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central sensitivity syndromes

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https://www.readbyqxmd.com/read/28535557/endogenous-pain-facilitation-rather-than-inhibition-differs-between-people-with-chronic-fatigue-syndrome-multiple-sclerosis-and-controls-an-observational-study
#1
Simon M Collin, Jo Nijs, Mira Meeus, Andrea Polli, Barbara Willekens, Kelly Ickmans
BACKGROUND: Commonalities in the core symptoms of fatigue and cognitive dysfunction experienced by chronic fatigue syndrome (CFS, also known as ME) and multiple sclerosis (MS) patients have been described. Many CFS and MS patients also experience chronic pain, which has been attributed to central sensitization in both groups of patients. However, the characteristics of pain in CFS and MS patients have not been compared. OBJECTIVES: To compare experimental pain measurements in patients with CFS or MS and healthy controls...
May 2017: Pain Physician
https://www.readbyqxmd.com/read/28516431/a-comparison-of-neuroimaging-abnormalities-in-multiple-sclerosis-major-depression-and-chronic-fatigue-syndrome-myalgic-encephalomyelitis-is-there-a-common-cause
#2
REVIEW
Gerwyn Morris, Michael Berk, Basant K Puri
There is copious evidence of abnormalities in resting-state functional network connectivity states, grey and white matter pathology and impaired cerebral perfusion in patients afforded a diagnosis of multiple sclerosis, major depression or chronic fatigue syndrome (CFS) (myalgic encephalomyelitis). Systemic inflammation may well be a major element explaining such findings. Inter-patient and inter-illness variations in neuroimaging findings may arise at least in part from regional genetic, epigenetic and environmental variations in the functions of microglia and astrocytes...
May 17, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28505202/serum-hbv-surface-antigen-positivity-is-associated-with-low-prevalence-of-metabolic-syndrome-a-meta-analysis
#3
Yuanyuan Li, Ying Zhao, Jianping Wu
BACKGROUND AND AIM: As there is conflicting evidence for the relationship between hepatitis B virus surface antigen (HBsAg) positivity and the prevalence of metabolic syndrome (MetS), we performed a meta-analysis to investigate whether HBsAg positivity affects the incidence of MetS. METHODS: Observational studies on the relationship between HBsAg positivity and MetS were obtained from PubMed, Web of Science, and the Cochrane Library in April 2016. The pooled odds ratios (ORs) of MetS and its components (central obesity, increased fasting glucose, increased blood pressure, dyslipidemia) for subjects with or without HBsAg positivity were synthesized...
2017: PloS One
https://www.readbyqxmd.com/read/28492219/kappa-free-light-chains-in-cerebrospinal-fluid-of-patients-with-identified-oligoclonal-immunoglobulin-g
#4
Marina Vasilj, Miro Klarić, Nada Vrkić, Ivanka Mikulić, Marijana Marković Boras, Nevenka Jelić-Knezović, Violeta Šoljić
BACKGROUND: Production of kappa free light chains (KFLC) represents a part of humoral immune response, along with the synthesis of intrathecal immunoglobulins. Increased concentrations of immunoglobulin G light chains, kappa and lambda chains, were identified through research of numerous diseases of central nervous system. The qualitative method of isoelectric focusing (IEF) followed by immunofixation currently represents the accepted standard in identifying oligoclonal bands (OCB), but establishing a sensitive immunonephelometric method for quantification of kappa free light chains (KFLC) in cerebrospinal fluid (CSF) has paved a way for new diagnostic possibilities...
May 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28481836/sensitivity-of-the-dn4-in-screening-for-neuropathic-pain-syndromes
#5
Elizabeth G VanDenKerkhof, Larry Stitt, Alexander J Clark, Allan Gordon, Mary Lynch, Patricia K Morley-Forster, Howard J Nathan, Catherine Smyth, Cory Toth, Mark A Ware, Dwight E Moulin
OBJECTIVES: Several tools have been developed to screen for neuropathic pain. This study examined the sensitivity of the Douleur Neuropathique en 4 Questions (DN4) in screening for various neuropathic pain syndromes. METHODS: This prospective observational study was conducted in 7 Canadian academic pain centers between April 2008 and December 2011. All newly admitted patients (n=2199) were approached and 789 eligible participants form the sample for this analysis...
May 5, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28479809/mild-encephalitis-with-a-reversible-splenial-lesion-a-clinical-benign-condition-often-underrecognized-clinical-case-and-literature-review
#6
Sandro Zambito Marsala, Eleonora Antichi, Michele Pistacchi, Manuela Gioulis, Rosa Maria Candeago, Roberta Taranto Montemurro, Manrico Gentile, Paolo D'Andrea, Franco Ferracci
Mild encephalitis with reversible lesion in the splenium is a clinicoradiological syndrome characterized by a variegated symptomatology with a solitary mass in the central portion of the splenium of the corpus callosum. Complete spontaneous resolution is the hallmark of this syndrome, though its pathogenesis is still unknown. We describe the clinical picture of a 51-year-old woman who developed a partial sensitive seizure, with MRI evidence of a lesion localized in the posterior portion of the corpus callosum...
April 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28449376/psychological-distress-and-widespread-pain-contribute-to-the-variance-of-the-central-sensitization-inventory-a-cross-sectional-study-in-patients-with-chronic-pain
#7
C P van Wilgen, P J Vuijk, J Kregel, L Voogt, M Meeus, F Descheemaker, D Keizer, J Nijs
OBJECTIVES: Central sensitization (CS) implies increased sensitivity of the nervous system, resulting in increased pain sensitivity as well as widespread pain. Recently, the Central Sensitization Inventory (CSI) was developed to assess symptoms of CS and central sensitivity syndromes. The aim of this study was to examine the convergent validity of the CSI by comparing the outcome to psychosocial factors and clinical features of CS. METHODS: In a cross-sectional explorative study, patients with chronic pain completed multiple questionnaires, including the CSI, pain catastrophizing scale, SCL-90 for psychological distress, duration of pain, intensity of pain, widespread pain, and lateralization of pain...
April 27, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28431243/cryo-em-structure-of-the-open-human-ether-%C3%A3-go-go-related-k-channel-herg
#8
Weiwei Wang, Roderick MacKinnon
The human ether-à-go-go-related potassium channel (hERG, Kv11.1) is a voltage-dependent channel known for its role in repolarizing the cardiac action potential. hERG alteration by mutation or pharmacological inhibition produces Long QT syndrome and the lethal cardiac arrhythmia torsade de pointes. We have determined the molecular structure of hERG to 3.8 Å using cryo-electron microscopy. In this structure, the voltage sensors adopt a depolarized conformation, and the pore is open. The central cavity has an atypically small central volume surrounded by four deep hydrophobic pockets, which may explain hERG's unusual sensitivity to many drugs...
April 20, 2017: Cell
https://www.readbyqxmd.com/read/28424823/-coma-in-the-emergency-room
#9
M Braun, C J Ploner, T Lindner, M Möckel, W U Schmidt
Coma of unknown origin (CUO) is a frequent unspecific emergency symptom associated with a high mortality. A fast diagnostic work-up is essential given the wide spectrum of underlying diagnoses that are made up of approximately 50% primary central nervous system (CNS) pathologies and approximately 50% extracerebral, almost exclusively internal medical causes. Despite the high mortality associated with this symptom, there are currently no generally accepted management guidelines for adult patients presenting with CUO...
April 19, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28424788/fully-automated-robust-system-to-detect-retinal-edema-central-serous-chorioretinopathy-and-age-related-macular-degeneration-from-optical-coherence-tomography-images
#10
Samina Khalid, M Usman Akram, Taimur Hassan, Ammara Nasim, Amina Jameel
Maculopathy is the excessive damage to macula that leads to blindness. It mostly occurs due to retinal edema (RE), central serous chorioretinopathy (CSCR), or age related macular degeneration (ARMD). Optical coherence tomography (OCT) imaging is the latest eye testing technique that can detect these syndromes in early stages. Many researchers have used OCT images to detect retinal abnormalities. However, to the best of our knowledge, no research that presents a fully automated system to detect all of these macular syndromes is reported...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28422829/impact-of-pain-on-cognitive-functions-in-primary-sj%C3%A3-gren-syndrome-with-small-fiber-neuropathy-10-cases-and-a-literature-review
#11
REVIEW
Sandrine Indart, Jacques Hugon, Pierre Jean Guillausseau, Alice Gilbert, Julien Dumurgier, Claire Paquet, Damien Sène
Primary Sjögren syndrome (pSS) is a chronic systemic autoimmune disease characterized by xerophthalmia, xerostomia, and potential peripheral or central neurological involvement. In pSS, the prevalence of cognitive disorders is generally sparse across literature and the impact of pain on cognitive profile is unclear. The aim of this study was to determine the relation between pain, cognitive complaint, and impairment in a very homogenous population of 10 pSS patients with painful small fiber neuropathy (PSFN) and spontaneous cognitive complaint...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28421037/lipid-processing-in-the-brain-a-key-regulator-of-systemic-metabolism
#12
REVIEW
Kimberley D Bruce, Andrea Zsombok, Robert H Eckel
Metabolic disorders, particularly aberrations in lipid homeostasis, such as obesity, type 2 diabetes mellitus, and hypertriglyceridemia often manifest together as the metabolic syndrome (MetS). Despite major advances in our understanding of the pathogenesis of these disorders, the prevalence of the MetS continues to rise. It is becoming increasingly apparent that intermediary metabolism within the central nervous system is a major contributor to the regulation of systemic metabolism. In particular, lipid metabolism within the brain is tightly regulated to maintain neuronal structure and function and may signal nutrient status to modulate metabolism in key peripheral tissues such as the liver...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28413474/obesity-contributes-more-to-increasing-apob-apoa1-ratio-than-hyperandrogenism-in-pcos-women-aged-20-38-years-in-china
#13
Jianhua Zheng, Qianqian Yin, Juanyi Cao, Bei Zhang
We investigated the association between the apolipoprotein B (ApoB)/apolipoprotein A1 (ApoA1) ratio and insulin resistance (IR), metabolic syndrome (MS) and its components in Chinese polycystic ovary syndrome (PCOS) adults. We also examined whether hyperandrogenism is involved in obesity-related metabolic abnormalities in a cohort of patients. A clinical cross-sectional study consisting of 532 Chinese PCOS adults aged 20-38 years was designed. Each subject underwent a physical examination and laboratory evaluation...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28412164/diagnosis-and-management-of-oropharyngeal-dysphagia-among-older-persons-state-of-the-art
#14
REVIEW
Omar Ortega, Alberto Martín, Pere Clavé
Oropharyngeal dysphagia (OD) is a condition recognized by the World Health Organization and defined as the difficulty or inability to move a bolus safely and effectively from the oral cavity to the esophagus, and can include aspirations, choking, and residue. OD is pandemic among different phenotypes of older people, affecting between 27% and 91% of the population 70 years or older. Although OD can be diagnosed by well-defined clinical methods and complementary explorations, in the clinical setting OD is seldom systematically screened and treated, and awareness among the medical/geriatric community is scarce...
April 12, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28409494/association-between-metabolically-healthy-central-obesity-in-women-and-levels-of-soluble-receptor-for-advanced-glycation-end-products-soluble-vascular-adhesion-protein-1-and-the-activity-of-semicarbazide-sensitive-amine-oxidase
#15
Ivana Koborová, Radana Gurecká, Melinda Csongová, Katarína Volkovová, Éva Szökő, Tamás Tábi, Katarína Šebeková
AIM: To determine the levels of circulating soluble receptor for advanced glycation end products (sRAGE), as a biomarker of risk of metabolic syndrome and cardiovascular disease development in centrally obese (CO) women considered metabolically healthy (COH) in comparison with those metabolically unhealthy (COU). METHODS: 47 lean healthy, 17 COH (presenting waist-to-height ratio ≥0.5 but not elevated blood pressure, atherogenic lipid profile, and insulin resistance), and 50 COU (CO presenting ≥2 risk factors) women aged 40-45 years were included...
April 14, 2017: Croatian Medical Journal
https://www.readbyqxmd.com/read/28399161/seroprevalence-of-severe-fever-with-thrombocytopenia-syndrome-virus-in-china-a-systematic-review-and-meta-analysis
#16
Peng Li, Zhen-Dong Tong, Ke-Feng Li, An Tang, Ya-Xin Dai, Jian-Bo Yan
OBJECTIVE: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel bunyavirus-SFTSV. The seroprevalence of anti-SFTSV antibodies including immunoglobulin G (IgG) and immunoglobulin M (IgM), specific to SFTSV in the general population has been investigated in various epidemiological studies with inconsistent results. Here, we clarify this discrepancy and reach a more comprehensive result by mean of a meta-analysis. METHODS: All relevant articles were searched in the electronic databases (PubMed, Web of science, Embase, Chinese National Knowledge Infrastructure database, Chinese Wanfang database) up to November 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28394145/increased-startle-potentiation-to-unpredictable-stressors-in-alcohol-dependence-possible-stress-neuroadaptation-in-humans
#17
Christine A Moberg, Daniel E Bradford, Jesse T Kaye, John J Curtin
Stress plays a key role in addiction etiology and relapse. Rodent models posit that following repeated periods of alcohol and other drug intoxication, compensatory allostatic changes occur in the central nervous system (CNS) circuits involved in behavioral and emotional response to stressors. We examine a predicted manifestation of this neuroadaptation in recently abstinent alcohol-dependent humans. Participants completed a translational laboratory task that uses startle potentiation to unpredictable (vs. predictable) stressors implicated in the putative CNS mechanisms that mediate this neuroadaptation...
May 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/28379567/retinal-photoreceptor-functions-are-compromised-in-patients-with-resistance-to-thyroid-hormone-syndrome-rth%C3%AE
#18
Irene Campi, Gabriella Cammarata, Stefania Bianchi Marzoli, Paolo Beck-Peccoz, Diletta Santarsiero, Davide Dazzi, Alessandra Bottari de Castello, Elena Giuliana Taroni, Francesco Viola, Caterina Mian, Sara Watuntantrige-Fernando, Carla Pelusi, Marina Muzza, Maria Antonia Maffini, Luca Persani
CONTEXT: In animal models, disruption of thyroid hormone receptor-beta (TRβ) reduces the medium-wavelength (L/M) and increases the short-wavelength (S)-cones. The retinal photoreceptors (RPs) functions are unknown in patients with resistance to thyroid hormone syndrome with dominant-negative TRβ mutations (RTHβ). OBJECTIVE: to investigate RPs function in RTHβ. DESIGN, SETTING AND PARTICIPANTS: case-control study involving 27 RTHβ patients and 31 age-gender-matched controls, conducted in two tertiary referral centers in Italy...
March 31, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28376513/the-role-of-environmental-stress-on-lower-urinary-tract-symptoms
#19
Melissa T Sanford, Larissa V Rodriguez
PURPOSE OF REVIEW: Lower urinary tract symptoms (LUTS) have been associated with comorbid conditions such as anxiety and depression. In addition, stress appears to influence the development or exacerbation of LUTS. This article seeks to review literature regarding the role of environmental stress on LUTS, focusing on findings presented in the last year. RECENT FINDINGS: Numerous authors have published on the impact early childhood experiences, acute and chronic stress, and psychiatric illness play in the development of LUTS...
May 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28373658/nod2-and-nod2-regulated-microbiota-protect-balb-c-mice-from-diet-induced-obesity-and-metabolic-dysfunction
#20
Ivan Rodriguez-Nunez, Tiffany Caluag, Kori Kirby, Charles N Rudick, Roman Dziarski, Dipika Gupta
Genetics plays a central role in susceptibility to obesity and metabolic diseases. BALB/c mice are known to be resistant to high fat diet (HFD)-induced obesity, however the genetic cause remains unknown. We report that deletion of the innate immunity antibacterial gene Nod2 abolishes this resistance, as Nod2 (-/-) BALB/c mice developed HFD-dependent obesity and hallmark features of metabolic syndrome. Nod2 (-/-) HFD mice developed hyperlipidemia, hyperglycemia, glucose intolerance, increased adiposity, and steatosis, with large lipid droplets in their hepatocytes...
April 3, 2017: Scientific Reports
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