Nikolaos Koutsouleris, Madalina-Octavia Buciuman, Clara Sophie Vetter, Clara Francesca Charlotte Weyer, Paul Zhutovsky, Santiago Tovar Perdomo, Adyasha Khuntia, Yuri Milaneschi, David Popovic, Anne Ruef, Dominic Dwyer, Katharine Chisholm, Lana Kambeitz, Linda Antonucci, Stephan Ruhrmann, Joseph Kambeitz, Anita Riecher-Rössler, Rachel Upthegrove, Raimo Salokangas, Jarmo Hietala, Christos Pantelis, Rebekka Lencer, Eva Meisenzahl, Stephen Wood, Paolo Brambilla, Stefan Borgwardt, Alessandro Bertolino, Peter Falkai
Symptom heterogeneity characterizes psychotic disorders and hinders the delineation of underlying biomarkers. Here, we identify symptom-based subtypes of recent-onset psychosis (ROP) patients from the multi-center PRONIA (Personalized Prognostic Tools for Early Psychosis Management) database and explore their multimodal biological and functional signatures. We clustered N = 328 ROP patients based on their maximum factor scores in an exploratory factor analysis on the Positive and Negative Syndrome Scale items...
March 13, 2024: Research Square