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Hepatitis B management

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https://www.readbyqxmd.com/read/29677540/ameliorating-effect-of-berbamine-on-hepatic-key-enzymes-of-carbohydrate-metabolism-in-high-fat-diet-and-streptozotocin-induced-type-2-diabetic-rats
#1
Sankaranarayanan Chandrasekaran, Nishanthi Ramajayam, Pugalendi Pachaiappan
BACKGROUND: Aberrations in the activities of key enzymes of carbohydrate metabolism is well documented in diabetes mellitus. Previous studies have shown that active ingredients in the extracts of Berberis aristata exhibits diverse pharmacological activities in animal models. OBJECTIVE: The present study was undertaken to investigate whether berbamine (BBM), an alkaloid from the roots of Berberis aristata can ameliorate the altered activities of carbohydrate metabolic enzymes in high fat diet (HFD)/streptozotocin (STZ) induced diabetic rats...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29672926/insights-into-the-etiology-associated-gene-regulatory-networks-in-hepatocellular-carcinoma-from-the-cancer-genome-atlas
#2
Veerabrahma Pratap Seshachalam, Karthik Sekar, Kam M Hui
BACKGROUND AND AIM: Hepatitis B virus, hepatitis C virus, alcoholic consumption and non-alcoholic fatty liver are the major known risk factors for Hepatocellular carcinoma (HCC). There have been very few studies comparing the underlying biological mechanisms associated with the different etiologies of HCC. In this study, we hypothesized the existence of different regulatory networks associated with different liver disease etiologies involved in hepatocarcinogenesis. METHODS: Using upstream regulatory analysis tool in ingenuity pathway analysis software, URs were predicted using differential expressed genes for HCC to facilitate the interrogation of global gene regulation...
April 19, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29672883/assessment-of-advanced-liver-fibrosis-and-the-risk-for-hepatic-decompensation-in-patients-with-congestive-hepatopathy
#3
REVIEW
Alexander Lemmer, Lisa B Van-Wagner, Daniel Ganger
Congestive hepatopathy (CH) arises from chronically elevated right sided heart pressures transmitted to the liver by passive venous congestion. Over time CH can lead to hepatic bridging fibrosis, decompensated cirrhosis, and hepatocellular carcinoma. Currently there are no evidence-based guidelines to direct appropriate screening or management of patients with CH partly because of the inability of current clinical tools (serum tests, imaging studies, liver stiffness measurements, and liver biopsy) to accurately estimate hepatic fibrosis or the risk for hepatic decompensation...
April 19, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29671563/rheumatoid-arthritis-common-questions-about-diagnosis-and-management
#4
Amy Wasserman
Rheumatoid arthritis is the most commonly diagnosed systemic inflammatory arthritis, with a lifetime prevalence of up to 1% worldwide. Women, smokers, and those with a family history of the disease are most often affected. Rheumatoid arthritis should be considered if there is at least one joint with definite swelling that is not better explained by another disease. In a patient with inflammatory arthritis, the presence of a rheumatoid factor and/or anti-citrullinated protein antibody, elevated C-reactive protein level, or elevated erythrocyte sedimentation rate is consistent with a diagnosis of rheumatoid arthritis...
April 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29666656/hepatitis-b-virus-infection-in-tanzania-current-status-and-challenges
#5
REVIEW
Semvua B Kilonzo, Daniel W Gunda, Bonaventura C T Mpondo, Fatma A Bakshi, Hyasinta Jaka
Hepatitis B is one of the most common infectious diseases in the world with high prevalence in most of sub-Saharan Africa countries. The complexity in its diagnosis and treatment poses a significant management challenge in the resource-limited settings including Tanzania, where most of the tests and drugs are either unavailable or unaffordable. This mini review aims at demonstrating the current status of the disease in the country and discussing the concomitant challenges in diagnosis, treatment, and prevention...
2018: Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29665097/real-world-use-of-elbasvir-grazoprevir-in-patients-with-chronic-hepatitis-c-retrospective-analyses-from-the-trio-network
#6
S L Flamm, B Bacon, M P Curry, S Milligan, C U Nwankwo, N Tsai, Z Younossi, N Afdhal
BACKGROUND: Elbasvir-grazoprevir is indicated for chronic hepatitis C virus (HCV) genotypes 1 and 4. AIMS: To evaluate the utilization and outcomes of chronic HCV patients treated with elbasvir-grazoprevir in the United States. METHODS: We conducted a retrospective cohort study of adults treated with elbasvir-grazoprevir with or without ribavirin for chronic HCV genotypes 1 or 4 infection. Data were collected from healthcare providers and specialty pharmacies through Innervation Platform, a proprietary, cloud-based disease management program from Trio Health...
April 17, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29663433/indeterminate-genotypes-of-hepatitis-c-virus-by-the-abbott-realtime-hcv-genotype-ii-assay-in-morocco-about-8-cases-resolved-by-a-sequencing-method
#7
Mesbahi Z, Kabbaj H, Malki E, Bouihat N, Qrafli M, Belfquih B, Marcil S, Challine D, Pawlotsky Jm, Bouvier Alias M, Seffar M
The early detection and genotyping of the hepatitis C virus (HCV) are important in the management of this infection. The genotype is the major factor influencing treatment decisions. That's why it is necessary to use fast and accurate methods in its determination. This study reports, over a period of 3 years (from May 2012 to July 2015), the percentage of indeterminate genotypes by the Abbott RealTime HCV Genotype II test and their results using a sequencing technique. Of 309 samples of 309 patients tested, 11 were indeterminate (4...
April 16, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29662832/hong-kong-consensus-statements-for-the-management-of-unresectable-hepatocellular-carcinoma
#8
Tom Tan-To Cheung, Philip Chong-Hei Kwok, Stephen Chan, Chin-Cheung Cheung, Ann-Shing Lee, Victor Lee, Hoi-Ching Cheng, Nam-Hung Chia, Charing C N Chong, Tak-Wing Lai, Ada L Y Law, Mai-Yee Luk, Chi Chung Tong, Thomas C C Yau
Background: Hepatocellular carcinoma (HCC) is highly prevalent in Hong Kong due to the high prevalence of chronic hepatitis B infection. Liver cancer is the fourth most common cancer and the third most common cause of cancer death. Due to the high case load, there is a high level of local expertise in treating HCC, and the full spectrum of treatment modalities is available. This document summarizes how these modalities should be used based on the latest evidence. Summary: In 2 meetings held in early 2017, a multidisciplinary group of Hong Kong clinicians, including liver surgeons, interventional radiologists, clinical oncologists, and medical oncologists, met to update local consensus statements for management of HCC...
March 2018: Liver Cancer
https://www.readbyqxmd.com/read/29661437/development-of-routine-dental-care-for-liver-transplant-outpatients
#9
S V Nascimento, A M Gonzalez, B Aguiar Roza, C F M G Pimentel, J Schirmer, S Mucci, D C Abranches
BACKGROUND: Liver transplantation has become commonplace for patients with end-stage liver disease. The liver is a bodily organ of great importance, and its dysfunction can cause significant complications throughout the body. Patients with hepatic disease should be able to acquire knowledge of the physiology of the liver via the dental profession, and it is also necessary to modify some aspects of dental treatment even in healthy patients. Problems such as excessive bleeding and hepatotoxicity caused by some of the drugs used in dental treatment can lead to a decrease in systemic health...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29656292/c-reactive-protein-and-procalcitonin-in-case-reports-of-drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-syndrome
#10
Simona T Hübner, Raffaela Bertoli, Alexandra E Rätz Bravo, Martina Schaueblin, Manuel Haschke, Kathrin Scherer, Alessandro Ceschi, Anne B Leuppi-Taegtmeyer
BACKGROUND: The spectrum of inflammatory marker response in DRESS (drug reaction with eosinophilia and systemic symptoms) syndrome has not been systematically characterized. METHODS: An epidemiological biomarker study of C-reactive protein (CRP) and procalcitonin (PCT) values in patients with DRESS syndrome reported at 2 regional pharmacovigilance centers in Switzerland or published in the medical literature 2008-2016 was performed. RESULTS: Ninety-four DRESS cases were studied...
April 13, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29649073/safety-of-targeted-prophylaxis-strategy-in-patients-with-resolved-hepatitis-b-virus-infection-receiving-rituximab-for-immune-mediated-diseases
#11
Michele Spinicci, Giacomo Emmi, Laura Dies, Alessandro Barilaro, Gianfranco Vitiello, Jessica Mencarini, Annalisa Cavallo, Alessandro Bartoloni, Filippo Bartalesi
OBJECTIVES: Rituximab (RTX) is a monoclonal antibody that is widely used in hematologic malignancies and immune-mediated diseases (IMID) and has been associated with the risk of hepatitis B virus reactivation (HBVr). Thus, antiviral prophylaxis is recommended before RTX treatment in all patients with chronic hepatitis B virus (HBV) infection and those with resolved infection affected by onco-hematological conditions. By contrast, the correct management of HBsAg-negative/HbcAb-positive patients candidates for RTX-containing regimens for IMID is still debated, owing to few data currently available in this setting...
April 11, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29643811/pristimerin-as-a-novel-hepatoprotective-agent-against-experimental-autoimmune-hepatitis
#12
Dina S El-Agamy, Ahmed A Shaaban, Hamdi H Almaramhy, Sarah Elkablawy, Mohamed A Elkablawy
Pristimerin (Pris) is bioactive natural quinonoid triterpene that has anti-inflammatory and anti-cancer activities. Meanwhile, its effect against hepatitis needs to be elucidated. This investigation aimed to evaluate the ability of Pris to protect against autoimmune hepatitis (AIH). A mouse model of AIH was established using single concanavalin A (Con A) intravenous injection. Mice were treated with Pris at two different doses (0.4 and 0.8 mg/kg) for 5 days prior to Con A challenge. Markers of hepatic injury, oxidative, inflammatory, and apoptotic damage were estimated...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29628202/health-status-of-afro-asian-refugees-in-an-italian-urban-area-a-cross-sectional-monocentric-study
#13
R Del Pinto, D Pietropaoli, U Russomando, P Evangelista, C Ferri
OBJECTIVES: The recent sociopolitical events in the Mediterranean and Middle Eastern areas have significantly impacted international migration flows. As disease prevalence and type are different among western and Afro-Asian countries, physicians dealing with refugees should be aware of their specific health needs. We aimed at evaluating the health status and disease history of refugees at their arrival in the urban area of L'Aquila (Italy). STUDY DESIGN: This is a monocentric cross-sectional study...
April 5, 2018: Public Health
https://www.readbyqxmd.com/read/29624802/serum-hepatitis-b-surface-antigen-correlates-with-fibrosis-and-necroinflammation-a-multicentre-perspective-in-china
#14
Zhang Peng, Du Hong-Bo, Tong Guang-Dong, Li Xiao-Ke, Sun Xue-Hua, Chi Xiao-Ling, Xing Yu-Feng, Zhou Zhen-Hua, Li Qin, Chen Bin, Wang Hui, Wang Li, Jin Hua, Mao De-Wen, Wang Xian-Bo, Wu Qi-Kai, Li Fen-Ping, Hu Xiao-Yu, Lu Bing-Jiu, Yang Zhi-Yun, Zhang Ming-Xiang, Shi Wei-Bing, He Qing, Li Yong, Jiang Kai-Ping, Xue Jing-Dong, Li Xiao-Dong, Jiang Jun-Min, Lu Wei, Tian Guang-Jun, Hu Zhen-Bin, Guo Jian-Chun, Li Cheng-Zhong, Deng Xin, Luo Xin-la, Li Feng-Yi, Zhang Xin-Wei, Zheng Ying-Jun, Zhao Gang, Wang Li-Chun, Wu Jian-Hua, Guo Hui, Mi Yu-Qiang, Gong Zuo-Jiong, Wang Cheng-Bao, Jiang Feng, Guo Peng, Yang Xian-Zhao, Shi Wei-Qun, Yang Hong-Zhi, Zhou Yong, Sun Ning-Ning, Jiao Yun-Tao, Gao Yue-Qiu, Zhou Da-Qiao, Ye Yong-An
The kinetics of serum hepatitis B surface antigen (HBsAg) during the natural history of hepatitis B virus (HBV) infection has been studied, but the factors affecting them remain unclear. AIMS: We aimed to investigate the factors affecting HBsAg titers, using data from multi-center, large-sized clinical trials in China. The baseline data of 1,795 patients in three multi-center trials were studied, and the patients were classified into three groups: hepatitis B early antigen (HBeAg)-positive chronic HBV infection (n=588), HBeAg-positive chronic hepatitis B (n=596), and HBeAg-negative chronic hepatitis B (n=611)...
April 6, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29619090/host-targeting-therapies-for-hepatitis-c-virus-infection-current-developments-and-future-applications
#15
REVIEW
Emilie Crouchet, Florian Wrensch, Catherine Schuster, Mirjam B Zeisel, Thomas F Baumert
Chronic hepatitis C virus (HCV) infection is a leading cause of chronic liver diseases and hepatocellular carcinoma (HCC) worldwide. In the past few years, anti-HCV therapies have undergone a revolution with the approval of multiple direct-acting antivirals (DAAs), which enable interferon-free treatments with considerable improvement of sustained virologic response in patients. Today, DAAs have become the standard of care for HCV therapy. However, several limitations remain, which include access to therapy, treatment failure in a subset of patients and persistent risk of HCC development following cure in patients with advanced fibrosis...
2018: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/29610518/the-beta-secretase-bace1-regulates-the-expression-of-insulin-receptor-in-the-liver
#16
Paul J Meakin, Anna Mezzapesa, Eva Benabou, Mary E Haas, Bernadette Bonardo, Michel Grino, Jean-Michel Brunel, Christèle Desbois-Mouthon, Sudha B Biddinger, Roland Govers, Michael L J Ashford, Franck Peiretti
Insulin receptor (IR) plays a key role in the control of glucose homeostasis; however, the regulation of its cellular expression remains poorly understood. Here we show that the amount of biologically active IR is regulated by the cleavage of its ectodomain, by the β-site amyloid precursor protein cleaving enzyme 1 (BACE1), in a glucose concentration-dependent manner. In vivo studies demonstrate that BACE1 regulates the amount of IR and insulin signaling in the liver. During diabetes, BACE1-dependent cleavage of IR is increased and the amount of IR in the liver is reduced, whereas infusion of a BACE1 inhibitor partially restores liver IR...
April 3, 2018: Nature Communications
https://www.readbyqxmd.com/read/29606603/surgical-management-of-hepatocellular-carcinoma-within-and-beyond-bclc-indications-in-a-middle-volume-center
#17
M Garancini, S Nespoli, F Romano, F Uggeri, L Degrate, S Okolicsanyi, L Gianotti
AIM OF THE STUDY: Current criteria for hepatic resection in patients with hepatocellular carcinoma (HCC) according to Barcellona Clinic Liver Cancer (BCLC) classification is debated. Actually, patients with multinodular or large HCC>5cm are excluded from surgical treatment following the algorithm, but several studies from referral centers showed that such patients may benefit from surgical resection in the clinical practice. The aim of this study was to compare short- and long-term outcomes after liver resection for HCC in stage 0/A or B in a middle volume center...
March 29, 2018: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/29605773/peel-flour-of-passiflora-edulis-var-flavicarpa-supplementation-prevents-the-insulin-resistance-and-hepatic-steatosis-induced-by-low-fructose-diet-in-young-rats
#18
M J Goss, M L O Nunes, I D Machado, L Merlin, N B Macedo, A M O Silva, T M B Bresolin, J R Santin
The increase in fructose consumption in the last decades has an important correlation with the growth of overweight population. Fructose is a monosaccharide found in fruits, vegetables and honey, however, it is widely used in processed food and beverages such as sweeteners. This monosaccharide is metabolized in the liver, so it can produce glucose, lactate, triglycerides, free fatty acids and uric acid, which are responsible for negative effects on the liver and extrahepatic tissues. One effect of the high consumption of fructose is the resistance to Insulin, which appears to be an important issue in the development of metabolic abnormalities observed in animals that were subjected to a high fructose diet...
March 29, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29599899/reactivation-of-hepatitis-b-after-liver-transplantation-current-knowledge-molecular-mechanisms-and-implications-in-management
#19
REVIEW
Ranjit Chauhan, Shilpa Lingala, Chiranjeevi Gadiparthi, Nivedita Lahiri, Smruti R Mohanty, Jian Wu, Tomasz I Michalak, Sanjaya K Satapathy
Chronic hepatitis B (CHB) is a major global health problem affecting an estimated 350 million people with more than 786000 individuals dying annually due to complications, such as cirrhosis, liver failure and hepatocellular carcinoma (HCC). Liver transplantation (LT) is considered gold standard for treatment of hepatitis B virus (HBV)-related liver failure and HCC. However, post-transplant viral reactivation can be detrimental to allograft function, leading to poor survival. Prophylaxis with high-dose hepatitis B immunoglobulin (HBIG) and anti-viral drugs have achieved remarkable progress in LT by suppressing viral replication and improving long-term survival...
March 27, 2018: World Journal of Hepatology
https://www.readbyqxmd.com/read/29597209/feasibility-of-watch-and-wait-management-before-repeat-hepatectomy-for-colorectal-liver-metastases
#20
Yoji Kishi, Satoshi Nara, Minoru Esaki, Kazuaki Shimada
BACKGROUND: Whether repeat hepatectomy for colorectal liver metastases should be performed after chemotherapy or observation is unclear. METHODS: We selected patients with resectable hepatic recurrence after their first hepatectomies performed between 2000 and 2015. They were classified according to the further treatment: Group A, prompt repeat hepatectomy; Group B, observation; and Group C, ≤6 months of chemotherapy. In Group B/C, patients who later underwent hepatectomy and those who did not due to disease progression were classified as B1/C1 and B2/C2, respectively...
March 29, 2018: Digestive Surgery
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