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Oesophageal atresia

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https://www.readbyqxmd.com/read/28503544/update-on-foregut-molecular-embryology-and-role-of-regenerative-medicine-therapies
#1
REVIEW
Silvia Perin, Conor J McCann, Osvaldo Borrelli, Paolo De Coppi, Nikhil Thapar
Esophageal atresia (OA) represents one of the commonest and most severe developmental disorders of the foregut, the most proximal segment of the gastrointestinal (GI) tract (esophagus and stomach) in embryological terms. Of intrigue is the common origin from this foregut of two very diverse functional entities, the digestive and respiratory systems. OA appears to result from incomplete separation of the ventral and dorsal parts of the foregut during development, resulting in disruption of esophageal anatomy and frequent association with tracheo-oesophageal fistula...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28499713/long-term-outcomes-of-oesophageal-atresia-without-or-with-proximal-tracheooesophageal-fistula-gross-types-a-and-b
#2
A I Koivusalo, S J Sistonen, H G Lindahl, R J Rintala, M P Pakarinen
PURPOSE: Because of an extended gap between esophageal pouches a variety of methods are employed to treat oesophageal atresia (OA) without (type A) or with (type B) proximal tracheooesophageal fistula. This retrospective observational study describes their single centre long-term outcomes from 1947 to 2014. METHODS: Of 693 patients treated for OA 68 (9.7%) had type A (n=58, 8.3%) or B (n=10, 1.4%). Hospital records were reviewed. Main outcome measures were survival and oral intake...
May 1, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28447027/gastric-function-in-children-with-oesophageal-atresia-and-tracheoesophageal-fistula
#3
REVIEW
Gilles Duvoisin, Usha Krishnan
Oesophageal atresia and tracheoesophageal fistula (OA-TOF) are a multifaceted condition which affects patients throughout their lives. Even though it is one of the most common gastrointestinal malformations, most of the current studies focus on gastro-oesophageal reflux disease, anastomotic strictures, and feeding difficulties. However, there is increasing evidence that a proportion of patients with OA-TOF also have abnormal gastric function. This review aims to provide a comprehensive understanding of studies of gastric function in patients with OA-TOF...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28446132/pcsk5-is-required-in-the-early-cranio-cardiac-mesoderm-for-heart-development
#4
Dorota Szumska, Milena Cioroch, Angela Keeling, Annik Prat, Nabil G Seidah, Shoumo Bhattacharya
BACKGROUND: Loss of proprotein convertase subtilisin/kexin type 5 (Pcsk5) results in multiple developmental anomalies including cardiac malformations, caudal regression, pre-sacral mass, renal agenesis, anteroposterior patterning defects, and tracheo-oesophageal and anorectal malformations, and is a model for VACTERL/caudal regression/Currarino syndromes (VACTERL association - Vertebral anomalies, Anal atresia, Cardiac defects, Tracheoesophageal fistula and/or Esophageal atresia, Renal & Radial anomalies and Limb defects)...
April 26, 2017: BMC Developmental Biology
https://www.readbyqxmd.com/read/28303723/decellularized-material-as-scaffolds-for-tissue-engineering-studies-in-long-gap-esophageal-atresia
#5
Esmond Lee, Anna Milan, Luca Urbani, Paolo De Coppi, Mark W Lowdell
Esophageal atresia refers to an anomaly in foetal development in which the esophagus terminates in a blind end. Whilst surgical correction is achievable in most patients, when a long gap is present it still represents a major challenge associated with higher morbidity and mortality. In this context, tissue engineering could represent a successful alternative to restore oesophageal function and structure. Naturally derived biomaterials made of decellularized tissues retain native extracellular matrix architecture and composition, providing a suitable bed for the anchorage and growth of relevant cell types...
March 27, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28292964/longitudinal-evaluation-of-growth-in-oesophageal-atresia-patients-up-to-12%C3%A2-years
#6
Floor W T Vergouwe, Marjolein Spoel, Nicole W G van Beelen, Saskia J Gischler, René M H Wijnen, Joost van Rosmalen, Hanneke IJsselstijn
OBJECTIVE: Previous studies reported diminished growth after oesophageal atresia (OA) repair. We evaluated long-term follow-up data on growth. METHODS: Longitudinal cohort study up to 12 years. Patients with OA, born 1999-2013, who participated in a longitudinal follow-up programme were included. Children with genetic syndromes associated with growth disorders were excluded. SD scores (SDS) for height-for-age (HFA), weight-for-height (WFH) and distance-to-target-height were calculated for routine visits (0...
March 14, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28205731/p-19-impaired-pulmonary-function-and-ventilatory-limitation-in-children-with-successfully-repaired-oesophageal-atresia
#7
J McBride, P Field, C Clarkson, J Menzies, J Hughes, M Doumit, C Wu, S Adams, M Soma, U Krishnan, Y Belessis
No abstract text is available yet for this article.
April 1, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28205723/p-14-the-mortality-of-oesophageal-atresia-results-from-726-patients-1970-2013
#8
S K King, A Hawley, J Brooks, M Nightingale, E Mcleod, T Clarnette, R Taylor, J Crameri, A Pellicano
No abstract text is available yet for this article.
April 1, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28205711/p-18-two-year-neurodevelopmental-outcome-following-neonatal-repair-of-oesophageal-atresia
#9
J K Gunn, S Greaves, E A Hutchinson, L M Kelly, M M Moran, A K Chisholm, R W Hunt
No abstract text is available yet for this article.
April 1, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28205708/p-36-quality-of-life-family-impact-and-parental-satisfaction-with-multidisciplinary-care-in-children-with-oesophageal-atresia
#10
L McLennan, C Clarkson, J Menzies, J Hughes, M Doumit, C Wu, S Adams, M Soma, U Krishnan, Y Belessis
No abstract text is available yet for this article.
April 1, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28205705/o-02-16-17-to-16-29-late-deaths-in-patients-with-oesophageal-atresia-results-from-553-patients-1980-2013
#11
S K King, A Hawley, J Brooks, M Nightingale, E Mcleod, T Clarnette, R Taylor, J Crameri, A Pellicano
No abstract text is available yet for this article.
April 1, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28205703/p-05-a-case-study-of-long-gap-oesophageal-atresia-followed-to-adulthood
#12
M Steven, R Carachi
No abstract text is available yet for this article.
April 1, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28205697/o-07-17-17-to-17-29-trends-in-utilisation-of-fundoplication-in-oesophageal-atresia-lessons-from-329-patients-1994-to-2013
#13
S K King, W Teague, A Hawley, J Brooks, M Nightingale, E Mcleod, T Clarnette, R Taylor, J Crameri
No abstract text is available yet for this article.
April 1, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28205695/o-05-16-53-to-17-05-long-gap-oesophageal-atresia-is-oesophageal-replacement-still-the-best-option
#14
H A Abdelkader, R Carachi
No abstract text is available yet for this article.
April 1, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28012691/multicentre-survey-on-the-current-surgical-management-of-oesophageal-atresia-in-belgium-and-luxembourg
#15
Helena Reusens, Lucas Matthyssens, Charlotte Vercauteren, Katrien van Renterghem
INTRODUCTION: The surgical management of oesophageal atresia (OA) differs between pediatric surgical teams without consensus. We aimed to describe the current practice of OA treatment in Belgium and Luxembourg and compare this to the literature. MATERIALS AND METHODS: A questionnaire was created and sent to all 18 hospitals (14 pediatric surgical units) performing OA surgery in Belgium and Luxembourg. The results were compared to the literature. RESULTS: Most units treat an average of 2-5 OA+TOF (71%) and ≤1 pure OA (pOA) per year (86%)...
February 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27939205/characterization-of-the-upper-pouch-tracheo-oesophageal-fistula-in-oesophageal-atresia
#16
Virginia Summerour, Paul S Stevens, Anthony D Lander, Michael Singh, Giampiero Soccorso, G Suren Arul
AIM: A small proportion of infants with oesophageal atresia (OA) are thought to have a proximal tracheoesophageal fistula (TOF). Failure to recognize these can hamper mobilization of the upper pouch and lead to life-threatening episodes of aspiration once oral feeding starts. We reviewed our experience of upper pouch fistulae to identify characteristic features of proximal TOF. METHODS: A retrospective review of TOF/OA patient notes and bronchoscopy photographs and videos, identified from our database from 01/01/2006 to 12/31/2015, was performed...
February 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27894760/oesophageal-atresia-with-no-distal-tracheoesophageal-fistula-management-and-outcomes-from-a-population-based-cohort
#17
MULTICENTER STUDY
Anna-May Long, Athanasios Tyraskis, Benjamin Allin, David M Burge, Marian Knight
PURPOSE: To describe the incidence and outcomes to one-year in infants born with oesophageal atresia (OA) with no distal tracheoesophageal fistula within a population cohort. METHODS: A subgroup analysis of a prospective multicentre population cohort study was undertaken describing the outcomes of infants with OA and no tracheoesophageal fistula, (type A) and those with only an upper pouch fistula, (type B). MAIN RESULTS: Twenty-one of 151 infants in the whole cohort were diagnosed with type A or B oesophageal atresia (14%)...
February 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27821414/bronchoscopy-and-fogarty-balloon-insertion-of-distal-tracheo-oesophageal-fistula-for-oesophageal-atresia-repair-with-video-illustration
#18
Rico Rinkel, Daan Van Poll, Renate Sibarani-Ponsen, Christien Sleeboom, Roel Bakx
BACKGROUND/PURPOSE: During repair of esophageal atresia with distal tracheo-esophageal fistula, air leakage through the fistula during mechanical ventilation can cause respiratory demise. METHODS: From February 2012 until November 2014, all patients with esophageal atresia and distal tracheo-esophageal fistula were subjected to preoperative tracheobronchoscopy. Relatively distal fistulas were cannulated with a Fogarty catheter and blocked by insufflation (video illustration)...
January 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/27701787/delayed-diagnosis-an-important-prognostic-factor-for-oesophageal-atresia-in-developing-countries
#19
Suleyman Cuneyt Karakus, Bulent Hayri Ozokutan, Unal Bakal, Haluk Ceylan, Mehmet Sarac, Seval Kul, Ahmet Kazez
AIM: The aim of this study is to analyse the effect of delayed diagnosis on mortality rates, and evaluate the role of delayed diagnosis as a new prognostic factor in patients with oesophageal atresia (OA), especially in developing countries. METHODS: The records of 80 consecutive patients with OA (2008-2013) were reviewed. Patients were divided into two groups according to the time of diagnosis. As we demonstrated the effect of delayed diagnosis on mortality, we decided to develop a new classification that will be utilised to predict the prognosis of OA...
December 2016: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/27699731/the-effect-of-intramural-botulinum-toxin-injections-on-the-elongation-of-the-piglet-oesophagus-is-time-dependent
#20
Christian Bakholdt Dibbern, Morten Rose, Mark Bremholm Ellebæk, Niels Qvist
Introduction One in 4,000 infants is born with oesophageal atresia. Approximately 15% of these have a long gap oesophageal atresia, where primary anastomosis is difficult or impossible. Previous studies have shown an effect of intramural botulinum toxin type A (BTX-A) injections on the elongation and max load of the esophagus 1 hour after injection. We hypothesized that a longer waiting period of 2 hours could increase this effect. Methods Forty-five piglets were randomized into three groups. Two treatment groups received 2 units/kg of BTX-A and one group received saline...
February 2017: European Journal of Pediatric Surgery
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