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https://www.readbyqxmd.com/read/28635402/analysing-the-vocal-behaviour-of-teachers-during-classroom-teaching-using-a-portable-voice-accumulator
#1
Manfred Nusseck, Bernhard Richter, Claudia Spahn, Matthias Echternach
PURPOSE: Teachers are at a considerable risk of developing vocal health problems due to intensive voice use during teaching. This study investigated factors related to the teacher's voice during a teaching situation. METHODS: Overall, 113 teachers were recorded during a typical class lesson, lasting on average 48 min. A portable voice dosimeter (VoxLog System) was used to measure the sound pressure level (SPL) of the noise in the classroom, the teacher's voice SPL, the fundamental frequency (fo) and the phonation time...
March 3, 2017: Logopedics, Phoniatrics, Vocology
https://www.readbyqxmd.com/read/28612425/iron-deficiency-across-chronic-inflammatory-conditions-international-expert-opinion-on-definition-diagnosis-and-management
#2
REVIEW
Maria Domenica Cappellini, Josep Comin-Colet, Angel de Francisco, Axel Dignass, Wolfram Doehner, Carolyn Sp Lam, Iain C Macdougall, Gerhard Rogler, Clara Camaschella, Rezan Kadir, Nicholas J Kassebaum, Donat R Spahn, Ali T Taher, Khaled M Musallam
Iron deficiency, even in the absence of anemia, can be debilitating, and exacerbate any underlying chronic disease, leading to increased morbidity and mortality. Iron deficiency is frequently concomitant with chronic inflammatory disease; however, iron deficiency treatment is often overlooked, partially due to the heterogeneity among clinical practice guidelines. In the absence of consistent guidance across chronic heart failure, chronic kidney disease and inflammatory bowel disease, we provide practical recommendations for iron deficiency to treating physicians: definition, diagnosis, and disease-specific diagnostic algorithms...
June 13, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28608011/safety-of-anticoagulation-interruption-in-patients-undergoing-surgery-or-invasive-procedures-a-systematic-review-and-meta-analyses-of-randomized-controlled-trials-and-non-randomized-studies
#3
Frédérique Hovaguimian, Sabrina Köppel, Donat R Spahn
BACKGROUND: The safety of anticoagulation interruption in patients requiring surgical or invasive procedures remains unclear. We thus performed a systematic review and meta-analyses of randomized controlled trials (RCTs) and non-randomized studies (NRS). METHODS: MEDLINE, Embase and Central databases were searched to March 2017 without date or language restrictions. We considered RCTs and NRS comparing anticoagulation interruption with any anticoagulation (continuation or heparin bridging) in adult surgical patients taking oral anticoagulation...
June 12, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28603962/novel-opioid-analgesics-and-side-effects
#4
Giovanna Del Vecchio, Viola Spahn, Christoph Stein
Conventional opioids mediate analgesia as well as severe adverse effects via G-protein coupled opioid receptors (OR) in both inflamed (peripheral injured tissue) and healthy (brain, intestinal wall) environments. To exclude side effects, OR activation can be selectively achieved in damaged tissue by lowering the pKa of an opioid ligand to the acidic pH of inflammation. As a result, protonation of the ligand and consequent OR binding and activation of G-proteins is pH- and injury-specific. A novel compound (NFEPP) demonstrates the feasibility of this approach and displays blockade of pain transmission only at the peripheral site of injury, but with lack of central and gastrointestinal adverse effects...
June 12, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28596313/erratum-for-the-report-a-nontoxic-pain-killer-designed-by-modeling-of-pathological-receptor-conformations-by-v-spahn-g-del-vecchio-d-labuz-a-rodriguez-gaztelumendi-n-massaly-j-temp-v-durmaz-p-sabri-m-reidelbach-h-machelska-m-weber-c-stein
#5
https://www.readbyqxmd.com/read/28594141/patient-blood-management-the-new-standard
#6
EDITORIAL
Donat R Spahn
No abstract text is available yet for this article.
June 2017: Transfusion
https://www.readbyqxmd.com/read/28586062/therapy-relevant-aberrant-expression-of-mrp3-and-bcrp-mrna-in-tcc-scc-bladder-cancer-tissue-of-untreated-patients
#7
Mona Rady, Marwa Mostageer, Jan Rohde, Ashraf Zaghloul, Ruth Knüchel-Clarke, Shady Saad, Deena Attia, Laila Mahran, Hilde Spahn-Langguth
Multidrug resistance (MDR) is a critical factor, which results in suboptimal outcomes in cancer chemotherapy. One principal mechanism of MDR is the increased expression of ATP-binding cassette (ABC) transporters. Of these, multidrug resistance-associated protein 3 (MRP3) and breast cancer resistance protein (BCRP) confer MDR when overexpressed in cancer cell lines. We measured the mRNA expression of MRP3 and BCRP in primary untreated bladder cancer specimens using reverse transcription-quantitative PCR (RT-qPCR) in comparison to normal bladder tissue...
June 2, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28576440/photometric-assay-of-maltose-and-maltose-forming-enzyme-activity-by-using-4-alpha-glucanotransferase-dpe2-from-higher-plants
#8
Julia Smirnova, Alisdair R Fernie, Christian C M Spahn, Martin Steup
Maltose frequently occurs as intermediate of the central carbon metabolism of prokaryotic and eukaryotic cells. Various mutants possess elevated maltose levels. Maltose exists as two anomers, (α- and β-form) which are rapidly interconverted without requiring enzyme-mediated catalysis. As maltose is often abundant together with other oligoglucans, selective quantification is essential. In this communication, we present a photometric maltose assay using 4-alpha-glucanotransferase (AtDPE2) from Arabidopsis thaliana...
May 30, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28574582/production-of-g-protein-coupled-receptors-in-an-insect-based-cell-free-system
#9
Andrei Sonnabend, Viola Spahn, Marlitt Stech, Anne Zemella, Christoph Stein, Stefan Kubick
The biochemical analysis of human cell membrane proteins remains a challenging task due to the difficulties in producing sufficient quantities of functional protein. G protein-coupled receptors (GPCRs) represent a main class of membrane proteins and drug targets, which are responsible for a huge number of signaling processes regulating various physiological functions in living cells. To circumvent the current bottlenecks in GPCR studies, we propose the synthesis of GPCRs in eukaryotic cell-free systems based on extracts generated from insect (Sf21) cells...
June 2, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28570294/blind-intubation-through-self-pressurized-disposable-supraglottic-airway-laryngeal-intubation-masks-an-international-multicenter-prospective-cohort-study
#10
Kurt Ruetzler, Sandra Esther Guzzella, David Werner Tscholl, Tanja Restin, Marco Cribari, Alparslan Turan, Jing You, Daniel I Sessler, Burkhardt Seifert, Tomasz Gaszynski, Michael T Ganter, Donat R Spahn
INTRODUCTION: Supraglottic airway devices commonly are used for securing the airway during general anesthesia. Occasionally, intubation with an endotracheal tube through a supraglottic airway is indicated. Reported success rates for blind intubation range from 15 to 97%. The authors thus investigated as their primary outcome the fraction of patients who could be intubated blindly with an Air-Qsp supraglottic airway device (Mercury Medical, USA). Second, the authors investigated the influence of muscle relaxation on air leakage pressure, predictors for failed blind intubation, and associated complications of using the supraglottic airway device...
June 1, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28542848/change-of-transfusion-and-treatment-paradigm-in-major-trauma-patients
#11
P Stein, A Kaserer, K Sprengel, G A Wanner, B Seifert, O M Theusinger, D R Spahn
Trauma promotes trauma-induced coagulopathy, which requires urgent treatment with fixed-ratio transfusions of red blood cells, fresh frozen plasma and platelet concentrates, or goal-directed administration of coagulation factors based on viscoelastic testing. This retrospective observational study compared two time periods before (2005-2007) and after (2012-2014) the implementation of changes in trauma management protocols which included: use of goal-directed coagulation management; admission of patients to designated trauma centres; whole-body computed tomography scanning on admission; damage control surgery; permissive hypotension; restrictive fluid resuscitation; and administration of tranexamic acid...
May 23, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28521382/-coincidence-and-therapy-of-dysalignments-and-degenerative-knee-cartilage-lesions-results-from-the-german-cartilageregistry-dgou
#12
Gunter Spahn, Jürgen Fritz, Dirk Albrecht, Peter Angele, Stefan Fickert, Matthias Aurich, Gunther O Hofmann, Phillip Niemeyer
Purpose This multicenter study was aimed to evaluate the coincidence of degenerative knee cartilage lesions with a varus or valgus dysalignment. Furthermore, the frequency of the combined surgery of cartilage treatments and corrective osteotomies are determined. Material and Methods A total of 1778 patients were included in the German CartilageRegistry (deadline 01.08.2016). In 90.6% of patients, the surgeon calculated the alignment by clinical observation. Varus or valgus conditions were measured radiologically in only 56...
May 18, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28510510/a-nurse-practitioner-s-view-on-telehealth
#13
Kimberly Spahn
No abstract text is available yet for this article.
May 2017: Journal of the American Psychiatric Nurses Association
https://www.readbyqxmd.com/read/28510356/purification-of-recombinant-a%C3%AE-1-42-and-pglu-a%C3%AE-3-42-using-preparative-sds-page
#14
Claudia Spahn, Michael Wermann, Rico Eichentopf, Gerd Hause, Dagmar Schlenzig, Stephan Schilling
Recombinant expression and purification of amyloid peptides represents a common basis for investigating the molecular mechanisms of amyloid formation and toxicity. However, the isolation of the recombinant peptides is hampered by inefficient separation from contaminants such as the fusion protein required for efficient expression in E. coli. Here, we present a new approach for the isolation of highly purified Aβ(1-42) and pGlu-Aβ(3-42), which is based on a separation using preparative SDS-PAGE. The method relies on the purification of the Aβ fusion protein by affinity chromatography followed by preparative SDS-PAGE under reducing conditions and subsequent removal of detergents by precipitation...
May 16, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28489643/factors-influencing-quality-of-pain-management-in-a-physician-staffed-helicopter-emergency-medical-service
#15
Nicole Oberholzer, Alexander Kaserer, Roland Albrecht, Burkhardt Seifert, Mario Tissi, Donat R Spahn, Konrad Maurer, Philipp Stein
BACKGROUND: Pain is frequently encountered in the prehospital setting and needs to be treated quickly and sufficiently. However, incidences of insufficient analgesia after prehospital treatment by emergency medical services are reported to be as high as 43%. The purpose of this analysis was to identify modifiable factors in a specific emergency patient cohort that influence the pain suffered by patients when admitted to the hospital. METHODS: For that purpose, this retrospective observational study included all patients with significant pain treated by a Swiss physician-staffed helicopter emergency service between April and October 2011 with the following characteristics to limit selection bias: Age > 15 years, numerical rating scale (NRS) for pain documented at the scene and at hospital admission, NRS > 3 at the scene, initial Glasgow coma scale > 12, and National Advisory Committee for Aeronautics score < VI...
July 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28485390/the-survival-impact-of-neoadjuvant-hormonal-therapy-before-radical-prostatectomy-for-treatment-of-high-risk-prostate-cancer
#16
L Tosco, A Laenen, A Briganti, P Gontero, R J Karnes, M Albersen, P J Bastian, P Chlosta, F Claessens, F K Chun, W Everaerts, C Gratzke, M Graefen, B Kneitz, G Marchioro, R S Salas, B Tombal, T Van den Broeck, L Moris, A Battaglia, H van der Poel, J Walz, A Bossi, G De Meerleer, K Haustermans, H Van Poppel, M Spahn, S Joniau
BACKGROUND: Several randomized controlled trials assessed the outcomes of patients treated with neoadjuvant hormonal therapy (NHT) before radical prostatectomy (RP). The majority of them included mainly low and intermediate risk prostate cancer (PCa) without specifically assessing PCa-related death (PCRD). Thus, there is a lack of knowledge regarding a possible effect of NHT on PCRD in the high-risk PCa population. We aimed to analyze the effect of NHT on PCRD in a multicenter high-risk PCa population treated with RP, using a propensity-score adjustment...
May 9, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28481380/factors-for-and-against-establishing-and-working-in-private-practice-correlated-with-work-related-behavior-and-experience-patterns-of-ferman-physicians-in-schleswig-holstein-a-2-year-longitudinal-study
#17
Edgar Voltmer, Claudia Spahn, Erica Frank
OBJECTIVES: To identify factors in favor of or against establishing and working in private practice, to determine the quality of life and work-related behavior and experience patterns of German physicians working in private practice, and to analyze the correlation of those factors. MATERIAL AND METHODS: A representative sample of physicians in private practice in Schleswig-Holstein, Germany, was surveyed according to a 2-year longitudinal design (T1 - 2008, N = 549 and T2 - 2010, N = 414)...
May 8, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28469086/iron-accelerates-hemoglobin-oxidation-increasing-mortality-in-vascular-diseased-guinea-pigs-following-transfusion-of-stored-blood
#18
Jin Hyen Baek, Ayla Yalamanoglu, Yamei Gao, Ricardo Guenster, Donat R Spahn, Dominik J Schaer, Paul W Buehler
Non-transferrin-bound iron (NTBI) and free hemoglobin (Hb) accumulate in circulation following stored RBC transfusions. This study investigated transfusion, vascular disease, and mortality in guinea pigs after stored RBC transfusion alone and following cotransfusion with apo-transferrin (apo-Tf) and haptoglobin (Hp). The effects of RBC exchange transfusion dose (1, 3, and 9 units), storage period (14 days), and mortality were evaluated in guinea pigs with a vascular disease phenotype. Seven-day mortality and the interaction between iron and Hb as cocontributors to adverse outcome were studied...
May 4, 2017: JCI Insight
https://www.readbyqxmd.com/read/28452979/structural-basis-for-%C3%AE-n-dependent-processive-transcription-antitermination
#19
Nelly Said, Ferdinand Krupp, Ekaterina Anedchenko, Karine F Santos, Olexandr Dybkov, Yong-Heng Huang, Chung-Tien Lee, Bernhard Loll, Elmar Behrmann, Jörg Bürger, Thorsten Mielke, Justus Loerke, Henning Urlaub, Christian M T Spahn, Gert Weber, Markus C Wahl
λN-mediated processive antitermination constitutes a paradigmatic transcription regulatory event, during which phage protein λN, host factors NusA, NusB, NusE and NusG, and an RNA nut site render elongating RNA polymerase termination-resistant. The structural basis of the process has so far remained elusive. Here we describe a crystal structure of a λN-NusA-NusB-NusE-nut site complex and an electron cryo-microscopic structure of a complete transcription antitermination complex, comprising RNA polymerase, DNA, nut site RNA, all Nus factors and λN, validated by crosslinking/mass spectrometry...
April 28, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28429311/improving-animal-welfare-using-continuous-nalbuphine-infusion-in-a-long-term-rat-model-of-sepsis
#20
Victor Jeger, Mattia Arrigo, Florian F Hildenbrand, Daniel Müller, Paulin Jirkof, Till Hauffe, Burkhardt Seifert, Margarete Arras, Donat R Spahn, Dominique Bettex, Alain Rudiger
BACKGROUND: Sepsis research relies on animal models to investigate the mechanisms of the dysregulated host response to infection. Animal welfare concerns request the use of potent analgesics for the Refinement of existing sepsis models, according to the 3Rs principle. Nevertheless, adequate analgesia is often missing, partly because the effects of analgesics in this particular condition are unknown. We evaluated the use of nalbuphine, an opioid with kappa agonistic and mu antagonistic effects, in rats with and without experimental sepsis...
December 2017: Intensive Care Medicine Experimental
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