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https://www.readbyqxmd.com/read/29145357/global-routine-vaccination-coverage-2016
#1
Leora R Feldstein, Stephanie Mariat, Marta Gacic-Dobo, Mamadou S Diallo, Laura M Conklin, Aaron S Wallace
The Global Vaccine Action Plan 2011-2020 (GVAP) (1), endorsed by the World Health Assembly in 2012, calls on all countries to reach ≥90% national coverage for all vaccines in the country's routine immunization schedule by 2020. CDC and the World Health Organization (WHO) evaluated the WHO and United Nations Children's Fund (UNICEF) global vaccination coverage estimates to describe changes in global and regional coverage as of 2016. Global coverage estimates for the third dose of diphtheria and tetanus toxoids and pertussis-containing vaccine (DTP3), the third dose of polio vaccine, and the first dose of measles-containing vaccine (MCV1) have ranged from 84% to 86% since 2010...
November 17, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29144536/isolation-and-whole-genome-sequencing-of-fetal-cells-from-maternal-blood-towards-the-ultimate-non-invasive-prenatal-testing
#2
Fang Chen, Ping Liu, Ying Gu, Zhu Zhu, Amulya Nanisetti, Zhangzhang Lan, Zhiwei Huang, Sophie Jia Liu, Xiongbin Kang, Yuqing Deng, Liqiong Luo, Dan Jiang, Yong Qiu, Jianchang Pan, Jun Xia, Ken Xiong, Chao Liu, Lin Xie, Qianyu Shi, Jing Li, Xiuqing Zhang, Wei Wang, Snezana Drmanac, Hui Jiang, Radoje Drmanac, Xun Xu
OBJECTIVE: To develop a methodology of isolating fetal cells from maternal blood and use deep sequencing demonstrating the promise for more complete and accurate genetic screening compared to other non-invasive prenatal testing (NIPT). METHODS: Here in this study, we developed a double negative selection (DNS) procedure to unbiasedly enrich fetal cells. After validated by short tandem repeat (STR), the isolated CFCs were subjected to deep whole genome sequencing analysis (WGS)...
November 16, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29143169/predictors-and-patterns-of-psychiatric-treatment-dropout-during-pregnancy-among-low-income-women
#3
Sara L Kornfield, Christina D Kang-Yi, David S Mandell, C Neill Epperson
Objective This study compared psychiatric treatment discontinuation rates among pregnant women using psychotropic medications, outpatient psychotherapy, or both before conception. Methods Using data from Pennsylvania Medicaid Fee-For-Service and Managed Care Organization claims and Medicaid enrollment, 3030 women were identified who gave birth between 2007 and 2009, had ≥ 1 claim for psychiatric treatment during the 120 days prior to pregnancy, and were enrolled in Medicaid until they delivered. Kaplan-Meier and Cox regression analyses were used to estimate psychiatric treatment dropout rate during pregnancy and examine relationships between treatment dropout and age, race/ethnicity, and pre-pregnancy psychiatric diagnosis and treatment pattern...
November 15, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29141546/current-theories-and-clinical-trial-evidence-for-limiting-human-abdominal-aortic-aneurysm-growth
#4
Jing Yu, Shuai Liu, Jianhua Huang, Wei Wang
BACKGROUND: Abdominal aortic aneurysm (AAA) refers to localized dilation of abdominal aorta. AAA is largely asymptomatic, but aneurysmal rupture results in a high mortality rate. AAA with a diameter greater than 55 mm carries a high risk of rupture. There are currently no known medical treatments effective in limiting the growth of small AAA. OBJECTIVE: To review the current status of and challenges faced in limiting AAA growth. METHODS: Data from human investigations and animal model studies were summarized...
November 12, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/29138977/-reasons-for-delayed-and-discontinued-therapy-in-age-related-macular-degeneration
#5
M W M Wintergerst, J Bouws, J Loss, B Heimes, D Pauleikhoff, F G Holz, R P Finger
BACKGROUND: Critical prerequisites for successful therapy of neovascular age-related macular degeneration (nvAMD) are an early initiation and continuous monitoring; however, delays in starting therapy and non-medically indicated discontinuation of therapy are frequent, which limits therapy efficacy and, thus, visual outcomes. OBJECTIVE: To identify the reasons for delay in therapy and non-medically indicated termination of therapy. MATERIAL AND METHODS: Patients who had started a new therapy (starters) and those who independently terminated therapy (dropouts) were interviewed by telephone with a specific, standardized questionnaire...
November 14, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29138647/nodding-syndrome-ns-and-onchocerca-volvulus-ov-in-northern-uganda
#6
David Kitara Lagoro, Denis Anywar Arony
Nodding Syndrome (NS) is a childhood neurological disorder characterized by atonic seizures, cognitive decline, school dropout, muscle weakness, thermal dysfunction, wasting and stunted growth. There are recent published information suggesting associations between Nodding Syndrome (NS) with cerebrospinal fluid (CSF) VGKC antibodies and serum leiomidin-1 antibody cross reacting with Onchocerca Volvulus (OV). These findings suggest a neuro-inflammatory cause of NS and they are important findings in the search for the cause of Nodding Syndrome...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29137019/optical-coherence-tomography-angiography-in-patients-with-diabetic-retinopathy-treated-with-anti-vegf-intravitreal-injections-case-report
#7
Katarzyna Michalska-Małecka, Anna Heinke Knudsen
PURPOSE: To present optical coherence tomography angiography (OCTA) features in patients with diabetic retinopathy (DR) at the baseline and in response to treatment with anti-VEGF intravitreal injections. To investigate the role of OCTA in management of patients with DR. METHODS: Retrospective case series showing primary outcomes of 3 patients with DR and diabetic macular edema. Patients were injected intravitreally a loading phase of 3 monthly 2.0 mg aflibercept, followed by 2 injections bimonthly (5 injections in total)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29136445/effect-of-varying-doses-of-epicutaneous-immunotherapy-vs-placebo-on-reaction-to-peanut-protein-exposure-among-patients-with-peanut-sensitivity-a-randomized-clinical-trial
#8
Hugh A Sampson, Wayne G Shreffler, William H Yang, Gordon L Sussman, Terri F Brown-Whitehorn, Kari C Nadeau, Amarjit S Cheema, Stephanie A Leonard, Jacqueline A Pongracic, Christine Sauvage-Delebarre, Amal H Assa'ad, Frederic de Blay, J Andrew Bird, Stephen A Tilles, Franck Boralevi, Thierry Bourrier, Jacques Hébert, Todd D Green, Roy Gerth van Wijk, André C Knulst, Gisèle Kanny, Lynda C Schneider, Marek L Kowalski, Christophe Dupont
Importance: Epicutaneous immunotherapy may have potential for treating peanut allergy but has been assessed only in preclinical and early human trials. Objective: To determine the optimal dose, adverse events (AEs), and efficacy of a peanut patch for peanut allergy treatment. Design, Setting, and Participants: Phase 2b double-blind, placebo-controlled, dose-ranging trial of a peanut patch in peanut-allergic patients (6-55 years) from 22 centers, with a 2-year, open-label extension (July 31, 2012-July 31, 2014; extension completed September 29, 2016)...
November 14, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29132280/mixed-results-the-protective-role-of-schooling-in-the-hiv-epidemic-in-swaziland
#9
Alan Whiteside, Andriana Vinnitchok, Tengetile Dlamini, Khanya Mabuza
Swaziland has the highest HIV prevalence in the world. It is recognised that young women, especially adolescents, are particularly vulnerable to HIV infection and bear a disproportionate burden of HIV incidence. The HIV data from Swaziland show the location of the epidemic, which is particularly high among adolescent girls and young women. This paper is based on research in Swaziland, commissioned because of the perception that large numbers of children were dropping out of the school. It was assumed that these "dropouts" had increased risk of HIV exposure...
December 2017: African Journal of AIDS Research: AJAR
https://www.readbyqxmd.com/read/29131738/experiences-of-women-who-participated-in-a-beta-test-for-an-online-streamed-yoga-intervention-after-a-stillbirth
#10
Jennifer L Huberty, Jeni Matthews, Jenn Leiferman, Joanne Cacciatore
BACKGROUND: Little is known about how to best care for mothers after stillbirth. As such, this paper will report the satisfaction and perceptions of an online yoga intervention (12-week beta test) in women after stillbirth. METHODS: Participants (n=74) had a stillbirth within the last 24-months (M time since loss 9.65 ± 6.9 months). Post-intervention satisfaction surveys and interviews and dropout surveys were conducted. Descriptive statistics were used to analyze survey responses and demographic information...
November 2017: International Journal of Yoga Therapy
https://www.readbyqxmd.com/read/29129887/-analysis-of-backgrounds-and-level-of-understanding-of-treatment-of-poor-adherence-and-dropout-cases-on-sublingual-immunotherapy-for-japanese-cedar-pollinosis-in-the-first-follow-up-year
#11
Sayaka Kikkawa, Atsushi Kamijo, Kazuyuki Nakagome, Tomoyuki Soma, Takehito Kobayashi, Yoshitaka Uchida, Eiji Morita, Makoto Nagata, Tomoe Inoue, Yasuhiro Kase
BACKGROUND: We considered the factors of poor adherence to and dropout from sublingual immunotherapy (SLIT) by verifying patient backgrounds 1 year after start of treatment. METHODS: We recruited 38 patients who began SLIT between November 2014 and September 2015. We analyzed their attributes and level of understanding of the treatment, and conducted a self-reported survey on factors behind dropout cases and poor adherence cases. RESULTS: Four patients dropped out 1 year after start of treatment...
2017: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/29128195/-what-support-of-young-presenting-a-first-psychotic-episode-when-schooling-is-being-challenged
#12
M-N Vacheron, H Veyrat-Masson, E Wehbe
Psychiatric disorders (more specifically mood disorders and psychosis) represent the 1st cause of disability among young people. Unemployment rate between 75 to 95% for the person with schizophrenia. It is correlated to poor social integration and bad economic status, worse symptomatology loss of autonomy as well as global bad functioning. It is responsible of more than half of the overall cost of psychosis. The onset of most of psychiatric disorders occur between the age of 25 and 35 years old, a critical time in young adult life when they should build their professional as well as social future...
November 8, 2017: L'Encéphale
https://www.readbyqxmd.com/read/29126193/the-early-onset-of-distress-disorders-and-high-school-dropout-prospective-evidence-from-a-national-cohort-of-australian-adolescents
#13
Peter Butterworth, Liana S Leach
Prior research examining whether depression and anxiety lead to high school dropout is limited by a reliance on retrospective reports, the assessment of mental health at a single point in time (often remote from the time of high school exit) and omission of important measures of the social and familial environment. The current study addresses these limitations by analyzsing 8 waves of longitudinal data from a cohort of Australian adolescents (n = 1,057) in the Household Income and Labor Dynamics in Australia (HILDA) Survey (2001-2008)...
November 8, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29126070/deep-neural-networks-for-texture-classification-a-theoretical-analysis
#14
Saikat Basu, Supratik Mukhopadhyay, Manohar Karki, Robert DiBiano, Sangram Ganguly, Ramakrishna Nemani, Shreekant Gayaka
We investigate the use of Deep Neural Networks for the classification of image datasets where texture features are important for generating class-conditional discriminative representations. To this end, we first derive the size of the feature space for some standard textural features extracted from the input dataset and then use the theory of Vapnik-Chervonenkis dimension to show that hand-crafted feature extraction creates low-dimensional representations which help in reducing the overall excess error rate...
October 23, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/29125964/null-alleles-and-sequence-variations-at-primer-binding-sites-of-str-loci-within-multiplex-typing-systems
#15
Yining Yao, Qinrui Yang, Chengchen Shao, Baonian Liu, Yuxiang Zhou, Hongmei Xu, Yueqin Zhou, Qiqun Tang, Jianhui Xie
Rare variants are widely observed in human genome and sequence variations at primer binding sites might impair the process of PCR amplification resulting in dropouts of alleles, named as null alleles. In this study, 5 cases from routine paternity testing using PowerPlex(®)21 System for STR genotyping were considered to harbor null alleles at TH01, FGA, D5S818, D8S1179, and D16S539, respectively. The dropout of alleles was confirmed by using alternative commercial kits AGCU Expressmarker 22 PCR amplification kit and AmpFℓSTR(®)...
October 28, 2017: Legal Medicine
https://www.readbyqxmd.com/read/29124500/internet-based-self-help-intervention-for-icd-11-adjustment-disorder-preliminary-findings
#16
Jonas Eimontas, Zivile Rimsaite, Goda Gegieckaite, Paulina Zelviene, Evaldas Kazlauskas
Adjustment disorder is one of the most diagnosed mental disorders. However, there is a lack of studies of specialized internet-based psychosocial interventions for adjustment disorder. We aimed to analyze the outcomes of an internet-based unguided self-help psychosocial intervention BADI for adjustment disorder in a two armed randomized controlled trial with a waiting list control group. In total 284 adult participants were randomized in this study. We measured adjustment disorder as a primary outcome, and psychological well-being as a secondary outcome at pre-intervention (T1) and one month after the intervention (T2)...
November 10, 2017: Psychiatric Quarterly
https://www.readbyqxmd.com/read/29124457/when-does-premature-treatment-termination-occur-examining-session-by-session-dropout-among-clients-with-gambling-disorder
#17
Rory A Pfund, Samuel C Peter, James P Whelan, Andrew W Meyers
Premature termination challenges the successful outcomes of psychological treatments for gambling disorder. To date, research has primarily identified clients who are at particular risk for dropping out of treatment. A smaller but growing body of literature has investigated when dropout occurs. Typically, those studies have not considered improvement in psychological distress within their operationalizations of dropout and therefore may have misrepresented when dropout occurs. The current study examined when dropout occurs using an operationalization based on the criteria of attaining reliable change in a naturalistic sample of clients with gambling disorder, and the classification rates yielded from that operationalization were compared to the rates from a more common operationalization...
November 9, 2017: Journal of Gambling Studies
https://www.readbyqxmd.com/read/29121974/a-randomised-double-blind-placebo-controlled-trial-of-minocycline-and-or-omega-3-fatty-acids-added-to-treatment-as-usual-for-at-risk-mental-states-nayab-study-protocol
#18
Inti Qurashi, Imran B Chaudhry, Ameer B Khoso, Sana Farooque, Steve Lane, Mohammad Omair Husain, Simon Chu, Jane Sarginson, Munir Hamarani, Haider A Naqvi, Bushra Razzaque, Fareed A Minhas, Alison R Yung, J F W Deakin, Nusrat Husain
BACKGROUND: The at-risk mental state (ARMS) describes individuals at high risk of developing schizophrenia or psychosis. The use of antipsychotics in this population is not supported, because most individuals with ARMS are unlikely to develop psychosis. Anti-inflammatory treatments and polyunsaturated fatty acids (PUFAs) may have some beneficial effects in the treatment of ARMS. There have been no controlled clinical trials in which researchers have investigated the use of minocycline for ARMS and no trials involving PUFAs in combination with other proposed treatments...
November 9, 2017: Trials
https://www.readbyqxmd.com/read/29117267/the-impact-of-cannabis-use-on-patients-enrolled-in-opioid-agonist-therapy-in-ontario-canada
#19
Alexandra M Franklyn, Joseph K Eibl, Graham J Gauthier, David C Marsh
BACKGROUND: With the Canadian government legalizing cannabis in the year 2018, the potential harms to certain populations-including those with opioid use disorder-must be investigated. Cannabis is one of the most commonly used substances by patients who are engaged in medication-assisted treatment for opioid use disorder, the effects of which are largely unknown. In this study, we examine the impact of baseline and ongoing cannabis use, and whether these are impacted differentially by gender...
2017: PloS One
https://www.readbyqxmd.com/read/29114733/sodium-oxybate-for-excessive-daytime-sleepiness-and-sleep-disturbance-in-parkinson-disease-a-randomized-clinical-trial
#20
Fabian Büchele, Marc Hackius, Sebastian R Schreglmann, Wolfgang Omlor, Esther Werth, Angelina Maric, Lukas L Imbach, Stefan Hägele-Link, Daniel Waldvogel, Christian R Baumann
Importance: Sleep-wake disorders are a common and debilitating nonmotor manifestation of Parkinson disease (PD), but treatment options are scarce. Objective: To determine whether nocturnal administration of sodium oxybate, a first-line treatment in narcolepsy, is effective and safe for excessive daytime sleepiness (EDS) and disturbed nighttime sleep in patients with PD. Design, Setting, and Participants: Randomized, double-blind, placebo-controlled, crossover phase 2a study carried out between January 9, 2015, and February 24, 2017...
November 6, 2017: JAMA Neurology
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