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stenotrophomonas maltophilia

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https://www.readbyqxmd.com/read/29770716/new-pyrazinoquinazoline-alkaloids-isolated-from-a-culture-of-stenotrophomonas-maltophilia-qb-77
#1
Sheng-Yan Qian, Cai-Ling Yang, Afsar Khan, Rong-Xiang Chen, Ming-Song Wu, Li Tuo, Qian Wang, Jian-Guo Liu, Gui-Guang Cheng
Two new pyrazinoquinazoline alkaloids, epi-fiscalin D (1) and epi-fiscalin E (2), as well as three known analogues, norquinadoline A (3), quinadoline A (4), and fiscalin C (5), were isolated from ethyl acetate extract of the fermentation broth of Stentrophomonas maltophilia QB-77. The structures of new compounds were elucidated on the basis of extensive spectroscopic data analysis including UV, HRESIMS, and 1D and 2D NMR experiments. All the isolated compounds were tested for their in vitro cytotoxicity against five human cancer cell lines (SMMC-7721, MCF-7, HL-60, SW480, and A-549) and antibacterial activities against Bacillus subtilis, Escherichia coli, and Staphylococcus aureus...
May 17, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29769279/microbial-interactions-in-the-cystic-fibrosis-airway
#2
Ann M Granchelli, Frederick R Adler, Ruth H Keogh, Christiana Kartsonaki, David R Cox, Theodore G Liou
Interactions in the airway ecology of cystic fibrosis may alter organism persistence and clinical outcomes. Better understanding of such interactions could guide clinical decisions. We fitted logistic regression models using generalized estimating equations to longitudinal two-year patient cohorts in the Cystic Fibrosis Foundation Patient Registry, 2003-2011 to study associations between airway organisms present in each calendar year and their presence in the subsequent year. Models were adjusted for clinical characteristics and multiple observations per patient and tested for sensitivity to cystic fibrosis-specific treatments...
May 16, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29768625/detection-of-blandm-1-in-stenotrophomonas-maltophilia-isolated-from-brazilian-soil
#3
João Pedro Rueda Furlan, André Pitondo-Silva, Eliana Guedes Stehling
This study reports the presence of the blaNDM-1 gene in an isolate of Stenotrophomonas maltophilia obtained from a Brazilian soil, inside an IncA/C plasmid with ~ 45 Kb. To the best of our knowledge, this is the second report in the world and the first in Brazil of NDM-producing bacterium isolated from soil.
May 14, 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29765358/get_phylomarkers-a-software-package-to-select-optimal-orthologous-clusters-for-phylogenomics-and-inferring-pan-genome-phylogenies-used-for-a-critical-geno-taxonomic-revision-of-the-genus-stenotrophomonas
#4
Pablo Vinuesa, Luz E Ochoa-Sánchez, Bruno Contreras-Moreira
The massive accumulation of genome-sequences in public databases promoted the proliferation of genome-level phylogenetic analyses in many areas of biological research. However, due to diverse evolutionary and genetic processes, many loci have undesirable properties for phylogenetic reconstruction. These, if undetected, can result in erroneous or biased estimates, particularly when estimating species trees from concatenated datasets. To deal with these problems, we developed GET_PHYLOMARKERS, a pipeline designed to identify high-quality markers to estimate robust genome phylogenies from the orthologous clusters, or the pan-genome matrix (PGM), computed by GET_HOMOLOGUES...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29760139/clpa-and-htpx-proteases-are-involved-in-intrinsic-aminoglycoside-resistance-of-stenotrophomonas-maltophilia-and-are-potential-aminoglycoside-adjuvant-targets
#5
Hsin-Hui Huang, Yi-Tsung Lin, Peng-Ying Chen, Li-Hua Li, Hsiao-Chen Ning, Tsuey-Ching Yang
The linkage of protease-chaperon system, SmeYZ pump, and aminoglycoside resistance was assessed in Stenotrophomonas maltophilia The clpA , clpS , clpP , and htpX genes were upregulated in response to kanamycin exposure. Of them, clpA and htpX were the primary determinants responsible for intrinsic AG resistance. Inactivation of clpA and htpX compromised protease-mediated intrinsic aminoglycoside resistances and weakened SmeYZ pump-mediated aminoglycoside resistance, signifying HtpX and ClpA as potential AG adjuvant targets for treatment of S...
May 14, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29755435/analysis-of-phylogenetic-variation-of-stenotrophomonas-maltophilia-reveals-human-specific-branches
#6
Joerg Steinmann, Uwe Mamat, Ebrahim M Abda, Lisa Kirchhoff, Wolfgang R Streit, Ulrich E Schaible, Stefan Niemann, Thomas A Kohl
Stenotrophomonas maltophilia is a non-fermenting Gram-negative bacterium that is ubiquitous in the environment. In humans, this opportunistic multi-drug-resistant pathogen is responsible for a plethora of healthcare-associated infections. Here, we utilized a whole genome sequencing (WGS)-based phylogenomic core single nucleotide polymorphism (SNP) approach to characterize S. maltophilia subgroups, their potential association with human infection, and to detect any possible transmission events. In total, 89 isolates (67 clinical and 22 environmental) from Germany were sequenced...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29754971/stenotrophomonas-maltophilia
#7
Shi-Qi An, Gabriele Berg
This infographic describes the key regulated traits of Stenotrophomonas maltophilia, important for beneficial plant interactions, and also its increasing incidence as a nosocomial and community-acquired infection. Stenotrophomonas maltophilia is a cosmopolitan and ubiquitous bacterium found in a range of environmental habitats, including extreme ones, although in nature it is mainly associated with plants. S. maltophilia fulfils important ecosystem functions in the sulfur and nitrogen cycles, in degradation of complex compounds and pollutants, and in promoti on of plant growth and health...
May 10, 2018: Trends in Microbiology
https://www.readbyqxmd.com/read/29748104/stenotrophomonas-maltophilia-a-rare-case-of-osteomyelitis-after-an-open-distal-tibial-fracture
#8
Edward J Chesnutis, Alan Ng, Dustin Kruse, Paul A Stone
Stenotrophomonas maltophilia is a gram-negative rod rarely associated with osteomyelitis. To date, only 3 cases of osteomyelitis due to this pathogen have been previously referenced. We describe the case of a 77-year-old male who developed osteomyelitis secondary to S. maltophilia infection after an open distal tibial fracture sustained by falling off a ladder. The purpose of the present case report was to highlight this highly resistant microbe as an infectious etiology.
May 7, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29740543/quorum-sensing-signaling-and-quenching-in-the-multidrug-resistant-pathogen-stenotrophomonas-maltophilia
#9
REVIEW
Pol Huedo, Xavier Coves, Xavier Daura, Isidre Gibert, Daniel Yero
Stenotrophomonas maltophilia is an opportunistic Gram-negative pathogen with increasing incidence in clinical settings. The most critical aspect of S. maltophilia is its frequent resistance to a majority of the antibiotics of clinical use. Quorum Sensing (QS) systems coordinate bacterial populations and act as major regulatory mechanisms of pathogenesis in both pure cultures and poly-microbial communities. Disruption of QS systems, a phenomenon known as Quorum Quenching (QQ), represents a new promising paradigm for the design of novel antimicrobial strategies...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29738230/superior-bio-inert-capability-of-zwitterionic-poly-4-vinylpyridine-propylsulfobetaine-withstanding-clinical-sterilization-for-extended-medical-applications
#10
Antoine Venault, Min-Wen Lai, Jheng-Fong Jhong, Chih-Chen Yeh, Lu-Chen Yeh, Yung Chang
The field of bio-inert materials is relatively mature as unique molecular designs for antifouling have been regularly presented over the past 30 years. However, the effect of steam sterilization, a common procedure in hospitals for sterilizing biomedical devices in clinical uses, on the stability of antifouling and hemocompatible biomaterials remains unexplored. The only available set of data indicates that poly(sulfobetaine methacrylate) (SBMA) is unstable and loses its antifouling properties when exposed to hot humid air, depriving it of its attractiveness...
May 8, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29728008/the-action-of-chemical-and-mechanical-stresses-on-single-and-dual-species-biofilm-removal-of-drinking-water-bacteria
#11
I B Gomes, M Lemos, L Mathieu, M Simões, L C Simões
The presence of biofilms in drinking water distribution systems (DWDS) is a global public health concern as they can harbor pathogenic microorganisms. Sodium hypochlorite (NaOCl) is the most commonly used disinfectant for microbial growth control in DWDS. However, its effect on biofilm removal is still unclear. This work aims to evaluate the effects of the combination of chemical (NaOCl) and mechanical stresses on the removal of single and dual species biofilms of two bacteria isolated from DWDS and considered opportunistic, Acinectobacter calcoaceticus and Stenotrophomonas maltophilia...
August 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29726742/isolation-and-characterization-of-novel-bacterial-strain-present-in-a-lab-scale-hybrid-uasb-reactor-treating-distillery-spent-wash
#12
R Thiyagu, P Sivarajan
Recalcitrant compounds degrading novel bacteria was isolated from lab scale hybrid UASB reactor treating distillery spent wash, enriched with biomass activity. The granules were subjected to SEM analysis to classify and isolate the bacterial strains. The strain was ubiquitous, mesophilic, gram-negative, motile, non-spore forming and cultivable optimally at 30°C at pH 7. Most potential isolates from the strains were subjected to 16S rRNA sequencing and branded as a member of diverse genera, gamma-proteobacteria, Stenotrophomonas sp...
May 4, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29725253/anti-biofilm-and-anti-virulence-efficacy-of-celastrol-against-stenotrophomonas-maltophilia
#13
Hye-Rim Kim, Dongsup Lee, Yong-Bin Eom
Stenotrophomonas maltophilia is a multi-drug resistant opportunistic pathogen that causes nosocomial infections in immunocompromised patients. This pathogen is difficult to treat owing to its intrinsic multidrug resistance and ability to form antimicrobial-tolerant biofilms. In the present study, we aimed to assess the potential use of celastrol as a novel anti-biofilm and/or anti-virulence agent against S. maltophilia . Results showed that celastrol at its sub-inhibitory doses decreased biofilm formation and disrupt the established biofilms produced by S...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29673561/risk-factors-for-death-from-stenotrophomonas-maltophilia-bacteremia
#14
Kayo Osawa, Katsumi Shigemura, Koichi Kitagawa, Issei Tokimatsu, Masato Fujisawa
PURPOSE: Stenotrophomonas maltophilia has low pathogenicity potential, but if it causes bacteremia it can be fatal, because it has shown high resistance to many antibiotics and can be difficult to treat. Patient death from S. maltophilia bacteremia has increased since 2014 in our hospital. In this study, we investigated risk factors for death due to S. maltophilia bacteremia. METHODS: Seventy patients from the hospital database with S. maltophilia bacteremia between January 2010 and July 2017 were investigated...
April 16, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29663550/bacterial-community-structure-and-diversity-in-the-gut-of-muga-silkworm-antheraea-assamensis-lepidoptera-saturniidae-from-india
#15
Sakshi Gandotra, Archna Kumar, Kailash Naga, Pinky Moni Bhuyan, Dip K Gogoi, Kirti Sharma, Sabtharishi Subramanian
Muga silkworm, Antheraea assamensis is exclusively present in the North Eastern regions of India and rearing of this silkworm is a vocation unique to this region in the world. Through culture dependent techniques, generic identification using 16s rRNA probes, diversity analysis and qualitative screening for enzyme activities, our studies have identified a number of bacterial isolates viz., Bacillus spp, Serratia marcescens, Stenotrophomonas maltophilia, Pseudomonas stutzeri, Acinetobacter sp. and Alcaligens sp...
April 17, 2018: Insect Molecular Biology
https://www.readbyqxmd.com/read/29611898/acanthamoeba-s13wt-relies-on-its-bacterial-endosymbiont-to-backpack-human-pathogenic-bacteria-and-resist-legionella-infection-on-solid-media
#16
Torahiko Okubo, Mizue Matsushita, Shinji Nakamura, Junji Matsuo, Hiroki Nagai, Hiroyuki Yamaguchi
Soil-borne amoeba Acanthamoeba S13WT has an endosymbiotic relationship with an environmental Neochlamydia bacterial strain. However, regardless of extensive experiments in liquid media, the biological advantage of the symbiosis remained elusive. We therefore explored the role of the endosymbiont in predator-prey interactions on solid media. A mixed culture of the symbiotic or aposymbiotic amoebae and GFP-expressing Escherichia coli or Salmonella Enteritidis was spotted onto the center of a LB or B-CYE agar plate pre-inoculated with a ring of mCherry-expressing Legionella pneumophila (Legionella "wall")...
April 3, 2018: Environmental Microbiology Reports
https://www.readbyqxmd.com/read/29610195/overexpression-of-the-efflux-pumps-smevwx-and-smedef-is-a-major-cause-of-resistance-to-cotrimoxazole-in-stenotrophomonas-maltophilia
#17
María Blanca Sánchez, José Luis Martínez
Cotrimoxazole is one of the antimicrobials of choice for treating Stenotrophomonas maltophilia infections. Most works on the molecular epidemiology of resistance to this drugs combination are based in the analysis of sul genes. Nevertheless, the existence of clinical cotrimoxazole resistant S. maltophilia isolates that do not harbor sul genes has been reported. To investigate potential mutations that can reduce the susceptibility of S. maltophilia to cotrimoxazole, spontaneous S. maltophilia cotrimoxazole resistant mutants isolated under different cotrimoxazole concentrations were studied...
April 2, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29609854/residual-moisture-and-waterborne-pathogens-inside-flexible-endoscopes-evidence-from-a-multisite-study-of-endoscope-drying-effectiveness
#18
Cori L Ofstead, Otis L Heymann, Mariah R Quick, John E Eiland, Harry P Wetzler
BACKGROUND: Endoscopy-associated infection transmission is frequently linked to inadequate reprocessing. Residual organic material and moisture may foster biofilm development inside endoscopes. This study evaluated the effectiveness of endoscope drying and storage methods and assessed associations between retained moisture and contamination. METHODS: Endoscope reprocessing, drying, and storage practices were assessed at 3 hospitals. Researchers performed visual examinations and tests to detect fluid and contamination on patient-ready endoscopes...
March 30, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29605188/utility-of-maldi-tof-ms-in-an-outbreak-investigation-of-acute-endophtalmitis-following-intra-vitreal-injection
#19
Archana Angrup, Sivanantham Krishnamoorthi, Manisha Biswal, Vikas Gautam, Pallab Ray, Aniruddha Agarwal, M R Dogra, Ramandeep Singh, Deeksha Katoch, Vishali Gupta
Bevacizumab, a recombinant humanized monoclonal antibody to inhibit tumour-angiogenesis is available for off-label use for treating choroidal neovascularisation. Outbreaks have been reported after use of this drug, either because of contamination during manufacturing or the practice of multiple doses being administered from a single vial to different patients. In our institute we investigated one endopthalmitis outbreak following intra-vitreal injection of Bevacizumab, rapidly identified the Stenotrophomonas maltophilia as the causative agent and established the contaminated bevacizumab vial as the source using MALDI-TOF-MS typing...
March 29, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29575970/medical-management-of-endocarditis-caused-by-stenotrophomonas-maltophilia-a-case-report
#20
Sunish Shah, Madeline King, Lucia Rose
A 44-year-old female was found to be systemically ill at dialysis and admitted to the hospital. Days into the hospitalization, her blood cultures from dialysis were positive with Stenotrophomonas maltophilia bacteremia with a levofloxacin minimum inhibitory concentration (MIC) of 1. She was discharged on ciprofloxacin 500 mg orally (PO) daily on hospital day 2 to complete a 14-day course. Weeks later, she was again found to be bacteremic at dialysis and sent back to the hospital. She was started on empiric antibiotics upon admission until further identification...
January 1, 2018: Journal of Pharmacy Practice
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