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https://www.readbyqxmd.com/read/29454121/complications-of-impulse-generator-exchange-surgery-for-deep-brain-stimulation-a-single-centre-retrospective-study
#1
Ann-Kristin Helmers, Isabel Lübbing, Falk Birkenfeld, Karsten Witt, Michael Synowitz, Hubertus Maximilian Mehdorn, Daniela Falk
OBJECTIVE: Non-rechargeable deep brain stimulation (DBS) impulse generators (IG) with a low or empty battery status require surgical IG exchange several years after initial implantation. Complication rates in patients undergoing DBS surgery range from 7.6% to 25.3%. The aim of this study was to investigate the complication rates after IG exchange surgery and to identify risk factors for complications. METHODS: We retrospectively analysed complications following IG exchange surgery from 2008 to 2015 in a single-centre university hospital setting...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29440704/blood-biomarkers-of-hikikomori-a-severe-social-withdrawal-syndrome
#2
Kohei Hayakawa, Takahiro A Kato, Motoki Watabe, Alan R Teo, Hideki Horikawa, Nobuki Kuwano, Norihiro Shimokawa, Mina Sato-Kasai, Hiroaki Kubo, Masahiro Ohgidani, Noriaki Sagata, Hiroyuki Toda, Masaru Tateno, Naotaka Shinfuku, Junji Kishimoto, Shigenobu Kanba
Hikikomori, a severe form of social withdrawal syndrome, is a growing social issue in Japan and internationally. The pathophysiology of hikikomori has not yet been elucidated and an effective treatment remains to be established. Recently, we revealed that avoidant personality disorder is the most common comorbidity of hikikomori. Thus, we have postulated that avoidant personality is the personality underpinning hikikomori. First, we herein show relationships between avoidant personality traits, blood biomarkers, hikikomori-related psychological features, and behavioural characteristics assessed by a trust game in non-hikikomori volunteers...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29438557/is-drug-induced-hepatitis-related-to-the-severity-of-tuberculous-meningitis
#3
Mritunjai Kumar, Jayantee Kalita, Abhilasha Tripathi, Usha K Misra
Background: Drug-induced hepatitis (DIH) occurs more commonly in tuberculous meningitis (TBM) than non-CNS tuberculosis. We evaluate DIH in TBM and its relationship with disease severity and surrogate markers of stress. Methods: Sixty-seven patients with TBM were included prospectively. The diagnosis of DIH was based on five times elevation of alanine amino transferase (ALT) in asymptomatic and three times in symptomatic patients, serum bilirubin 1.5 mg/dL or more occurring after 3 days of antitubercular drugs without any other cause of liver dysfunction; and improvement in liver function upon drug withdrawal...
February 9, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29437805/food-protein-induced-enterocolitis-syndrome-a-challenging-diagnosis
#4
Andreia Ribeiro, Diana Moreira, Cristina Costa, Isabel Pinto Pais
Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated gastrointestinal food hypersensitivity triggered by food proteins. It may present acutely, with repetitive vomiting, diarrhoea and lethargy leading to dehydration and eventually shock or insidiously with intermittent emesis, chronic diarrhoea or failure to thrive. We describe a paediatric male patient with recurrent sepsis-like episodes of fever, lethargy, ashen-grey skin colouration and vomiting followed by diarrhoea. These episodes were triggered by cow's milk formula and grains...
February 8, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29436729/adverse-events-linked-with-the-use-of-chimeric-and-humanized-anti-cd20-antibodies-in-children-with-idiopathic-nephrotic-syndrome
#5
Alice Bonanni, Marta Calatroni, Matteo D'Alessandro, Sara Signa, Enrica Bertelli, Michela Cioni, Eddi Di Marco, Roberto Biassoni, Gianluca Caridi, Giulia Ingrasciotta, Roberta Bertelli, Armando Di Donato, Maurizio Bruschi, Alberto Canepa, Giorgio Piaggio, Pietro Ravani, Gian Marco Ghiggeri
AIMS: Anti-CD20 antibodies are increasingly being used to treat idiopathic nephrotic syndrome (INS) in children. While they may allow steroid and calcineurin-inhibitor withdrawal, repeated infusions of anti-CD20 antibodies are often required to maintain remission. Data on their potential toxicity in INS are needed to consider repeated infusions. METHODS: We reported data on side effects related to the use of rituximab (a chimeric anti-body; 130 pts) and ofatumumab (a humanized anti-body; 37 pts) in children with INS (steroid-dependent and steroid/calcineurin-inhibitor dependent disease) treated in a national referral center during a 9-year period (400 treatments; follow-up 1-9 years)...
February 13, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29436353/feeding-infants-with-neonatal-abstinence-syndrome-finding-the-sweet-spot
#6
Denise J Maguire, Emily Shaffer-Hudkins, Kathleen Armstrong, Leah Clark
PURPOSE: The purpose of this study is to learn how caregivers who are expert in feeding infants with neonatal abstinence syndrome (NAS) successfully feed these infants during withdrawal. DESIGN/SAMPLE: Focus group methodology was used to gather information from self-identified experts from three large regional NICUs. Twelve NICU nurses and speech therapists participated in open-ended, recorded discussions. Detailed flip chart notes were taken, reviewed, and verified by the participants before the group ended...
January 1, 2018: Neonatal Network: NN
https://www.readbyqxmd.com/read/29434990/abiraterone-acetate-withdrawal-syndrome-speculations-on-the-underlying-mechanisms
#7
Tomonori Kato, Akira Komiya, Joji Yuasa, Kanya Kaga, Mayuko Kaga, Satoko Kojima, Yukio Naya, Shigeo Isaka
A 72-year-old man initially presented with lumbar and right chest pain, but was later found out to also have an elevated prostate-specific antigen (PSA) level at 2,000.0 ng/ml. Further evaluation disclosed metastatic prostate cancer involving the bones and lymph nodes. The patient was initially treated with combined androgen blockade (CAB) with leuprolide acetate and bicalutamide. After 6 months of CAB, the patient's PSA level began to rise from the nadir (85.1 ng/ml) to 113.3 ng/ml. Bicalutamide was withdrawn in anticipation of anti-androgen withdrawal syndrome and the PSA level declined temporally...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29429561/-dress-syndrome-secondary-to-pyrazinamide-an-uncommon-complication-of-tuberculosis-treatment
#8
U D Kombila, W Ka, F B R Mbaye, N F Diouf, L Fall, P Ouedraogo, A N E Koutonin, Y Dia Kane, N Oumar Toure Badiane
INTRODUCTION: The Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) is a severe drug-induced reaction. CASE REPORT: We report the case of a 35-year-old man treated by RHEZ for a first episode of a smear positive pulmonary tuberculosis and who developed a DRESS syndrome due to pyrazinamide after twenty days of treatment, associated with a viral reactivation to Human Herpes Virus 6 (HHV6). He had a skin eruption, liver involvement and hypereosinophilia...
February 8, 2018: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29419564/patient-factors-and-outcomes-associated-with-the-withdrawal-or-withholding-of-life-sustaining-therapies-in-mechanically-ventilated-brain-injured-patients-an-observational-multicentre-study
#9
Nicolas Nesseler, Antoine Roquilly, Sigismond Lasocki, Claire Dahyot-Fizelier, Yoann Launey, Cinotti Raphaël, Marine Hubert, Sonia Isslame, Pierre-François Perrigault, Thomas Geeraerts, Olivier Mimoz, Fouad Marhar, Yannick Mallédant, Fanny Feuillet, Karim Asehnoune, Philippe Seguin
BACKGROUND: Knowledge of the factors associated with the decision to withdraw or withhold life support (WWLS) in brain-injured patients is limited. However, most deaths in these patients may involve such a decision. OBJECTIVES: To identify factors associated with the decision to WWLS in brain-injured patients requiring mechanical ventilation who survive the first 24 h in the ICU, and to analyse the outcomes and time to death. DESIGN: A retrospective observational multicentre study...
February 3, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29417369/mental-health-of-mothers-of-infants-with-neonatal-abstinence-syndrome-and-prenatal-opioid-exposure
#10
Laura J Faherty, Meredith Matone, Molly Passarella, Scott Lorch
BACKGROUND: The prevalence of opioid use during pregnancy is increasing. Two downstream effects are neonatal abstinence syndrome (NAS), a postnatal withdrawal syndrome, and long-term prenatal opioid exposure (LTPOE) without documented withdrawal symptoms in the infant. Mental health characteristics of mothers of infants with NAS and LTPOE have not been described. METHODS: Using linked maternal and infant Medicaid claims and birth certificate data, we analyzed 15,571 infants born to Medicaid-insured women 15-24 years old in a mid-Atlantic city from 2007 to 2010...
February 7, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29411890/breastfeeding-and-the-substance-exposed-mother-and-baby
#11
Sonya MacVicar, Tracy Humphrey, Katrina E Forbes-McKay
BACKGROUND: Breastfeeding rates are typically low for women with a substance-use disorder. This is despite the specific benefits of breastfeeding to alleviate the severity of neonatal abstinence syndrome and the well-documented generic advantages. This study explored the feasibility of in-hospital, tailored breastfeeding support for the substance-exposed mother and baby. METHODS: This was a mixed-methods feasibility study undertaken in Scotland from April 2014 to May 2015...
February 7, 2018: Birth
https://www.readbyqxmd.com/read/29410254/successful-drug-desensitization-in-patients-with-delayed-type-allergic-reactions-to-antituberculosis-drugs
#12
Krittaecho Siripassorn, Kiat Ruxrungtham, Weerawat Manosuthi
OBJECTIVE: To evaluate the outcomes of antituberculosis drug desensitization. DESIGN: This was a retrospective study. Inclusion criteria were as follows: age >18 years, documented tuberculosis infection, a previous cutaneous allergic reaction to antituberculosis drugs, and having undergone drug desensitization between January 2003 and March 2014. Definition of allergic reactions to antituberculosis drugs included (1) a temporal relationship between drug use and allergic reaction; (2) improvement of allergic reaction after drug withdrawal; (3) recurrence of allergic reaction after reintroduction of only the offending drug; and (4) absence of other causes...
February 1, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29409548/a-clinimetric-analysis-of-a-bprs-6-scale-for-schizophrenia-severity
#13
Per Bech, Stephen F Austin, Nina Timmerby, Thomas A Ban, Stine Bjerrum Møller
OBJECTIVE: A restricted Brief Psychiatric Rating Scale (BPRS-6) with the six schizophrenia specific items from the Positive and Negative Syndrome Scale (PANSS) has been investigated. These six items from the PANSS have recently been found to have both clinical validity and 'unidimensionality' in measuring the severity of schizophrenic states. The primary objective of this study was to evaluate the clinical validity of the BPRS-6. The secondary objective was to evaluate the 'unidimensionality' of the BPRS-6 by an 'item response theory' model...
February 7, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29408090/effects-of-ralfinamide-in-models-of-nerve-injury-and-chemotherapy-induced-neuropathic-pain
#14
Xiaonan Liang, Gang Yu, Ruibin Su
Neuropathic pain is among the most common and difficult-to-treat types of chronic pain and is associated with sodium channel malfunction. The sodium channel blocker ralfinamide has exhibited potent analgesic effects in several preclinical pain models and in patients with mixed neuropathic pain syndromes (Phase II trials), but it failed to ameliorate neuropathic low back pain in Phase III trials. It is unclear whether ralfinamide is effective against neuropathic pain induced by specified etiologies. In the present study, the antinociceptive effects of ralfinamide in neuropathic pain models induced by spared nerve injury and chemotherapy were compared in a gabapentin-controlled manner...
January 30, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29404508/sofosbuvir-induced-steven-johnson-syndrome-in-a-patient-with-hepatitis-c-virus-related-cirrhosis
#15
Nipun Verma, Shreya Singh, Gitesh Sawatkar, Virendra Singh
Sofosbuvir is an imperative drug used in treatment regimens for hepatitis C virus (HCV). It is considered relatively safe with fewer adverse effects than other treatments. Here, we report a rare and potentially serious, dermatologic, adverse effect following the use of sofosbuvir. A 35-year-old man with genotype 3-related HCV cirrhosis presented with decompensated ascites and jaundice following 7 weeks of therapy with peginterferon alpha-2a and oral ribavirin. After peginterferon withdrawal and stabilization, oral sofosbuvir and ribavirin were started; 10 days later, he developed itching over the trunk and legs, followed by multiple papules and vesicles over an erythematous base...
January 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29395672/dok7-myasthenic-syndrome-with-subacute-adult-onset-during-pregnancy-and-partial-response-to-fluoxetine
#16
Mariana Santos, Simão Cruz, João Peres, Luís Santos, Purificação Tavares, Jorge Pinto Basto, Vasco Salgado, Ana Herrero Valverde
DOK7 congenital myasthenic syndrome (DOK7-CMS) generally presents early in life and is treated with salbutamol or ephedrine. This report describes an atypical case of a 39-year-old woman who presented with proximal upper limb weakness in the third trimester of pregnancy and was initially diagnosed with seronegative myasthenia gravis. Dramatic clinical worsening under pyridostigmine and further inefficacy of steroids, intravenous human immunoglobulin (IVIG) and plasma exchange (PLEX) led to the presumptive diagnosis of a CMS...
December 13, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/29392226/acute-pain-management-in-patients-with-drug-dependence-syndrome
#17
Jane Quinlan, Felicia Cox
Managing patients with dependence requires knowledge of pharmacology; an understanding of the diagnosis of dependence and recognition of withdrawal; skills in communication and collaborative working; and a nonjudgmental, empathic attitude.
July 2017: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29391826/spotlight-on-naldemedine-in-the-treatment-of-opioid-induced-constipation-in-adult-patients-with-chronic-noncancer-pain-design-development-and-place-in-therapy
#18
REVIEW
Emily K Stern, Darren M Brenner
Opioid-induced constipation (OIC) is an increasingly prevalent problem in the USA due to the growing use of opioids. A novel class of therapeutics, the peripherally acting μ-opioid receptor antagonists (PAMORAs), has been developed to mitigate the deleterious effects of opioids in the gastrointestinal tract while maintaining central analgesia and minimizing opioid withdrawal. This review aimed to summarize the literature on naldemedine, the third PAMORA to gain US Food and Drug Administration (FDA) approval for the treatment of OIC in adults with chronic noncancer pain-related syndromes...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29391756/effect-of-lactobacillus-rhamnosus-gg-supernatant-on-serotonin-transporter-expression-in-rats-with-post-infectious-irritable-bowel-syndrome
#19
Ya-Nan Cao, Li-Juan Feng, Yuan-Yuan Liu, Kui Jiang, Mao-Jun Zhang, Yi-Xin Gu, Bang-Mao Wang, Jia Gao, Ze-Lan Wang, Yu-Ming Wang
AIM: To evaluate the effect of Lactobacillus rhamnosus GG supernatant (LGG-s) on the expression of serotonin transporter (SERT) in rats with post-infectious irritable bowel syndrome (PI-IBS). METHODS: Campylobacter jejuni 81-176 (1010 CFU/mL) was used to induce intestinal infection to develop a PI-IBS model. After evaluation of the post-infectious phase by biochemical tests, DNA agarose gel electrophoresis, abdominal withdrawal reflex (AWR) test, and the intestinal motility test, four PI-IBS groups received different concentrations of LGG-s for 4 wk...
January 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29390523/efficacy-of-eculizumab-in-an-adult-patient-with-hiv-associated-hemolytic-uremic-syndrome-a-case-report
#20
Marine Freist, Cyril Garrouste, Nora Szlavik, Paul Coppo, Alexandre Lautrette, Anne Elisabeth Heng
INTRODUCTION: Hemolytic uremic syndrome (HUS) in Human Immunodeficiency Virus (HIV)-positive patients has become a rare cause of kidney injury since the era of highly active antiretroviral therapy (HAART). Plasma exchange and antiretroviral therapy were previously recommended but often failed to achieve remission. We report a case of HUS in a HIV-positive patient treated successfully with eculizumab. CASE SUMMARY: A 52-year-old woman presented to hospital with acute renal failure, thrombocytopenia, anemia, and hypoxemia...
December 2017: Medicine (Baltimore)
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