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https://www.readbyqxmd.com/read/29917268/kap1-inhibits-the-raf-mek-erk-pathway-to-promote-tumorigenesis-in-a549-lung-cancer-cells
#1
Guo-Jin Wu, Jun Pen, Ying Huang, Su An, Ying Liu, Yang Yang, Qian Hao, Xiao-Xi Guo, Tian-Rui Xu
Aberrant activation of the Raf-MEK-ERK pathway has frequently been associated with various cancers, especially lung cancer. However, the key regulators of this pathway are largely unknown. Using functional proteomics screening, we found that KAP1 interacts with c-Raf. Knocking out KAP1 decreased c-Raf phosphorylation at serine 259 and increased its phosphorylation at serine 338, which activated MEK and ERK. We detected higher KAP1 expression in lung cancer tissues than in normal peri-tumoral tissues. KAP1 knockdown arrested A549 lung cancer cells in the G0/G1 phase of the cell cycle and attenuated cell growth, metastasis, the epithelial-mesenchymal transition, angiogenesis, stemness, and colony formation...
June 19, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29915721/involvement-of-nadph-oxidase-1-in-liver-kinase-b1-mediated-effects-on-tumor-angiogenesis-and-growth
#2
Elisabetta Zulato, Francesco Ciccarese, Giorgia Nardo, Marica Pinazza, Valentina Agnusdei, Micol Silic-Benussi, Vincenzo Ciminale, Stefano Indraccolo
The liver kinase B1 ( LKB1 ) gene is a tumor suppressor with an established role in the control of cell metabolism and oxidative stress. However, whether dis-regulated oxidative stress promotes growth of LKB1-deficient tumors remains substantially unknown. Through in vitro studies, we observed that loss of LKB1 perturbed expression of several genes involved in reactive oxygen species (ROS) homeostasis. In particular, this analysis evidenced strongly up-modulated NADPH oxidase 1 ( NOX1 ) transcript levels in tumor cells lacking LKB1...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29915610/identification-and-characterization-of-an-arabidopsis-thaliana-mutant-lbt-with-high-tolerance-to-boron-deficiency
#3
Zexun Huai, Lishun Peng, Sheliang Wang, Hua Zhao, Lei Shi, Fangsen Xu
Boron (B) is an essential micronutrient of plants. In the present study, we characterized an Arabidopsis mutant lbt with significant l ow -b oron t olerance that was identified based on our previous mapping of QTL for B efficiency in Arabidopsis . Multiple nutrient-deficiency analyses point out that lbt mutant is insensitive to only B-limitation stress. Compared with wild-type Col-0, the fresh weight, leaf area, root length and root elongation rate of lbt mutant were significantly improved under B deficiency during vegetative growth...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29915110/nitrogenase-activity-oxygen-exposure-and-hydrogen-production-by-azotobacter-vinelandii
#4
Jace Natzke, Jesse Noar, José M Bruno-Bárcena
Azotobacter vinelandii selectively utilizes three types of nitrogenase (molybdenum, vanadium, and iron-only) to fix N2 with their expression regulated by the presence or absence of different metal cofactors in its environment. Each alternative nitrogenase isoenzyme is predicted to have different electron flux requirements based off in vitro measurements, with the molybdenum nitrogenase requiring the lowest flux and the iron-only nitrogenase requiring the highest. Here, prior characterized strains, de-repressed in nitrogenase synthesis and also deficient in uptake hydrogenase, were further modified to generate new mutants lacking the ability to produce poly-β-hydroxybutyrate (PHB)...
June 18, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29914387/a-de-novo-kmt2d-mutation-in-a-girl-with-kabuki-syndrome-associated-with-endocrine-symptoms-a-case-report
#5
Jung-Eun Moon, Su-Jeong Lee, Cheol Woo Ko
BACKGROUND: Kabuki syndrome is characterized by distinctive facial features and varying degrees of growth retardation. It leads to malformations in skeletal, urogenital and cardiac structures; moreover, endocrine conditions such as premature thelarche, precocious puberty, growth hormone deficiency, diabetes insipidus, thyroid dysfunction and obesity have been reported. Kabuki syndrome is caused by a heterozygous mutation in the KMT2D or KDM6A genes. CASE PRESENTATION: An 11-year-old girl with the typical facial features of Kabuki syndrome visited our hospital due to her short stature...
June 18, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29913483/the-associations-between-the-growth-hormone-insulin-like-growth-factor-1-axis-adiponectin-resistin-and-metabolic-profile-in-children-with-growth-hormone-deficiency-before-and-during-growth-hormone-treatment
#6
Ewelina Witkowska-Sędek, Małgorzata Rumińska, Anna Stelmaszczyk-Emmel, Anna Majcher, Beata Pyrżak
This study investigated associations between the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis, adiponectin, resistin and metabolic profile in 47 GH-deficient children before and during 12 months of GH treatment. 23 short age-matched children without growth hormone deficiency (GHD) or any genetic or chronic disorders were recruited as controls at baseline. Metabolic evaluation included measurements of adiponectin, resistin, IGF-1, total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), glucose, insulin, glycated haemoglobin (HbA1c), thyroid stimulating hormone (TSH) and free thyroxine (free T4) concentrations...
2018: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29913266/the-mechanism-of-iron-compensation-for-manganese-deficiency-of-streptococcus-pneumoniae
#7
Kun Cao, Fubin Lai, Xin-Lu Zhao, Qiu-Xia Wei, Xin-Yu Miao, Ruiguang Ge, Qing-Yu He, Xuesong Sun
Given their involvement in catalysis, infection, and biofilm formation, Fe and Mn are essential for bacterial survival and virulence. In this study, we found that Streptococcus pneumoniae (S. pneumoniae) could grow in the Mn-deficient medium (MDCM). Furthermore, findings showed that the Fe concentration in the bacterium increased when the Mn concentration decreased. In addition, it was noted that supplementing MDCM with Fe resulted in the recovery of bacterial growth. Quantitative proteomics using stable-isotope dimethyl labeling was performed to investigate the adaptive growth mechanism of S...
June 15, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29911270/nano-delivery-of-trace-minerals-for-marine-fish-larvae-influence-on-skeletal-ossification-and-the-expression-of-genes-involved-in-intestinal-transport-of-minerals-osteoblast-differentiation-and-oxidative-stress-response
#8
Genciana Terova, Simona Rimoldi, Marisol Izquierdo, Cristina Pirrone, Wafa Ghrab, Giovanni Bernardini
Currently, the larviculture of many marine fish species with small-sized larvae depends for a short time after hatching, on the supply of high-quality live zooplankton to ensure high survival and growth rates. During the last few decades, the research community has made great efforts to develop artificial diets, which can completely substitute live prey. However, studies aimed at determining optimal levels of minerals in marine larvae compound feeds and the potential of novel delivery vectors for mineral acquisition has only very recently begun...
June 17, 2018: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29911200/investigating-the-consequences-of-asymmetric-endoplasmic-reticulum-inheritance-in-saccharomyces-cerevisiae-under-stress-using-a-combination-of-single-cell-measurements-and-mathematical-modelling
#9
Felix R H Jonas, Kate E Royle, Rochelle Aw, Guy-Bart V Stan, Karen M Polizzi
Adaptation allows organisms to maintain a constant internal environment, which is optimised for growth. The unfolded protein response (UPR) is an example of a feedback loop that maintains endoplasmic reticulum (ER) homeostasis, and is characteristic of how adaptation is often mediated by transcriptional networks. The more recent discovery of asymmetric division in maintaining ER homeostasis, however, is an example of how alternative non-transcriptional pathways can exist, but are overlooked by gold standard transcriptomic or proteomic population-based assays...
March 2018: Synthetic and Systems Biotechnology
https://www.readbyqxmd.com/read/29911066/the-evaluation-and-clinical-efficiency-of-power-scope-an-original-research
#10
Tony Antony, Vivek Amin, Shourya Hegde, Shreya Hegde, Deepa Shetty, Mohammadi Begum Khan
Aims and Objectives: Managing mild-to-moderate Class II malocclusion is one of the common and major challenges to orthodontists. Class II discrepancies with mandibular deficiency during active growth are usually treated using myofunctional appliances. Fixed functional appliances evolved due to the noncompliance with conventional myofunctional appliances. One of the latest Class II correctors is the PowerScope appliance. The purpose of this study was to determine the amount, time, and rate of molar correction and efficacy of PowerScope...
May 2018: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/29911034/fetal-skeletal-size-and-growth-are-relevant-biometric-markers-in-vitamin-d-deficient-mothers-a-north-east-india-prospective-cohort-study
#11
Dipti Sarma, Uma K Saikia, Darvin V Das
Context: The neonatal skeletal outcomes due to maternal Vitamin D deficiency. Aims: The aim of this study is to assess the serum 25 hydroxy Vitamin D (25[OH]D) status in pregnant women and correlate with cord blood 25(OH)D levels, femur length at 34 weeks gestation, and neonatal anthropometry (birth weight, birth length, and head circumference). Settings and Design: This was prospective cohort study. Subjects and Methods: This study was carried out in 250 healthy primigravida between 18 and 40 years of age in the third trimester of gestation attending the Obstetrics and Gynaecology Department of Gauhati Medical College, Guwahati from December 2012 to December 2015...
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29910978/cortical-bone-adaptation-and-mineral-mobilization-in-the-subterranean-mammal-bathyergus-suillus-rodentia-bathyergidae-effects-of-age-and-sex
#12
Germán Montoya-Sanhueza, Anusuya Chinsamy
The patterns of bone modeling and mineral mobilization (skeletal homeostasis) among mammals other than humans and laboratory rodents are still poorly known. In this study we assessed the pattern of bone formation and bone resorption in the femur of a wild population of Cape dune molerats, Bathyergus suillus ( n = 41) (Bathyergidae), a solitary subterranean mammal with a marked extended longevity among rodents, and which also lives in a naturally deficient state of vitamin D. In order to determine ontogenetic and sex effects on histomorphometric parameters of transversal undecalcified bone sections, two-way ANOVA, linear mixed-effects model and regression statistical analyses were performed...
2018: PeerJ
https://www.readbyqxmd.com/read/29910815/-toxoplasma-chinese-1-strain-of-wh3%C3%AE-rop16-i-iii-gra15-ii-genetic-background-contributes-to-abnormal-pregnant-outcomes-in-murine-model
#13
Cong Wang, Weisheng Cheng, Qian Yu, Tian Xing, Shoubin Chen, Lei Liu, Li Yu, Jian Du, Qingli Luo, Jilong Shen, Yuanhong Xu
Toxoplasma gondii infection evokes a strong Th1-type response with interleukin (IL)-12 and interferon (IFN)-γ secretion. Recent studies suggest that the infection of pregnant mice with T. gondii may lead to adverse pregnancy results caused by subversion of physiological immune tolerance at maternofetal interface rather than direct invasion of the parasite. Genotype-associated dense granule protein GRA15II tends to induce classically activated macrophage (M1) differentiation and subsequently activating NK, Th1, and Th17 cells whereas rhoptry protein ROP16I/III drives macrophages to alternatively activated macrophage (M2) polarization and elicits Th2 immune response...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29910787/understanding-the-strategies-to-overcome-phosphorus-deficiency-and-aluminum-toxicity-by-ryegrass-endophytic-and-rhizosphere-phosphobacteria
#14
Patricio J Barra, Sharon Viscardi, Milko A Jorquera, Paola A Duran, Alexander J Valentine, María de la Luz Mora
Phosphobacteria, secreting organic acids and phosphatases, usually favor plant performance in acidic soils by increasing phosphorus (P) availability and aluminum (Al) complexing. However, it is not well-known how P-deficiency and Al-toxicity affect the phosphobacteria physiology. Since P and Al problems often co-occur in acidic soils, we have therefore proposed the evaluation of the single and combined effects of P-deficiency and Al-toxicity on growth, organic acids secretion, malate dehydrogenase ( mdh ) gene expression, and phosphatase activity of five Al-tolerant phosphobacteria previously isolated from ryegrass...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29910227/postoperative-growth-hormone-dynamics-in-clinically-nonfunctioning-pituitary-adenoma
#15
Nobuyuki Kobayashi, Mitsuo Yamaguchi-Okada, Kentaro Horiguchi, Noriaki Fukuhara, Hiroshi Nishioka, Shozo Yamada
Growth hormone deficiency (GHD) is an endocrine disorder characterized by insufficient production of growth hormone (GH). Non-functioning pituitary adenoma (NFPA) is one of common causes of GHD. Although most patients with NFPA have transsphenoidal surgery, the time-dependent changes in GH after operation have yet to be investigated. In this study, we analyzed patients with NFPAs that underwent transsphenoidal surgery. Postoperatively, GH secretion was evaluated in response to GH-releasing peptide-2 (GHRP2) infusion...
June 15, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29909504/anderson-fabry-disease-in-heart-failure
#16
REVIEW
M M Akhtar, P M Elliott
Anderson-Fabry disease is an X-linked lysosomal storage disorder caused by mutations in the GLA gene that result in deficiency of the enzyme alpha-galactosidase A. The worldwide incidence of Fabry's disease is reported to be in the range of 1 in 40,000-117,000, although this value may be a significant underestimate given under recognition of symptoms and delayed or missed diagnosis. Deficiency in alpha-galactosidase A causes an accumulation of neutral glycosphingolipids such as globotriaosylceramide (Gb3) in lysosomes within various tissues including the vascular endothelium, kidneys, heart, eyes, skin and nervous system...
June 16, 2018: Biophysical Reviews
https://www.readbyqxmd.com/read/29908648/maternal-perceived-stress-during-pregnancy-increases-risk-for-low-neonatal-iron-at-delivery-and-depletion-of-storage-iron-at-one-year
#17
Danielle N Rendina, Sharon E Blohowiak, Christopher L Coe, Pamela J Kling
OBJECTIVE: To investigate the impact of maternal stress during pregnancy on newborn iron and stage 1 iron deficiency at 1 year of age. STUDY DESIGN: In total, 245 mothers and their newborn infants (52% male; 72% white) were recruited at the Meriter Hospital Birthing Center on the basis of known risk factors for iron deficiency. Umbilical cord blood hemoglobin and zinc protoporphyrin/heme (ZnPP/H) were determined to evaluate erythrocyte iron and plasma ferritin was determined to reflect storage iron...
June 14, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29907984/tls-dependent-and-independent-functions-of-dna-polymerase-eta-pol%C3%AE-rad30-from-pathogenic-yeast-candida-albicans
#18
Kodavati Manohar, Doureradjou Peroumal, Narottam Acharya
Polη, a unique TLS DNA polymerase that promotes efficient bypass of UV-induced CPDs and cisplatin adducts, has not been explored in Candida species yet. Here we show that CaPolη plays a vital role in protecting Candida albicans genome from diverse array of DNA damaging agents, not limited to UV and cisplatin. Polη deficient strain did not exhibit any hyphal development in the presence of UV and cisplatin while the wild type strain profusely developed DNA damage induced filamentation. The polarized growth induced by HU and MMS was found to be Polη independent...
June 15, 2018: Molecular Microbiology
https://www.readbyqxmd.com/read/29907586/yap-is-essential-for-treg-mediated-suppression-of-anti-tumor-immunity
#19
Xuhao Ni, Jinhui Tao, Joseph Barbi, Qian Chen, Benjamin V Park, Zhiguang Li, Nailing Zhang, Andriana Lebid, Anjali Ramaswamy, Ping Wei, Ying Zheng, Xuehong Zhang, Xingmei Wu, Paolo D A Vignali, Cuiping Yang, Huabin Li, Drew Pardoll, Ling Lu, Duojia Pan, Fan Pan
Regulatory T cells (Tregs) are critical for maintaining self-tolerance and immune homeostasis, but their suppressive function can impede effective anti-tumor immune responses. Foxp3 is a transcription factor expressed in Tregs that is required for their function. However, the pathways and microenvironmental cues governing Foxp3 expression and Treg function are not completely understood. Herein, we report that Yes-associated protein (YAP), a co-activator of the Hippo pathway, is highly expressed in Tregs and bolsters Foxp3 expression and Treg function in vitro and in vivo...
June 15, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29907119/efficient-production-of-1-3-propanediol-from-crude-glycerol-by-repeated-fed-batch-fermentation-strategy-of-a-lactate-and-2-3-butanediol-deficient-mutant-of-klebsiella-pneumoniae
#20
Baek-Rock Oh, Sung-Mok Lee, Sun-Yeon Heo, Jeong-Woo Seo, Chul Ho Kim
BACKGROUND: 1,3-Propanediol (1,3-PDO) is important building blocks for the bio-based chemical industry, Klebsiella pneumoniae can be an attractive candidate for their production. However, 1,3-PDO production is high but productivity is generally low by K. pneumoniae. In this study, repeated fed-batch cultivation by a lactate and 2,3-butanediol (2,3-BDO) deficient mutant of K. pneumoniae were investigated for efficient 1,3-PDO production from industrial by-products such as crude glycerol...
June 15, 2018: Microbial Cell Factories
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