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https://www.readbyqxmd.com/read/28429311/improving-animal-welfare-using-continuous-nalbuphine-infusion-in-a-long-term-rat-model-of-sepsis
#1
Victor Jeger, Mattia Arrigo, Florian F Hildenbrand, Daniel Müller, Paulin Jirkof, Till Hauffe, Burkhardt Seifert, Margarete Arras, Donat R Spahn, Dominique Bettex, Alain Rudiger
BACKGROUND: Sepsis research relies on animal models to investigate the mechanisms of the dysregulated host response to infection. Animal welfare concerns request the use of potent analgesics for the Refinement of existing sepsis models, according to the 3Rs principle. Nevertheless, adequate analgesia is often missing, partly because the effects of analgesics in this particular condition are unknown. We evaluated the use of nalbuphine, an opioid with kappa agonistic and mu antagonistic effects, in rats with and without experimental sepsis...
December 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/28397004/the-frequency-of-cartilage-lesions-in-non-injured-knees-with-symptomatic-meniscus-tears-results-from-an-arthroscopic-and-nir-near-infrared-spectroscopic-investigation
#2
Gunter Spahn, Holger Plettenberg, Martin Hoffmann, Holm-Torsten Klemm, Christoph Brochhausen-Delius, Gunther O Hofmann
INTRODUCTION: Are symptomatic tear injuries to the menisci of the knee frequently or always associated with cartilage damage to the corresponding articular surfaces and other joint surfaces, respectively? METHODS: A total of 137 patients (medial n = 127; lateral n = 10) underwent a meniscus resection. These patients showed no signs of a clear radiographic arthrosis and no MRI-detectable cartilage lesions > grade II. Traumatic injury was ruled out with a thorough medical history...
April 10, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28368907/prevalence-and-in-hospital-outcome-of-aspiration-in-out-of-hospital-intubated-trauma-patients
#3
Raluca R Radu, Alexander Kaserer, Burkhardt Seifert, Hans-Peter Simmen, Kurt Ruetzler, Donat R Spahn, Valentin Neuhaus
No abstract text is available yet for this article.
March 31, 2017: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://www.readbyqxmd.com/read/28331607/-simplified-international-recommendations-for-the-implementation-of-patient-blood-management-sir4pbm
#4
Patrick Meybohm, Bernd Froessler, Lawrence T Goodnough, Andrew A Klein, Manuel Muñoz, Michael F Murphy, Toby Richards, Aryeh Shander, Donat R Spahn, Kai Zacharowski
BACKGROUND: More than 30% of the world's population are anemic with serious medical and economic consequences. Red blood cell transfusion is the mainstay to correct anemia, but it is also one of the top five overused procedures and carries its own risk and cost burden. Patient blood management (PBM) is a patient-centered and multidisciplinary approach to manage anemia, minimize iatrogenic blood loss, and harness tolerance to anemia in an effort to improve patient outcome. Despite resolution 63...
2017: Perioperative Medicine
https://www.readbyqxmd.com/read/28328758/posttransfusion-increase-of-hematocrit-per-se-does-not-improve-circulatory-oxygen-delivery-due-to-increased-blood-viscosity
#5
Robert Zimmerman, Amy G Tsai, Beatriz Y Salazar Vázquez, Pedro Cabrales, Axel Hofmann, Jens Meier, Aryeh Shander, Donat R Spahn, Joel M Friedman, Daniel M Tartakovsky, Marcos Intaglietta
BACKGROUND: Blood transfusion is used to treat acute anemia with the goal of increasing blood oxygen-carrying capacity as determined by hematocrit (Hct) and oxygen delivery (DO2). However, increasing Hct also increases blood viscosity, which may thus lower DO2 if the arterial circulation is a rigid hydraulic system as the resistance to blood flow will increase. The net effect of transfusion on DO2 in this system can be analyzed by using the relationship between Hct and systemic blood viscosity of circulating blood at the posttransfusion Hct to calculate DO2 and comparing this value with pretransfusion DO2...
May 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28297730/point-of-care-coagulation-monitoring-in-trauma-patients
#6
Philipp Stein, Alexander Kaserer, Gabriela H Spahn, Donat R Spahn
Trauma remains one of the major causes of death and disability all over the world. Uncontrolled blood loss and trauma-induced coagulopathy represent preventable causes of trauma-related morbidity and mortality. Treatment may consist of allogeneic blood product transfusion at a fixed ratio or in an individualized goal-directed way based on point-of-care (POC) and routine laboratory measurements. Viscoelastic POC measurement of the developing clot in whole blood and POC platelet function testing allow rapid and tailored coagulation and transfusion treatment based on goal-directed, factor concentrate-based algorithms...
March 15, 2017: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/28254944/a-nontoxic-pain-killer-designed-by-modeling-of-pathological-receptor-conformations
#7
V Spahn, G Del Vecchio, D Labuz, A Rodriguez-Gaztelumendi, N Massaly, J Temp, V Durmaz, P Sabri, M Reidelbach, H Machelska, M Weber, C Stein
Indiscriminate activation of opioid receptors provides pain relief but also severe central and intestinal side effects. We hypothesized that exploiting pathological (rather than physiological) conformation dynamics of opioid receptor-ligand interactions might yield ligands without adverse actions. By computer simulations at low pH, a hallmark of injured tissue, we designed an agonist that, because of its low acid dissociation constant, selectively activates peripheral μ-opioid receptors at the source of pain generation...
March 3, 2017: Science
https://www.readbyqxmd.com/read/28236186/risk-factors-for-cartilage-damage-and-osteoarthritis-of-the-elbow-joint-case-control-study-and-systematic-literature-review
#8
Gunter Spahn, Jens Uwe Lipfert, Constance Maurer, Bernd Hartmann, Rainer Schiele, Holm-Torsten Klemm, Joachim Grifka, Gunther O Hofmann
INTRODUCTION: This case-control study compares patients with healthy elbows to a group of symptomatic patients with cartilage damage/osteoarthritis. MATERIALS AND METHODS: The control group (n = 126) was recruited during routine medical examinations of patients (general medical offices). Included in the case group were a total of 92 patients who were undergoing arthroscopy as a result of chronic elbow discomfort. All patients were questioned with regard to occupational stress and athletic stress...
February 24, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28220605/outcome-predictors-of-radical-cystectomy-in-patients-with-ct4-prostate-cancer-a-multi-institutional-study-of-62-patients
#9
Martin Spahn, Alessandro Morlacco, Silvan Boxler, Steven Joniau, Alberto Briganti, Francesco Montorsi, Paolo Gontero, Pia Bader, Detlef Frohneberg, Hein van Poppel, R Jeffrey Karnes
OBJECTIVES: To identify which patients with macroscopic bladder infiltrating T4 prostate cancer (PCa) might have favorable outcomes when treated with radical cystectomy (RC) MATERIALS AND METHODS: We evaluated 62 patients with cT4cN0-1cM0 PCa treated with RC and pelvic lymph node dissection between 1972-2011. In addition to descriptive statistics, the Kaplan-Meier method and log-rank tests were used to depict survival rates. Uni- and multivariate Cox regression analysis tested the association between predictors and progression-free, PCa-specific-, and overall survival...
February 20, 2017: BJU International
https://www.readbyqxmd.com/read/28198742/a-reliability-study-using-a-long-wave-infrared-thermography-device-to-identify-relative-tissue-temperature-variations-of-the-body-surface-and-underlying-tissue
#10
Diane K Langemo, James G Spahn
OBJECTIVE: This study assesses the ability of the Scout (WoundVision LLC, Indianapolis, Indiana), an FDA-approved visual and thermal imaging device and software analysis tool, to provide clinicians with a reliable and reproducible way to incorporate long-wave infrared thermography and relative temperature differential into clinical wound assessment by consistently identifying control areas against which to measure wound temperature. METHODS: This laboratory-based study utilized 3 adult wound care professionals experienced in control area selection...
March 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28182310/ankyrin-rich-membrane-spanning-protein-as-a-novel-modulator-of-transient-receptor-potential-vanilloid-1-function-in-nociceptive-neurons
#11
J Peter, C Kasper, M Kaufholz, R Buschow, J Isensee, T Hucho, F W Herberg, F Schwede, C Stein, S-E Jordt, M Brackmann, V Spahn
BACKGROUND: The ion channel TRPV1 is mainly expressed in small diameter dorsal root ganglion (DRG) neurons, which are involved in the sensation of acute noxious thermal and chemical stimuli. Direct modifications of the channel by diverse signalling events have been intensively investigated, but little is known about the composition of modulating macromolecular TRPV1 signalling complexes. Here, we hypothesize that the novel adaptor protein ankyrin-rich membrane spanning protein/kinase D interacting substrate (ARMS) interacts with TRPV1 and modulates its function in rodent DRG neurons...
February 9, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28173160/pathogenic-inflammation-in-the-cns-of-mice-carrying-human-plp1-mutations
#12
Janos Groh, Hana C Friedman, Nadiya Orel, Chi Wang Ip, Stefan Fischer, Irene Spahn, Erik Schäffner, Michaela Hörner, David Stadler, Mathias Buttmann, Csanad Varallyay, László Solymosi, Michael Sendtner, Alan C Peterson, Rudolf Martini
No abstract text is available yet for this article.
November 1, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/28164422/effect-of-prophylactic-topical-hypotensive-medications-in-reducing-the-incidence-of-postoperative-ocular-hypertension-after-phacoemulsification-in-dogs
#13
D Dustin Dees, Kate J Spahn, Lynsey Smith Wagner, Andrew Greller, Danielle Paglia, Micki D Armour, Richard Madsen
OBJECTIVE: To determine whether topical hypotensive medications prevent postoperative ocular hypertension (POH) after phacoemulsification. ANIMALS STUDIED: 52 client-owned dogs (88 eyes). PROCEDURES: Diabetic and nondiabetic dogs having undergone phacoemulsification were included in this retrospective study. The control group received no ocular hypotensive medications. The treatment groups received latanoprost, dorzolamide, or dorzolamide/timolol, beginning immediately after surgery, for 2-week duration...
February 6, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28067701/economic-evaluation-of-pharmacologic-pre-and-postconditioning-with-sevoflurane-compared-with-total-intravenous-anesthesia-in-liver-surgery-a-cost-analysis
#14
Klaus Eichler, Martin Urner, Claudia Twerenbold, Sabine Kern, Urs Brügger, Donat R Spahn, Beatrice Beck-Schimmer, Michael T Ganter
BACKGROUND: Pharmacologic pre- and postconditioning with sevoflurane compared with total IV anesthesia in patients undergoing liver surgery reduced complication rates as shown in 2 recent randomized controlled trials. However, the potential health economic consequences of these different anesthesia regimens have not yet been assessed. METHODS: An expostcost analysis of these 2 trials in 129 patients treated between 2006 and 2010 was performed. We analyzed direct medical costs for in-hospital stay and compared pharmacologic pre- and postconditioning with sevoflurane (intervention) with total IV anesthesia (control) from the perspective of a Swiss university hospital...
March 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28018903/impact-of-lymph-node-burden-on-survival-of-high-risk-prostate-cancer-patients-following-radical-prostatectomy-and-pelvic-lymph-node-dissection
#15
Lisa Moris, Thomas Van den Broeck, Lorenzo Tosco, Anthony Van Baelen, Paolo Gontero, Robert Jeffrey Karnes, Wouter Everaerts, Maarten Albersen, Patrick J Bastian, Piotr Chlosta, Frank Claessens, Felix K Chun, Markus Graefen, Christian Gratzke, Burkhard Kneitz, Giansilvio Marchioro, Rafael Sanchez Salas, Bertrand Tombal, Henk Van Der Poel, Jochen Christoph Walz, Gert De Meerleer, Alberto Bossi, Karin Haustermans, Francesco Montorsi, Hendrik Van Poppel, Martin Spahn, Alberto Briganti, Steven Joniau
AIM: To determine the impact of the extent of lymph node invasion (LNI) on long-term oncological outcomes after radical prostatectomy (RP). MATERIAL AND METHODS: In this retrospective study, we examined the data of 1,249 high-risk, non-metastatic PCa patients treated with RP and pelvic lymph node dissection (PLND) between 1989 and 2011 at eight different tertiary institutions. We fitted univariate and multivariate Cox models to assess independent predictors of cancer-specific survival (CSS) and overall survival (OS)...
2016: Frontiers in Surgery
https://www.readbyqxmd.com/read/28001096/targeting-delta-opioid-receptors-for-pain-treatment-drugs-in-phase-i-and-ii-clinical-development
#16
REVIEW
Viola Spahn, Christoph Stein
Opioids are widely used to treat severe pain. Most clinically used opioids activate µ-opioid receptors (MOR). Their ligands induce potent analgesia but also adverse effects. The δ-opioid receptor (DOR) is another member of the opioid receptor family that has been under intense investigation with the aim to avoid MOR-induced side effects. Areas covered: This article reviews DOR ligands which appeared to be promising after preclinical evaluation. A literature search using Pubmed, Cochrane library, ClinicalTrials...
February 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/27996086/international-consensus-statement-on-the-peri-operative-management-of-anaemia-and-iron-deficiency
#17
M Muñoz, A G Acheson, M Auerbach, M Besser, O Habler, H Kehlet, G M Liumbruno, S Lasocki, P Meybohm, R Rao Baikady, T Richards, A Shander, C So-Osman, D R Spahn, A A Klein
Despite current recommendations on the management of pre-operative anaemia, there is no pragmatic guidance for the diagnosis and management of anaemia and iron deficiency in surgical patients. A number of experienced researchers and clinicians took part in an expert workshop and developed the following consensus statement. After presentation of our own research data and local policies and procedures, appropriate relevant literature was reviewed and discussed. We developed a series of best-practice and evidence-based statements to advise on patient care with respect to anaemia and iron deficiency in the peri-operative period...
December 20, 2016: Anaesthesia
https://www.readbyqxmd.com/read/27995908/structural-insights-into-ribosomal-rescue-by-dom34-and-hbs1-at-near-atomic-resolution
#18
Tarek Hilal, Hiroshi Yamamoto, Justus Loerke, Jörg Bürger, Thorsten Mielke, Christian M T Spahn
The surveillance of mRNA translation is imperative for homeostasis. Monitoring the integrity of the message is essential, as the translation of aberrant mRNAs leads to stalling of the translational machinery. During ribosomal rescue, arrested ribosomes are specifically recognized by the conserved eukaryotic proteins Dom34 and Hbs1, to initiate their recycling. Here we solve the structure of Dom34 and Hbs1 bound to a yeast ribosome programmed with a nonstop mRNA at 3.3 Å resolution using cryo-electron microscopy...
December 20, 2016: Nature Communications
https://www.readbyqxmd.com/read/27958271/nanoscopy-of-bacterial-cells-immobilized-by-holographic-optical-tweezers
#19
Robin Diekmann, Deanna L Wolfson, Christoph Spahn, Mike Heilemann, Mark Schüttpelz, Thomas Huser
Imaging non-adherent cells by super-resolution far-field fluorescence microscopy is currently not possible because of their rapid movement while in suspension. Holographic optical tweezers (HOTs) enable the ability to freely control the number and position of optical traps, thus facilitating the unrestricted manipulation of cells in a volume around the focal plane. Here we show that immobilizing non-adherent cells by optical tweezers is sufficient to achieve optical resolution well below the diffraction limit using localization microscopy...
December 13, 2016: Nature Communications
https://www.readbyqxmd.com/read/27957836/regioselective-iron-catalyzed-2-2-2-cycloaddition-reaction-forming-4-6-disubstituted-2-aminopyridines-from-terminal-alkynes-and-cyanamides
#20
Nathan A Spahn, Minh H Nguyen, Jonas Renner, Timothy K Lane, Janis Louie
Iron complexes bound by redox-active pyridine dialdimine (PDAI) ligands catalyze the cycloaddition of two terminal alkynes and one cyanamide. The reaction is both chemo- and regioselective, as only 4,6-disubstituted 2-aminopyridine products are formed in moderate to high yields. Isolation of an iron azametallacycle (4) suggests that catalyst deactivation occurs with a large excess of cyanamide over longer reaction times. Fe-catalyzed cycloaddition allowed for a straightforward synthesis of a variety of aminopyridines, including known estrogen receptor ligands...
January 6, 2017: Journal of Organic Chemistry
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