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https://www.readbyqxmd.com/read/29056528/shipment-of-a-photodynamic-therapy-agent-into-model-membrane-and-its-controlled-release-a-photophysical-approach
#1
Monaj Karar, Suvendu Paul, Arabinda Mallick, Tapas Majumdar
Harmine, an efficient cancer cell photosensitizer (PS), emits intense violet color when it is incorporated in well established self assembly based drug carrier formed by cationic surfactants of identical positive charge of head group but varying chain length, namely, dodecyltrimethylammonium bromide (DTAB), tetradecyltrimethylammonium bromide (TTAB) and cetyltrimethylammonium bromide (CTAB). Micelle entrapped drug emits in the UV region when it interacts with non-toxic β-cyclodextrin (β-CD). Inspired by these unique fluorescence/structural switching properties of the anticancer drug, in the present work we have monitored the interplay of the drug between micelles and non-toxic β-CDs...
October 19, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/29055734/development-of-copolymeric-nanoparticles-of-hypocrellin-b-enhanced-phototoxic-effect-and-ocular-distribution
#2
Venkateshwaran Krishnaswami, Chandrasekar Ponnusamy, Senthilkumar Sankareswaran, Muthuselvam Paulsamy, Madi Madiyalakan, Rajaguru Palanisamy, Ruckmani Kandasamy, Subramanian Natesan
In the present work, we have developed a photosensitizer hypocrellin B (HB) and nano silver loaded PLGA-TPGS nanoparticles with improved singlet oxygen production for enhanced photodynamic effect for the efficient treatment of age related macular degeneration. Random copolymer (PLGA-TPGS) synthesized by ring opening and bulk polymerization was characterized by IR, (1)H NMR and TGA analysis. HBS-CP-NPs prepared by nanoprecipitation techniques were spherical shaped 89.6-753.6nm size particles with negative zeta potential...
October 18, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29054711/high-throughput-photo-oxidations-in-a-packed-bed-reactor-system
#3
Caleb J Kong, Daniel Fisher, Bimbisar K Desai, Yuan Yang, Saeed Ahmad, Katherine Belecki, B Frank Gupton
The efficiency gains produced by continuous-flow systems in conducting photochemical transformations have been extensively demonstrated. Recently, these systems have been used in developing safe and efficient methods for photo-oxidations using singlet oxygen generated by photosensitizers. Much of the previous work has focused on the use of homogeneous photocatalysts. The development of a unique, packed-bed photoreactor system using immobilized rose bengal expands these capabilities as this robust photocatalyst allows access to and elaboration from these highly useful building blocks without the need for further purification...
July 6, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29053580/study-of-the-photodynamic-activity-of-n-doped-tio%C3%A2-nanoparticles-conjugated-with-aluminum-phthalocyanine
#4
Xiaobo Pan, Xinyue Liang, Longfang Yao, Xinyi Wang, Yueyue Jing, Jiong Ma, Yiyan Fei, Li Chen, Lan Mi
TiO₂ nanoparticles modified with phthalocyanines (Pc) have been proven to be a potential photosensitizer in the application of photodynamic therapy (PDT). However, the generation of reactive oxygen species (ROS) by TiO₂ nanoparticles modified with Pc has not been demonstrated clearly. In this study, nitrogen-doped TiO₂ conjugated with Pc (N-TiO₂-Pc) were studied by means of monitoring the generation of ROS. The absorbance and photokilling effect on HeLa cells upon visible light of different regions were also studied and compared with non-doped TiO₂-Pc and Pc...
October 20, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29053273/distinguishing-nitro-vs-nitrito-coordination-in-cytochrome-c-using-vibrational-spectroscopy-and-density-functional-theory
#5
Zach N Nilsson, Brian L Mandella, Kakali Sen, Demet Kekilli, Michael A Hough, Pierre Moënne-Loccoz, Richard W Strange, Colin R Andrew
Nitrite coordination to heme cofactors is a key step in the anaerobic production of the signaling molecule nitric oxide (NO). An ambidentate ligand, nitrite has the potential to coordinate via the N- (nitro) or O- (nitrito) atoms in a manner that can direct its reactivity. Distinguishing nitro vs nitrito coordination, along with the influence of the surrounding protein, is therefore of particular interest. In this study, we probed Fe(III) heme-nitrite coordination in Alcaligenes xylosoxidans cytochrome c' (AXCP), an NO carrier that excludes anions in its native state but that readily binds nitrite (Kd ∼ 0...
October 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29052049/photophysicochemical-calf-thymus-dna-binding-and-in-vitro-photocytotoxicity-properties-of-tetra-morpholinoethoxy-substituted-phthalocyanines-and-their-water-soluble-quaternized-derivatives
#6
Halit Koçan, Kerem Kaya, İbrahim Özçeşmeci, B Şebnem Sesalan, Meltem Göksel, Mahmut Durmuş, Ayfer Kalkan Burat
In this study, morpholinoethoxy-substituted metal-free (3), zinc(II) (4) and indium(III) (5) phthalocyanines were synthesized. These phthalocyanines were converted to their water-soluble quaternized derivatives (3Q-5Q) using excess methyl iodide as a quaternization agent. All these phthalocyanines (Pcs) were characterized by elemental analysis and different spectroscopic methods such as FT-IR, (1)H NMR, UV-Vis and mass spectrometry. The photophysical and photochemical properties such as fluorescence and generation of singlet oxygen were investigated for determination of these phthalocyanines as photosensitizers in photodynamic therapy (PDT) applications...
October 19, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29051945/cancer-classification-with-a-network-of-chemical-oscillators
#7
Konrad Gizynski, Jerzy Gorecki
We discuss chemical information processing considering dataset classifiers formed with a network of interacting droplets. Our arguments are based on computer simulations of droplets in which a photosensitive variant of the Belousov-Zhabotinsky (BZ) reaction proceeds. By applying optical control we can adjust the time evolution of individual droplets and prepare the network to perform a specific computational task. We demonstrate that chemical classifiers made of droplets can be designed in computer simulations based on evolutionary algorithms...
October 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29051123/knowledge-behavior-and-attitudes-of-dental-practitioners-towards-photodynamic-therapy-use-in-dental-practice
#8
Fahim Vohra, Ishfaq A Bukhari, Saeed A Sheikh, Refal Albaijan, Abdul Hakeem Qureshi, Zaeem Arif, Zohaib Akram
BACKGROUND: The aim of the present study was to assess knowledge, behavior and attitudes of dental practitioners (DPs) towards photodynamic therapy (PDT) in dental clinical practice. METHODS: A cross-sectional study was performed and a 13-item survey questionnaire was given to DPs practicing in 13 different teaching hospitals in Karachi, Pakistan. Questions were aimed at exploring the knowledge of DPs regarding PDT and their attitude towards PDT and perceptions that may influence clinical practices...
October 16, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29050884/initial-digital-vasculitis-in-a-large-multicenter-cohort-of-childhood-onset-systemic-lupus-erythematosus
#9
Ana Paula Sakamoto, Clovis Artur Silva, Marco Felipe Castro da Silva, Anandreia Simões Lopes, Gleice Clemente Souza Russo, Adriana Maluf Elias Sallum, Katia Kozu, Eloisa Bonfá, Claudia Saad-Magalhães, Rosa Maria Rodrigues Pereira, Claudio Arnaldo Len, Maria Teresa Terreri
OBJECTIVES: To assess clinical digital vasculitis (DV) as an initial manifestation of childhood-onset systemic lupus erythematosus (cSLE) within a large population. METHODS: Multicenter cross-sectional study including 852 cSLE patients (ACR criteria) followed in ten Pediatric Rheumatology centers in São Paulo State, Brazil. RESULTS: DV was observed in 25/852 (3%) cSLE patients. Periungual hemorrhage was diagnosed in 12 (48%), periungual infarction in 7 (28%), tip finger ulceration in 4 (16%), painful nodules in 1 (4%) and gangrene in 1 (4%)...
October 16, 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/29050826/live-cell-time-lapse-imaging-and-single-cell-tracking-of-in-vitro-cultured-neural-stem-cells-tools-for-analyzing-dynamics-of-cell-cycle-migration-and-lineage-selection
#10
Katja M Piltti, Brian J Cummings, Krystal Carta, Ayla Manughian-Peter, Colleen Worne, Kulbir Singh, Danier Ong, Yuriy Maksymyuk, Michelle Khine, Aileen J Anderson
Neural stem cell (NSC) cultures have been considered technically challenging for time-lapse analysis due to high motility, photosensitivity, and growth at confluent densities. We have tested feasibility of long-term live-cell time-lapse analysis for NSC migration and differentiation studies. Here, we describe a method to study the dynamics of cell cycle, migration, and lineage selection in cultured multipotent mouse or human NSCs using single-cell tracking during a long-term, 7-14 day live-cell time-lapse analysis...
October 16, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29049724/patients-with-normal-tension-glaucoma-have-relative-sparing-of-the-relative-afferent-pupillary-defect-compared-to-those-with-open-angle-glaucoma-and-elevated-intraocular-pressure
#11
Mitchell Lawlor, Ana Quartilho, Catey Bunce, Neil Nathwani, Emily Dowse, Debbie Kamal, Gus Gazzard
Purpose: We determined whether there is relative sparing of pupil function in glaucoma patients with normal pressures compared to those with high pressures. Methods: A cross-sectional study was done of 68 patients with primary open angle glaucoma (POAG): 38 had normal IOPs on all-day phasing before treatment (never >21 mm Hg), with confirmed progression of glaucomatous optic neuropathy (NTG) and 30 had glaucomatous optic neuropathy associated with elevated intraocular pressures (>25 mm Hg; HP-POAG)...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29048645/establishment-and-characterization-of-human-osteosarcoma-cells-resistant-to-pyropheophorbide-%C3%AE-methyl-ester-mediated-photodynamic-therapy
#12
Yong Tao, Yunsheng Ou, Hang Yin, Yanyang Chen, Shenxi Zhong, Yongjian Gao, Zenghui Zhao, Bin He, Qiu Huang, Qianxing Deng
The present study was performed to establish and characterize new human osteosarcoma cell lines resistant to pyropheophorbide-α methyl ester‑mediated photodynamic therapy (MPPa-PDT). MPPa-PDT-resistant cells are isolated from the human osteosarcoma MG63 and HOS cell lines and two resistant populations were finally acquired, including MG63/PDT and HOS/PDT. Cell Counting Kit-8 (CCK-8) assay was used to determine the MPPa-PDT, cisplatin (CDDP) resistance and proliferation of MG63, MG63/PDT, HOS and HOS/PDT cells...
September 27, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29048169/photoactivity-of-new-octacationic-magnesium-ii-and-zinc-ii-porphyrazines-in-a-water-solution-and-g-quadruplex-binding-ability-of-differently-sized-zinc-ii-porphyrazines
#13
Fabiola Sciscione, Francesco Manoli, Elisa Viola, Jitendra Wankar, Claudio Ercolani, Maria Pia Donzello, Ilse Manet
The new octacations [(2-Mepy)8PzM](8+) [M = Mg(II)(H2O), Zn(II)], isolated as iodide salts, were obtained from the corresponding neutral complexes [Py8PzM] (Py = 2-pyridyl; Pz = porphyrazinato dianion) upon quaternization with CH3I of the N atoms of the 2-pyridyl rings under mild experimental conditions. The absorption spectra registered in organic solvents as well as in water (H2O) confirm the presence of the complexes in their monomeric form in all cases. The two octacations behave as photosensitizers in a H2O/sodium dodecyl sulfate solution for the production of singlet oxygen, (1)O2, and exhibit quantum yield values (ΦΔ) 2...
October 19, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29047775/selective-photo-oxidation-induced-bi-periodic-plasmonic-structures-for-high-density-data-storage
#14
Xiuxiu Han, Shencheng Fu, Xintong Zhang, Shuang Lu, Shuangyan Liu, Xinnong Wang, Ruiya Ji, Xiuli Wang, Yichun Liu, Jinhuan Li
Stable and controllable optical memory is necessary for the development of current information technology. In this context, Ag/TiO2 films have received much attention for their photosensitivity in wavelength and polarization, which can be applied to high-density optical storage. Here, we carried out dual-wavelength holographic recording using 403.4 nm and 532 nm lasers, and obtained mixed microfringes based on selective photodissolution of Ag nanoparticles of various sizes in TiO2 nanoporous films. Two recording methods of simultaneous and sequential multiplexing were investigated...
October 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047228/organoiridium-photosensitizers-induce-specific-oxidative-attack-on-proteins-within-cancer-cells
#15
Pingyu Zhang, Cookson K C Chiu, Huaiyi Huang, Yuko P Y Lam, Abraha Habtemariam, Thomas Malcomson, Martin J Paterson, Guy J Clarkson, Peter B O'Connor, Hui Chao, Peter J Sadler
Strongly luminescent iridium(III) complexes, [Ir(C,N)2 (S,S)](+) (1) and [Ir(C,N)2 (O,O)] (2), containing C,N (phenylquinoline), O,O (diketonate), or S,S (dithione) chelating ligands, have been characterized by X-ray crystallography and DFT calculations. Their long phosphorescence lifetimes in living cancer cells give rise to high quantum yields for the generation of (1) O2 , with large 2-photon absorption cross-sections. 2 is nontoxic to cells, but potently cytotoxic to cancer cells upon brief irradiation with low doses of visible light, and potent at sub-micromolar doses towards 3D multicellular tumor spheroids with 2-photon red light...
October 19, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29046834/application-of-visible-light-photosensitization-to-form-alkyl-radical-derived-thin-films-on-gold
#16
Rashanique D Quarels, Xianglin Zhai, Neepa Kuruppu, Jenny K Hedlund, Ashley A Ellsworth, Amy V Walker, Jayne C Garno, Justin R Ragains
Visible-light irradiation of phthalimide esters in the presence of the photosensitizer [Ru(bpy)3](2+) and the stoichiometric reducing agent benzyl nicotinamide results in the formation of alkyl radicals under mild conditions. This approach to radical generation has proven useful for the synthesis of small organic molecules. Herein, we demonstrate for the first time the visible-light photosensitized deposition of robust alkyl thin films on Au surfaces using phthalimide esters as the alkyl radical precursors...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/29045964/-increased-serum-c-c-chemokine-ligand-19-levels-correlated-with-b-cell-abnormalities-in-systemic-lupus-erythematosus
#17
H J Liu, L J Shi, F L Hu, H H Yao, Z G Li, Y Jia
OBJECTIVE: To detect the levels of serum C-C chemokine ligand 19 (CCL19) in patients with systemic lupus erythematosus (SLE) and to evaluate the correlation between CCL19 expression and clinical features and laboratory parameters, trying to reveal the possible role of CCL19 in the pathogenesis of systemic lupus erythematosus. METHODS: The levels of serum CCL19 were measured by enzyme linked immunosorbent assay (ELISA) in 90 patients with SLE and 30 healthy controls...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29045918/cervical-cancer-cells-hela-response-to-photodynamic-therapy-using-a-zinc-phthalocyanine-photosensitizer
#18
Natasha Hodgkinson, Cherie Ann Kruger, Mpho Mokwena, Heidi Abrahamse
Cervical cancer is the most common gynecological malignancy worldwide, and the leading cause of cancer related deaths among females. Conventional treatment for early cervical cancer is radical hysterectomy. In locally advanced cancer the treatment of choice is concurrent chemo radiation. Although such treatment methods show promise, they do have adverse side effects. To minimize these effects, as well as prevent cancer re-occurrence, new treatment methods are being investigated. Photodynamic therapy (PDT) involves the selective uptake of a photosensitizer (PS) by cancer cells, illumination with light of an appropriate wavelength that triggers a photochemical reaction leading to the generation of reactive oxygen and subsequent tumor regression...
October 4, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29045251/novel-endoscopic-visualization-techniques-for-bladder-cancer-detection-a-review-of-the-contemporary-literature
#19
Andrea Mari, Mohammad Abufaraj, Killian M Gust, Shahrokh F Shariat
PURPOSE OF REVIEW: To describe the principles of photodynamic diagnosis (PDD), narrow-band imaging (NBI) and Storz Professional Image Enhancement System (SPIES) techniques for the endoscopic management of nonmuscle-invasive bladder cancer (BCa) and to report their impact on clinical practice. RECENT FINDINGS: PDD is associated with an increased sensitivity for detecting BCa specifically carcinoma in situ (CIS). Moreover, PDD has been shown to lower recurrence rate in comparison with white-light cystoscopy...
October 17, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/29044839/electro-and-photocatalytic-generation-of-h2-using-a-distinctive-co-ii-pn3p-pincer-supported-complex-with-water-or-saturated-saline-as-a-hydrogen-source
#20
Gyandshwar Kumar Rao, Wendy Pell, Bulat Gabidullin, Ilia Korobkov, Darrin Richeson
Efficient electrocatalytic production of H2 from mixed water/acetonitrile solutions was achieved using three new Co(II) complexes supported by the neutral pincer ligand bis(diphenylphosphino)-2,6-di(methylamino)pyridine ("PN3P"). At 1.9 V vs Fc/Fc+, these catalysts showed 96% Faradaic efficiency with added water or saturated aqueous saline at rates of up to 316 L(mol cat)-1(cm2)-1h-1 using a glassy carbon working electrode. The complex [Co(3-2,6-{Ph2PNMe}2(NC5H3)Br2] (1) was also able to photocatalytically reduce water to hydrogen in the presence of a Ru(bpy)32+ photosensitizer and a reductant...
October 17, 2017: Chemistry: a European Journal
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