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Hepatitis B management

Daniel J Ruzicka, Kentaro Imai, Kenichi Takahashi, Toshio Naito
OBJECTIVES: To investigate the prevalence of chronic comorbidities and the use of comedications in people living with HIV (PLWH) and on antiretrovirals in Japan, by using a hospital claims database. DESIGN: Observational, retrospective, cross-sectional study. SETTING: A hospital claims database of Japanese hospitals that have advanced medical treatment capabilities (ie, advanced treatment hospitals, general hospitals, acute care hospitals), which include those providing acute and chronic care (excluding nursing homes or hospices)...
June 14, 2018: BMJ Open
Heather Schoonover, Kristin Haydon
When breaches in infection control occur, it is imperative that organizations respond in a manner that is effective, efficient, and rebuilds trust with patients. Readers will learn how the incident command structure, daily management system, and the Centers for Disease Control and Prevention's Patient Notification Toolkit were used to drive an effective response to an infection control breach-resulting in 92% of affected patients completing the recommended testing for hepatitis B, hepatitis C, and human immunodeficiency virus...
June 14, 2018: Journal of Healthcare Risk Management: the Journal of the American Society for Healthcare Risk Management
Nam Hoon Moon, Won Chul Shin, Min Uk Do, Hyung Joon Cho, Kuen Tak Suh
The long-term use of adefovir and tenofovir-antiviral medications commonly used to treat chronic hepatitis B-can be associated with proximal renal tubular dysfunction resulting in significant hypophosphatemic osteomalacia. However, there have been few reports about pathological fractures requiring surgical stabilization in cases of antiviral drug-induced hypophosphatemic osteomalacia. We present the case of a 51-year-old man who sustained bilateral pathological hip fractures associated with antiviral drug-induced hypophosphatemic osteomalacia...
June 2018: Hip & Pelvis
Shabneez Hussain, Shahida Baloch, Azra Parvin, Akbar Najmuddin, Farhana Musheer, Mubashra Junaid, Rab Nawaz Memon, Fareeda Bhanbhro, Hayat Ullah, Bushra Moiz
Patient registry is a powerful tool for planning health care and setting groundwork for research. This survey reports a detailed registry of inherited bleeding disorders (IBD) and their management at a not-for-profit organization in a developing country to form the basis for planning development and research. We reviewed medical records of patients with IBD from 8 hemophilia treatment centers of Fatimid Foundation located in various cities. Information collected included sociodemographic data, diagnostic tests, severity of hemophilia A and B, number of bleeding episodes per year, site and frequency of hemarthrosis, and seropositivity for viral diseases...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
Shaohang Cai, Zejin Ou, Duan Liu, Lili Liu, Ying Liu, Xiaolu Wu, Tao Yu, Jie Peng
Background: We investigated whether metabolic syndrome exacerbated the risk of liver fibrosis among chronic hepatitis B patients and risk factors associated with liver steatosis and fibrosis in chronic hepatitis B patients with components of metabolic syndrome. Methods: This study included 1236 chronic hepatitis B patients with at least one component of metabolic syndrome. The controlled attenuation parameter and liver stiffness, patient information and relevant laboratory data were recorded...
May 2018: United European Gastroenterology Journal
M J Tong, C Q Pan
No abstract text is available yet for this article.
June 2018: Alimentary Pharmacology & Therapeutics
N H Ebel, P Rosenthal
No abstract text is available yet for this article.
June 2018: Alimentary Pharmacology & Therapeutics
Man-Fung Yuen, Ding-Shinn Chen, Geoffrey M Dusheiko, Harry L A Janssen, Daryl T Y Lau, Stephen A Locarnini, Marion G Peters, Ching-Lung Lai
Hepatitis B virus (HBV) is a hepatotropic virus that can establish a persistent and chronic infection in humans through immune anergy. Currently, 3.5% of the global population is chronically infected with HBV, although the incidence of HBV infections is decreasing owing to vaccination and, to a lesser extent, the use of antiviral therapy to reduce the viral load of chronically infected individuals. The course of chronic HBV infection typically comprises different clinical phases, each of which potentially lasts for decades...
June 7, 2018: Nature Reviews. Disease Primers
Michael W Rowley, Myunghan Choi, Steve Chen, Kevin Hirsch, Anil B Seetharam
BACKGROUND AND AIMS: Hepatic encephalopathy (HE) is a common complication of elective transjugular intrahepatic portosystemic shunt (TIPS) placement and is often successfully medically managed. Risk factors for refractory hepatic encephalopathy (RHE) necessitating revision of TIPS are not well defined. We evaluated the incidence, predictors, and outcomes of post-TIPS RHE necessitating TIPS revision. METHODS: In a retrospective cohort study of 174 consecutive patients undergoing elective TIPS placement (2010-2015), we evaluated the incidence of post-TIPS RHE...
June 5, 2018: Cardiovascular and Interventional Radiology
Gabriela Tirado-Conte, Josep Rodés-Cabau, Ramón Rodríguez-Olivares, Marco Barbanti, Thibault Lhermusier, Ignacio Amat-Santos, Stefan Toggweiler, Asim N Cheema, Antonio J Muñoz-García, Vicenc Serra, Francesca Giordana, Gabriela Veiga, Pilar Jiménez-Quevedo, Francisco Campelo-Parada, Lucca Loretz, Denise Todaro, María Del Trigo, José M Hernández-García, Bruno García Del Blanco, Francesco Bruno, José M de la Torre Hernández, Pieter Stella, Corrado Tamburino, Carlos Macaya, Luis Nombela-Franco
BACKGROUND: Chronic liver disease is a known risk factor for perioperative morbidity and mortality in patients undergoing cardiac surgery. Very little data exist about such patients treated with transcatheter aortic valve replacement (TAVR). Our objective was to evaluate early and late clinical outcomes in a large cohort of patients with liver disease undergoing TAVR and to determine predictive factors of mortality among these patients. METHODS AND RESULTS: This multicenter study collected data from 114 patients with chronic liver disease who underwent TAVR in 12 institutions...
March 2018: Circulation. Cardiovascular Interventions
Abdoulaye Seck, Fatou Ndiaye, Sarah Maylin, Babacar Ndiaye, François Simon, Anna L Funk, Arnaud Fontanet, Kazuaki Takahashi, Sheikh Mohammad Fazle Akbar, Shunji Mishiro, Raymond Bercion, Muriel Vray, Yusuke Shimakawa
Limited access to nucleic acid tests for hepatitis B virus (HBV) DNA is a significant barrier to the effective management of chronic HBV infection in resource-poor countries. Alternatively, HBV e antigen (HBeAg) may accurately indicate high viral replication. We assessed the diagnostic performance of three commercially available rapid diagnostic tests (RDTs) for HBeAg (SD Bioline, Insight and OneStep) against a quantitative chemiluminescent immunoassay (CLIA, Architect). Using stored sera from adults with chronic HBV infection, we tested RDTs in three groups in Senegal (48 HBeAg-positive, 196 HBeAg-negative, and 117 cases with high HBV DNA (≥ 106 IU/mL)) and one group in France (17 HBeAg-positive East Asians)...
June 4, 2018: American Journal of Tropical Medicine and Hygiene
Raquel Núñez-Ramos, Soledad Montoro, Marcello Bellusci, María Rosa Del Fresno-Valencia, Marta Germán-Díaz, Pedro Urruzuno, Enrique Medina, Javier Manzanares
PURPOSE: The aims of this study were to analyze the characteristics of patients with acute liver failure (ALF) in our center and evaluate the prognostic value of the Pediatric End-Stage Liver Disease (PELD) score calculated at admission. METHODS: A retrospective analysis of patients with ALF younger than 15 years between 2005 and 2013 was performed. Information collected included age, sex, etiology of ALF, laboratory tests, PELD score, stage of encephalopathy, and need for liver support devices such as MARS and/or liver transplant (LT) and survival...
June 2018: Pediatric Emergency Care
Daisuke Yamashita, Kazuyuki Shimada, Katsuyoshi Takata, Tomoko Miyata-Takata, Kei Kohno, Akira Satou, Ayako Sakakibara, Shigeo Nakamura, Naoko Asano, Seiichi Kato
Nodal cytotoxic molecule (CM)-positive peripheral T-cell lymphoma (CTL) has recently been recognized as a clinicopathologically distinct disease. To further characterize this disease, here we compared 58 patients with Epstein-Barr virus (EBV)-negative CTL to 48 patients with EBV-positive CTL. The two groups did not differ in histopathology, T-cell receptor (TCR) expression or rearrangement incidences, or survival curves. However, patients with EBV-negative CTL less frequently showed hepatic involvement (P = 0...
May 29, 2018: Cancer Science
Sheng Lou, Russell Taylor, Sandra Pearce, Mary Kuhns, Thomas Leary
BACKGROUND: Critical to the identification of HBV infection and the prevention of transfusion transmitted disease is the sensitive and accurate detection of Hepatitis B virus surface antigen (HBsAg). Improvements in HBsAg assay sensitivity approaching the performance of nucleic acid testing (NAT) are essential to further reduce the detection window for acute HBV infection in regions where NAT is not widely available. OBJECTIVES AND STUDY DESIGN: An improved HBsAg assay on the fully-automated Abbott ARCHITECT® platform was developed to improve sensitivity, mutant and genotype detection...
May 21, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Xiaoxue Xia, Jiang Chen, Jiayun Xia, Bin Wang, Hua Liu, Ling Yang, Ying Wang, Zongxin Ling
Objective This study was performed to investigate the role of probiotics ( Clostridium butyricum combined with Bifidobacterium infantis) in the treatment of minimal hepatic encephalopathy (MHE) in patients with hepatitis B virus (HBV)-induced liver cirrhosis. Methods Sixty-seven consecutive patients with HBV-induced cirrhosis without overt hepatic encephalopathy were screened using the number connection test and digit symbol test. The patients were randomized to receive probiotics (n = 30) or no probiotics (n = 37) for 3 months...
January 1, 2018: Journal of International Medical Research
Ana Isabel Plano Sánchez, Lucía Velasco Roces, Isabel Zapico García, Eva Lázaro López, Miguel Angel Calleja Hernandez, Maria Isabel Baena Parejo, Jaime Peña-Díaz
Sorafenib is an oral multikinase inhibitor with antiangiogenic and antiproliferative properties, and is used as the first-line treatment for patients with advanced hepatocellular carcinoma (HCC). Previous studies have identified an improvement in overall survival and progression-free survival in patients with a manageable toxicity profile. α-fetoprotein (AFP) has been revealed to be of great diagnostic and predictive value for tumour staging in multiple studies; however, its role as a predictive factor of response to treatment with sorafenib is not entirely clear...
June 2018: Oncology Letters
Xiao-Lu Ma, Jing Zhu, Jiong Wu, Lu Tian, Yao-Yi Gao, Chun-Yan Zhang, Yan Zhou, Qian Dai, Bei-Li Wang, Bai-Shen Pan, Jian Zhou, Jia Fan, Xin-Rong Yang, Wei Guo
The present study aimed to determine the levels of prothrombin induced by vitamin K absence-II (PIVKA-II) according to the Barcelona Clinic Liver Cancer (BCLC) staging system, to develop an appropriate strategy for managing hepatocellular carcinoma (HCC), particularly early HCC, and to investigate the value of PIVKA-II for predicting prognosis-associated pathological parameters. Clinical information of 117 patients with hepatitis B-associated HCC was retrospectively collected. Preoperative serum PIVKA-II and α-fetoprotein (AFP) levels were measured using a chemiluminescence method...
June 2018: Oncology Letters
(no author information available yet)
The mother-to-child transmission(MTCT) of hepatitis B virus (HBV) is the dominant cause of chronic HBV infection. In order to achieve the goal of "zero" MTCT before pregnancy, during pregnancy, and after pregnancy; standardized management for hepatitis HBV infection in women of childbearing age should be regulated. The content of this consensus includes: screening and treatment of HBV in pregnant women and women of childbearing age, treatment of hepatitis B during pregnancy, preventive measures and evaluation of combined immunization of hepatitis B immunoglobulin and hepatitis B vaccine in newborns, anti-viral therapy for all pregnant women with a high HBV DNA level and post-partum period related management...
March 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
Sami Akbulut, Murat Harputluoglu, Sezai Yilmaz
The risk of de novo hepatitis B virus infection is lower after liver transplant using hepatitis B core antibody-negative donors into negative recipients versus hepatitis B core antibody-positive donors but can occur. Here, we present a 34-year-old male patient with acute de novo hepatitis B virus that developed 7 months after successful liver transplant. The case we report here is the first in the literature with regard to both switch from tenofovir to entecavir treatment and the presentation of de novo acute hepatitis B virus after liver transplant...
May 23, 2018: Experimental and Clinical Transplantation
Mustafa Al-Zoughool, Zaina Al-Shehri
Needlestick and sharp instrument injuries are common in dental practice and present the risk of direct exposure to blood-borne pathogens, including hepatitis B virus. This cross-sectional study was carried out to determine the risk factors of injury and infection in three types of dental clinic in Riyadh, Saudi Arabia. A total of 274 male and 241 female dentists completed a structured questionnaire on demographic factors, compliance with infection control practices, and past exposure to injury and infection hazards...
January 1, 2018: Toxicology and Industrial Health
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