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https://www.readbyqxmd.com/read/28735193/fabrication-of-in2s3-zn2geo4-composite-photocatalyst-for-degradation-of-acetaminophen-under-visible-light
#1
Tao Yan, Tingting Wu, Yaru Zhang, Meng Sun, Xiaodong Wang, Qin Wei, Bin Du
A novel indium trisulfide/zinc germinate (In2S3/Zn2GeO4) composite was developed via a co-precipitation hydrothermal method. The as-prepared composite was characterized in detail by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and UV-vis diffuse reflectance spectroscopy (DRS). Zn2GeO4 nanorods work as the main photocatalyst while In2S3 nanoparticles deposited on them acts as the photosensitizer. The resulting In2S3/Zn2GeO4 heterogeneous photocatalyst not only has enhanced visible light absorption, but also improved photo-generated charge transfer efficiency with remarkably high efficiency in decomposing acetaminophen (APAP)...
June 23, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28734286/communication-light-driven-remote-control-of-microgels-size-in-the-presence-of-photosensitive-surfactant-complete-phase-diagram
#2
Selina Schimka, Yulia D Gordievskaya, Nino Lomadze, Maren Lehmann, Regine von Klitzing, Artem M Rumyantsev, Elena Yu Kramarenko, Svetlana Santer
Here we report on a light triggered remote control of microgel size in the presence of photosensitive surfactant. The hydrophobic tail of the cationic surfactant contains azobenzene group that undergoes a reversible photo-isomerization reaction from a trans- to a cis-state accompanied by a change in the hydrophobicity of the surfactant. We have investigated light assisted behaviour and the complex formation of the microgels with azobenzene containing surfactant over the broad concentrational range starting far below and exceeding several times of the critical micelle concentration (CMC)...
July 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28733761/spontaneous-photosensitization-by-heterophyllaea-pustulata-hook-f-rubiaceae-in-sheep-from-northwestern-argentina
#3
J F Micheloud, L A Colque-Caro, L R Comini, J L Cabrera, S Núñez-Montoya, O G Martinez, E J Gimeno
Heterophyllaea pustulata Hook. f. (Rubiaceae) is a phototoxic plant. It grows in the Andean area of northwest of Argentina, and it causes significant economic losses in the livestock. This plant induces dermal lesions by photosensitization probably due to its content of photosensitizing anthraquinones. This paper describes an outbreak of poisoning in Corriedale sheepfold, which had an incidence of 49%. Ear skin biopsies and blood samples were collected of six affected animals. Liver enzymes remained within the reference limits...
July 21, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28732259/dravet-syndrome-characteristics-comorbidities-and-caregiver-concerns
#4
Nicole Villas, Mary Anne Meskis, Sue Goodliffe
The Dravet Syndrome Foundation (DSF) conducted the largest in-depth survey of parents and caregivers of patients with Dravet syndrome (DS) to date, in order to (1) identify top concerns among caregivers, (2) establish an approximate frequency of characteristics and comorbidities of DS beyond seizures, and (3) provide direction for clinicians and researchers looking to study the effects of DS on the patient and family unit. Two hundred fifty-six responses were received representing a patient age range of 9months to 32years with a median age group of 7-10years (IQR=8)...
July 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28732060/formation-of-singlet-oxygen-by-decomposition-of-protein-hydroperoxide-in-photosystem-ii
#5
Vinay Pathak, Ankush Prasad, Pavel Pospíšil
Singlet oxygen (1O2) is formed by triplet-triplet energy transfer from triplet chlorophyll to O2 via Type II photosensitization reaction in photosystem II (PSII). Formation of triplet chlorophyll is associated with the change in spin state of the excited electron and recombination of triplet radical pair in the PSII antenna complex and reaction center, respectively. Here, we have provided evidence for the formation of 1O2 by decomposition of protein hydroperoxide in PSII membranes deprived of Mn4O5Ca complex...
2017: PloS One
https://www.readbyqxmd.com/read/28731112/carrier-free-self-assembled-pure-drug-nanorods-composed-of-10-hydroxycamptothecin-and-chlorin-e6-for-combinatorial-chemo-photodynamic-antitumor-therapy-in-vivo
#6
Yan Wen, Wei Zhang, Ningqiang Gong, Yi-Feng Wang, Hong-Bo Guo, Weisheng Guo, Paul C Wang, Xing-Jie Liang
Carrier-free nanodrugs formulated from the supramolecular self-assembly of pure drug molecules have emerged as an innovative and promising strategy for tumor therapy. We report herein a new and simple method to directly assemble a small hydrophobic anticancer drug, 10-hydroxycamptothecin (HCPT), with a photosensitizer chlorin e6 (Ce6) to form stable, discrete nanorods (NRs), which not only circumvent the extreme hydrophobicity of HCPT but also incorporate two different modalities into one delivery system for combination therapy...
July 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28730961/novel-fluorinated-porphyrins-sensitize-tumor-cells-to-photodamage-in-normoxia-and-hypoxia-synthesis-and-biocompatible-formulations
#7
Elizaveta V Belyaeva, Alina A Markova, Dmitry N Kaluzhnyb, Andrei L Sigan, Lev L Gervitz, Aida N Ataeva, Nikolai D Chkanikov, Alexander A Shtil
: Background. Hypoxia renders tumor cells refractory to treatment. One way to overcome this problem is the design of drug delivery systems that contain the antitumor agent within an oxygen supply medium. OBJECTIVE: to evaluate whether the perfluorocarbon liquids (capable of retaining up to 50% v/v amounts of O2 gas) can be tools for delivery of photosensitizers to hypoxic tumors. METHOD: We synthesized a series of compounds in which fluoroaliphatic or fluoroaromatic moieties were conjugated to the porphyrin ring in meso-positions...
July 19, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28730196/photosensitization-mechanism-of-cu-ii-porphyrins
#8
Jon Uranga, Jon M Matxain, Xabier Lopez, Jesus M Ugalde, David Casanova
This work presents the mechanism of the photoinduced generation of reactive oxygen species (ROS) by paramagnetic copper porphyrins in aqueous solution. Electronic structure calculations within the framework of the (time-dependent) density functional theory, (TD)DFT, reveal the details regarding the development of the atomistic and electronic structures of the copper porphyrin in solution along the set of chemical reactions accessible upon photoactivation. This study identifies the key parameters controlling the feasibility of the various reaction pathways that drive the formation of specific reactive oxygen species, ROS, i...
July 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28730194/covalent-hybrids-based-on-re-i-tricarbonyl-complexes-and-polypyridine-functionalized-polyoxometalate-synthesis-characterization-and-electronic-properties
#9
Thomas Auvray, Marie-Pierre Santoni, Bernold Hasenknopf, Garry S Hanan
A series of [Re(CO)3Br(N^N)] (N^N = substituted 2,2'-bipyridine ligand) complexes based on polypyridine-functionalized Dawson polyoxometalate (1-3) has been synthesized. The new hybrids (4-6) were characterized by various analytical techniques, including absorption, vibrational and luminescence spectroscopies as well as electrochemistry. Both units, the polyoxometalate and the transition metal complex, retain their intrinsic properties. Their combination in the newly prepared hybrids results in improved photosensitization in the high-energy visible region...
July 21, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28730123/iprgcs-possible-causation-accounts-for-the-higher-prevalence-of-sleep-disorders-in-glaucoma-patients
#10
Zhen-Zhen Guo, Shan-Ming Jiang, Li-Ping Zeng, Li Tang, Ni Li, Zhu-Ping Xu, Xin Wei
Sleep accounts for a third of one's lifetime, partial or complete deprivation of sleep could elicit sever disorders of body function. Previous studies have reported the higher prevalence of sleep disorders in glaucoma patients, but the definite mechanism for this phenomenon is unknown. On the other hand, it is well known by us that the intrinsically photosensitive retinal ganglion cells (ipRGCs) serve additional ocular functions, called non-image-forming (NIF) functions, in the regulation of circadian rhythm, melatonin secretion, sleep, mood and others...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28729017/daily-levels-and-rhythm-in-circulating-corticosterone-and-insulin-are-altered-with-photostimulated-seasonal-states-in-night-migratory-blackheaded-buntings
#11
Ila Mishra, Devraj Singh, Vinod Kumar
The circadian rhythms are involved in the photostimulation of seasonal responses in migratory blackheaded buntings. Here, we investigated whether changes in daily levels and rhythm in corticosterone (cort) and insulin secretions were associated with transitions in the photoperiodic seasonal states. Buntings were exposed to short days to maintain the winter (photosensitive) non-migratory state, and to long days for varying durations to induce the premigratory, migratory (shown by migratory restlessness at night, Zugunruhe) and summer non-migratory (photorefractory) states...
July 17, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28727420/bio-inspired-development-of-p-st-maa-avermectins-nanoparticles-with-high-affinity-for-foliage-to-enhance-folia-retention
#12
Jie Liang, Manli Yu, Liya Guo, Bo Cui, Xiang Zhao, Changjiao Sun, Yan Wang, Guoqiang Liu, Haixin Cui, Zhanghua Zeng
Pesticides are chemical or biological substances to control pests and protect crop yield. Most pesticides suffering from large amounts of losses in the environment, lead to damage of ecological systems and food pollution. To reduce their losses and increase utilization rate, we have developed a bio-inspired by mussel avermectins nanoparticles (P(St-MAA)-Av-Cat) with strong adhesion to crop foliage by emulsion-solvent evaporation method and chemical modification. They were near spheres sharpness with a diameter around 120 nm...
July 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28726870/highly-efficient-photosensitizers-with-aggregation-induced-emission-characteristics-obtained-through-precise-molecular-design
#13
Shidang Xu, Wenbo Wu, Xiaolei Cai, Chong-Jing Zhang, Youyong Yuan, Jing Liang, Guangxue Feng, Purnima Manghnani, Bin Liu
We herein report a new strategy to obtain highly efficient photosensitizers (PSs) by reducing the singlet-triplet energy gap (ΔEST) and blocking the non-radiative decay pathways. Through precise molecular design, TP1-8 were synthesized to exhibit predictable properties including moderate to high photosensitizing efficacy, tunable absorption and emission wavelengths and aggregation-induced emission characteristics.
July 20, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28725533/controllable-photodynamic-therapy-implemented-by-regulating-singlet-oxygen-efficiency
#14
REVIEW
Wenting Wu, Xiaodong Shao, Jianzhang Zhao, Mingbo Wu
With singlet oxygen ((1)O2) as the active agent, photodynamic therapy (PDT) is a promising technique for the treatment of various tumors and cancers. But it is hampered by the poor selectivity of most traditional photosensitizers (PS). In this review, we present a summary of controllable PDT implemented by regulating singlet oxygen efficiency. Herein, various controllable PDT strategies based on different initiating conditions (such as pH, light, H2O2 and so on) have been summarized and introduced. More importantly, the action mechanisms of controllable PDT strategies, such as photoinduced electron transfer (PET), fluorescence resonance energy transfer (FRET), intramolecular charge transfer (ICT) and some physical/chemical means (e...
July 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28723923/on-the-mechanism-of-candida-tropicalis-biofilm-reduction-by-the-combined-action-of-naturally-occurring-anthraquinones-and-blue-light
#15
Juliana Marioni, Roger Bresolí-Obach, Montserrat Agut, Laura R Comini, José L Cabrera, María G Paraje, Santi Nonell, Susana C Núñez Montoya
The photoprocesses involved in the photo-induced Candida tropicalis biofilm reduction by two natural anthraquinones (AQs), rubiadin (1) and rubiadin-1-methyl ether (2), were examined. Production of singlet oxygen (1O2) and of superoxide radical anion (O2•-) was studied. Although it was not possible to detect the triplet state absorption of any AQs in biofilms, observation of 1O2 phosphorescence incubated with deuterated Phosphate Buffer Solution, indicated that this species is actually formed in biofilms...
2017: PloS One
https://www.readbyqxmd.com/read/28723895/visible-light-driven-methane-formation-from-co2-with-a-molecular-iron-catalyst
#16
Heng Rao, Luciana C Schmidt, Julien Bonin, Marc Robert
Converting CO2 into fuel or chemical feedstock compounds could in principle reduce fossil fuel consumption and climate-changing CO2 emissions. One strategy aims for electrochemical conversions powered by electricity from renewable sources, but photochemical approaches driven by sunlight are also conceivable. A considerable challenge in both approaches is the development of efficient and selective catalysts, ideally based on cheap and Earth-abundant elements rather than expensive precious metals. Of the molecular photo- and electrocatalysts reported, only a few catalysts are stable and selective for CO2 reduction; moreover, these catalysts produce primarily CO or HCOOH, and catalysts capable of generating even low to moderate yields of highly reduced hydrocarbons remain rare...
July 17, 2017: Nature
https://www.readbyqxmd.com/read/28722126/investigating-the-effect-of-poly-l-lactic-acid-nanoparticles-carrying-hypericin-on-the-flow-biased-diffusive-motion-of-hela-cell-organelles
#17
Rozhin Penjweini, Sarah Deville, Omid Haji Maghsoudi, Kristof Notelaers, Anitha Ethirajan, Marcel Ameloot
OBJECTIVES: In this study, we investigate in human cervical epithelial HeLa cells the intracellular dynamics and the mutual interaction with the organelles of the poly-l-lactic acid nanoparticles (PLLA NPs) carrying the naturally occurring hydrophobic photosensitizer hypericin. METHODS: Temporal and spatiotemporal image correlation spectroscopy was used for the assessment of the intracellular diffusion and directed motion of the nanocarriers by tracking the hypericin fluorescence...
July 19, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28721930/pharmacoresistant-epileptic-eyelid-twitching-in-a-child-with-a-mutation-in-syngap1
#18
Tetsuya Okazaki, Yoshiaki Saito, Rika Hiraiwa, Shinji Saitoh, Masachika Kai, Kaori Adachi, Yoko Nishimura, Eiji Nanba, Yoshihiro Maegaki
SYNGAP1 gene mutation has been associated with epilepsy which is often drug resistant, with seizure types including eyelid myoclonia. However, detailed descriptions, including ictal video-EEG, have not been reported. We report the case of a 4-year-old boy who developed recurrent epileptic eyelid twitching at 1 year and 5 months of age. Seizures gradually increased in frequency to more than 50 times per day and manifested with upward eye deviation, motion arrest, loss of consciousness, and eyelid twitching lasting for five seconds...
July 19, 2017: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/28717198/controlled-modification-of-biomolecules-by-ultrashort-laser-pulses-in-polar-liquids
#19
Vitaly Gruzdev, Dmitry Korkin, Brian P Mooney, Jesper F Havelund, Ian Max Møller, Jay J Thelen
Targeted chemical modification of peptides and proteins by laser pulses in a biologically relevant environment, i.e. aqueous solvent at room temperature, allows for accurate control of biological processes. However, the traditional laser methods of control of chemical reactions are applicable only to a small class of photosensitive biomolecules because of strong and ultrafast perturbations from biomolecule-solvent interactions. Here, we report excitation of harmonics of vibration modes of solvent molecules by femtosecond laser pulses to produce controlled chemical modifications of non-photosensitive peptides and proteins in polar liquids under room conditions...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28716739/phototoxicity-in-a-laryngeal-cancer-cell-line-enhanced-by-a-targeting-amphiphilic-chlorin-photosensitizer
#20
Milene N O Moritz, Carlos Rossa, Kleber T de Oliveira, Marciana P Uliana, Janice R Perussi
BACKGROUND: Photodynamic therapy (PDT) has been established in several countries as an alternative therapy for the treatment of various malignancies. This therapy involves the incorporation of a photosensitizer (PS) that is activated by visible light and form reactive oxygen species leading to target cell death by apoptosis or necrosis. Previously, our group has demonstrated that CHL-T (semi-synthesized from chlorophyll a and containing a linked solubilizing group TRISMA(®)) presented a pronounced potential to induce death in HeLa cell line after PDT...
July 14, 2017: Photodiagnosis and Photodynamic Therapy
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