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https://www.readbyqxmd.com/read/29667008/eco-friendly-synthesis-in-vitro-anti-proliferative-evaluation-and-3d-qsar-analysis-of-a-novel-series-of-monocationic-2-aryl-heteroaryl-substituted-6-2-imidazolinyl-benzothiazole-mesylates
#1
Livio Racané, Lucija Ptiček, Mirela Sedić, Petra Grbčić, Sandra Kraljević Pavelić, Branimir Bertoša, Irena Sović, Grace Karminski-Zamola
Herein, we describe the synthesis of twenty-one novel water-soluble monocationic 2-aryl/heteroaryl-substituted 6-(2-imidazolinyl)benzothiazole mesylates 3a-3u and present the results of their anti-proliferative assays. Efficient syntheses were achieved by three complementary simple two-step synthetic protocols based on the condensation reaction of aryl/heteroaryl carbaldehydes or carboxylic acid. We developed an eco-friendly synthetic protocol using glycerol as green solvent, particularly appropriate for the condensation of thermally and acid-sensitive heterocycles such as furan, benzofuran, pyrrole, and indole...
April 17, 2018: Molecular Diversity
https://www.readbyqxmd.com/read/29661053/differential-diagnosis-of-sinonasal-lymphoma-and-squamous-cell-carcinoma-on-ct-mri-and-pet-ct
#2
Seok-Hyun Kim, Sue-Jean Mun, Hak-Jin Kim, Seon Lin Kim, Sung-Dong Kim, Kyu-Sup Cho
Objective The purpose of this study was to analyze computed tomography (CT) and magnetic resonance (MR) images and to evaluate the maximum standardized uptake value (SUV max) of positron emission tomography (PET)/CT parameters between sinonasal non-Hodgkin's lymphoma (NHL) and squamous cell carcinoma (SCC), knowing the imaging features that distinguish sinonasal NHL from SCC. Study Design Case series with chart review. Setting University tertiary care facility. Subjects and Methods We analyzed the features on CT, MR imaging, and PET/CT of 78 patients diagnosed with sinonasal NHL or SCC histopathologically...
April 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29653187/mid-cervical-spinal-cord-contusion-causes-robust-deficits-in-respiratory-parameters-and-pattern-variability
#3
Philippa M Warren, Cara Campanaro, Frank J Jacono, Warren J Alilain
Mid-cervical spinal cord contusion disrupts both the pathways and motoneurons vital to the activity of inspiratory muscles. The present study was designed to determine if a rat contusion model could result in a measurable deficit to both ventilatory and respiratory motor function under "normal" breathing conditions at acute to chronic stages post trauma. Through whole body plethysmography and electromyography we assessed respiratory output from three days to twelve weeks after a cervical level 3 (C3) contusion...
April 10, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29652827/a-dual-bioconjugated-virus-like-nanoparticle-as-a-drug-delivery-system-and-comparison-with-a-ph-responsive-delivery-system
#4
Roya Biabanikhankahdani, Kok Lian Ho, Noorjahan Banu Alitheen, Wen Siang Tan
Modifications of virus-like nanoparticles (VLNPs) using chemical conjugation techniques have brought the field of virology closer to nanotechnology. The huge surface area to volume ratio of VLNPs permits multiple copies of a targeting ligand and drugs to be attached per nanoparticle. By exploring the chemistry of truncated hepatitis B core antigen (tHBcAg) VLNPs, doxorubicin (DOX) was coupled covalently to the external surface of these nanoparticles via carboxylate groups. About 1600 DOX molecules were conjugated on each tHBcAg VLNP...
April 13, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29650390/-18-f-fdg-pet-ct-parameters-to-predict-survival-and-recurrence-in-patients-with-locally-advanced-cervical-cancer-treated-with-chemoradiotherapy
#5
N Scher, J Castelli, A Depeursinge, J Bourhis, J O Prior, F G Herrera, M Ozsahin
PURPOSE: To identify predictive (18 F)-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT)-based parameters for locoregional control, disease-free survival and overall survival, by testing different thresholds of metabolic tumor volume and total lesion glycolysis in patients with locally-advanced cervical cancer. PATIENTS AND METHODS: Thirty-seven patients treated with standard chemoirradiation underwent a pretreatment (18 F)-FDG-PET/CT...
April 9, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29649650/assessment-of-myelopathy-in-cervical-ossification-of-the-posterior-longitudinal-ligament-by-mri-assisted-3d-measurement
#6
Zhiwei Wang, Yanqing Sun, Yifan Tang, Bo Yuan, Shengyuan Zhou, Xiongsheng Chen, Lianshun Jia
OBJECTIVE: Ossification of the posterior longitudinal ligament (OPLL) is a three-dimensional (3D) disease that causes cervical myelopathy. The conventional two-dimensional(2D) measurement of OPLL has limitations in estimating cord-compression and myelopathy. In this study, we attempted to use three-dimensional computed tomography(3D CT) and magnetic resonance imaging(MRI) to measure the 3D occupying ratio of OPLL and investigate its significance in assessment of spinal cord myelopathy...
April 9, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29649085/tract-specific-volume-loss-on-3t-mri-in-patients-with-cervical-spondylotic-myelopathy
#7
Benjamin S Hopkins, Kenneth A Weber, Michael Brendan Cloney, Monica Paliwal, Todd B Parrish, Zachary A Smith
STUDY DESIGN: Case-control. OBJECTIVE: The aim of this study was to understand the role of high-resolution magnetic resonance (MR) in identifying regional cord volume loss in cervical spondylotic myelopathy (CSM). SUMMARY OF BACKGROUND DATA: Preliminary studies suggest that compression of the ventral region of the cord may contribute disproportionately to CSM symptomology; however, tract-specific data are lacking in the CSM population. The current study is the first to use 3T MR imaging (MRI) images of CSM patients to determine specific volume loss at the level of detail of individual descending white matter tracts...
April 11, 2018: Spine
https://www.readbyqxmd.com/read/29649032/airway-management-practice-in-adults-with-an-unstable-cervical-spine-the-harborview-medical-center-experience
#8
Michael G Holmes, Armagan Dagal, Bryan A Feinstein, Aaron M Joffe
BACKGROUND: Airway management in the presence of acute cervical spine injury (CSI) is challenging. Because it limits cervical spine motion during tracheal intubation and allows for neurological examination after the procedure, awake fiberoptic bronchoscopy (FOB) has traditionally been recommended. However, with the widespread availability of video laryngoscopy (VL), its use has declined dramatically. Our aim was to describe the frequency of airway management techniques used in patients with CSI at our level I trauma center and report the incidence of neurological injury attributable to airway management...
April 11, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29648581/multiple-sclerosis-lesions-affect-intrinsic-functional-connectivity-of-the-spinal-cord
#9
Benjamin N Conrad, Robert L Barry, Baxter P Rogers, Satoshi Maki, Arabinda Mishra, Saakshi Thukral, Subramaniam Sriram, Aashim Bhatia, Siddharama Pawate, John C Gore, Seth A Smith
Patients with multiple sclerosis present with focal lesions throughout the spinal cord. There is a clinical need for non-invasive measurements of spinal cord activity and functional organization in multiple sclerosis, given the cord's critical role in the disease. Recent reports of spontaneous blood oxygenation level-dependent fluctuations in the spinal cord using functional MRI suggest that, like the brain, cord activity at rest is organized into distinct, synchronized functional networks among grey matter regions, likely related to motor and sensory systems...
April 10, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29630033/a-randomized-comparison-between-interscalene-and-small-volume-supraclavicular-blocks-for-arthroscopic-shoulder-surgery
#10
Julián Aliste, Daniela Bravo, Diego Fernández, Sebastián Layera, Roderick J Finlayson, De Q Tran
BACKGROUND AND OBJECTIVES: This randomized trial compared ultrasound (US)-guided interscalene block (ISB) and small-volume supraclavicular block (SCB) for arthroscopic shoulder surgery. We hypothesized that SCB would provide equivalent analgesia to ISB 30 minutes after surgery without the risk of hemidiaphragmatic paralysis (HDP). METHODS: All patients received an US-guided intermediate cervical plexus block. In the ISB group, US-guided ISB was performed with 20 mL of levobupivacaine 0...
April 6, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29630020/disparities-in-adherence-to-national-comprehensive-cancer-network-treatment-guidelines-and-survival-for-stage-ib-iia-cervical-cancer-in-california
#11
Krista S Pfaendler, Jenny Chang, Argyrios Ziogas, Robert E Bristow, Kristine R Penner
OBJECTIVE: To evaluate the association of sociodemographic and hospital characteristics with adherence to National Comprehensive Cancer Network treatment guidelines for stage IB-IIA cervical cancer and to analyze the relationship between adherent care and survival. METHODS: This is a retrospective population-based cohort study of patients with stage IB-IIA invasive cervical cancer reported to the California Cancer Registry from January 1, 1995, through December 31, 2009...
April 6, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29628630/interfraction-variations-in-organ-filling-and-their-impact-on-dosimetry-in-ct-image-based-hdr-intracavitary-brachytherapy
#12
Ramya Rangarajan
Aim: Since anatomical and geometric variations occur with every fraction, planning, and dose optimization is necessary for every fraction of high-dose rate intracavitary brachytherapy of carcinoma cervix. In this study, we have tried to quantify the differences in doses to organs at risk (OAR) for each fraction of brachytherapy. Methods and Materials: One hundred and seventy computed tomography datasets of cervical cancer patients receiving intracavitary brachytherapy at our institution between January and April 2015 were analyzed...
January 2018: Journal of Medical Physics
https://www.readbyqxmd.com/read/29625309/risk-factors-for-significant-intraoperative-blood-loss-during-unilateral-expansive-open-door-cervical-laminoplasty-for-cervical-compressive-myelopathy
#13
Yang Meng, Xiaofei Wang, Hua Chen, Ying Hong, Tingkui Wu, Beiyu Wang, Yuxiao Deng, Hao Liu
OBJECTIVE: Unilateral expansive open-door cervical laminoplasty is an effective and safe procedure for cervical compressive myelopathy, but occasionally is accompanied with significant intraoperative blood loss (SIBL). The aim of the present study was to elucidate the risk factors for SIBL in patients undergoing cervical laminoplasty for multilevel cervical compressive myelopathy, and to identify the effect of SIBL on neurological complication. METHODS: A total of 215 patients who received cervical laminoplasty between January 2010 and August 2016 were enrolled in the study...
April 3, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29625077/optimising-the-collection-of-female-genital-tract-fluid-for-cytokine-analysis-in-pregnant-women
#14
C S Short, R Quinlan, P Bennett, R J Shattock, G P Taylor
INTRODUCTION: To better understand the immunology of pregnancy, study of female genital tract fluid (FGF) is desirable. However the optimum method of collection of FGF in pregnant women for immunological methods, specifically cytokine measurement, is unknown. METHODS: A prospective study of HIV-uninfected pregnant women comparing two methods of FGF collection: polyvinyl acetal sponge collection of cervical fluid (CF) and menstrual cup collection of cervicovaginal fluid (CVF)...
April 3, 2018: Journal of Immunological Methods
https://www.readbyqxmd.com/read/29619966/long-term-outcomes-and-prognostic-factors-after-pencil-beam-scanning-proton-radiation-therapy-for-spinal-chordomas-a-large-single-institution-cohort
#15
James W Snider, Ralf A Schneider, Davey Poelma-Tap, Sonja Stieb, Fritz R Murray, Lorenzo Placidi, Francesca Albertini, Antony Lomax, Alessandra Bolsi, Ulrike Kliebsch, Robert Malyapa, Damien C Weber
PURPOSE: To evaluate the efficacy and safety of high-dose pencil-beam scanning proton therapy (PBS-PT) in the adjuvant treatment of spinal chordomas. METHODS AND MATERIALS: Between 1997 and 2015, 100 patients with spinal chordomas (median age, 56 years; range, 25-81 years) were treated with adjuvant PBS-PT at the Paul Scherrer Institute: cervical (n = 46), thoracic (n = 4), lumbar (n = 12), and sacral (n = 38). The majority (88%) received PBS-PT alone rather than combined photon-proton therapy...
May 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29619054/clinical-analysis-of-speculum-based-vaginal-packing-for-high-dose-rate-intracavitary-tandem-and-ovoid-brachytherapy-in-cervical-cancer
#16
Shivani Sud, Toni Roth, Ellen Jones
Purpose: Intra-vaginal packing is used to fix the applicator and displace organs at risk (OAR) during high-dose-rate intracavitary tandem and ovoid brachytherapy (HDR-ICB). We retain the speculum from applicator placement as a dual-function bladder and rectum retractor during treatment. Our objective is to review salient techniques for OAR displacement, share our packing technique, and determine the reduction in dose to OAR and inter-fraction variability of dose to OAR, associated with speculum-based vaginal packing (SBVP) in comparison to conventional gauze packing during HDR-ICB...
February 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29619052/impact-of-brachytherapy-technique-2d-versus-3d-on-outcome-following-radiotherapy-of-cervical-cancer
#17
Kris Derks, Jacco L G Steenhuijsen, Hetty A van den Berg, Saskia Houterman, Jeltsje Cnossen, Paul van Haaren, Katrien De Jaeger
Purpose: The purpose of this study was to analyze the effect of 2D conventional brachytherapy (CBT) compared to 3D MRI-guided brachytherapy (IGBT) with and without the use of interstitial needles on local control, overall survival, and toxicity in patients treated for cervical cancer with radiation or chemoradiation. Material and methods: A retrospective analysis was performed of biopsy-proven FIGO IB-IVA cervical cancer patients, treated with primary radiation or chemoradiation, followed by brachytherapy (BT) between January 1997 and July 2016...
February 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29618353/efficacy-of-virtual-block-objects-in-reducing-the-lung-dose-in-helical-tomotherapy-planning-for-cervical-oesophageal-cancer-a-planning-study
#18
Makoto Ito, Hidetoshi Shimizu, Takahiro Aoyama, Hiroyuki Tachibana, Natsuo Tomita, Chiyoko Makita, Yutaro Koide, Daiki Kato, Tsuneo Ishiguchi, Takeshi Kodaira
BACKGROUND: Intensity-modulated radiotherapy is useful for cervical oesophageal carcinoma (CEC); however, increasing low-dose exposure to the lung may lead to radiation pneumonitis. Nevertheless, an irradiation technique that avoids the lungs has never been examined due to the high difficulty of dose optimization. In this study, we examined the efficacy of helical tomotherapy that can restrict beamlets passing virtual blocks during dose optimization computing (block plan) in reducing the lung dose...
April 4, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29610941/pilot-in-vitro-and-in-vivo-study-on-a-mouse-model-to-evaluate-the-safety-of-transcutaneous-low-frequency-electrical-nerve-stimulation-on-cervical-cancer-patients
#19
Shiyan Wang, Xiuli Sun, Wenjin Cheng, Jue Zhang, Jianliu Wang
INTRODUCTION AND HYPOTHESIS: To clarify whether the pulse electrical field (PEF) caused by transcutaneous low-frequency nerve electrical stimulation (TENS) enhances the proliferation of cervical cancer cells, leading to recurrence and metastasis, and the effect of such a PEF on a cervical cancer mouse model. METHODS: 1. In vitro experiment: SiHa cervical cancer cells treated with one session of microsecond PEFs for 30 min were divided into four groups: three experimental groups and the control group...
April 2, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29607491/increased-single-balloon-foley-catheter-volume-for-induction-of-labor-and-time-to-delivery-a-systematic-review-and-meta-analysis
#20
Corina N Schoen, Gabriele Saccone, Sami Backley, Evelien M Sandberg, Ning Gu, Shani Delaney, Vincenzo Berghella
INTRODUCTION: Induction of labor is a common intervention. The objective was to investigate whether larger Foley catheter volumes for labor induction decrease the total time from induction to delivery. MATERIAL AND METHODS: Randomized controlled trials comparing larger single-balloon volumes (60-80 mL) during Foley catheter cervical ripening with usual volume (30 mL) in women undergoing labor induction were identified by searching electronic databases (MEDLINE, Scopus, ClinicalTrials...
April 1, 2018: Acta Obstetricia et Gynecologica Scandinavica
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