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https://www.readbyqxmd.com/read/28815999/incident-stenotrophomonas-maltophilia-infection-and-lung-function-decline-in-cystic-fibrosis
#1
Emily E Barsky, Kathryn A Williams, Gregory P Priebe, Gregory S Sawicki
OBJECTIVES: To determine whether incident detection of Stenotrophomonas maltophilia (SM) in patients with cystic fibrosis (CF) is associated with accelerated lung function decline and increased hospitalizations and to determine whether this effect is more pronounced in individuals with subsequent chronic infection. METHODS: We performed a longitudinal, retrospective single-center, pre-post study of 88 patients with CF, ages 6-51 years, with first positive respiratory culture for SM between 2008 and 2014...
August 16, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28810329/-distribution-and-drug-resistance-of-pathogens-at-hematology-department-of-jiangsu-province-from-2014-to-2015-results-from-a-multicenter-retrospective-study
#2
Y K Wan, W Sang, B Chen, Y G Yang, L Q Zhang, A N Sun, Y J Liu, Y Xu, Y P Cai, C B Wang, Y F Shen, Y W Jiang, X Y Zhang, W Xu, M Hong, T Chen, R R Xu, F Li, Y L Xu, Y Xue, Y L Lu, Z M He, W M Dong, Z Chen, M H Ji, Y Y Yang, L J Zhai, Y Zhao, G Q Wu, J H Ding, J Cheng, W B Cai, Y M Sun, J Ouyang
Objective: To describe the distribution and drug resistance of pathogens at hematology department of Jiangsu Province from 2014 to 2015 to provide reference for empirical anti-infection treatment. Methods: Pathogens were from hematology department of 26 tertiary hospitals in Jiangsu Province from 2014 to 2015. Antimicrobial susceptibility testing was carried out according to a unified protocol using Kirby-Bauer method or agar dilution method. Collection of drug susceptibility results and corresponding patient data were analyzed...
July 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/28782646/%C3%AE-lacta-%C3%A2-test-performance-for-detection-of-extended-spectrum-%C3%AE-lactamase-producing-gram-negative-bacilli-directly-on-bronchial-aspirates-samples-a-validation-study
#3
Salah Gallah, Yahia Benzarara, Jacques Tankovic, Paul-Louis Woerther, Hayat Bensekri, Jean-Luc Mainardi, Guillaume Arlet, Sophie Vimont, Marc Garnier
OBJECTIVES: Incidence of Extended Spectrum β-Lactamase-producing Gram Negative Bacilli (ESBL-P-GNB)-related infections is worryingly increasing worldwide. ESBL-P-GNB detection directly on bronchial aspirate samples (BAS) performed for suspected pneumonia may help save empirical carbapenems. Our objectives were to optimize β-LACTA(®) test (BLT) realization and evaluate BLT performance for ESBL-P-GNB detection directly on BAS. METHODS: 1) BLT technical optimization using BAS of different matrix types spiked with increasing concentrations of CTX-M-15-producing Klebsiella pneumoniae; 2) in vitro validation of BLT diagnostic performance on 17 ESBL enzymes, belonging to CTX-M, SHV, TEM, OXA, GES, VEB, and PER groups; 3) clinical validation of BLT performance on 126 BAS prospectively collected from 7 Intensive Care Units...
August 3, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28771141/risk-factors-and-molecular-mechanisms-associated-with-trimethoprim-sulfamethoxazole-resistance-in-stenotrophomonas-maltophilia-in-mexico
#4
Sandra Abril Herrera-Heredia, César Pezina-Cantú, Elvira Garza-González, Paola Bocanegra-Ibarias, Soraya Mendoza-Olazarán, Rayo Morfín-Otero, Adrián Camacho-Ortiz, Licet Villarreal-Treviño, Eduardo Rodríguez-Noriega, Laura Paláu-Davila, Héctor Jesús Maldonado-Garza, Samantha Flores-Treviño
PURPOSE: Stenotrophomonas maltophilia is a multidrug-resistant opportunistic pathogen causing an increasing number of nosocomial infections. Our aim was to evaluate the risk factors and mechanisms associated with trimethoprim-sulfamethoxazole (SXT) resistance in S. maltophilia infections in Mexico. METHODOLOGY: Clinical isolates and patients' demographic and clinical data were collected from February 2007 to August 2015 in two tertiary-care hospitals in Mexico. Antimicrobial susceptibility and analysis of sul and SmeABC and SmeDEF efflux pump overexpression were performed in all isolates...
August 4, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28771133/stenotrophomonas-maltophilia-is-highly-prevalent-among-houseflies-musca-domestica
#5
Akira Fukuda, Masaru Usui, Hideyuki Wakao, Chanchai Boonla, Yutaka Tamura
Stenotrophomonas maltophilia is capable of surviving in a wide variety of environments and is considered to be among the antimicrobial-resistant bacteria of greatest public health concern in hospital settings. To clarify the role of houseflies (Musca domestica) in disseminating this bacterium, we collected 99 individuals from 15 locations (9 farms and 6 urban areas) in Thailand. S. maltophilia was isolated from 39 % (39/99) of these houseflies, with the isolation rates being similar in farms and urban areas...
August 4, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28764775/an-assessment-on-the-role-of-endophytic-microbes-in-the-therapeutic-potential-of-fagonia-indica
#6
Lubna Rahman, Zabta K Shinwari, Irum Iqrar, Lutfur Rahman, Faouzia Tanveer
BACKGROUND: Natural products of animals, plants and microbes are potential source of important chemical compounds, with diverse applications including therapeutics. Endophytic bacteria that are especially associated with medicinal plants presents a reservoir of therapeutic compounds. Fagonia indica has been recently investigated by numerous researchers because of its striking therapeutic potential especially in cancer. It is also reported that endophytes play a vital role in the biosynthesis of various metabolites; therefore we believe that endophytes associated with F...
August 1, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28760634/tracking-the-spread-routes-of-opportunistic-premise-plumbing-pathogens-in-a-haematology-unit-with-water-points-of-use-protected-by-antimicrobial-filters
#7
Sophie Baranovsky, Estelle Jumas-Bilak, Anne Lotthé, Hélène Marchandin, Sylvie Parer, Yosr Hicheri, Sara Romano-Bertrand
BACKGROUND: Water networks in hospitals are frequently contaminated by Opportunistic Premise Plumbing Pathogens (OPPPs) leading to fitment of antimicrobial filters on water points-of-use (POU) in order to limit patients' exposure. AIM: to assess the spread of OPPPs through secondary water routes (outside the plumbing system) in an adult haematology unit in which 52 out of 73 water POU were high-risk for patients and protected by antimicrobial filters. METHODS: An observational audit identified 6 secondary water routes for which bacteria tracking and typing were performed in 315 surface samplings...
July 28, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28756169/public-health-and-healthcare-associated-risk-of-electric-warm-water-bidet-toilets
#8
Akiko Kanayama Katsuse, Hiroshi Takahashi, Sadako Yoshizawa, Kazuhiro Tateda, Yasuhiro Nakanishi, Akihiro Kaneko, Intetsu Kobayashi
BACKGROUND: In recent years, installation of bidet toilets within hospitals in Japan has raised concerns regarding potential for cross-contamination by antimicrobial resistant bacteria from patients who are hospitalized over an extended period. AIM: To investigate the distribution of antimicrobial resistant bacteria recovered from bidet toilets at a university-affiliated hospital in Japan. METHODS: All 292 electronic bidet toilets at a university hospital were sampled for contamination...
July 26, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28750627/air-pollution-exposure-is-associated-with-mrsa-acquisition-in-young-u-s-children-with-cystic-fibrosis
#9
Kevin J Psoter, Anneclaire J De Roos, Jon Wakefield, Jonathan D Mayer, Margaret Rosenfeld
BACKGROUND: The role of air pollution in increasing susceptibility to respiratory tract infections in the cystic fibrosis (CF) population has not been well described. We recently demonstrated that chronic PM2.5 exposure is associated with an increased risk of initial Pseudomonas aeruginosa acquisition in young children with CF. The purpose of this study was to determine whether PM2.5 exposure is a risk factor for acquisition of other respiratory pathogens in young children with CF. METHODS: We conducted a retrospective study of initial acquisition of methicillin susceptible and methicillin resistant Staphylococcus aureus (MSSA and MRSA), Stenotrophomonas maltophilia and Achromobacter xylosoxidans in U...
July 27, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28721477/imipenem-resistant-gram-negative-bacterial-isolates-carried-by-persons-upon-medical-examination-in-korea
#10
So Yeon Kim, Sang Yop Shin, Ji-Young Rhee, Kwan Soo Ko
Carbapenem-resistant Gram-negative bacteria (CR-GNB) have emerged and disseminated worldwide, become a great concern worldwide including Korea. The prevalence of fecal carriage of imipenem-resistant Gram-negative bacteria (IR-GNB) in persons in Korea was investigated. Stool samples were collected from 300 persons upon medical examination. Samples were screened for IR-GNB by using MacConkey agar with 2 μl/ml imipenem. Species were identified by 16S rRNA gene sequence analysis, and antimicrobial susceptibility was determined by the broth microdilution method...
August 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28706609/distribution-of-class-i-integron-and-smqnr-resistance-gene-among-stenotrophomonas-maltophilia-isolated-from-clinical-samples-in-iran
#11
Mohammadali Malekan, Bahman Tabaraie, Ladan Akhoundtabar, Parviz Afrough, Ava Behrouzi
BACKGROUND: Stenotrophomonas maltophilia (S. maltophilia) is a multiple-antibiotic-resistant opportunistic pathogen that is being isolated with increasing frequency from patients with health-care-associated infections. S. maltophilia is inherently resistant to most of the available antimicrobial agents. Spread of resistant strains has been attributed, in part, to class I integrons. In vitro susceptibility studies have shown trimethoprim-sulfamethoxazole and new floroquinolones as two important agents with activity against these organisms...
July 2017: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/28703780/in-vitro-and-in-vivo-control-of-secondary-bacterial-infection-caused-by-leishmania-major
#12
Hany M Yehia, Ebtesam M Al-Olayan, Manal F El-Khadragy, Dina M Metwally
Bacterial infections of cutaneous leishmaniasis cause skin ulcers on mice, resulting in increased tissue deterioration, and these infections can be controlled with liquid allicin. To isolate and identify the incidences of real secondary bacterial infections in mice, we performed the current study by injecting mice (n = 50) with Leishmania major. L. major infections were initiated by an intramuscular injection of 0.1 mL Roswell Park Memorial Institute (RPMI 1640 media/mouse (10(7) promastigote/mL)). Scarring appeared 2-6 weeks after injection, and the bacteria were isolated from the skin ulcer tissues...
July 13, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28701159/bacterial-bloodstream-infections-in-a-tertiary-infectious-diseases-hospital-in-northern-vietnam-aetiology-drug-resistance-and-treatment-outcome
#13
Vu Quoc Dat, Hieu Ngoc Vu, Hung Nguyen The, Hoa Thi Nguyen, Long Bao Hoang, Dung Vu Tien Viet, Chi Linh Bui, Kinh Van Nguyen, Trung Vu Nguyen, Dao Tuyet Trinh, Alessandro Torre, H Rogier van Doorn, Behzad Nadjm, Heiman F L Wertheim
BACKGROUND: Bloodstream infections (BSIs) are associated with high morbidity and mortality worldwide. However their aetiology, antimicrobial susceptibilities and associated outcomes differ between developed and developing countries. Systematic data from Vietnam are scarce. Here we present aetiologic data on BSI in adults admitted to a large tertiary referral hospital for infectious diseases in Hanoi, Vietnam. METHODS: A retrospective study was conducted at the National Hospital for Tropical Diseases between January 2011 and December 2013...
July 12, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28688829/risk-factors-for-hospital-acquisition-of-trimethoprim-sulfamethoxazole-resistant-stenotrophomonas-maltophilia-in-adults-a-matched-case-control-study
#14
Ching-Hsun Wang, Jung-Chung Lin, Feng-Yee Chang, Ching-Mei Yu, Wei-San Lin, Kuo-Ming Yeh
BACKGROUND/PURPOSE: The emergence of trimethoprim-sulfamethoxazole resistant Stenotrophomonas maltophilia (TSRSM) represents a serious threat to patients. The aim of current study was to identify risk factors associated with hospital-acquired TSRSM occurrence in adult inpatients. METHODS: We conducted a matched case-control study in Tri-Service General Hospital, Taipei, Taiwan. From January 2014 through June 2015, case patients with TSRSM and control patients with trimethoprim-sulfamethoxazole susceptible S...
June 28, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28680041/bsmr-degrades-c-di-gmp-to-modulate-biofilm-formation-of-nosocomial-pathogen-stenotrophomonas-maltophilia
#15
Wei Liu, Xiu-Qi Tian, Jin-Wei Wei, Li-Li Ding, Wei Qian, Zhong Liu, Fang-Fang Wang
c-di-GMP is a cellular second messenger that regulates diverse bacterial processes, including swimming, biofilm formation and virulence. However, in Stenotrophomonas maltophilia, a nosocomial pathogen that frequently infects immunodeficient or immunoincompetent patients, the regulatory function of c-di-GMP remains unclear. Here we show that BsmR is a negative regulator of biofilm development that degrades c-di-GMP through its EAL domain. Increasing BsmR expression resulted in significant increase in bacterial swimming and decrease in cell aggregation...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28674688/d-bmap18-antimicrobial-peptide-is-active-in-vitro-resists-to-pulmonary-proteases-but-loses-its-activity-in-a-murine-model-of-pseudomonas-aeruginosa-lung-infection
#16
Mario Mardirossian, Arianna Pompilio, Margherita Degasperi, Giulia Runti, Sabrina Pacor, Giovanni Di Bonaventura, Marco Scocchi
The spread of antibiotic resistant-pathogens is driving the search for new antimicrobial compounds. Pulmonary infections experienced by cystic fibrosis (CF) patients are a dramatic example of this health-care emergency. Antimicrobial peptides could answer the need for new antibiotics but translating them from basic research to the clinic is a challenge. We have previously evaluated the potential of the small membranolytic peptide BMAP-18 to treat CF-related infections, discovering that while this molecule had a good activity in vitro it was not active in vivo because of its rapid degradation by pulmonary proteases...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/28669016/co-infection-of-pseudomonas-aeruginosa-and-stenotrophomonas-maltophilia-in-hospitalised-pneumonia-patients-has-a-synergic-and-significant-impact-on-clinical-outcomes
#17
C Yin, W Yang, J Meng, Y Lv, J Wang, B Huang
Ventilator-acquired pneumonia and hospital community-acquired pneumonia are frequently caused by Gram-negative and -positive bacteria. We noted that pneumonia patients with co-infection of Pseudomonas aeruginosa and Stenotrophomonas maltophilia had a poor clinical outcome. To verify this, we retrospectively reviewed pneumonia cases at Hebei General Hospital from 2010 to 2015. These cases were grouped into four categories: (1) co-infection with P. aeruginosa and S. maltophilia, (2) infection with P. aeruginosa, (3) infection with S...
July 1, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28666755/activity-of-innate-antimicrobial-peptides-and-ivacaftor-against-clinical-cystic-fibrosis-respiratory-pathogens
#18
Joanna E Payne, Alice V Dubois, Rebecca J Ingram, Sinead Weldon, Clifford C Taggart, J Stuart Elborn, Michael M Tunney
There is a clear need for new antimicrobials to improve current treatment of chronic lung infection in people with cystic fibrosis (CF). This study determined the activities of antimicrobial peptides (AMPs) and ivacaftor, a novel CF transmembrane conductance regulator potentiator, for CF treatment. Antimicrobial activities of AMPs [LL37, human β-defensins (HβD) 1-4 and SLPI] and ivacaftor against clinical respiratory isolates (Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus spp., Achromobacter spp...
June 27, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28652234/meropenem-vaborbactam-tested-against-contemporary-gram-negative-isolates-collected-worldwide-during-2014-including-carbapenem-resistant-kpc-producing-multidrug-resistant-and-extensively-drug-resistant-enterobacteriaceae
#19
Mariana Castanheira, Michael D Huband, Rodrigo E Mendes, Robert K Flamm
We evaluated the activity of meropenem-vaborbactam against contemporary non-fastidious gram-negative clinical isolates, including resistant phenotypes and carbapenemase genotypes of Enterobacteriaceae Meropenem-vaborbactam (inhibitor at 8 μg/ml) and comparators were susceptibility tested using reference broth microdilution methods against 14,304 gram-negative clinical isolates collected worldwide during 2014. Carbapenemase encoding genes were screened by PCR/sequencing. Meropenem-vaborbactam (MIC50/90, ≤0...
June 26, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28648289/enteric-bacteria-of-food-ice-and-their-survival-in-alcoholic-beverages-and-soft-drinks
#20
Raimondo Gaglio, Nicola Francesca, Rosalia Di Gerlando, Jennifer Mahony, Simone De Martino, Carlo Stucchi, Giancarlo Moschetti, Luca Settanni
This study aimed to evaluate the levels of enteric bacteria in ice cubes produced in different environments (home-made, prepared in bars and pubs with ice machines and produced in industrial plants) and to determine their survival in different alcoholic beverages and soft drinks. Members of the Enterobacteriaceae family were found in almost all samples analysed. All industrial and the majority of home-made samples did not contain coliforms. Enterococci were not identified in domestic samples while they were detected in two industrial and three bar/pub samples...
October 2017: Food Microbiology
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