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stenotrophomonas maltophilia

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https://www.readbyqxmd.com/read/28924135/reply-to-the-difficulty-in-administering-appropriate-antimicrobial-therapy-for-stenotrophomonas-maltophilia-bacteremia
#1
Hirotaka Ebara, Hideharu Hagiya, Yuto Haruki, Eisei Kondo, Fumio Otsuka
No abstract text is available yet for this article.
September 15, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28924133/the-difficulty-in-administering-appropriate-antimicrobial-therapy-for-stenotrophomonas-maltophilia-bacteremia
#2
Mitsuru Yanai, Yoshinori Inagaki, Tomohiko Tokunaga
No abstract text is available yet for this article.
September 15, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28912755/editorial-a-multidisciplinary-look-at-stenotrophomonas-maltophilia-an-emerging-multi-drug-resistant-global-opportunistic-pathogen
#3
EDITORIAL
Joanna S Brooke, Giovanni Di Bonaventura, Gabriele Berg, José-Luis Martinez
No abstract text is available yet for this article.
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28902008/fibrous-catalyst-enhanced-acanthamoeba-disinfection-by-hydrogen-peroxide
#4
Simon Kilvington, Lynn Winterton
SIGNIFICANCE: Hydrogen peroxide (H2O2) disinfection systems are contact-lens-patient problem solvers. The current one-step, criterion-standard version has been widely used since the mid-1980s, without any significant improvement. This work identifies a potential next-generation, one-step H2O2, not based on the solution formulation but rather on a case-based peroxide catalyst. PURPOSE: One-step H2O2 systems are widely used for contact lens disinfection. However, antimicrobial efficacy can be limited because of the rapid neutralization of the peroxide from the catalytic component of the systems...
September 9, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28894437/evolution-of-stenotrophomonas-maltophilia-in-cystic-fibrosis-lung-over-chronic-infection-a-genomic-and-phenotypic-population-study
#5
Alfonso Esposito, Arianna Pompilio, Clotilde Bettua, Valentina Crocetta, Elisabetta Giacobazzi, Ersilia Fiscarelli, Olivier Jousson, Giovanni Di Bonaventura
Stenotrophomonas maltophilia has been recognized as an emerging multi-drug resistant opportunistic pathogen in cystic fibrosis (CF) patients. We report a comparative genomic and phenotypic analysis of 91 S. maltophilia strains from 10 CF patients over a 12-year period. Draft genome analyses included in silico Multi-Locus Sequence Typing (MLST), Single-Nucleotide Polymorphisms (SNPs), and pangenome characterization. Growth rate, biofilm formation, motility, mutation frequency, in vivo virulence, and in vitro antibiotic susceptibility were determined and compared with population structure over time...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28894400/a-combination-of-trimethoprim-sulfamethoxazole-and-ceftazidime-showed-good-in-vitro-activity-against-stenotrophomonas-maltophilia
#6
Nabilah Ismail, Zarifah Zam, Siti Asma Hassan, Zaidah Abdul Rahman
BACKGROUND: Stenotrophomonas maltophilia has emerged as an important nosocomial pathogen, capable of causing a wide spectrum of infections. Treatment is difficult because it is resistant to many antimicrobial agents, thus reducing the treatment options. The aims of this study were to describe the antimicrobial susceptibility patterns and synergistic effect of selected antimicrobial combinations against S. maltophilia isolates. METHODS: This was a descriptive cross-sectional study undertaken in the Hospital Universiti Sains Malaysia from April 2011 to March 2012...
March 2017: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/28893914/stenotrophomonas-maltophilia-serine-protease-stmpr1-induces-matrilysis-anoikis-and-protease-activated-receptor-2-activation-in-human-lung-epithelial-cells
#7
Ashley L DuMont, Nicholas P Cianciotto
Stenotrophomonas maltophilia is an emerging, opportunistic nosocomial pathogen that can cause severe disease in immunocompromised individuals. We recently identified the StmPr1 and StmPr2 serine proteases as substrates of the Xps type II secretion system in S. maltophilia strain K279a. Here, we report that a third serine protease, StmPr3, is also secreted in an Xps-dependent manner. By constructing a panel of protease mutants in strain K279s, we were able to determine that StmPr3 contributes to the previously described Xps-mediated rounding and detachment of the A549 human lung epithelial cell line as well as Xps-mediated degradation of fibronectin, fibrinogen, and the cytokine interleukin-8...
September 11, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28876489/structural-mechanistic-insights-into-the-efficacy-of-non-classical-%C3%AE-lactamase-inhibitors-against-extensively-drug-resistant-stenotrophomonas-maltophilia-clinical-isolates
#8
Karina Calvopiña, Philip Hinchliffe, Jürgen Brem, Kate J Heesom, Samar Johnson, Ricky Cain, Christopher T Lohans, Colin W G Fishwick, Christopher J Schofield, James Spencer, Matthew B Avison
Clavulanic acid and avibactam are clinically deployed serine β-lactamase inhibitors, important as a defence against antibacterial resistance. Bicyclic boronates are recently discovered inhibitors of serine and some metallo β-lactamases. Here we show that avibactam and a bicyclic boronate inhibit L2 (serine β-lactamase) but not L1 (metallo β-lactamase) from the extensively drug resistant human pathogen Stenotrophomonas maltophilia. X-ray crystallography revealed that both inhibitors bind L2 by covalent attachment to the nucleophilic serine...
September 6, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28861525/impacts-of-penicillin-binding-protein-2-inactivation-on-%C3%AE-lactamase-expression-and-muropeptide-profile-in-stenotrophomonas-maltophilia
#9
Yi-Wei Huang, Yu Wang, Yun Lin, Chin Lin, Yi-Tsung Lin, Cheng-Chih Hsu, Tsuey-Ching Yang
Penicillin binding proteins (PBPs) are involved in peptidoglycan synthesis, and their inactivation is linked to β-lactamase expression in ampR-β-lactamase module-harboring Gram-negative bacteria. There are seven annotated PBP genes, namely, mrcA, mrcB, pbpC, mrdA, ftsI, dacB, and dacC, in the Stenotrophomonas maltophilia genome, and these genes encode PBP1a, PBP1b, PBP1c, PBP2, PBP3, PBP4, and PBP6, respectively. In addition, S. maltophilia harbors two β-lactamase genes, L1 and L2, whose expression is induced via β-lactam challenge...
July 2017: MSystems
https://www.readbyqxmd.com/read/28861062/evolutionary-genetic-analysis-uncovers-multiple-species-with-distinct-habitat-preferences-and-antibiotic-resistance-phenotypes-in-the-stenotrophomonas-maltophilia-complex
#10
Luz E Ochoa-Sánchez, Pablo Vinuesa
The genus Stenotrophomonas (Gammaproteobacteria) has a broad environmental distribution. Stenotrophomonas maltophilia is its best known species because it is a globally emerging, multidrug-resistant (MDR), opportunistic pathogen. Members of this species are known to display high genetic, ecological and phenotypic diversity, forming the so-called S. maltophilia complex (Smc). Heterogeneous resistance and virulence phenotypes have been reported for environmental Smc isolates of diverse ecological origin. We hypothesized that this heterogeneity could be in part due to the potential lumping of several cryptic species in the Smc...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28840460/synthesis-of-chitin-oligosaccharides-using-dried-stenotrophomonas-maltophilia-cells-containing-a-transglycosylation-reaction-catalyzing-%C3%AE-n-acetylhexosaminidase-as-a-whole-cell-catalyst
#11
Asaki Uehara, Narumi Takahashi, Mei Moriyama, Takako Hirano, Wataru Hakamata, Toshiyuki Nishio
Bacterial strain NYT501, which we previously isolated from soil, was identified as Stenotrophomonas maltophilia, and it was confirmed that this strain produces an intracellular β-N-acetylhexosaminidase exhibiting transglycosylation activity. Several properties of this enzyme were characterized using a partially purified enzyme preparation. Using N,N'-diacetylchitobiose (GlcNAc)2 and N,N',N″-triacetylchitotriose (GlcNAc)3 as substrates and dried cells of this bacterium as a whole-cell catalyst, chitin oligosaccharides of higher degrees of polymerization were synthesized...
August 24, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28837770/background-nutrients-affect-the-biotransformation-of-tetracycline-by-stenotrophomonas-maltophilia-as-revealed-by-genomics-and-proteomics
#12
Yifei Leng, Jianguo Bao, Dandan Song, Jing Li, Mao Ye, Xu Li
Certain bacteria are resistant to antibiotics and can even transform antibiotics in the environment. It is unclear how the molecular mechanisms underlying the resistance and biotransformation processes vary under different environmental conditions. The objective of this study is to investigate the molecular mechanisms of tetracycline resistance and biotransformation by Stenotrophomonas maltophilia strain DT1 under various background nutrient conditions. Strain DT1 was exposed to tetracycline for 7 days with four background nutrient conditions: no background (NB), peptone (P), peptone plus citrate (PC), and peptone plus glucose (PG)...
September 11, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28821244/the-effect-of-dietary-bacterial-organic-selenium-on-growth-performance-antioxidant-capacity-and-selenoproteins-gene-expression-in-broiler-chickens
#13
A M Dalia, T C Loh, A Q Sazili, M F Jahromi, A A Samsudin
BACKGROUND: Selenium (Se) is an essential trace mineral in broilers, which has several important roles in biological processes. Organic forms of Se are more efficient than inorganic forms and can be produced biologically via Se microbial reduction. Hence, the possibility of using Se-enriched bacteria as feed supplement may provide an interesting source of organic Se, and benefit broiler antioxidant system and other biological processes. The objective of this study was to examine the impacts of inorganic Se and different bacterial organic Se sources on the performance, serum and tissues Se status, antioxidant capacity, and liver mRNA expression of selenoproteins in broilers...
August 18, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28820086/stenotrophomonas-bentonitica-sp-nov-isolated-from-bentonite-formations
#14
Iván Sánchez-Castro, Miguel Angel Ruiz-Fresneda, Mohammed Bakkali, Peter Kämpfer, Stefanie P Glaeser, Hans Jürgen Busse, Margarita López-Fernández, Pablo Martínez-Rodríguez, Mohamed Larbi Merroun
A Gram-stain negative, rod-shaped, aerobic bacterial strain, BII-R7T, was isolated during a study targeting the culture-dependent microbial diversity occurring in bentonite formations from southern Spain. Comparative 16S rRNA gene sequence analysis showed that BII-R7T represented a member of the genus Stenotrophomonas (class Gammaproteobacteria), and was related most closely to Stenotrophomonas rhizophila e-p10T (99.2 % sequence similarity), followed by Stenotrophomonas pavanii ICB 89T (98.5 %), Stenotrophomonas maltophilia IAM 12423T, Stenotrophomonas chelatiphaga LPM-5T and Stenotrophomonas tumulicola T5916-2-1bT (all 98...
August 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28815999/incident-stenotrophomonas-maltophilia-infection-and-lung-function-decline-in-cystic-fibrosis
#15
Emily E Barsky, Kathryn A Williams, Gregory P Priebe, Gregory S Sawicki
OBJECTIVES: To determine whether incident detection of Stenotrophomonas maltophilia (SM) in patients with cystic fibrosis (CF) is associated with accelerated lung function decline and increased hospitalizations and to determine whether this effect is more pronounced in individuals with subsequent chronic infection. METHODS: We performed a longitudinal, retrospective single-center, pre-post study of 88 patients with CF, ages 6-51 years, with first positive respiratory culture for SM between 2008 and 2014...
August 16, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28810329/-distribution-and-drug-resistance-of-pathogens-at-hematology-department-of-jiangsu-province-from-2014-to-2015-results-from-a-multicenter-retrospective-study
#16
Y K Wan, W Sang, B Chen, Y G Yang, L Q Zhang, A N Sun, Y J Liu, Y Xu, Y P Cai, C B Wang, Y F Shen, Y W Jiang, X Y Zhang, W Xu, M Hong, T Chen, R R Xu, F Li, Y L Xu, Y Xue, Y L Lu, Z M He, W M Dong, Z Chen, M H Ji, Y Y Yang, L J Zhai, Y Zhao, G Q Wu, J H Ding, J Cheng, W B Cai, Y M Sun, J Ouyang
Objective: To describe the distribution and drug resistance of pathogens at hematology department of Jiangsu Province from 2014 to 2015 to provide reference for empirical anti-infection treatment. Methods: Pathogens were from hematology department of 26 tertiary hospitals in Jiangsu Province from 2014 to 2015. Antimicrobial susceptibility testing was carried out according to a unified protocol using Kirby-Bauer method or agar dilution method. Collection of drug susceptibility results and corresponding patient data were analyzed...
July 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/28782646/%C3%AE-lacta-%C3%A2-test-performance-for-detection-of-extended-spectrum-%C3%AE-lactamase-producing-gram-negative-bacilli-directly-on-bronchial-aspirates-samples-a-validation-study
#17
Salah Gallah, Yahia Benzarara, Jacques Tankovic, Paul-Louis Woerther, Hayat Bensekri, Jean-Luc Mainardi, Guillaume Arlet, Sophie Vimont, Marc Garnier
OBJECTIVES: Incidence of Extended Spectrum β-Lactamase-producing Gram Negative Bacilli (ESBL-P-GNB)-related infections is worryingly increasing worldwide. ESBL-P-GNB detection directly on bronchial aspirate samples (BAS) performed for suspected pneumonia may help save empirical carbapenems. Our objectives were to optimize β-LACTA(®) test (BLT) realization and evaluate BLT performance for ESBL-P-GNB detection directly on BAS. METHODS: 1) BLT technical optimization using BAS of different matrix types spiked with increasing concentrations of CTX-M-15-producing Klebsiella pneumoniae; 2) in vitro validation of BLT diagnostic performance on 17 ESBL enzymes, belonging to CTX-M, SHV, TEM, OXA, GES, VEB, and PER groups; 3) clinical validation of BLT performance on 126 BAS prospectively collected from 7 Intensive Care Units...
August 3, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28771141/risk-factors-and-molecular-mechanisms-associated-with-trimethoprim-sulfamethoxazole-resistance-in-stenotrophomonas-maltophilia-in-mexico
#18
Sandra Abril Herrera-Heredia, César Pezina-Cantú, Elvira Garza-González, Paola Bocanegra-Ibarias, Soraya Mendoza-Olazarán, Rayo Morfín-Otero, Adrián Camacho-Ortiz, Licet Villarreal-Treviño, Eduardo Rodríguez-Noriega, Laura Paláu-Davila, Héctor Jesús Maldonado-Garza, Samantha Flores-Treviño
PURPOSE: Stenotrophomonas maltophilia is a multidrug-resistant opportunistic pathogen causing an increasing number of nosocomial infections. Our aim was to evaluate the risk factors and mechanisms associated with trimethoprim-sulfamethoxazole (SXT) resistance in S. maltophilia infections in Mexico. METHODOLOGY: Clinical isolates and patients' demographic and clinical data were collected from February 2007 to August 2015 in two tertiary-care hospitals in Mexico. Antimicrobial susceptibility and analysis of sul and SmeABC and SmeDEF efflux pump overexpression were performed in all isolates...
August 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28771133/stenotrophomonas-maltophilia-is-highly-prevalent-among-houseflies-musca-domestica
#19
Akira Fukuda, Masaru Usui, Hideyuki Wakao, Chanchai Boonla, Yutaka Tamura
Stenotrophomonas maltophilia is capable of surviving in a wide variety of environments and is considered to be among the antimicrobial-resistant bacteria of greatest public health concern in hospital settings. To clarify the role of houseflies (Musca domestica) in disseminating this bacterium, we collected 99 individuals from 15 locations (9 farms and 6 urban areas) in Thailand. S. maltophilia was isolated from 39 % (39/99) of these houseflies, with the isolation rates being similar in farms and urban areas...
August 4, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28764775/an-assessment-on-the-role-of-endophytic-microbes-in-the-therapeutic-potential-of-fagonia-indica
#20
Lubna Rahman, Zabta K Shinwari, Irum Iqrar, Lutfur Rahman, Faouzia Tanveer
BACKGROUND: Natural products of animals, plants and microbes are potential source of important chemical compounds, with diverse applications including therapeutics. Endophytic bacteria that are especially associated with medicinal plants presents a reservoir of therapeutic compounds. Fagonia indica has been recently investigated by numerous researchers because of its striking therapeutic potential especially in cancer. It is also reported that endophytes play a vital role in the biosynthesis of various metabolites; therefore we believe that endophytes associated with F...
August 1, 2017: Annals of Clinical Microbiology and Antimicrobials
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