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Ganoderma lucidum

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https://www.readbyqxmd.com/read/28802268/ornithine-decarboxylase-mediated-production-of-putrescine-influences-ganoderic-acid-biosynthesis-by-regulating-ros-in-ganoderma-lucidum
#1
Chen-Gao Wu, Jia-Long Tian, Rui Liu, Peng-Fei Cao, Tian-Jun Zhang, Ang Ren, Liang Shi, Ming-Wen Zhao
Putrescine is an important polyamine that participates in a variety of stress responses. Ornithine decarboxylase (ODC) is a key enzyme that catalyzes the biosynthesis of putrescine. A homolog of the gene encoding ODC was cloned from Ganoderma lucidum In the ODC-silenced strains, the transcript levels of the ODC gene and the putrescine content were significantly decreased. The ODC-silenced strains were more sensitive to oxidative stress. The content of ganoderic acid was increased by approximately 43-46% in the ODC-silenced strains...
August 11, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28798349/evaluation-on-quality-consistency-of-ganoderma-lucidum-dietary-supplements-collected-in-the-united-states
#2
Ding-Tao Wu, Yong Deng, Ling-Xiao Chen, Jing Zhao, Anton Bzhelyansky, Shao-Ping Li
Ganoderma lucidum is a well-known medicinal mushroom. At present, numerous G. lucidum products have emerged in the form of dietary supplements in the United States due to its various benefits. However, the quality consistency of these products based on their label ingredients has seldom been evaluated due to the lack of a suitable toolkit. In this study, 19 batches of products of G. lucidum (Red Reishi, Reishi), herbal/mushroom supplements purchased in the United States, were evaluated based on their bioactive components including triterpenes and polysaccharides by using chromatographic methods and saccharide mapping...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28761429/neuroprotective-effects-of-ganoderma-lucidum-polysaccharides-against-oxidative-stress-induced-neuronal-apoptosis
#3
Xin-Zhi Sun, Ying Liao, Wei Li, Li-Mei Guo
Ganoderma lucidum polysaccharides have protective effects against apoptosis in neurons exposed to ischemia/reperfusion injury, but the mechanisms are unclear. The goal of this study was to investigate the underlying mechanisms of the effects of ganoderma lucidum polysaccharides against oxidative stress-induced neuronal apoptosis. Hydrogen peroxide (H2O2) was used to induce apoptosis in cultured cerebellar granule cells. In these cells, ganoderma lucidum polysaccharides remarkably suppressed H2O2-induced apoptosis, decreased expression of caspase-3, Bax and Bim and increased that of Bcl-2...
June 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28760544/the-potential-of-ganoderma-lucidum-extracts-as-bioactive-ingredients-in-topical-formulations-beyond-its-nutritional-benefits
#4
Oludemi Taofiq, Sandrina A Heleno, Ricardo C Calhelha, Maria José Alves, Lillian Barros, Ana M González-Paramás, Maria F Barreiro, Isabel C F R Ferreira
Ganoderma lucidum was characterized in terms of nutritional value and chemical composition. Thereafter, ethanolic Soxhlet extracts were evaluated for antioxidant, anti-inflammatory, antityrosinase, antimicrobial and cytotoxic effects, and further characterized in terms of phenolic acids, polysaccharides and triterpenoids. Finally, the obtained extracts were tested as cosmeceutical ingredients. G. lucidum proved to be a source of macronutrients and important bioactive compounds such as terpenoids, specially triterpenoids, and polysaccharides...
July 29, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28720793/genome-wide-identification-and-characterization-of-natural-antisense-transcripts-by-strand-specific-rna-sequencing-in-ganoderma-lucidum
#5
Junjie Shao, Haimei Chen, Dan Yang, Mei Jiang, Hui Zhang, Bin Wu, Jianqin Li, Lichai Yuan, Chang Liu
Ganoderma lucidum is a white-rot fungus best-known for its medicinal and ligninolytic activities. To discover the underlying genes responsible for these activities, we identified and characterized the natural antisense transcripts (NATs) using strand-specific (ss) RNA-seq data obtained from the mycelia, primordia and fruiting bodies. NATs were identified using a custom pipeline and then subjected to functional enrichment and differential expression analyses. A total of 1613 cis- and 244 trans- sense and antisense transcripts were identified...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28702429/wild-mushrooms-a-potential-source-of-nutritional-and-antioxidant-attributes-with-acceptable-toxicity
#6
Sumaira Sharif, Muhammad Shahid, Muhammad Mushtaq, Sumia Akram, Ayoub Rashid
This paper describes in detail proximate composition, nutritional profile, phytochemical constituents, antioxidant activities, antimicrobial potential, and antihemolytic activity (towards human erythrocytes) of various fractions of wild Ganoderma lucidum. Proximate analysis established that wild G. lucidum comprises about 87.02±5.45% of moisture, and the remaining part is a rich source of proteins (8.59±0.37%), crude fiber (54.21±1.2%), and carbohydrate (35.16%) with smaller fat content (3.33 %). Similarly, phytochemical screening revealed the presence of flavonoids (217...
June 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/28695905/corrigendum-ganoderma-lucidum-reduces-obesity-in-mice-by-modulating-the-composition-of-the-gut-microbiota
#7
Chih-Jung Chang, Chuan-Sheng Lin, Chia-Chen Lu, Jan Martel, Yun-Fei Ko, David M Ojcius, Shun-Fu Tseng, Tsung-Ru Wu, Yi-Yuan Margaret Chen, John D Young, Hsin-Chih Lai
This corrects the article DOI: 10.1038/ncomms8489.
July 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/28695802/effect-of-ganoderma-lucidum-preparation-on-the-behavior-biochemistry-and-autoimmune-parameters-of-mouse-models-of-app-ps1-double-transgenic-alzheimer-s-disease
#8
Chuan Qin, Shanqiu Wu, Baosheng Chen, Xiaoxian Wu, Kunyao Qu, Junmin Liu, Guifang Zhang, Yanfeng Xu, Shunli Shu, Lihua Sun, Yanhong Li, Hua Zhu, Lan Huang, Chunmei Ma, Yuhuan Xu, Yunlin Han, Yaozeng Lu
Objective To evaluate the efficacy of Ganoderma lucidum preparation on the behaviors,biochemistry,and autoimmunity parameters of mouse models of APP/PS-1 double transgenic Alzheimer's disease(AD).Methods A total of 44 4-month-old APP/PS-1 double transgenic AD mice were randomly divided into AD model group,Aricept group,Ganoderma lucidum middle-dose(LZ-M)group,and Ganoderma lucidum high-dose(LZ-H)group,with 11 mice in each group.In addition,10 4-month-old C57BL/6 mice were used as the control group.Water maze test was conducted to observe the behavior changes,and the protein expressions in brain tissues were detected by Western blot analysis...
June 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28681206/protective-effect-of-ganoderma-lucidum-polysaccharide-against-carbon-tetrachloride-induced-hepatic-damage-in-precision-cut-carp-liver-slices
#9
Yingjuan Liu, Chunyun Zhang, Jinliang Du, Rui Jia, Liping Cao, Galina Jeney, Hiroki Teraoka, Pao Xu, Guojun Yin
The aim of the present study was to investigate the protective effects of Ganoderma lucidum polysaccharide (GLPS) against carbon tetrachloride (CCl4)-induced hepatotoxicity in vitro in common carp. Precision-cut liver slices (PCLSs), which closely resemble the organ from which they are derived, were employed as an in vitro model system. GLPS (0.1, 0.3, and 0.6 mg/ml) was added to PCLS culture system before the exposure to 12 mM CCl4. The supernatants and slices were collected to detect molecular and biochemical responses to CCl4 and PCLS treatments...
July 5, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28653896/ganoderma-lucidum-targeting-lung-cancer-signaling-a-review
#10
REVIEW
Balraj Singh Gill, Navgeet, Sanjeev Kumar
Lung cancer causes huge mortality to population, and pharmaceutical companies require new drugs as an alternative either synthetic or natural targeting lung cancer. The conventional therapies cause side effects, and therefore, natural products are used as a therapeutic candidate in lung cancer. Chemical diversity among natural products highlights the impact of evolution and survival of fittest. One such neglected natural product is Ganoderma lucidum used for promoting health and longevity for a longer time...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28618378/simultaneously-upgrading-biogas-and-purifying-biogas-slurry-using-cocultivation-of-chlorella-vulgaris-and-three-different-fungi-under-various-mixed-light-wavelength-and-photoperiods
#11
Weixing Cao, Xue Wang, Shiqing Sun, Changwei Hu, Yongjun Zhao
In order to purify biogas slurry and biogas simultaneously, three different fungi, Pleurotus geesteranus (P. geesteranus), Ganoderma lucidum (G. lucidum), and Pleurotus ostreatus (P. ostreatus) were pelletized with Chlorella vulgaris (C. vulgaris). The results showed that the optimal light wavelength ratio for red:blue was 5:5 for these three different fungi-assisted C. vulgaris, resulting in higher specific growth rate as well as nutrient and CO2 removal efficiency compared with other ratios. G. lucidum/C...
October 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28603120/enzyme-inhibitory-antifungal-antibacterial-and-hemolytic-potential-of-various-fractions-of-colebrookia-oppositifolia
#12
Tauheeda Riaz, Muhammad Athar Abbasi, Azizur Rehman, Sabahat Zahra Siddiqui, Muhammad Shahid, Hina Fatima, Muhammad Ashraf, Syeda Abida Ejaz, Zahid Ghulam Rasool, Ghulam Hasan Abbasi
The purpose of the present investigation was to assess the enzyme inhibition, antifungal, antibacterial and hemolytic activities of various fractions of Colebrookia oppositifolia Smith. The MeOH extract of plant was dissolved in dist. water and partitioned with n-hexane, CHCl3, EtOAc and n-BuOH sequentially. Enzyme inhibition studies were done against four enzymes i.e. α-glucosidase, butyrylcholinesterase, acetyl cholinesterase and lipoxygenase. Ethyl acetate fraction possessed very good activity against α-glucosidase (IC50 57...
January 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28572880/effect-of-medicinal-mushrooms-on-blood-cells-under-conditions-of-diabetes-mellitus
#13
REVIEW
Taras Vitak, Borys Yurkiv, Solomon Wasser, Eviatar Nevo, Natalia Sybirna
Diabetes mellitus (DM) is the third most common non-infectious disease leading to early disability and high mortality. Moreover, the number of patients is growing every year. The main symptom of DM is hyperglycemia. Increased levels of blood glucose activate polyol, hexosamine, and protein kinase metabolic pathways cause the intensification of non-enzymatic glycosylation and nitration of macromolecules. This, in turn, leads to the development of oxidative and nitrative stresses and secondary complications, such as different kinds of micro- and macroangiopathies...
May 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28543056/cloning-and-analysis-of-the-glwc-1-and-glwc-2-genes-encoding-putative-blue-light-photoreceptor-from-ganoderma-lucidum
#14
Xinran Xu, Xiangdong Chen, Wumengxiao Yu, Yu Liu, Weiwei Zhang, Jin Lan
Blue light plays an important role during the growth of Ganoderma lucidum, one of the best-known medicinal macrofungi in China. In the present study, we cloned Glwc-1 and Glwc-2, the homologue of the blue light photoreceptors Ncwc-1 and Ncwc-2 of Neurospora crassa, from G. lucidum. The deduced amino acid sequence of Glwc-1 contained the similar function domains as NcWC-1 including LOV, PAS B, PAS C, and PAC domains. The deduced amino acid sequence of Glwc-2 contained PAS domain and GATA-type zinc finger (Znf) domain as well as NcWC-2...
May 23, 2017: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/28527898/triterpenes-and-meroterpenes-from-ganoderma-lucidum-with-inhibitory-activity-against-hmgs-reductase-aldose-reductase-and-%C3%AE-glucosidase
#15
Baosong Chen, Jin Tian, Jinjin Zhang, Kai Wang, Li Liu, Bo Yang, Li Bao, Hongwei Liu
Seven new compounds including four lanostane triterpenoids, lucidenic acids Q-S (1-3) and methyl ganoderate P (4), and three triterpene-farnesyl hydroquinone conjugates, ganolucinins A-C (5-7), one new natural product ganomycin J (8), and 73 known compounds (9-81) were isolated from fruiting bodies of Ganoderma lucidum. The structures of the compounds 1-8 were determined by spectroscopic methods. Bioactivities of compounds isolated were assayed against HMG-CoA reductase, aldose reductase, α-glucosidase, and PTP1B...
July 2017: Fitoterapia
https://www.readbyqxmd.com/read/28510717/fast-population-growth-in-physogastry-reproduction-of-luciaphorus-perniciosus-acari-pygmephoridae-at-different-temperatures
#16
Prapassorn Bussaman, Chirayu Sa-Uth, Angsumarn Chandrapatya, Remzi Atlihan, Ayhan Gökçe, Pavel Saska, Hsin Chi
Luciaphorus perniciosus Rack is one of the most serious pests of several cultivated mushroom species including Ganoderma lucidum (Fr.), Flammulina velutipes Karst., Auricularia polytricha (Mont.) Saac., Lentinus polychrous Lev., and Lentinus squarrosulus (Mont.) Singer in Thailand. Adult female Lu. perniciosus produce offspring inside their physogastric hysterosomas, with all embryos developing through to the adult stage while remaining in the abdomen. Once the abdomen ruptures, the female parent dies and the offspring consisting of mostly fertilized female adults along with a few male adults continue to emerge from the cadaver of the mother for a period of several days...
May 16, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28496309/effect-of-electromagnetic-fields-and-antioxidants-on-the-trace-element-content-of-rat-teeth
#17
Mehmet Sinan Dogan, Mehmet Cihan Yavas, Yasemin Yavuz, Sait Erdogan, İsmail Yener, İbrahim Simsek, Zeki Akkus, Veysel Eratilla, Abdulsamet Tanik, Mehmet Zulkuf Akdag
The purpose of this study was to examine the possible effect of extremely low-frequency electromagnetic fields (ELF-EMFs), from a high-voltage source, on rat teeth in terms of changes in trace elements (TEs) and the effect of antioxidants (melatonin [MLT] and Ganoderma lucidum [GL]) in counteracting these effects. We used adult male Wistar albino rats with a mean weight of 250-300 g and divided the rats into eight groups. The groups were subjected to an ELF-EMF that was applied with a high-voltage line for 8 hours/day for 26 days (Groups I, II, and III) or 52 days (Groups V, VI, and VII)...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28484937/effects-of-ganoderma-lucidum-shell-broken-spore-on-oxidative-stress-of-the-rabbit-urinary-bladder-using-an-in-vivo-model-of-ischemia-reperfusion
#18
Robert M Levin, Li Xia, Wu Wei, Catherine Schuler, Robert E Leggett, Alpha D-Y Lin
Oxidative stress plays an important role in specific disease pathophysiology and the aging process. In the history of human kind, many herbs were utilized for disease prevention and anti-aging treatment. However, there are few direct evidences provided by modern laboratory technology. The current study was designed to evaluate Ganoderma Lucidum's (GL) ability to reduce the damage from in vivo ischemia/reperfusion (I/R) using a rabbit model of I/R that has been effectively utilized to prove the effects of drugs and supplements to reduce oxidative stress...
May 8, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28473815/gel-based-purification-and-biochemical-study-of-laccase-isozymes-from-ganoderma-sp-and-its-role-in-enhanced-cotton-callogenesis
#19
Amit Kumar, Deepti Singh, Krishna K Sharma, Sakshi Arora, Amarjeet K Singh, Sarvajeet S Gill, Barkha Singhal
Basidiomycetous fungi, Ganoderma lucidum MDU-7 and Ganoderma sp. kk-02 secreted multiple laccase isozymes under diverse growth condition. Aromatic compounds and metal salts were also found to regulate the differential expression of laccase isozymes from both the Ganoderma sp. Laccase isozymes induced in the presence of copper from G. lucidum MDU-7 were purified by gel-based (native-PAGE) purification method. The purity of laccase isozymes was checked by zymogram and SDS-PAGE. The SDS-PAGE of purified proteins confirmed the multimeric nature of laccase isozymes...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28438681/immobilized-lignin-peroxidase-from-ganoderma-lucidum-ibl-05-with-improved-dye-decolorization-and-cytotoxicity-reduction-properties
#20
Raheela Shaheen, Muhammad Asgher, Fatima Hussain, Haq Nawaz Bhatti
Use of free microbial enzymes for bioremediation and other industrial applications has several disadvantages like low stability and non-reusability in repeated batch operations. Immobilized enzymes are stable, recoverable and reusable in industrial processes. In this scenario G. lucidum IBL-05 LiP was entrapped in Ca-alginate beads using optimum concentrations of Na-alginate (4%), calcium chloride (0.2M) and glutraldehyde (0.02%). Optimum pH (pH 5) and temperature (55°C) for entrapped LiP were improved as compared to free LiP...
October 2017: International Journal of Biological Macromolecules
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