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https://www.readbyqxmd.com/read/29456043/colistin-alone-versus-colistin-plus-meropenem-for-treatment-of-severe-infections-caused-by-carbapenem-resistant-gram-negative-bacteria-an-open-label-randomised-controlled-trial
#1
Mical Paul, George L Daikos, Emanuele Durante-Mangoni, Dafna Yahav, Yehuda Carmeli, Yael Dishon Benattar, Anna Skiada, Roberto Andini, Noa Eliakim-Raz, Amir Nutman, Oren Zusman, Anastasia Antoniadou, Pia Clara Pafundi, Amos Adler, Yaakov Dickstein, Ioannis Pavleas, Rosa Zampino, Vered Daitch, Roni Bitterman, Hiba Zayyad, Fidi Koppel, Inbar Levi, Tanya Babich, Lena E Friberg, Johan W Mouton, Ursula Theuretzbacher, Leonard Leibovici
BACKGROUND: Colistin-carbapenem combinations are synergistic in vitro against carbapenem-resistant Gram-negative bacteria. We aimed to test whether combination therapy improves clinical outcomes for adults with infections caused by carbapenem-resistant or carbapenemase-producing Gram-negative bacteria. METHODS: A randomised controlled superiority trial was done in six hospitals in Israel, Greece, and Italy. We included adults with bacteraemia, ventilator-associated pneumonia, hospital-acquired pneumonia, or urosepsis caused by carbapenem-non-susceptible Gram-negative bacteria...
February 15, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29452751/trends-in-cancer-mortality-in-spain-the-influence-of-the-financial-crisis
#2
Josep Ferrando, Laia Palència, Mercè Gotsens, Vanessa Puig-Barrachina, Marc Marí-Dell'Olmo, Maica Rodríguez-Sanz, Xavier Bartoll, Carme Borrell
OBJECTIVE: To determine if the onset of the economic crisis in Spain affected cancer mortality and mortality trends. METHOD: We conducted a longitudinal ecological study based on all cancer-related deaths and on specific types of cancer (lung, colon, breast and prostate) in Spain between 2000 and 2013. We computed age-standardised mortality rates in men and women, and fit mixed Poisson models to analyse the effect of the crisis on cancer mortality and trends therein...
February 13, 2018: Gaceta Sanitaria
https://www.readbyqxmd.com/read/29450940/statistical-inference-in-brain-graphs-using-threshold-free-network-based-statistics
#3
Hugo C Baggio, Alexandra Abos, Barbara Segura, Anna Campabadal, Anna Garcia-Diaz, Carme Uribe, Yaroslau Compta, Maria Jose Marti, Francesc Valldeoriola, Carme Junque
The description of brain networks as graphs where nodes represent different brain regions and edges represent a measure of connectivity between a pair of nodes is an increasingly used approach in neuroimaging research. The development of powerful methods for edge-wise group-level statistical inference in brain graphs while controlling for multiple-testing associated false-positive rates, however, remains a difficult task. In this study, we use simulated data to assess the properties of threshold-free network-based statistics (TFNBS)...
February 15, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29449235/amazing-idea-blind-medical-school-and-carms-applications-of-all-applicant-names-until-interview-selections-are-complete
#4
Ankit Kapur
No abstract text is available yet for this article.
February 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29449187/cortical-atrophy-patterns-in-early-parkinson-s-disease-patients-using-hierarchical-cluster-analysis
#5
Carme Uribe, Barbara Segura, Hugo Cesar Baggio, Alexandra Abos, Anna Isabel Garcia-Diaz, Anna Campabadal, Maria Jose Marti, Francesc Valldeoriola, Yaroslau Compta, Eduard Tolosa, Carme Junque
INTRODUCTION: Cortical brain atrophy detectable with MRI in non-demented advanced Parkinson's disease (PD) is well characterized, but its presence in early disease stages is still under debate. We aimed to investigate cortical atrophy patterns in a large sample of early untreated PD patients using a hypothesis-free data-driven approach. METHODS: Seventy-seven de novo PD patients and 50 controls from the Parkinson's Progression Marker Initiative database with T1-weighted images in a 3-tesla Siemens scanner were included in this study...
February 8, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29444621/excitotoxicity-in-the-pathogenesis-of-neurological-and-psychiatric-disorders-therapeutic-implications
#6
Jordi Olloquequi, Elizabeth Cornejo-Córdova, Ester Verdaguer, Francesc X Soriano, Octavio Binvignat, Carme Auladell, Antoni Camins
Neurological and psychiatric disorders are leading contributors to the global disease burden, having a serious impact on the quality of life of both patients and their relatives. Although the molecular events underlying these heterogeneous diseases remain poorly understood, some studies have raised the idea of common mechanisms involved. In excitotoxicity, there is an excessive activation of glutamate receptors by excitatory amino acids, leading to neuronal damage. Thus, the excessive release of glutamate can lead to a dysregulation of Ca 2+ homeostasis, triggering the production of free radicals and oxidative stress, mitochondrial dysfunction and eventually cell death...
February 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29443387/predictors-of-early-left-ventricular-systolic-dysfunction-in-dmd-patients
#7
Raphael Henrique Déa Cirino, Rosana Herminia Scola, Renata Dal-Prá Ducci, Ana Cristina Camarozano Wermelinger, Claudia Suemi Kamoi Kay, Paulo José Lorenzoni, Lineu Cesar Werneck, Eliane Ribeiro Carmes, Claudio Leinig Pereira da Cunha
INTRODUCTION: Early detection of left ventricular systolic dysfunction (LVSD) is important for therapeutic strategies for Duchenne muscular dystrophy (DMD) patients. We analyzed the myocardial strain by echocardiography for the early detection of LVSD and determined the predictors of early LVSD. METHODS: Cross-sectional study of forty DMD patients with normal left ventricular ejection fraction. Global longitudinal strain (GLS) was used to analyse subtle disturbances in the longitudinal contraction of the myocardium...
February 14, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29429029/very-high-frequency-oscillations-of-heart-rate-variability-in-healthy-humans-and-in-patients-with-cardiovascular-autonomic-neuropathy
#8
Mario Estévez-Báez, Calixto Machado, Julio Montes-Brown, Javier Jas-García, Gerry Leisman, Adam Schiavi, Andrés Machado-García, Claudia Carricarte-Naranjo, Eli Carmeli
Literature reports on the very high frequency (VHF) range of 0.4-0.9 Hz in heart rate variability (HRV) are scanty. The VHF presence in cardiac transplant patients and other conditions associated with reduced vagal influence on the heart encouraged us to explore this spectral band in healthy subjects and in patients diagnosed with cardiac autonomic neuropathy (CAN), and to assess the potential clinical value of some VHF indices. The study included 80 healthy controls and 48 patients with spinocerebellar ataxia type 2 (SCA2) with CAN...
February 11, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29427279/identification-of-intermediates-acute-toxicity-removal-and-kinetics-investigation-to-the-ametryn-treatment-by-direct-photolysis-uv254-uv254-h2o2-fenton-and-photo-fenton-processes
#9
Dirce Martins de Oliveira, Rodrigo Pereira Cavalcante, Lucas de Melo da Silva, Carme Sans, Santiago Esplugas, Silvio Cesar de Oliveira, Amilcar Machulek Junior
This paper reports the degradation of 10 mg L-1 Ametryn solution with different advanced oxidation processes and by ultraviolet (UV254) irradiation alone with the main objective of reducing acute toxicity and increase biodegradability. The investigated factors included Fe2+ and H2O2 concentrations. The effectiveness of the UV254 and UV254/H2O2 processes were investigated using a low-pressure mercury UV lamp (254 nm). Photo-Fenton process was explored using a blacklight blue lamp (BLB, λ = 365 nm). The UV254 irradiation process achieved complete degradation of Ametryn solution after 60 min...
February 9, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29404958/peripheral-and-central-effects-of-memantine-in-a-mixed-preclinical-mice-model-of-obesity-and-familial-alzheimer-s-disease
#10
Miren Ettcheto, Elena Sánchez-López, Yaiza Gómez-Mínguez, Henrry Cabrera, Oriol Busquets, Carlos Beas-Zarate, Maria Luisa García, Eva Carro, Gemma Casadesus, Carme Auladell, Manuel Vázquez Carrera, Jaume Folch, Antoni Camins
There is growing evidence that obesity associated with type 2 diabetes mellitus (T2DM) and aging are risk factors for the development of Alzheimer's disease (AD). However, the molecular mechanisms through which obesity interacts with β-amyloid (Aβ) to promote cognitive decline remains poorly understood. Memantine (MEM), a N-methyl-D-aspartate receptor antagonist, is currently used for the treatment of AD. Nonetheless, few studies have reported its effects on genetic preclinical models of this neurodegenerative disease exacerbated with high-fat diet (HFD)-induced obesity...
February 5, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29401432/dynamic-and-irregular-distribution-of-ryr2-clusters-in-the-periphery-of-live-ventricular-myocytes
#11
Florian Hiess, Pascal Detampel, Carme Nolla-Colomer, Alex Vallmitjana, Anutosh Ganguly, Matthias Amrein, Henk E D J Ter Keurs, Raul Benítez, Leif Hove-Madsen, S R Wayne Chen
Cardiac ryanodine receptors (RyR2s) are Ca2+ release channels clustering in the sarcoplasmic reticulum membrane. These clusters are believed to be the elementary units of Ca2+ release. The distribution of these Ca2+ release units plays a critical role in determining the spatio-temporal profile and stability of sarcoplasmic reticulum Ca2+ release. RyR2 clusters located in the interior of cardiomyocytes are arranged in highly ordered arrays. However, little is known about the distribution and function of RyR2 clusters in the periphery of cardiomyocytes...
January 23, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29397390/neuromuscular-synergies-in-motor-control-in-normal-and-poststroke-individuals
#12
Sharon Israely, Gerry Leisman, Eli Carmeli
Muscle synergies are proposed to function as motor primitives that are modulated by frontal brain areas to construct a large repertoire of movement. This paper reviews the history of the development of our current theoretical understanding of nervous system-based motor control mechanisms and more specifically the concept of muscle synergies. Computational models of muscle synergies, especially the nonnegative matrix factorization algorithm, are discussed with specific reference to the changes in synergy control post-central nervous system (CNS) lesions...
February 5, 2018: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/29390914/acceptance-or-decline-of-requests-to-review-manuscripts-a-gender-based-approach-from-a-public-health-journal
#13
M Felícitas Domínguez-Berjón, Pere Godoy, Alberto Ruano-Ravina, Miguel Ángel Negrín, Carmen Vives-Cases, Carlos Álvarez-Dardet, Clara Bermúdez-Tamayo, M José López, Glòria Pérez, Carme Borrell
BACKGROUND: Peer review in the scientific publication is widely used as a method to identify valuable knowledge. Editors have the task of selecting appropriate reviewers. We assessed the reasons given by potential reviewers for declining a request to review and the factors associated with acceptance, taking into account the difference in the sex of the reviewer. METHODS: Descriptive study of the review requests from a public health journal (Gaceta Sanitaria) with an enforced gender policy...
February 1, 2018: Accountability in Research
https://www.readbyqxmd.com/read/29384599/combination-video-assisted-mediastinoscopic-lymphadenectomy-and-transcervical-thoracoscopy
#14
Juan Carlos Trujillo-Reyes, Elisabeth Martínez-Téllez, Ramón Rami-Porta, Carme Obiols, Sergi Call, Josep Belda-Sanchis
Surgical staging of lung and pleural cancers is crucial for planning treatment and assessing prognosis. In some cases, we need to explore both the mediastinum and the pleural cavity to confirm or rule out tumor dissemination. The combination of video-assisted mediastinoscopic lymphadenectomy (VAMLA) and thoracoscopy through a single transcervical incision allows the surgeon to widen the range of the exploration and improve the staging for lung and pleural cancers.  VAMLA consists of complete removal of the mediastinal fat and lymph nodes of the subcarinal space, the right paratracheal and pretracheal areas, and the left paratracheal space...
January 18, 2018: Multimedia Manual of Cardiothoracic Surgery: MMCTS
https://www.readbyqxmd.com/read/29382127/the-implication-of-the-brain-insulin-receptor-in-late-onset-alzheimer-s-disease-dementia
#15
REVIEW
Jaume Folch, Miren Ettcheto, Oriol Busquets, Elena Sánchez-López, Rubén D Castro-Torres, Ester Verdaguer, Patricia R Manzine, Saghar Rabiei Poor, María Luisa García, Jordi Olloquequi, Carlos Beas-Zarate, Carme Auladell, Antoni Camins
Alzheimer's disease (AD) is progressive neurodegenerative disorder characterized by brain accumulation of the amyloid β peptide (Aβ), which form senile plaques, neurofibrillary tangles (NFT) and, eventually, neurodegeneration and cognitive impairment. Interestingly, epidemiological studies have described a relationship between type 2 diabetes mellitus (T2DM) and this pathology, being one of the risk factors for the development of AD pathogenesis. Information as it is, it would point out that, impairment in insulin signalling and glucose metabolism, in central as well as peripheral systems, would be one of the reasons for the cognitive decline...
January 29, 2018: Pharmaceuticals
https://www.readbyqxmd.com/read/29374818/long-term-effectiveness-of-laparoscopic-conversion-of-sleeve-gastrectomy-to-a-biliopancreatic-diversion-with-a-duodenal-switch-or-a-roux-en-y-gastric-bypass-due-to-weight-loss-failure
#16
Orit Shimon, Andrei Keidar, Ran Orgad, Renana Yemini, Idan Carmeli
BACKGROUND: Gastroesophageal reflux disease and inadequate weight loss (IWL) are long-term complications of laparoscopic sleeve gastrectomy (LSG) and indications for a laparoscopic conversion to an alternative bariatric procedure. The aim of this study is to report the long-term outcomes of biliopancreatic diversion with a duodenal switch (DS) or a Roux-en-Y gastric bypass (RYGB) as conversion procedures for weight loss failure after LSG. METHODS: The data of all patients who underwent post-LSG conversion to either a RYGB or a DS at our institution between November 2006 and May 2016 was retrospectively analyzed...
January 27, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29374577/evaluation-of-linezolid-or-cotrimoxazole-in-combination-with-rifampicin-as-alternative-oral-treatments-based-on-an-in-vitro-pharmacodynamic-model-of-staphylococcal-biofilm
#17
Cristina El Haj, Oscar Murillo, Alba Ribera, Nuria Lloberas, Joan Gómez-Junyent, Fe Tubau, Pere Fontova, Carme Cabellos, Javier Ariza
BACKGROUND: Linezolid or cotrimoxazole plus rifampicin (RIF) are alternative oral treatments for staphylococcal prosthetic joint infections when fluoroquinolones are not possible to use, but there is limited evidence about its activity. OBJECTIVES: We evaluated the efficacy of linezolid (LZD) and cotrimoxazole (SXT) alone and in combination with RIF against Staphylococcus aureus in an in vitro pharmacokinetic/pharmacodynamic biofilm model. METHODS: Using the CDC Biofilm Reactor® system, simulated regimens of LZD (600 mg q12h), SXT (160/800 mg q8h) and levofloxacin (LVX, 750 mg/day) alone and in combination with RIF (600 mg/day) were evaluated against one MSSA and one MRSA strain...
January 25, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29373475/lessons-from-an-outbreak-of-varicella-infection-in-pediatric-hemato-oncology-patients
#18
Michal Manistarski, Dror Levin, Rina Dvir, Sivan Berger-Achituv, Hila Rosenfeld Keidar, Galia Grisaru-Soen, Yehuda Carmeli, Ronit Elhasid
BACKGROUND: Immunocompromized patients exposed to varicella may experience significant morbidity and a 7% mortality rate. Management and outcome of an outbreak of varicella infection among hospitalized pediatric hemato-oncology patients using the guidelines of the American Academy of Pediatrics Committee on Infectious Diseases is presented. PATIENTS AND METHODS: This retrospective study describes an outbreak of varicella infection between February 2011 and June 2011...
January 25, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29370176/patterns-of-sedentary-behavior-in-overweight-and-moderately-obese-users-of-the-catalan-primary-health-care-system
#19
Elena Martínez-Ramos, Angela-Maria Beltran, Carme Martín-Borràs, Lourdes Lasaosa-Medina, Jordi Real, José-Manuel Trujillo, Mercè Solà-Gonfaus, Elisa Puigdomenech, Eva Castillo-Ramos, Anna Puig-Ribera, Maria Giné-Garriga, Noemi Serra-Paya, Beatriz Rodriguez-Roca, Ana Gascón-Catalán, Carlos Martín-Cantera
BACKGROUND AND OBJECTIVES: Prolonged sitting time (ST) has negative consequences on health. Changing this behavior is paramount in overweight/obese individuals because they are more sedentary than those with normal weight. The aim of the study was to establish the pattern of sedentary behavior and its relationship to health, socio-demographics, occupation, and education level in Catalan overweight/obese individuals. METHODS: A descriptive study was performed at 25 healthcare centers in Catalonia (Spain) with 464 overweight/moderately obese patients, aged25 to 65 years...
2018: PloS One
https://www.readbyqxmd.com/read/29361021/closing-in-on-the-reservoir-proactive-case-detection-in-high-risk-groups-as-a-strategy-to-detect-plasmodium-falciparum-asymptomatic-carriers-in-cambodia
#20
Gabriele Rossi, Lieven Vernaeve, Rafael Van den Bergh, Chea Nguon, Mark Debackere, Carme Abello Peiri, Vuthea Van, Nimol Khim, Saorin Kim, Rotha Eam, Malen Ken, Chanra Khean, Martin De Smet, Didier Menard, Jean-Marie Kindermans
Background: In the frame of elimination strategies of Plasmodium falciparum (Pf), active case detection has been recommended as complementary approach to the existing passive case detection programs. We trialed a polymerase chain reaction (PCR)-based active detection strategy targeting asymptomatic individuals, named proactive case detection (PACD), with the aim of assessing its feasibility, the extra yield of Pf infections, and the at-risk population for Pf carriage status. Methods: A pilot of PACD was conducted in 3 villages in Chey Saen district (Preah Vihear province, Cambodia), from December 2015 to March 2016...
January 18, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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