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Hepatitis B management

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https://www.readbyqxmd.com/read/29212443/the-current-incidence-prevalence-and-residual-risk-of-hepatitis-b-viral-infections-among-voluntary-blood-donors-in-china
#1
Ling Li, Tingting Han, Liang Zang, Libin Niu, Weifang Cheng, Hongkeng Lin, Ka Yi Li, Ruan Cao, Binghai Zhao, Yuqiang Liu, Guojin Ou, Xiao Liu, Yingjie Qi, Yanhua Li, Zhong Liu
BACKGROUND: There are few data available on the prevalence, incidence, and residual risk of transfusion-transmitted HBV (TT-HBV) infections among Chinese blood donors. This study investigated the demographic characteristics of blood donors, as well as the prevalence, incidence, and residual risk (RR) of TT-HBV infections in six large blood centers in different regions of China. METHODS: The demographic characteristics and HBV screening test results of blood donors from six blood centers in different regions in China were collected and analyzed...
December 6, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29208877/significance-of-age-spleen-platelet-ratio-index-aspri-to-exclude-cirrhosis-in-patients-with-chronic-hepatitis-b
#2
F Ahmed, M A Mahtab, S Rahman, M F Karim, M Khan, T Akther, A H Manik, C R Debnath
Liver biopsy is an integral part of management of patients with Chronic Hepatitis B (CHB), which is helpful in confirming diagnosis, assessing grade of inflammation and stage of fibrosis and also in guiding treatment strategy. Although liver biopsy is relatively safe, morbidity occurs in 0.2-2% of patients. Hence various non-invasive markers, like AST-ALT Ratio (AAR), Age-Platelet Index (API), AST to Platelet Ratio Index (APRI), Fibroscan etc. have been developed worldwide to asses liver histology. Age-Spleen-Platelet Ratio Index (ASPRI) is new in this series...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29204927/augmented-bioavailability-of-felodipine-through-an-%C3%AE-linolenic-acid-based-microemulsion
#3
Mahendra Singh, Jovita Kanoujia, Poonam Parashar, Malti Arya, Chandra B Tripathi, V R Sinha, Shailendra K Saraf, Shubhini A Saraf
The oral bioavailability of felodipine, a dihydropyridine calcium channel antagonist, is about 15%. This may be due to poor water solubility, and a lower intestinal permeability than a BCS class I drug, and hepatic first-pass metabolism of the drug. Many drugs are unpopular due to solubility issues. The goal of this study was to develop and optimize a felodipine-containing microemulsion to improve the intestinal permeability and bioavailability of the drug. The felodipine microemulsions were developed with the selected components, i...
December 4, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29201802/hepatic-metastasis-from-colorectal-cancer
#4
Alan I Valderrama-Treviño, Baltazar Barrera-Mera, Jesús C Ceballos-Villalva, Eduardo E Montalvo-Javé
The liver is the most common site of metastasis in patients with colorectal cancer due to its anatomical situation regarding its portal circulation. About 14 to 18% of patients with colorectal cancer present metastasis at the first medical consultation, and 10 to 25% at the time of the resection of the primary colorectal cancer. The incidence is higher (35%) when a computed tomography (CT) scan is used. In the last decades, a significant increase in the life expectancy of patients with colorectal cancer has been achieved with different diagnostic and treatment programs...
July 2017: Euroasian Journal of Hepato-Gastroenterology
https://www.readbyqxmd.com/read/29201772/managing-encephalopathy-in-the-outpatient-setting
#5
REVIEW
Tarana Gupta, Sahaj Rathi, Radha K Dhiman
In cirrhosis of liver, hepatic encephalopathy (HE) has an important impact on health-related quality of life. It is important to define whether HE is episodic, recurrent, or persistent; types A, B, or C; overt HE or covert HE; and spontaneous or precipitated. The overt HE is clinically evident and needs hospitalization. Nonabsorbable disaccharides, rifaximin, and probiotics are proven to be useful in the treatment of overt HE. Covert HE includes both minimal HE and grade I HE. It is not apparent on routine clinical examination...
January 2017: Euroasian journal of hepato-gastroenterology
https://www.readbyqxmd.com/read/29198916/anxiety-related-adverse-events-following-immunization-aefi-a-systematic-review-of-published-clusters-of-illness
#6
Anagha Loharikar, Tiffany A Suragh, Noni E MacDonald, Madhava R Balakrishnan, Oleg Benes, Smaragda Lamprianou, Terri B Hyde, Michael M McNeil
BACKGROUND: Clusters of anxiety-related adverse events following immunization (AEFI) have been observed in several countries and have disrupted country immunization programs. We conducted a systematic literature review to characterize these clusters, to generate prevention and management guidance for countries. METHODS: We searched seven peer-reviewed databases for English language reports of anxiety-related AEFI clusters (≥2 persons) with pre-specified keywords across 4 categories: symptom term, cluster term, vaccine term, and cluster AEFI phenomenon term/phrase...
November 29, 2017: Vaccine
https://www.readbyqxmd.com/read/29197859/evaluation-of-the-aptima-hbv-quant-assay-vs-the-cobas-taqman-hbv-test-using-the-high-pure-system-for-the-quantitation-of-hbv-dna-in-plasma-and-serum-samples
#7
Gunnar Schalasta, Anna Börner, Andrea Speicher, Martin Enders
BACKGROUND: Proper management of patients with chronic hepatitis B virus (HBV) infection requires monitoring of plasma or serum HBV DNA levels using a highly sensitive nucleic acid amplification test. Because commercially available assays differ in performance, we compared herein the performance of the Hologic Aptima HBV Quant assay (Aptima) to that of the Roche Cobas TaqMan HBV test for use with the high pure system (HPS/CTM). METHODS: Assay performance was assessed using HBV reference panels as well as plasma and serum samples from chronically HBV-infected patients...
December 4, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29197421/epidemiology-of-viral-hepatitis-in-the-republic-of-congo-review
#8
Laure Stella Ghoma Linguissi, Celine Nguefeu Nkenfou
OBJECTIVE: Considered an endemic zone, Republic of Congo has a high seroprevalence rate of hepatitis B and C virus. To know the extent of hepatitis infection as a public health problem, we reviewed published literature and other sources for reports of these viral infections in the country. RESULTS: High seroprevalence of HBV and HCV carriage in blood donors were observed in studies confirming Congo's place in the hyperendemic area of HBV and HCV infection. These prevalence were compared by Chi square test...
December 2, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29197175/pharmacokinetics-of-diclofenac-and-hydroxypropyl-%C3%AE-cyclodextrin-hp%C3%AE-cd-following-administration-of-injectable-hp%C3%AE-cd-diclofenac-in-subjects-with-mild-to-moderate-renal-insufficiency-or-mild-hepatic-impairment
#9
Douglas A Hamilton, Cynthia C Ernst, William G Kramer, Donna Madden, Eric Lang, Edward Liao, Peter G Lacouture, Atulkumar Ramaiya, Daniel B Carr
Given their established analgesic properties, nonsteroidal anti-inflammatory drugs (NSAIDs) represent an important postoperative pain management option. This study investigated: (1) the effects of mild or moderate renal insufficiency and mild hepatic impairment on the pharmacokinetics (PK) of diclofenac and hydroxypropyl-β-cyclodextrin (HPβCD) following administration of the injectable NSAID HPβCD-diclofenac; and (2) the PK of HPβCD following administration of HPβCD-diclofenac and intravenous itraconazole formulated with HPβCD in healthy adults...
December 2, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29194939/management-of-drug-interactions-with-direct-acting-antivirals-in-dutch-hiv-hepatitis-c-virus-coinfected-patients-adequate-but-not-perfect
#10
E J Smolders, C Smit, Ctmm de Kanter, Asm Dofferhoff, J E Arends, K Brinkman, B Rijnders, M van der Valk, P Reiss, D M Burger
OBJECTIVES: Direct-acting antivirals (DAAs) for treatment of chronic hepatitis C virus (HCV) infection can cause drug-drug interactions (DDIs) with combination antiretroviral therapy (cART) and non-cART co-medication. We mapped how physicians manage DDIs between DAAs and co-medication and analysed treatment outcomes. METHODS: Data were prospectively collected as part of the ATHENA HIV observational cohort and retrospectively analysed. Dutch patients with HIV/HCV coinfection who initiated treatment with DAAs between January 2015 and May 2016 were included...
December 1, 2017: HIV Medicine
https://www.readbyqxmd.com/read/29193542/improved-performance-of-quantitative-collagen-parameters-versus-standard-histology-in-longitudinal-assessment-of-non-advanced-liver-fibrosis-for-chronic-hepatitis-b
#11
Yan Wang, Xieer Liang, Jinlian Yang, Hao Wang, Deming Tan, Shijun Chen, Jun Cheng, Yongpeng Chen, Jian Sun, Fan Rong, Wei Yang, Hailin Liu, Zhipeng Liu, Yongjian Zheng, Jiaen Liang, Shiying Li, Zhihong Liu, Jinlin Hou
Monitoring longitudinal non-advanced fibrosis is a more common scenario in management of chronic hepatitis B (CHB), for which however, current evaluation methods generally lack sufficient performance. We conducted a proof-of-concept study to evaluate the performance of quantitative fibrous collagen parameters (q-FP) in the assessment. Data sets from a prior CHB trial (NCT00962533) with mostly mild-to-moderate fibrosis participants were used for this study. 301 subjects with paired liver biopsies were consecutively included...
November 29, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29193010/early-versus-late-recurrence-of-intrahepatic-cholangiocarcinoma-after-resection-with-curative-intent
#12
X-F Zhang, E W Beal, F Bagante, J Chakedis, M Weiss, I Popescu, H P Marques, L Aldrighetti, S K Maithel, C Pulitano, T W Bauer, F Shen, G A Poultsides, O Soubrane, G Martel, B G Koerkamp, E Itaru, T M Pawlik
BACKGROUND: The objective of this study was to investigate the characteristics, treatment and prognosis of early versus late recurrence of intrahepatic cholangiocarcinoma (ICC) after hepatic resection. METHODS: Patients who underwent resection with curative intent for ICC were identified from a multi-institutional database. Data on clinicopathological characteristics, initial operative details, timing and sites of recurrence, recurrence management and long-term outcomes were analysed...
November 28, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29191641/vena-cavoscopy-in-the-assessment-of-intraluminal-vena-caval-tumor-involvement
#13
Jeffrey Loh-Doyle, Sumeet Bhanvadia, Mukul B Patil, Hooman Djaladat, Siamak Daneshmand
OBJECTIVE: To improve confirmation of complete tumor thrombus removal in advanced malignancy, we report on our experience using intraoperative vena cavoscopy using a flexible cystoscope to confirm complete thrombus resection. Patients with renal cell carcinoma (RCC) or testicular cancer (TC) associated with inferior vena caval tumor involvement benefit from surgical resection of the primary tumor and tumor thrombus. Intraoperative assessment of the vena cava represents a technical challenge, particularly when the thrombus is friable, involves the hepatic veins, or there is caudal extension of thrombus towards the bifurcation...
November 27, 2017: Urology
https://www.readbyqxmd.com/read/29188773/sorafenib-tosylate-ribavirn-and-sofosbuvir-combination-therapy-for-hcv-virus-infected-patients-with-decompensated-liver-cancer
#14
Bushra Munir, Bilal Ahmed, Shumaila Kiran, Fatima Jalal, Muhammad Kashif Zahoor, Saba Shehzadi, Sadaf Oranab, Sayed Kashif Kamran, Abdul Ghaffar
Hepatitis C is the most common health problem worldwide and is major cause of death due to proliferation of hepatocellular carcinoma. The medicines available for HCV treatment overcome up-to 95% complications of HCV. However, liver cancer needs some additional care. Normally Sorafenib tosylate 200 mg is recommended for liver cancer. There is no such trial in which this drug could effectively be used in combination of direct acting antivirals for HCV. The study was conducted for HCV patients (n=30) with liver cancer having decompensated stage...
November 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29187150/identification-of-pathogens-for-differential-diagnosis-of-fever-with-jaundice-in-the-central-african-republic-a-retrospective-assessment-2008-2010
#15
Christelle Luce Bobossi Gadia, Alexandre Manirakiza, Gaspard Tekpa, Xavier Konamna, Ulrich Vickos, Emmanuel Nakoune
BACKGROUND: Febrile jaundice results clinically in generalized yellow coloration of the teguments and mucous membranes due to excess plasma bilirubin, accompanied by fever. Two types are found: conjugated and unconjugated bilirubin jaundice. Jaundice is a sign in several diseases due to viruses (viral hepatitis and arbovirus), parasites (malaria) and bacteria (leptospirosis). In the Central African Republic (CAR), only yellow fever is included on the list of diseases for surveillance...
November 29, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29170919/current-advances-in-the-elimination-of-hepatitis-b-in-china-by-2030
#16
REVIEW
Shuye Zhang, Fusheng Wang, Zheng Zhang
With its 78 million chronic carriers, hepatitis B virus (HBV) infection is still one of the leading public health challenges in China. Over the last two decades, China has made great progress on the prevention of HBV transmission through national vaccination programs. Zero transmission from mother to infant has been proposed as the current goal. Available anti-HBV therapy is efficacious in suppressing HBV replication; however, it fails to completely cure patients with chronic hepatitis B and even requires lifelong treatment...
November 23, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/29162286/medical-management-of-a-subretinal-klebsiella-pneumoniae-abscess-with-excellent-visual-outcome-without-performing-vitrectomy
#17
A Martel, B Butet, J C Ramel, D Martiano, S Baillif
OBJECTIVE: To report the case of a Klebsiella pneumoniae endogenous endophthalmitis (KPEE) of hepatic and urinary origin that was successfully treated with systemic antibiotherapy and 13 intravitreal antibiotics injections without performing a vitrectomy. PATIENT AND METHOD: Case report of a 60-year-old man with a subretinal abscess in the left eye that developed 3 days after initial presentation for K. pneumoniae bacteremia, liver abscess and urinary tract infection...
November 18, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29158999/recurrent-primary-suprahepatic-abscess-due-to-providencia-stuartii-a-rare-phenomenon
#18
Kyawzaw Lin, Aung Naing Lin, Sandar Linn, Madhavi Reddy, Anjali Bakshi
Gram-negative urease-producing bacilli, Providencia stuartii (P. stuartii), is reported in urinary tract infections, gastroenteritis, and bacteremia in humans but they rarely present with a hepatic abscess. We present a rare case of a recurrent suprahepatic cyst due to P. stuartii in a 45-year-old female, intravenous ( IV) heroin abuser with chronic hepatitis B and C. A 45-year-old female with 10 days status post right suprahepatic abscess drainage presented with recurrent, right, upper quadrant abdominal pain for one day...
September 16, 2017: Curēus
https://www.readbyqxmd.com/read/29158080/risk-stratified-management-strategies-for-hbv-reactivation-in-ra-patients-receiving-biological-and-targeted-therapy-a-narrative-review
#19
REVIEW
Yi-Ming Chen, Sheng-Shun Yang, Der-Yuan Chen
It is estimated that more than two billion people around the world have been infected by Hepatitis B virus (HBV). Reactivation of HBV (rHBV) is a potentially fatal complication after biological therapy. With the increasing use of biologics and targeted therapy in rheumatoid arthritis (RA) patients who are refractory to conventional synthetic disease-modifying anti-rheumatic drugs, rHBV in those with past infection has become increasingly problematic, especially in HBV-endemic regions. Among those receiving biological therapy, the risk of rHBV varies according to the status of HBV infection and the degree of biologic-related immunosuppression...
November 5, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/29156049/management-of-pregnant-women-and-children-focusing-on-preventing-mother-to-infant-transmission
#20
Huey-Ling Chen, Wan-Hsin Wen, Mei-Hwei Chang
Hepatitis B virus (HBV) immunization has been effectively preventing chronic HBV infection with >90% efficacy in countries with universal neonatal immunization. Perinatal mother-to-infant transmission of HBV remains the major cause of chronic HBV infection despite immunization. Maternal hepatitis B e-antigen (HBeAg) and high viral load have been noted to be the most important risk factors for transmission. In recent years, short-term antiviral therapy for pregnant women in the third trimester has been shown to be highly effective in reducing 90% of vaccine failure in children...
November 16, 2017: Journal of Infectious Diseases
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