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depression & inflammation & cancer

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https://www.readbyqxmd.com/read/28546059/inflammation-and-attentional-bias-in-breast-cancer-survivors
#1
Chloe C Boyle, Patricia A Ganz, Kathleen M Van Dyk, Julienne E Bower
Evidence suggests an association between inflammation and depression, although findings are mixed. Focusing on core processes in depression may clarify associated biological underpinnings. Negative cognitive bias is a key component of depression, but has not been examined in relation to inflammation. Thus, we tested the hypothesis that elevated inflammatory markers would be associated with negative attentional bias in a sample of 91 breast cancer survivors. Participants were drawn from a larger study and provided blood samples for assessment of peripheral markers of inflammation and completed questionnaires and neuropsychological testing...
May 22, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28528242/efficacy-and-safety-of-celecoxib-monotherapy-for-mild-to-moderate-depression-in-patients-with-colorectal-cancer-a-randomized-double-blind-placebo-controlled-trial
#2
Maryam Alamdarsaravi, Alireza Ghajar, Ahmad-Ali Noorbala, Mohammad Arbabi, Amirhossein Emami, Farhad Shahei, Mehrzad Mirzania, Morteza Jafarinia, Mohsen Afarideh, Shahin Akhondzadeh
Cancer-related inflammation is an essential process in malignancies. Celecoxib, a nonsteroidal anti-inflammatory drug that acts via the selective inhibition of cyclooxygenase (COX)-2, has shown favorable effects in several psychiatric disorders. The present study aimed to assess the safety and efficacy of celecoxib single therapy on depressive symptoms of patients with colorectal cancer who underwent chemotherapy. The study was conducted as a 6-week, parallel-group, randomized, double-blind, placebo-controlled trial...
May 17, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28508317/trpc-channels-and-brain-inflammation
#3
Yoshito Mizoguchi, Akira Monji
Nonresolving low-grade inflammation is supposed to underly the basis of chronic disorders including cardiovascular diseases, cancer, diabetes, obesity, and psychiatric disorders such as depression and Alzheimer's diseases. There is increasing evidence suggesting that pathophysiology of psychiatric disorders is related to the inflammatory responses mediated by microglial cells. Elevation of intracellular Ca(2+) is important for the activation of microglial cell functions, including proliferation, release of NO, cytokines, and BDNF...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28479263/novel-rodent-model-of-breast-cancer-survival-with-persistent-anxiety-like-behavior-and-inflammation
#4
Leah M Pyter, Lorena P Suarez-Kelly, William E Carson, Jasskiran Kaur, Joshua Bellisario, Savannah R Bever
Breast cancer survivors are an expanding population that is troubled by lasting mental health problems, including depression and anxiety. These issues reduce quality-of-life throughout survivorhood. Research indicates that tumor biology, cancer treatments, and stress contribute to these mood disturbances. Although the mechanisms underlying these various causes remain under investigation, neuroinflammation is a leading hypothesis. To date, rodent models of recurrence-free tumor survival for understanding mechanisms by which these behavioral issues persist after cancer are lacking...
May 4, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28412530/indoles-as-therapeutics-of-interest-in-medicinal-chemistry-bird-s-eye-view
#5
REVIEW
Navriti Chadha, Om Silakari
Indoles constitute extensively explored heterocyclic ring systems with wide range of applications in pathophysiological conditions that is, cancer, microbial and viral infections, inflammation, depression, migraine, emesis, hypertension, etc. Presence of indole nucleus in amino acid tryptophan makes it prominent in phytoconstituents such as perfumes, neurotransmitters, auxins (plant hormones), indole alkaloids etc. The interesting molecular architecture of indole makes them suitable candidates for the drug development...
April 5, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28408965/phospholipase-c-related-catalytically-inactive-protein-can-regulate-obesity-a-state-of-peripheral-inflammation
#6
REVIEW
Yosuke Yamawaki, Kana Oue, Satomi Shirawachi, Satoshi Asano, Kae Harada, Takashi Kanematsu
Obesity is defined as abnormal or excessive fat accumulation. Chronic inflammation in fat influences the development of obesity-related diseases. Many reports state that obesity increases the risk of morbidity in many diseases, including hypertension, dyslipidemia, type 2 diabetes, coronary heart disease, stroke, sleep apnea, and breast, prostate and colon cancers, leading to increased mortality. Obesity is also associated with chronic neuropathologic conditions such as depression and Alzheimer's disease. However, there is strong evidence that weight loss reduces these risks, by limiting blood pressure and improving levels of serum triglycerides, total cholesterol, low-density lipoprotein (LDL)-cholesterol, and high-density lipoprotein (HDL)-cholesterol...
February 2017: Japanese Dental Science Review
https://www.readbyqxmd.com/read/28399592/comparative-metabolism-study-of-five-protoberberine-alkaloids-in-liver-microsomes-from-rat-rhesus-monkey-and-human
#7
Yan Li, Yanyan Zhou, Nan Si, Lingyu Han, Wei Ren, Shaokun Xin, Hongjie Wang, Ran Zuo, Xiaolu Wei, Jian Yang, Haiyu Zhao, Baolin Bian
Protoberberine alkaloids including berberine, palmatine, jatrorrhizine, coptisine, and epiberberine are major components in many medicinal plants. They have been widely used for the treatment of cancer, inflammation, diabetes, depression, hypertension, and various infectious areas. However, the metabolism of five protoberberine alkaloids among different species has not been clarified previously. In order to elaborate on the in vitro metabolism of them, a comparative analysis of their metabolic profile in rat, rhesus monkey, and human liver microsomes was carried out using ultrahigh-performance liquid chromatography coupled with a high-resolution linear trap quadrupole-Orbitrap mass spectrometer (UHPLC-electrospray ionization-Orbitrap MS) for the first time...
April 11, 2017: Planta Medica
https://www.readbyqxmd.com/read/28382827/cognitive-behaviour-therapy-and-inflammation-a-systematic-review-of-its-relationship-and-the-potential-implications-for-the-treatment-of-depression
#8
Adrian L Lopresti
OBJECTIVE: There is growing evidence confirming increased inflammation in a subset of adults with depression. The impact of this relationship has mostly been considered in biologically based interventions; however, it also has potential implications for psychological therapies. Cognitive behaviour therapy is the most commonly used psychological intervention for the treatment of depression with theories around its efficacy primarily based on psychological mechanisms. However, cognitive behaviour therapy may have an effect on, and its efficacy influenced by, physiological processes associated with depression...
April 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28193310/depressive-symptoms-and-inflammation-are-independent-risk-factors-of-fatigue-in-breast-cancer-survivors
#9
C Xiao, A H Miller, J Felger, D Mister, T Liu, M A Torres
BACKGROUND: Psychosocial and inflammatory factors have been associated with fatigue in breast cancer survivors. Nevertheless, the relative contribution and/or interaction of these factors with cancer-related fatigue have not been well documented. METHOD: This cross-sectional study enrolled 111 stage 0-III breast cancer patients treated with breast surgery followed by whole breast radiotherapy. Fatigue was measured by the total score of the Multidimensional Fatigue Inventory-20...
February 14, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28192452/increased-risk-of-dementia-in-patients-hospitalized-with-acute-kidney-injury-a-nationwide-population-based-cohort-study
#10
Hsin-Hsi Tsai, Ruoh-Fang Yen, Cheng-Li Lin, Chia-Hung Kao
PURPOSE: To determine whether acute kidney injury (AKI) is a risk factor for dementia. METHODS: This nationwide population-based cohort study was based on data from the Taiwan National Health Insurance Research Database for 2000-2011. The incidence and relative risk of dementia were assessed in 207788 patients hospitalized for AKI. The comparison control was selected using the propensity score based on age, sex, index year and comorbidities. RESULTS: During the 12-year follow-up, patients with AKI had a significantly higher incidence for developing dementia than did the controls (8...
2017: PloS One
https://www.readbyqxmd.com/read/28147298/microrna-135a-is-up-regulated-and-aggravates-myocardial-depression-in-sepsis-via-regulating-p38-mapk-nf-%C3%AE%C2%BAb-pathway
#11
Ge Zheng, Minli Pan, Weimin Jin, Guoxin Jin, Yumao Huang
MicroRNA-135a (miR-135a) is implicated in the pathological processes of several cancers. However, the roles and regulatory mechanism of miR-135a in sepsis-induced myocardial depression (MD) remain largely unknown. In this study, the serum of patients with sepsis and healthy controls was obtained. The miR-135a expression was then measured. Then lentiviruses (miR-135a mimic, inhibitor and scramble control) were transfected into BALB/c mice. After 4days of transfection, polymicrobial sepsis model was established by cecal ligation and puncture (CLP) surgery...
April 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/27933449/clearing-the-fog-a-review-of-the-effects-of-dietary-omega-3-fatty-acids-and-added-sugars-on-chemotherapy-induced-cognitive-deficits
#12
REVIEW
Tonya S Orchard, Monica M Gaudier-Diaz, Kellie R Weinhold, A Courtney DeVries
Cancer treatments such as chemotherapy have been an important part of extending survival in women diagnosed with breast cancer. However, chemotherapy can cause potentially toxic side effects in the brain that impair memory, verbal fluency, and processing speed in up to 30% of women treated. Women report that post-chemotherapy cognitive deficits negatively impact quality of life and may last up to ten years after treatment. Mechanisms underlying these cognitive impairments are not fully understood, but emerging evidence suggests that chemotherapy induces structural changes in the brain, produces neuroinflammation, and reduces adult hippocampal neurogenesis...
February 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27894012/depression-in-cancer-the-many-biobehavioral-pathways-driving-tumor-progression
#13
REVIEW
Beatrice Bortolato, Thomas N Hyphantis, Sara Valpione, Giulia Perini, Michael Maes, Gerwyn Morris, Marta Kubera, Cristiano A Köhler, Brisa S Fernandes, Brendon Stubbs, Nicholas Pavlidis, André F Carvalho
Major Depressive Disorder (MDD) is common among cancer patients, with prevalence rates up to four-times higher than the general population. Depression confers worse outcomes, including non-adherence to treatment and increased mortality in the oncology setting. Advances in the understanding of neurobiological underpinnings of depression have revealed shared biobehavioral mechanisms may contribute to cancer progression. Moreover, psychosocial stressors in cancer promote: (1) inflammation and oxidative/nitrosative stress; (2) a decreased immunosurveillance; and (3) a dysfunctional activation of the autonomic nervous system and of the hypothalamic-pituitaryadrenal axis...
January 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/27886849/prevalence-and-burden-of-comorbidities-in-chronic-obstructive-pulmonary-disease
#14
REVIEW
Alexandru Corlateanu, Serghei Covantev, Alexander G Mathioudakis, Victor Botnaru, Nikolaos Siafakas
The classical definition of Chronic Obstructive Pulmonary Disease (COPD) as a lung condition characterized by irreversible airway obstruction is outdated. The systemic involvement in patients with COPD, as well as the interactions between COPD and its comorbidities, justify the description of chronic systemic inflammatory syndrome. The pathogenesis of COPD is closely linked with aging, as well as with cardiovascular, endocrine, musculoskeletal, renal, and gastrointestinal pathologies, decreasing the quality of life of patients with COPD and, furthermore, complicating the management of the disease...
November 2016: Respiratory Investigation
https://www.readbyqxmd.com/read/27881072/patients-with-longstanding-ulcerative-colitis-in-remission-do-not-have-more-irritable-bowel-syndrome-like-symptoms-than-controls
#15
D Lundgren, J Rutegård, V Eklöf, R Palmqvist, P Karling
BACKGROUND: Irritable bowel syndrome (IBS) is more common in patients with ulcerative colitis (UC) than expected. The prevalence of IBS in patients with UC with longstanding disease is not known. We investigated the prevalence of IBS-like symptoms in patients with UC in remission and longstanding disease in comparison to control subjects. METHODS: Sixty-eight patients with UC and 33 patients with hereditary familiar colon cancer and who underwent colonoscopy surveillance were included...
November 24, 2016: BMC Gastroenterology
https://www.readbyqxmd.com/read/27862626/pro-and-anti-inflammatory-cytokine-associations-with-major-depression-in-cancer-patients
#16
Madeline Li, Ekaterina Kouzmina, Megan McCusker, Danielle Rodin, Paul C Boutros, Christopher J Paige, Gary Rodin
OBJECTIVE: Cytokines may be linked to depression, although it has been challenging to demonstrate this association in cancer because of the overlap between depressive symptoms and other sickness behaviors. This study investigates the relationship between cytokines and depression in cancer patients, accounting for confounding clinical and methodological factors. METHODS: The GRID Hamilton Rating Scale for Depression and Neurotoxicity Rating Scale (NRS) for cytokine-induced sickness behaviors were administered to 61 cancer patients and 38 healthy controls...
November 15, 2016: Psycho-oncology
https://www.readbyqxmd.com/read/27857691/chemotherapy-induced-constipation-and-diarrhea-pathophysiology-current-and-emerging-treatments
#17
REVIEW
Rachel M McQuade, Vanesa Stojanovska, Raquel Abalo, Joel C Bornstein, Kulmira Nurgali
Gastrointestinal (GI) side-effects of chemotherapy are a debilitating and often overlooked clinical hurdle in cancer management. Chemotherapy-induced constipation (CIC) and Diarrhea (CID) present a constant challenge in the efficient and tolerable treatment of cancer and are amongst the primary contributors to dose reductions, delays and cessation of treatment. Although prevalence of CIC is hard to estimate, it is believed to affect approximately 16% of cancer patients, whilst incidence of CID has been estimated to be as high as 80%...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27784343/patterns-of-association-of-chronic-medical-conditions-and-major-depression
#18
S B Patten, J V A Williams, D H Lavorato, J L Wang, N Jetté, T T Sajobi, K M Fiest, A G M Bulloch
AIMS: Age and sex-related patterns of association between medical conditions and major depressive episodes (MDE) are important for understanding disease burden, anticipating clinical needs and for formulating etiological hypotheses. General population estimates are especially valuable because they are not distorted by help-seeking behaviours. However, even large population surveys often deliver inadequate precision to adequately describe such patterns. In this study, data from a set of national surveys were pooled to increase precision, supporting more precise characterisation of these associations...
October 27, 2016: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/27708244/hypoxia-pathway-and-hypoxia-mediated-extensive-extramedullary-hematopoiesis-are-involved-in-ursolic-acid-s-anti-metastatic-effect-in-4t1-tumor-bearing-mice
#19
Jian-Li Gao, Yan-Mei Shui, Wei Jiang, En-Yi Huang, Qi-Yang Shou, Xin Ji, Bai-Cheng He, Gui-Yuan Lv, Tong-Chuan He
Hypoxic in the tumor mass is leading to the myeloproliferative-like disease (leukemoid reaction) and anemia of body, which characterized by strong extensive extramedullary hematopoiesis (EMH) in spleen. As the key transcription factor of hypoxia, hypoxia-inducible factor-1 (HIF-1) activates the expression of genes essential for EMH processes including enhanced blood cell production and angiogenesis. We found ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, inhibited growth of breast cancer both in vivo and in vitro...
November 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27646264/depression-daily-stressors-and-inflammatory-responses-to-high-fat-meals-when-stress-overrides-healthier-food-choices
#20
J K Kiecolt-Glaser, C P Fagundes, R Andridge, J Peng, W B Malarkey, D Habash, M A Belury
Depression, stress and diet can all alter inflammation. This double-blind, randomized crossover study addressed the impact of daily stressors and a history of major depressive disorder (MDD) on inflammatory responses to high-fat meals. During two separate 9.5 h admissions, 58 healthy women (38 breast cancer survivors and 20 demographically similar controls), mean age 53.1 years, received either a high saturated fat meal or a high oleic sunflower oil meal. The Daily Inventory of Stressful Events assessed prior day stressors and the Structured Clinical Interview for DSM-IV evaluated MDD...
March 2017: Molecular Psychiatry
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