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https://www.readbyqxmd.com/read/28915523/-biologic-reconstruction-of-full-sized-cartilage-defects-of-the-hip-a-guideline-from-the-dgou-group-clinical-tissue-regeneration-and-the-hip-committee-of-the-aga
#1
Stefan Fickert, Matthias Aurich, Dirk Albrecht, Peter Angele, Lorenz Büchler, Michael Dienst, Christoph Erggelet, Jürgen Fritz, Christoph Gebhart, Hans Gollwitzer, Moritz Kindler, Christoph Lampert, Henning Madry, Gregor Möckel, Phillip Niemeyer, Jörg Schröder, Christian Sobau, Gunter Spahn, Wolfgang Zinser, Stefan Landgraeber
Background Symptomatic pre-arthritic deformities such as femoroacetabular impingement (FAI) or hip dysplasia often lead to localised cartilage defects and subsequently to osteoarthritis. The present review of the working group "Clinical Tissue Regeneration" of the German Society of Orthopaedics and Trauma (DGOU) and the hip committee of the AGA (German speaking Society for Arthroscopy and Joint Surgery) provides an overview of current knowledge of the diagnosis and surgical treatment of cartilage defects, in order to infer appropriate therapy recommendations for the hip...
September 15, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28895646/transfusion-approaches-and-mortality-in-trauma-patients-a-narrative-review
#2
Dietmar Fries, Petra Innerhofer, Donat R Spahn
No abstract text is available yet for this article.
September 11, 2017: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/28869567/using-next-generation-sequencing-to-identify-and-quantify-the-genetic-composition-of-resistance-breaking-commercial-isolates-of-cydia-pomonella-granulovirus
#3
Gianpiero Gueli Alletti, Annette J Sauer, Birgit Weihrauch, Eva Fritsch, Karin Undorf-Spahn, Jörg T Wennmann, Johannes A Jehle
The use of Cydia pomonella granulovirus (CpGV) isolates as biological control agents of codling moth (CM) larvae is important in organic and integrated pome fruit production worldwide. The commercially available isolates CpGV-0006, CpGV-R5, and CpGV-V15 have been selected for the control of CpGV resistant CM populations in Europe. In infection experiments, CpGV-0006 and CpGV-R5 were able to break type I resistance and to a lower extent also type III resistance, whereas CpGV-V15 overcame type I and the rarely occurring type II and type III resistance...
September 4, 2017: Viruses
https://www.readbyqxmd.com/read/28842890/sequential-super-resolution-imaging-of-bacterial-regulatory-proteins-the-nucleoid-and-the-cell-membrane-in-single-fixed-e-coli-cells
#4
Christoph Spahn, Mathilda Glaesmann, Yunfeng Gao, Yong Hwee Foo, Marko Lampe, Linda J Kenney, Mike Heilemann
Despite their small size and the lack of compartmentalization, bacteria exhibit a striking degree of cellular organization, both in time and space. During the last decade, a group of new microscopy techniques emerged, termed super-resolution microscopy or nanoscopy, which facilitate visualizing the organization of proteins in bacteria at the nanoscale. Single-molecule localization microscopy (SMLM) is especially well suited to reveal a wide range of new information regarding protein organization, interaction, and dynamics in single bacterial cells...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28763361/dexmedetomidine-associated-hyperthermia-a-series-of-9-cases-and-a-review-of-the-literature
#5
Bernard D Krüger, Judith Kurmann, Natascia Corti, Donat R Spahn, Dominique Bettex, Alain Rudiger
Dexmedetomidine, an α2-adrenergic agonist, can be used to perform mild to moderate sedation in critically ill patients. In this case series, 9 cardiovascular intensive care unit patients with hyperthermia during dexmedetomidine administration, suggestive of drug fever, are presented. Hyperthermia (>38.5°C) occurred 6 (4-10) hours (median [interquartile range]) after dexmedetomidine initiation at a dose of 1.0 (0.8-1.3) μg/kg/h and was resolved 3 (1-8) hours after discontinuation of dexmedetomidine. All patients were screened for infectious and noninfectious causes of hyperthermia, and the findings were analyzed by 2 adverse drug reaction (ADR) assessment methods-the World Health Organization-Uppsala Monitoring Centre (WHO-UMC) Causality Assessment and the Naranjo ADR scale...
July 28, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28753838/the-empact-classifier-a-validated-tool-to-predict-postoperative-prostate-cancer-related-death-using-competing-risk-analysis
#6
Lorenzo Tosco, Annouschka Laenen, Alberto Briganti, Paolo Gontero, R Jeffrey Karnes, Patrick J Bastian, Piotr Chlosta, Frank Claessens, Felix K Chun, Wouter Everaerts, Christian Gratzke, Maarten Albersen, Markus Graefen, Burkhard Kneitz, Giansilvio Marchioro, Rafael Sanchez Salas, Bertrand Tombal, Thomas Van den Broeck, Henk Van Der Poel, Jochen Walz, Gert De Meerleer, Alberto Bossi, Karin Haustermans, Hendrik Van Poppel, Martin Spahn, Steven Joniau
BACKGROUND: Accurate prediction of survival after radical prostatectomy (RP) is important for making decisions regarding multimodal therapies. There is a lack of tools to predict prostate cancer-related death (PCRD) in patients with high-risk features. OBJECTIVE: To develop and validate a prognostic model that predicts PCRD combining pathologic features and using competing-risks analysis. DESIGN, SETTING, AND PARTICIPANTS: This was a retrospective multi-institutional observational cohort study of 5876 patients affected by high-risk prostate cancer...
January 17, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28707777/pain-assessment-discrepancies-a-cross-sectional-study-highlights-the-amount-of-underrated-pain
#7
Andrea van Ransbeeck, Ana Budilivski, Donat R Spahn, Lucian Macrea, Francesca Giuliani, Konrad Maurer
BACKGROUND: Inadequately treated postoperative pain can lead to longer healing processes, longer hospital stays and the development of chronic pain. In a 900-bed university hospital in Switzerland pain scores were assessed systematically. The study's primary aim was to define whether the routine pain assessment on the ward is accurate and reproducible. Subsequently the obtained data were used for a benchmark analysis to determine the hospitals performance in pain assessment quality compared with similar centers...
July 14, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28684008/ribosomal-chamber-music-toward-an-understanding-of-ires-mechanisms
#8
REVIEW
Hiroshi Yamamoto, Anett Unbehaun, Christian M T Spahn
Internal initiation is a 5'-end-independent mode of translation initiation engaged by many virus- and putatively some cell-encoded templates. Internal initiation is facilitated by specific RNA tertiary folds, called internal ribosomal entry sites (IRESs), in the 5' untranslated region (UTR) of the respective transcripts. In this review we discuss recent structural insight into how established IRESs first capture and then manipulate the eukaryotic translation machinery through non-canonical interactions and by guiding the intrinsic conformational flexibility of the eukaryotic ribosome...
July 3, 2017: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/28673386/polyglycerol-opioid-conjugate-produces-analgesia-devoid-of-side-effects
#9
Sara González-Rodríguez, Mohiuddin A Quadir, Shilpi Gupta, Karolina A Walker, Xuejiao Zhang, Viola Spahn, Dominika Labuz, Antonio Rodriguez-Gaztelumendi, Martin Schmelz, Jan Joseph, Maria K Parr, Halina Machelska, Rainer Haag, Christoph Stein
Novel painkillers are urgently needed. The activation of opioid receptors in peripheral inflamed tissue can reduce pain without central adverse effects such as sedation, apnoea, or addiction. Here, we use an unprecedented strategy and report the synthesis and analgesic efficacy of the standard opioid morphine covalently attached to hyperbranched polyglycerol (PG-M) by a cleavable linker. With its high-molecular weight and hydrophilicity, this conjugate is designed to selectively release morphine in injured tissue and to prevent blood-brain barrier permeation...
July 4, 2017: ELife
https://www.readbyqxmd.com/read/28667116/a-third-type-of-resistance-to-cydia-pomonella-granulovirus-in-codling-moths-shows-a-mixed-z-linked-and-autosomal-inheritance-pattern
#10
A J Sauer, S Schulze-Bopp, E Fritsch, K Undorf-Spahn, J A Jehle
Different isolates of Cydia pomonella granulovirus (CpGV) are used worldwide to control codling moth larvae (Cydia pomonella) in pome fruit production. Two types of dominantly inherited field resistance of C. pomonella to CpGV have been recently identified: Z-chromosomal type I resistance and autosomal type II resistance. In the present study, a CpGV-resistant C. pomonella field population (termed SA-GO) from northeastern Germany was investigated. SA-GO individuals showed cross-resistance to CpGV isolates of genome group A (CpGV-M) and genome group E (CpGV-S), whereas genome group B (CpGV-E2) was still infective...
September 1, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28660564/a-smartphone-application-to-determine-body-length-for-body-weight-estimation-in-children-a-prospective-clinical-trial
#11
Oliver Wetzel, Alexander R Schmidt, Michelle Seiler, Davide Scaramuzza, Burkhardt Seifert, Donat R Spahn, Philipp Stein
The aim of this study was to test the feasibility and accuracy of a smartphone application to measure the body length of children using the integrated camera and to evaluate the subsequent weight estimates. A prospective clinical trial of children aged 0-<13 years admitted to the emergency department of the University Children's Hospital Zurich. The primary outcome was to validate the length measurement by the smartphone application «Optisizer». The secondary outcome was to correlate the virtually calculated ordinal categories based on the length measured by the app to the categories based on the real length...
June 28, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28659436/broad-spectrum-antiviral-gs-5734-inhibits-both-epidemic-and-zoonotic-coronaviruses
#12
Timothy P Sheahan, Amy C Sims, Rachel L Graham, Vineet D Menachery, Lisa E Gralinski, James B Case, Sarah R Leist, Krzysztof Pyrc, Joy Y Feng, Iva Trantcheva, Roy Bannister, Yeojin Park, Darius Babusis, Michael O Clarke, Richard L Mackman, Jamie E Spahn, Christopher A Palmiotti, Dustin Siegel, Adrian S Ray, Tomas Cihlar, Robert Jordan, Mark R Denison, Ralph S Baric
Emerging viral infections are difficult to control because heterogeneous members periodically cycle in and out of humans and zoonotic hosts, complicating the development of specific antiviral therapies and vaccines. Coronaviruses (CoVs) have a proclivity to spread rapidly into new host species causing severe disease. Severe acute respiratory syndrome CoV (SARS-CoV) and Middle East respiratory syndrome CoV (MERS-CoV) successively emerged, causing severe epidemic respiratory disease in immunologically naïve human populations throughout the globe...
June 28, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28655625/impact-of-city-police-layperson-education-and-equipment-with-automatic-external-defibrillators-on-patient-outcome-after-out-of-hospital-cardiac-arrest
#13
Philipp Stein, Gabriela H Spahn, Stefan Müller, Andreas Zollinger, Werner Baulig, Martin Brüesch, Burkhardt Seifert, Donat R Spahn
INTRODUCTION: Out of hospital cardiac arrest (OHCA) occurs frequently and the outcome is often dismal. Early defibrillation saves lives and brain function in OHCA. The Zurich city police (STAPO) forces were instructed and equipped to provide basic life support (BLS) and to use an AED in 2009. METHODS: Retrospective observational study comparing period 1 (P1) 2004-2009 before equipping and training of the STAPO and period 2 (P2) 2010-2015 after the implementation...
September 2017: Resuscitation
https://www.readbyqxmd.com/read/28640892/novel-resistance-to-cydia-pomonella-granulovirus-cpgv-in-codling-moth-shows-autosomal-and-dominant-inheritance-and-confers-cross-resistance-to-different-cpgv-genome-groups
#14
Annette J Sauer, Eva Fritsch, Karin Undorf-Spahn, Petr Nguyen, Frantisek Marec, David G Heckel, Johannes A Jehle
Commercial Cydia pomonella granulovirus (CpGV) products have been successfully applied to control codling moth (CM) in organic and integrated fruit production for more than 30 years. Since 2005, resistance against the widely used isolate CpGV-M has been reported from different countries in Europe. The inheritance of this so-called type I resistance is dominant and linked to the Z chromosome. Recently, a second form (type II) of CpGV resistance in CM was reported from a field population (NRW-WE) in Germany. Type II resistance confers reduced susceptibility not only to CpGV-M but to most known CpGV isolates and it does not follow the previously described Z-linked inheritance of type I resistance...
2017: PloS One
https://www.readbyqxmd.com/read/28635402/analysing-the-vocal-behaviour-of-teachers-during-classroom-teaching-using-a-portable-voice-accumulator
#15
Manfred Nusseck, Bernhard Richter, Claudia Spahn, Matthias Echternach
PURPOSE: Teachers are at a considerable risk of developing vocal health problems due to intensive voice use during teaching. This study investigated factors related to the teacher's voice during a teaching situation. METHODS: Overall, 113 teachers were recorded during a typical class lesson, lasting on average 48 min. A portable voice dosimeter (VoxLog System) was used to measure the sound pressure level (SPL) of the noise in the classroom, the teacher's voice SPL, the fundamental frequency (fo) and the phonation time...
March 3, 2017: Logopedics, Phoniatrics, Vocology
https://www.readbyqxmd.com/read/28612425/iron-deficiency-across-chronic-inflammatory-conditions-international-expert-opinion-on-definition-diagnosis-and-management
#16
REVIEW
Maria Domenica Cappellini, Josep Comin-Colet, Angel de Francisco, Axel Dignass, Wolfram Doehner, Carolyn S P Lam, Iain C Macdougall, Gerhard Rogler, Clara Camaschella, Rezan Kadir, Nicholas J Kassebaum, Donat R Spahn, Ali T Taher, Khaled M Musallam
Iron deficiency, even in the absence of anemia, can be debilitating, and exacerbate any underlying chronic disease, leading to increased morbidity and mortality. Iron deficiency is frequently concomitant with chronic inflammatory disease; however, iron deficiency treatment is often overlooked, partially due to the heterogeneity among clinical practice guidelines. In the absence of consistent guidance across chronic heart failure, chronic kidney disease and inflammatory bowel disease, we provide practical recommendations for iron deficiency to treating physicians: definition, diagnosis, and disease-specific diagnostic algorithms...
October 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28608011/safety-of-anticoagulation-interruption-in-patients-undergoing-surgery-or-invasive-procedures-a-systematic-review-and-meta-analyses-of-randomized-controlled-trials-and-non-randomized-studies
#17
Frédérique Hovaguimian, Sabrina Köppel, Donat R Spahn
BACKGROUND: The safety of anticoagulation interruption in patients requiring surgical or invasive procedures remains unclear. We thus performed a systematic review and meta-analyses of randomized controlled trials (RCTs) and non-randomized studies (NRS). METHODS: MEDLINE, Embase and Central databases were searched to March 2017 without date or language restrictions. We considered RCTs and NRS comparing anticoagulation interruption with any anticoagulation (continuation or heparin bridging) in adult surgical patients taking oral anticoagulation...
June 12, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28603962/novel-opioid-analgesics-and-side-effects
#18
Giovanna Del Vecchio, Viola Spahn, Christoph Stein
Conventional opioids mediate analgesia as well as severe adverse effects via G-protein coupled opioid receptors (OR) in both inflamed (peripheral injured tissue) and healthy (brain, intestinal wall) environments. To exclude side effects, OR activation can be selectively achieved in damaged tissue by lowering the pKa of an opioid ligand to the acidic pH of inflammation. As a result, protonation of the ligand and consequent OR binding and activation of G-proteins is pH- and injury-specific. A novel compound (NFEPP) demonstrates the feasibility of this approach and displays blockade of pain transmission only at the peripheral site of injury, but with lack of central and gastrointestinal adverse effects...
August 16, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28596313/erratum-for-the-report-a-nontoxic-pain-killer-designed-by-modeling-of-pathological-receptor-conformations-by-v-spahn-g-del-vecchio-d-labuz-a-rodriguez-gaztelumendi-n-massaly-j-temp-v-durmaz-p-sabri-m-reidelbach-h-machelska-m-weber-c-stein
#19
https://www.readbyqxmd.com/read/28594141/patient-blood-management-the-new-standard
#20
EDITORIAL
Donat R Spahn
No abstract text is available yet for this article.
June 2017: Transfusion
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