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https://www.readbyqxmd.com/read/28725290/the-discovery-of-the-flammer-syndrome-a-historical-and-personal-perspective
#1
REVIEW
Josef Flammer, Katarzyna Konieczka
This review describes the clinical and basic research that led to the description of Flammer syndrome. It is narrated from a personal perspective. This research was initiated by the observation of an increased long-term fluctuation of visual fields in a subgroup of glaucoma patients. As these patients had strikingly cold hands, peripheral blood flow was tested with a capillary microscopy, and vasospastic syndrome (VS) was diagnosed. Further studies on these patients revealed frequently weakened autoregulation of ocular blood flow and increased flow resistivity in retroocular vessels...
June 2017: EPMA Journal
https://www.readbyqxmd.com/read/28722815/influence-of-morphine-and-naloxone-on-pain-modulation-in-rheumatoid-arthritis-chronic-fatigue-syndrome-fibromyalgia-and-controls-a-double-blind-randomized-placebo-controlled-cross-over-study
#2
Linda Hermans, Jo Nijs, Patrick Calders, Luc De Clerck, Greta Moorkens, Guy Hans, Sofie Grosemans, Tine Roman De Mettelinge, Joanna Tuynman, Mira Meeus
BACKGROUND: Impaired pain inhibitory and enhanced pain facilitatory mechanisms are repeatedly reported in patients with central sensitization pain. However, the exact effects of frequently prescribed opioids on central pain modulation are still unknown. METHODS: A randomized, double-blind, placebo-controlled cross-over trial was carried out. Ten CFS/FM patients, 11 RA patients and 20 controls were randomly allocated to the experimental (10 mg morphine or 0.2 mg/ml Naloxone) and placebo (2 ml Aqua) group...
July 19, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28720713/sensory-processing-of-deep-tissue-nociception-in-the-rat-spinal-cord-and-thalamic-ventrobasal-complex
#3
Shafaq Sikandar, Steven J West, Stephen B McMahon, David L Bennett, Anthony H Dickenson
Sensory processing of deep somatic tissue constitutes an important component of the nociceptive system, yet associated central processing pathways remain poorly understood. Here, we provide a novel electrophysiological characterization and immunohistochemical analysis of neural activation in the lateral spinal nucleus (LSN). These neurons show evoked activity to deep, but not cutaneous, stimulation. The evoked responses of neurons in the LSN can be sensitized to somatosensory stimulation following intramuscular hypertonic saline, an acute model of muscle pain, suggesting this is an important spinal relay site for the processing of deep tissue nociceptive inputs...
July 2017: Physiological Reports
https://www.readbyqxmd.com/read/28701286/association-of-chronic-hepatitis-b-infection-with-metabolic-syndrome-and-its-components-meta-analysis-of-observational-studies
#4
REVIEW
Bahman Razi, Shahab Alizadeh, Azadeh Omidkhoda, Danyal Imani, Ramazan Rezaei
INTRODUCTION: Observational studies evaluating the association between chronic hepatitis B (CHB) and risk of metabolic syndrome (MetS) have yielded inconclusive results. OBJECTIVE: The current meta-analysis was conducted to identify whether CHB infection plays a role in the risk of MetS and its components. METHODS: The electronic search of MEDLINE, PubMed Central, and EMBASE databases was systematically performed from their inception until February 2017 to identify all eligible studies...
July 3, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28694674/mechanisms-of-chronic-pain-key-considerations-for-appropriate-physical-therapy-management
#5
Carol A Courtney, César Fernández-de-Las-Peñas, Samantha Bond
In last decades, knowledge of nociceptive pain mechanisms has expanded rapidly. The use of quantitative sensory testing has provided evidence that peripheral and central sensitization mechanisms play a relevant role in localized and widespread chronic pain syndromes. In fact, almost any patient suffering with a chronic pain condition will demonstrate impairments in the central nervous system. In addition, it is accepted that pain is associated with different types of trigger factors including social, physiological, and psychological...
July 2017: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/28690234/-pcdh19-gene-mutations-lead-to-epilepsy-with-mental-retardation-limited-to-females-in-2-cases-and-literature-review
#6
Li Yang, Ahmed Arafat, Jing Peng, Chen Chen, Yuping Ma, Fei Yin
Epilepsy with mental retardation limited to females (EFMR) is a syndrome characterized by early onset heat-sensitive epilepsy of infancy or early childhood and generally limited to females, which previously reported that the cadherin gene superfamily subtype protocadherin 19 (PCDH19) gene is its pathogenic gene. We retrospectively analyzed the clinical data for 2 cases of EFMR patients with PCDH19 mutation diagnosed by Department of Pediatric Neurology of Xiangya Hospital, Central South University in 2015. Literature on PubMed, OMIM and HGMD relevant to this syndrome was reviewed, and the clinical characteristics were summarized accordingly...
June 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28685627/hyperacusis-in-chronic-pain-neural-interactions-between-the-auditory-and-nociceptive-systems
#7
Aries P Suhnan, Philip M Finch, Peter D Drummond
OBJECTIVE: Sensory disturbances are common in chronic pain patients. Hyperacusis can be an especially debilitating experience. Here, we review published work on how the auditory and nociceptive systems might interact in chronic pain syndromes to produce pain-hyperacusis. DESIGN: Literature review. STUDY SAMPLE: The PubMed and Scopus databases were searched for relevant articles published between 2000 and 2017 using the primary search terms "hyperacusis"/"hyperacousis" and "pain"...
July 7, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28683025/visceral-pain-as-a-triggering-factor-for-fibromyalgia-symptoms-in-comorbid-patients
#8
Raffaele Costantini, Giannapia Affaitati, Ursula Wesselmann, Peter Czakanski, Maria Adele Giamberardino
Fibromyalgia (FMS) is a central sensitization syndrome, however peripheral pain sources potentially exacerbate its symptoms of chronic diffuse musculoskeletal pain and hyperalgesia. This prospective study evaluated visceral pain as a possible triggering factor for FMS pain/hyperalgesia in comorbid patients. Women with: a) FMS+irritable bowel syndrome (IBS); b) FMS+primary dysmenorrhea (Dys); c) FMS+dysmenorrhea secondary to endometriosis (Endo); d) FMS+colon diverticulosis (Div) were compared with FMS-only women, for fibromyalgia pain (number/intensity of episodes, analgesic consumption) over comparable time periods and for somatic hyperalgesia (electrical/pressure pain thresholds) in painful (Tender Points, TePs) and control areas (trapezius, deltoid, quadriceps muscles and overlying subcutis and skin)...
July 3, 2017: Pain
https://www.readbyqxmd.com/read/28681949/age-stratified-thresholds-of-anti-m%C3%A3-llerian-hormone-improve-prediction-of-polycystic-ovary-syndrome-over-a-population-based-threshold
#9
Molly M Quinn, Chia-Ning Kao, Asima K Ahmad, Daniel J Haisenleder, Nanette Santoro, Esther Eisenberg, Richard S Legro, Marcelle I Cedars, Heather G Huddleston
OBJECTIVE: Due to its consistent elevation in polycystic ovary syndrome (PCOS) and correlation with polycystic ovarian morphology (PCOM), anti-Mullerian hormone (AMH) has been proposed as a marker of the syndrome. However, prior studies reporting thresholds of AMH for a PCOS diagnosis have been limited by small sample size, inappropriate controls, and heterogeneous AMH assays. We sought to evaluate the suitability of a standardized AMH assay as a biomarker of PCOS. DESIGN: Cross-sectional study at academic medical centers across the United States...
July 6, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28681628/the-management-of-fibromyalgia-from-a-psychosomatic-perspective-an-overview
#10
Federica Sancassiani, Sergio Machado, Valeria Ruggiero, Enrico Cacace, Claudia Carmassi, Camilla Gesi, Liliana Dell'Osso, Mauro Giovanni Carta
Fibromyalgia (FM) is a central sensitization syndrome characterized by chronic widespread pain. FM is often comorbid with psychiatric disorders, as well as psychological distress that worsens the quality-of-life of people affected. The aim was to collect current evidence about the management of FM from a psychosomatic perspective. The literature was synthesized and summarized in a narrative format. The literature search was carried out in PubMed; review articles, meta-analysis, overview, and guidelines published in the last 10 years written in English were included...
July 6, 2017: International Review of Psychiatry
https://www.readbyqxmd.com/read/28628232/sensory-mapping-of-pelvic-dermatomes-in-women-with-interstitial-cystitis-bladder-pain-syndrome
#11
Tatiana Sanses, Patrick McCabe, Ling Zhong, Aisha Taylor, Gisela Chelimsky, Sangeeta Mahajan, Tony Buffington, Adonis Hijaz, Sarah Ialacci, Jeffrey Janata, Thomas Chelimsky
AIM: To describe a sensory map of pelvic dermatomes in women with Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS). We hypothesized that if IC/BPS involves changes in central processing, then women with IC/BPS will exhibit sensory abnormalities in neurologic pelvic dermatomes. METHODS: Women with IC/BPS and healthy controls underwent neurologic examination that included evaluation of sharp pain sensitivity and vibration in dermatomes T12, L1, L2, S1-5. Peripheral nervous system sensitivity to pressure, vibration, and pinprick were scored using numeric rating scales (NRS)...
June 19, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28626863/prolactin-correction-for-adequacy-of-petrosal-sinus-cannulation-may-diminish-diagnostic-accuracy-in-cushing-s-disease
#12
Sunita Mc De Sousa, Ann I McCormack, Shaun McGrath, David J Torpy
OBJECTIVE: Petrosal venous prolactin concentrations have been promoted to improve the diagnostic accuracy of inferior petrosal sinus sampling (IPSS), beyond that achieved with ACTH measurement alone, in diagnosing a pituitary ACTH source, and determining corticotrophinoma side (L/R). Our objective was to assess the effect of using prolactin to confirm adequacy of petrosal cannulation in a cohort of patients with ACTH-dependent Cushing's syndrome. DESIGN: Retrospective cohort study...
June 19, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28619687/use-of-the-central-sensitization-inventory-csi-as-a-treatment-outcome-measure-for-chronic-spinal-pain-disorder-patients-in-a-functional-restoration-program
#13
Randy Neblett, Meredith M Hartzell, Mark Williams, Kelley R Bevers, Tom G Mayer, Robert J Gatchel
BACKGROUND CONTEXT: The Central Sensitization Inventory (CSI) is a valid and reliable patient-reported instrument designed to identify patients whose presenting symptoms may be related to Central Sensitization (CS). Part A of the CSI measures a full array of 25 somatic and emotional symptoms associated with CS, and Part B asks if patients have previously been diagnosed with one or more specific Central Sensitivity Syndromes (CSSs) and related disorders. The CSI has previously been validated in a group of chronic pain patients who were screened by a trained psychiatrist for specific CSS diagnoses...
June 12, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28615901/varicella-zoster-virus-infection-of-the-central-nervous-system-10-year-experience-from-a-tertiary-hospital-in-south-india
#14
Ronald Albert Benton Carey, Vignesh Kumar Chandiraseharan, Anitha Jasper, Tunny Sebastian, Chrusolitha Gujjarlamudi, Sowmya Sathyendra, Anand Zachariah, Asha Mary Abraham, Thambu David Sudarsanam
INTRODUCTION: Varicella zoster virus is an exclusively human neurotrophic virus. The primary infection with the virus causes varicella. The virus remains latent in nervous tissue and upon secondary activation causes a variety of syndromes involving the central nervous system (CNS) including meningoencephalitis and cerebellitis. MATERIALS AND METHODS: In this study, we looked at the epidemiology, clinical and laboratory features, and outcomes of patients who were admitted with varicella zoster of the CNS from 2005 to 2014...
April 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28608686/targeted-metabolic-profiling-of-post-mortem-brain-from-infants-who-died-from-sudden-infant-death-syndrome
#15
Stewart F Graham, Onur Turkoglu, Praveen Kumar, Ali Yilmaz, Trent C Bjorndahl, BeomSoo Han, Rupasri Mandal, David S Wishart, Ray O Bahado-Singh
Currently little is known about the underlying pathophysiology associated with SIDS, and no objective biomarkers exist for the accurate identification of those at greatest risk of dying from SIDS. Using targeted metabolomics, we aim to profile the medulla oblongata of infants who have died from SIDS (n = 16) and directly compare their biochemical profile with age matched controls. Combining data acquired using (1)H NMR and targeted DI-LC-MS/MS, we have identified fatty acid oxidation as a pivotal biochemical pathway perturbed in the brains of those infants who have from SIDS (p = 0...
June 20, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28597079/men1-mutations-and-potentially-men1-targeting-mirnas-are-responsible-for-menin-deficiency-in-sporadic-and-men1-syndrome-associated-primary-hyperparathyroidism
#16
Vince Kornél Grolmusz, Katalin Borka, Annamária Kövesdi, Kinga Németh, Katalin Balogh, Csaba Dékány, András Kiss, Anna Szentpéteri, Beatrix Sármán, Anikó Somogyi, Éva Csajbók, Zsuzsanna Valkusz, Miklós Tóth, Péter Igaz, Károly Rácz, Attila Patócs
Inherited, germline mutations of menin-coding MEN1 gene cause multiple endocrine neoplasia type 1 (MEN1), while somatic MEN1 mutations are the sole main driver mutations in sporadic primary hyperparathyroidism (PHPT), suggesting that menin deficiency has a central role in the pathogenesis of PHPT. MiRNAs are small, noncoding RNAs posttranscriptionally regulating gene expression. Our aim was to investigate both the role of MEN1 mutations and potentially MEN1-targeting miRNAs as the underlying cause of menin deficiency in MEN1-associated and sporadic PHPT tissues...
June 8, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28585193/the-definition-and-prevalence-of-obesity-and-metabolic-syndrome
#17
Atilla Engin
Increase in prevalence of obesity has become a worldwide major health problem in adults, as well as among children and adolescents. Furthermore, total adiposity and truncal subcutaneous fat accumulation during adolescence are positively and independently associated with atherosclerosis at adult ages. Centrally accumulation of body fat is associated with insulin resistance, whereas distribution of body fat in a peripheral pattern is metabolically less important. Obesity is associated with a large decrease in life expectancy...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28567448/type-i-interferon-responses-drive-intrahepatic-t-cells-to-promote-metabolic-syndrome
#18
Magar Ghazarian, Xavier S Revelo, Mark K Nøhr, Helen Luck, Kejing Zeng, Helena Lei, Sue Tsai, Stephanie A Schroer, Yoo Jin Park, Melissa Hui Yen Chng, Lei Shen, June Ann D'Angelo, Peter Horton, William C Chapman, Diane Brockmeier, Minna Woo, Edgar G Engleman, Oyedele Adeyi, Naoto Hirano, Tianru Jin, Adam J Gehring, Shawn Winer, Daniel A Winer
Obesity-related insulin resistance is driven by low-grade chronic inflammation of metabolic tissues. In the liver, non-alcoholic fatty liver disease (NAFLD) is associated with hepatic insulin resistance and systemic glucose dysregulation. However, the immunological factors supporting these processes are poorly understood. We found that the liver accumulates pathogenic CD8+ T cell subsets which control hepatic insulin sensitivity and gluconeogenesis during diet-induced obesity in mice. In a cohort of human patients, CD8+ T cells represent a dominant intrahepatic immune cell population which links to glucose dysregulation...
April 21, 2017: Science Immunology
https://www.readbyqxmd.com/read/28536900/hopes-for-the-future-of-pain-control
#19
REVIEW
Kirsty Bannister, Mateusz Kucharczyk, Anthony H Dickenson
Here we aim to present an accessible review of the pharmacological targets for pain management, and succinctly discuss the newest trends in pain therapy. A key task for current pain pharmacotherapy is the identification of receptors and channels orchestrating nociception. Notwithstanding peripheral alterations in the receptors and channels following pathophysiological events, the modulatory mechanisms in the central nervous system are also fundamental to the regulation of pain perception. Bridging preclinical and clinical studies of peripheral and central components of pain modulation, we present the different types of pain and relate these to pharmacological interventions...
May 23, 2017: Pain and Therapy
https://www.readbyqxmd.com/read/28535557/endogenous-pain-facilitation-rather-than-inhibition-differs-between-people-with-chronic-fatigue-syndrome-multiple-sclerosis-and-controls-an-observational-study
#20
Simon M Collin, Jo Nijs, Mira Meeus, Andrea Polli, Barbara Willekens, Kelly Ickmans
BACKGROUND: Commonalities in the core symptoms of fatigue and cognitive dysfunction experienced by chronic fatigue syndrome (CFS, also known as ME) and multiple sclerosis (MS) patients have been described. Many CFS and MS patients also experience chronic pain, which has been attributed to central sensitization in both groups of patients. However, the characteristics of pain in CFS and MS patients have not been compared. OBJECTIVES: To compare experimental pain measurements in patients with CFS or MS and healthy controls...
May 2017: Pain Physician
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