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https://www.readbyqxmd.com/read/28633600/direct-comparison-of-tricyclic-and-serotonin-reuptake-inhibitor-antidepressants-in-randomized-head-to-head-trials-in-acute-major-depression-systematic-review-and-meta-analysis
#1
Juan Undurraga, Ross J Baldessarini
BACKGROUND: A comparison across trials conducted over several decades suggested superior efficacy of tricyclic antidepressants (TCAs) over selective serotonin-reuptake inhibitors (SSRIs). However, this outcome may reflect a selective secular decline of responses after randomization to placebo. Remaining uncertainty encouraged direct comparison of the drug-types in trials involving randomized, head-to-head comparisons. METHODS: We systematically identified reports of randomized trials of TCAs versus SSRIs for major depression in several digital databases, and applied standard meta-analytic and multiple-factor regression methods to analyze and pool the findings...
June 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28631331/missing-data-in-clinical-trials-control-based-mean-imputation-and-sensitivity-analysis
#2
Devan V Mehrotra, Fang Liu, Thomas Permutt
In some randomized (drug versus placebo) clinical trials, the estimand of interest is the between-treatment difference in population means of a clinical endpoint that is free from the confounding effects of "rescue" medication (e.g., HbA1c change from baseline at 24 weeks that would be observed without rescue medication regardless of whether or when the assigned treatment was discontinued). In such settings, a missing data problem arises if some patients prematurely discontinue from the trial or initiate rescue medication while in the trial, the latter necessitating the discarding of post-rescue data...
June 20, 2017: Pharmaceutical Statistics
https://www.readbyqxmd.com/read/28629259/bayesian-analysis-of-longitudinal-dyadic-data-with-informative-missing-data-using-a-dyadic-shared-parameter-model
#3
Jaeil Ahn, Satoshi Morita, Wenyi Wang, Ying Yuan
Analyzing longitudinal dyadic data is a challenging task due to the complicated correlations from repeated measurements and within-dyad interdependence, as well as potentially informative (or non-ignorable) missing data. We propose a dyadic shared-parameter model to analyze longitudinal dyadic data with ordinal outcomes and informative intermittent missing data and dropouts. We model the longitudinal measurement process using a proportional odds model, which accommodates the within-dyad interdependence using the concept of the actor-partner interdependence effects, as well as dyad-specific random effects...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/28628763/patients-perspectives-on-treatment-with-metacognitive-training-for-depression-d-mct-results-on-acceptability
#4
Lena Jelinek, Steffen Moritz, Marit Hauschildt
BACKGROUND: Our understanding of how patients perceive and evaluate treatment for depression is scarce. Because dropout rates are high among individuals in treatment for depression, it is necessary to expand the focus of research to patients' perspectives on the treatment they receive. The aim of the two studies presented was to evaluate patient acceptance of Metacognitive Training for Depression (D-MCT), a highly standardized group intervention. METHODS: Acceptability was evaluated in an open case series (Study 1, N = 70) and a randomized controlled trial (RCT; Study 2, N = 84)...
June 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28624898/improving-diabetes-care-at-primary-care-level-with-a-multistrategic-approach-results-of-the-diaprem-programme
#5
Mariana Prestes, Maria A Gayarre, Jorge F Elgart, Lorena Gonzalez, Enzo Rucci, Jose M Paganini, Juan J Gagliardino
AIM: To present results, 1 year postimplementation at primary care level, of an integrated diabetes care programme including systemic changes, education, registry (clinical, metabolic, and therapeutic indicators), and disease management (DIAPREM). METHODS: We randomly selected and trained 15 physicians and 15 nurses from primary care units of La Matanza County (intervention-IG) and another 15 physicians/nurses to participate as controls (control-CG). Each physician-nurse team controlled and followed up 10 patients with type 2 diabetes for 1 year; both groups used structured medical records...
June 17, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28623732/safety-and-acceptability-of-transcranial-direct-current-stimulation-for-the-acute-treatment-of-major-depressive-episodes-analysis-of-individual-patient-data
#6
Adriano H Moffa, André R Brunoni, Felipe Fregni, Ulrich Palm, Frank Padberg, Daniel M Blumberger, Zafiris J Daskalakis, Djamila Bennabi, Emmanuel Haffen, Angelo Alonzo, Colleen K Loo
BACKGROUND: Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation modality that has been increasingly used for major depressive disorder (MDD) treatment. Although studies in healthy volunteers showed that the technique is well-tolerated, tDCS safety and acceptability have not been sufficiently explored in patients with MDD. METHODS: We collected individual patient data from 6 randomized clinical trials that had been previously identified in a systematic review and meta-analysis...
June 13, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28621654/diabetes-risk-reduction-in-primary-care-evaluation-of-the-ontario-primary-care-diabetes-prevention-program
#7
Michael Hillmer, Guillermo A Sandoval, James A Elliott, Meera Jain, Tiffany Barker, Amy Prisniak, Stoni Astley, Laura Rosella
OBJECTIVES: Lifestyle interventions can reduce type 2 diabetes risk. The Primary Care Diabetes Prevention Program (PCDPP) was implemented by the Government of Ontario to lower diabetes risk. This study first evaluated the program, and second used a validated tool to estimate a potential population impact if the program were implemented more broadly in the province. METHODS: PCDPP was implemented in six primary care settings serving communities with high mortality risk due to chronic diseases...
June 16, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28618812/auditory-feature-representation-using-convolutional-restricted-boltzmann-machine-and-teager-energy-operator-for-speech-recognition
#8
Hardik B Sailor, Hemant A Patil
In this letter, authors propose an auditory feature representation technique with the filterbank learned using an annealing dropout convolutional restricted Boltzmann machine (ConvRBM) and noise-robust energy estimation using the Teager energy operator (TEO). TEO is applied on each subband of ConvRBM filterbank and pooled later to get the short-term spectral features. Experiments on AURORA 4 database show that the proposed features perform better than the Mel filterbank features. The relative improvement of 2...
June 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28618001/three-dimensional-cell-culture-models-for-anticancer-drug-screening-worth-the-effort
#9
REVIEW
Eddy-Tim Verjans, Jordi Doijen, Walter Luyten, Bart Landuyt, Liliane Schoofs
High attrition of new oncology drug candidates in clinical trials is partially caused by the poor predictive capacity of artificial monolayer cell culture assays early in drug discovery. Monolayer assays do not take the natural three-dimensional (3D) microenvironment of cells into account. As a result, false positive compounds often enter clinical trials, leading to high dropout rates and a waste of time and money. Over the past two decades, tissue engineers and cell biologists have developed a broad range of 3D in vitro culturing tools that better represent in vivo cell biology...
June 15, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28617731/retention-rates-in-new-contact-lens-wearers
#10
Anna Sulley, Graeme Young, Chris Hunt, Sarah McCready, Marie-Therese Targett, Ruth Craven
PURPOSE: To determine the retention rate (RR) for neophyte patients fitted with contact lenses (CLs) and to identify factors associated with retention and dropout. METHOD: This multisite, sponsor-masked registry study evaluated the 1-year status of neophyte CL wearers fitted in a representative range of UK practices. A total of 26 UK investigational sites each recruited up to 89 neophyte patients. The participants were requested to complete surveys at 1 month (±1 week from date of fitting), 3 months (±2 weeks), and 12 months (±3 weeks) online or through phone...
June 14, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28615923/changes-in-meibomian-gland-morphology-and-ocular-higher-order-aberrations-in-eyes-with-chalazion
#11
Shima Fukuoka, Reiko Arita, Rika Shirakawa, Naoyuki Morishige
PURPOSE: To examine the changes in meibomian gland morphology and ocular higher-order aberrations (HOAs) in eyes with chalazion and its excision. METHODS: Seven male patients with previous history of chalazion excision and seven control male subjects were enrolled. Changes in meibomian gland morphology (meiboscores, gland dropout, and shortening) were evaluated by using meibography equipped in a wavefront analyzer KR-1W and in a slit-lamp device BG-4M. Ocular HOAs were measured sequentially with KR-1W...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28614344/self-starting-dropout-free-harmonic-mode-locked-soliton-fiber-laser-with-a-low-timing-jitter
#12
Qiang Hao, Yunfeng Wang, Peng Luo, Hong Hu, Heping Zeng
We demonstrate a simple, but robust, self-starting environmentally stable passive harmonic mode-locked femtosecond Er-fiber laser with a scalable repetition rate of up to the 10th harmonic and >50  dB of supermode suppression. The repetition rate of short- and long-term operation for each harmonic appears to have no pulse dropout. Furthermore, at as low as 0.8 and 2.1 mHz standard deviation, the repetition rate is achieved by using the pump-induced nonlinearity to modulate the refractive index of the gain fiber...
June 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28609646/why-do-indiviuals-with-schizophrenia-drop-out-of-observational-clinical-trials
#13
Alex Hofer, Verena Radner, Monika Edlinger, Georg Kemmler, Maria A Rettenbacher, W Wolfgang Fleischhacker
Randomized controlled trials (RCTs) and observational studies frequently differ with regard to study dropouts. The present naturalistic follow-up investigation aimed to shed a light on this issue by evaluating the time to and the reasons for study dropout in patients suffering from schizophrenia who started monotherapy with an oral new-generation antipsychotic. To this end, psychopathological symptoms and safety data were assessed in 194 patients who were followed up to a maximum observation period of twelve months...
June 10, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28609148/an-intensive-outpatient-treatment-program-for-combat-related-ptsd-trauma-management-therapy
#14
Deborah C Beidel, Jeremy W Stout, Sandra M Neer, B Christopher Frueh, Carl Lejuez
An estimated 18.5% of veterans returning from Operation Iraqi Freedom, Operation Enduring Freedom, and Operation New Dawn are suffering from posttraumatic stress or posttraumatic stress disorder (PTSD). The number of veterans and service duty personnel requesting VA health care services is increasing, and the VA's ability to handle requests is dwindling. Thus, both the content of interventions and the format by which these services are delivered need to be reconceptualized. The authors present a multicomponent intervention program known as Trauma Management Therapy (TMT), a comprehensive, empirically supported treatment that can be delivered in an intensive, 3-week outpatient format...
2017: Bulletin of the Menninger Clinic
https://www.readbyqxmd.com/read/28605811/parapapillary-deep-layer-microvasculature-dropout-in-glaucoma-topographic-association-with-glaucomatous-damage
#15
Eun Ji Lee, Seung Hyen Lee, Jeong-Ah Kim, Tae-Woo Kim
Purpose: The purpose of this article was to compare the frequencies of the parapapillary deep-layer microvasculature dropout (MvD) detected by optical coherence tomography angiography in eyes with primary open-angle glaucoma (POAG) and healthy eyes and to determine the topographic correlation between the MvD and the glaucomatous retinal nerve fiber layer (RNFL) defect in POAG eyes. Methods: Microvasculature in the peripapillary deep-layer was evaluated in 150 POAG patients and 45 healthy controls using swept-source optical coherence tomography angiography to identify an MvD...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28603829/adherence-to-treatment-with-continuous-positive-airway-pressure-in-the-obstructive-sleep-apnea-syndrome
#16
Ahmed Abdelghani, Wafa Benzarti, Hlima Ben Salem, Imen Gargouri, Abdelhamid Garrouche, Abdelaziz Hayouni, Mohamed Benzarti
INTRODUCTION: Continuous positive airway pressure (CPAP) is the most effective treatment for obstructive sleep apnea (OSA). Adequate compliance with the use of CPAP is cardinal to achieve cardiovascular, metabolic and neuropsychological benefits of treatment. AIM: Assess the factors affecting compliance to the CPAP treatment and analyze the long term acceptance. METHODS: Retrospective study on 130 patients treated by CPAP for OSA in the department of pulmonology between 2005 and 2014...
August 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28602943/in-vivo-b0-field-shimming-methods-for-mri-at-7-t
#17
Jason P Stockmann, Lawrence L Wald
Functional MRI (fMRI) at 7 T and above provides improved Signal-to-Noise Ratio and Contrast-to-Noise Ratio compared to 3 T acquisitions. In addition to the beneficial effects on spin polarization and magnetization of deoxyhemoglobin, the increased applied field also further magnetizes air and tissue. While the magnets themselves typically provide a static B0 field with sufficient spatial homogeneity, the diamagnetism of tissue and the paramagnetism of air causes local field deviations inside the human head...
June 7, 2017: NeuroImage
https://www.readbyqxmd.com/read/28601913/the-effects-of-a-non-cognitive-versus-cognitive-admission-procedure-within-cohorts-in-one-medical-school
#18
Marieke de Visser, Cornelia Fluit, Janke Cohen-Schotanus, Roland Laan
In medical school selection, non-cognitive performance in particular correlates with performance in clinical practice. It is arguable, therefore, that selection should focus on non-cognitive aspects despite the predictive value of prior cognitive performance for early medical school performance. The aim of this study at Radboud University Medical Center, the Netherlands, is to determine the effects of admitting students through an autonomous non-cognitive procedure on early medical school performance. We compared their performance to the performance of students selected through an autonomous cognitive selection procedure, enrolling in the Bachelor's curriculum simultaneously...
June 10, 2017: Advances in Health Sciences Education: Theory and Practice
https://www.readbyqxmd.com/read/28597805/efficacy-of-sequential-three-step-empirical-therapy-for-chronic-cough
#19
Li Yu, Xianghuai Xu, Jingqing Hang, Kewen Cheng, Xiaoyan Jin, Qiang Chen, Hanjing Lv, Zhongmin Qiu
BACKGROUND: Empirical three-step therapy has been proved in just one hospital. This study aimed to demonstrate applicability of the sequential empirical three-step therapy for chronic cough in different clinical settings. METHODS: Sequential empirical three-step therapy was given to patients with chronic cough in one tertiary and three secondary care respiratory clinics. Recruiters were initially treated with methoxyphenamine compound as the first-step therapy, followed by corticosteroids as the second-step therapy and the combination of a proton-pump inhibitor and a prokinetic agent as the third-step therapy...
June 2017: Therapeutic Advances in Respiratory Disease
https://www.readbyqxmd.com/read/28597618/effects-of-resistance-training-overtraining-and-early-specialization-on-youth-athletes
#20
Benjamin K Walters, Connor R Read, A Reed Estes
INTRODUCTION: In 2014, 60 million youth ages 6-18 participated in some form of generalized athletics. 3.5 million children are injured annually participating in organized sport or recreational activities. While sound physical education can decrease the burden of youth sports injuries, the median annual physical education budget of $764 for United States elementary, middle and high schools may not allow enough flexibility to apply evidenced-based guidelines. EVIDENCE ACQUISITION: The topics were selected after a careful review of the 2016 National Strength and Conditioning Association Position Statement on Long-Term Athletic Development...
June 8, 2017: Journal of Sports Medicine and Physical Fitness
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