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https://www.readbyqxmd.com/read/28328090/bronchiolitis-score-of-sant-joan-de-d%C3%A3-u-brosjod-score-validation-and-usefulness
#1
Mònica Balaguer, Carme Alejandre, David Vila, Elisabeth Esteban, Josep L Carrasco, Francisco José Cambra, Iolanda Jordan
OBJECTIVE: To validate the bronchiolitis score of Sant Joan de Déu (BROSJOD) and to examine the previously defined scoring cutoff. PATIENTS AND METHODS: Prospective, observational study. BROSJOD scoring was done by two independent physicians (at admission, 24 and 48 hr). Internal consistency of the score was assessed using Cronbach's α. To determine inter-rater reliability, the concordance correlation coefficient estimated as an intraclass correlation coefficient (CCC) and limits of agreement estimated as the 90% total deviation index (TDI) were estimated...
April 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28327501/accurate-determination-of-the-frequency-response-function-of-submerged-and-confined-structures-by-using-pzt-patches%C3%A2
#2
Alexandre Presas, David Valentin, Eduard Egusquiza, Carme Valero, Mònica Egusquiza, Matias Bossio
To accurately determine the dynamic response of a structure is of relevant interest in many engineering applications. Particularly, it is of paramount importance to determine the Frequency Response Function (FRF) for structures subjected to dynamic loads in order to avoid resonance and fatigue problems that can drastically reduce their useful life. One challenging case is the experimental determination of the FRF of submerged and confined structures, such as hydraulic turbines, which are greatly affected by dynamic problems as reported in many cases in the past...
March 22, 2017: Sensors
https://www.readbyqxmd.com/read/28325776/noninvasive-respiratory-support-during-pediatric-ground-transport-implementation-of-a-safe-and-feasible-procedure
#3
Nuria Millán, Carme Alejandre, Aina Martinez-Planas, Josep Caritg, Elisabeth Esteban, Martí Pons-Òdena
BACKGROUND: The purpose of this work was to determine the safety and feasibility of noninvasive support in children with acute respiratory failure (ARF) during interhospital ground transport. METHODS: This was a prospective, single-center observational clinical study in the pediatric transport unit of a tertiary-care pediatric hospital. We included all subjects with ARF transported from November 2010 to March 2013. A specific noninvasive support protocol was used for all cases...
March 21, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28314812/improvement-in-arm-and-hand-function-after-a-stroke-with-task-oriented-training
#4
Sharon Israely, Gerry Leisman, Eli Carmeli
A man aged 77 years sustained a left-hemisphere stroke with right hemiparesis. After spending 10 days in the hospital, he was referred to an area rehabilitation centre. There he carried out daily physical, occupational and speech therapy, with an emphasis on task-oriented treatment. The patient's upper-extremity motor performance was evaluated at admission to the rehabilitation centre and before leaving the hospital by 3 different measurement tools: the upper-extremity motor part of the Fugl-Meyer assessment scale, electromyography in hand-reach and grasp and object manipulation and handwriting tasks...
March 17, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28303428/outcomes-of-laparoscopic-and-robotic-partial-nephrectomy-for-large-4%C3%A2-cm-kidney-tumors-systematic-review-and-meta-analysis
#5
REVIEW
Nicola Pavan, Ithaar H Derweesh, Carme Maria Mir, Giacomo Novara, Lance J Hampton, Matteo Ferro, Sisto Perdonà, Dipen J Parekh, Francesco Porpiglia, Riccardo Autorino
PURPOSE: The aim of this study was to assess the outcomes of minimally invasive (laparoscopic and robotic) partial nephrectomy (MIPN) for large renal masses. MATERIALS AND METHODS: A systematic literature review was performed up to September 2016 using multiple search engines to identify studies comparing MIPN for tumors larger than 4 cm (>cT1a) with MIPN for tumors smaller than 4 cm (cT1a). The preferred reporting items for systematic reviews and meta-analyses (PRISMA) criteria were used for article selection...
March 16, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28302135/myeloid-c-ebp%C3%AE-deficiency-reshapes-microglial-gene-expression-and-is-protective-in-experimental-autoimmune-encephalomyelitis
#6
Marta Pulido-Salgado, Jose M Vidal-Taboada, Gerardo Garcia Diaz-Barriga, Joan Serratosa, Tony Valente, Paola Castillo, Jonathan Matalonga, Marco Straccia, Josep M Canals, Annabel Valledor, Carme Solà, Josep Saura
BACKGROUND: CCAAT/enhancer binding protein β (C/EBPβ) is a transcription factor that regulates the expression of important pro-inflammatory genes in microglia. Mice deficient for C/EBPβ show protection against excitotoxic and ischemic CNS damage, but the involvement in this neuroprotective effect of the various C/EBPβ-expressing cell types is not solved. Since C/EBPβ-deficient microglia show attenuated neurotoxicity in culture, we hypothesized that specific C/EBPβ deficiency in microglia could be neuroprotective in vivo...
March 16, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28294079/carbapenem-resistant-enterobacteriaceae-a-strategic-roadmap-for-infection-control
#7
N Deborah Friedman, Yehuda Carmeli, Aaron Lea Walton, Mitchell James Schwaber
The incidence of carbapenem-resistant Enterobacteriaceae (CRE) has increased worldwide with great regional variability. Infections caused by these organisms are associated with crude mortality rates of up to 70%. The spread of CRE in healthcare settings is both an important medical problem and a major global public health threat. All countries are at risk of falling victim to the emergence of CRE; therefore, a preparedness plan is required to avoid the catastrophic natural course of this epidemic. Proactive and adequate preventive measures locally, regionally, and nationally are required to contain the spread of these bacteria...
March 15, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28283828/risk-factors-and-peripartum-outcomes-of-failed-epidural-a-prospective-cohort-study
#8
Carmen Bucstain, Gali Garmi, Noah Zafran, Sivan Zuarez-Easton, Julia Carmeli, Raed Salim
PURPOSE: Awareness to rate, risk factors, and the associated peripartum outcomes of failed epidural analgesia (FEA) may improve expectations and labor management. We aimed to identify risk factors for FEA and to examine peripartum outcomes associated with failure. METHODS: A prospective cohort study conducted between March 2015 and August 2015, at a single university medical center. Laboring women at ≥34 weeks, receiving epidural analgesia, were eligible. Pain was evaluated using a 0-10 cm visual analogue scale (VAS)...
March 10, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28283744/serial-block-face-scanning-electron-microscopy-applied-to-study-the-trafficking-of-8d3-coated-gold-nanoparticles-at-the-blood-brain-barrier
#9
Itsaso Cabezón, Elisabet Augé, Manel Bosch, Alison J Beckett, Ian A Prior, Carme Pelegrí, Jordi Vilaplana
Due to the physical and physiological properties of the blood-brain barrier (BBB), the transport of neurotherapeutics from blood to brain is still a pharmaceutical challenge. We previously conducted a series of experiments to explore the potential of the anti-transferrin receptor 8D3 monoclonal antibody (mAb) to transport neurotherapeutics across the BBB. In that study, gold nanoparticles (AuNPs) were coated with the 8D3 antibody and administered intravenously to mice. Transmission electron microscopy was used and a two-dimensional (2D) image analysis was performed to detect the AuNPs in the brain capillary endothelial cells (BCECs) and brain parenchyma...
March 10, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28279442/low-efficacy-of-metronidazole-in-the-eradication-of-blastocystis-hominis-in-symptomatic-patients-case-series-and-systematic-literature-review
#10
Lissette Batista, Josefa Pérez Jove, Mercè Rosinach, Victoria Gonzalo, Empar Sainz, Carme Loras, Montserrat Forné, Maria Esteve, Fernando Fernández-Bañares
INTRODUCTION: Blastocystis hominis (B. hominis) is a protozoan commonly found in the gastrointestinal tract. There are doubts about its clinical significance. Metronidazole (MTZ) is the recommended first-line treatment. MATERIALS AND METHODS: A retrospective review was carried out between 2011 and 2012. A total of 151 samples were randomly selected from 383 samples positive for B. hominis. Inclusion criteria were: suggestive symptoms, treatment indication and microbiological follow-up...
March 6, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/28274621/-socioeconomic-inequalities-in-mammography-screening-in-spanish-women-aged-45-to-69
#11
Gemma Serral, Carme Borrell, Rosa Puigpinós I Riera
OBJECTIVE: To analyse mammography screening in Spanish women aged 45 to 69 according sociodemographic variables and to describe the role of population-based breast cancer screening programmes in terms of variability of said screening. METHODS: Cross-sectional study of the 2011 National Health Survey. The study population includes women living in Spain between late 2011 and early 2012. The weighted sample analysed corresponds to 3,086 women aged 45 to 69. The dependent variables were mammograms and when the last mammogram was performed and why...
March 5, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28273500/anti-inflammatory-role-of-leptin-in-glial-cells-through-p38-mapk-pathway-inhibition
#12
Iván Patraca, Nohora Martínez, Oriol Busquets, Aleix Martí, Ignacio Pedrós, Carlos Beas-Zarate, Miguel Marin, Miren Ettcheto, Francesc Sureda, Carme Auladell, Antoni Camins, Jaume Folch
BACKGROUND: In the present work, we studied the modulatory effect of Leptin (Lep) against pro-inflammatory cytokines, tumour necrosis factor-alpha (TNFα), interleukin 1-beta (IL1β) and interferon-gamma (IFNγ), in primary glial cell cultures. METHODS: Glial cultures were treated with pro-inflammatory cytokines (TNFα, 20ng/ml; IL1β, 20ng/ml; IFNγ 20ng/ml). Cells were pre-treated with Lep 500nM, 1h prior to cytokine treatment. NO released from glial cells was determined using the Griess reaction...
December 9, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28266611/important-fossil-source-contribution-to-brown-carbon-in-beijing-during-winter
#13
Caiqing Yan, Mei Zheng, Carme Bosch, August Andersson, Yury Desyaterik, Amy P Sullivan, Jeffrey L Collett, Bin Zhao, Shuxiao Wang, Kebin He, Örjan Gustafsson
Organic aerosol (OA) constitutes a substantial fraction of fine particles and affects both human health and climate. It is becoming clear that OA absorbs light substantially (hence termed Brown Carbon, BrC), adding uncertainties to global aerosol radiative forcing estimations. The few current radiative-transfer and chemical-transport models that include BrC primarily consider sources from biogenic and biomass combustion. However, radiocarbon fingerprinting here clearly indicates that light-absorbing organic carbon in winter Beijing, the capital of China, is mainly due to fossil sources, which contribute the largest part to organic carbon (OC, 67 ± 3%) and its sub-constituents (water-soluble OC, WSOC: 54 ± 4%, and water-insoluble OC, WIOC: 73 ± 3%)...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28265801/performing-and-declining-pgd-accounts-of-jewish-israeli-women-who-carry-a-brca1-2-mutation-or-partners-of-male-mutation-carriers
#14
Efrat Dagan, Daphna Birenbaum-Carmeli, Eitan Friedman, Baruch Feldman
To describe factors associated with preimplantation genetic diagnosis (PGD) decisions among Jewish Israeli BRCA1/2 carriers or spouses of a male carrier, we contacted all women who initiated PGD consultation for embryonic BRCA1/2 mutation detection at Sheba Medical Center, prior to March 2014. Applying a qualitative approach, we asked women to elaborate on the factors they considered in either opting for PGD or discontinuing the screening procedure. Participants were 18 Jewish Israeli women; 14 were carriers of one of the Ashkenazi founder mutations in BRCA1/2, and four were spouses of male mutation carriers, who underwent at least one cycle of PGD...
March 6, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/28265182/cutaneous-leishmaniasis-in-french-guiana-revising-epidemiology-with-pcr-rflp
#15
Stephane Simon, Mathieu Nacher, Bernard Carme, Celia Basurko, Amaury Roger, Antoine Adenis, Marine Ginouves, Magalie Demar, Pierre Couppie
BACKGROUND: The development of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique for species identification among patients presenting leishmaniasis allowed to better determine the main circulating species in French Guiana. METHODS: A descriptive study of the Leishmania species was identified, and their spatiotemporal distribution was conducted using patient records between 2006 and 2013, with 1017 new cases of leishmaniasis diagnosed...
2017: Tropical Medicine and Health
https://www.readbyqxmd.com/read/28264783/dietary-lipids-differentially-modulate-the-initiation-of-experimental-breast-carcinogenesis-through-their-influence-on-hepatic-xenobiotic-metabolism-and-dna-damage-in-the-mammary-gland
#16
Miguel Ángel Manzanares, Cristina de Miguel, M Carme Ruiz de Villa, Regina M Santella, Eduard Escrich, Montserrat Solanas
Breast cancer is the most common malignancy among women worldwide. In addition to reproductive factors, environmental factors such as nutrition and xenobiotic exposure have a role in the etiology of this malignancy. A stimulating and a potentially protective effect on experimental breast cancer has been previously described for high corn oil and high extra-virgin olive oil diets, respectively. This work investigates the effect of these lipids on the metabolism of 7,12-dimethylbenz(a)anthracene (DMBA), a polycyclic aromatic hydrocarbon that can initiate carcinogenesis and its consequences in an experimental rat breast cancer model...
February 10, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28258474/impact-of-ultrasonography-on-treatment-decision-in-rheumatoid-arthritis-the-impulsar-study
#17
Cèsar Díaz-Torné, Carme Moragues, Elide Toniolo, Carme Geli, Iván Castellví, Patricia Moya, Ignasi Gich, Josep M Llobet
Ultrasonography (US) has shown to be more sensitive than physical examination for diagnosis and assessment of rheumatoid arthritis (RA). It is also a useful approach for accurate monitoring and intensive treatment adjustment. However, there is limited information concerning the impact of US on therapeutic decision-making in routine daily practice. A single-center cross-sectional study in routine daily practice was conducted to determine the percentage of patients with rheumatoid arthritis (RA) in which treatment decision was modified on the basis of results of musculoskeletal ultrasonography...
March 3, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28257245/behavioral-profiles-of-children-with-williams-syndrome-from-spain-and-the-united-states-cross-cultural-similarities-and-differences
#18
Débora Pérez-García, Carme Brun-Gasca, Luis A Pérez-Jurado, Carolyn B Mervis
To identify similarities and differences in the behavioral profile of children with Williams syndrome from Spain (n = 53) and the United States (n = 145), we asked parents of 6- to 14-year-olds with Williams syndrome to complete the Child Behavior Checklist 6-18. The distribution of raw scores was significantly higher for the Spanish sample than the American sample for all of the higher-order factors and half of both the empirically based and Diagnostic and Statistical Manual of Mental Disorders (DSM)-oriented scales...
March 2017: American Journal on Intellectual and Developmental Disabilities
https://www.readbyqxmd.com/read/28253259/scalable-design-of-paired-crispr-guide-rnas-for-genomic-deletion
#19
Carlos Pulido-Quetglas, Estel Aparicio-Prat, Carme Arnan, Taisia Polidori, Toni Hermoso, Emilio Palumbo, Julia Ponomarenko, Roderic Guigo, Rory Johnson
CRISPR-Cas9 technology can be used to engineer precise genomic deletions with pairs of single guide RNAs (sgRNAs). This approach has been widely adopted for diverse applications, from disease modelling of individual loci, to parallelized loss-of-function screens of thousands of regulatory elements. However, no solution has been presented for the unique bioinformatic design requirements of CRISPR deletion. We here present CRISPETa, a pipeline for flexible and scalable paired sgRNA design based on an empirical scoring model...
March 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28241867/securing-an-otl-hns-residency-how-competitive-is-it-comparing-medical-student-perceptions-to-actual-canadian-statistics
#20
E Kay-Rivest, N Varma, G M Scott, J J Manoukian, M Desrosiers, J P Vaccani, L H P Nguyen
BACKGROUND: The residency match is an important event in an aspiring physician's career. Otolaryngology - Head and Neck Surgery (OTL-HNS) is a surgical specialty that has enjoyed high numbers of applicants to its residency programs. However, recent trends in Canada show a decline in first-choice applicants to several surgical fields. Factors thought to influence a medical student's choice include role models, career opportunities and work-life balance. The notion of perceived competitiveness is a factor that has not yet been explored...
February 27, 2017: Journal of Otolaryngology—Head & Neck Surgery
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