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Oesophageal atresia

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https://www.readbyqxmd.com/read/27894760/oesophageal-atresia-with-no-distal-tracheoesophageal-fistula-management-and-outcomes-from-a-population-based-cohort
#1
Anna-May Long, Athanasios Tyraskis, Benjamin Allin, David M Burge, Marian Knight
PURPOSE: To describe the incidence and outcomes to one-year in infants born with oesophageal atresia (OA) with no distal tracheoesophageal fistula within a population cohort. METHODS: A subgroup analysis of a prospective multicentre population cohort study was undertaken describing the outcomes of infants with OA and no tracheoesophageal fistula, (type A) and those with only an upper pouch fistula, (type B). MAIN RESULTS: Twenty-one of 151 infants in the whole cohort were diagnosed with type A or B oesophageal atresia (14%)...
November 13, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27821414/bronchoscopy-and-fogarty-balloon-insertion-of-distal-tracheo-oesophageal-fistula-for-oesophageal-atresia-repair-with-video-illustration
#2
Rico Rinkel, Daan Van Poll, Renate Sibarani-Ponsen, Christien Sleeboom, Roel Bakx
BACKGROUND/PURPOSE: During repair of esophageal atresia with distal tracheo-esophageal fistula, air leakage through the fistula during mechanical ventilation can cause respiratory demise. METHODS: From February 2012 until November 2014, all patients with esophageal atresia and distal tracheo-esophageal fistula were subjected to preoperative tracheobronchoscopy. Relatively distal fistulas were cannulated with a Fogarty catheter and blocked by insufflation (video illustration)...
January 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/27701787/delayed-diagnosis-an-important-prognostic-factor-for-oesophageal-atresia-in-developing-countries
#3
Suleyman Cuneyt Karakus, Bulent Hayri Ozokutan, Unal Bakal, Haluk Ceylan, Mehmet Sarac, Seval Kul, Ahmet Kazez
AIM: The aim of this study is to analyse the effect of delayed diagnosis on mortality rates, and evaluate the role of delayed diagnosis as a new prognostic factor in patients with oesophageal atresia (OA), especially in developing countries. METHODS: The records of 80 consecutive patients with OA (2008-2013) were reviewed. Patients were divided into two groups according to the time of diagnosis. As we demonstrated the effect of delayed diagnosis on mortality, we decided to develop a new classification that will be utilised to predict the prognosis of OA...
October 4, 2016: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/27699731/the-effect-of-intramural-botulinum-toxin-injections-on-the-elongation-of-the-piglet-oesophagus-is-time-dependent
#4
Christian Bakholdt Dibbern, Morten Rose, Mark Bremholm Ellebæk, Niels Qvist
Introduction One in 4,000 infants is born with oesophageal atresia. Approximately 15% of these have a long gap oesophageal atresia, where primary anastomosis is difficult or impossible. Previous studies have shown an effect of intramural botulinum toxin type A (BTX-A) injections on the elongation and max load of the esophagus 1 hour after injection. We hypothesized that a longer waiting period of 2 hours could increase this effect. Methods Forty-five piglets were randomized into three groups. Two treatment groups received 2 units/kg of BTX-A and one group received saline...
October 3, 2016: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27582496/developmental-problems-in-patients-with-oesophageal-atresia-a-longitudinal-follow-up-study
#5
Wouter J Harmsen, Femke J Aarsen, Monique H M van der Cammen-van Zijp, Joost M van Rosmalen, Rene M H Wijnen, Dick Tibboel, Hanneke IJsselstijn
OBJECTIVE: To longitudinally evaluate motor development and predictive factors in school-age children with oesophageal atresia. DESIGN: Cohort study with prospective longitudinal follow-up. SETTING: Outpatient clinic of a tertiary university paediatric hospital. PATIENTS: Children with oesophageal atresia born between January 1999 and May 2006 were assessed at 5 and 8 years of age. INTERVENTIONS: None...
August 31, 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/27544282/dysphagia-in-children-with-repaired-oesophageal-atresia
#6
Catelijne H Coppens, Lenie van den Engel-Hoek, Horst Scharbatke, Sandra A F de Groot, Jos M T Draaisma
UNLABELLED: Dysphagia is a common problem in children with repaired oesophageal atresia (OA). Abnormalities in the oropharyngeal and oesophageal phase have hardly been studied. The aims of this study were to assess the prevalence of dysphagia in children with repaired OA and to identify and differentiate oral and pharyngeal dysphagia based on videofluoroscopic swallow study (VFSS) findings in a limited number of children in this cohort. Medical records of 111 patients, born between January 1996 and July 2013 and treated at the Radboudumc Amalia Children's Hospital, were retrospectively reviewed...
September 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27502878/management-of-oesophageal-atresia-in-a-developing-country-is-primary-repair-forbidden
#7
Samuel Osei-Nketiah, Afua A J Hesse, William Appeadu-Mensah, Hope Glover-Addy, Victor K Etwire, Pokua Sarpong
BACKGROUND: The aim of the study was to evaluate the outcomes of initial surgical procedures for oesophageal atresia at our institution. Primary repair of oesophageal atresia at our centre was perceived to be associated with a high mortality rate. In view of this, almost all patients seen since January 2014 were offered initial surgery for staged repair. MATERIALS AND METHODS: A retrospective review of records of infants with oesophageal atresia seen at the centre from January 2007 to December 2014 was used in this study...
July 2016: African Journal of Paediatric Surgery: AJPS
https://www.readbyqxmd.com/read/27436264/copy-number-variations-in-375-patients-with-oesophageal-atresia-and-or-tracheoesophageal-fistula
#8
Erwin Brosens, Florian Marsch, Elisabeth M de Jong, Hitisha P Zaveri, Alina C Hilger, Vera Gisela Choinitzki, Alice Hölscher, Per Hoffmann, Stefan Herms, Thomas M Boemers, Benno M Ure, Martin Lacher, Michael Ludwig, Bert H Eussen, Robert M van der Helm, Hannie Douben, Diane Van Opstal, Rene M H Wijnen, H Berna Beverloo, Yolande van Bever, Alice S Brooks, Hanneke IJsselstijn, Daryl A Scott, Johannes Schumacher, Dick Tibboel, Heiko Reutter, Annelies de Klein
Oesophageal atresia (OA) with or without tracheoesophageal fistula (TOF) are rare anatomical congenital malformations whose cause is unknown in over 90% of patients. A genetic background is suggested, and among the reported genetic defects are copy number variations (CNVs). We hypothesized that CNVs contribute to OA/TOF development. Quantifying their prevalence could aid in genetic diagnosis and clinical care strategies. Therefore, we profiled 375 patients in a combined Dutch, American and German cohort via genomic microarray and compared the CNV profiles with their unaffected parents and published control cohorts...
July 20, 2016: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/27228265/does-continuous-positive-airway-pressure-for-extubation-in-congenital-tracheoesophageal-fistula-increase-the-risk-of-anastomotic-leak-a-retrospective-cohort-study
#9
Piyush S Shah, Parshotam Gera, Ian J Gollow, Shripada C Rao
AIM: Immediate post-operative care of tracheoesophageal fistula (TEF) and oesophageal atresia (EA) requires mechanical ventilation. Early extubation is preferred, but subsequent respiratory distress may warrant re-intubation. Continuous positive airway pressure (CPAP) is a well-established modality to prevent extubation failures in preterm infants. However, it is not favoured in TEF/EA, because of the theoretical risk of oesophageal anastomotic leak (AL). The aim of this study was to find out if post-extubation CPAP is associated with increased risk of AL...
July 2016: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/27217220/surgical-management-of-oesophageal-atresia
#10
REVIEW
Warwick J Teague, Jonathan Karpelowsky
There have been major advances in the surgery for oesophageal atresia (OA) and tracheo-oesophageal fistula(TOF) with survival now exceeding 90%. The standard open approach to OA and distal TOF has been well described and essentially unchanged for the last 60 years. Improved survival in recent decades is most attributable to advances in neonatal anaesthesia and perioperative care. Recent surgical advances include the use of thoracoscopic surgery for the repair of OA/TOF and in some centres isolated OA, thereby minimising the long term musculo-skeletal morbidity associated with open surgery...
June 2016: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/27206060/outcomes-of-oesophageal-atresia-and-tracheo-oesophageal-fistula-repair
#11
REVIEW
Kiera Roberts, Jonathan Karpelowsky, Dominic A Fitzgerald, Soundappan Sv Soundappan
Oesophageal atresia and tracheo-oesophageal fistula are congenital anomalies of the oesophagus requiring surgical repair in infancy, either by open or thoracoscopic approach. Although mortality rates associated with this procedure are low, children may go on to have complications throughout childhood and into adulthood, most commonly related to ongoing gastrointestinal and respiratory symptoms. This review outlines the early, mid and long-term outcomes for these children in terms of quality of life and incidence of symptoms...
July 2016: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/27190912/appearances-are-deceptive-passing-a-nasogastric-tube-does-not-always-rule-out-oesophageal-atresia
#12
Manish Kumar, Niranjan Thomas
Oesophageal atresia/trachea-Oesophageal fistula is commonly diagnosed in the newborn period by inability to pass a nasogastric tube (NGT). We present the instance of a newborn baby where the diagnosis of oesophageal atresia was delayed because of an apparent successful passage of nasogastric tube to the stomach. Failure to reinsert the NGT raised the suspicion of oesophageal atresia which was confirmed by contrast study showing blind upper oesophageal pouch.
April 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27090660/oesophageal-atresia-is-correctable-and-survivable-in-infants-less-than-1%C3%A2-kg
#13
Edward J Hannon, Jennifer Billington, Edward M Kiely, Agostino Pierro, Lewis Spitz, Kate Cross, Joseph I Curry, Paolo De Coppi
INTRODUCTION: Management of oesophageal atresia (OA) and trachea-oesophageal fistula (TOF) in babies of low birth weight is challenging especially when associated with other anomalies. Birth weight of <1500 g has previously formed part of a classification system designed to predict outcome, alongside the cardiac status of the patient. Improvements in neonatal care have led to increasing numbers of premature low birth weight infants surviving. The aim of this study was to look at the experience of our institution in the extremely low birth weight (ELBW) patients...
June 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27084730/the-genetic-landscape-and-clinical-implications-of-vertebral-anomalies-in-vacterl-association
#14
REVIEW
Yixin Chen, Zhenlei Liu, Jia Chen, Yuzhi Zuo, Sen Liu, Weisheng Chen, Gang Liu, Guixing Qiu, Philip F Giampietro, Nan Wu, Zhihong Wu
VACTERL association is a condition comprising multisystem congenital malformations, causing severe physical disability in affected individuals. It is typically defined by the concurrence of at least three of the following component features: vertebral anomalies (V), anal atresia (A), cardiac malformations (C), tracheo-oesophageal fistula (TE), renal dysplasia (R) and limb abnormalities (L). Vertebral anomaly is one of the most important and common defects that has been reported in approximately 60-95% of all VACTERL patients...
July 2016: Journal of Medical Genetics
https://www.readbyqxmd.com/read/26932255/accuracy-of-prenatal-detection-of-tracheoesophageal-fistula-and-oesophageal-atresia
#15
Catherine J Bradshaw, Hemanshoo Thakkar, Liz Knutzen, Rachel Marsh, Maurizio Pacilli, Laurence Impey, Kokila Lakhoo
AIMS: This study aims to determine the rate of prenatal detection of tracheoesophageal fistula and oesophageal atresia (TOF/OA), by identifying a small or absent stomach bubble with or without polyhydramnios, on the prenatal ultrasound scans (USS). METHODS: A retrospective study of prenatal ultrasound findings of babies with a prenatal and postnatal diagnosis of TOF/OA born between 1st January 2004 and 31st December 2013 was undertaken. RESULTS: A total of 58 babies were born with TOF/OA...
August 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/26921973/-oesophageal-atresia-we-need-to-be-seeing-ya
#16
EDITORIAL
Dominic A Fitzgerald, Jonathan Karpelowsky
No abstract text is available yet for this article.
June 2016: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/26921972/peri-operative-management-of-neonates-with-oesophageal-atresia-and-tracheo-oesophageal-fistula
#17
REVIEW
Rod W Hunt, Elizabeth J Perkins, Sebastian King
Oesphageal atresia is a relatively common congenital anomaly that requires urgent diagnosis, transfer to a neonatal surgical centre and management by a multidisciplinary team. Peri-operative management requires vigilant monitoring for the many possible associated morbidities. There are unique anaesthetic, airway and ventilatory considerations for this group of patients. Beyond the perinatal period, systematic neurodevelopmental follow-up is recommended to better understand the longer term outcomes for these children...
June 2016: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/26826758/-management-of-gastroesophageal-reflux-in-children-single-centre-experience-in-conventional-and-laparoscopic-nissen-fundoplication-in-the-last-15-years
#18
J E Betancourth-Alvarenga, J I Garrido Pérez, A L Castillo Fernández, F J Murcia Pascual, M A Cárdenas Elias, A Escassi Gil, R M Paredes-Esteban
INTRODUCTION: Nissen fundoplication (NF) is the most used and effective technique for the treatment of gastroesophageal reflux in children. The laparoscopic approach (LNF) is safe, with low morbidity and high success rate, although some cases require a conventional approach (CNF). The aim of the study is to compare the results between LNF and CNF in our centre. MATERIAL AND METHODS: A retrospective review was performed on patients <14years after NF between 2000 and 2015...
January 27, 2016: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/26783085/challenges-of-management-and-outcome-of-neonatal-surgery-in-africa-a-systematic-review
#19
Sebastian O Ekenze, Obinna V Ajuzieogu, Benedict C Nwomeh
BACKGROUND: Disparity still exists in the outcome of neonatal surgery between high-income countries and low-income and middle-income countries. This study reviews publications on neonatal surgery in Africa over 20 years with a focus on challenges of management, trends in outcome, and potential interventions to improve outcome. METHODS: We did a literature review by searching PubMed and African Index Medicus for original articles published in any language between January 1995 and September 2014...
March 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/26761945/a-newly-discovered-mutation-in-the-rfx6-gene-of-the-rare-mitchell-riley-syndrome
#20
Nusrat Khan, Waleed Dandan, Noura Al Hassani, Suha Hadi
Mitchell-Riley syndrome is a genetic disorder characterized by neonatal diabetes, pancreatic hypoplasia, intestinal atresia and/or malrotation, biliary atresia, and gallbladder aplasia or hypoplasia. It was considered a variant of the Martinez-Frias syndrome with similar phenotypic characteristics, except for neonatal diabetes and tracheoesophageal fistula. However, the genetic mutation in (regulatory factor X on chromosome 6) RFX6 was only detected in babies who had diabetes, making it different from the previously known mutations for the disease...
June 5, 2016: Journal of Clinical Research in Pediatric Endocrinology
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