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https://www.readbyqxmd.com/read/29331091/terminal-spreading-depolarization-and-electric-silence-in-death-of-human-cortex
#1
Jens P Dreier, Sebastian Major, Brandon Foreman, Maren K L Winkler, Eun-Jeung Kang, Denny Milakara, Coline L Lemale, Vince DiNapoli, Jason M Hinzman, Johannes Woitzik, Norberto Andaluz, Andrew Carlson, Jed A Hartings
OBJECTIVE: Restoring the circulation is the primary goal in emergency treatment of cerebral ischemia. However, better understanding of how the brain responds to energy depletion could inform the time available for resuscitation until irreversible damage and advance development of interventions that prolong this span. Experimentally, injury to central neurons begins only with anoxic depolarization. This potentially reversible, spreading wave typically starts 2-5 min after the onset of severe ischemia, marking the onset of a toxic intraneuronal change that eventually results in irreversible injury...
January 13, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29330595/consistency-not-speed-temporal-regularity-as-a-metacognitive-cue
#2
Lisa M Stevenson, Richard A Carlson
We examined the hypothesis that skilled performance is monitored on the basis of fluency, where fluency is operationally defined as temporal regularity or rhythmicity rather than speed. Since error is often associated with variable timing, we tested the possibility that people use varied timing as a metacognitive cue. Using a sequential counting task, which may be representative of the broader class of skilled, multi-step tasks, we found that shifting between irregular and regular timing led to greater confidence ratings when the timing associated with the task was regular...
January 12, 2018: Psychological Research
https://www.readbyqxmd.com/read/29323364/graphene-template-induced-growth-of-single-crystalline-gold-nanobelts-with-high-structural-tunability
#3
Wenbo Xin, Igor M De Rosa, Peiyi Ye, Joseph Severino, Chao Li, Xunqian Yin, Mark S Goorsky, Larry Carlson, Jenn-Ming Yang
Assembling Au nanocrystals with tunable dimensions and shapes on graphene templates has attracted increasing attention recently. However, directly growing anisotropic Au nanobelts on a graphene support has been rarely reported. Here, a facile, one-pot, and surfactant-free route is demonstrated to synthesize well-defined Au nanobelts with the induction of a multilayer graphene (mlG) template. The obtained Au nanobelts are single-crystalline with a preferable (111) orientation. More importantly, their structural evolution starting from Au clusters is systematically investigated using scanning electron microscopy (SEM) and transmission electron microscopy (TEM)...
January 11, 2018: Nanoscale
https://www.readbyqxmd.com/read/29322591/inter-rater-agreement-of-novel-high-resolution-impedance-manometry-metrics-bolus-flow-time-and-esophageal-impedance-integral-ratio
#4
D A Carlson, Z Lin, W Kou, J E Pandolfino
BACKGROUND: Novel high-resolution impedance manometry (HRIM) metrics of bolus flow time (BFT) and esophageal impedance integral (EII) ratio have demonstrated clinical utility, though the reliability of their analysis has not been assessed. We aimed to evaluate the inter-rater agreement of the BFT and EII ratio. METHODS: HRIM studies including five upright, liquid swallows from 40 adult patients were analyzed by two raters using a customized MATLAB program to generate the BFT and EII ratio...
January 11, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29320378/an-examination-of-fluoxetine-for-the-treatment-of-selective-mutism-using-a-nonconcurrent-multiple-baseline-single-case-design-across-5-cases
#5
Justin A Barterian, Joel M Sanchez, Jed Magen, Allison K Siroky, Brittany L Mash, John S Carlson
This study examined the utility of fluoxetine in the treatment of 5 children, aged 5 to 14 years, diagnosed with selective mutism who also demonstrated symptoms of social anxiety. A nonconcurrent, randomized, multiple-baseline, single-case design with a single-blind placebo-controlled procedure was used. Parents and the study psychiatrist completed multiple methods of assessment including Direct Behavior Ratings and questionnaires. Treatment outcomes were evaluated by calculating effect sizes for each participant as an individual and for the participants as a group...
January 2018: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/29320320/mr-imaging-and-cochlear-implants-with-retained-internal-magnets-reducing-artifacts-near-highly-inhomogeneous-magnetic-fields
#6
Heidi A Edmonson, Matthew L Carlson, Alice C Patton, Robert E Watson
The number of patients receiving cochlear implants and auditory brainstem implants for severe to profound sensorineural hearing loss has rapidly increased. These implants consist of an internal component implanted between the skull and the temporal scalp and an external removable speech processor unit. A small magnet within the internal component is commonly used to hold the external speech processor unit in place. Several cochlear implant models have recently received U.S. Food and Drug Administration and European Economic Area regulatory approval to allow magnetic resonance (MR) imaging examinations to be performed under certain specified conditions...
January 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29318574/prophylactic-benefits-of-systemically-delivered-simvastatin-treatment-in-a-house-dust-mite-challenged-murine-model-of-allergic-asthma
#7
Aruni Jha, Min H Ryu, O O Ojo, Hilary J Bews, Jules C Carlson, Jacquie Schwartz, Sujata Basu, Charles S Wong, Andrew J Halayko
BACKGROUND AND PURPOSE: Systemically delivered statins can blunt airway inflammation in ovalbumin-challenged mice; however, in asthma clinical trials the beneficial effects of introducing oral statins are not compelling. We aim to reconcile this discrepancy using a clinically relevant murine model of allergic asthma, and by including a prophylactic study arm. EXPERIMENTAL APPROACH: Adult mice were: 1) challenged with house dust mite (HDM) alone or with subcutaneous (s...
January 10, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29315993/evaluating-the-reliability-and-construct-validity-of-the-eckardt-symptom-score-as-a-measure-of-achalasia-severity
#8
T H Taft, D A Carlson, J Triggs, J Craft, K Starkey, R Yadlapati, D Gregory, J E Pandolfino
BACKGROUND: Achalasia is a disease of mechanical esophageal dysfunction characterized by dysphagia, chest pain, regurgitation, and malnutrition. The Eckardt symptom score (ESS) is the gold standard self-report assessment tool. Current guidelines outline a three-step approach to patient reported outcomes measure design. Developed prior to these policies, the ESS has not undergone rigorous testing of its reliability and validity. METHODS: Adult achalasia patients retrospectively identified via a patient registry were grouped based on treatment history...
January 8, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29313216/chemical-speciation-and-fate-of-tripolyphosphate-after-application-to-a-calcareous-soil
#9
Jordan G Hamilton, Jay Grosskleg, David Hilger, Kris Bradshaw, Trevor Carlson, Steven D Siciliano, Derek Peak
Adsorption and precipitation reactions often dictate the availability of phosphorus in soil environments. Tripolyphosphate (TPP) is considered a form of slow release P fertilizer in P limited soils, however, investigations of the chemical fate of TPP in soils are limited. It has been proposed that TPP rapidly hydrolyzes in the soil solution before adsorbing or precipitating with soil surfaces, but in model systems, TPP also adsorbs rapidly onto mineral surfaces. To study the adsorption behavior of TPP in calcareous soils, a short-term (48 h) TPP spike was performed under laboratory conditions...
January 8, 2018: Geochemical Transactions
https://www.readbyqxmd.com/read/29306816/-you-got-to-love-rosin-solventless-dabs-pure-clean-natural-medicine-exploring-twitter-data-on-emerging-trends-in-rosin-tech-marijuana-concentrates
#10
Francois R Lamy, Raminta Daniulaityte, Mussah Zatreh, Ramzi W Nahhas, Amit Sheth, Silvia S Martins, Edward W Boyer, Robert G Carlson
BACKGROUND: "Rosin tech" is an emerging solventless method consisting in applying moderate heat and constant pressure on marijuana flowers to prepare marijuana concentrates referred to as "rosin." This paper explores rosin concentrate-related Twitter data to describe tweet content and analyze differences in rosin-related tweeting across states with varying cannabis legal statuses. METHOD: English language tweets were collected between March 15, 2015 and April 17, 2017, using Twitter API...
December 27, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29306730/role-of-metabolic-syndrome-on-perioperative-and-oncological-outcomes-at-radical-prostatectomy-in-a-low-risk-prostate-cancer-cohort-potentially-eligible-for-active-surveillance
#11
Michele Colicchia, Alessandro Morlacco, Laureano J Rangel, Rachel E Carlson, Fabrizio Dal Moro, R Jeffrey Karnes
BACKGROUND: Metabolic syndrome (MetS) is considered a potential risk factor for adverse outcomes after radical prostatectomy (RP). Furthermore, studies about the effect of MetS on low-risk prostate cancer (PCa) and its implications in active surveillance (AS) are limited. OBJECTIVE: To investigate the role of MetS (using International Diabetes Federation-American Heart Association/National Heart, Lung, and Blood Institute criteria) on perioperative and oncological outcomes after RP in low-risk PCa and in a subgroup potentially eligible for AS...
January 3, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29305694/pervasiveness-of-uvc254-resistant-geobacillus-strains-in-extreme-environments
#12
Courtney Carlson, Nitin K Singh, Mohit Bibra, Rajesh K Sani, Kasthuri Venkateswaran
We have characterized a broad collection of extremophilic bacterial isolates from a deep subsurface mine, compost dumping sites, and several hot spring ecosystems. Spore-forming strains isolated from these environments comprised both obligate thermophiles/thermotolerant species (growing at > 55 °C; 240 strains) and mesophiles (growing at 15 to 40 °C; 12 strains). An overwhelming abundance of Geobacillus (81.3%) and Bacillus (18.3%) species was observed among the tested isolates. 16S rRNA sequence analysis documented the presence of 24 species among these isolates, but the 16S rRNA gene was shown to possess insufficient resolution to reliably discern Geobacillus phylogeny...
January 5, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29304217/elevated-markers-of-inflammation-are-associated-with-longitudinal-changes-in-brain-function-in-older-adults
#13
Kristen N Warren, Lori L Beason-Held, Olga Carlson, Josephine M Egan, Yang An, Jimit Doshi, Christos Davatzikos, Luigi Ferrucci, Susan M Resnick
Background: Chronic inflammation has been linked to memory and other cognitive impairments, as well as Alzheimer's disease. Here, we investigate the association between inflammatory markers and changes in brain activity measured by regional cerebral blood flow (rCBF) to assess the relationship between inflammation and brain function in older individuals. Methods: Annual 15O water resting-state positron emission tomography (PET) scans collected over a 5-year period were assessed in 138 cognitively normal older participants (77 males; mean age at baseline = 71...
January 3, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29303450/subcutaneous-bone-flap-storage-after-emergency-craniectomy-cost-effectiveness-and-rate-of-resorption
#14
Griffin Ernst, Fares Qeadan, Andrew P Carlson
OBJECTIVE Decompressive craniectomy is used for uncontrolled intracranial pressure in traumatic brain injury and malignant hemispheric stroke. Subcutaneous preservation of the autologous bone flap in the abdomen is a simple, portable technique but has largely been abandoned due to perceived concerns of resorption. The authors sought to characterize their experience with subcutaneous preservation of the bone flap and cranioplasty. METHODS The authors performed a retrospective single-institution review of subcutaneous preservation of the autologous bone flap after decompressive craniectomy from 2005 to 2015...
January 5, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29302013/elevated-hla-a-expression-impairs-hiv-control-through-inhibition-of-nkg2a-expressing-cells
#15
Veron Ramsuran, Vivek Naranbhai, Amir Horowitz, Ying Qi, Maureen P Martin, Yuko Yuki, Xiaojiang Gao, Victoria Walker-Sperling, Gregory Q Del Prete, Douglas K Schneider, Jeffrey D Lifson, Jacques Fellay, Steven G Deeks, Jeffrey N Martin, James J Goedert, Steven M Wolinsky, Nelson L Michael, Gregory D Kirk, Susan Buchbinder, David Haas, Thumbi Ndung'u, Philip Goulder, Peter Parham, Bruce D Walker, Jonathan M Carlson, Mary Carrington
The highly polymorphic human leukocyte antigen (HLA) locus encodes cell surface proteins that are critical for immunity. HLA-A expression levels vary in an allele-dependent manner, diversifying allele-specific effects beyond peptide-binding preference. Analysis of 9763 HIV-infected individuals from 21 cohorts shows that higher HLA-A levels confer poorer control of HIV. Elevated HLA-A expression provides enhanced levels of an HLA-A-derived signal peptide that specifically binds and determines expression levels of HLA-E, the ligand for the inhibitory NKG2A natural killer (NK) cell receptor...
January 5, 2018: Science
https://www.readbyqxmd.com/read/29300677/nuclear-populations-of-the-multinucleate-fungus-of-leafcutter-ants-can-be-dekaryotized-and-recombined-to-manipulate-growth-of-nutritive-hyphal-nodules-harvested-by-the-ants
#16
Alexis L Carlson, Heather D Ishak, James Kurian, Alexander S Mikheyev, Isaac Gifford, Ulrich G Mueller
We dekaryotized the multinucleate fungus Leucocoprinus gongylophorus, a symbiotic fungus cultivated vegetatively by leafcutter ants as their food. To track genetic changes resulting from dekaryotization (elimination of some nuclei from the multinuclear population), we developed two multiplex microsatellite fingerprinting panels (15 loci total), then characterized the allele profiles of 129 accessions generated by dekaryotization treatment. Genotype profiles of the 129 accessions confirmed allele loss expected by dekaryotization of the multinucleate fungus...
November 10, 2017: Mycologia
https://www.readbyqxmd.com/read/29296973/high-throughput-sequencing-of-the-b-cell-receptor-in-african-burkitt-lymphoma-reveals-clues-to-pathogenesis
#17
Katharine A Lombardo, David G Coffey, Alicia J Morales, Christopher S Carlson, Andrea M H Towlerton, Sarah E Gerdts, Francis K Nkrumah, Janet Neequaye, Robert J Biggar, Jackson Orem, Corey Casper, Sam M Mbulaiteye, Kishor G Bhatia, Edus H Warren
Burkitt lymphoma (BL), the most common pediatric cancer in sub-Saharan Africa, is a malignancy of antigen-experienced B lymphocytes. High-throughput sequencing (HTS) of the immunoglobulin heavy (IGH) and light chain (IGK/IGL) loci was performed on genomic DNA from 51 primary BL tumors: 19 from Uganda and 32 from Ghana. Reverse transcription polymerase chain reaction analysis and tumor RNA sequencing (RNAseq) was performed on the Ugandan tumors to confirm and extend the findings from the HTS of tumor DNA. Clonal IGH and IGK/IGL rearrangements were identified in 41 and 46 tumors, respectively...
March 28, 2017: Blood Advances
https://www.readbyqxmd.com/read/29296767/high-throughput-sequencing-reveals-novel-features-of-immunoglobulin-gene-rearrangements-in-burkitt-lymphoma
#18
Katharine A Lombardo, David G Coffey, Alicia J Morales, Christopher S Carlson, Andrea M H Towlerton, Sarah E Gerdts, Francis K Nkrumah, Janet Neequaye, Robert J Biggar, Jackson Orem, Corey Casper, Sam M Mbulaiteye, Kishor G Bhatia, Edus H Warren
No abstract text is available yet for this article.
July 11, 2017: Blood Advances
https://www.readbyqxmd.com/read/29295031/college-students-beliefs-about-domestic-violence-a-replication-and-extension
#19
Shelly M Wagers, Jennifer Wareham, Denise Paquette Boots
In recent decades, significant effort and money have been spent to change social and legal responses to domestic violence and affect public perceptions. A small body of research has examined individuals' opinions about what behaviors are considered domestic violence. Using a sample of college students, the present study examined a modified version of a somewhat popular instrument used to measure beliefs about domestic violence, extending previous work done by Carlson and Worden. Results indicated beliefs about domestic violence are multidimensional, depending on the nature of the behavior and, in part, the gender of the perpetrator...
December 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29290170/cost-effectiveness-of-drugs-to-treat-relapsed-refractory-multiple-myeloma-in-the-united-states
#20
Josh J Carlson, Gregory F Guzauskas, Richard H Chapman, Patricia G Synnott, Shanshan Liu, Elizabeth T Russo, Steven D Pearson, Elizabeth D Brouwer, Daniel A Ollendorf
BACKGROUND: New 3-drug regimens have been developed and approved to treat multiple myeloma (MM). The absence of direct comparative data and the high cost of treatment support the need to assess the relative clinical and economic outcomes across all approved regimens. OBJECTIVE: To evaluate the cost-effectiveness of treatments for relapsed and/or refractory MM from a U.S. health system perspective. METHODS: We developed a partition survival model with 3 health states (progression-free, progression, and death) to evaluate the following regimens: carfilzomib (CFZ), elotuzumab (ELO), ixazomib (IX), daratumumab (DAR), and panobinostat (PAN) in combination with lenalidomide (LEN) or bortezomib (BOR) plus dexamethasone (DEX) in the second and/or third line of therapy...
January 2018: Journal of Managed Care & Specialty Pharmacy
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