keyword
https://read.qxmd.com/read/37093910/effectiveness-of-pegylated-interferon-alpha-2a-in-post-uveitic-macular-edema-previously-responding-to-non-pegylated-interferon
#21
JOURNAL ARTICLE
L De Simone, P Gentile, R Aldigeri, V Mastrofilippo, E Bolletta, F Gozzi, C Adani, C Salvarani, L Cimino
PURPOSE: To evaluate the efficacy of pegylated interferon (PEG-IFN) alpha-2a to treat post-uveitic relapsing macular edema (ME) after withdrawal of non-PEG IFN alpha-2a or 2b to maintain treatment efficacy. METHODS: This retrospective study investigated subjects with post-uveitic ME who received weekly subcutaneous PEG-IFN alpha-2a injections. Comparisons between baseline central macular thickness (CMT) and best-corrected visual acuity (BCVA) and those at all follow-up visits were made...
April 24, 2023: Ocular Immunology and Inflammation
https://read.qxmd.com/read/37093650/vitreoretinal-surgery-in-uveitis-from-old-to-new-concepts-a-review
#22
JOURNAL ARTICLE
Thiago José Muniz Machado Mazzeo, Raimunda Cristina Mendonça Freire, Cleide Guimarães Machado, André Marcelo Vieira Gomes, André Luiz Land Curi
PURPOSE: The aim of this article is to do a comprehensive literature review about the current role of pars plana vitrectomy in uveitis and in its different structural complications such as cystoid macular edema, epiretinal membrane, macular hole, and retinal detachment. METHODS: This comprehensive literature review was performed based on a search on PubMed, BioMed Central, Science Open, and CORE databases, of relevant articles abording pars plana vitrectomy in uveitis...
April 24, 2023: Ocular Immunology and Inflammation
https://read.qxmd.com/read/37083589/intravitreal-versus-oral-steroids-for-inflammation-control-in-uveitic-patients-undergoing-cataract-surgery
#23
JOURNAL ARTICLE
Muhammad Usman Jamil, Uzma Naz, Saliha Naz
BACKGROUND: This prospective experimental study was conducted on 40 eyes of 40 patients with complicated uveitic cataracts to compare a single intraoperative intravitreal injection of triamcinolone acetonide (IVTA) with oral steroids for inflammation control after cataract extraction. METHODS: The IVTA group (19 eyes) received an intravitreal injection of 4 mg/0.1 ml triamcinolone acetonide intraoperatively, and the oral steroid group (19 eyes) received oral steroids peri-operatively...
April 21, 2023: Ocular Immunology and Inflammation
https://read.qxmd.com/read/37041711/a-case-report-of-concurrent-pyostomatitis-vegetans-like-intercellular-immunoglobulin-a-dermatosis-and-uveitic-macular-edema-reacting-exclusively-with-desmocollins-a-possible-common-pathogenesis
#24
JOURNAL ARTICLE
Xavier Bosch-Amate, Pilar Iranzo-Fernández, José Manuel Mascaró, Norito Ishii, Takashi Hashimoto
No abstract text is available yet for this article.
April 2023: Annals of Dermatology
https://read.qxmd.com/read/36902105/interleukin-6-and-macular-edema-a-review-of-outcomes-with-inhibition
#25
REVIEW
Janine Yunfan Yang, David Goldberg, Lucia Sobrin
This paper describes the current literature on the molecular pathophysiology of interleukin-6 (IL-6) in the genesis of macular edema and on the outcomes with IL-6 inhibitors in the treatment of non-infectious macular edema. The role of IL-6 in the development of macular edema has been well elucidated. IL-6 is produced by multiple cells of the innate immune system and leads to a higher likelihood of developing autoimmune inflammatory diseases, such as non-infectious uveitis, through a variety of mechanisms. These include increasing the helper T-cell population over the regulatory T-cell population and leading to the increased expression of inflammatory cytokines, such as tumor necrosis factor-alpha...
February 28, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36873888/efficacy-and-safety-of-single-dose-intravitreal-dexamethasone-implant-in-non-infectious-uveitic-macular-edema-a-systematic-review-and-meta-analysis
#26
Shipei Fan, Xing-Yu Shi, Chao-Fu Zhao, Zhen Chen, Jia Ying, Song-Ping Yu, Jun Li, Xia Li
PURPOSE: We conducted a systematic review and meta-analysis to investigate the efficacy and safety of single-dose intravitreal dexamethasone (DEX) implant for treating non-infectious uveitic macular edema (UME). METHODS: Studies including clinical outcomes of the DEX implant in UME were comprehensively searched in PubMed, Embase, and Cochrane databases for potential studies from inception to July 2022. The primary outcomes were best corrected visual acuity (BCVA) and central macular thickness (CMT) during the follow-up period...
2023: Frontiers in Medicine
https://read.qxmd.com/read/36822573/glaucoma-drainage-device-surgery-outcomes-in-children-with-uveitic-glaucoma
#27
JOURNAL ARTICLE
Evangelia Gkaragkani, Hari Jayaram, Maria Papadopoulos, Carlos Pavesio, John Brookes, Peng T Khaw, Yasmine M El Sayed, Jonathan Clarke
PURPOSE: To evaluate outcomes of glaucoma drainage device (GDD) implantation children with uveitic glaucoma. DESIGN: Retrospective interventional case series METHODS: : Success defined as IOP ≥5 and ≤21 mmHg. Failure defined at final follow up when IOP was outside the success criteria, visual function was NPL or further glaucoma surgery (excluding removal of intraluminal stent suture or needling). RESULTS: 50 eyes of 36 children with uveitic glaucoma underwent GDD implantation...
February 21, 2023: American Journal of Ophthalmology
https://read.qxmd.com/read/36731509/a-period-of-macular-hyperemia-and-subclinical-edema-caused-by-phacoemulsification-surgery-in-noninfectious-uveitis
#28
JOURNAL ARTICLE
Mali Dai, Kemi Feng, Xingneng Guo, Junyong Cai, Xianhui Gong, Nishimwe Anodine Daliko, Yuqin Wang
PURPOSE: To identify the changes in macular microvasculature in uveitic patients following phacoemulsification. METHODS: A prospective cohort study was conducted by enrolling uveitic patients who underwent phacoemulsification at the Eye Hospital. Macular vessel densities (VD) of superficial and deep capillary plexus (SCP and DCP) and retinal thickness (RT) were quantified by optical coherence tomographic angiography (OCTA). RESULTS: Twenty-one eyes obtained satisfactory OCTA scans at all the follow-up visits...
February 2, 2023: Ocular Immunology and Inflammation
https://read.qxmd.com/read/36642624/-sarcoid-uveitis-ophthalmologist-s-and-internist-s-viewpoints
#29
REVIEW
P Sève, R Jacquot, T El Jammal, A Bert, Y Jamilloux, L Kodjikian, S Giorgiutti
Sarcoidosis is one of the leading causes of inflammatory eye disease. All ocular structures can be affected, but uveitis is the main manifestation responsible for vision loss in ocular sarcoidosis. Typical sarcoid anterior uveitis presents with mutton-fat keratic precipitates, iris nodules, and posterior synechiae. Posterior involvement includes vitritis, vasculitis, and choroidal lesions. Cystoid macular edema is the most important and sight-threatening consequence of sarcoid uveitis. Patients with clinically isolated uveitis at diagnosis rarely develop other organ involvement...
March 2023: La Revue de Médecine Interne
https://read.qxmd.com/read/36642594/uveitis-in-children-epidemiological-clinical-and-prognostic-characteristics
#30
JOURNAL ARTICLE
C Rodier-Bonifas, E Rochet, P Seve, A Duquesne, A-M Nguyen, P Denis, L Kodjikian, T Mathis
PURPOSE: The purpose of this study is to describe the characteristics and prognostic factors of pediatric uveitis in a French university referral hospital. METHODS: We performed a retrospective study of all cases of all pediatric uveitis seen at our institution over a 7-year period. RESULTS: A total of 141 eyes of 86 children were included. The mean age was 10.7 years, and 61.6% were girls. The uveitis was bilateral in 64.0% of cases. Anterior uveitis (41...
January 13, 2023: Journal Français D'ophtalmologie
https://read.qxmd.com/read/36622871/cerebro-ocular-toxocariasis-revealed-by-bilateral-cystoid-macular-edema
#31
JOURNAL ARTICLE
Arianna Paris, Miguel Hié, Ramin Tadayoni, Bahram Bodaghi, Sara Touhami
DESIGN: Case Report Case description: This report describes the case of a female patient diagnosed with oculo-cerebral toxocariasis manifesting initially in the form of isolated bilateral cystoid macular edema. Diagnosis was made by means of positive anterior chamber and lumbar puncture western blots. The unusual presentation, ancillary findings and treatment are discussed. The control of intraocular inflammation that was only partially responsive to steroids was eventually achieved with pegylated interferon alfa-2a...
January 9, 2023: Ocular Immunology and Inflammation
https://read.qxmd.com/read/36588192/the-large-hellenic-study-of-uveitis-diagnostic-and-therapeutic-algorithms-complications-and-final-outcome
#32
JOURNAL ARTICLE
Dimitrios Kalogeropoulos, Ioannis Asproudis, Maria Stefaniotou, Marilita M Moschos, Vassilios P Kozobolis, Paraskevi V Voulgari, Andreas Katsanos, Constantina Gartzonika, Chris Kalogeropoulos
PURPOSE: The purpose of this study is to present the diagnostic and therapeutic algorithms, complications, and final outcome in the management of uveitic patients at a tertiary academic referral center. DESIGN: Observational study. METHODS: Analysis of the archives of 6191 uveitic patients at the Ocular Inflammation Service of the Department of Ophthalmology of the University Hospital of Ioannina in Greece from 1991 to 2020. RESULTS: During the 30 years of the study, the diagnostic ability climbed from 45...
January 2023: Asia-Pacific Journal of Ophthalmology
https://read.qxmd.com/read/36565328/immunity-status-and-expression-of-molecular-markers-icam-1-cd5-cd25-cd95-on-lymphocytes-of-patients-with-recurrent-anterior-uveitis-complicated-by-macular-edema
#33
JOURNAL ARTICLE
Natalia I Khramenko, Natalia V Konovalova, Volodymyr Ya Usov, Liudmyla M Velychko, Olexandra V Bogdanova
BACKGROUND: Treatment of macular edema in uveitis is a key goal of treatment, because this complication remains a potential therapeutic problem for specialists. MATERIAL AND METHODS: Examination was carried out in 1-2 groups - 50 persons with uncomplicated recurrent anterior uveitis (AU) in the stage of relapse or remission - and 3-4 groups - 26 persons with recurrent AU complicated by uveitic macular edema (UME) in the stage of relapse or remission of AU. Control group - 27 healthy volunteers...
December 24, 2022: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/36549244/anti-tnf-vs-tocilizumab-in-refractory-uveitic-cystoid-macular-edema-due-to-behcet-s-disease-multicenter-study-of-49-patients
#34
REVIEW
Nuria Barroso-García, Belén Atienza-Mateo, Iván Ferraz-Amaro, Diana Prieto-Peña, Emma Beltrán, Alfredo Adán, Marisa Hernández-Garfella, Lucía Martínez-Costa, Miguel Cordero-Coma, Manuel Díaz-Llopis, José M Herreras, Olga Maíz-Alonso, Ignacio Torre-Salaberri, Ana De Vicente-Delmás, David Díaz-Valle, Antonio Atanes-Sandoval, Félix Francisco, Santos Insua, Julio Sánchez, Raquel Almodóvar-González, Alejandro Jiménez-Sosa, Oscar Ruiz-Moreno, Myriam Gandía-Martínez, Joan M Nolla, Vanesa Calvo-Río, Santos Castañeda, Miguel A González-Gay, Ricardo Blanco
OBJECTIVE: To compare the efficacy of TNF inhibitors (adalimumab (ADA) and infliximab (IFX)) vs tocilizumab (TCZ) in patients with refractory cystoid macular edema (CME) due to Behçet's disease (BD). METHODS: Multicenter study of patients with BD-associated CME refractory to conventional and/or biological immunosuppressive drugs. From a cohort of 177 patients treated with anti-TNF and 14 patients treated with TCZ, we selected those with CME at baseline. We analyzed the evolution of macular thickness (main outcome), best-corrected visual acuity (BCVA) and intraocular inflammation (Tyndall and vitritis) from baseline up to 4 years in the 3 groups mentioned...
February 2023: Seminars in Arthritis and Rheumatism
https://read.qxmd.com/read/36453344/topical-interferon-therapy-in-uveitic-macular-edema
#35
JOURNAL ARTICLE
Ankush Kawali, Srinivasan Sanjay, Ashwin Mohan, Padmamalini Mahendradas, Rohit Shetty
PURPOSE: To evaluate efficacy of topical interferon alfa-2b (IFN) in the treatment of uveitic macular edema (UME). METHODS: This is a prospective, interventional case study of patients with UME. Injection IFN was reconstituted into eye drops and a four times/day (QID) application was prescribed. Central macular thickness (CMT) on optical coherence tomography (OCT) scan was evaluated. Improvement in CMT by ≥50 μm from the baseline was studied in eyes with presenting CMT ≥400 μm...
December 2022: Indian Journal of Ophthalmology
https://read.qxmd.com/read/36399237/triamcinolone-acetonide-suprachoroidal-injectable-suspension-for-uveitic-macular-edema-integrated-analysis-of-two-phase-3-studies
#36
JOURNAL ARTICLE
Steven Yeh, Christopher R Henry, Barry Kapik, Thomas A Ciulla
INTRODUCTION: Macular edema, a common complication of uveitis, may result in vision loss. The aim of this analysis was to report integrated phase 3 trial data for triamcinolone acetonide injectable suspension for suprachoroidal use (SCS-TA) in the treatment of macular edema secondary to noninfectious uveitis using strict inclusion criteria. METHODS: This analysis included patients with central subfield thickness (CST) ≥ 300 µm and best-corrected visual acuity (BCVA) of ≥ 5 and ≤ 70 Early Treatment Diabetic Retinopathy Study (ETDRS) letters at both screening and baseline who received ≥ 1 study treatment in either PEACHTREE (randomized, double-masked SCS-TA or sham control) or AZALEA (open-label SCS-TA)...
November 18, 2022: Ophthalmology and Therapy
https://read.qxmd.com/read/36394901/targeting-the-suprachoroidal-space-in-treating-noninfectious-uveitic-macular-edema
#37
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
December 1, 2022: Retina
https://read.qxmd.com/read/36308129/long-term-outcomes-of-small-incision-cataract-surgery-in-patients-with-uveitis
#38
JOURNAL ARTICLE
Rahul Bhargava, Kankambari Pandey, Bhavya Mehta
PURPOSE: To evaluate the long-term outcomes of manual small-incision cataract surgery (MSICS) in eyes with uveitis. METHODS: Patients who underwent MSICS for uveitic cataract from 2009 to 2019 were retrospectively evaluated. Visually significant cataract and presence of less than five cells per high-power field in the anterior chamber for a minimum of 3 months were the prerequisites for surgery. Patients with follow-up less than 9 months were excluded. RESULTS: After exclusion, 283 eyes of 264 patients were evaluated...
November 2022: Indian Journal of Ophthalmology
https://read.qxmd.com/read/36266560/therapeutic-response-after-immunosuppressive-drug-prescription-in-non-infectious-uveitis-a-survival-analysis
#39
JOURNAL ARTICLE
Alejandro Gómez-Gómez, Alfredo Madrid-Garcia, Lara Borrego-Sanz, Paula Álvarez-Hernández, Pedro Arriola-Villalobos, Inés Pérez-Sancristobal, José M Benítez Del Castillo, Rosalía Mendez-Fernandez, Esperanza Pato-Cour, David Díaz-Valle, Luis Rodriguez-Rodriguez
INTRODUCTION: To identify factors affecting the response rate to immunosuppressive drugs (ISDs) in patients with non-infectious uveitis (NIU). METHODS: This longitudinal retrospective cohort study included patients from the Hospital Clinico San Carlos Uveitis Clinic diagnosed with NIU from 1992 to 2016. Subjects were followed up from ISD prescription until the achievement of good therapeutic response (GTR), ISD treatment change, or up to 12 months. GTR was defined as the complete resolution of the eye inflammatory manifestations with a corticosteroid dose ≤ 10 or ≤ 5 mg per day of prednisone or equivalent (GTR10 and GTR5, respectively) maintained for at least 28 days...
October 20, 2022: Ophthalmology and Therapy
https://read.qxmd.com/read/36266145/update-on-the-utility-of-en-face-optical-coherence-tomography-in-the-assessment-of-vitreoretinal-diseases
#40
REVIEW
C Oribio-Quinto, J I Fernández-Vigo, C Perálvarez Conde, D Rego-Lorca, J Donate-López, L López-Guajardo
En face optical coherence tomography (EF-OCT) is a rapid, non-invasive, high-resolution imaging technique that has evolved in recent years to be a routine examination for the assessment and follow-up of various vitreoretinal diseases. With the introduction of swept-source OCT (SS-OCT), which can achieve up to 100,000 A-scans per second and better-quality imaging of deeper structures using a longer wavelength (1050nm), EF-OCT reconstruction can produce high-resolution frontal images of the retina and choroid (C-Scans) that give an overview of disease extent...
October 17, 2022: Journal Français D'ophtalmologie
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