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https://www.readbyqxmd.com/read/28223262/factors-associated-with-dropout-during-recruitment-and-follow-up-periods-of-a-mhealth-based-randomized-controlled-trial-for-mobile-net-to-encourage-treatment-adherence-for-people-with-serious-mental-health-problems
#1
Kati Anneli Kannisto, Joonas Korhonen, Clive E Adams, Marita Hannele Koivunen, Tero Vahlberg, Maritta Anneli Välimäki
BACKGROUND: Clinical trials are the gold standard of evidence-based practice. Still many papers inadequately report methodology in randomized controlled trials (RCTs), particularly for mHealth interventions for people with serious mental health problems. To ensure robust enough evidence, it is important to understand which study phases are the most vulnerable in the field of mental health care. OBJECTIVE: We mapped the recruitment and the trial follow-up periods of participants to provide a picture of the dropout predictors from a mHealth-based trial...
February 21, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28223187/deepnat-deep-convolutional-neural-network-for-segmenting-neuroanatomy
#2
Christian Wachinger, Martin Reuter, Tassilo Klein
We introduce DeepNAT, a 3D Deep convolutional neural network for the automatic segmentation of NeuroAnaTomy in T1-weighted magnetic resonance images. DeepNAT is an end-to-end learning-based approach to brain segmentation that jointly learns an abstract feature representation and a multi-class classification. We propose a 3D patch-based approach, where we do not only predict the center voxel of the patch but also neighbors, which is formulated as multi-task learning. To address a class imbalance problem, we arrange two networks hierarchically, where the first one separates foreground from background, and the second one identifies 25 brain structures on the foreground...
February 18, 2017: NeuroImage
https://www.readbyqxmd.com/read/28222871/evaluation-of-hypersensitivity-after-the-placement-of-metal-ceramic-crowns-cemented-with-two-luting-agents-long-term-results-of-a-prospective-clinical-study
#3
Carla Kozmacs, Katharina Schaper, Hans-Christoph Lauer, Andree Piwowarczyk
STATEMENT OF PROBLEM: Different luting materials are available for the cementation of fixed dental prostheses. Postcementation hypersensitivity is an occasional complication in the definitive delivery. How the choice of luting agent affects long-term postcementation sensitivity is unknown. PURPOSE: The purpose of this prospective, randomized, controlled, split-mouth clinical trial was to compare the hypersensitivity of 2 cementation methods for metal ceramic crowns...
February 17, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28222778/sample-size-considerations-for-trials-using-cerebral-white-matter-hyperintensity-progression-as-an-intermediate-outcome-at-1%C3%A2-year-after-mild-stroke-results-of-a-prospective-cohort-study
#4
Francesca M Chappell, Maria Del Carmen Valdés Hernández, Stephen D Makin, Kirsten Shuler, Eleni Sakka, Martin S Dennis, Paul A Armitage, Susana Muñoz Maniega, Joanna M Wardlaw
BACKGROUND: White matter hyperintensities (WMHs) are commonly seen on in brain imaging and are associated with stroke and cognitive decline. Therefore, they may provide a relevant intermediate outcome in clinical trials. WMH can be measured as a volume or visually on the Fazekas scale. We investigated predictors of WMH progression and design of efficient studies using WMH volume and Fazekas score as an intermediate outcome. METHODS: We prospectively recruited 264 patients with mild ischaemic stroke and measured WMH volume, Fazekas score, age and cardiovascular risk factors at baseline and 1 year...
February 21, 2017: Trials
https://www.readbyqxmd.com/read/28222360/maintenance-therapy-with-second-generation-antipsychotics-for-bipolar-disorder-a-systematic-review-and-meta-analysis
#5
REVIEW
Leif Lindström, Eva Lindström, Mikael Nilsson, Malin Höistad
BACKGROUND: Second generations antipsychotics (SGA) are frequently used for maintenance treatment in bipolar disorder. We systematically reviewed the efficacy and long-term effects of treatment with SGA, regardless of treatment strategy (SGA administered either as monotherapy or as adjunctive therapy), in comparison to placebo, lithium or valproate. Primary outcomes were relapses (mood episode recurrence) and discontinuation. METHOD: Clinical studies were identified through database searching in PubMed, Embase, PsychInfo and Cochrane Library and critically appraised based on the Cochrane Handbook...
February 14, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28220474/buprenorphine-for-managing-opioid-withdrawal
#6
REVIEW
Linda Gowing, Robert Ali, Jason M White, Dalitso Mbewe
BACKGROUND: Managed withdrawal is a necessary step prior to drug-free treatment or as the endpoint of substitution treatment. OBJECTIVES: To assess the effects of buprenorphine versus tapered doses of methadone, alpha2-adrenergic agonists, symptomatic medications or placebo, or different buprenorphine regimens for managing opioid withdrawal, in terms of the intensity of the withdrawal syndrome experienced, duration and completion of treatment, and adverse effects...
February 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28217880/follow-up-assessment-of-cognitive-remediation-therapy-in-adolescent-anorexia-nervosa-a-pilot-study
#7
Laura Herbrich, Betteke van Noort, Ernst Pfeiffer, Ulrike Lehmkuhl, Sibylle Winter, Viola Kappel
OBJECTIVE: Cognitive remediation therapy (CRT) is a specialized treatment approach targeting cognitive weaknesses in anorexia nervosa (AN). Regarding follow-up effects of CRT, there are only few studies available; for adolescents, there are no data. METHODS: Forty-eight adolescents with AN were assigned to receive either CRT and treatment as usual (TAU) or TAU alone. Assessments were performed at baseline (n = 48) and compared with assessments at a 6-month follow-up (n = 33)...
March 2017: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/28216234/optimal-modified-tracking-performance-for-mimo-networked-control-systems-with-communication-constraints
#8
Jie Wu, Zhu-Jun Zhou, Xi-Sheng Zhan, Huai-Cheng Yan, Ming-Feng Ge
This paper investigates the optimal modified tracking performance of multi-input multi-output (MIMO) networked control systems (NCSs) with packet dropouts and bandwidth constraints. Some explicit expressions are obtained by using co-prime factorization and the spectral decomposition technique. The obtained results show that the optimal modified tracking performance is related to the intrinsic properties of a given plant such as non-minimum phase (NMP) zeros, unstable poles, and their directions. Furthermore, the modified factor, packet dropouts probability and bandwidth also impact the optimal modified tracking performance of the NCSs...
February 16, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28214662/socioeconomic-background-and-high-school-completion-mediation-by-health-and-moderation-by-national-context
#9
Sharon R Sznitman, Liza Reisel, Atika Khurana
This study uses longitudinal data from the Norwegian Health Study linked with registry data (n = 13262) and the U.S. National Longitudinal Survey of Youth 1997 (n = 3604) to examine (1) whether adolescent health mediates the well-established relationship between socioeconomic background and successful high school completion, and (2) whether this mediated pathway of influence varies by national context. Adolescents from lower educated and lower income families reported poorer health, which negatively impacted their likelihood of graduating from high school...
February 16, 2017: Journal of Adolescence
https://www.readbyqxmd.com/read/28213988/-contribution-of-mindfulness-meditation-in-cognitive-behavioral-therapy-for-insomnia
#10
H Vanhuffel, M Rey, I Lambert, D Da Fonseca, F Bat-Pitault
INTRODUCTION: Insomnia is considered to be a serious public health issue affecting approximately 10% of adults. Chronic insomnia may increase the risk of health problem, psychological vulnerability and proneness to accidents. Cognitive behavioral therapy for insomnia (CBT-I) is recommended as the first line of treatment. Even though CBT-I is widely considered as an effective therapy, 20 to 30% of patients do not respond to this treatment. Mindfulness therapy, known to reduce rumination and stress, could be an interesting complement to enhance CBT-I...
February 14, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28212466/withdrawn-propranolol-for-migraine-prophylaxis
#11
REVIEW
Klaus Linde, Karin Rossnagel
BACKGROUND: Propranolol is one of the most commonly prescribed drugs for migraine prophylaxis. OBJECTIVES: We aimed to determine whether there is evidence that propranolol is more effective than placebo and as effective as other drugs for the interval (prophylactic) treatment of patients with migraine. SEARCH METHODS: Potentially eligible studies were identified by searching MEDLINE/PubMed (1966 to May 2003) and the Cochrane Central Register of Controlled Trials (Issue 2, 2003), and by screening bibliographies of reviews and identified articles...
February 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28207771/comparison-of-whole-genome-amplification-techniques-for-human-single-cell-exome-sequencing
#12
Erik Borgström, Marta Paterlini, Jeff E Mold, Jonas Frisen, Joakim Lundeberg
BACKGROUND: Whole genome amplification (WGA) is currently a prerequisite for single cell whole genome or exome sequencing. Depending on the method used the rate of artifact formation, allelic dropout and sequence coverage over the genome may differ significantly. RESULTS: The largest difference between the evaluated protocols was observed when analyzing the target coverage and read depth distribution. These differences also had impact on the downstream variant calling...
2017: PloS One
https://www.readbyqxmd.com/read/28197341/a-mixed-methods-small-pilot-study-to-describe-the-effects-of-upper-limb-training-using-a-virtual-reality-gaming-system-in-people-with-chronic-stroke
#13
Rachel C Stockley, Deborah A O'Connor, Phil Smith, Sylvia Moss, Lizzie Allsop, Wendy Edge
Introduction. This small pilot study aimed to examine the feasibility of an upper limb rehabilitation system (the YouGrabber) in a community rehabilitation centre, qualitatively explore participant experiences, and describe changes after using it. Methods and Material. Chronic stroke participants attending a community rehabilitation centre in the UK were randomised to either a YouGrabber or a gym group and completed 18 training sessions over 12 weeks. The motor activity log, box and block, and fatigue severity score were administered by a blinded assessor before and after the intervention...
2017: Rehabilitation Research and Practice
https://www.readbyqxmd.com/read/28196078/data-driven-system-to-predict-academic-grades-and-dropout
#14
Sergi Rovira, Eloi Puertas, Laura Igual
Nowadays, the role of a tutor is more important than ever to prevent students dropout and improve their academic performance. This work proposes a data-driven system to extract relevant information hidden in the student academic data and, thus, help tutors to offer their pupils a more proactive personal guidance. In particular, our system, based on machine learning techniques, makes predictions of dropout intention and courses grades of students, as well as personalized course recommendations. Moreover, we present different visualizations which help in the interpretation of the results...
2017: PloS One
https://www.readbyqxmd.com/read/28195930/treatment-duration-with-long-acting-injectable-antipsychotics-after-in-hospital-initiation-a-retrospective-cohort-study
#15
Hans Rittmannsberger, Jan Rosenleitner, Gertraud Malsiner-Walli, Regina Werl, Barbara Rittmannsberger, Kurosch Yazdi
PURPOSE: Long-acting injectable (LAI) antipsychotics are recommended especially for patients with multiple admissions and poor adherence. The empirical basis of this strategy is a matter of debate. METHODS: In a retrospective cohort study extending over 6 years, all patients admitted for inpatient treatment with a diagnosis of psychotic disorders according to International Statistical Classification of Diseases and Related Health Problems, 10th Revision (F2) were screened for treatment episodes with a new start of an LAI...
February 13, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28193599/an-online-intervention-comparing-a-very-low-carbohydrate-ketogenic-diet-and-lifestyle-recommendations-versus-a-plate-method-diet-in-overweight-individuals-with-type-2-diabetes-a-randomized-controlled-trial
#16
Laura R Saslow, Ashley E Mason, Sarah Kim, Veronica Goldman, Robert Ploutz-Snyder, Hovig Bayandorian, Jennifer Daubenmier, Frederick M Hecht, Judith T Moskowitz
BACKGROUND: Type 2 diabetes is a prevalent, chronic disease for which diet is an integral aspect of treatment. In our previous trial, we found that recommendations to follow a very low-carbohydrate ketogenic diet and to change lifestyle factors (physical activity, sleep, positive affect, mindfulness) helped overweight people with type 2 diabetes or prediabetes improve glycemic control and lose weight. This was an in-person intervention, which could be a barrier for people without the time, flexibility, transportation, social support, and/or financial resources to attend...
February 13, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28193598/barriers-to-remote-health-interventions-for-type-2-diabetes-a-systematic-review-and-proposed-classification-scheme
#17
Michelle M Alvarado, Hye-Chung Kum, Karla Gonzalez Coronado, Margaret J Foster, Pearl Ortega, Mark A Lawley
BACKGROUND: Diabetes self-management involves adherence to healthy daily habits typically involving blood glucose monitoring, medication, exercise, and diet. To support self-management, some providers have begun testing remote interventions for monitoring and assisting patients between clinic visits. Although some studies have shown success, there are barriers to widespread adoption. OBJECTIVE: The objective of our study was to identify and classify barriers to adoption of remote health for management of type 2 diabetes...
February 13, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28188502/efficacy-of-preoperative-portal-vein-embolization-among-patients-with-hepatocellular-carcinoma-biliary-tract-cancer-and-colorectal-liver-metastases-a-comparative-study-based-on-single-center-experience-of-319-cases
#18
Suguru Yamashita, Yoshihiro Sakamoto, Satoshi Yamamoto, Nobuyuki Takemura, Kiyohiko Omichi, Hiroji Shinkawa, Kazuhiro Mori, Junichi Kaneko, Nobuhisa Akamatsu, Junichi Arita, Kiyoshi Hasegawa, Norihiro Kokudo
BACKGROUND: Efficacy of preoperative portal vein embolization (PVE) has been established; however, differences of outcomes among diseases, including hepatocellular carcinoma (HCC), biliary tract cancer (BTC), and colorectal liver metastases (CLM), are unclear. METHODS: Subjects included patients in a prospectively collected database undergoing PVE (from 1995 to 2013). A future liver remnant (FLR) volume ≥40% is the minimal requirement for patients with an indocyanine green retention rate at 15 min (ICGR15) <10%, and stricter criteria (FLR volume ≥50%) have been applied for patients with 20% > ICGR15 ≥ 10%...
February 10, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28185086/web-based-information-and-support-for-patients-with-a-newly-diagnosed-neuroendocrine-tumor-a-feasibility-study
#19
Grietje Bouma, Lotte D de Hosson, Claudia E van Woerkom, Hennie van Essen, Geertruida H de Bock, Jolien M Admiraal, Anna K L Reyners, Annemiek M E Walenkamp
PURPOSE: Patients with a neuroendocrine tumor (NET) frequently experience physical and psychosocial complaints. Novel strategies to provide information to optimize supportive care in these patients are of interest. The aim of this study was to examine whether the use of a web-based system consisting of self-screening of problems and care needs, patient education, and self-referral to professional health care is feasible in NET patients and to evaluate their opinion on this. METHODS: Newly diagnosed NET patients were randomized between standard care (n = 10) or intervention with additional access to the web-based system (n = 10) during 12 weeks...
February 9, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28183399/efficacy-of-a-randomized-controlled-self-regulation-based-physical-activity-intervention-for-chronic-fatigue-mediation-effects-of-physical-activity-progress-and-self-regulation-skills
#20
M M Marques, V de Gucht, I Leal, S Maes
OBJECTIVE: Examine the medium-term effects of a brief physical activity (PA) self-regulation (SR) based intervention (4-STEPS program) for chronic fatigue, and explore the mediating effects of PA related variables and SR skills. METHODS: A two-arm randomized controlled trial (Usual Care vs 4-STEPS) was carried out. The 4-STEPS program consisted of Motivational Interviewing and SR-skills training. Fatigue severity (primary outcome) and impact, PA, health-related quality of life (HrQoL), and somatic and psychological distress were assessed at baseline, post-treatment (12weeks) and 12months follow-up...
March 2017: Journal of Psychosomatic Research
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