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depression & inflammation & cancer

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https://www.readbyqxmd.com/read/27894012/depression-in-cancer-the-many-biobehavioral-pathways-driving-tumor-progression
#1
REVIEW
Beatrice Bortolato, Thomas N Hyphantis, Sara Valpione, Giulia Perini, Michael Maes, Gerwyn Morris, Marta Kubera, Cristiano A Köhler, Brisa S Fernandes, Brendon Stubbs, Nicholas Pavlidis, André F Carvalho
Major Depressive Disorder (MDD) is common among cancer patients, with prevalence rates up to four-times higher than the general population. Depression confers worse outcomes, including non-adherence to treatment and increased mortality in the oncology setting. Advances in the understanding of neurobiological underpinnings of depression have revealed shared biobehavioral mechanisms may contribute to cancer progression. Moreover, psychosocial stressors in cancer promote: (1) inflammation and oxidative/nitrosative stress; (2) a decreased immunosurveillance; and (3) a dysfunctional activation of the autonomic nervous system and of the hypothalamic-pituitaryadrenal axis...
November 16, 2016: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/27886849/prevalence-and-burden-of-comorbidities-in-chronic-obstructive-pulmonary-disease
#2
REVIEW
Alexandru Corlateanu, Serghei Covantev, Alexander G Mathioudakis, Victor Botnaru, Nikolaos Siafakas
The classical definition of Chronic Obstructive Pulmonary Disease (COPD) as a lung condition characterized by irreversible airway obstruction is outdated. The systemic involvement in patients with COPD, as well as the interactions between COPD and its comorbidities, justify the description of chronic systemic inflammatory syndrome. The pathogenesis of COPD is closely linked with aging, as well as with cardiovascular, endocrine, musculoskeletal, renal, and gastrointestinal pathologies, decreasing the quality of life of patients with COPD and, furthermore, complicating the management of the disease...
November 2016: Respiratory Investigation
https://www.readbyqxmd.com/read/27881072/patients-with-longstanding-ulcerative-colitis-in-remission-do-not-have-more-irritable-bowel-syndrome-like-symptoms-than-controls
#3
D Lundgren, J Rutegård, V Eklöf, R Palmqvist, P Karling
BACKGROUND: Irritable bowel syndrome (IBS) is more common in patients with ulcerative colitis (UC) than expected. The prevalence of IBS in patients with UC with longstanding disease is not known. We investigated the prevalence of IBS-like symptoms in patients with UC in remission and longstanding disease in comparison to control subjects. METHODS: Sixty-eight patients with UC and 33 patients with hereditary familiar colon cancer and who underwent colonoscopy surveillance were included...
November 24, 2016: BMC Gastroenterology
https://www.readbyqxmd.com/read/27862626/pro-and-anti-inflammatory-cytokine-associations-with-major-depression-in-cancer-patients
#4
Madeline Li, Ekaterina Kouzmina, Megan McCusker, Danielle Rodin, Paul C Boutros, Christopher J Paige, Gary Rodin
OBJECTIVE: Cytokines may be linked to depression, although it has been challenging to demonstrate this association in cancer because of the overlap between depressive symptoms and other sickness behaviours. This study investigates the relationship between cytokines and depression in cancer patients, accounting for confounding clinical and methodological factors. METHODS: The GRID Hamilton Rating Scale for Depression (Ham-D) and Neurotoxicity Rating Scale (NRS) for cytokine-induced sickness behaviours were administered to 61 cancer patients, and 38 healthy controls...
November 15, 2016: Psycho-oncology
https://www.readbyqxmd.com/read/27857691/chemotherapy-induced-constipation-and-diarrhea-pathophysiology-current-and-emerging-treatments
#5
REVIEW
Rachel M McQuade, Vanesa Stojanovska, Raquel Abalo, Joel C Bornstein, Kulmira Nurgali
Gastrointestinal (GI) side-effects of chemotherapy are a debilitating and often overlooked clinical hurdle in cancer management. Chemotherapy-induced constipation (CIC) and Diarrhea (CID) present a constant challenge in the efficient and tolerable treatment of cancer and are amongst the primary contributors to dose reductions, delays and cessation of treatment. Although prevalence of CIC is hard to estimate, it is believed to affect approximately 16% of cancer patients, whilst incidence of CID has been estimated to be as high as 80%...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27784343/patterns-of-association-of-chronic-medical-conditions-and-major-depression
#6
S B Patten, J V A Williams, D H Lavorato, J L Wang, N Jetté, T T Sajobi, K M Fiest, A G M Bulloch
AIMS: Age and sex-related patterns of association between medical conditions and major depressive episodes (MDE) are important for understanding disease burden, anticipating clinical needs and for formulating etiological hypotheses. General population estimates are especially valuable because they are not distorted by help-seeking behaviours. However, even large population surveys often deliver inadequate precision to adequately describe such patterns. In this study, data from a set of national surveys were pooled to increase precision, supporting more precise characterisation of these associations...
October 27, 2016: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/27708244/hypoxia-pathway-and-hypoxia-mediated-extensive-extramedullary-hematopoiesis-are-involved-in-ursolic-acid-s-anti-metastatic-effect-in-4t1-tumor-bearing-mice
#7
Jian-Li Gao, Yan-Mei Shui, Wei Jiang, En-Yi Huang, Qi-Yang Shou, Xin Ji, Bai-Cheng He, Gui-Yuan Lv, Tong-Chuan He
Hypoxic in the tumor mass is leading to the myeloproliferative-like disease (leukemoid reaction) and anemia of body, which characterized by strong extensive extramedullary hematopoiesis (EMH) in spleen. As the key transcription factor of hypoxia, hypoxia-inducible factor-1 (HIF-1) activates the expression of genes essential for EMH processes including enhanced blood cell production and angiogenesis. We found ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, inhibited growth of breast cancer both in vivo and in vitro...
September 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27646264/depression-daily-stressors-and-inflammatory-responses-to-high-fat-meals-when-stress-overrides-healthier-food-choices
#8
J K Kiecolt-Glaser, C P Fagundes, R Andridge, J Peng, W B Malarkey, D Habash, M A Belury
Depression, stress and diet can all alter inflammation. This double-blind, randomized crossover study addressed the impact of daily stressors and a history of major depressive disorder (MDD) on inflammatory responses to high-fat meals. During two separate 9.5 h admissions, 58 healthy women (38 breast cancer survivors and 20 demographically similar controls), mean age 53.1 years, received either a high saturated fat meal or a high oleic sunflower oil meal. The Daily Inventory of Stressful Events assessed prior day stressors and the Structured Clinical Interview for DSM-IV evaluated MDD...
September 20, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27599815/relationships-among-psychoneurological-symptoms-and-levels-of-c-reactive-protein-over-2%C3%A2-years-in-women-with-early-stage-breast-cancer
#9
Angela Starkweather, Debra Lynch Kelly, Leroy Thacker, Michelle L Wright, Colleen K Jackson-Cook, Debra E Lyon
PURPOSE: The aim of the present study was to explore clusters of psychoneurological symptoms and inflammation (levels of C-reactive protein) over time in a cohort of women with early-stage breast cancer. Specifically, we examined the relationships among affective symptoms (depression, anxiety, fatigue, sleep disturbances, pain, and perceived stress), domains of cognitive performance, and levels of peripheral C-reactive over a period of 2 years. METHODS: This was a prospective, longitudinal study of 77 women diagnosed with early-stage breast cancer...
January 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27569105/melancholy-as-a-risk-factor-for-cancer-a-historical-overview
#10
Marianna Karamanou, Elias Tzavellas, Konstantinos Laios, Michalis Koutsilieris, George Androutsos
In antiquity, physicians related depression or melancholic humour to cancer's pathogenesis. Galen (130-201 AD), sustained that melancholy could give rise to a tumour and his theory was repeated by the Byzantine and Arab physicians. In the 19th century, malignancy and depression became synonymous and people attributed their cancer to sadness. In 1893, the London surgeon Hebert Snow (1847-1930), performed an epidemiological study in order to clarify that link. The results revealed a probable connection. His work was followed by several large scale prospective studies some of which identified depression as a risk factor for cancer where others found no association...
May 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/27543065/qigong-tai-chi-easy-for-fatigue-in-breast-cancer-survivors-rationale-and-design-of-a-randomized-clinical-trial
#11
Linda Larkey, Jennifer Huberty, Maja Pedersen, Karen Weihs
INTRODUCTION: Breast cancer survivors (BCSs) often report fatigue that persists for years following treatment. Despite a growing body of evidence for meditative movement practices to improve symptoms among BCSs, few studies have explored using Qigong/Tai Chi to reduce fatigue. Additionally, few have examined the biological mechanisms through which fatigue may be reduced using Qigong/Tai Chi. METHODS/STUDY DESIGN: We will recruit 250 fatigued, post-menopausal women diagnosed with breast cancer (stage 0-III), between 6months and 5years past primary treatment and randomize to a standardized Qigong/Tai Chi Easy (QG/TCE) intervention, a "sham" Qigong group (movements without a focus on the breath and meditative state) (SQG), or an educational support (ES) group...
September 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27281085/elevated-neutrophil-to-lymphocyte-ratio-predicts-mortality-in-medical-inpatients-with-multiple-chronic-conditions
#12
Vivian Isaac, Chia-Yi Wu, Chun-Ta Huang, Bernhard T Baune, Chia-Lin Tseng, Craig S McLachlan
Neutrophil to lymphocyte ratio (NLR) is an easy measurable laboratory marker used to evaluate systemic inflammation. Elevated NLR is associated with poor survival and increased morbidity in cancer and cardiovascular disease. However, the usefulness of NLR to predict morbidity and mortality in a hospital setting for patients with multiple chronic conditions has not been previously examined. In this study, we investigate the association between NLR and mortality in multimorbid medical inpatients. Two hundred thirty medical in-patients with chronic conditions were selected from a single academic medical center in Taiwan...
June 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27257445/intradialytic-massage-for-leg-cramps-among-hemodialysis-patients-a-pilot-randomized-controlled-trial
#13
Diane Mastnardo, Janice M Lewis, Kristi Hall, Catherine M Sullivan, Katrice Cain, Jacqueline Theurer, Anne Huml, Ashwini R Sehgal
BACKGROUND: Patients on hemodialysis often experience muscle cramps that result in discomfort, shortened treatment times, and inadequate dialysis dose. Cramps have been associated with adversely affecting sleep and health-related quality of life, depression and anxiety. There is limited evidence available about massage in dialysis; however, massage in cancer patients has demonstrated decreases in pain, inflammation, and feelings of anxiety. These correlations indicate massage may be an effective treatment modality for hemodialysis-related lower extremity cramping...
June 2016: International Journal of Therapeutic Massage & Bodywork
https://www.readbyqxmd.com/read/27251602/5-fluorouracil-induced-acute-reversible-heart-failure-not-explained-by-coronary-spasms-myocarditis-or-takotsubo-lessons-from-mri
#14
Yama Fakhri, Morten Dalsgaard, Dorte Nielsen, Per Lav Madsen
A 69-year-old woman presented with arterial hypotension, pulmonary oedema and a severely depressed left ventricular ejection fraction (LVEF) of 25% only 3 days after having received her first treatment for colorectal cancer with 5-fluorouracil (5-FU)-based therapy. The ECG demonstrated widespread ST-segment depression and echocardiography showed uniform hypokinesia of all left ventricular (LV) myocardial segments without signs of regional LV ballooning. Coronary angiography was normal and the patient gained full recovery after receiving treatment with heart failure medication...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27221627/role-of-kynurenine-metabolism-pathway-activation-in-major-depressive-disorders
#15
Jonathan Savitz
A proportion of depressed individuals show evidence of inflammation. Both animal, quasi-experimental, and longitudinal studies indicate that inflammatory processes may play a causal role in the developmental of depressive illness. While there may be multiple causal pathways through which inflammatory processes affect mood, activation of the kynurenine pathway is essential for the development of depression-like behavior in rodents. Studies of hepatitis C or cancer patients receiving treatment with inflammation-inducing medications show increased activation of the kynurenine pathway and decreased levels of tryptophan that correlate with inflammation-induced depression...
May 25, 2016: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/27215580/febuxostat-exerts-dose-dependent-renoprotection-in-rats-with-cisplatin-induced-acute-renal-injury
#16
Alaa N A Fahmi, George S G Shehatou, Abdelhadi M Shebl, Hatem A Salem
The aim of the present study was to investigate possible renoprotective effects of febuxostat, a highly potent xanthine oxidase inhibitor, against cisplatin (CIS)-induced acute kidney injury in rats. Male Sprague Dawley rats were randomly assigned into four groups of six rats each, as follows: normal control; CIS, received a single intraperitoneal injection of CIS (7.5 mg/kg); [febuxostat 10 + CIS] and [febuxostat 15 + CIS], received febuxostat (10 and 15 mg/kg/day, respectively, orally) for 14 days, starting 7 days before CIS injection...
August 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27123286/diagnosis-of-lateral-pelvic-lymph-node-metastasis-of-t1-lower-rectal-cancer-using-diffusion-weighted-magnetic-resonance-imaging-a-case-report-with-lateral-pelvic-lymph-node-dissection-of-lower-rectal-cancer
#17
Shimpei Ogawa, Michio Itabashi, Tomoichiro Hirosawa, Takuzo Hashimoto, Yoshiko Bamba, Takahiro Okamoto
The present study presented a 35-year-old female patient in whom fecal occult blood was detected in a medical check-up. Colonoscopy revealed a superficial elevated-type tumor with central depression in the lower rectum. The tumor was diagnosed as T1 deep invasive cancer. No swollen lymph nodes or distant metastasis were found on computed tomography or [(18)F]-fluorodeoxyglucose-positron emission tomography with computed tomography. However, a swollen right lateral pelvic lymph node (LPLN; short axis 4 mm) was revealed on magnetic resonance imaging (MRI)...
May 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27057694/a-roadmap-for-investigating-the-role-of-the-prion-protein-in-depression-associated-with-neurodegenerative-disease
#18
Danielle Beckman, Rafael Linden
The physiological properties of the native, endogenous prion protein (PrP(C)) is a matter of concern, due to its pleiotropic functions and links to neurodegenerative disorders and cancer. In line with our hypothesis that the basic function of PrP(C) is to serve as a cell surface scaffold for the assembly of signaling modules, multiple interactions have been identified of PrP(C) with signaling molecules, including neurotransmitter receptors. We recently reported evidence that PrP(C) may modulate monoaminergic neurotransmission, as well as depressive-like behavior in mice...
March 3, 2016: Prion
https://www.readbyqxmd.com/read/26967918/val66met-bdnf-polymorphism-as-a-vulnerability-factor-for-inflammation-associated-depressive-symptoms-in-women-with-breast-cancer
#19
Larissa N Dooley, Patricia A Ganz, Steve W Cole, Catherine M Crespi, Julienne E Bower
BACKGROUND: Inflammation contributes to the development of depression in a subset of individuals, but risk factors that render certain individuals particularly vulnerable to inflammation-associated depression are undetermined. Drawing from animal studies showing that reduced neuroplasticity mediates effects of inflammation on depression, we hypothesized that individuals genetically predisposed to lower levels of neuroplasticity would be more susceptible to inflammation-associated depression...
June 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/26853341/resistance-exercise-and-inflammation-in-breast-cancer-patients-undergoing-adjuvant-radiation-therapy-mediation-analysis-from-a-randomized-controlled-intervention-trial
#20
Martina E Schmidt, Anna Meynköhn, Nina Habermann, Joachim Wiskemann, Jan Oelmann, Holger Hof, Sabine Wessels, Oliver Klassen, Jürgen Debus, Karin Potthoff, Karen Steindorf, Cornelia M Ulrich
PURPOSE: To explore the mediating role of inflammatory parameters in the development of fatigue, pain, and potentially related depressive symptoms during radiation therapy for breast cancer and its mitigation by resistance exercise. METHODS AND MATERIALS: Breast cancer patients scheduled for adjuvant radiation therapy were randomized to 12-week progressive resistance exercise training (EX) or a relaxation control group. Interleukin-6 (IL-6) and interleukin-1 receptor antagonist (IL-1ra) were measured in serum samples collected before, at the end, and 6 weeks after radiation therapy from 103 chemotherapy-naïve participants...
February 1, 2016: International Journal of Radiation Oncology, Biology, Physics
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