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https://www.readbyqxmd.com/read/29220325/direction-modulation-of-muscle-synergies-in-a-hand-reaching-task
#1
Sharon Israely, Gerry Leisman, Chay Machluf, Tal Shnitzer, Eli Carmeli
Functional tasks of the upper extremity can be executed by a variety of muscular patterns, independent of the direction, speed and load of the task. This large number of degrees of freedom imposes a significant control burden on the CNS. Previous studies suggested that the human cortex synchronizes a discrete number of neural functional units within the brainstem and spinal cord, i.e. muscle synergies, by linearly combining them to execute a great repertoire of movements. Further exploring this control mechanism, we aim to study whether a single set of muscle synergies might be generalized to express movements in different directions...
December 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/29204853/health-indicators-and-social-gradient-in-adolescent-immigrants-health-risk-and-healthcare-experiences
#2
Cheryl Zlotnick, Daphna Birenbaum-Carmeli, Hadass Goldblatt, Yael Dishon, Omer Taychaw, Efrat Shadmi
Few studies have assessed healthcare experiences in apparently healthy adolescents, or whether healthcare attitudes are linked to the two leading adolescent health indicators, smoking and obesity. Even fewer have examined these relationships in adolescent immigrant groups or made comparisons to adolescent non-immigrants. Using a cross-sectional study, healthcare experiences were compared among three groups of adolescents (n = 589) including Russian immigrants (n = 154), Ethiopian immigrants (n = 54), and non-immigrants (n = 381)...
December 5, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29202018/precise-probing-of-residue-roles-by-post-translational-%C3%AE-%C3%AE-c-n-aza-michael-mutagenesis-in-enzyme-active-sites
#3
Jitka Dadová, Kuan-Jung Wu, Patrick G Isenegger, James C Errey, Gonçalo J L Bernardes, Justin M Chalker, Lluís Raich, Carme Rovira, Benjamin G Davis
Biomimicry valuably allows the understanding of the essential chemical components required to recapitulate biological function, yet direct strategies for evaluating the roles of amino acids in proteins can be limited by access to suitable, subtly-altered unnatural variants. Here we describe a strategy for dissecting the role of histidine residues in enzyme active sites using unprecedented, chemical, post-translational side-chain-β,γ C-N bond formation. Installation of dehydroalanine (as a "tag") allowed the testing of nitrogen conjugate nucleophiles in "aza-Michael"-1,4-additions (to "modify")...
November 22, 2017: ACS Central Science
https://www.readbyqxmd.com/read/29194403/inhibitors-of-serine-proteases-from-a-microcystis-sp-bloom-material-collected-from-timurim-reservoir-israel
#4
Rawan Hasan-Amer, Shmuel Carmeli
Two new natural products, micropeptin TR1058 (1) and aeruginosin TR642 (2), were isolated from the hydrophilic extract of bloom material of Microcystis sp. collected from the Timurim water reservoir in Israel. The structures of compounds 1 and 2 were determined using 1D and 2D NMR spectroscopy and HR ESI MS and MS/MS techniques. Micropeptin TR1058 (1) was extremely unstable under the isolation conditions, and several degradation products were identified. NMR analysis of aeruginosin TR642 (2) revealed a mixture of eight isomers, and elucidation of its structure was challenging...
December 1, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29186658/stereoselectivity-of-proline-cyclobutane-amino-acid-containing-peptide-organocatalysts-for-asymmetric-aldol-additions-a-rationale
#5
Ona Illa, Oriol Porcar-Tost, Carme Robledillo, Carlos Elvira, Pau Nolis, Oliver Reiser, Vicenç Branchadell, Rosa M Ortuño
Several α,β,α- or α,γ,α-tripeptides, consisting of a central cyclobutane β- or γ-amino acid being flanked by two (D)- or (L)-proline residues, have been synthesized and tested as organocatalysts in asymmetric aldol additions. High yields and enantioselectivities have been achieved with α,γ,α-tripeptides, being superior to the peptides containing a cyclobutane β-amino acid residue. This can probably be due to their high rigidity, which hinders the peptide catalysts to adopt the proper active conformation...
November 29, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29185694/the-molecular-mechanism-of-substrate-recognition-and-catalysis-of-the-membrane-acyltransferase-pata-from-mycobacteria
#6
Montse Tersa, Lluís Raich, David Albesa-Jové, Beatriz Trastoy, Jacques Prandi, Martine Gilleron, Carme Rovira, Marcelo E Guerin
Glycolipids play a central role in a variety of important biological processes in all living organisms. PatA is a membrane acyltransferase involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIMs), key structural elements and virulence factors of Mycobacterium tuberculosis. PatA catalyzes the transfer of a palmitoyl moiety from palmitoyl-CoA to the 6-position of the mannose ring linked to the 2-position of inositol in PIM1/PIM2. We report here the crystal structure of PatA in the presence of 6-O-palmitoyl-α-D-mannopyranoside, unraveling the acceptor binding mechanism...
November 29, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29180275/-exhaustivity-and-critical-tone-of-the-news-in-print-media-reporting-medical-innovations
#7
Maite Solans-Domènech, Marta Millaret, Núria Radó-Trilla, Johanna Caro-Mendivelso, Carme Carrion, Gaietà Permanyer-Miralda, Joan M V Pons
OBJECTIVE: To quantify how exhaustive and critical were stories reporting medical innovations published in print media and to analyze the characteristics that may be related. METHOD: Content analysis of the newspapers stories related to the discovery, introduction or improvement of a medical innovation through a questionnaire with ten criteria that allows calculating an overall score of exhaustiveness. The critical view was also included. RESULTS: We analyzed 204 newspapers stories that on average obtained a comprehensiveness score of 4...
November 24, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/29164905/correction-to-guzmen-carmeli-and-sharabi-textual-healing-tailor-made-kabbalistic-therapeutics-in-jerusalem
#8
(no author information available yet)
No abstract text is available yet for this article.
November 22, 2017: Anthropology & Medicine
https://www.readbyqxmd.com/read/29157885/development-and-validation-of-a-scoring-system-for-the-identification-of-pleural-exudates-of-cardiac-origin
#9
José M Porcel, Lucia Ferreiro, Carme Civit, Luis Valdés, Aureli Esquerda, Richard W Light, Silvia Bielsa
BACKGROUND: Light's criteria misclassify about 30% of cardiac effusions as exudates, possibly leading to unnecessary testing. Our purpose was to derive and validate a scoring model to effectively identify these falsely categorized cardiac effusions, in the setting of natriuretic peptide lacking data. METHODS: We retrospectively analyzed data from 3182 patients with exudative pleural effusions based on Light's criteria, of whom 276 had heart failure (derivation set)...
November 17, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29155810/regulation-of-transcription-elongation-in-response-to-osmostress
#10
Andrea Silva, Santiago Cavero, Victoria Sarah, Carme Solé, René Böttcher, Sebastián Chávez, Francesc Posas, Eulàlia de Nadal
Cells trigger massive changes in gene expression upon environmental fluctuations. The Hog1 stress-activated protein kinase (SAPK) is an important regulator of the transcriptional activation program that maximizes cell fitness when yeast cells are exposed to osmostress. Besides being associated with transcription factors bound at target promoters to stimulate transcriptional initiation, activated Hog1 behaves as a transcriptional elongation factor that is selective for stress-responsive genes. Here, we provide insights into how this signaling kinase functions in transcription elongation...
November 20, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29153726/bioindicators-for-monitoring-marine-litter-ingestion-and-its-impacts-on-mediterranean-biodiversity
#11
REVIEW
Maria Cristina Fossi, Cristina Pedà, Montserrat Compa, Catherine Tsangaris, Carme Alomar, Francoise Claro, Christos Ioakeimidis, Francois Galgani, Tatjana Hema, Salud Deudero, Teresa Romeo, Pietro Battaglia, Franco Andaloro, Ilaria Caliani, Silvia Casini, Cristina Panti, Matteo Baini
The Mediterranean Sea has been described as one of the most affected areas by marine litter in the world. Although effects on organisms from marine plastic litter ingestion have been investigated in several oceanic areas, there is still a lack of information from the Mediterranean Sea. The main objectives of this paper are to review current knowledge on the impact of marine litter on Mediterranean biodiversity, to define selection criteria for choosing marine organisms suitable for use as bioindicator species, and to propose a methodological approach to assessing the harm related to marine litter ingestion in several Mediterranean habitats and sub-regions...
November 16, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29124460/medical-egg-freezing-the-importance-of-a-patient-centered-approach-to-fertility-preservation
#12
Marcia C Inhorn, Daphna Birenbaum-Carmeli, Lynn M Westphal, Joseph Doyle, Norbert Gleicher, Dror Meirow, Hila Raanani, Martha Dirnfeld, Pasquale Patrizio
PURPOSE: This binational qualitative study of medical egg freezing (MEF) examined women's motivations and experiences, including their perceived needs for patient-centered care in the midst of fertility- and life-threatening diagnoses. METHODS: Forty-five women who had undertaken MEF were interviewed in the USA (33 women) and in Israel (12 women) between June 2014 and August 2016. Interviews lasted approximately 1 h and were conducted by two senior medical anthropologists, one in each country...
November 9, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29121539/clinical-and-biological-significance-of-isolated-y-chromosome-loss-in-myelodysplastic-syndromes-and-chronic-myelomonocytic-leukemia-a-report-from-the-spanish-mds-group
#13
Meritxell Nomdedeu, Arturo Pereira, Xavier Calvo, Joan Colomer, Francesc Sole, Amparo Arias, Candida Gomez, Elisa Luño, Jose Cervera, Montserrat Arnan, Helena Pomares, Fernando Ramos, Itziar Oiartzabal, Blanca Espinet, Carme Pedro, Beatriz Arrizabalaga, María Laura Blanco, Mar Tormo, Jesus Maria Hernandez-Rivas, María Díez-Campelo, Margarita Ortega, David Valcárcel, Maria-Teresa Cedena, Rosa Collado, Javier Grau, Isabel Granada, Guillermo Sanz, Elias Campo, Jordi Esteve, Dolors Costa
Isolate loss of chromosome Y (-Y) in myelodysplastic syndromes (MDS) is associated to a better outcome but it is also well described as an age-related phenomenon. In this study we aimed to analyze the prognostic impact of -Y in the context of the IPSS-R cytogenetic classification, evaluate the clinical significance of the percentage of metaphases with isolated -Y, and test whether finding -Y may predispose to over-diagnose MDS in patients with borderline morphological features. We evaluated 3581 male patients from the Spanish MDS Registry with a diagnosis of MDS or chronic myelomonocytic leukemia (CMML)...
December 2017: Leukemia Research
https://www.readbyqxmd.com/read/29121511/medical-egg-freezing-and-cancer-patients-hopes-fertility-preservation-at-the-intersection-of-life-and-death
#14
Marcia C Inhorn, Daphna Birenbaum-Carmeli, Pasquale Patrizio
Egg freezing (i.e., oocyte cryopreservation) is a new reproductive technology that allows women's eggs to be frozen and stored for future use. Over the past five years, so-called "medical egg freezing" (MEF) has begun to play a major role as a form of fertility preservation for young women with cancer and other fertility-threatening medical conditions. Indeed, women who are candidates for MEF are often facing the "double jeopardy" of fertility loss and potential death. In this article, we examine the experiences of the first generation of women to use MEF in the United States and Israel, two countries where experimental use of MEF began early, and where MEF is now offered clinically in many in vitro fertilization (IVF) clinics...
October 31, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29116388/the-evolutionarily-conserved-factor-sus1-eny2-plays-a-role-in-telomere-length-maintenance
#15
Amparo Galán, Encar García-Oliver, Carme Nuño-Cabanes, Linda Rubinstein, Martin Kupiec, Susana Rodríguez-Navarro
Sus1 is a conserved protein involved in histone H2B de-ubiquitination and mRNA export from the nucleus in eukaryotes. Previous studies implicated Sus1 partners in genome integrity including telomere homeostasis. However, the implication of Sus1 in telomere maintenance remains largely unknown. In this study, we found that yeast Sus1 interacts physically and genetically with factors involved in telomere maintenance and its absence leads to elongated telomeres. Deletion of several of Sus1's partners also leads to longer telomeres...
November 7, 2017: Current Genetics
https://www.readbyqxmd.com/read/29111385/jnk1-inhibition-by-licochalcone-a-leads-to-neuronal-protection-against-excitotoxic-insults-derived-of-kainic-acid
#16
Oriol Busquets, Miren Ettcheto, Ester Verdaguer, Rubén Dario, Carme Auladell, Carlos Beas-Zarate, Jaume Folch, Antoni Camins
The mitogen-activated protein kinase family (MAPK) is an important group of enzymes involved in cellular responses to diverse external stimuli. One of the members of this family is the c-Jun-N-terminal kinase (JNK). The activation of the JNK pathway has been largely associated with the pathogenesis that occurs in epilepsy and neurodegeneration. Kainic acid (KA) administration in rodents is an experimental approach that induces status epilepticus (SE) and replicates many of the phenomenological features of human temporal lobe epilepsy (TLE)...
October 27, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29106544/effects-of-adult-female-rat-androgenization-on-brain-morphology-and-metabolomic-profile
#17
Carmen Perez-Laso, Sebastián Cerdan, Carme Junque, Ángel Gómez, Esperanza Ortega, Mireia Mora, Carlos Avendaño, Esther Gómez-Gil, María Cruz Rodríguez Del Cerro, Antonio Guillamon
Androgenization in adult natal women, as in transsexual men (TM), affects brain cortical thickness and the volume of subcortical structures. In order to understand the mechanism underlying these changes we have developed an adult female rat model of androgenization. Magnetic resonance imaging and spectroscopy were used to monitor brain volume changes, white matter microstructure and ex vivo metabolic profiles over 32 days in androgenized and control subjects. Supraphysiological doses of testosterone prevents aging decrease of fractional anisotropy values, decreased general cortical volume and the relative concentrations of glutamine (Gln) and myo-Inositol (mI)...
July 6, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29106481/blood-concentrations-of-persistent-organic-pollutants-and-unhealthy-metabolic-phenotypes-in-normal-weight-overweight-and-obese-individuals
#18
Magda Gasull, Conxa Castell, Natàlia Pallarès, Carme Miret, José Pumarega, María Te Llez-Plaza, Tomàs López, Jordi Salas-Salvadó, Duk-Hee Lee, Albert Goday, Miquel Porta
Factors underlying metabolic phenotypes, such as the metabolically healthy but obese phenotype, remain unclear. Differences in metabolic phenotypes -particularly, among individuals with a similar body mass index- could be related to concentrations of persistent organic pollutants (POPs). No studies have analyzed POPs and metabolic phenotypes in normal-weight persons. The authors investigated the relationships between serum concentrations of POPs and metabolic phenotypes in 860 normal-weight, overweight, and obese participants in the 2002 Catalan Health Interview Survey (Spain)...
June 30, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29104699/the-application-of-titanium-dioxide-zinc-oxide-fullerene-and-graphene-nanoparticles-in-photodynamic-therapy
#19
REVIEW
Zahraa Youssef, Régis Vanderesse, Ludovic Colombeau, Francis Baros, Thibault Roques-Carmes, Céline Frochot, Habibah Wahab, Joumana Toufaily, Tayssir Hamieh, Samir Acherar, Amirah Mohd Gazzali
Nanoparticles (NPs) have been shown to have good ability to improve the targeting and delivery of therapeutics. In the field of photodynamic therapy (PDT), this targeting advantage of NPs could help ensure drug delivery at specific sites. Among the commonly reported NPs for PDT applications, NPs from zinc oxide, titanium dioxide, and fullerene are commonly reported. In addition, graphene has also been reported to be used as NPs albeit being relatively new to this field. In this context, the present review is organized by these different NPs and contains numerous research works related to PDT applications...
2017: Cancer Nanotechnology
https://www.readbyqxmd.com/read/29067628/two-year-follow-up-of-fall-prediction-among-older-adults-in-an-independent-living-community
#20
Oz Zur, Yitshal Berner, Yair Ohel, Eli Carmeli
Adults over the age of 70 are at risk of falls. Early detection of risk of falls can suggest early interventions. In this study, we attempted to determine valid clinical tests that can differentiate older individuals who are at risk of falling. Older adults from an independent-living community volunteered to participate in this descriptive, cohort study. They were administered the Berg Balance Scale (BBS), Zur Balance Scale (ZBS); Head Shaking Nystagmus Head Impulse Test, Dynamic Visual Acuity, and the Hallpike maneuver for evaluating benign paroxysmal positional vertigo (BPPV); a questionnaire including sociodemographics and a health characteristics survey...
October 25, 2017: Advances in Experimental Medicine and Biology
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