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https://www.readbyqxmd.com/read/29763608/early-prognostic-factors-of-outcomes-in-monochorionic-twin-pregnancy-systematic-review-and-meta-analysis
#1
REVIEW
Fiona L Mackie, Matthew J Hall, R Katie Morris, Mark D Kilby
OBJECTIVE: Assess ability of first trimester pregnancy related factors (ultrasound measurements, maternal characteristics, biomarkers) to predict complications in monochorionic twin pregnancies DATA SOURCES: MEDLINE, EMBASE, ISI Web of Science, CINAHL, the Cochrane Central Registration of Controlled Trials and Research Registers, and Google Scholar, from inception to 12 May 2017. Grey literature and bibliographies of articles were checked. STUDY ELIGIBILITY CRITERIA: Studies that reported ultrasound measurements, maternal characteristics, or potential biomarkers, measured in the first trimester in monochorionic diamniotic twin pregnancies, where the potential prognostic ability between the variable and twin-twin transfusion syndrome, growth restriction, or intrauterine fetal death could be assessed...
May 12, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29763369/adipose-y5r-mrna-is-higher-in-obese-than-non-obese-humans-and-is-correlated-with-obesity-parameters
#2
Saimai Chatree, Chantacha Sitticharoon, Pailin Maikaew, Panapat Uawithya, Supornpim Chearskul
Neuropeptide Y is mainly expressed in the central nervous system to regulate food intake via its receptors, Y receptors, and in various peripheral tissues including adipose tissue. The objectives of this study were to compare Y5R mRNA and adipocyte parameters consisting of area, width, height, and perimeter either between obese and non-obese subjects or between subcutaneous and visceral fat as well as to compare between NPY, Y1R, Y2R, and Y5R mRNA expressions in subcutaneous and visceral adipose tissues. In subcutaneous and visceral adipose tissues, Y5R was greater in obese than in non-obese humans (both P < 0...
May 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29762873/l-ornithine-l-aspartate-for-prevention-and-treatment-of-hepatic-encephalopathy-in-people-with-cirrhosis
#3
REVIEW
Ee Teng Goh, Caroline S Stokes, Sandeep S Sidhu, Hendrik Vilstrup, Lise Lotte Gluud, Marsha Y Morgan
BACKGROUND: Hepatic encephalopathy is a common complication of cirrhosis and has high associated morbidity and mortality. The condition is classified as overt if it is clinically apparent or minimal if only evident though psychometric testing. The exact pathogenesis of this syndrome is unknown although ammonia is thought to play a key role. L-ornithine L-aspartate has ammonia-lowering properties and may, therefore, benefit people with cirrhosis and hepatic encephalopathy. OBJECTIVES: To evaluate the beneficial and harmful effects of L-ornithine L-aspartate versus placebo, no intervention, or other active interventions in people with cirrhosis and hepatic encephalopathy...
May 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29750060/fascial-preadipocytes-another-missing-piece-of-the-puzzle-to-understand-fibromyalgia
#4
Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Francesca Cavallaro, David Lintonbon
Fibromyalgia (FM) syndrome is a chronic condition causing pain, affecting approximately 0.5%-6% of the developed countries' population, and on average, 2% of the worldwide population. Despite the large amount of scientific literature available, the FM etiology is still uncertain. The diagnosis is based on the clinical presentation and the severity of the symptomatology. Several studies pointed out pathological alterations within the central nervous system, suggesting that FM could originate from a central sensitization of the pain processing centers...
2018: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/29747089/effects-of-high-intensity-interval-training-on-optic-nerve-head-and-macular-perfusion-using-optical-coherence-tomography-angiography-in-healthy-adults
#5
Boris Schmitz, Pieter Nelis, Florian Rolfes, Maged Alnawaiseh, Andreas Klose, Michael Krüger, Nicole Eter, Stefan-Martin Brand, Florian Alten
BACKGROUND AND AIMS: High-intensity interval training (HIIT) has been identified to be efficient for increasing health-related fitness in general and in lifestyle-induced chronic diseases such as hypertension, obesity and metabolic syndrome. This study aimed to evaluate HIIT effects on optic nerve head (ONH) and macular perfusion in healthy adults using optical coherence tomography angiography (OCTA). METHODS: Fifty-eight healthy participants (22.0 ± 2.02 years, 40 females (69...
April 26, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29746512/visual-acuity-and-contrast-sensitivity-are-two-important-factors-affecting-vision-related-quality-of-life-in-advanced-age-related-macular-degeneration
#6
Miin Roh, Alexandra Selivanova, Hyun Joon Shin, Joan W Miller, Mary Lou Jackson
PURPOSE: Vision loss from age-related macular degeneration (AMD) has a profound effect on vision-related quality of life (VRQoL). The pupose of this study is to identify clinical factors associated with VRQoL using the Rasch- calibrated NEI VFQ-25 scales in bilateral advanced AMD patients. METHODS: We retrospectively reviewed 47 patients (mean age 83.2 years) with bilateral advanced AMD. Clinical assessment included age, gender, type of AMD, high contrast visual acuity (VA), history of medical conditions, contrast sensitivity (CS), central visual field loss, report of Charles Bonnet Syndrome, current treatment for AMD and Rasch-calibrated NEI VFQ-25 visual function and socioemotional function scales...
2018: PloS One
https://www.readbyqxmd.com/read/29742297/advances-in-cellular-and-integrative-control-of-oxygen-homeostasis-within-the-central-nervous-system
#7
Jan-Marino Ramirez, Liza Severs, Sanja C Ramirez, Ibis M Agosto-Marlin
Mammals must continuously regulate the levels of O2 and CO2 , which is particularly important for the brain. Failure to maintain adequate O2 /CO2 homeostasis has been associated with numerous disorders including sleep apnea, Rett syndrome, and sudden infant death syndrome (SIDS). But, O2 /CO2 homeostasis poses major regulatory challenges, even in the healthy brain. Neuronal activities change in a differentiated, spatially and temporally complex manner, which is reflected in equally complex changes in O2 demand...
May 9, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29724743/efficacy-of-bilevel-positive-airway-pressure-and-continuous-positive-airway-pressure-therapy-in-patients-with-obesity-hypoventilation-syndrome-protocol-for-systematic-review-and-meta-analysis
#8
Lili Guan, Weiliang Wu, Yating Huo, Xiaoying Li, Bingpeng Guo, Yuqiong Yang, Jiawen Xu, Fangfang Jiang, Luqian Zhou, Rongchang Chen
INTRODUCTION: Obesity hypoventilation syndrome (OHS) is a major respiratory complication caused by severe obesity, being associated with significant morbidity, negative impacts on quality of life and reduced survival if not treated appropriately. Positive airway pressure therapy is the first-line treatment for OHS although the optimal modality remains unclear. The goal of this study is to identify the efficacy of home bilevel positive airway pressure therapy by comparison to continuous positive airway pressure therapy and determine the best strategy for patients with OHS...
May 3, 2018: BMJ Open
https://www.readbyqxmd.com/read/29716734/the-difficulties-of-pseudo-cushing-s-syndrome-or-non-neoplastic-hypercortisolism
#9
Olivier Chabre
Pseudo-Cushing's syndrome covers different pathological conditions responsible for mild-to-moderate ACTH-dependent hypercortisolism, related not to an ACTH-secreting tumor but rather to CRH and/or AVP hypothalamic secretion through activation of various neural pathways, in patients generally displaying excess central adiposity. It is better termed "non-neoplastic hypercortisolism" (NNH). The main conditions implicated in NNH comprise: neuropsychiatric disorder, alcohol abuse, insulin-resistant obesity, polycystic ovary syndrome, and end-stage kidney disease...
April 28, 2018: Annales D'endocrinologie
https://www.readbyqxmd.com/read/29706432/increased-risk-of-ischemic-stroke-associated-with-new-onset-atrial-fibrillation-complicating-acute-coronary-syndrome-a-systematic-review-and-meta-analysis
#10
Jiachen Luo, Hongqiang Li, Xiaoming Qin, Baoxin Liu, Jinlong Zhao, Guli Maihe, Zhiqiang Li, Yidong Wei
BACKGROUND: Atrial fibrillation has been established as a major risk factor of ischemic stroke, however, the influence of new-onset atrial fibrillation (NOAF) complicating acute coronary syndrome (ACS) on ischemic stroke remains controversial. This meta-analysis aimed to validate the association between NOAF complicating ACS and ischemic stroke. METHODS: We identified randomized controlled trials and cohort studies comparing the ischemic stroke risk between patients with NOAF and sinus rhythm after ACS by searching MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials databases...
April 23, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29706023/plasma-markers-of-oxidative-status-were-associated-with-increasing-continuous-cardiometabolic-risk-scores-in-healthy-students-aged-16-20-without-central-obesity
#11
I Koborová, R Gurecká, M Csongová, J Šebek, K Šebeková
AIM: We studied the association between increased cardiometabolic risk and markers of oxidative status and glycation in apparently healthy subjects who did not present with central obesity. METHODS: From 2011 to 2012, we recruited 2,064 students (53% girls) aged 16-20 years from Western Slovakia. Their continuous metabolic syndrome scores were calculated as a mean of the sum of the z-scores of waist-to-height ratio, mean arterial pressure, triacylglycerols, high-density lipoproteins cholesterol and quantitative insulin sensitivity check index...
April 29, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29702223/an-integrative-approach-to-investigate-the-association-among-high-sensitive-c-reactive-protein-body-fat-mass-distribution-and-other-cardiometabolic-risk-factors-in-young-healthy-women
#12
Bin Wu, Jingshan Huang, Lihua Zhang, Mohan Vamsi Kasukurthi, Fangwan Huang, Jiang Bian, Keisuke Fukuo, Tsutomu Kazumi
Prior research has indicated that as an important biomarker of chronic low-grade inflammation, high-sensitivity C-reactive protein (hs-CRP) can play important roles on the onset of metabolic syndrome and cardiovascular diseases (CVD). We conducted an integrative approach, which combines biological wet-lab experiments, statistical analysis, and semantics-oriented bioinformatics & computational analysis, to investigate the association among hs-CRP, body fat mass (FM) distribution, and other cardiometabolic risk factors in young healthy women...
April 24, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29686686/autoimmune-lymphoproliferative-syndrome-fas-patients-have-an-abnormal-regulatory-t-cell-treg-phenotype-but-display-normal-natural-treg-suppressive-function-on-t-cell-proliferation
#13
Fabienne Mazerolles, Marie-Claude Stolzenberg, Olivier Pelle, Capucine Picard, Benedicte Neven, Alain Fischer, Aude Magerus-Chatinet, Frederic Rieux-Laucat
Objective: Autoimmune lymphoproliferative syndrome (ALPS) with FAS mutation (ALPS-FAS) is a nonmalignant, noninfectious, lymphoproliferative disease with autoimmunity. Given the central role of natural regulatory T cells (nTregs) in the control of lymphoproliferation and autoimmunity, we assessed nTreg-suppressive function in 16 patients with ALPS-FAS. Results: The proportion of CD25high CD127low Tregs was lower in ALPS-FAS patients than in healthy controls. This subset was correlated with a reduced CD25 expression in CD3+ CD4+ T cells from ALPS patients and thus an abnormally low proportion of CD25high FOXP3+ Helios+ T cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29680436/distal-muscle-activity-alterations-during-the-stance-phase-of-gait-in-restless-leg-syndrome-rls-patients
#14
Chloe Dafkin, Andrew Green, Benita Olivier, Warrick McKinon, Samantha Kerr
OBJECTIVE: To assess if there is a circadian variation in electromyographical (EMG) muscle activity during gait in restless legs syndrome (RLS) patients and healthy control participants. METHODS: Gait assessment was done in 14 RLS patients and 13 healthy control participants in the evening (PM) and the morning (AM). Muscle activity was recorded bilaterally from the tibialis anterior (TA), lateral gastrocnemius (GL), rectus femoris (RF) and biceps femoris (BF) muscles...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29678132/neck-circumference-may-be-a-valuable-tool-for-screening-individuals-with-obesity-findings-from-a-young-chinese-population-and-a-meta-analysis
#15
Xiaoting Pei, Li Liu, Mustapha Umar Imam, Ming Lu, Yanzi Chen, Panpan Sun, Yaxin Guo, Yiping Xu, Zhiguang Ping, Xiaoli Fu
BACKGROUND: Central obesity and overweight/obesity can result in various chronic non-communicable diseases, such as cardiovascular disease, metabolic syndrome, and diabetes mellitus. Waist circumference (WC) and body mass index (BMI) are widely used to measure obesity despite their limitations. For example, WC and BMI cannot be measured in pregnant women and subjects with abdominal ascites or masses. Therefore, this study aims to determine the efficacy of neck circumference (NC) as a tool for screening central obesity and overweight/obesity...
April 20, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29675131/glycine-increases-insulin-sensitivity-and-glutathione-biosynthesis-and-protects-against-oxidative-stress-in-a-model-of-sucrose-induced-insulin-resistance
#16
Mohammed El-Hafidi, Martha Franco, Angélica Ruiz Ramírez, José Santamaria Sosa, José Antonio Pineda Flores, Ocarol López Acosta, Monserrath Chávez Salgado, Guillermo Cardoso-Saldaña
Oxidative stress and redox status play a central role in the link between insulin resistance (IR) and lipotoxicity in metabolic syndrome. This mechanistic link may involve alterations in the glutathione redox state. We examined the effect of glycine supplementation to diet on glutathione biosynthesis, oxidative stress, IR, and insulin cell signaling in liver from sucrose-fed (SF) rats characterized by IR and oxidative stress. Our hypothesis is that the correction of glutathione levels by glycine treatment leads to reduced oxidative stress, a mechanism associated with improved insulin signaling and IR...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29665426/human-papillomavirus-vaccine-and-demyelinating-diseases-a-systematic-review-and-meta-analysis
#17
Julie Mouchet, Francesco Salvo, Emanuel Raschi, Elisabetta Poluzzi, Ippazio Cosimo Antonazzo, Fabrizio De Ponti, Bernard Bégaud
Approved in 2006, human papillomavirus (HPV) vaccines were initially targeted for girls aged 9-14 years. Although the safety of these vaccines has been monitored through post-licensure surveillance programmes, cases of neurological events have been reported worldwide. The present study aimed to assess the risk of developing demyelination after HPV immunization by meta-analysing risk estimates from pharmacoepidemiologic studies. A systematic review was conducted in Medline, Embase, ISI Web of Science and the Cochrane Library from inception to 10 May 2017, without language restriction...
April 14, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29618656/ontogeny-and-reversal-of-brain-circuit-abnormalities-in-a-preclinical-model-of-pcos
#18
Mauro Sb Silva, Melanie Prescott, Rebecca E Campbell
Androgen excess is a hallmark of polycystic ovary syndrome (PCOS), a prevalent yet poorly understood endocrine disorder. Evidence from women and preclinical animal models suggests that elevated perinatal androgens can elicit PCOS onset in adulthood, implying androgen actions in both PCOS ontogeny and adult pathophysiology. Prenatally androgenized (PNA) mice exhibit a robust increase of progesterone-sensitive GABAergic inputs to gonadotropin-releasing hormone (GnRH) neurons implicated in the pathogenesis of PCOS...
April 5, 2018: JCI Insight
https://www.readbyqxmd.com/read/29556959/neurogenic-inflammation-in-fibromyalgia
#19
REVIEW
Geoffrey Littlejohn, Emma Guymer
Fibromyalgia is a high impact chronic pain disorder with a well-defined and robust clinical phenotype. Key features include widespread pain and tenderness, high levels of sleep disturbance, fatigue, cognitive dysfunction and emotional distress. Abnormal processing of pain and other sensory input occurs in the brain, spinal cord and periphery and is related to the processes of central and peripheral sensitization. As such, fibromyalgia is deemed to be one of the central sensitivity syndromes. There is increasing evidence of neurogenically derived inflammatory mechanisms occurring in the peripheral tissues, spinal cord and brain in fibromyalgia...
March 19, 2018: Seminars in Immunopathology
https://www.readbyqxmd.com/read/29543647/painful-neurotrophins-and-their-role-in-visceral-pain
#20
Ana E López-Pérez, Kulmira Nurgali, Raquel Abalo
Beyond their well-known role in embryonic development of the central and peripheral nervous system, neurotrophins, particularly nerve growth factor and brain-derived neurotrophic factor, exert an essential role in pain production and sensitization. This has mainly been studied within the framework of somatic pain, and even antibodies (tanezumab and fasinumab) have recently been developed for their use in chronic somatic painful conditions, such as osteoarthritis or low back pain. However, data suggest that neurotrophins also exert an important role in the occurrence of visceral pain and visceral sensitization...
April 2018: Behavioural Pharmacology
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