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Uveitic macular edema

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https://www.readbyqxmd.com/read/28755068/-intravitreal-methotrexate-for-treatment-of-uveitic-cystoid-macular-edema
#1
J Maaß, E Matthé
We present the case of a patient who had several intravitreal methotrexate injections due to a uveitic macular edema and a known steroid response. An earlier off-label therapy with avastin had not been successful. After the intravitreal methotrexate injections a good resorption of the retinal fluid as well as a good intraocular pressure and a good visual acuity could be achieved. Visual acuity was limited by pre-existing glaucomatous optic nerve atrophy and a central scar in the cornea.
July 28, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28557602/systemic-steroid-sparing-effect-of-intravitreal-dexamethasone-implant-in-chronic-noninfectious-uveitic-macular-edema
#2
Claudia Fabiani, Antonio Vitale, Giacomo Emmi, Giuseppe Lopalco, Lorenzo Vannozzi, Daniela Bacherini, Silvana Guerriero, Rosa Anna Favale, Fiorella Fusco, Rossella Franceschini, Bruno Frediani, Florenzo Iannone, Mauro Galeazzi, Gian Marco Tosi, Luca Cantarini
PURPOSE: To evaluate the effectiveness and the systemic corticosteroid sparing effect of a single intravitreal dexamethasone (DEX) implant in patients with chronic noninfectious uveitic macular edema (UME). METHODS: Data from 22 eyes treated with DEX implant for UME related to systemic or ocular-confined noninfectious diseases were retrospectively analyzed. RESULTS: The mean systemic prednisone (or equivalent) dosage significantly decreased at 3- and 6-month follow-up evaluations compared to baseline (P = 0...
May 30, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28419393/role-of-disorganization-of-retinal-inner-layers-as-an-optical-coherence-tomography-biomarker-in-diabetic-and-uveitic-macular-edema
#3
Dilraj S Grewal, Seenu M Hariprasad, Glenn J Jaffe
No abstract text is available yet for this article.
April 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28351051/insights-into-the-physiopathology-of-inflammatory-macular-edema
#4
REVIEW
Marc D de Smet
Macular edema is one of the most common causes of permanent vision loss in patients with uveitis. The current understanding of water balance and metabolism within the retina has given us better insight into the mechanisms underlying macular edema arising from both acute and chronic inflammation. Uveitic macular edema (UME) occurs when the equilibrium between water influx and efflux is lost, and more importantly when compensatory mechanisms are overwhelmed. While in the acute setting, control of inflammation can reestablish homeostasis, chronic inflammation can lead to alternate pathways to establish a water balance...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28237411/association-of-disorganization-of-retinal-inner-layers-with-visual-acuity-in-eyes-with-uveitic-cystoid-macular-edema
#5
RANDOMIZED CONTROLLED TRIAL
Dilraj S Grewal, Matthew L O'Sullivan, Martina Kron, Glenn J Jaffe
PURPOSE: To determine whether disorganization of retinal inner layers (DRIL) assessed by spectral-domain optical coherence tomography (SDOCT) correlates with visual acuity (VA) in eyes with uveitic cystoid macular edema (CME). DESIGN: Secondary analysis of randomized clinical trial data. METHODS: Fifty-six eyes of 42 patients with uveitic CME were prospectively imaged as part of the VISUAL-1 trial (Clinicaltrials.gov identifier NCT01138657)...
May 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28165851/intravitreal-antiangiogenic-therapy-of-uveitic-macular-edema-a-review
#6
Igor Kozak, Samir S Shoughy, Donald U Stone
Uveitic (or inflammatory) macular edema (UME) is one of the most common cause of visual impairment in patients with uveitis and the most frequent structural complication of uveitis. The use of antiangiogenic agents in the management of macular edema due to inflammation is a fairly new approach. It is not entirely clear if these agents should be used as an adjunct to anti-inflammatory therapy or if they can be used as stand-alone agents in edema due to infections where immunosuppressive therapy could be detrimental to the resolution of infection...
May 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28127443/the-unusual-association-of-inverse-retinitis-pigmentosa-and-fuchs-heterochromic-iridocyclitis
#7
Gian Franco Díez-Cattini, David Arturo Ancona-Lezama, Carlos Valdés-Lara, Virgilio Morales-Cantón
BACKGROUND: Classic retinitis pigmentosa (RP) and other syndromic variants have previously been associated to Fuchs' heterochromic iridocyclitis (FHI). Common immunogenic and inflammatory pathways have been proposed to explain the higher incidence of this uveitic phenomenon in patients with retinal dystrophies without definitive answers. Infrequent variants of RP such as inverse RP have not been previously reported in association with FHI. We believe that finding the way these entities connect can shed some light into their complex pathogenesis and help find ways to foresee and prevent the appearance of complications such as cataract and macular edema...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28112568/vitrectomy-for-epiretinal-membranes-and-macular-holes-in-uveitis-patients
#8
Sara V Branson, Brendan R McClafferty, Shree K Kurup
PURPOSE: Macular pathology, including macular holes (MHs), epiretinal membranes (ERMs), and macular edema, is a cause of irreversible vision loss in the setting of uveitis. Medical management involves corticosteroids, immunomodulatory medications, and biologics to control inflammation. Pars plana vitrectomy (PPV) has been suggested as a therapy for uveitis, with reports of reduced inflammation and decreased dependence on medication postoperatively. Currently, PPV is reserved for retinal detachments, vitreous opacities, and ERMs, causing vitreomacular traction...
May 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28080174/the-use-of-topical-non-steroidal-anti-inflammatory-drugs-for-uveitic-cystoid-macular-edema
#9
Harry Petrushkin, Duncan Rogers, Carlos Pavesio
The use of topical non-steroidal anti-inflammatory drugs in the management of uveitic cystoid macular edema is controversial. In this letter, we review the literature and report our results from a retrospective case series of 281 patients taking topical nepafenac 0.1% for uveitic cystoid macular edema between 2010 and 2016. Over a 4-month period, there was a modest improvement in best-corrected visual acuity (0.66 ± 3.7 logMAR) and central macular thickness (69.8 ± 132.5 μm). Patients with idiopathic anterior uveitis and HLA-B*27-associated anterior uveitis recovered more vision while taking topical nepafenac 0...
January 12, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28043984/cataract-surgery-in-uveitis-a-multicentre-database-study
#10
MULTICENTER STUDY
Colin J Chu, Andrew D Dick, Robert L Johnston, Yit C Yang, Alastair K Denniston
BACKGROUND/AIMS: Cataract is an important source of visual loss in patients with uveitis. Whether or not outcomes of cataract surgery in eyes with uveitis are worse compared with non-uveitic eyes have to date been compromised by lack of reliable estimates of benefit and harm, which require data from large cohorts. METHODS: Electronic medical record data were extracted from eight independent UK clinical sites for eyes undergoing cataract extraction between January 2010 and December 2014...
August 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27893624/prospective-evaluation-of-a-sustained-release-dexamethasone-intravitreal-implant-for-cystoid-macular-edema-in-quiescent-uveitis
#11
Rahul N Khurana, Alok S Bansal, Louis K Chang, James D Palmer, Chengqing Wu, Mark R Wieland
PURPOSE: To investigate dexamethasone intravitreal implant (DEX implant; OZURDEX, Allergan, Inc) in the treatment of uveitic cystoid macular edema that had persisted in the absence of intraocular inflammation. METHODS: In this prospective interventional case series, 10 patients with uveitic cystoid macular edema and quiescent uveitis were treated with dexamethasone intravitreal implant at baseline and evaluated monthly for one year. Patients were retreated whenever cystoid macular edema recurred...
November 23, 2016: Retina
https://www.readbyqxmd.com/read/27736275/iluvien-implantation-for-uveitis-and-uveitic-macular-edema
#12
Ashvini K Reddy, Bryn M Burkholder, Irfan R Khan, Jennifer E Thorne
No abstract text is available yet for this article.
October 13, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27630374/the-effect-of-different-dosing-schedules-of-intravitreal-sirolimus-a-mammalian-target-of-rapamycin-mtor-inhibitor-in-the-treatment-of-non-infectious-uveitis-an-american-ophthalmological-society-thesis
#13
RANDOMIZED CONTROLLED TRIAL
Quan Dong Nguyen, Mohammad Ali Sadiq, Mohamed Kamel Soliman, Aniruddha Agarwal, Diana V Do, Yasir J Sepah
PURPOSE: To determine if two different doses of intravitreal sirolimus, an mTOR inhibitor, can decrease inflammation and is safe in eyes with non-infectious posterior, intermediate, or panuveitis in the Sirolimus as a Therapeutic Approach UVEitis: Protocol-2 (SAVE-2) Study. METHODS: SAVE-2 is a prospective randomized, phase II, open-label interventional clinical trial conducted at 4 clinical centers in the United States. Eligible subjects were randomized into one of two treatments...
August 2016: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/27598822/phacoemulsification-with-intraocular-lens-implantation-in-pediatric-uveitis-a-retrospective-study
#14
Sudha K Ganesh, Saurabh Mistry
PURPOSE: To analyze the outcome of phacoemulsification with primary posterior chamber intraocular lens (IOL) implantation without primary posterior capsulorhexis in older children with uveitis. METHODS: Retrospective study of children with uveitis who underwent phacoemulsification with IOL implantation between January 2006 and May 2014. RESULTS: Twenty-one eyes of 16 children were included. Mean age at cataract surgery was 10.9 years. Juvenile idiopathic arthritis was associated in 37...
September 6, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27594138/quantifying-retinal-microvascular-changes-in-uveitis-using-spectral-domain-optical-coherence-tomography-angiography
#15
MULTICENTER STUDY
Alice Y Kim, Damien C Rodger, Anoush Shahidzadeh, Zhongdi Chu, Nicole Koulisis, Bruce Burkemper, Xuejuan Jiang, Kathryn L Pepple, Ruikang K Wang, Carmen A Puliafito, Narsing A Rao, Amir H Kashani
PURPOSE: To quantify retinal capillary density and morphology in uveitis using spectral-domain optical coherence tomography angiography (SD-OCTA). DESIGN: Cross-sectional, observational study. METHODS: Healthy and uveitic subjects were recruited from 2 tertiary care eye centers. Prototype SD-OCTA devices (Cirrus; Carl Zeiss Meditec, Inc, Dublin, California, USA) were used to generate 3 × 3-mm(2) OCTA images centered on the fovea. Subjects were placed into 3 groups based on the type of optical microangiography (OMAG) algorithm used for image processing (intensity and/or phase) and type of retinal segmentation (automatic or manual)...
November 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27529841/resolution-of-noninfectious-uveitic-cystoid-macular-edema-with-topical-difluprednate
#16
Daniel L Feiler, Sunil K Srivastava, Francesco Pichi, James Bena, Careen Y Lowder
PURPOSE: To evaluate the short-term safety and efficacy of topical difluprednate (0.05%) for the treatment of noninfectious uveitic cystoid macular edema. METHODS: Twenty-seven patients (35 eyes) undergoing treatment with difluprednate 4 times daily for 3 weeks for noninfectious uveitic cystoid macular edema were reviewed for visual acuity, intraocular pressure, optical coherence tomography, and fluorescein angiography results. A mixed model analysis was fit with each measure as the outcome, visit as the primary predictor, and patient and eye as random effects...
May 2017: Retina
https://www.readbyqxmd.com/read/27479780/response-of-postoperative-and-chronic-uveitic-cystoid-macular-edema-to-a-dexamethasone-based-intravitreal-implant-ozurdex
#17
Justus G Garweg, Edoardo Baglivo, Florentina J Freiberg, Maximilian Pfau, Isabel B Pfister, Stephan Michels, Souska Zandi
PURPOSE: To survey the clinical responses to treatment of chronic postoperative and uveitic cystoid macular edema (CME) with a dexamethasone-based intravitreal implant (Ozurdex(®)). METHODS: This retrospective, interventional case series reports on patients with chronic CME after uncomplicated vitrectomy for epiretinal gliosis or phacoemulsification (group 1: 12 eyes) or secondary to noninfectious endogenous uveitis (group 2: 36 eyes). Central retinal thickness (CRT), best-corrected visual acuity (BCVA, logMAR), and intraocular pressure (IOP) throughout follow-up were gleaned from the medical records...
September 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27391933/spectral-domain-optical-coherence-tomography-findings-of-the-macula-in-500-consecutive-patients-with-uveitis
#18
R S Grajewski, A C Boelke, W Adler, S Meyer, A Caramoy, B Kirchhof, C Cursiefen, L M Heindl
PurposeTo analyze the macular structure in a large series of consecutive patients with different types of uveitis using spectral-domain optical coherence tomography (SD-OCT).Patients and methodsFive hundred eyes of 500 consecutive patients with anterior, intermediate, posterior, and panuveitis underwent standardized macular examination using SD-OCT. Central retinal thickness (CRT), macular volume (MV), and presence of cystoid macular edema (CME), diffuse macular edema (DME), serous retinal detachment (SRD), epiretinal membrane with (ERM+) and without (ERM-) retinal surface wrinkling were determined...
November 2016: Eye
https://www.readbyqxmd.com/read/27347446/uveitic-macular-edema-treatment-update
#19
Raquel Goldhardt, Bradley Simon Rosen
The aim of this review is to summarize recent developments in the treatment of uveitic macular edema (ME). ME represent a major cause of visual loss in uveitis and adequate management is crucial for the maintenance of useful vision in patients with chronic uveitis.
March 2016: Current Ophthalmology Reports
https://www.readbyqxmd.com/read/27256304/uveitic-macular-edema
#20
REVIEW
C Fardeau, E Champion, N Massamba, P LeHoang
Macular edema (ME) may complicate anterior, intermediate, and posterior uveitis, which may be because of various infectious, neoplastic or autoimmune etiologies. BRB breakdown is involved in the pathogenesis of Uveitic ME (UME). Optical coherence tomography has become a standard tool to confirm the diagnosis of macular thickening, due to its non-invasive, reproducible, and sensitive features. Retinal fluorescein and indocyanine green angiography is helpful to study the macula and screen for associated vasculitis, detect ischemic areas and preretinal, prepapillary or choroidal neovascular complications, and it may provide information about the etiology and be needed to assess the therapeutic response...
October 2016: Eye
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