Nicole J Gervais, Laura Gravelsins, Alana Brown, Rebekah Reuben, Laurice Karkaby, Elizabeth Baker-Sullivan, Leanne Mendoza, Claire Lauzon, Anne Almey, William D Foulkes, Marcus Q Bernardini, Michelle Jacobson, Lea Velsher, M Natasha Rajah, Rosanna K Olsen, Cheryl Grady, Gillian Einstein
The present study explored whether early midlife bilateral salpingo-oophorectomy (BSO), a female-specific risk factor for dementia, is associated with reduced medial temporal lobe structure and function. Younger middle-aged women with the BRCA1/2 mutation and a BSO prior to spontaneous menopause (SM) were recruited. We determined the performance of women with BSO not taking estradiol-based hormone therapy (n = 18) on a task measuring object and scene recognition and quantified medial temporal lobe subregion volumes using manually segmented high-resolution T2-weighted MRI scans...
September 2022: Neurobiology of Aging