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Tilmanocept

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https://www.readbyqxmd.com/read/26924502/the-inextricable-axis-of-targeted-diagnostic-imaging-and-therapy-an-immunological-natural-history-approach
#1
REVIEW
Frederick O Cope, Bonnie Abbruzzese, James Sanders, Wendy Metz, Kristyn Sturms, David Ralph, Michael Blue, Jane Zhang, Paige Bracci, Wiam Bshara, Spencer Behr, Toby Maurer, Kenneth Williams, Joshua Walker, Allison Beverly, Brooke Blay, Anirudh Damughatla, Mark Larsen, Courtney Mountain, Erin Neylon, Kaeli Parcel, Kapil Raghuraman, Kevin Ricks, Lucas Rose, Akhilesh Sivakumar, Nicholas Streck, Bryan Wang, Christopher Wasco, Amifred Williams, Michael McGrath
In considering the challenges of approaches to clinical imaging, we are faced with choices that sometimes are impacted by rather dogmatic notions about what is a better or worse technology to achieve the most useful diagnostic image for the patient. For example, is PET or SPECT most useful in imaging any particular disease dissemination? The dictatorial approach would be to choose PET, all other matters being equal. But is such a totalitarian attitude toward imaging selection still valid? In the face of new receptor targeted SPECT agents one must consider the remarkable specificity and sensitivity of these agents...
March 2016: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/26320812/a-tri-modal-molecular-imaging-agent-for-sentinel-lymph-node-mapping
#2
Zhengtao Qin, Carl K Hoh, David J Hall, David R Vera
INTRODUCTION: We report an "instant kit" method to radiolabel fluorescent-tilmanocept with (68)Ga and (99m)Tc for tri-modal molecular imaging of sentinel lymph nodes (SLNs). METHODS: Solutions of sodium acetate, (68)GaCl(3) and Na(99m)TcO(4) were added successively to a "kit vial" containing lyophilized 800CW-tilmanocept, SnCl(2), trehalose and ascorbic acid. After a 30-min incubation, the pH was neutralized with PBS. No purification was required. Radiochemical and fluorescence purity was measured by HPLC and ITLC techniques...
December 2015: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/26275779/comparison-of-post-injection-site-pain-between-technetium-sulfur-colloid-and-technetium-tilmanocept-in-breast-cancer-patients-undergoing-sentinel-lymph-node-biopsy
#3
RANDOMIZED CONTROLLED TRIAL
Jonathan T Unkart, Jennifer L Baker, Ava Hosseini, Carl K Hoh, Mark S Wallace, David R Vera, Anne M Wallace
BACKGROUND: No prior studies have examined injection pain associated with Technetium-99m Tilmanocept (TcTM). METHODS: This was a randomized, double-blinded study comparing postinjection site pain between filtered Technetium Sulfur Colloid (fTcSC) and TcTM in breast cancer lymphoscintigraphy. Pain was evaluated with a visual analogue scale (VAS) (0-100 mm) and the short-form McGill Pain Questionnaire (SF-MPQ). The primary endpoint was mean difference in VAS scores at 1-min postinjection between fTcSC and TcTM...
December 2015: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/26202986/%C3%AE-tilmanocept-a-new-radiopharmaceutical-tracer-for-cancer-sentinel-lymph-nodes-binds-to-the-mannose-receptor-cd206
#4
Abul K Azad, Murugesan V S Rajaram, Wendy L Metz, Frederick O Cope, Michael S Blue, David R Vera, Larry S Schlesinger
γ-Tilmanocept ((99m)Tc-labeled-tilmanocept or [(99m)Tc]-tilmanocept) is the first mannose-containing, receptor-directed, radiolabeled tracer for the highly sensitive imaging of sentinel lymph nodes in solid tumor staging. To elucidate the mannose-binding receptor that retains tilmanocept in this microenvironment, human macrophages were used that have high expression of the C-type lectin mannose receptor (MR; CD206). Cy3-labeled tilmanocept exhibited high specificity binding to macrophages that was nearly abolished in competitive inhibition experiments...
September 1, 2015: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/25956693/99mtc-tilmanocept-a-novel-molecular-agent-for-lymphatic-mapping-and-sentinel-lymph-node-localization
#5
REVIEW
Devaki Shilpa Surasi, Janis O'Malley, Pradeep Bhambhvani
Preoperative lymphatic mapping in conjunction with intraoperative γ-probe detection is widely used for sentinel node localization in melanoma, breast cancer, and other malignancies. (99m)Tc-radiocolloids have been the standard radiotracers used for sentinel node mapping. (99m)Tc-tilmanocept is a receptor-binding molecular imaging agent approved by the U.S. Food and Drug Administration for lymphatic mapping and lymph node localization in breast cancer, melanoma, clinically node-negative squamous cell carcinoma of the oral cavity, and other solid tumors...
June 2015: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/25670018/-99m-tc-tilmanocept-accurately-detects-sentinel-lymph-nodes-and-predicts-node-pathology-status-in-patients-with-oral-squamous-cell-carcinoma-of-the-head-and-neck-results-of-a-phase-iii-multi-institutional-trial
#6
MULTICENTER STUDY
Amit Agrawal, Francisco J Civantos, Kevin T Brumund, Douglas B Chepeha, Nathan C Hall, William R Carroll, Russell B Smith, Robert P Zitsch, Walter T Lee, Yelizaveta Shnayder, David M Cognetti, Karen T Pitman, Dennis W King, Lori A Christman, Stephen Y Lai
BACKGROUND: [(99m)Tc]Tilmanocept, a novel CD206 receptor-targeted radiopharmaceutical, was evaluated in an open-label, phase III trial to determine the false negative rate (FNR) of sentinel lymph node biopsy (SLNB) relative to the pathologic nodal status in patients with intraoral or cutaneous head and neck squamous cell carcinoma (HNSCC) undergoing tumor resection, SLNB, and planned elective neck dissection (END). Negative predictive value (NPV), overall accuracy of SLNB, and the impact of radiopharmaceutical injection timing relative to surgery were assessed...
October 2015: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/25139676/robotic-assisted-fluorescence-sentinel-lymph-node-mapping-using-multimodal-image-guidance-in-an-animal-model
#7
Michael A Liss, Sean P Stroup, Zhengtao Qin, Carl K Hoh, David J Hall, David R Vera, Christopher J Kane
OBJECTIVE: To investigate positron emission tomography/computed tomography (PET/CT) preoperative imaging and intraoperative detection of a fluorescent-labeled receptor-targeted radiopharmaceutical in a prostate cancer animal model. MATERIALS AND METHODS: Three male beagle dogs underwent an intraprostatic injection of fluorescent-tagged tilmanocept, radiolabeled with both gallium Ga-68 and technetium Tc-99m. One hour after injection, a pelvic PET/CT scan was performed for preoperative sentinel lymph node (SLN) mapping...
October 2014: Urology
https://www.readbyqxmd.com/read/25069859/comparison-of-99m-tc-tilmanocept-and-filtered-99m-tc-sulfur-colloid-for-identification-of-slns-in-breast-cancer-patients
#8
COMPARATIVE STUDY
Jennifer L Baker, Minya Pu, Christopher A Tokin, Carl K Hoh, David R Vera, Karen Messer, Anne M Wallace
BACKGROUND: The efficacy of sentinel lymph node (SLN) surgery requires targeted removal of first-draining nodes; however, frequently more nodes are removed than necessary. [(99m)Tc]tilmanocept (TcTM) is a molecular-targeted radiopharmaceutical specifically designed for SLN mapping. We evaluated technical outcomes of SLN biopsy in breast cancer patients mapped with TcTM + vital blue dye (VBD) versus filtered [(99m)Tc]sulfur colloid (fTcSC) + VBD. METHODS: There were 84 versus 115 patients in the TcTM versus fTcSC cohorts, respectively...
January 2015: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/25028560/mapping-lymph-nodes-in-cancer-management-role-of-99m-tc-tilmanocept-injection
#9
REVIEW
Christoph Tausch, Astrid Baege, Christoph Rageth
Two decades ago, lymphatic mapping of sentinel lymph nodes (SLN) was introduced into surgical cancer management and was termed sentinel node navigated surgery. Although this technique is now routinely performed in the management of breast cancer and malignant melanoma, it is still under investigation for use in other cancers. The radioisotope technetium ((99m)Tc) and vital blue dyes are among the most widely used enhancers for SLN mapping, although near-infrared fluorescence imaging of indocyanine green is also becoming more commonly used...
2014: OncoTargets and Therapy
https://www.readbyqxmd.com/read/25024425/preclinical-evaluation-of-robotic-assisted-sentinel-lymph-node-fluorescence-imaging
#10
Michael A Liss, Salman Farshchi-Heydari, Zhengtao Qin, Sean A Hickey, David J Hall, Christopher J Kane, David R Vera
UNLABELLED: An ideal substance to provide convenient and accurate targeting for sentinel lymph node (SLN) mapping during robotic-assisted surgery has yet to be found. We used an animal model to determine the ability of the FireFly camera system to detect fluorescent SLNs after administration of a dual-labeled molecular imaging agent. METHODS: We injected the footpads of New Zealand White rabbits with 1.7 or 8.4 nmol of tilmanocept labeled with (99m)Tc and a near-infrared fluorophore, IRDye800CW...
September 2014: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/24923630/fluorescent-tilmanocept-for-tumor-margin-analysis-in-the-mouse-model
#11
Ava Hosseini, Jennifer L Baker, Christopher A Tokin, Zhengtao Qin, David J Hall, Dwayne G Stupak, Tomoko Hayashi, Anne M Wallace, David R Vera
BACKGROUND: Dendritic cells (DC) are localized in close proximity to cancer cells in many well-known tumors, and thus maybe a useful target for tumor margin assessment. MATERIALS AND METHODS: [(99m)Tc]- cyanine 7 (Cy7)-tilmanocept was synthesized and in vitro binding assays to bone marrow-derived DC were performed. Fifteen mice, implanted with either 4T1 mouse mammary or K1735 mouse melanoma tumors, were administered 1.0 nmol of [(99m)Tc]-Cy7-tilmanocept via tail vein injection...
August 2014: Journal of Surgical Research
https://www.readbyqxmd.com/read/24051744/use-of-a-novel-receptor-targeted-cd206-radiotracer-99mtc-tilmanocept-and-spect-ct-for-sentinel-lymph-node-detection-in-oral-cavity-squamous-cell-carcinoma-initial-institutional-report-in-an-ongoing-phase-3-study
#12
COMPARATIVE STUDY
Anna M Marcinow, Nathan Hall, Eric Byrum, Theodoros N Teknos, Matthew O Old, Amit Agrawal
IMPORTANCE: Sentinel lymph node biopsy has been proposed as an alternative to up-front elective neck dissection (END) for determination of pathologic nodal status in patients undergoing surgical treatment for oral cavity squamous cell carcinoma (OSCC) with clinically negative neck (cN0). Sentinel lymph node biopsy using current standard tracer agents and imaging adjuncts such as radiolabeled sulfur-colloid and planar lymphoscintigraphy (LS), however, is associated with several drawbacks...
September 2013: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/23958947/optimization-via-specific-fluorescence-brightness-of-a-receptor-targeted-probe-for-optical-imaging-and-positron-emission-tomography-of-sentinel-lymph-nodes
#13
Zhengtao Qin, David J Hall, Michael A Liss, Carl K Hoh, Christopher J Kane, Anne M Wallace, David R Vera
The optical properties of a receptor-targeted probe designed for dual-modality mapping of the sentinel lymph node (SLN) was optimized. Specific fluorescence brightness was used as the design criterion, which was defined as the fluorescence brightness per mole of the contrast agent. Adjusting the molar ratio of the coupling reactants, IRDye 800CW-NHS-ester and tilmanocept, enabled us to control the number of fluorescent molecules attached to each tilmanocept, which was quantified by H1 nuclear magnetic resonance spectroscopy...
October 2013: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/23504141/comparative-evaluation-of-99m-tc-tilmanocept-for-sentinel-lymph-node-mapping-in-breast-cancer-patients-results-of-two-phase-3-trials
#14
MULTICENTER STUDY
Anne M Wallace, Linda K Han, Stephen P Povoski, Kenneth Deck, Schlomo Schneebaum, Nathan C Hall, Carl K Hoh, Karl K Limmer, Helen Krontiras, Thomas G Frazier, Charles Cox, Eli Avisar, Mark Faries, Dennis W King, Lori Christman, David R Vera
BACKGROUND: Sentinel lymph node (SLN) surgery is used worldwide for staging breast cancer patients and helps limit axillary lymph node dissection. [(99m)Tc]Tilmanocept is a novel receptor-targeted radiopharmaceutical evaluated in 2 open-label, nonrandomized, within-patient, phase 3 trials designed to assess the lymphatic mapping performance. METHODS: A total of 13 centers contributed 148 patients with breast cancer. Each patient received [(99m)Tc]tilmanocept and vital blue dye (VBD)...
August 2013: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/23054107/combined-analysis-of-phase-iii-trials-evaluating-%C3%A2-%C3%A2-mtc-tilmanocept-and-vital-blue-dye-for-identification-of-sentinel-lymph-nodes-in-clinically-node-negative-cutaneous-melanoma
#15
COMPARATIVE STUDY
Vernon K Sondak, Dennis W King, Jonathan S Zager, Schlomo Schneebaum, Julian Kim, Stanley P L Leong, Mark B Faries, Bruce J Averbook, Steve R Martinez, Christopher A Puleo, Jane L Messina, Lori Christman, Anne M Wallace
BACKGROUND: [(99m)Tc]Tilmanocept is a CD206 receptor-targeted radiopharmaceutical designed for sentinel lymph node (SLN) identification. Two nearly identical nonrandomized phase III trials compared [(99m)Tc]tilmanocept to vital blue dye. METHODS: Patients received [(99m)Tc]tilmanocept and blue dye. SLNs identified intraoperatively as radioactive and/or blue were excised and histologically examined. The primary end point, concordance, was the proportion of blue nodes detected by [(99m)Tc]tilmanocept; 90 % concordance was the prespecified minimum concordance level...
February 2013: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/22753678/a-receptor-targeted-fluorescent-radiopharmaceutical-for-multireporter-sentinel-lymph-node-imaging
#16
Derek K Emerson, Karl K Limmer, David J Hall, Sung-Ho Han, William C Eckelman, Christopher J Kane, Anne M Wallace, David R Vera
PURPOSE: To determine the imaging and receptor-binding properties of a multireporter probe designed for sentinel lymph node (SLN) mapping via nuclear and fluorescence detection. MATERIALS AND METHODS: The animal experiments were approved by the institutional animal care and use committee. A multireporter probe was synthesized by covalently attaching cyanine 7 (Cy7), a near-infrared cyanine dye, to tilmanocept, a radiopharmaceutical that binds to a receptor specific to recticuloendothelial cells...
October 2012: Radiology
https://www.readbyqxmd.com/read/22729510/the-efficacy-of-tilmanocept-in-sentinel-lymph-mode-mapping-and-identification-in-breast-cancer-patients-a-comparative-review-and-meta-analysis-of-the-%C3%A2-%C3%A2-mtc-labeled-nanocolloid-human-serum-albumin-standard-of-care
#17
REVIEW
Christopher A Tokin, Frederick O Cope, Wendy L Metz, Michael S Blue, Beth M Potter, Bonnie C Abbruzzese, Richard D Hartman, Marcus T Joy, Dennis W King, Lori A Christman, David R Vera, Anne M Wallace
Sentinel lymph node (SLN) mapping is common, however question remains as to what the ideal imaging agent is and how such an agent might provide reliable and stable localization of SLNs. (99m)Tc-labeled nanocolloid human serum albumin (Nanocoll) is the most commonly used radio-labeled colloid in Europe and remains the standard of care (SOC). It is used in conjunction with vital blue dyes (VBDs) which relies on simple lymphatic drainage for localization. Although the exact mechanism of Nanocoll SLN localization is unknown, there is general agreement that Nanocoll exhibits the optimal size distribution and radiolabeling properties of the commercially available radiolabel colloids...
October 2012: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/22714690/preoperative-sentinel-lymph-node-mapping-of-the-prostate-using-pet-ct-fusion-imaging-and-ga-68-labeled-tilmanocept-in-an-animal-model
#18
Sean P Stroup, Christopher J Kane, Salman Farchshchi-Heydari, Claude M James, Christopher H Davis, Anne M Wallace, Carl K Hoh, David R Vera
Sentinel lymph node (SLN) identification with preoperative image guidance may improve pathological staging of prostate cancer by identifying nodes outside the standard template of dissection. Four anesthetized male dogs received an intra-prostatic injection of Ga-68-labeled tilmanocept. Every 20 min the pelvic lymph nodes were imaged using PET/CT fusion imaging. At 90 min post-injection a prostatectomy and extended lymphadenectomy were completed; ex vivo radioactivity was recorded for each node using a handheld gamma detector, and confirmed by calculation of percent-of-injected dose (%ID) via assay of Ga-68 radioactivity...
October 2012: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/21331809/a-phase-2-study-of-99m-tc-tilmanocept-in-the-detection-of-sentinel-lymph-nodes-in-melanoma-and-breast-cancer
#19
Stanley P L Leong, Julian Kim, Merrick Ross, Mark Faries, Charles R Scoggins, Wendy L Rich Metz, Frederick O Cope, Richard C Orahood
BACKGROUND: Several (99m)Tc-labeled agents that are not approved by the U.S. Food and Drug Administration are used for lymphatic mapping. A new low-molecular-weight mannose receptor-based, reticuloendothelial cell-directed, (99m)Tc-labeled lymphatic imaging agent, (99m)Tc-tilmanocept, was used for lymphatic mapping of sentinel lymph nodes (SLNs) from patients with primary breast cancer or melanoma malignancies. This novel molecular species provides the basis for potentially enhanced SLN mapping reliability...
April 2011: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/20873712/fast-18f-labeling-of-a-near-infrared-fluorophore-enables-positron-emission-tomography-and-optical-imaging-of-sentinel-lymph-nodes
#20
Richard Ting, Todd A Aguilera, Jessica L Crisp, David J Hall, William C Eckelman, David R Vera, Roger Y Tsien
We combine a novel boronate trap for F(-) with a near-infrared fluorophore into a single molecule. Attachment to targeting ligands enables localization by positron emission tomography (PET) and near-infrared fluorescence (NIRF). Our first application of this generic tag is to label Lymphoseek (tilmanocept), an agent designed for receptor-specific sentinel lymph node (SLN) mapping. The new conjugate incorporates (18)F(-) in a single, aqueous step, targets mouse SLN rapidly (1 h) with reduced distal lymph node accumulation, permits PET or scintigraphic imaging of SLN, and enables NIRF-guided excision and histological verification even after (18)F decay...
October 20, 2010: Bioconjugate Chemistry
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