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https://www.readbyqxmd.com/read/29466264/effects-of-high-sound-exposure-during-air-conducted-vestibular-evoked-myogenic-potential-testing-in-children-and-young-adults
#1
Amanda I Rodriguez, Megan L A Thomas, Denis Fitzpatrick, Kristen L Janky
OBJECTIVES: Vestibular evoked myogenic potential (VEMP) testing is increasingly utilized in pediatric vestibular evaluations due to its diagnostic capability to identify otolith dysfunction and feasibility of testing. However, there is evidence demonstrating that the high-intensity stimulation level required to elicit a reliable VEMP response causes acoustic trauma in adults. Despite utility of VEMP testing in children, similar findings are unknown. It is hypothesized that increased sound exposure may exist in children because differences in ear-canal volume (ECV) compared with adults, and the effect of stimulus parameters (e...
March 2018: Ear and Hearing
https://www.readbyqxmd.com/read/29464985/comparison-of-phase-contrast-mr-and-flow-simulations-for-the-study-of-csf-dynamics-in-the-cervical-spine
#2
Erika Kristina Lindstrøm, Jakob Schreiner, Geir Andre Ringstad, Victor Haughton, Per Kristian Eide, Kent-Andre Mardal
Background Investigators use phase-contrast magnetic resonance (PC-MR) and computational fluid dynamics (CFD) to assess cerebrospinal fluid dynamics. We compared qualitative and quantitative results from the two methods. Methods Four volunteers were imaged with a heavily T2-weighted volume gradient echo scan of the brain and cervical spine at 3T and with PC-MR. Velocities were calculated from PC-MR for each phase in the cardiac cycle. Mean pressure gradients in the PC-MR acquisition through the cardiac cycle were calculated with the Navier-Stokes equations...
January 1, 2018: Neuroradiology Journal
https://www.readbyqxmd.com/read/29456583/fetal-adrenal-gland-biometry-and-cervical-elastography-as-predictors-of-preterm-birth-a-comparative-study
#3
Shubhra Agarwal, Arjit Agarwal, Pawan Joon, Shalini Saraswat, Shruti Chandak
Background: Preterm birth is a major health problem in developing and developed countries leading to rising health care costs and long-term neurodevelopmental disability. The study aims to evaluate the role of new quantitative markers, like the elastography of cervix (shear wave speed estimation), fetal adrenal zone enlargement, and corrected fetal adrenal gland volume; in preterm birth prediction and analyze their relative importance. Thus, these markers may be beneficial in early preterm birth detection and prevent the related morbidities...
February 2018: Ultrasound: Journal of the British Medical Ultrasound Society
https://www.readbyqxmd.com/read/29454311/radiotherapy-related-skin-toxicity-rarest-01-mepitel%C3%A2-film-versus-standard-care-in-patients-with-locally-advanced-head-and-neck-cancer
#4
Carlos Narvaez, Claudia Doemer, Christian Idel, Cornelia Setter, Denise Olbrich, Zaza Ujmajuridze, Jesper Hansen Carl, Dirk Rades
BACKGROUND: The aim of the present trial is to investigate a new option of skin protection in order to reduce the rate of grade ≥ 2 skin toxicity in patients receiving radiotherapy alone or radiochemotherapy for locally advanced squamous cell carcinoma of the head-and-neck (SCCHN). METHODS / DESIGN: This is a randomized, active-controlled, parallel-group multi-center trial that compares the following treatments of radiation dermatitis in patients with head-and-neck cancer: Mepitel® Film (Arm A) vs...
February 17, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29453893/cbct-guided-evolutive-library-for-cervical-adaptive-imrt
#5
Bastien Rigaud, Antoine Simon, Maxime Gobeli, Caroline Lafond, Julie Leseur, Anais Barateau, Nicolas Jaksic, Joël Castelli, Danièle Williaume, Pascal Haigron, Renaud De Crevoisier
PURPOSE: In the context of adaptive radiation therapy (ART) for locally advanced cervical carcinoma (LACC), this study proposed an original cone-beam computed tomography (CBCT)-guided "Evolutive library" and evaluated it against four other known radiotherapy (RT) strategies. MATERIAL AND METHODS: For 20 patients who underwent intensity-modulated radiation therapy (IMRT) for LACC, three planning CTs (with empty [EB], intermediate [IB], and full [FB] bladder volumes), a CT scan at 20 Gy and bi-weekly CBCTs for 5 weeks were performed...
February 17, 2018: Medical Physics
https://www.readbyqxmd.com/read/29441094/artificial-neural-network-based-gynaecological-image-guided-adaptive-brachytherapy-treatment-planning-correction-of-intra-fractional-organs-at-risk-dose-variation
#6
Ramin Jaberi, Zahra Siavashpour, Mahmoud Reza Aghamiri, Christian Kirisits, Reza Ghaderi
Purpose: Intra-fractional organs at risk (OARs) deformations can lead to dose variation during image-guided adaptive brachytherapy (IGABT). The aim of this study was to modify the final accepted brachytherapy treatment plan to dosimetrically compensate for these intra-fractional organs-applicators position variations and, at the same time, fulfilling the dosimetric criteria. Material and methods: Thirty patients with locally advanced cervical cancer, after external beam radiotherapy (EBRT) of 45-50 Gy over five to six weeks with concomitant weekly chemotherapy, and qualified for intracavitary high-dose-rate (HDR) brachytherapy with tandem-ovoid applicators were selected for this study...
December 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29433177/trabecular-anatomy-of-the-axis-vertebra-a-study-of-shaded-volume-rendered-computed-tomography-images
#7
K Venugopal Menon, Sameer B Raniga
BACKGROUND: To date, trabecular morphology studies have been conducted on thin-section computed tomography (CT) scans of cadaveric bone. Here we describe the trabecular anatomy of the axis vertebra as revealed by an innovative imaging tool. METHODS: Ten patients who underwent thin-slice CT scans for suspected cervical spine injury were prospectively subjected to shaded volume-rendered 3-dimensional reconstruction of the images. The trabecular anatomy thus depicted was recreated, and the mechanical vectors were deduced independently by a senior radiologist and spine surgeon and then matched...
February 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29426746/image-guided-adaptive-brachytherapy-in-primary-vaginal-cancers-a-monocentric-experience
#8
Andres Huertas, Isabelle Dumas, Alexandre Escande, Eleonor Rivin Del Campo, Tony Felefly, Charles-Henri Canova, Anne Tailleur, Sebastien Gouy, Enrica Bentivegna, Philippe Morice, Christine Haie-Meder, Cyrus Chargari, Renaud Mazeron
PURPOSE: Primary vaginal cancer is a rare disease for which treatment has been modeled based on cervical cancer. We report our experience in the use of image-guided adaptive brachytherapy (IGABT) in this indication. METHODS AND MATERIALS: Patients treated for vaginal cancer with a combination of external beam radiation therapy and IGABT were identified through electronic search. The Groupe Européen de Curiethérapie-European Society for Radiotherapy and Oncology recommendations for cervical cancer have been extrapolated with the definition of two clinical target volumes (CTVs) corresponding to the residual disease after external beam radiation therapy (CTVBT ), assessed from clinical and imaging findings, and the so-called CTVi , comprising the CTVBT with directional margins and at least the initial disease at diagnosis...
February 6, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29426744/improving-dose-delivery-by-adding-interstitial-catheters-to-fixed-geometry-applicators-in-high-dose-rate-brachytherapy-for-cervical-cancer
#9
Sophie Otter, Amanda Coates, Adrian Franklin, Melanie Cunningham, Alexandra Stewart
PURPOSE: Image-guided brachytherapy (IGBT) is an essential component of the treatment of locally advanced cervical cancer. Interstitial (IS) catheters are being increasingly used for bulkier tumors. We have retrospectively assessed the dosimetric impact of IS catheters. METHODS AND MATERIALS: All patients who received IGBT for cervical cancer between August 2014 and February 2017 were identified. Clinical and dosimetric data were collected. Patients were grouped into the intracavitary (IC) cohort or the IC and IS implant (IC/IS) cohort...
February 6, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29426638/comparison-of-dosimetric-parameters-derived-from-whole-organ-and-wall-contours-for-bladder-and-rectum-in-cervical-cancer-patients-treated-with-intracavitary-and-interstitial-brachytherapy
#10
Rachel Gerber, Alexandra Rink, Jennifer Croke, Jette Borg, Akbar Beiki-Ardakani, Anthony Fyles, Michael Milosevic, Jason Xie, Harald Keller, Kathy Han
For volumes up to 2 cm3 of the bladder and possibly up to 5 cm3 of the rectum, doses computed from the whole organ were good estimates of the doses in the wall in cervix brachytherapy, and there were no significant differences between patients treated with or without interstitial needles.
February 6, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29413694/anticancer-activity-of-crocin-against-cervical-carcinoma-hela-cells-bioassessment-and-toxicity-evaluation-of-crocin-in-male-albino-rats
#11
Zuiming Jiang, Min Gu, Jiaqiang Liu, Huiyuan Li, Jun Peng, Yuejun Zhang
The present study was aimed to investigate anticancer activity of crocin against cervical carcinoma and bio-assessment and toxicological evaluation in male albino rats. Effect of crocin on cell viability (anticancer activity) was determined against cervical carcinoma cells. Chronic effect of crocin on body weight changes, serum enzymes, serum biochemical markers, lipid peroxidation, hematological markers and DNA damage in male albino rats were determined. Cell survival rate was reduced 98.4, 95.7, 87.2, 81...
January 17, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29407505/role-of-cone-beam-computed-tomography-with-a-large-field-of-view-in-goldenhar-syndrome
#12
Cosimo Nardi, Luisa De Falco, Valeria Selvi, Chiara Lorini, Linda Calistri, Stefano Colagrande
INTRODUCTION: Goldenhar syndrome is a rare disease with hemifacial microsomia and craniofacial disorders originating from the first and second branchial arches, such as ocular, auricular, and vertebral anomalies. The complexity and variety of the ways in which the disease presents itself usually need several examinations. In this study, we aimed to evaluate both craniofacial and vertebral skeletal anomalies and asymmetries between the nonaffected and affected sides in patients with Goldenhar syndrome by using cone-beam computed tomography...
February 2018: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/29404934/biochemical-and-pathologic-factors-affecting-technetium-99m-methoxyisobutylisonitrile-imaging-results-in-patients-with-primary-hyperparathyroidism
#13
Aysenur Ozderya, Sule Temizkan, Aylin Ege Gul, Sule Ozugur, Kenan Cetin, Kadriye Aydin
OBJECTIVE: Technetium 99 m methoxyisobutylisonitrile (Tc-99m MIBI) scintigraphy represents the most commonly utilized imaging modality for the detection of the diseased gland in patients with primary hyperparathyroidism (PHPT). In this study, we aimed to identify potential biological factors with an impact on MIBI sensitivity. METHODS: A total of 147 patients with surgically confirmed parathyroid adenomas were assessed retrospectively. Data including medical history, biochemical and hormonal measurements, cervical US, Tc-99m MIBI scans as well as pathology reports were retrieved and recorded...
February 5, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29388719/multi-compartmental-diffusion-characterization-of-the-human-cervical-spinal-cord-in-vivo-using-the-spherical-mean-technique
#14
Samantha By, Junzhong Xu, Bailey A Box, Francesca R Bagnato, Seth A Smith
The purpose of this work was to evaluate the feasibility and reproducibility of the spherical mean technique (SMT), a multi-compartmental diffusion model, in the spinal cord of healthy controls, and to assess its ability to improve spinal cord characterization in multiple sclerosis (MS) patients at 3 T. SMT was applied in the cervical spinal cord of eight controls and six relapsing-remitting MS patients. SMT provides an elegant framework to model the apparent axonal volume fraction vax , intrinsic diffusivity Dax , and extra-axonal transverse diffusivity Dex_perp (which is estimated as a function of vax and Dax ) without confounds related to complex fiber orientation distribution that reside in diffusion MRI modeling...
February 1, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29383502/influences-of-different-lower-cervical-bone-graft-heights-on-the-size-of-the-intervertebral-foramen-multiple-planar-dynamic-measurements-with-laser-scanning
#15
Rui Yang, Mengjun Ma, Lin Huang, Jichao Ye, Yong Tang, Peng Wang, Dezhen Yin, Keng Chen, Weiping Li, Huiyong Shen
The aim of this study is to evaluate the influences of different bone graft heights on the size of the intervertebral foramen, which will help determine the optimal graft height in clinical practice. Six fresh adult cadavers were used, with the C5-C6 vertebral column segment defined as the functional spinal unit (FSU). After discectomy, the C5/6 intervertebral height was set as the baseline height (normal disc height). We initially used spiral computed tomography (CT) to scan and measure the middle area of the intervertebral foramen when at the baseline height...
January 30, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29379040/mri-of-the-cervical-spinal-cord-predicts-respiratory-dysfunction-in-als
#16
G Grolez, M Kyheng, R Lopes, C Moreau, K Timmerman, F Auger, G Kuchcinski, A Duhamel, P Jissendi-Tchofo, P Besson, C Laloux, M Petrault, J C Devedjian, Thierry Pérez, Pierre François Pradat, L Defebvre, R Bordet, V Danel-Brunaud, D Devos
For patients with amyotrophic lateral sclerosis (ALS), the primary therapeutic goal is to minimize morbidity. Non-invasive ventilation improves survival. We aim to assess whether Magnetic Resonance Imaging (MRI) of the cervical spinal cord predicts the progression of respiratory disorders in ALS. Brain and spinal MRI was repeatedly performed in the SOD1G86R mouse model, in 40 patients and in healthy controls. Atrophy, iron overload, white matter diffusivity and neuronal loss were assessed. In Superoxide Dismutase-1 (SOD1) mice, iron accumulation appeared in the cervical spinal cord at symptom onset but disappeared with disease progression (after the onset of atrophy)...
January 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29378024/impact-of-a-commercially-available-model-based-dose-calculation-algorithm-on-treatment-planning-of-high-dose-rate-brachytherapy-in-patients-with-cervical-cancer
#17
Kota Abe, Noriyuki Kadoya, Shinya Sato, Shimpei Hashimoto, Yujiro Nakajima, Yuya Miyasaka, Kengo Ito, Rei Umezawa, Takaya Yamamoto, Noriyoshi Takahashi, Ken Takeda, Keiichi Jingu
We evaluated the impact of model-based dose calculation algorithms (MBDCAs) on high-dose-rate brachytherapy (HDR-BT) treatment planning for patients with cervical cancer. Seven patients with cervical cancer treated using HDR-BT were studied. Tandem and ovoid applicators were used in four patients, a vaginal cylinder in one, and interstitial needles in the remaining two patients. MBDCAs were applied to the Advanced Collapsed cone Engine (ACE; Elekta, Stockholm, Sweden). All plans, which were originally calculated using TG-43, were re-calculated using both ACE and Monte Carlo (MC) simulations...
January 25, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/29374458/unique-depot-formed-by-an-oil-based-vaccine-facilitates-active-antigen-uptake-and-provides-effective-tumour-control
#18
Kimberly D Brewer, Genevieve M Weir, Iulia Dude, Christa Davis, Cathryn Parsons, Andrea Penwell, Rajkannan Rajagopalan, Leeladhar Sammatur, Chris V Bowen, Marianne M Stanford
BACKGROUND: Oil emulsions are commonly used as vaccine delivery platforms to facilitate slow release of antigen by forming a depot at the injection site. Antigen is trapped in the aqueous phase and as the emulsion degrades in vivo the antigen is passively released. DepoVax™ is a unique oil based delivery system that directly suspends the vaccine components in the oil diluent that forces immune cells to actively take up components from the formulation in the absence of passive release...
January 27, 2018: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29373821/pharyngeal-airway-space-changes-after-condylar-replacement-and-mandibular-advancement-surgery
#19
Holly Yuen, P Emile Rossouw, Larry M Wolford, Hongyue Wang
PURPOSE: The aim of this study was to examine the total volume and cross-sectional areas of the pharyngeal airway after bilateral condylar replacement and mandibular advancement surgery. MATERIALS AND METHODS: A total of 137 patients (126 women and 11 men) underwent bilateral temporomandibular joint total joint replacement performed by 1 surgeon. A subsample of 30 patients who underwent condylar replacement and only mandibular advancement were evaluated for impact on the airway...
January 3, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29372290/patient-positioning-in-head-and-neck-cancer-setup-variations-and-safety-margins-in-helical-tomotherapy
#20
Christina Leitzen, Timo Wilhelm-Buchstab, Thomas Müdder, Martina Heimann, David Koch, Christopher Schmeel, Birgit Simon, Sabina Stumpf, Susanne Vornholt, Stephan Garbe, Fred Röhner, Felix Schoroth, Hans Heinz Schild, Heinrich Schüller
OBJECTIVE: To evaluate the interfractional variations of patient positioning during intensity-modulated radiotherapy (IMRT) with helical tomotherapy in head and neck cancer and to calculate the required safety margins (sm) for bony landmarks resulting from the necessary table adjustments. MATERIALS AND METHODS: In all, 15 patients with head and neck cancer were irradiated using the Hi-Art II tomotherapy system between April and September 2016. Before therapy sessions, patient position was frequently checked by megavolt computed tomography (MV-CT)...
January 25, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
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