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https://www.readbyqxmd.com/read/29785232/effects-of-fasudil-on-patients-with-pulmonary-hypertension-associated-with-left-ventricular-heart-failure-with-preserved-ejection-fraction-a-prospective-intervention-study
#1
Xiang Zhang, Xueming Zhang, Saihua Wang, Jun Luo, Zhihong Zhao, Changzhu Zheng, Jieyan Shen
Background: Pulmonary hypertension due to left ventricular heart failure with preserved ejection fraction (PH-HFpEF) is an increasingly medical problem. The aim of the study was to evaluate the clinical efficacy of fasudil on PH-HFpEF elderly patients and to figure out the subtype of PH-HFpEF which may be the therapeutic object of fasudil. Method: 58 PH-HFpEF elderly patients were enrolled. Patients were diagnosed with passive pulmonary hypertension (PPH) or reactive pulmonary hypertension (RPH) by right heart catheterization and all receiving Rho kinase inhibitor fasudil for 2 weeks...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29782283/-heart-failure-with-preserved-left-ventricular-ejection-fraction-epidemiology-patient-%C3%A2-portrait%C3%A2-clinic-and-diagnostics
#2
S V Gavryushina, F T Ageev
The article focuses on current aspects of epidemiology, clinical picture, and diagnostics of patients with chronic heart failure (CHF) associated with preserved left ventricular (LV) systolic function. Heart failure with preserved LV ejection fraction (HFpEF) is shown to be prevalent in a population that accounts for more than a half of all CHF cases. The group at risk for HFpEF consists primarily of older women with arterial hypertension, type 2 diabetes mellitus, obesity, and atrial fibrillation. The article presents algorithms for diagnosis of HFpEF based on classic and tissue Doppler echocardiography and measurement of natriuretic peptides...
2018: Kardiologiia
https://www.readbyqxmd.com/read/29782281/-effect-of-chronic-kidney-disease-on-the-formation-of-diastolic-heart-dysfunction-in-heart-failure-patients-with-preserved-ejection-fraction
#3
O B Kuzmin, V V Zezha, V V Belyanin, N V Buchneva
Chronic kidney disease is observed in most patients with CHF with preserved ejection fraction (HFpEF) and presents a major risk factor facilitating development and progression of LV diastolic dysfunction. The review focused on the effect of chronic kidney disease on intracellular signaling pathways affecting stiffness and diastolic relaxation of cardiomyocytes in response to inflammation and endothelial dysfunction of coronary capillaries, excessive sympathetic activation, and dysregulation of natriuretic peptides, which directly participate in the development of CHF...
2018: Kardiologiia
https://www.readbyqxmd.com/read/29782277/-association-of-polymorphism-4a-4b-and-4b-4b-in-endothelial-nitric-oxide-synthase-gene-and-markers-of-endothelial-dysfunction-in-patients-with-chronic-heart-failure
#4
E A Polunina, L P Voronina, I V Sevostyanova, O S Polunina, D S Tarasochkina
AIM: To examine the association of polymorphism 4a/4b and 4b/4b in endothelial nitric oxide synthase gene (eNOS) with levels of natriuretic peptide type-C, endothelin-1 and vasoregulative endothelial function in patients with chronic heart failure (CHF) depending on the ejection fraction of the left ventricle. MATERIALS AND METHODS: The study has included 280 patients with CHF of ischemic etiology and 60 somatically healthy individuals. A comprehensive assessment of the markers of the vascular endothelium function was carried out for all patients (endothelial function coefficient, natriuretic peptide type-C, endothelin-1) in association of polymorphism 4a/4b and 4b/4b gene of eNOS...
2018: Kardiologiia
https://www.readbyqxmd.com/read/29782275/-specific-features-of-pharmacotherapy-of-patients-with-chronic-heart-failure-and-preserved-left-ventricular-ejection-fraction
#5
V N Larina, M V Leonova, I I Chukaeva, D G Karpenko
The review is devoted to pharmacotherapy of chronic heart failure (CHF) with preserved left ventricular ejection fraction. In this review we discuss data of meta-analyzes of randomized clinical trials and observational studies, as well as the indications for use of inhibitors of the renin-angiotensin-aldosterone system, β-blockers, and antagonists of mineralocorticoid receptors in these patients in current clinical guidelines. New approaches to therapy of CHF from the perspective of influence on myocardial fibrosis are considered in this review...
March 2018: Kardiologiia
https://www.readbyqxmd.com/read/29782258/-contractile-function-of-isolated-hearts-with-preserved-and-reduced-ejection-fraction-in-vivo
#6
V L Lakomkin, A A Abramov, V V Gramovich, O N Vyborov, I M Studneva, O I Pisarenko, V I Kapelko
The aim of the study was comparison of contractile function of isolated hearts of rats with doxorubicin-induced myocardial injury which were tentatively divided according to the level of ejection fraction determined by echocardiography in vivo. After 4 weeks of doxorubicin administration (2 mg/kg subcutaneously once a week) about half of animals had normal (86±1 %) and the other half reduced (61±4 %) ejection fraction. The first group was defined as diastolic heart failure (DHF) and the other as systolic (SHF)...
April 2018: Kardiologiia
https://www.readbyqxmd.com/read/29782250/-effect-of-right-ventricular-myocardial-contractility-on-the-response-to-cardiac-resynchronization-therapy
#7
D I Lebedev, S V Popov, A I Mishkina, M V Lebedeva
AIM: To determine the effect of right ventricular myocardial contractility on the response to cardiac resynchronization therapy (CRT). MATERIALS AND METHODS: The study included 80 patients (49 men, mean age 54±10.5) diagnosed with dilated cardiomyopathy, complete left bundle branch block, and the QRS complex width 146 to 240 ms (183±32 ms). Heart failure was NYHA FC III, ejection fraction (EF) - 30.1±3.8 %, 6‑min walk test - 290.5±64.3 m, and end-diastolic volume (EDV) - 220...
2018: Kardiologiia
https://www.readbyqxmd.com/read/29781109/rate-pressure-product-and-the-components-of-heart-rate-and-systolic-blood-pressure-in-hospitalized-heart-failure-patients-with-preserved-ejection-fraction-insights-from-ascend-hf
#8
Amanda K Verma, Jie-Lena Sun, Adrian Hernandez, John R Teerlink, Phillip J Schulte, Justin Ezekowitz, Adriaan Voors, Randall Starling, Paul Armstrong, Christopher M O'Conner, Robert J Mentz
BACKGROUND: Heart rate (HR) and systolic blood pressure (SBP) are prognostic markers in heart failure with reduced ejection fraction (HFrEF). Their combination in rate-pressure product (RPP) as well as their role in heart failure with preserved ejection fraction (HFpEF) remains unclear. METHODS: We performed an analysis of ASCEND-HF (clinicaltrials.gov; NCT00476852), which studied 7141 patients with acute HF. HFpEF was defined as left ventricular ejection fraction (LVEF) ≥40%...
May 20, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29779951/is-the-paradigm-hf-cohort-representative-of-the-real-world-heart-failure-patient-population
#9
Gustavo Rodrigues, António Tralhão, Carlos Aguiar, Pedro Freitas, António Ventosa, Miguel Mendes
INTRODUCTION: A new drug with prognostic impact on heart failure, sacubitril/valsartan, has been introduced in current guidelines. However, randomized trial results can be compromised by lack of representativeness. We aimed to assess the representativeness of the PARADIGM-HF trial in a real-world population of patients with heart failure. METHODS: We reviewed the records of 196 outpatients followed in a heart failure clinic between January 2013 and December 2014...
May 17, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29778859/diagnosis-of-nonischemic-stage-b-heart-failure-in-type-2-diabetes-mellitus-optimal-parameters-for-prediction-of-heart-failure
#10
Ying Wang, Hong Yang, Quan Huynh, Mark Nolan, Kazuaki Negishi, Thomas H Marwick
OBJECTIVES: This study sought to identify whether impaired global longitudinal strain (GLS), diastolic dysfunction (DD), or left atrial enlargement (LAE) should be added to stage B heart failure (SBHF) criteria in asymptomatic patients with type 2 diabetes mellitus. BACKGROUND: SBHF is a precursor to clinical heart failure (HF), and its recognition justifies initiation of cardioprotective therapy. However, original definitions of SBHF were based on LV hypertrophy and impaired ejection fraction...
May 11, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29776421/evidence-for-a-hyper-reductive-redox-in-a-sub-set-of-heart-failure-patients
#11
Thiagarajan Sairam, Amit N Patel, Meenu Subrahmanian, Rajendiran Gopalan, Steven M Pogwizd, Sudha Ramalingam, Ramalingam Sankaran, Namakkal Soorapan Rajasekaran
BACKGROUND: Oxidative stress has been linked to heart failure (HF) in humans. Antioxidant-based treatments are often ineffective. Therefore, we hypothesize that some of the HF patients might have a reductive stress (RS) condition. Investigating RS-related mechanisms will aid in personalized optimization of redox homeostasis for better outcomes among HF patients. METHODS: Blood samples were collected from HF patients (n = 54) and healthy controls (n = 42) and serum was immediately preserved in - 80 °C for redox analysis...
May 18, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29773163/epicardial-adipose-tissue-may-mediate-deleterious-effects-of-obesity-and-inflammation-on-the-myocardium
#12
REVIEW
Milton Packer
Epicardial adipose tissue has unique properties that distinguish it from other depots of visceral fat. Rather than having distinct boundaries, the epicardium shares an unobstructed microcirculation with the underlying myocardium, and in healthy conditions, produces cytokines that nourish the heart. However, in chronic inflammatory disorders (especially those leading to heart failure with preserved ejection fraction), the epicardium becomes a site of deranged adipogenesis, leading to the secretion of proinflammatory adipokines that can cause atrial and ventricular fibrosis...
May 22, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29769316/the-serine-threonine-protein-kinase-endoribonuclease-ire1%C3%AE-protects-the-heart-against-pressure-overload-induced-heart-failure
#13
DeAnna Steiger, Tomohiro Yokota, Jin Li, Shuxun Ren, Susumu Minamisawa, Yibin Wang
Heart failure is associated with induction of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR). The serine/threonine protein kinase/endoribonuclease IRE1α is a key protein in ER stress signal transduction. IRE1α activity can induce both protective UPR and apoptotic downstream signaling events, but the specific role for IRE1α activity in the heart is unknown. A major aim of this study was to characterize the specific contribution of IRE1α in cardiac physiology and pathogenesis. We used both cultured myocytes and a transgenic mouse line with inducible and cardiomyocyte-specific IRE1α overexpression as experimental models to achieve targeted IRE1α activation...
May 16, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29767239/time%C3%A2-dependent-and-independent-effects-of-thyroid-hormone-administration-following-myocardial-infarction-in-rats
#14
Ioanna Iliopoulou, Iordanis Mourouzis, George I Lambrou, Dimitra Iliopoulou, Dimitrios-Dionysios Koutsouris, Constantinos Pantos
Cardiac function is reduced following myocardial infarction (MI) due to myocardial injury and alterations in the viable non‑ischemic myocardium, a process known as cardiac remodeling. The current treatments available for patients with acute MI (AMI) reduce infarct size, preserve left ventricular (LV) function and improve survival; however, these treatments do not prevent remodeling, which can lead to heart failure. The aim of the present study was to investigate the effects of thyroid hormone (TH) treatment following MI in an in vivo rat model...
May 11, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29762842/the-role-of-commonly-used-clinical-indicators-in-the-diagnosis-of-acute-heart-failure
#15
X-L Wang, J-M Lei, Y Yuan, L Feng, Y Ning, Y-F Liu
OBJECTIVE: Acute heart failure (AHF) is one of the most commonly seen clinical cases, with a high rate of re-hospitalization and mortality. AHF can be divided into two categories based on the systolic function of the left ventricle, which are heart failure with reduced ejection fraction (HFREF) and heart failure with preserved ejection fraction (HFPEF). Pathogenesis and treatment of the two are quite different. In this article we attempted to explore the value of combined use of clinical and laboratory indicators in the differential diagnosis of AHFREF and AHFPEF...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29761090/the-role-of-vascular-calcification-in-heart-failure-and-cognitive-decline
#16
REVIEW
Hao-Min Cheng, Jiun-Jr Wang, Chen-Huan Chen
Vascular calcification is heterogeneous and triggered by multiple mechanisms. It has been implicated in the development of heart failure with preserved ejection fraction (HFpEF) and cognitive function impairment. Understanding the pathophysiology of vascular calcification may help us improve the management of HFpEF, atherosclerosis, accelerated arterial stiffness, hypertension, and cognitive dysfunction. Currently, there are no effective strategies for treating accelerated arterial stiffness. This may indicate that once arterial stiffness or vascular calcification has developed, it may be less likely to stop the ongoing pathophysiology...
March 2018: Pulse (Basel, Switzerland)
https://www.readbyqxmd.com/read/29760016/diabetes-induced-cardiomyocyte-passive-stiffening-is-caused-by-impaired-insulin-dependent-titin-modification-and-can-be-modulated-by-neuregulin-1
#17
Anna-Eliane Hopf, Christian Andresen, Sebastian Kötter, Malgorzata Isic, Kamila Ulrich, Senem Sahin, Sabine Bongardt, Wilhelm Roell, Felicitas Drove, Nina Scheerer, Leni Vandekerckhove, Gilles W De Keulenaer, Nazha Hamdani, Wolfgang A Linke, Martina Krüger
<u>Rationale:</u> Increased titin-dependent cardiomyocyte tension is a hallmark of heart failure with preserved ejection fraction (HFpEF) associated with type-2 diabetes mellitus (T2DM). However, the insulin-related signaling pathways that modify titin-based cardiomyocyte tension, thereby contributing to modulation of diastolic function, are largely unknown. <u>Objective:</u> We aimed to determine how impaired insulin signaling affects titin expression and phosphorylation and thus increases passive cardiomyocyte tension, and whether metformin or neuregulin-1 can correct disturbed titin modifications and increased titin-based stiffness...
May 14, 2018: Circulation Research
https://www.readbyqxmd.com/read/29753564/left-atrium-and-pulmonary-artery-compression-due-to-aortic-aneurysm-causing-heart-failure-symptoms
#18
Antonio José Lagoeiro Jorge, Wolney de Andrade Martins, Victor M Moutinho, Juliano M Rezende, Patricia Y Alves, Humberto Villacorta, Pedro F Silveira, Antonio A Couto
Patients with thoracic aortic aneurysm (TAA) are mostly asymptomatic and TAA is rarely related to heart failure (HF). We report the case of an 80-year-old female patient, with type A TAA without dissection, with right pulmonary artery and left atrium compression, who presented with HF, preserved ejection fraction and acute pulmonary edema.
May 9, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29748074/-altitude-and-the-right-heart
#19
REVIEW
R Naeije
INTRODUCTION: Altitude is associated with a decrease in partial pressure of oxygen. Hypoxia induces pulmonary vasoconstriction with subsequent fixed increase in pulmonary artery pressure, and eventual right heart failure. CURRENT KNOWLEDGE: High altitude exposure is associated with an increase in pulmonary artery pressure that is proportional to initial vasoconstriction. Echocardiographic evaluations on a large number of subjects show that the altitude-induced increase in pulmonary pressure is generally modest and does not exceed the 25mmHg that are diagnostic of pulmonary hypertension...
May 7, 2018: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29746913/the-controversy-continues-what-is-the-role-of-diastolic-function-by-echo-doppler-in-patients-with-heart-failure-and-preserved-ejection-fraction
#20
EDITORIAL
John Gorcsan
No abstract text is available yet for this article.
May 7, 2018: Journal of Cardiac Failure
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