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Nirveek Bhattacharjee, Cesar Parra-Cabrera, Yong Tae Kim, Alexandra P Kuo, Albert Folch
The advantageous physiochemical properties of poly(dimethylsiloxane) (PDMS) have made it an extremely useful material for prototyping in various technological, scientific, and clinical areas. However, PDMS molding is a manual procedure and requires tedious assembly steps, especially for 3D designs, thereby limiting its access and usability. On the other hand, automated digital manufacturing processes such as stereolithography (SL) enable true 3D design and fabrication. Here the formulation, characterization, and SL application of a 3D-printable PDMS resin (3DP-PDMS) based on commercially available PDMS-methacrylate macromers, a high-efficiency photoinitiator and a high-absorbance photosensitizer, is reported...
April 14, 2018: Advanced Materials
J P Russo, A Ipiña, J F Palazzolo, A B Cannavó, R D Piacentini, B Niklasson
BACKGROUND: Photoallergic contact dermatitis (PACD) to oxybenzone was reported for the first time in 1980. Oxybenzone is the most common photoallergen in the United States and Canada and the fourth most common .in Europe. There are no studies or data on the prevalence of oxybenzone PACD in Argentina. OBJECTIVE: To determine the proportion of photosensitive patients with PACD to oxybenzone. METHODS: We conducted a descriptive cross-sectional study of 35 patients with photosensitivity reactions confirmed by photopatch testing at the Research Center of Hospital Público San Martín in La Plata, Argentina, in 2015 and 2016...
April 11, 2018: Actas Dermo-sifiliográficas
Christopher J Stromberg, Edwin Jay Heilweil
[FeFe]-hydrogenases are efficient enzymes that produce hydrogen gas under mild conditions. Synthetic model compounds containing all CO or mixed CO/PMe3 ligands were previously studied by us and others with ultrafast ultraviolet (UV) or visible pump-infrared (IR) probe spectroscopy (TRIR) in an effort to better understand the function and interactions of the active site with light. Studies of anionic species containing cyano groups, which more closely match the biological active site, have been elusive. In this work, two model compounds dissolved in room temperature acetonitrile solution were examined: [Fe2(μ-S2C3H6)(CO)4(CN)2]2- (1) and [Fe2(μ-S2C2H4)(CO)4(CN)2]2- (2)...
April 13, 2018: Journal of Physical Chemistry. A
Julia Nomrowski, Oliver S Wenger
Photoinduced multielectron transfer and reversible accumulation of redox equivalents is accomplished in a fully integrated molecular heptad composed of four donors, two photosensitizers, and one acceptor. The second reduction of the dibenzo[1,2]dithiin acceptor occurs more easily than the first by 1.3 V, and this potential inversion facilitates the light-driven formation of a two-electron reduced state with a lifetime of 66 ns in deaerated CH3 CN. The quantum yield for formation of this doubly charge-separated photoproduct is 0...
April 13, 2018: Journal of the American Chemical Society
Yuhua Jia, Jinyu Li, Jincan Chen, Ping Hu, Longguang Jiang, Xueyuan Chen, Mingdong Huang, Zhuo Chen, Peng Xu
Clinical photosensitizers suffer from the disadvantages of fast photobleaching and high systemic toxicities due to the off-target photodynamic effects. To address these problems, we report a self-assembled pentalysine-phthalocyanine assembly nanodots (PPAN) fabricated by an amphipathic photosensitizer-peptide conjugate. We triggered the PDT effects of photosensitizers by precisely controlling the assembly and disintegration of the nanodots. In physiological aqueous conditions, PPAN exhibited a size-tunable spherical conformation with a highly positive shell of the polypeptides and a hydrophobic core of the π-stacking Pc moieties...
April 13, 2018: ACS Applied Materials & Interfaces
Xiao-Yang Zhu, Yanfang Geng, Hongjun Xiao, Linxiu Cheng, Hongyu Shi, Fengying Zhao, Kandong Hu, Xuan Guo, Bin Tu, Qingdao Zeng
Surface selective adsorption and separation are very important for the application of surface functional materials. In this study, a photosensitive diazo-macrocycle has been synthesized by solvent method with very low yield, which can adsorb onto the substrate surface modified with template molecule. By using this flexible template on the graphite surface, a simple separation strategy for macrocyclic molecule with specific shape and size from reaction mixtures was developed. Additionally, one of two azo units in this trapped photosensitive macrocycle could convert from trans to cis conformation under the UV irradiation due to the steric effect...
April 13, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Yu Li Huang, Yu Jie Zheng, Zhibo Song, Dongzhi Chi, Andrew T S Wee, Su Ying Quek
Since the first isolation of graphene, new classes of two-dimensional (2D) materials have offered fascinating platforms for fundamental science and technology explorations at the nanometer scale. In particular, 2D transition metal dichalcogenides (TMD) such as MoS2 and WSe2 have been intensely investigated due to their unique electronic and optical properties, including tunable optical bandgaps, direct-indirect bandgap crossover, strong spin-orbit coupling, etc., for next-generation flexible nanoelectronics and nanophotonics applications...
April 13, 2018: Chemical Society Reviews
Yusen Luo, Maria Wächtler, Kevin Barthelmes, Andreas Winter, Ulrich S Schubert, Benjamin Dietzek
Polyoxometalate (POM)-associated charge-separated states, formed by the photoinduced oxidation of a covalently attached photosensitizer and reduction of the POM, have attracted much attention due to the remarkable catalytic properties of the reduced POMs. However, short lifetimes of the POM-associated charge-separated state, which in some cases lead to the backward electron transfer being more rapid than the formation of the charge-separated state itself, are generally observed. Recently, we reported on the first example of a relative long-lived (τ = 470 ns) charge-separated state in a Ru(ii) bis(terpyridine)-POM molecular dyad...
April 13, 2018: Physical Chemistry Chemical Physics: PCCP
Toru Mizutani, Yasutoshi Murayama, Hisashi Ikoma, Tomohiro Arita, Toshiyuki Kosuga, Hirotaka Konishi, Ryo Morimura, Atsushi Shiozaki, Yoshiaki Kuriu, Masayoshi Nakanishi, Hitoshi Fujiwara, Kazuma Okamoto, Eigo Otsuji
Curative resection is necessary to survival in pancreatic cancer, however after surgery, pathologic examination sometimes diagnoses the remains of cancer at the resected stump. Therefore, it is necessary to evaluate the stump by intraoperative rapid pathological examination. 5-aminolevulinic acid(5-ALA)is an endogenous natural amino acid and precursor of the heme pathway. 5-ALA is metabolized and accumulated as protoporphyrin IX(Pp IX)that is photosensitive substance. 5-ALA mediated photodynamic diagnosis(PDD)(ALA-PDD)has high diagnostic ability...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Viktoria Klippenstein, Laetitia Mony, Pierre Paoletti
Approaches to remotely control and monitor ion channel operation with light are expanding rapidly in the biophysics and neuroscience fields. A recent development directly introduces light sensitivity into proteins by utilizing photosensitive unnatural amino acids (UAAs) incorporated using the genetic code expansion technique. The introduction of UAAs results in unique molecular level control and, when combined with the maximal spatiotemporal resolution and poor invasiveness of light, enables direct manipulation and interrogation of ion channel functionality...
April 10, 2018: Trends in Biochemical Sciences
Yun Ma, Shujun Zhang, Huanjie Wei, Yafang Dong, Liang Shen, Shujuan Liu, Qiang Zhao, Li Liu, Wai-Yeung Wong
In this study, a soft salt complex based photosensitizer has been developed for photodynamic therapy (PDT) of cancer cells. The iridium(iii) complex [Ir(L)(L')]3+(PF6-)3 (C1) with L and L' being terpyridine ligands (L = 4'-phenyl-2,2':6',2''-terpyridine, L' = 3-([2,2':6',2''-terpyridin]-4'-yl)-9-hexyl-9H-carbazole) was chosen as the cationic component, and the iridium(iii) complex [Ir(dfppy)2CN2]-Bu4N+ (A1) was selected as the anionic component. Complexes C1 and A1 are directly connected through electrostatic interaction to form a soft salt based photosensitizer (S1), which exhibited an enhanced singlet oxygen generation rate because of efficient energy transfer between two ionic metal complexes...
April 12, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Upendra Chitgupi, Jonathan F Lovell, Venugopal Rajendiran
Mesotetra(4-carboxyphenyl)porphyrin (mTCPP) is a commercially available small molecule fluorophore and photosensitizer with four free carboxylic acid groups. mTCPP can readily be conjugated with amines for facile attachment of functional groups. In this work, we synthesized and assessed tetravalent, lysine-conjugated mTCPP, for its potential applications in targeted imaging and photodynamic therapy. Fmoc-protected d-lysine or l-lysine was conjugated to mTCPP via amide coupling with the epsilon amine group of lysine, followed by Fmoc deprotection...
April 12, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Long Le-Quang, Rajaa Ghassan Farran, Youssef Lattach, Hugues Bonnet, Helene Jamet, Liliane Guerente, Emmanuel Maisonhaute, Jérôme Chauvin
We propose in this work a stepwise approach to construct photoelectrodes. This takes advantage of the self-assembly interactions between thiol with a gold surface and terpyridine ligands with first row transition metals. Here, a [Ru(bpy)3]2+ photosensitive center bearing a free terpyridine group has been used to construct two linear dyads on gold (Au/[ZnII-RuII]4+ and Au/[CoIII-RuII]5+). The stepwise construction was characterized by electrochemistry, quartz crystal microbalance and AFM imaging. The results show that the dyads behave as rigid layers and are inhomogeneously distributed on the surface...
April 12, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Mengmeng Chen, Lu Han, Jie Zhou, Chunyi Sun, Chengying Hu, Xinlong Wang, Zhongmin Su
Metal-organic frameworks (MOFs) as famous porous materials in CO2 adsorption, their performance in CO2 reduction attract researchers' great attention. A classical Co-MOF, Co-ZIF-9, has been proposed as a novel photocatalyst for reducing CO2 into chemical feedstocks. Herein, Co-ZIF-9 with rod-like structure was obtained through reflux. Ultra-small silver nanoparticles (Ag NPs, smaller than 5 nm) were doped into Co-ZIF-9 by photodeposition method. With the assistant of photosensitizer, the resultant composites Ag@Co-ZIF-9 show catalytic reactivity in converting CO2 into CO under visible-light irradiation...
April 12, 2018: Nanotechnology
Xianglong Tang, Feng Jing, Benlan Lin, Sheng Cui, Rutong Yu, Xiaodong Shen, Tingwei Wang
By overcoming drug resistance and subsequently enhancing the treatment, the combination therapy of photodynamic therapy (PDT) and chemotherapy has promising potential for cancer treatment. However, the major challenge is how to establish an advanced nanoplatform that can be efficiently guided to tumor sites and can then stably release both chemotherapy drugs and a photosensitizer simultaneously and precisely. In this study, which considered the possibility and targeting efficiency of a magnetic targeting strategy, a novel Fe3O4@mSiO2(DOX)@HSA(Ce6) nanoplatform was successfully built; this platform could be employed as an efficient synergistic antitumor nanoplatform with magnetic guidance for highly specific targeting and retention...
April 12, 2018: ACS Applied Materials & Interfaces
Ting-Lin Yen, Chao-Chien Chang, Chi-Li Chung, Wen-Chin Ko, Chih-Hao Yang, Cheng-Ying Hsieh
Traumatic brain injury (TBI) is one of the leading causes of mortality worldwide and leads to persistent cognitive, sensory, motor dysfunction, and emotional disorders. TBI-caused primary injury results in structural damage to brain tissues. Following the primary injury, secondary injuries which are accompanied by neuroinflammation, microglial activation, and additional cell death subsequently occur. Platonin, a cyanine photosensitizing dye, has been used to treat trauma, ulcers, and some types of acute inflammation...
April 6, 2018: International Journal of Molecular Sciences
Wenbo Hu, Meng Xie, Hui Zhao, Yufu Tang, Song Yao, Tingchao He, Chuanxiang Ye, Qi Wang, Xiaomei Lu, Wei Huang, Quli Fan
Elevated nitric oxide (NO) levels perform an important pathological role in various inflammatory diseases. Developing NO-activatable theranostic materials with a two-photon excitation (TPE) feature is highly promising for precision imaging and therapy, but constructing such materials is still a tremendous challenge. Here, we present the first example of a NO-activatable fluorescent photosensitizer ( DBB-NO ) accompanying extremely NO-elevated two-photon absorption (TPA) for efficient fluorescence imaging and photodynamic therapy (PDT)...
January 28, 2018: Chemical Science
Liangfeng Huang, Gaofei Wei, Xiaoqi Sun, Yali Jiang, Zeqian Huang, Yanjuan Huang, Yifeng Shen, Xiaoyu Xu, Yunhui Liao, Chunshun Zhao
Therapeutic effects of photodynamic therapy (PDT) are limited by the selectivity of photosensitizer (PS). Herein, a novel tumor-targeted drug-PS conjugate (Gan-ZnPc) which integrated with zinc phthalocyanine (ZnPc) and Ganetespib has been developed. ZnPc is a promising PS with remarkable photosensitization ability. Ganetespib is a heat shock protein 90 (Hsp90) inhibitor with preferential tumor selectivity and conjugated to ZnPc as a tumor-targeted ligand. The multifunctional small molecule conjugate, Gan-ZnPc, could be bound to extracellular Hsp90 and then selectively internalized into the tumor cells, followed by the generation of abundant intracellular reactive oxygen species (ROS) upon irradiation...
March 31, 2018: European Journal of Medicinal Chemistry
Clara Maria Gonçalves de Faria, Natalia Mayumi Inada, José Dirceu Vollet-Filho, Vanderlei Salvador Bagnato
Photodynamic therapy (PDT) is a technique with well-established principles that often demands repeated applications for sequential elimination of tumor cells. An important question concerns the way surviving cells from a treatment behave in the subsequent one. Threshold dose is a core concept in PDT dosimetry, as the minimum amount of energy to be delivered for cell destruction via PDT. Concepts of threshold distribution have shown to be an important tool for PDT results analysis in vitro. In this study, we used some of these concepts for demonstrating subsequent treatments with partial elimination of cells modify the distribution, which represents an increased resistance of the cells to the photodynamic action...
March 30, 2018: Journal of Photochemistry and Photobiology. B, Biology
Saroj Kumar Amar, Shruti Goyal, Ajeet K Srivastav, Deepti Chopra, Ratan Singh Ray
Benzophenone-2 (BP2), a common ingredient of sunscreens formulation is widely used as UV filter. We have assessed the photogenotoxic and photocytotoxic potential of BP2. Photostability test showed that BP2 is unstable under UV exposure. Cell proliferation assay revealed that viability of HaCaT cells significantly reduced under UVA, UVB and sunlight exposure. DCF fluorescence intensity proved intracellular ROS generation capacity of BP2 under sunlight, UVA and UVB irradiation. Photodynamic degradation of guanine base of DNA is promoted by BP2 under UV treatment...
April 4, 2018: Regulatory Toxicology and Pharmacology: RTP
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