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https://www.readbyqxmd.com/read/28342580/evidence-based-management-of-chylothorax-in-infants
#1
Joseph T Church, Alexis G Antunez, Ashley Dean, Niki Matusko, Kristopher B Deatrick, Mohammad A Attar, Samir K Gadepalli
PURPOSE: Management guidelines for infants with chylothorax lack substantial evidence. We sought to identify variables that impact outcomes in these patients in order to develop an evidence-based management algorithm. METHODS: We retrospectively reviewed the medical records of all infants diagnosed with chylothorax from June 2005 to December 2014 at our institution. Data collected included demographics, chest tube output (CTO), medical and dietary interventions, surgical procedures, and absolute lymphocyte count (ALC)...
March 16, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28273553/trial-sponsorship-and-self-reported-conflicts-of-interest-in-breast-cancer-radiation-therapy-an-analysis-of-prospective-clinical-trials
#2
Elton T T Leite, Fabio Y Moraes, Gustavo N Marta, Neil K Taunk, Marina T L Vieira, Samir A Hanna, João Luis F Silva, Heloisa A Carvalho
PURPOSE: We aim to assess any association between study and self-reported conflict of interest (COI) or trial sponsorship in breast cancer radiation clinical trials. MATERIALS AND METHODS: We searched PubMed for all clinical trials (CTs) published between 09/2004 and 09/2014 related to breast cancer. We included only radiotherapy CTs with primary clinical endpoints. We classified eligible trials according to the funding source, presence or absence of conflict of interest, study conclusion and impact factor (IF)...
March 5, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28152729/reducing-hospital-aquired-pneumonia-hap-with-massey-screen
#3
Robyn Dunbar, Cheryl Clements, Margaret Bonawitz, Joanne McGovern
232 Background: Hospital Acquired Pneumonia (HAP) is a leading cause of prolonged hospitalization in patients. The oncology population is especially susceptible to critical illness related to an immunocompromised state. The purpose of this study was to implement the Massey Bedside Swallowing Screen upon admission to the oncology telemetry unit to detect any deficits that could potentially lead to HAP, in conjunction with strict oral care for identified high risk patients. METHODS: The importance of the Massey Bedside Swallowing Screen upon admission and the knowledge that early detection leads to better patient outcomes was educated to the nursing staff...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28125828/characteristics-and-outcomes-of-fasting-orders-among-medical-inpatients
#4
Atsushi Sorita, Charat Thongprayoon, John T Ratelle, Ruth E Bates, Katie M Rieck, Aditya P Devalapalli, Adil Ahmed, Deanne T Kashiwagi
While many hospitalized patients have orders to fast in preparation for interventions, the extent to which these orders are necessary or adhere to evidence-based durations is unknown. In this study, we analyzed the length, indication, and associated outcomes of nil per os (NPO) orders for general medicine patients at an academic institution in the United States, and compared them to the best available evidence for recommended length of NPO. Of 924 NPO orders assessed, the indicated intervention was not performed for 183 (19...
January 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28111419/chemical-colitis-caused-by-hydrogen-peroxide-enema-in-a-child-case-report-and-literature-review
#5
Joon Sang Lee, Jung Kyung Yoo
A 2-year-old girl, previously healthy, was brought to the emergency department because of significant cramping abdominal pain with recurrent hematochezia after an accidental hydrogen peroxide enema (35%, 5 mL) by her caregiver. She was hospitalized to the pediatric department and treated with nothing per mouth, intravenous fluid and parenteral antibiotic therapy. Laboratory, radiologic and endoscopic evaluation was performed during the admission period. She was discharged in a fully recovered state on the tenth hospital day, and this is the first case report of acute chemical colitis by accidental hydrogen peroxide enema in children...
2016: Environmental Health and Toxicology
https://www.readbyqxmd.com/read/28090472/prevalence-and-risk-factors-for-the-weight-loss-during-hospitalization-in-children-a-single-korean-children-s-hospital-experience
#6
Eun Ha Hwang, Jae Hong Park, Peter Chun, Yeoun Joo Lee
PURPOSE: Undernutrition during hospitalization increases the risk of nosocomial infection and lengthens the disease courses. The aim of this study was to evaluate the risk factors of weight loss during hospitalization in children. METHODS: All the patients who were admitted in general wards between April and May 2014 were enrolled. Patients aged >18 years and discharged within 2 days were excluded. Weight loss during hospitalization was defined as a decrease in body weight of >2% in 8 hospital days or on the day of discharge...
December 2016: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/28077744/neuropsychiatric-outcomes-after-mefloquine-exposure-among-u-s-military-service-members
#7
Angelia A Eick-Cost, Zheng Hu, Patricia Rohrbeck, Leslie L Clark
Mefloquine was widely prescribed to U.S. military service members until 2009 when use was limited to personnel with contraindications to doxycycline and no contraindications to mefloquine. The need to estimate the occurrence of neuropsychiatric outcomes (NPOs) in service members prescribed mefloquine warranted a comprehensive evaluation of this issue. Active component service members filling a prescription for mefloquine, doxycycline, or atovaquone/proguanil (A/P) between January 1, 2008 and June 30, 2013, were included in the analysis...
January 11, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28075017/intrapopulation-variability-in-the-timing-of-ontogenetic-habitat-shifts-in-sea-turtles-revealed-using-%C3%AE-15-n-values-from-bone-growth-rings
#8
Calandra N Turner Tomaszewicz, Jeffrey A Seminoff, S Hoyt Peckham, Larisa Avens, Carolyn M Kurle
Determining location and timing of ontogenetic shifts in the habitat use of highly migratory species, along with possible intrapopulation variation in these shifts, is essential for understanding mechanisms driving alternate life histories and assessing overall population trends. Measuring variations in multi-year habitat-use patterns is especially difficult for remote oceanic species. To investigate the potential for differential habitat use among migratory marine vertebrates, we measured the naturally occurring stable nitrogen isotope (δ(15) N) patterns that differentiate distinct ocean regions to create a 'regional isotope characterization', analysed the δ(15) N values from annual bone growth layer rings from dead-stranded animals, and then combined the bone and regional isotope data to track individual animal movement patterns over multiple years...
January 11, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28033074/preoperative-feeding-neonates-with-cardiac-disease
#9
Carly J Scahill, Eric M Graham, Andrew M Atz, Scott M Bradley, Minoo N Kavarana, Sinai C Zyblewski
BACKGROUND: The potential for necrotizing enterocolitis (NEC) in neonates requiring cardiac surgery has contributed largely to wide feeding practice variations and a hesitation to initiate enteral feeding during the preoperative period, specifically those patients with hypoplastic left heart syndrome. METHODS: A retrospective chart review of neonates undergoing cardiac surgery at a single institution between July 2011 and July 2013 was performed. The primary objective of this study was to determine if preoperative feeding was associated with NEC in neonates requiring cardiac surgery...
January 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/28004368/control-of-the-pollution-of-antibiotic-resistance-genes-in-soils-by-quorum-sensing-inhibition
#10
Bai-Min Lai, Kun Zhang, Dong-Sheng Shen, Mei-Zhen Wang, Jia-Li Shentu, Na Li
To investigate whether pollution from antibiotic resistance genes (ARGs) could be affected by bacterial quorum sensing, the oxytetracycline (OTC)-containing manure was fertilized to establish the ARG-polluted soil environment. Under long-term OTC stress, substantial ARGs in the range from 10(-4) to 10(-3) RG/16S rRNA (resistance genes/16S rRNA) were detected in the antibiotics control (AC) group, in which OTC-containing manure was fertilized. Meanwhile, 10(-6) RG/16S rRNA was detected in biological control (BC) group, in which non-OTC-containing manure was fertilized...
December 21, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27847669/novel-approach-for-enterocutaneous-fistula-treatment-with-the-use-of-viable-cryopreserved-placental-membrane
#11
Frederick Nichols, Aaron Overly
Enterocutaneous fistulas (ECF) are a difficult and costly surgical complication to manage. The standard treatment of nil per os (NPO) and total paraenteral nutrition (TPN) is not well tolerated by patients. TPN is also known for complications associated with long term central venous catheterization and for high cost of prolonged hospital stay. We present two low output ECF cases successfully treated with viable cryopreserved placental membrane (vCPM) placed into the fistula tracts. One patient is a 59-year-old male with a low output ECF from a jejunostomy tube site four weeks after the surgery...
2016: Case Reports in Surgery
https://www.readbyqxmd.com/read/27847496/revising-the-intolerance-of-uncertainty-model-of-generalized-anxiety-disorder-evidence-from-uk-and-italian-undergraduate-samples
#12
Gioia Bottesi, Marta Ghisi, Eleonora Carraro, Nicola Barclay, Rebecca Payne, Mark H Freeston
The Intolerance of Uncertainty Model (IUM) of Generalized Anxiety Disorder (GAD) attributes a key role to Intolerance of Uncertainty (IU), and additional roles to Positive Beliefs about Worry (PBW), Negative Problem Orientation (NPO), and Cognitive Avoidance (CA), in the development and maintenance of worry, the core feature of GAD. Despite the role of the IUM components in worry and GAD has been considerably demonstrated, to date no studies have explicitly assessed whether and how PBW, NPO, and CA might turn IU into worry and somatic anxiety...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27844200/-education-within-the-dutch-national-care-for-the-elderly-programme
#13
Barth Oeseburg, Jos Schols, Marcel Olde Rikkert, Henriëtte van der Horst, Dini Smilde-van den Doel, Sophia de Rooij, Bianca Buurman-van Es, Marieke Schuurmans, Jacobijn Gussekloo
The Netherlands Organisation of Health Research and Development started in 2008 the Dutch National Care for the Elderly Programme (in Dutch abbreviated as NPO) with the aim to improve the quality of life for the frail older people through better quality of care (health, social, community) which is tailored to the needs and wants of older people. The delivery of good care is related with competent professional behaviour which is inextricably linked to the education of professionals. This article presents an overview of 32 educational programmes developed within the NPO...
December 2016: Tijdschrift Voor Gerontologie en Geriatrie
https://www.readbyqxmd.com/read/27843708/prospective-preliminary-in-vitro-investigation-of-a-magnetic-iron-oxide-nanoparticle-conjugated-with-ligand-cd80-and-vegf-antibody-as-a-targeted-drug-delivery-system-for-the-induction-of-cell-death-in-rodent-osteosarcoma-cells
#14
AnneMarie Kay Kovach, Jen M Gambino, Vina Nguyen, Zach Nelson, Taylor Szasz, Jun Liao, Lakiesha Williams, Sandra Bulla, Raj Prabhu
Target drug deliveries using nanotechnology are a novel consideration in the treatment of cancer. We present herein an in vitro mouse model for the preliminary investigation of the efficacy of an iron oxide nanoparticle complex conjugated to vascular endothelial growth factor (VEGF) antibody and ligand cluster of differentiation 80 (CD80) for the purpose of eventual translational applications in the treatment of human osteosarcoma (OSA). The 35 nm diameter iron oxide magnetic nanoparticles are functionalized with an n-hydroxysuccinimide biocompatible coating and are conjugated on the surface to proteins VEGF antibody and ligand CD80...
2016: BioResearch Open Access
https://www.readbyqxmd.com/read/27827291/-general-practitioner-and-specialist-elderly-care-medicine-paramount-a-strong-pairing-in-the-care-of-the-vulnerable-elderly
#15
C M P M Verheugt, J F Bastiaans
The Dutch National Care for the Elderly Programme (NPO) was launched as a large-scale project, in which screening for vulnerability, followed by a comprehensive geriatric assessment, played an important role. An oft-cited explanation for the poor effects of the NPO projects is the high quality of Dutch primary care. However, the complexity of frail elderly care raises the question as to whether the competence of a nurse or practice nurse is sufficient to ensure proper care and treatment. Moreover, studies used vulnerability as a risk status, as if vulnerability were reversible...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27792968/thinking-about-worry-investigation-of-the-cognitive-components-of-worry-in-children
#16
Caroline L Donovan, Monique C Holmes, Lara J Farrell, Catherine S Hearn
BACKGROUND: Despite being extensively studied in adults, investigation of worry and it's associated cognitive variables remains in its infancy in paediatric samples. AIMS: This study aimed to investigate 1) whether the child cognitive variables of intolerance of uncertainty (IU), positive beliefs about worry (PBW), negative beliefs about worry (NBW), negative problem orientation (NPO) and cognitive avoidance (CA) were associated with child worry, 2) whether parental worry and cognitive variables were associated with child worry, 3) whether the relationship between child and parent worry was mediated by child cognitive variables and 4) whether the relationships between specific parent cognitive factors and child worry were mediated by specific child cognitive factors...
January 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27775609/meta-analysis-of-early-nutrition-the-benefits-of-enteral-feeding-compared-to-a-nil-per-os-diet-not-only-in-severe-but-also-in-mild-and-moderate-acute-pancreatitis
#17
Katalin Márta, Nelli Farkas, Imre Szabó, Anita Illés, Áron Vincze, Gabriella Pár, Patrícia Sarlós, Judit Bajor, Ákos Szűcs, József Czimmer, Dóra Mosztbacher, Andrea Párniczky, Kata Szemes, Dániel Pécsi, Péter Hegyi
The recently published guidelines for acute pancreatitis (AP) suggest that enteral nutrition (EN) should be the primary therapy in patients suffering from severe acute pancreatitis (SAP); however, none of the guidelines have recommendations on mild and moderate AP (MAP). A meta-analysis was performed using the preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P). The following PICO (problem, intervention, comparison, outcome) was applied: P: nutrition in AP; I: enteral nutrition (EN); C: nil per os diet (NPO); and O: outcome...
October 20, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27754207/apsh-yi-06-effects-of-angiotensin-ii-type-2-receptor-in-fetal-growth-restriction-mice
#18
Toshifumi Yamauchi, Masaki Mogi, Hirotomo Nakaoka, Kana Tsukuda, Masanori Kukida, Akinori Higaki, Hui-Yu Bai, Bao-Shuai Shan, Li-Juan Min, Jun Iwanami, Masatugu Horiuchi
OBJECTIVE: Fetal growth restriction (FGR) is one of the risks of cardiovascular problems in adulthood. We previously reported that the vascular injury enhanced vascular remodeling in FGR mice, but the mechanisms are still unclear. Angiotensin II type 2 receptor (AT2R) is relatively highly expressed in fetal mice but not in adult mice. Therefore, we investigated the effects of AT2R in FGR mice, using AT2R knockout (AT2KO) mice. DESIGN AND METHOD: Dams (C57BL/6J strain (WT) mice and AT2KO mice) were fed an isocaloric diet containing 20% protein (normal protein; NP) or 8% protein (low protein; LP) from 10 weeks of age until delivery...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27744124/a-worrying-trend-in-social-anxiety-to-what-degree-are-worry-and-its-cognitive-factors-associated-with-youth-social-anxiety-disorder
#19
Cate S Hearn, Caroline L Donovan, Susan H Spence, Sonja March
BACKGROUND: Comorbidity between Social Anxiety Disorder (SAD) and Generalized Anxiety Disorder (GAD) is extremely common. This study investigated whether factors commonly associated with GAD, including worry, intolerance of uncertainty (IU), positive and negative beliefs about worry (PBW, NBW), negative problem orientation (NPO) and cognitive avoidance (CA) were associated with SAD severity, symptoms and overall functioning. METHOD: Participants included 126 youth aged 8-17 years (M=11...
January 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27719738/bendamustine-induced-nephrogenic-diabetes-insipidus%C3%A2
#20
Benjamin A Derman, Milli Jain, Elizabeth A McAninch, Casey Gashti
A 59-year-old man presented with polyuria and polydipsia immediately following his sixth cycle of rituximab and bendamustine for chronic lymphocytic leukemia. He initially compensated by increasing his oral fluid intake at home, but later developed septic shock and was admitted with orders to be kept nil per os (NPO). This prompted an episode of acute hypernatremia during which he exhibited continued polyuria with inappropriately dilute urine. Desmopressin challenge yielded no response in the urine osmolality, indicating a nephrogenic source of his diabetes insipidus (DI)...
January 2017: Clinical Nephrology
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