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https://www.readbyqxmd.com/read/29020250/empiric-therapy-with-carbapenem-sparing-regimens-for-bloodstream-infections-due-to-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-results-from-the-increment-cohort
#1
Zaira Raquel Palacios-Baena, Belén Gutiérrez-Gutiérrez, Esther Calbo, Benito Almirante, Pierluigi Viale, Antonio Oliver, Vicente Pintado, Oriol Gasch, Luis Martínez-Martínez, Johann Pitout, Murat Akova, Carmen Peña, José Molina Gil-Bermejo, Alicia Hernández, Mario Venditti, Nuria Prim, German Bou, Evelina Tacconelli, Mario Tumbarello, Axel Hamprecht, Helen Giamarellou, Manel Almela, Federico Pérez, Mitchell J Schwaber, Joaquín Bermejo, Warren Lowman, Po-Ren Hsueh, José Ramón Paño-Pardo, Julián Torre-Cisneros, Maria Souli, Robert A Bonomo, Yehuda Carmeli, David L Paterson, Álvaro Pascual, Jesús Rodríguez-Baño
Background: There is little information about the efficacy of active alternative drugs to carbapenems except β-lactam/β-lactamase inhibitors for the treatment of bloodstream infections (BSIs) due to extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E). The objective of this study was to assess the outcomes of patients with BSI due to ESBL-E who received empiric therapy with such drugs (other active drugs [OADs]) or carbapenems. Methods: A multinational retrospective cohort study of patients with BSI due to ESBL-E who received empiric treatment with OADs or carbapenems was performed...
August 19, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29020228/the-impact-of-a-carbapenem-resistant-enterobacteriaceae-outbreak-on-facilitating-development-of-a-national-infrastructure-for-infection-control-in-israel
#2
Mitchell J Schwaber, Yehuda Carmeli
In 2006 the Israeli healthcare system faced an unprecedented outbreak of carbapenem-resistant Enterobacteriaceae, primarily involving KPC-producing Klebsiella pneumoniae clonal complex CC258. This public health crisis exposed major gaps in infection control. In response, Israel established a national infection control infrastructure. The steps taken to build this infrastructure and benefits realized from its creation are described here.
July 19, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29018011/balance-versus-hearing-after-cochlear-implant-in-an-adult
#3
Oz Zur, Hadas Ben-Rubi Shimron, Gerry Leisman, Eli Carmeli
The effect of vestibular rehabilitation (VR) on anxiety, dizziness and poor balance that developed after cochlear implant (CI) surgery is described. A 54-year-old woman, with profound hearing loss since the age of 2 years, underwent right CI surgery 2 years previously. On implant activation, the patient immediately felt dizziness and imbalance, which affected the ability to perform activities of daily living and increased anxiety to where the patient considered the CI removal. Prior to VR the patient was evaluated with the Dizziness Handicap Inventory and the Visual Vertigo Dizziness Questionnaire and clinically with the Zur Balance Scale and Video Head Impulse Test...
October 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28993095/comparison-of-the-brainstem-auditory-evoked-responses-during-sevoflurane-or-alfaxalone-anaesthesia-in-adult-cats
#4
Carlos Ros, Carme Soler, Alejandra García de Carellán Mateo
OBJECTIVE: To compare the effects of general anaesthesia using sevoflurane or alfaxalone on the brainstem auditory evoked response (BAER) test in adult healthy cats. STUDY DESIGN: Prospective, clinical, 'blinded', crossover study. ANIMALS: Ten feral adult healthy cats. METHODS: Premedication consisted of dexmedetomidine (0.01 mg kg(-1)) intramuscularly (IM). The first general anaesthesia was induced and maintained with sevoflurane (treatment S) for physical examination, BAER test, complete blood tests, thoracic radiographs and abdominal ultrasound...
March 2, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28987858/-effectiveness-of-an-educational-program-for-respiratory-rehabilitation-of-chronic-obstructive-pulmonary-disease-patients-in-primary-care-in-improving-the-quality-of-life-symptoms-and-clinical-risk
#5
Cristina Blánquez Moreno, Cristina Colungo Francia, M Carme Alvira Balada, Belchin Kostov, Luis González-de Paz, Antoni Sisó-Almirall
AIM: To determine the impact of an educational program to improve the management of chronic obstructive pulmonary disease (COPD) that contributes to an increase of the quality of life, exercise capacity, level of dyspnoea, and clinical risk. DESIGN: Intervention study without controls. LOCATION: Primary Healthcare Centre. PARTICIPANTS: 193 patients with COPD were invited, 73 accepted and 55 participated in the educational program...
October 4, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28981629/usefulness-of-transcriptional-blood-biomarkers-as-a-non-invasive-surrogate-marker-of-mucosal-healing-and-endoscopic-response-in-ulcerative-colitis
#6
Núria Planell, M Carme Masamunt, Raquel Franco Leal, Lorena Rodríguez, Miriam Esteller, Juan J Lozano, Anna Ramírez, Maria de Lourdes Setsuko Ayrizono, Claudio Saddy Rodrigues Coy, Ignacio Alfaro, Ingrid Ordás, Sudha Visvanathan, Elena Ricart, Jordi Guardiola, Julián Panés, Azucena Salas
Background and Aims: Ulcerative colitis [UC] is a chronic inflammatory disease of the colon. Colonoscopy remains the gold standard for evaluating disease activity, as clinical symptoms are not sufficiently accurate. The aim of this study is to identify new accurate non-invasive biomarkers based on whole-blood transcriptomics that can predict mucosal lesions and response to treatment in UC patients. Methods: Whole-blood samples were collected for a total of 152 UC patients at endoscopy...
July 10, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28980273/specialized-pain-clinics-in-primary-care-common-diagnoses-referral-patterns-and-clinical-outcomes-novel-pain-management-model
#7
Yacov Fogelman, Eli Carmeli, Amir Minerbi, Baruch Harash, Simon Vulfsons
An estimated 19% of the adult population in western countries lives with chronic pain. Pain management lies mainly within the primary care and community setting. We evaluated the outcome of a new model of secondary care clinics, conducted by primary care physicians with specialized training in pain medicine. Data on referral patterns, prevalence of pain diagnosis, and medication consumption were recorded at five secondary pain management clinics in the community setting. In total, 997 patients with pain attended 2,652 visits (average 2...
October 5, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28979691/fascin-1-is-released-from-proximal-tubular-cells-in-response-to-calcineurin-inhibitors-cnis-and-correlates-with-isometric-vacuolization-in-kidney-transplanted-patients
#8
Conxita Jacobs-Cachá, Irina B Torres, Joan López-Hellín, Carme Cantarell, María A Azancot, Antonio Román, Francesc Moreso, Daniel Serón, Anna Meseguer, Eduard Sarró
Immunosuppression based on calcineurin inhibitors (CNIs) has greatly improved organ transplantation, although subsequent nephrotoxicity significantly hinders treatment success. There are no currently available specific soluble biomarkers for CNI-induced nephrotoxicity and diagnosis relies on renal biopsy, which is costly, invasive and may cause complications. Accordingly, identification of non-invasive biomarkers distinguishing CNI-induced kidney tubular damage from that of other etiologies would greatly improve diagnosis and enable more precise dosage adjustment...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28978310/socioeconomic-inequalities-in-suicide-mortality-before-and-after-the-economic-recession-in-spain
#9
Carme Borrell, Marc Marí-Dell'Olmo, Mercè Gotsens, Montse Calvo, Maica Rodríguez-Sanz, Xavier Bartoll, Santiago Esnaola
BACKGROUND: An increase in suicide mortality is often observed in economic recessions. The objective of this study was to analyse trends in socioeconomic inequalities in suicide mortality before and during the economic recession in two geographical settings in Spain. METHODS: This study analyses inequalities in mortality according to educational level during 3 different time periods based on individual data from the Basque Country and Barcelona city. We analysed suicide mortality data for all residents over 25 years of age from 2001 to 2012...
October 4, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28973828/ridge-width-correlations-between-inked-prints-and-powdered-latent-fingerprints
#10
Josep De Alcaraz-Fossoul, Carme Barrot-Feixat, Sara C Zapico, Michelle Mancenido, Jennifer Broatch, Katherine A Roberts, Clara Carreras-Marin, Jack Tasker
A methodology to estimate the time of latent fingerprint deposition would be of great value to law enforcement and courts. It has been observed that ridge topography changes as latent prints age, including the widths of ridges that could be measured as a function of time. Crime suspects are commonly identified using fingerprint databases that contain reference inked tenprints (flat and rolled impressions). These can be of interest in aging studies as they provide baseline information relating to the original (nonaged) ridges' widths...
October 3, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28971901/molecular-and-clinical-profile-of-von-willebrand-disease-in-spain-pcm-evw-es-comprehensive-genetic-analysis-by-next-generation-sequencing-of-480-patients
#11
Nina Borràs, Javier Batlle, Almudena Pérez-Rodríguez, María Fernanda López-Fernández, Ángela Rodríguez-Trillo, Esther Lourés, Ana Rosa Cid, Santiago Bonanad, Noelia Cabrera, Andrés Moret, Rafael Parra, María Eva Mingot-Castellano, Ignacia Balda, Carme Altisent, Rocío Pérez-Montes, Rosa María Fisac, Gemma Iruín, Sonia Herrero, Inmaculada Soto, Beatriz de Rueda, Victor Jimimenez-Yuste, Nieves Alonso, Dolores Vilariño, Olga Arija, Rosa Campos, María José Paloma, Nuria Bermejo, Rubén Berrueco, José Mateo, Karmele Arribalzaga, Pascual Marco, Ángeles Palomo, Lizheidy Sarmiento, Belén Iñigo, María Del Mar Nieto, Rosa Vidal, María Paz Martínez, Reyes Aguinaco, Jesús María César, María Ferreiro, Javier García-Frade, Ana María Rodríguez-Huerta, Jorge Cuesta, Ramón Rodríguez-González, Faustino García-Candel, Rosa Cornudella, Carlos Aguilar, Francisco Vidal, Irene Corrales
Molecular diagnosis of patients with von Willebrand disease is pending in most populations due to the complexity and high cost of conventional molecular analyses. The need for molecular and clinical characterization of von Willebrand disease in Spain prompted the creation of a multicenter project (PCM-EVW-ES) that resulted in the largest prospective cohort study of patients with all types of von Willebrand disease. Molecular analysis of relevant regions of the VWF, including intronic and promoter regions, was achieved in the 556 individuals recruited by development of a simple, innovative, relatively low-cost protocol based on microfluidic technology and next-generation sequencing...
September 29, 2017: Haematologica
https://www.readbyqxmd.com/read/28969847/interatrial-block-frailty-and-prognosis-in-elderly-patients-with-myocardial-infarction
#12
Eva Bernal, Antoni Bayés-Genís, Albert Ariza-Solé, Francesc Formiga, Maria T Vidán, Luis Alberto Escobar-Robledo, Jaime Aboal, Lídia Alcoberro, Carme Guerrero, Iván Ariza-Segovia, Ana Hernandez de Benito, Pau Vilardell, José Carlos Sánchez-Salado, Victoria Lorente, Antoni Bayés de Luna, Manuel Martinez-Sellés
No abstract text is available yet for this article.
September 1, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28969505/the-role-of-contextual-socioeconomic-circumstances-and-neighborhood-poverty-segregation-on-mortality-in-4-european-cities
#13
Chiara Marinacci, Moreno Demaria, Giulia Melis, Carme Borrell, Diana Corman, Marc Marí Dell'Olmo, Maica Rodriguez, Giuseppe Costa
Several studies have recognized the health disadvantage of residents in socioeconomically deprived neighborhoods, independent of the influence of individual socioeconomic conditions. The effect of neighborhood socioeconomic deprivation on general mortality has appeared heterogeneous among the cities analyzed: the underlying mechanisms have been less empirically explored, and explanations for this heterogeneous health effect remain unclear. The present study aimed to: (1) analyze the distribution of socioeconomically disadvantaged persons in neighborhoods of 4 European cities-Turin, Barcelona, Stockholm and Helsinki-trying to measure segregation of residents according to their socioeconomic conditions...
January 1, 2017: International Journal of Health Services: Planning, Administration, Evaluation
https://www.readbyqxmd.com/read/28967453/-health-literacy-more-than-information
#14
Dolors Juvinyà-Canal, Carme Bertran-Noguer, Rosa Suñer-Soler
No abstract text is available yet for this article.
September 26, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28948921/combination-therapy-for-bloodstream-infections-with-carbapenemase-producing-enterobacteriaceae-authors-reply
#15
Belén Gutiérrez-Gutiérrez, Robert A Bonomo, Yehuda Carmeli, David L Paterson, Alvaro Pascual, Jesús Rodríguez-Baño
No abstract text is available yet for this article.
October 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28903797/prevalence-of-anti-hepatitis-b-surface-antibodies-among-children-and-adolescents-vaccinated-in-infancy-and-effect-of-booster-dose-administered-within-a-pilot-study
#16
R Bassal, M P Markovich, M Weil, E Shinar, Y Carmeli, M Dan, D Sofer, E Mendelson, D Cohen, T Shohat
We determined the prevalence of anti-hepatitis B surface antibodies (anti-HBs) among children and adolescents vaccinated for hepatitis B virus in infancy as part of the routine vaccination programme. A representative serum sample of the Israeli population age 0-19 was tested. In a separate pilot study, a booster dose of hepatitis B vaccine was administered to 31 candidates for national service, who were fully vaccinated in infancy and tested negative for hepatitis B surface antibodies at age 17-19 years and anti-HBs antibodies were assessed 8 weeks later...
September 14, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28893585/thermo-responsive-magnetic-fe3o4-p-meo2max-oegma100-x-nps-and-their-applications-as-drug-delivery-systems
#17
Enaam Jamal Al Dine, Zied Ferjaoui, Jaafar Ghanbaja, Thibault Roques-Carmes, Abdelaziz Meftah, Tayssir Hamieh, Joumana Toufaily, Raphaël Schneider, Sophie Marchal, Eric Gaffet, Halima Alem
The unique physical properties of the superparamagnetic nanoparticles (SPIONs) have made them candidates of choice in nanomedicine especially for diagnostic imaging, therapeutic applications and drug delivery based systems. In this study, superparamagnetic Fe3O4 NPs were synthesized and functionalized with a biocompatible thermoresponsive copolymer to obtain temperature responsive core/shell NPs. The ultimate goal of this work is to build a drug delivery system able to release anticancer drugs in the physiological temperatures range...
November 5, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28884377/idh-mutation-status-trumps-the-pignatti-risk-score-as-a-prognostic-marker-in-low-grade-gliomas
#18
Olatz Etxaniz, Cristina Carrato, Itziar de Aguirre, Cristina Queralt, Ana Muñoz, José L Ramirez, Rafael Rosell, Salvador Villà, Rocio Diaz, Ana Estival, Pilar Teixidor, Alberto Indacochea, Sara Ahjal, Laia Vilà, Carme Balañá
Management of low-grade gliomas (LGG) is based on clinical and radiologic features, including the Pignatti prognostic scoring system, which classifies patients as low- or high-risk. To determine whether molecular data can offer advantages over these features, we have examined the prognostic impact of several molecular alterations in LGG. In a cohort of 58 patients with LGG, we have retrospectively analyzed clinical and molecular characteristics, including the Pignatti criteria, IDH mutations, TP53 mutations, the 1p/19q deletion, and MGMT methylation, and correlated our findings with progression-free survival (PFS) and overall survival (OS)...
September 7, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28881664/prognostic-micrornas-in-upper-tract-urothelial-carcinoma-multicenter-and-international-validation-study
#19
Laura Izquierdo, Ruth Montalbo, Mercedes Ingelmo-Torres, Carme Mallofré, Miguel Ramírez-Backhaus, Jose Rubio, Antoine G Van der Heijden, Ewout Schaafsma, Antonio Lopez-Beltran, Ana Blanca, Nathan Lawrentschuk, Antonio Alcaraz, Lourdes Mengual
OBJECTIVE: To validate previously discovered miRNAs (miR-31-5p and miR-149-5p) as prognostic factors for UTUC in an independent cohort of UTUC patients. PATIENTS AND METHODS: Multicenter, international and retrospective study of formalin-fixed paraffin-embedded tissue samples from 103 UTUC patients (45 progressing and 58 non-progressing) who underwent radical nephroureterectomy. Total RNA was isolated and reverse transcribed. The expression of target miRNAs (miR-31-5p and miR-149-5p) and the endogenous control miR-218-5p was evaluated in all samples by reverse transcription quantitative PCR...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28878530/oldest-epiphyseal-osteochondroma-in-a-subadult-from-ancient-egypt
#20
Albert Isidro, Josep Maria Catalán, Carme Prat, Ferran Torner
Benign bone tumours are pathologies frequently encountered in archaeological human remains, with the most common being osteoma and osteochondroma. We present the case of a juvenile individual recovered from the Necropolis of Sharuna, Middle Egypt and dated to the end of Old Kingdom and First Intermediate Period of Ancient Egypt (circa 2150 BC), showing an osteochondroma arising from the proximal epiphysis of the right tibia which, in all likelihood, affected the patellar tendon in life. Osteochondromas are usually discovered during childhood and adolescence...
August 2017: Journal of Clinical Orthopaedics and Trauma
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