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https://www.readbyqxmd.com/read/28830117/analysis-of-dextromethorphan-and-dextrorphan-in-skeletal-remains-following-differential-microclimate-exposure-comparison-of-acute-vs-repeated-drug-exposure
#1
Lucas M Morrison, Kirk A Unger, James H Watterson
Analysis of dextromethorphan (DXM) and its metabolite dextrorphan (DXT) in skeletal remains of rats following acute (ACU, 75 mg/kg, IP, n = 10) or three repeated (REP, 25 mg/kg, IP, n = 10, 40-min interval) doses of DXM is described. Following dosing and euthanasia, rats decomposed outdoors to skeleton in two different microclimate environments (n = 5 ACU and n = 5 REP at each site): Site A (shaded forest microenvironment) and Site B (rocky substrate exposed to direct sunlight, 600 m from Site A). Two drug-free rats at each site served as negative controls...
July 1, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28830038/spectroscopic-studies-of-the-intramolecular-hydrogen-bonding-in-o-hydroxy-schiff-bases-derived-from-diaminomaleonitrile-and-their-deprotonation-reaction-products
#2
Anna Szady-Chełmieniecka, Beata Kołodziej, Maja Morawiak, Bohdan Kamieński, Wojciech Schilf
The structural study of five Schiff bases derived from diaminomaleonitrile (DAMN) and 2-hydroxy carbonyl compounds was performed using (1)H, (13)C and (15)N NMR methods in solution and in the solid state as well. ATR-FTIR and X-Ray spectroscopies were used for confirmation of the results obtained by NMR method. The imine obtained from DAMN and benzaldehyde was synthesized as a model compound which lacks intramolecular hydrogen bond. Deprotonation of all synthesized compounds was done by treating with tetramethylguanidine (TMG)...
August 12, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28830033/quartz-crystal-microbalance-sensing-cell-substrate-adhesion-and-beyond
#3
REVIEW
Jennifer Y Chen, Lynn S Penn, Jun Xi
Cell adhesion is an essential aspect of cellular behavior. Finding innovative methods to probe the adhesion of cells in their native state can greatly advance the understanding of control and regulation of cellular behavior and their impact on human health. The quartz crystal microbalance (QCM) is a label-free, biosensing system that has, in the past fifty years, evolved from a simple acoustic based mass sensor to a powerful bioanalytical tool. Its unique capability of monitoring the cell-substrate interaction non-invasively in real time has led to the emergence of its applications in areas that are relevant to fundamental cell biology and medical research...
August 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28829992/health-related-quality-of-life-results-from-the-prodige-5-accord-17-randomised-trial-of-folfox-versus-fluorouracil-cisplatin-regimen-in-oesophageal-cancer
#4
C Bascoul-Mollevi, S Gourgou, M-P Galais, J-L Raoul, O Bouché, J-Y Douillard, A Adenis, P-L Etienne, B Juzyna, L Bedenne, T Conroy
BACKGROUND: A recent prospective randomised trial did not reveal significant differences in median progression-free survival between two chemoradiotherapy (CRT) regimens for inoperable non-metastatic oesophageal cancer patients. This secondary analysis aimed to describe the impact of CRT on health-related quality of life (HRQOL), physical functioning, dysphagia, fatigue and pain and to evaluate whether baseline HRQOL domains can predict overall survival. PATIENTS AND METHODS: A total of 267 patients were randomly assigned to receive with 50 Gy of radiotherapy in 25 fractions six cycles of FOLFOX or four cycles of fluorouracil and cisplatin on day 1...
August 19, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28829985/follow-up-study-of-idiopathic-generalized-epilepsy-with-associated-absence-seizure-and-myoclonic-epilepsy-of-infancy
#5
Vincenzo Belcastro, Lucio Giordano, Dario Pruna, Cinzia Peruzzi, Susanna Casellato, Salvatore Barca, Giorgia Carlone, Pasquale Striano, Alberto Verrotti
We evaluated the long-term prognosis of patients featuring the association of absences and myoclonic epilepsy of infancy. Our cohort consisted of 10 male subjects with mean age at seizure onset of 29 months. Follow-up data included seizure outcome and EEG findings. All individuals received antiepileptic drugs (AEDs) as monotherapy (6 patients) or polytherapy (4 patients) for a mean period of 24 months. Over a 30-60 month evaluation period (mean: 43 months), all patients were seizure-free. Follow-up data after withdrawal of antiepileptic therapy were obtained for a mean period of 22 months...
August 14, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28829984/vacuum-pyrolysis-characteristics-and-parameter-optimization-of-recycling-organic-materials-from-waste-tantalum-capacitors
#6
Zhenyang Chen, Bo Niu, Lingen Zhang, Zhenming Xu
Recycling rare metal tantalum from waste tantalum capacitors (WTCs) is significant to alleviate the shortage of tantalum resource. However, environmental problems will be caused if the organic materials from WTCs are improperly disposed. This study presented a promising vacuum pyrolysis technology to recycle the organic materials from WTCs. The organics removal rate could reach 94.32wt% according to TG results. The optimal parameters were determined as 425°C, 50Pa and 30min on the basis of response surface methodology (RSM)...
August 12, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28829975/jugulodigastric-lymph-node-size-by-age-on-ct-in-an-adult-cancer-free-population
#7
Leticia M B Costa E Silva Souza, Katherine J Leung, Anne O'Neill, Jagadeesan Jayender, Thomas C Lee
PURPOSE: Evaluate jugulodigastric node size in cancer-free patients. METHODS: Retrospective review of 234 neck CT angiograms was performed. Known neoplasm, inflammation or poor imaging were excluded. Maximal diameter of the largest jugulodigastric node in the axial plane bilaterally was measured. RESULTS: 172 patients (median age=62) were included. Jugulodigastric node size decreased with age and was statistically significant between those above and below 62years...
July 26, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28829951/collagenase-treatment-enhances-proteomic-coverage-of-low-abundance-proteins-in-decellularized-matrix-bioscaffolds
#8
Miljan Kuljanin, Cody F C Brown, Matthew J Raleigh, Gilles A Lajoie, Lauren E Flynn
There is great interest in the application of advanced proteomic techniques to characterize decellularized tissues in order to develop a deeper understanding of the effects of the complex extracellular matrix (ECM) composition on the cellular response to these pro-regenerative bioscaffolds. However, the identification of proteins in ECM-derived bioscaffolds is hindered by the high abundance of collagen in the samples, which can interfere with the detection of lower-abundance constituents that may be important regulators of cell function...
August 13, 2017: Biomaterials
https://www.readbyqxmd.com/read/28829911/chemoradiotherapy-versus-chemoradiotherapy-plus-surgery-for-esophageal-cancer
#9
REVIEW
Balamurugan A Vellayappan, Yu Yang Soon, Geoffrey Y Ku, Cheng Nang Leong, Jiade J Lu, Jeremy Cs Tey
BACKGROUND: Please see Appendix 4 for a glossary of terms.The outcome of patients with esophageal cancer is generally poor. Although multimodal therapy is standard, there is conflicting evidence regarding the addition of esophagectomy to chemoradiotherapy. OBJECTIVES: To compare the effectiveness and safety of chemoradiotherapy plus surgery with that of chemoradiotherapy alone in people with nonmetastatic esophageal carcinoma. SEARCH METHODS: We performed a computerized search for relevant studies, up to Feburary 2017, on the CENTRAL, MEDLINE, and Embase databases using MeSH headings and keywords...
August 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28829877/effect-of-ganciclovir-on-il-6-levels-among-cytomegalovirus-seropositive-adults-with-critical-illness-a-randomized-clinical-trial
#10
Ajit P Limaye, Renee D Stapleton, Lili Peng, Scott R Gunn, Louise E Kimball, Robert Hyzy, Matthew C Exline, D Clark Files, Peter E Morris, Stephen K Frankel, Mark E Mikkelsen, Duncan Hite, Kyle B Enfield, Jay Steingrub, James O'Brien, Polly E Parsons, Joseph Cuschieri, Richard G Wunderink, David L Hotchkin, Ying Q Chen, Gordon D Rubenfeld, Michael Boeckh
Importance: The role of cytomegalovirus (CMV) reactivation in mediating adverse clinical outcomes in nonimmunosuppressed adults with critical illness is unknown. Objective: To determine whether ganciclovir prophylaxis reduces plasma interleukin 6 (IL-6) levels in CMV-seropositive adults who are critically ill. Design, Setting, and Participants: Double-blind, placebo-controlled, randomized clinical trial (conducted March 10, 2011-April 29, 2016) with a follow-up of 180 days (November 10, 2016) that included 160 CMV-seropositive adults with either sepsis or trauma and respiratory failure at 14 university intensive care units (ICUs) across the United States...
August 22, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28829842/voice-in-different-phases-of-menstrual-cycle-among-naturally-cycling-women-and-users-of-hormonal-contraceptives
#11
Irena Pavela Banai
Previous studies have shown changes in women's behavior and physical appearance between the non-fertile and fertile phases of the menstrual cycle. It is assumed that these changes are regulated by fluctuations in sex hormone levels across the cycle. Receptors for sex hormones have been found on the vocal folds, suggesting a link between hormone levels and vocal fold function, which might cause changes in voice production. However, attempts to identify changes in voice production across the menstrual cycle have produced mixed results...
2017: PloS One
https://www.readbyqxmd.com/read/28829831/no-significant-htlv-seroprevalence-in-german-people-who-inject-drugs
#12
Oliver Hohn, Stephen Norley, Claudia Kücherer, Ali Bazarbachi, Hiba El Hajj, Ulrich Marcus, Ruth Zimmermann, Norbert Bannert
BACKGROUND: Although human T-lymphotropic virus (HTLV) is transmitted via the same routes as human immunodeficiency virus (HIV), its worldwide seroprevalence differs drastically because HTLV is transmitted mainly via infected cells rather than free virus. The sharing of needles and other equipment places people who inject drugs (PWID) at particularly high-risk for such blood-borne diseases. METHODS: To validate the methodology used to process and analyze the dried blood spots (DBS) utilized in the study, dried serum spots (DSS) with dilutions of sera from known HTLV infected individuals were analyzed by ELISA and Western blot...
2017: PloS One
https://www.readbyqxmd.com/read/28829813/clinical-validation-of-a-highly-sensitive-assay-to-detect-egfr-mutations-in-plasma-cell-free-dna-from-patients-with-advanced-lung-adenocarcinoma
#13
Yuping Li, Hanyan Xu, Shanshan Su, Junru Ye, Junjie Chen, Xuru Jin, Quan Lin, Dongqing Zhang, Caier Ye, Chengshui Chen
BACKGROUND: Circulating tumor DNA (ctDNA) is a promising biomarker for noninvasive epidermal growth factor receptor (EGFR) mutations detection in lung cancer patients, but the existing methods have limitations in sensitivity or in availability. In this study, we evaluated the performance of a novel assay called ADx-SuperARMS in detecting EGFR mutations in plasma cell-free DNA from patients with advanced lung adenocarcinoma. METHODS: A total of 109 patients with metastatic advanced adenocarcinoma were recruited who provided both blood samples and matched tumor tissue samples...
2017: PloS One
https://www.readbyqxmd.com/read/28829811/crystal-digital-droplet-pcr-for-detection-and-quantification-of-circulating-egfr-sensitizing-and-resistance-mutations-in-advanced-non-small-cell-lung-cancer
#14
Cécile Jovelet, Jordan Madic, Jordi Remon, Aurélie Honoré, Romain Girard, Etienne Rouleau, Barbara André, Benjamin Besse, Magali Droniou, Ludovic Lacroix
Over the past years, targeted therapies using tyrosine kinase inhibitors (TKI) have led to an increase in progression-free survival and response rate for a subgroup of non-small cell lung cancer (NSCLC) patients harbouring specific gene abnormalities compared with chemotherapy. However long-lasting tumor regression is rarely achieved, due to the development of resistant tumoral subclones, which requires alternative therapeutic approaches. Molecular profile at progressive disease is a challenge for making adaptive treatment decisions...
2017: PloS One
https://www.readbyqxmd.com/read/28829807/meld-mixed-effects-for-large-datasets
#15
Dylan M Nielson, Per B Sederberg
Mixed effects models provide significant advantages in sensitivity and flexibility over typical statistical approaches to neural data analysis, but mass univariate application of mixed effects models to large neural datasets is computationally intensive. Threshold free cluster enhancement also provides a significant increase in sensitivity, but requires computationally-intensive permutation-based significance testing. Not surprisingly, the combination of mixed effects models with threshold free cluster enhancement and nonparametric permutation-based significance testing is currently completely impractical...
2017: PloS One
https://www.readbyqxmd.com/read/28829806/genome-engineering-in-bacillus-anthracis-using-tyrosine-site-specific-recombinases
#16
Andrei P Pomerantsev, Rita M McCall, Margaret Chahoud, Nathan K Hepler, Rasem Fattah, Stephen H Leppla
Tyrosine site-specific recombinases (T-SSR) are polynucleotidyltransferases that catalyze cutting and joining reactions between short specific DNA sequences. We developed three systems for performing genetic modifications in Bacillus anthracis that use T-SSR and their cognate target sequences, namely Escherichia coli bacteriophage P1 Cre-loxP, Saccharomyces cerevisiae Flp-FRT, and a newly discovered IntXO-PSL system from B. anthracis plasmid pXO1. All three tyrosine recombinase systems were used for creation of a B...
2017: PloS One
https://www.readbyqxmd.com/read/28829785/dendrimer-doxorubicin-conjugates-exhibit-improved-anticancer-activity-and-reduce-doxorubicin-induced-cardiotoxicity-in-a-murine-hepatocellular-carcinoma-model
#17
Sibu P Kuruvilla, Gopinath Tiruchinapally, A Colleen Crouch, Mohamed E H ElSayed, Joan M Greve
Hepatocellular carcinoma (HCC) is the 2nd leading cause of cancer-related deaths every year globally. The most common form of treatment, hepatic arterial infusion (HAI), involves the direct injection of doxorubicin (DOX) into the hepatic artery. It is plagued with limited therapeutic efficacy and the occurrence of severe toxicities (e.g. cardiotoxicity). We aim to improve the therapeutic index of DOX delivered via HAI by loading the drug onto generation 5 (G5) poly(amidoamine) (PAMAM) dendrimers targeted to hepatic cancer cells via N-acetylgalactosamine (NAcGal) ligands...
2017: PloS One
https://www.readbyqxmd.com/read/28829677/braf-mutation-as-a-novel-driver-of-eosinophilic-cystitis
#18
Michael Y Choi, Igor F Tsigelny, Amelie Boichard, Åge A Skjevik, Ahmed Shabaik, Razelle Kurzrock
Eosinophilic cystitis is a rare manifestation of hypereosinophilia and a cause of morbidity, including dysuria and hematuria. Although some cases can be attributed to infection or allergy, most cases are assessed to be idiopathic and treated with corticosteroids. However, hypereosinophilia can also be due to actionable clonal molecular alterations in the hematopoietic cells, similar to other myeloproliferative neoplasms. Common mutations associated with eosonophilic syndromes are of platelet-derived growth factor receptor alpha or beta or c-kit, though other pathogenic mutations have been found by next generation sequencing...
August 22, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28829659/survival-outcome-after-stereotactic-body-radiation-therapy-and-surgery-for-early-stage-non-small-cell-lung-cancer-a-meta-analysis
#19
Xiao-Jun Yu, Wan-Rong Dai, Yong Xu
OBJECTIVE: Treatment modalities in medically compromised patients with early-stage non-small cell lung cancer (NSCLC) are controversial. Stereotactic body radiotherapy (SBRT) or stereotactic ablative radiotherapy has been increasingly recognized as a favorable alternative to surgical resection for early-stage NSCLC. Many retrospective analyses compared the efficacy of stereotactic body radiotherapy (SBRT) with surgery for early-stage non-small cell lung cancer (NSCLC). However, the efficacy between SBRT and surgery regimens for patients with early-stage NSCLC remains unclear...
August 22, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28829617/similarity-laws-for-the-lines-of-ideal-free-energy-and-chemical-potential-in-supercritical-fluids
#20
Evgeniy Mikhailovich Apfelbaum, Vladimir Sergeevich Vorob'ev
We have found the curves on the density-temperature plane, along which the values of free energy and chemical potential correspond to ideal gas quantities. At first, we have applied the van der Waals equation to construct them and to derive their equations. Then we have shown that the same lines for real substances (Ar, N2, CH4, SF6, H2, H2O) and for the model Lennard-Jones system constructed on the basis of the measurements data and calculations are well matched with the derived equations. The validity and deviations from the obtained similarity laws are discussed...
August 22, 2017: Journal of Physical Chemistry. B
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