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https://www.readbyqxmd.com/read/29333880/pharmacogenetic-analysis-of-opioid-dependence-treatment-dose-and-dropout-rate
#1
Richard C Crist, James Li, Glenn A Doyle, Alex Gilbert, Bryan M Dechairo, Wade H Berrettini
BACKGROUND: Currently, no pharmacogenetic tests for selecting an opioid-dependence pharmacotherapy have been approved by the US Food and Drug Administration. OBJECTIVES: Determine the effects of variants in 11 genes on dropout rate and dose in patients receiving methadone or buprenorphine/naloxone (ClinicalTrials.gov Identifier: NCT00315341). METHODS: Variants in six pharmacokinetic genes (CYP1A2, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A4) and five pharmacodynamic genes (HTR2A, OPRM1, ADRA2A, COMT, SLC6A4) were genotyped in samples from a 24-week, randomized, open-label trial of methadone and buprenorphine/naloxone for the treatment of opioid dependence (n = 764; 68...
January 15, 2018: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/29333672/controlled-pattern-imputation-for-sensitivity-analysis-of-longitudinal-binary-and-ordinal-outcomes-with-nonignorable-dropout
#2
Yongqiang Tang
The controlled imputation method refers to a class of pattern mixture models that have been commonly used as sensitivity analyses of longitudinal clinical trials with nonignorable dropout in recent years. These pattern mixture models assume that participants in the experimental arm after dropout have similar response profiles to the control participants or have worse outcomes than otherwise similar participants who remain on the experimental treatment. In spite of its popularity, the controlled imputation has not been formally developed for longitudinal binary and ordinal outcomes partially due to the lack of a natural multivariate distribution for such endpoints...
January 15, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/29329371/alcohol-use-in-adolescence-and-later-working-memory-findings-from-a-large-population-based-birth-cohort
#3
Liam Mahedy, Matt Field, Suzanne Gage, Gemma Hammerton, Jon Heron, Matt Hickman, Marcus R Munafò
Aims: The study aimed to examine the association between adolescent alcohol use and working memory (WM) using a large population sample. Methods: Data from the Avon Longitudinal Study of Parents and Children were used to investigate the association between alcohol use at age 15 years and WM 3 years later, assessed using the N-back task (N ~ 3300). A three-category ordinal variable captured mutually exclusive alcohol groupings ranging in order of severity (i.e. low alcohol users, frequent drinkers and frequent/binge drinkers)...
January 10, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29318267/participation-and-dropout-in-the-bundled-payments-for-care-improvement-initiative
#4
Karen E Joynt Maddox, E John Orav, Jie Zheng, Arnold M Epstein
No abstract text is available yet for this article.
January 9, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29316314/an-integrated-tool-for-microsatellite-isolation-and-validation-from-the-reference-genome-and-their-application-in-the-study-of-breeding-turnover-in-an-endangered-avian-population
#5
Xian Hou, Pengwei Xu, Zhenzhen Lin, Josephine d'URBAN-Jackson, Andrew Dixon, Batbayar Bold, Jiliang Xu, Xiangjiang Zhan
Accurate individual identification is required to estimate survival rates in avian populations. For endangered species, non-invasive methods of obtaining individual identification, such as using molted feathers as a source of DNA for microsatellite markers, are preferred because of less disturbance, easy sample preparation and high efficiency. With the availability of many avian genomes, a few pipelines isolating genome-wide microsatellites have been published, but it is still a challenge to isolate microsatellites from the reference genome efficiently...
January 9, 2018: Integrative Zoology
https://www.readbyqxmd.com/read/29313167/prenatal-exposure-to-chernobyl-fallout-in-norway-neurological-and-developmental-outcomes-in-a-25-year-follow-up
#6
Rolv Terje Lie, Dag Moster, Per Strand, Allen James Wilcox
Ionizing radiation at high doses early in life may cause neurodevelopmental problems. Possible effects of lower doses are, however, controversial. We use carefully collected exposure data for Norway following the Chernobyl accident in April 1986 combined with population-based registries to assess long-term effects of fetal exposure on neurodevelopmental outcomes. Radiation doses were estimated for each Norwegian municipality for each calendar month from May 1986 to April 1989. We established a cohort of all Norwegian pregnancies during the three-year period of radiation measurement and compared them with appropriate unexposed groups...
December 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29304100/social-determinants-of-pulmonary-tuberculosis-treatment-non-adherence-in-rio-de-janeiro-brazil
#7
Elvira Maria Godinho de Seixas Maciel, Juliana de Souza Amancio, Daniel Barros de Castro, José Ueleres Braga
Success in tuberculosis control depends on the implementation of steps that reduce social inequities, allowing the diagnosis and effective treatment of the disease. Little is known about the conditions affecting antituberculosis treatment non-adherence in areas of great social and economic heterogeneity, such as the municipality of Rio de Janeiro. This study aimed to describe and identify the social determinants of antituberculosis treatment non-adherence in the municipality of Rio de Janeiro between 2008 and 2012...
2018: PloS One
https://www.readbyqxmd.com/read/29300248/fluorescein-angiographic-evaluation-of-peripheral-retinal-vasculature-after-primary-intravitreal-ranibizumab-for-retinopathy-of-prematurity
#8
C Armitage Harper, Lauren M Wright, Ryan C Young, Sarah P Read, Emmanuel Y Chang
PURPOSE: To evaluate angiographic findings in neonates up to 150 weeks postmenstrual age who received intravitreal ranibizumab for primary treatment of Type 1 retinopathy of prematurity. METHODS: Retrospective evaluation of fluorescein angiogram findings was completed for 30 eyes of 16 neonates who received intravitreal ranibizumab as primary treatment for Type 1 retinopathy of prematurity between April 2013 and January 2015. Outcome measures included maturity to Zone III, vascular blunting, vascular loops, vascular dilatation, capillary dropout, and vascular fluorescein leakage...
January 3, 2018: Retina
https://www.readbyqxmd.com/read/29297299/a-sparse-autoencoder-based-deep-neural-network-for-protein-solvent-accessibility-and-contact-number-prediction
#9
Lei Deng, Chao Fan, Zhiwen Zeng
BACKGROUND: Direct prediction of the three-dimensional (3D) structures of proteins from one-dimensional (1D) sequences is a challenging problem. Significant structural characteristics such as solvent accessibility and contact number are essential for deriving restrains in modeling protein folding and protein 3D structure. Thus, accurately predicting these features is a critical step for 3D protein structure building. RESULTS: In this study, we present DeepSacon, a computational method that can effectively predict protein solvent accessibility and contact number by using a deep neural network, which is built based on stacked autoencoder and a dropout method...
December 28, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29297205/cyclophosphamide-for-connective-tissue-disease-associated-interstitial-lung-disease
#10
REVIEW
Hayley Barnes, Anne E Holland, Glen P Westall, Nicole Sl Goh, Ian N Glaspole
BACKGROUND: Approximately one-third of individuals with interstitial lung disease (ILD) have associated connective tissue disease (CTD). The connective tissue disorders most commonly associated with ILD include scleroderma/systemic sclerosis (SSc), rheumatoid arthritis, polymyositis/dermatomyositis, and Sjögren's syndrome. Although many people with CTD-ILD do not develop progressive lung disease, a significant proportion do progress, leading to reduced physical function, decreased quality of life, and death...
January 3, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29294731/therapeutic-change-in-group-therapy-for-interpersonal-trauma-a-relational-framework-for-research-and-clinical-practice
#11
Zoë Chouliara, Thanos Karatzias, Angela Gullone, Sandra Ferguson, Katie Cosgrove, Claire Burke Draucker
Our understanding of therapeutic change processes in group therapy for complex interpersonal trauma has been limited. The present study aimed at addressing this gap by developing a framework of therapeutic change in this field from a survivor and therapist perspective. This is a qualitative study, which utilized semistructured individual interviews. Transcripts were analyzed using interpretative phenomenological analysis (IPA) to identify recurrent themes. A final sample of n = 16 patients and n = 5 facilitators completed the interview...
April 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29294698/more-likely-to-dropout-but-what-if-they-don-t-partner-violence-offenders-with-alcohol-abuse-problems-completing-batterer-intervention-programs
#12
Marisol Lila, Enrique Gracia, Alba Catalá-Miñana
There is general consensus that alcohol abuse is a risk factor to be considered in batterer intervention programs. Intimate partner violence perpetrators with alcohol abuse problems are more likely to dropout of batterer intervention programs. However, there is little research on intimate partner violence perpetrators with alcohol abuse problems completing batterer intervention programs. In this study, we analyze drop-out rates among perpetrators with alcohol abuse problems and explore whether perpetrators with alcohol abuse problems completing a batterer intervention program differ from those who do not have alcohol abuse problems in a number of outcomes...
March 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29289968/screening-for-maternal-postpartum-depression-and-associationswith-personality-traits-and-social-support-a-polish-follow-upstudy-4-weeks-and-3-months-after-delivery
#13
Karolina Maliszewska, Małgorzata Świątkowska-Freund, Mariola Bidzan, Preis Krzysztof
OBJECTIVES: To investigate the likelihood of postpartum depression and to explore maternal characteristics in terms of personality, social support and other medical and psychological data. METHODS: A sample of 548 patients was investigated 4 weeks and 3 months after delivery. They responded to questionnaires containing sociodemographic questions: the EPDS (Edinburgh Postnatal Depression Scale), the PHQ-9 (Patient Health Questionnaire-9), theNEO-FFI (Personality Inventory), and the BSSS (Berlin Social Support Scales)...
October 29, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/29286534/fitness-training-for-cardiorespiratory-conditioning-after-traumatic-brain-injury
#14
REVIEW
Leanne Hassett, Anne M Moseley, Alison R Harmer
BACKGROUND: Reduced cardiorespiratory fitness (cardiorespiratory deconditioning) is a common consequence of traumatic brain injury (TBI). Fitness training may be implemented to address this impairment. OBJECTIVES: The primary objective of this updated review was to evaluate whether fitness training improves cardiorespiratory fitness in people who have sustained a TBI. The secondary objectives were to evaluate whether fitness training improves body function and structure (physical and cognitive impairments, psychological responses resulting from the injury), activity limitations and participation restrictions in people who have sustained a TBI as well as to evaluate its safety, acceptance, feasibility and suitability...
December 29, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29282507/recovery-of-voice-after-reconstruction-of-the-recurrent-laryngeal-nerve-and-adjuvant-nimodipine
#15
P Mattsson, A Frostell, G Björck, J K E Persson, R Hakim, J Zedenius, M Svensson
BACKGROUND: Transection injury to the recurrent laryngeal nerve (RLN) has been associated with permanent vocal fold palsy, and treatment has been limited to voice therapy or local treatment of vocal folds. Microsurgical repair has been reported to induce a better function. The calcium channel antagonist nimodipine improves functional recovery after experimental nerve injury and also after cranial nerve injury in patients. This study aims to present voice outcome in patients who underwent repair of the RLN and received nimodipine during regeneration...
December 28, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29282271/circulating-tumour-cells-as-a-potential-screening-tool-for-lung-cancer-the-air-study-protocol-of-a-prospective-multicentre-cohort-study-in-france
#16
Sylvie Leroy, Jonathan Benzaquen, Andrea Mazzetta, Sylvain Marchand-Adam, Bernard Padovani, Dominique Israel-Biet, Christophe Pison, Pascal Chanez, Jacques Cadranel, Julien Mazières, Vincent Jounieaux, Charlotte Cohen, Véronique Hofman, Marius Ilie, Paul Hofman, Charles Hugo Marquette
INTRODUCTION: Lung cancer (LC) is the leading cause of death from cancer. Early diagnosis of LC is of paramount importance in terms of prognosis. The health authorities of most countries do not accept screening programmes based on low-dose chest CT (LDCT), especially in Europe, because they are flawed by a high rate of false-positive results, leading to a large number of invasive diagnostic procedures. These authorities advocated further research, including companion biological tests that could enhance the effectiveness of LC screening...
December 26, 2017: BMJ Open
https://www.readbyqxmd.com/read/29280108/csf-inflammatory-markers-and-neurocognitive-function-after-addition-of-maraviroc-to-monotherapy-darunavir-ritonavir-in-stable-hiv-patients-the-cinammon-study
#17
T J Barber, A Imaz, M Boffito, J Niubó, A Pozniak, R Fortuny, J Alonso, N Davies, S Mandalia, D Podzamczer, B Gazzard
CINAMMON is a phase IV, open-label, single-arm, pilot study assessing maraviroc (MVC) in the central nervous system (CNS) when added to darunavir/ritonavir monotherapy (DRV/r) in virologically suppressed HIV-infected subjects. CCR5 tropic participants on DRV/r were recruited. Participants remained on DRV/r for 12 week (w) (control phase). MVC 150 mg qd was added w12-w36 (intervention phase). Lumbar puncture (LP) and neurocognitive function (Cogstate) examinations scheduled at baseline, w12 and w36; MRI before w12, again at w36...
December 26, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/29277843/accommodating-informative-dropout-and-death-a-joint-modelling-approach-for-longitudinal-and-semi-competing-risks-data
#18
Qiuju Li, Li Su
Both dropout and death can truncate observation of a longitudinal outcome. Since extrapolation beyond death is often not appropriate, it is desirable to obtain the longitudinal outcome profile of a population given being alive. We propose a new likelihood-based approach to accommodating informative dropout and death by jointly modelling the longitudinal outcome and semi-competing event times of dropout and death, with an important feature that the conditional longitudinal profile of being alive can be conveniently obtained in a closed form...
January 2018: Journal of the Royal Statistical Society. Series A, (Statistics in Society)
https://www.readbyqxmd.com/read/29276460/management-of-chronic-lateral-epicondylitis-with-manual-therapy-and-local-cryostimulation-a-pilot-study
#19
Nadia Richer, Andrée-Anne Marchand, Martin Descarreaux
Objective: The purpose of this pilot study was to evaluate the feasibility and efficacy of adding cryostimulation to manual therapy in patients with chronic lateral epicondylitis. Methods: The control group (n = 19) was treated with manual therapy consisting of soft-tissue therapy and radial head mobilizations. The experimental group (n = 18) received cryostimulation in addition to manual therapy care similar to that for the control group. Both protocols consisted of 8 treatments over a 4-week period...
December 2017: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/29276430/young-adults-reasons-for-dropout-from-residential-substance-use-disorder-treatment
#20
Kristoffer Nordheim, Espen Walderhaug, Ståle Alstadius, Ann Kern-Godal, Espen Arnevik, Fanny Duckert
Dropout from substance use disorder treatment is usually investigated and understood from a perspective of quantitative patient-related factors. Patients' own perspectives (user perspective) are rarely reported. This study, therefore, aimed to explore patients' own understanding of their dropout from residential substance use disorder treatment. The participants were 15 males and females, aged 19-29 years, who had dropped out of residential substance use disorder treatment at the Department of Addiction Treatment, Oslo University Hospital, Norway...
January 2018: Qualitative Social Work: QSW: Research and Practice
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