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https://www.readbyqxmd.com/read/29023986/evaluation-of-short-and-long-term-efficacy-of-chemoradiotherapy-for-advanced-cervical-cancer-using-hsp70-protein-combined-with-multimodal-mri
#1
Yun-Xiang Qi, Kun Liu, Jun Yin, Lu Li
This study aims to evaluate the efficacy of chemoradiotherapy for advanced cervical cancer using heat shock protein 70 (HSP70) combined with multimodal MRI. The protein expressions of HSP70 in biopsy specimens obtained from 101 patients with cervical cancer were detected by immunohistochemistry. Plain MRI scan, DWI, DCE-MR and MRS were performed before and after a period of six months of chemoradiotherapy. All patients were assigned into the complete response (CR) and partial response (PR) groups. HSP70 protein expression, tumor diameter and tumor volume were lower in the CR group than in the PR group...
October 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29023379/effect-of-early-pelvic-binder-use-in-the-emergency-management-of-suspected-pelvic-trauma-a-retrospective-cohort-study
#2
Sheng-Der Hsu, Cheng-Jueng Chen, Yu-Ching Chou, Sheng-Hao Wang, De-Chuan Chan
BACKGROUND: We aimed to evaluate the effect of early pelvic binder use in the emergency management of suspected pelvic trauma, compared with the conventional stepwise approach. METHODS: We enrolled trauma patients with initial stabilization using a pelvic binder when suspecting pelvic injury. The inclusion criteria were traumatic injury requiring a trauma team and at least one of the following: a loss of consciousness or a Glasgow coma score (GCS) of <13; systolic blood pressure of <90 mmHg; falling from ≥6 m; injury to multiple vital organs; and suspected pelvic injury...
October 12, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29021673/risk-factors-for-30-day-outcomes-in-elective-anterior-versus-posterior-cervical-fusion-a-matched-cohort-analysis
#3
John K Yue, Pavan S Upadhyayula, Hansen Deng, David C Sing, Joseph D Ciacci
OBJECTIVE: Cervical spine fusion is the preferred treatment modality for a variety of degenerative and/or myelopathic disorders. Surgeons select between two approaches (anterior or posterior cervical fusion [ACF; PCF]) based on pathoanatomical features and spinal levels involved. Complications and outcome profiles between the approaches following elective surgery have not been systematically investigated. METHODS: Adult patients undergoing elective ACF or PCF were extracted from the American College of Surgeons National Surgical Quality Improvement Program years 2011-2014...
July 2017: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/29017315/thyroid-cytology-the-japanese-system-and-experience-at-yamashita-thyroid-hospital
#4
Shinya Satoh, Hiroyuki Yamashita, Kennichi Kakudo
In Japan, fine needle aspiration (FNA) cytology is the most important diagnostic modalities for triaging patients with thyroid nodules. A clinician (endocrinologist, endocrine surgeon, or head and neck surgeon) generally performs FNA cytology at the outpatient clinic, and ultrasound (US)-guided FNA is widespread because US is extremely common and most clinicians are familiar with it. Although almost all FNA thyroid samples are examined by certified cytopathologists and pathologists, some clinicians assess cytological specimens themselves...
October 11, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29016776/atrial-fibrillation-is-associated-with-decreased-total-cerebral-blood-flow-and-brain-perfusion
#5
Marianna Gardarsdottir, Sigurdur Sigurdsson, Thor Aspelund, Hrafnhildur Rokita, Lenore J Launer, Vilmundur Gudnason, David O Arnar
Aims: Atrial fibrillation (AF) has been associated with cognitive impairment. Additionally, brain volume may be reduced in individuals with AF. Potential causes may include cerebral micro-embolism or reduced stroke volume due to the beat-to-beat variation in AF. The aims of this study were to measure cerebral blood flow and estimate whole brain perfusion in elderly individuals with and without AF. Methods and results: Blood flow in the cervical arteries was measured with phase contrast MRI and brain perfusion estimated in a large cohort from the AGES-Reykjavik Study...
August 9, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29016436/trends-and-disparities-in-cervical-spine-fusion-procedures-utilization-in-the-new-york-state
#6
Rui Feng, Mark Finkelstein, Khawaja Bilal, Eric K Oermann, Michael Palese, John Caridi
STUDY DESIGN: A retrospective review of the Statewide Planning and Research Cooperative System database of the New York State. OBJECTIVE: This study examined the rate of increase of cervical spine fusion procedures at low-, medium-, and high-volume hospitals, and analyzed racial and socioeconomic characteristics of the patient population treated at these three volume categories. SUMMARY OF BACKGROUND DATA: There has been a steady increase in spinal fusion procedures performed each year in the US, especially cervical and lumbar fusion...
October 9, 2017: Spine
https://www.readbyqxmd.com/read/28993442/in-room-assessment-of-intravascular-velocity-from-time-resolved-rotational-angiography-in-patients-with-arteriovenous-malformation-a-pilot-study
#7
Chung Jung Lin, Huai Che Yang, Ai Chi Chien, Wan Yuo Guo, Chih Chun Wu, Sheng Che Hung, Ko Kung Chen, Hsiu Mei Wu, Chao Bao Luo, Wei Fa Chu, Jia Sheng Hong, Chun Shien Frank Wu
BACKGROUND: Time-resolved rotational angiography (t-RA) enables interventionists to better comprehend complex arteriovenous malformations (AVMs), thereby facilitating endovascular treatment. However, its use in evaluating hemodynamic changes has rarely been explored. OBJECTIVE: This study uses t-RA to estimate intravascular flow in patients with AVM to compare this with flow in the normal population. METHODS: Patients with available t-RA scans were prospectively categorized into one of three groups: hemorrhagic AVM, non-hemorrhagic AVM and control...
October 9, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28993108/evaluation-of-interfractional-variation-of-organs-and-displacement-of-catheters-during-high-dose-rate-interstitial-brachytherapy-for-gynecologic-malignancies
#8
Soyoung Lee, Ellis Rodney, Bryan Traughber, Tithi Biswas, Valdir Colussi, Tarun Podder
PURPOSE: To investigate the dosimetric effects due to interfractional changes in catheter position and variation in patient's anatomy during the course of interstitial high-dose-rate (HDR) brachytherapy. METHODS AND MATERIALS: A total of 15 patients with either cervical or vaginal cancer underwent interstitial HDR brachytherapy. Interstitial catheters and fiducials were placed under fluoroscopy and intraoperative 3T MRI to confirm the desired catheter placement for adequate target volume coverage...
October 6, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28987316/bypass-for-symptomatic-in-stent-carotid-restenosis
#9
Francesco Stilo, Pasqualino Sirignano, Nunzio Montelione, Wassim Mansour, Laura Capoccia, Vincenzo Catanese, Francesco Spinelli, Francesco Speziale
BACKGROUND: To evaluate early and long-term outcomes of symptomatic patients treated for in-stent carotid restenosis (ISR) with carotid bypass (CB). METHODS: Data were retrospectively collected from a prospectively compiled database on patients treated with CB in two high-volume Italian centers between 2008 and 2016, for symptomatic high-grade ISR after CAS. After carotid endarterectomy and stent removal, a greater saphenous vein (GSV) was preferentially employed as the graft; when the GSV was not accessible, a 6mm polytetrafluoroethylene (PTFE) graft was implanted...
September 20, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28975498/factors-associated-with-changes-in-vaginal-length-and-diameter-during-pelvic-radiotherapy-for-cervical-cancer
#10
Jumara Martins, Ana Francisca Vaz, Regina Celia Grion, Sérgio Carlos Barros Esteves, Lúcia Costa-Paiva, Luiz Francisco Baccaro
OBJECTIVES: This study reports the incidence and factors associated with vaginal stenosis and changes in vaginal dimensions after pelvic radiotherapy for cervical cancer. METHODS: A descriptive longitudinal study with 139 women with cervical cancer was conducted from January 2013 to November 2015. The outcome variables were vaginal stenosis assessed using the Common Terminology Criteria for Adverse Events (CTCAE v3.0) and changes in vaginal diameter and length after the end of radiotherapy...
October 3, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28969256/role-of-functional-magnetic-resonance-imaging-derived-parameters-as-imaging-biomarkers-and-correlation-with-clinicopathological-features-in-carcinoma-of-uterine-cervix
#11
Ramireddy Jeba Karunya, Putta Tharani, Subhashini John, Ramani Manoj Kumar, Saikat Das
INTRODUCTION: Magnetic Resonance Imaging (MRI) is emerging as a powerful tool in the evaluation and management of cervical cancer. The role of Diffusion Weighted Imaging (DWI) with Apparent Diffusion Coefficient (ADC) as a non-invasive imaging biomarker is promising in characterization of the tumour and prediction of response. AIM: The aim of this study was to evaluate the role of conventional MRI and diffusion weighted MRI in predicting clinicopathological prognostic factors...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28967294/an-autonomic-neuroprosthesis-non-invasive-electrical-spinal-cord-stimulation-restores-autonomic-cardiovascular-function-in-individuals-with-spinal-cord-injury
#12
Aaron A Phillips, Jordan W Squair, Dimitry Sayenko, Victor Reggie Edgerton, Yury Gerasimenko, Andrei V Krassioukov
Despite autonomic dysfunction after spinal cord injury being the major cause of death and top health priority, the clinical management options for these conditions are limited to drugs with delayed onset and non-pharmacological interventions with equivocal effectiveness. We tested the capacity of electrical stimulation, applied transcutaneously over the spinal cord, to manage autonomic dysfunction in the form of orthostatic hypotension after spinal cord injury. We assessed beat-by-beat blood pressure (BP), stroke volume and cardiac contractility (dP/dt; Finometer), as well as cerebral blood flow (transcranial Doppler) in five individuals with motor complete spinal cord injury (four cervical, one thoracic) during an orthostatic challenge with and without transcutaneous electrical stimulation applied at the TVII level...
October 1, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28957944/experimental-rat-model-for-cervical-compressive-myelopathy
#13
Yasushi Ijima, Takeo Furuya, Masao Koda, Yusuke Matsuura, Junya Saito, Mitsuhiro Kitamura, Takuya Miyamoto, Sumihisa Orita, Kazuhide Inage, Takane Suzuki, Masashi Yamazaki, Seiji Ohtori
Previously, a rat model of chronic compressive myelopathy that uses a water-absorbing polymer inserted under a spinal lamina was reported. However, the best size and coefficient of expansion of the polymer sheet have not yet been established. The aim of the present study was to optimize these properties in an ideal rat model of cervical compressive myelopathy. Thirty rats were used in this study. A sheet of water-absorbing polymer was inserted under the cervical laminae. Rats were divided randomly into five experimental groups by the expansion rate (350 or 200%) and thickness (0...
September 27, 2017: Neuroreport
https://www.readbyqxmd.com/read/28954503/place-of-residence-does-not-significantly-influence-radiological-morphology-of-cervical-cancer
#14
Franciszek Burdan, Agnieszka Mocarska, Robert Klepacz, Jerzy Walocha, Tomasz Kubiatowski, Dariusz Surdyka, Dariusz Kieszko, Krzysztof Patyra, Iwonna Żelzowska-Cieślińska, Elżbieta Starosławska
INTRODUCTION AND OBJECTIVE: Cervical squamous cell carcinoma is one of the most common malignancies of women. Its incidence and morphology was analyzed based on the magnetic resonance (MR) data among rural and urban residents. MATERIAL AND METHODS: The study involved 61 Caucasian women (58.26±9.63 years) preliminary diagnosed with a cervical cancer without any previous treatment. Standard MR examination, including diffusion weighted imagining, apparent diffusion coefficient (ADC) value measurement and dynamic contrast enhancement, was performed...
September 21, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28953118/large-loop-excision-of-the-transformation-zone-versus-true-cone-biopsy-electrode-excision-a-randomized-trial
#15
Ziad Hilal, Günther A Rezniczek, Nariman El-Fizazi, Clemens B Tempfer
OBJECTIVES: The aim of the study was to compare two conization techniques, large loop excision of the transformation zone (LLETZ), and true cone biopsy electrode excision (TCBEE) in women with cervical dysplasia. MATERIALS AND METHODS: In a randomized clinical trial, we compared LLETZ and TCBEE in women undergoing surgical treatment of cervical dysplasia in a 1:1 ratio. The primary endpoint was resection margin status (RMS), secondary endpoints were fragmentation of the surgical specimen, resection volume, operation time, time to complete hemostasis, blood loss, intraoperative and postoperative complications, surgeon's preference, and patient's postoperative pain, estimated by an 11-level visual analog scale (nVAS11), and a 5-level pictogram...
October 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28953113/asccp-colposcopy-standards-colposcopy-quality-improvement-recommendations-for-the-united-states
#16
Edward J Mayeaux, Akiva P Novetsky, David Chelmow, Francisco Garcia, Kim Choma, Angela H Liu, Theognosia Papasozomenos, Mark H Einstein, L Stewart Massad, Nicolas Wentzensen, Alan G Waxman, Christine Conageski, Michelle J Khan, Warner K Huh
OBJECTIVES: The American Society for Colposcopy and Cervical Pathology (ASCCP) Colposcopy Standards recommendations address the role of and approach to colposcopy and biopsy for cervical cancer prevention in the United States. The recommendations were developed by an expert working group appointed by ASCCP's Board of Directors. The ASCCP Quality Improvement Working Group developed evidence-based guidelines to promote best practices and reduce errors in colposcopy and recommended indicators to measure colposcopy quality...
October 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28945781/radiogenomics-of-neuroblastomas-relationships-between-imaging-phenotypes-tumor-genomic-profile-and-survival
#17
Hervé J Brisse, Thomas Blanc, Gudrun Schleiermacher, Véronique Mosseri, Pascale Philippe-Chomette, Isabelle Janoueix-Lerosey, Gaelle Pierron, Eve Lapouble, Michel Peuchmaur, Paul Fréneaux, Louise Galmiche, Nathalie Algret, Matthieu Peycelon, Jean Michon, Olivier Delattre, Sabine Sarnacki
PURPOSE: This study investigated relationships between neuroblastomas (NBs) imaging phenotypes, tumor genomic profile and patient outcome. PATIENTS AND METHODS: This IRB-approved retrospective observational study included 133 NB patients (73 M, 60 F; median age 15 months, range 0-151) treated in a single institution between 1998 and 2012. A consensus review of imaging (CT-scan, MRI) categorized tumors according to both the primarily involved compartment (i.e., neck, chest, abdomen or pelvis) and the sympathetic anatomical structure the tumors rose from (i...
2017: PloS One
https://www.readbyqxmd.com/read/28941657/effects-of-a-complex-rehabilitation-program-on-edema-status-physical-function-and-quality-of-life-in-lower-limb-lymphedema-after-gynecological-cancer-surgery
#18
Jung Hwa Do, Kyoung Hyo Choi, Jun Su Ahn, Jae Yong Jeon
OBJECTIVE: The purpose of this study was to investigate the effects of a complex rehabilitation (CR) program and complex decongestive therapy (CDT) on edema status, physical function, and quality of life in patients with unilateral lower-limb lymphedema after gynecologic cancer surgery. METHODS: In this randomized pilot study, 40 patients with secondary unilateral lymphedema, after gynecologic surgery for cervical, endometrial, or ovarian cancer, that had been diagnosed based on clinical assessment and 10% volume differences between the legs were randomly assigned to the CDT (n=20) and CDT combined with CR (CRCDT; n=20) groups...
September 20, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28940520/direction-modulated-brachytherapy-dmbt-for-treatment-of-cervical-cancer-a-planning-study-with-192ir-60co-and-169yb-hdr-sources
#19
Habib Safigholi, Dae Yup Han, Shahram Mashouf, Abraam Soliman, Ali S Meigooni, Amir Owrangi, William Y Song
PURPOSE: To evaluate plan quality of a novel MRI-compatible direction modulated brachytherapy (DMBT) tandem applicator using 192Ir, 60Co, and 169Yb HDR brachytherapy sources, for various cervical cancer high-risk clinical target volumes (CTVHR ). MATERIALS AND METHODS: The novel DMBT tandem applicator has six peripheral grooves of 1.3-mm diameter along a 5.4-mm thick nonmagnetic tungsten alloy rod. Monte Carlo (MC) simulations were used to benchmark the dosimetric parameters of the 192Ir, 60Co, and 169Yb HDR sources in a water phantom against the literature data...
September 22, 2017: Medical Physics
https://www.readbyqxmd.com/read/28939180/what-is-the-optimal-number-of-library-plans-in-art-for-locally-advanced-cervical-cancer
#20
E Nováková, S T Heijkoop, S Quint, A G Zolnay, J W M Mens, J Godart, B J M Heijmen, M S Hoogeman
PURPOSE: Library-of-plans ART is used to manage daily anatomy changes in locally advanced cervical cancer. In our institute, the library contains 2 VMAT plans for patients with large cervix-uterus motion. Increasing this number could be beneficial for tissue sparing, but is burdensome while the dosimetric gain is yet unclear. This study's aim is to determine the optimal number of plans at an individual patient level. MATERIAL AND METHODS: Data of 14 treated patients were analyzed...
September 19, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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