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hematogenous oxidation therapy

Rowan Flynn, Joshua M Buckler, Chongren Tang, Francis Kim, David A Dichek
Arterial endothelial cells (EC) are attractive targets for gene therapy of atherosclerosis because they are accessible to hematogenous and catheter-based vector delivery and overlie atherosclerotic plaques. Vector-mediated expression-in EC-of proteins that mediate cholesterol transfer out of the artery wall and decrease inflammation could prevent and reverse atherosclerosis. However, clinical application of this strategy is limited by lack of a suitable gene-transfer vector. First-generation adenovirus (FGAd) is useful for EC gene transfer in proof-of-concept studies, but is unsuitable for atheroprotective human gene therapy because of limited duration of expression and proinflammatory effects...
December 2010: Molecular Therapy: the Journal of the American Society of Gene Therapy
Andreas Saleh, Michael Schroeter, Adrian Ringelstein, Hans-Peter Hartung, Mario Siebler, Ulrich Mödder, Sebastian Jander
BACKGROUND AND PURPOSE: Inflammation contributes to brain damage caused by ischemic stroke. Ultrasmall superparamagnetic iron oxide (USPIO)-enhanced MRI allows noninvasive monitoring of macrophage recruitment into ischemic brain lesions. In this study, we determined the extent of USPIO enhancement during early stages of ischemic stroke. METHODS: Twelve consecutive patients with typical clinical signs of stroke underwent multimodal stroke imaging at 1.5-T within 24 hours of symptom onset...
October 2007: Stroke; a Journal of Cerebral Circulation
S R S Neves, C R S Machado, A M T Pinto, A H D Borges, F Q Cunha, E R S Camargos
The rat model of hypertension induced by prolonged treatment with Nomega-nitro-L-arginine methyl ester (L-NAME) has been extensively used. However, the effects on cardiac autonomic innervation are unknown. Here, the cardiac sympathetic innervation is analyzed in parallel with myocardial lesions and leukocyte infiltration during L-NAME (40 mg/Kg body weight/day, orally) treatment. The occurrence of cardiomyocyte hypertrophy, a controversial matter, is also addressed. Degenerating cardiomyocytes and focal inflammation occurred one day after treatment...
2006: Histology and Histopathology
R Hakimi
No abstract text is available yet for this article.
January 22, 2004: MMW Fortschritte der Medizin
No abstract text is available yet for this article.
September 18, 1959: Ärztliche Wochenschrift
No abstract text is available yet for this article.
August 28, 1959: Medizinische Klinik
No abstract text is available yet for this article.
September 15, 1958: Hippokrates
No abstract text is available yet for this article.
August 30, 1957: Münchener Medizinische Wochenschrift
No abstract text is available yet for this article.
June 22, 1956: Medizinische Klinik
William H McBride, Keisuke S Iwamoto, Randi Syljuasen, Milena Pervan, Frank Pajonk
In the last few years, the ubiquitin(Ub)/proteasome system has become increasingly recognized as a controller of numerous physiological processes, including signal transduction, DNA repair, chromosome maintenance, transcriptional activation, cell cycle progression, cell survival, and certain immune cell functions. This is in addition to its more established roles in the removal of misfolded, damaged, and effete proteins. This review examines the role of the Ub/proteasome system in processes underlying the classical effects of irradiation on cells, such as radiation-induced gene expression, DNA repair and chromosome instability, oxidative damage, cell cycle arrest, and cell death...
September 1, 2003: Oncogene
T Okamoto, S Sakurada, J P Yang, J P Merin
We have identified novel signal transduction cascades in activating NF-kappa B, as well as its pathogenetic roles in various disease processes. By applying the basic knowledge obtained through these studies, we hope to find new therapeutic measures against currently incurable diseases such as hematogenic cancer cell metastasis, rheumatoid arthritis, and AIDS. We also propose a novel strategy in screening effective inhibitors against transcription factors. Elucidation of the cis-regulatory element for expression of pathogenetic genes and identification of the responsible transcription factor will not only facilitate the study of pathogenesis but will also promote the development of effective therapy...
1997: Current Topics in Cellular Regulation
J Vacl, K Bílá, M Princ, O Brücknerová, E Vaclová
No abstract text is available yet for this article.
February 18, 1966: Casopís Lékar̆ů C̆eských
W Friedel, F H Schulz, H Stadtlaender, G Bothe, J Schmäcke
No abstract text is available yet for this article.
March 23, 1967: Das Deutsche Gesundheitswesen
O Brücknerová, K Bílá, J Vacl, M Princ
No abstract text is available yet for this article.
December 1, 1967: Casopís Lékar̆ů C̆eských
W Friedel, G Volkheimer, G Bothe, H Stadtlaender, J Schmäcke
No abstract text is available yet for this article.
February 16, 1967: Das Deutsche Gesundheitswesen
G Bothe, W Friedel, G Volkheimer, H Dettbarn, H Stadtlaender, J Schmäcke
No abstract text is available yet for this article.
March 9, 1967: Das Deutsche Gesundheitswesen
P D Sponseller, H L Malech, E F McCarthy, S F Horowitz, G Jaffe, J I Gallin
Chronic granulomatous disease is a rare disorder of the oxidative metabolism of the white blood cells that results in immunodeficiency. In a retrospective review of the records of forty-two patients who had chronic granulomatous disease, we identified thirteen patients who had a total of twenty skeletal infections. Two types of infection were noted: Type 1, which resulted from a direct spread of the infection from an adjacent focus, usually of fungus or mycobacteria, and Type 2, which resulted from hematogenous spread, usually of Nocardia or more common bacteria...
January 1991: Journal of Bone and Joint Surgery. American Volume
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