serum 25-hydroxyvitamin D (25(OH)D) are common in osteoarthritis (OA) patients. However, the effect of vitamin D supplementation on muscle strength and physical performance remains unclear. This study will investigate the effects of vitamin D₂ supplementation on muscle strength and physical performance in knee OA patients; (2) Methods: One hundred and seventy-five primary knee OA patients with low levels of serum 25(OH)D (<30 ng/mL) received 40,000 IU vitamin D₂ (ergocalciferol) per week for six months...
July 26, 2017: Nutrients
https://www.readbyqxmd.com/read/28932293/intra-articular-hyaluronic-acid-in-the-treatment-of-knee-osteoarthritis-a-canadian-evidence-based-perspective
#3
REVIEW
Mohit Bhandari, Raveendhara R Bannuru, Eric M Babins, Johanne Martel-Pelletier, Moin Khan, Jean-Pierre Raynauld, Renata Frankovich, Deanna Mcleod, Tahira Devji, Mark Phillips, Emil H Schemitsch, Jean-Pierre Pelletier
Osteoarthritis (OA) is a chronic condition characterized by a loss of joint cartilage and is a major cause of disability in Canada, with an estimated CN$195 billion annual cost. Knee OA leads to persistent pain and loss of function, and treatment goals primarily focus on symptom relief and retention of function. Intra-articular hyaluronic acid (IAHA) has therapeutic benefits, and numerous recently published meta-analyses (MAs) and commentaries have highlighted new evidence on the role of IAHA therapy for knee OA...
September 2017: Therapeutic Advances in Musculoskeletal Disease
https://www.readbyqxmd.com/read/28932004/effects-of-pulsed-therapeutic-ultrasound-on-the-treatment-of-people-with-knee-osteoarthritis
#4
Eliana-Isabel Rodríguez-Grande, Jose-Luis Osma-Rueda, Yannely Serrano-Villar, Carolina Ramírez
[Purpose] The aim was to evaluate the effect of therapeutic ultrasound on the pain, joint mobility, muscle strength, physical function, and quality of life of people with knee OA. [Subjects and Methods] One-site, one-arm, before-after study that included people with Grade II or III tibiofemoral osteoarthritis. Ten therapeutic ultrasound sessions (duty cycle=20%, ERA=10 cm(2), BNR=6:1, SATP=2.2 W/cm(2), SATA=0.44 W/cm(2), frequency=1 MHz, time=4 minutes) were applied. Assessments of primary outcome variables: pain intensity and function, and secondary variables: joint mobility, muscle strength and quality of life, were performed at onset and end of therapy; an additional intermediate evaluation was included for the primary variables...
September 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28929915/is-synovitis-detected-on-non-contrast-enhanced-magnetic-resonance-imaging-associated-with-serum-biomarkers-and-clinical-signs-of-effusion-data-from-the-osteoarthritis-initiative
#5
L A Deveza, V B Kraus, J E Collins, A Guermazi, F W Roemer, M C Nevitt, D J Hunter
OBJECTIVES: To determine the relationship between synovitis detected on non-contrast-enhanced (non-CE) magnetic resonance imaging (MRI), biochemical markers of inflammation, and clinical assessment of effusion in people with knee osteoarthritis (OA). METHOD: We examined data from the OA Biomarkers Consortium within the Osteoarthritis Initiative (n = 600). Non-CE MRIs were semi-quantitatively scored (grades 0-3) for severity of Hoffa synovitis and effusion synovitis...
September 20, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28929165/proprioception-mediates-the-association-between-systemic-inflammation-and-muscle-weakness-in-patients-with-knee-osteoarthritis-results-from-the-amsterdam-osteoarthritis-cohort
#6
Tomasz Cudejko, Martin van der Esch, Marike van der Leeden, Jasmijn Holla, Leo D Roorda, Willem Lems, Joost Dekker
OBJECTIVES: To determine whether systemic inflammation is associated with poor proprioception; to confirm that systemic inflammation is associated with muscle weakness; and to determine whether poor proprioception mediates the association between systemic inflammation and muscle weakness in knee osteoarthritis. DESIGN: Cross-sectional study. SUBJECTS: A total of 689 participants with knee osteoarthritis from the Amsterdam Osteoarthritis (AMS-OA) cohort...
September 20, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28928664/yougui-pills-attenuate-cartilage-degeneration-via-activation-of-tgf-%C3%AE-smad-signaling-in-chondrocyte-of-osteoarthritic-mouse-model
#7
Lei Zhang, Ping-Er Wang, Jun Ying, Xing Jin, Cheng Luo, Taotao Xu, Shibing Xu, Rui Dong, Luwei Xiao, Peijian Tong, Hongting Jin
Yougui pills (YGPs) have been used for centuries in the treatment of Chinese patients with Kidney-Yang Deficiency Syndrome. Despite the fact that the efficiency of YGPs on treating osteoarthritis has been verified in clinic, the underlying mechanisms are not totally understood. The present study observes the therapeutic role of YGPs and mechanisms underlying its chondroprotective action in osteoarthritic cartilage. To evaluate the chondroprotective effects of YGPs, we examined the impact of orally administered YGPs in a model of destabilization of the medial meniscus (DMM)...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28927387/development-of-the-treatment-beliefs-in-knee-and-hip-osteoarthritis-toa-questionnaire
#8
Ellen M H Selten, Johanna E Vriezekolk, Henk J Schers, Marc W Nijhof, Willemijn H van der Laan, Roelien G van der Meulen-Dilling, Rinie Geenen, Cornelia H M van den Ende
BACKGROUND: Use of conservative treatment modalities in osteoarthritis (OA) is suboptimal, which appears to be partly due to patients' beliefs about treatments. The aim of this study was to develop a research instrument assessing patients' beliefs about various treatment modalities of hip and knee OA: the 'Treatment beliefs in OA (TOA) questionnaire'. METHODS: The item pool that was retrieved from interviews with patients and healthcare providers comprised beliefs regarding five treatment modalities: physical activity, pain medication, physiotherapy, injections and arthroplasty...
September 19, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28926466/barriers-impeding-the-use-of-non-pharmacological-non-surgical-care-in-hip-and-knee-osteoarthritis-the-views-of-general-practitioners-physical-therapists-and-medical-specialists
#9
Ellen M H Selten, Johanna E Vriezekolk, Marc W Nijhof, Henk J Schers, Roelien G van der Meulen-Dilling, Willemijn H van der Laan, Rinie Geenen, Cornelia H M van den Ende
BACKGROUND: Non-pharmacological, non-surgical treatment modalities are underused in the management of knee and hip osteoarthritis (OA). One possible explanation for this could be healthcare providers' opinions about these treatment modalities. The objective of this qualitative study was to identify healthcare providers' views on non-pharmacological, non-surgical care for OA. METHODS: Semi-structured in-depth interviews with 24 healthcare providers (rheumatologists, orthopedic surgeons, physical therapists and general practitioners) were held...
September 19, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28921609/biomarkers-for-equine-joint-injury-and-osteoarthritis
#10
REVIEW
C Wayne McIlwraith, Christopher E Kawcak, David D Frisbie, Christopher B Little, Peter D Clegg, Mandy J Peffers, Morten A Karsdal, Stina Ekman, Sheila Laverty, Richard A Slayden, Linda J Sandell, L Stefan Lohmander, Virginia B Kraus
We report the results of a symposium aimed at identifying validated biomarkers that can be used to complement clinical observations for diagnosis and prognosis of joint injury leading to equine osteoarthritis (OA). Biomarkers might also predict pre-fracture change that could lead to catastrophic bone failure in equine athletes. The workshop was attended by leading scientists in the fields of equine and human musculoskeletal biomarkers to enable cross-disciplinary exchange and improve knowledge in both. Detailed proceedings with strategic planning was written, added to, edited and referenced to develop this manuscript...
September 16, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28921415/comparing-the-safety-and-efficacy-of-celecoxib-for-the-treatment-of-osteoarthritis-in-asian-and-non-asian-populations-an-analysis-of-data-from-two-randomized-double-blind-placebo-controlled-active-comparator-trials
#11
Andri Lubis, Wei Wang, Graça Lima, Rana Fayyad, Chris Walker
INTRODUCTION: Celecoxib is an effective treatment for pain associated with osteoarthritis. There are differences in patient demographics among ethnic groups, with Asian populations typically smaller in body size. As a consequence, there may be a perception that celecoxib is less effective, or has poorer tolerability in Asian patients. METHODS: This analysis compares data from two multicenter, randomized, double-blind, placebo-controlled, active-comparator trials of celecoxib for the treatment of osteoarthritis of the knee: one study in Asian patients and the other in a mixed population comprised mostly of non-Asian patients (from which Asian patients were excluded for this analysis)...
September 18, 2017: Pain and Therapy
https://www.readbyqxmd.com/read/28920170/meniscal-extrusion-seen-on-ultrasonography-affects-the-development-of-radiographic-knee-osteoarthritis-a-3-year-prospective-cohort-study
#12
Daisuke Chiba, Shugo Maeda, Eiji Sasaki, Seiya Ota, Shigeyuki Nakaji, Eiichi Tsuda, Yasuyuki Ishibashi
The objective of this study is to determine whether meniscal extrusion (ME) of the medial meniscus on ultrasonography affects knee osteoarthritis (KOA) progression during 3-year follow-up. Two hundred seventy volunteers (70 men, 200 women; mean age 60.5 years) participated. Weight-bearing radiographs were evaluated. All subjects had medial radiographic KOA (Kellgren-Lawrence grade [KLG], ≥ 2) in at least one knee at baseline (BL). KLG 2 was defined as moderate KOA (MKOA); KLG 3 and 4 were defined as severe KOA (SKOA)...
September 17, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28919498/accelerated-return-to-sport-after-acl-reconstruction-and-early-knee-osteoarthritis-features-at-1-year-an-exploratory-study
#13
Adam G Culvenor, Brooke E Patterson, Ali Guermazi, Hayden G Morris, Timothy S Whitehead, Kay M Crossley
BACKGROUND: A timely return to competitive sport is a primary goal of anterior cruciate ligament reconstruction (ACLR). It is not known if an accelerated return-to-sport increases the risk of early-onset knee osteoarthritis (KOA). OBJECTIVE: To determine whether an accelerated return-to-sport post-ACLR (i.e., <10 months) is associated with increased odds of early KOA features on MRI 1-year post-surgery, and to evaluate the relationship between an accelerated return-to-sport and early KOA features stratified by type of ACL injury (isolated or concurrent chondral/meniscal injury) and lower-limb function (good or poor)...
September 14, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28918594/the-association-of-knee-structural-pathology-with-pain-at-the-knee-is-modified-by-pain-at-other-sites-in-those-with-knee-osteoarthritis
#14
Feng Pan, Jing Tian, Dawn Aitken, Flavia Cicuttini, Tania Winzenberg, Graeme Jones
The objective of this study was to investigate the associations of knee structural abnormalities with different patterns of pain. A total of 891 participants (average age 63 years; range 50 to 80 years) participated in this study. Presence of pain at the neck, back, hands, shoulders, hips, knees, and feet was assessed by questionnaire. Participants were categorized as having no pain at any site (no pain), pain only at the knee (KP), pain at other sites but not the knee (OP), and pain at the knee and other sites (KOP)...
September 16, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28917712/toward-classification-criteria-for-early-osteoarthritis-of-the-knee
#15
F P Luyten, S Bierma-Zeinstra, F Dell'Accio, V B Kraus, K Nakata, I Sekiya, N K Arden, L S Lohmander
OBJECTIVE: To propose draft classification criteria for early stage osteoarthritis (OA) of the knee for use in a primary care setting. METHODS: A group of basic scientists, physician-scientists, rheumatologists, orthopedic surgeons, and physiotherapists in a workshop setting discussed potential classification criteria for early osteoarthritis of the knee. The workshop was divided into sessions around relevant topics with short state of the art presentations followed by breakout sessions, consensus discussions, and consolidation into a consensus document...
August 9, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28917083/effects-of-single-or-combined-administration-of-salmon-calcitonin-and-omega-3-fatty-acids-versus-diclofenac-sodium-in-sodium-monoiodoacetate-induced-knee-osteoarthritis-in-male-wistar-rats
#16
Wale J Adeyemi, Luqman A Olayaki
BACKGROUND: There is a continuous search for a better therapy in osteoarthritis (OA) management. Therefore, this study investigated the effects of salmon calcitonin (Sct) and/or omega-3 fatty acids (N-3) relative to diclofenac sodium (DF) in induced knee osteoarthritic male Wistar rats. METHODS: The 40 rats that were used in this study were divided into 8 groups (n=5 rats), viz: Normal control; OA control; OA+N-3; OA+Low dose of Sct (Sct.Lw); OA+High dose of Sct (Sct...
September 16, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28916728/association-between-tlr-9-gene-rs187084-polymorphism-and-knee-osteoarthritis-in-a-chinese-population
#17
Mingfeng Zheng, Shiyuan Shi, Qi Zheng, Yifan Wang, Xiaozhang Ying, Yanghui Jin
Osteoarthritis (OA) is a complex disease that is induced by many genetic risk variants and other factors. To examine the role of toll-like receptor 9 (TLR-9) in OA patients, we conducted a case-control study involving 215 knee OA (KOA) patients and 215 controls in a Chinese population. Genotyping with a custom-by-design 48-Plex single nucleotide polymorphism Scan™ Kit showed the TLR-9 gene rs187084 polymorphism was associated with an increased risk of KOA. Stratification analyses further validated this finding among old people (age ≥ 55y)...
September 15, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28916551/genetic-determinants-of-radiographic-knee-osteoarthritis-in-african-americans
#18
Youfang Liu, Michelle S Yau, Laura M Yerges-Armstrong, David J Duggan, Jordan B Renner, Marc C Hochberg, Braxton D Mitchell, Rebecca D Jackson, Joanne M Jordan
OBJECTIVE: The etiology of knee osteoarthritis (OA), the most common form of arthritis, is complex and may differ by race or ethnicity. In recent years, genetic studies have identified many genetic variants associated with OA, but nearly all the studies were conducted in European whites and Asian Americans. Few studies have focused on the genetics of knee OA in African Americans. METHODS: We performed a genome-wide association study of radiographic knee OA in 1217 African Americans from 2 North American cohort studies: 590 subjects from the Johnston County Osteoarthritis Project and 627 subjects from the Osteoarthritis Initiative...
September 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28906016/cxcl10-is-upregulated-in-synovium-and-cartilage-following-articular-fracture
#19
Bridgette D Furman, Collin L Kent, Janet L Huebner, Virginia B Kraus, Amy L McNulty, Farshid Guilak, Steven A Olson
The objective of this study was to investigate the expression of the chemokine CXCL10 and its role in joint tissues following articular fracture. We hypothesized that CXCL10 is upregulated following articular fracture and contributes to cartilage degradation associated with post-traumatic arthritis (PTA). To evaluate CXCL10 expression following articular fracture, gene expression was quantified in synovial tissue from knee joints of C57BL/6 mice that develop PTA following articular fracture, and MRL/MpJ mice that are protected from PTA...
September 14, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28905144/knee-osteoarthritis-and-associated-cardio-metabolic-clusters-in-a-tertiary-hospital-in-nigeria
#20
Abubakar Yerima, Olufemi Adelowo
Osteoarthritis (OA) of the knee is the most common type of arthritis all over the world. Obesity is the strongest modifiable risk factor and causes OA through a combination metabolic factors and mechanical loading. This study aimed to determine the frequency of metabolic syndrome (Mets) among patients with knee OA and its relationship with pain and functional status. This was a descriptive hospital-based cross-sectional study involving patients with knee OA. Pain was measured using a 0-10 numeric rating visual analog scale (VAS)...
September 13, 2017: Clinical Rheumatology
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