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Carmeli

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https://www.readbyqxmd.com/read/28646794/dexibuprofen-prevents-neurodegeneration-and-cognitive-decline-in-appswe-ps1de9-through-multiple-signaling-pathways
#1
Miren Ettcheto, Elena Sánchez-López, Laura Pons, Oriol Busquets, Jordi Olloquequi, Carlos Beas-Zarate, Merce Pallas, Maria Luisa García, Carme Auladell, Jaume Folch, Antoni Camins
The aim of the present study is to elucidate the neuronal pathways associated to NSAIDs causing a reduction of the risk and progression of Alzheimer's disease. The research was developed administering the active enantiomer of ibuprofen, dexibuprofen (DXI), in order to reduce associated gastric toxicity. DXI was administered from three to six-month-old female APPswe/PS1dE9 mice as a model of familial Alzheimer's disease. DXI treatment reduced the activation of glial cells and the cytokine release involved in the neurodegenerative process, especially TNFα...
June 15, 2017: Redox Biology
https://www.readbyqxmd.com/read/28638770/sequential-uncaging-with-green-light-can-be-achieved-by-fine-tuning-the-structure-of-a-dicyanocoumarin-chromophore
#2
Albert Gandioso, Marta Palau, Alba Nin-Hill, Ivanna Melnyk, Carme Rovira, Santi Nonell, Dolores Velasco, Jaume García-Amorós, Vicente Marchán
We report the synthesis and photochemical properties of a series of dicyanocoumarinylmethyl (DEAdcCM)- and dicyanocoumarinylethyl (DEAdcCE)-based photocages of carboxylic acids and amines with absorption maximum around 500 nm. Photolysis studies with green light have demonstrated that the structure of the coumarin chromophore as well as the nature of the leaving group and the type of bond to be photocleaved (ester or carbamate) have a strong influence on the rate and efficiency of the uncaging process. These experimental observations were also supported by DFT calculations...
June 2017: ChemistryOpen
https://www.readbyqxmd.com/read/28608616/whole-brain-structural-connectivity-in-dyskinetic-cerebral-palsy-and-its-association-with-motor-and-cognitive-function
#3
Júlia Ballester-Plané, Ruben Schmidt, Olga Laporta-Hoyos, Carme Junqué, Élida Vázquez, Ignacio Delgado, Leire Zubiaurre-Elorza, Alfons Macaya, Pilar Póo, Esther Toro, Marcel A de Reus, Martijn P van den Heuvel, Roser Pueyo
Dyskinetic cerebral palsy (CP) has long been associated with basal ganglia and thalamus lesions. Recent evidence further points at white matter (WM) damage. This study aims to identify altered WM pathways in dyskinetic CP from a standardized, connectome-based approach, and to assess structure-function relationship in WM pathways for clinical outcomes. Individual connectome maps of 25 subjects with dyskinetic CP and 24 healthy controls were obtained combining a structural parcellation scheme with whole-brain deterministic tractography...
June 13, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28604696/a-front-face-sni-synthase-engineered-from-a-retaining-double-sn2-hydrolase
#4
Javier Iglesias-Fernández, Susan M Hancock, Seung Seo Lee, Maola Khan, Jo Kirkpatrick, Neil J Oldham, Katherine McAuley, Anthony Fordham-Skelton, Carme Rovira, Benjamin G Davis
SNi-like mechanisms, which involve front-face leaving group departure and nucleophile approach, have been observed experimentally and computationally in chemical and enzymatic substitution at α-glycosyl electrophiles. Since SNi-like, SN1 and SN2 substitution pathways can be energetically comparable, engineered switching could be feasible. Here, engineering of Sulfolobus solfataricus β-glycosidase, which originally catalyzed double SN2 substitution, changed its mode to SNi-like. Destruction of the first SN2 nucleophile through E387Y mutation created a β-stereoselective catalyst for glycoside synthesis from activated substrates, despite lacking a nucleophile...
June 12, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28600975/relationship-and-significance-of-gait-deviations-associated-with-limb-length-discrepancy-a-systematic-review
#5
REVIEW
Sam Khamis, Eli Carmeli
Controversy still exists as to the clinical significance of leg length discrepancy (LLD) in spite of the fact that further evidence has been emerging regarding the relationship between several clinical conditions and LLD. The objectives of our study were to review the available research with regard to LLD as a cause of clinically significant gait deviations, to determine if there is a relationship between the magnitude of LLD and the presence of gait deviations and to identify the most common gait deviations associated with LLD...
May 31, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28599914/long-term-benefits-of-education-by-emergency-care-nurses-at-discharge-of-patients-with-atrial-fibrillation
#6
Carolina Fuenzalida, Gritzel Hernández, Inés Ferro, Carme Siches, Àngels Ambrós, Blanca Coll-Vinent
INTRODUCTION AND OBJECTIVE: Health education improves the prognosis of many diseases. A previous study in patients with atrial fibrillation (AF) showed that an educational intervention by nurses at discharge from the emergency room (ER) decreased AF-related complications at 3-month follow-up. Our objective was to determine whether this intervention had a long-term effect. PATIENTS AND METHODS: A prospective study assessed the outcomes of an intervention carried out upon discharge from the ER...
June 6, 2017: International Emergency Nursing
https://www.readbyqxmd.com/read/28593439/clinical-and-histopathological-amelioration-of-experimental-autoimmune-encephalomyelitis-by-aav-vectors-expressing-a-soluble-interleukin-23-receptor
#7
Marta Miralles, Herena Eixarch, Marcos Tejero, Carme Costa, Keiji Hirota, A Raul Castaño, Meritxell Puig, Gitta Stockinger, Xavier Montalban, Assumpció Bosch, Carmen Espejo, Miguel Chillon
The role of the T helper (Th)17 pathway has been clearly demonstrated in the onset and progression of autoimmune diseases, where interleukin (IL)-23 is a key molecule in maintaining the response mediated by Th17 cells. As a consequence, recent strategies based on blocking the interaction between IL-23 and its receptor (IL-23R), for example the anti-p19 antibody tildrakizumab, have been developed to regulate the Th17 pathway from the initial stages of the disease. Here, a soluble (s)IL-23R cDNA was cloned in expression plasmids and viral vectors...
June 7, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/28593298/increased-cardiovascular-risk-associated-with-e-cigarette-use
#8
Fabian Sanchis-Gomar, Giuseppe Lippi, Carme Perez-Quilis
No abstract text is available yet for this article.
June 7, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28588404/probing-quantum-state-space-does-one-have-to-learn-everything-to-learn-something
#9
Claudio Carmeli, Teiko Heinosaari, Jussi Schultz, Alessandro Toigo
Determining the state of a quantum system is a consuming procedure. For this reason, whenever one is interested only in some particular property of a state, it would be desirable to design a measurement set-up that reveals this property with as little effort as possible. Here, we investigate whether, in order to successfully complete a given task of this kind, one needs an informationally complete measurement, or if something less demanding would suffice. The first alternative means that in order to complete the task, one needs a measurement which fully determines the state...
May 2017: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28586720/study-of-galfenol-direct-cytotoxicity-and-remote-microactuation-in-cells
#10
Carolina Vargas-Estevez, Andreu Blanquer, Prabesh Dulal, Rafael Pérez Del Real, Marta Duch, Elena Ibáñez, Leonardo Barrios, Gonzalo Murillo, Núria Torras, Carme Nogués, Bethanie J H Stadler, José A Plaza, Jaume Esteve
Remote microactuators are of great interest in biology and medicine as minimally-invasive tools for cellular stimulation. Remote actuation can be achieved by active magnetostrictive transducers which are capable of changing shape in response to external magnetic fields thereby creating controlled displacements. Among the magnetostrictive materials, Galfenol, the multifaceted iron-based smart material, offers high magnetostriction with robust mechanical properties. In order to explore these capabilities for biomedical applications, it is necessary to study the feasibility of material miniaturization in standard fabrication processes as well as evaluate the biocompatibility...
September 2017: Biomaterials
https://www.readbyqxmd.com/read/28574835/prognostic-micrornas-in-upper-tract-urothelial-carcinoma-multicenter-and-international-validation-study
#11
Laura Izquierdo, Ruth Montalbo, Mercedes Ingelmo-Torres, Carme Mallofré, Miguel Ramírez-Backhaus, Jose Rubio, Antoine G Van der Heijden, Ewout Schaafsma, Antonio Lopez-Beltran, A Blanca, Nathan Lawrentschuk, Antonio Alcaraz, Lourdes Mengual
OBJECTIVE: To validate previously discovered miRNAs (miR-31-5p and miR-149-5p) as prognostic factors for UTUC in an independent cohort of UTUC patients. PATIENTS AND METHODS: Multicenter, international and retrospective study of formalin-fixed paraffin-embedded tissue samples from 103 UTUC patients (45 progressing and 58 non-progressing) who underwent radical nephroureterectomy. Total RNA was isolated and reverse transcribed. The expression of target miRNAs (miR-31-5p and miR-149-5p) and the endogenous control miR-218-5p was evaluated in all samples by reverse transcription quantitative PCR...
May 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28574260/mollecarbamates-molleureas-and-molledihydroisoquinolone-o-carboxyphenethylamide-metabolites-of-the-ascidian-didemnum-molle-collected-in-madagascar
#12
Michal Issac, Maurice Aknin, Anne Gauvin-Bialecki, Christopher D Pond, Louis R Barrows, Yoel Kashman, Shmuel Carmeli
The extract of a sample of the tunicate Didemnum molle (MAY13-117) collected in Mayotte afforded eight new metabolites, mollecarbamates A-D (1-4) and molleureas B-E (5-8), along with the two known natural products, N,N'-diphenylethyl urea (10) and molleurea A (11). Another sample of D. molle (MAD11-BA065) collected in Baie des Assassins, Madagascar, afforded molledihydroisoquinolone (9). Mollecarbamates 1-4 are a family of compounds that possess repeating o-carboxyphenethylamide units and a carbamate moiety, while the molleureas 5-8 contain tetra- and penta-repeating carboxyphenethylamide units and a urea bridge in different positions...
June 2, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28573556/the-influence-of-bone-loss-on-the-three-adult-age-markers-of-the-innominate
#13
Carme Rissech, Jo Appleby, Alessandra Cosso, Francisco Reina, Anna Carrera, Richard Thomas
To evaluate the influence of bone loss on the three adult age markers of the innominate, 30 males and 30 females aged between 16 and 80 years coming from the British Coventry collection were analyzed. The pubic symphysis, auricular surface, and acetabulum age variables were evaluated following the descriptions of Schmitt, Buckberry-Chamberlain, and Rissech, respectively. The second metacarpal cortical index was used to evaluate bone loss. Possible sexual differences in metrical variables were explored by a Student t-test taking into account the entire sample...
June 1, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28572947/development-of-a-fermented-quinoa-based-beverage
#14
Fanny Emma Ludena Urquizo, Silvia Melissa García Torres, Tiina Tolonen, Mari Jaakkola, Maria Grazzia Pena-Niebuhr, Atte von Wright, Ritva Repo-Carrasco-Valencia, Hannu Korhonen, Carme Plumed-Ferrer
Quinoa is a crop that originated from the Andes. It has high nutritional value, outstanding agro-ecological adaptability, and low water requirements. Quinoa is an excellent crop alternative to help overcome food shortages, and it can also have a role in the prevention of developed world lifestyle diseases, such as type-2 diabetes, cardiovascular diseases, osteoporosis, inflammatory and autoimmune diseases, etc. In order to expand the traditional uses of quinoa and to provide new, healthier and more nutritious food products, a fermented quinoa-based beverage was developed...
May 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28558856/incidence-and-risk-factors-for-community-and-hospital-acquisition-of-clostridium-difficile-infection-in-the-tel-aviv-sourasky-medical-center
#15
Wasef Na'amnih, Amos Adler, Tamar Miller-Roll, Dani Cohen, Yehuda Carmeli
OBJECTIVES To estimate the incidence and identified risk factors for community-acquired (CA) and hospital-acquired (HA) Clostridium difficile infection (CDI) METHODS We conducted 2 parallel case-control studies at Tel Aviv Sourasky Medical Center from January 1, 2011, to December 31, 2014. We identified persons with CDI, determined whether infection was community or hospital acquired, and calculated incidence rates from 2007 to 2014. We collected demographic, clinical, and epidemiological information for CDI cases and hospitalized control cases and estimated the odds ratio with 95% confidence interval using conditional logistic regression...
May 31, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28557991/socioeconomic-indicators-in-epidemiologic-research-a-practical-example-from-the-lifepath-study
#16
Angelo d'Errico, Fulvio Ricceri, Silvia Stringhini, Cristian Carmeli, Mika Kivimaki, Mel Bartley, Cathal McCrory, Murielle Bochud, Peter Vollenweider, Rosario Tumino, Marcel Goldberg, Marie Zins, Henrique Barros, Graham Giles, Gianluca Severi, Giuseppe Costa, Paolo Vineis
BACKGROUND: Several social indicators have been used in epidemiological research to describe socioeconomic position (SEP) of people in societies. Among SEP indicators, those more frequently used are education, occupational class and income. Differences in the incidence of several health outcomes have been reported consistently, independently from the indicator employed. Main objectives of the study were to present the socioeconomic classifications of the social indicators which will be employed throughout the LIFEPATH project and to compare social gradients in all-cause mortality observed in the participating adult cohorts using the different SEP indicators...
2017: PloS One
https://www.readbyqxmd.com/read/28551938/-horizontal-canal-benign-paroxysmal-positional-vertigo-hc-bppv-clinical-diagnostic-procedures
#17
REVIEW
Oz Zur, Ophir Ilan, Hadas Ben-Rubi Shimron, Eli Carmeli
Horizontal canal benign paroxysmal positional vertigo (HCBPPV) is one form of benign paroxysmal positional vertigo. HC-BPPV is characterized by intermittent recurrent episodes of vertigo following a change in head position relative to gravity. HC-BPPV prevalence ranges from 5%-33% of all dizziness cases seen in otolaryngology, neurology and family physician clinics. Various factors, such as ear and head injury, can cause HC-BPPV. Cardiovascular disease and iatrogenic reasons are also implicated. Despite the prevalence of the disease, there are various forms of diagnostic procedures, some of which are unfamiliar to the therapist and some are controversial...
March 2017: Harefuah
https://www.readbyqxmd.com/read/28536736/is-the-association-between-hip-fractures-and-seasonality-modified-by-influenza-vaccination-an-ecological-study
#18
M Fraenkel, M Yitshak-Sade, L Beacher, M Carmeli, M Mandelboim, E Siris, V Novack
Osteoporotic hip fractures in 4344 patients were more common during winter. Lower temperatures were associated with higher rates of fracture only in those not vaccinated for influenza. Influenza outbreaks increased the risk of hip fractures. Further studies are needed to assess whether influenza vaccination can prevent hip fractures. INTRODUCTION: Winter seasonality of osteoporotic hip fracture incidence has been demonstrated, yet the explanation for the association is lacking. We hypothesize that the seasonality of osteoporotic hip fracture can be explained by an association between hip fractures and seasonal influenza outbreaks...
May 23, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28522962/alterations-in-cd200-cd200r1-system-during-eae-already-manifest-at-presymptomatic-stages
#19
Tony Valente, Joan Serratosa, Unai Perpiñá, Josep Saura, Carme Solà
In the brain of patients with multiple sclerosis, activated microglia/macrophages appear in active lesions and in normal appearing white matter. However, whether they play a beneficial or a detrimental role in the development of the pathology remains a controversial issue. The production of pro-inflammatory molecules by chronically activated microglial cells is suggested to contribute to the progression of neurodegenerative processes in neurological disease. In the healthy brain, neurons control glial activation through several inhibitory mechanisms, such as the CD200-CD200R1 interaction...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28522171/brain-correlates-of-progressive-olfactory-loss-in-parkinson-s-disease
#20
Anna Campabadal, Carme Uribe, Barbara Segura, Hugo C Baggio, Alexandra Abos, Anna Isabel Garcia-Diaz, Maria Jose Marti, Francesc Valldeoriola, Yaroslau Compta, Nuria Bargallo, Carme Junque
BACKGROUND: Olfactory dysfunction is present in a large proportion of patients with Parkinson's disease (PD) upon diagnosis. However, its progression over time has been poorly investigated. The few available longitudinal studies lack control groups or MRI data. OBJECTIVE: To investigate the olfactory changes and their structural correlates in non-demented PD over a four-year follow-up. METHODS: We assessed olfactory function in a sample of 25 PD patients and 24 normal controls of similar age using the University of Pennsylvania Smell Identification test (UPSIT)...
May 10, 2017: Parkinsonism & related Disorders
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