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Ganoderma lucidum

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https://www.readbyqxmd.com/read/28105862/structural-data-and-immunomodulatory-properties-of-a-water-soluble-heteroglycan-extracted-from-the-mycelium-of-an-italian-isolate-of-ganoderma-lucidum
#1
Raffaele Carrieri, Rosanna Manco, Daniela Sapio, Marco Iannaccone, Andrea Fulgione, Marina Papaianni, Bruna de Falco, Laura Grauso, Paola Tarantino, Flora Ianniello, Virginia Lanzotti, Ernesto Lahoz, Rosanna Capparelli
Mushrooms produce a wide range of bioactive polysaccharides, different from each other in chemical structure and biological effects. In the last years, the idea to develop functional foods or drugs containing fungal polysaccharides is attracting great attention. Fruiting bodies of Basidiomycetes Ganoderma lucidum are commonly used in Oriental medicine to treat several disorders. G. lucidum polysaccharides - mainly β-glucans and heteroglycans - have numerous biological properties such as antitumour and immunomodulatory activities...
January 20, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28099150/elimination-of-quiescent-slow-cycling-cells-via-reducing-quiescence-depth-by-natural-compounds-purified-from-ganoderma-lucidum
#2
Jian Dai, Matthew A Miller, Nicholas J Everetts, Xia Wang, Peng Li, Ye Li, Jian-Hua Xu, Guang Yao
The medical mushroom Ganoderma lucidum has long been used in traditional Chinese medicine and shown effective in the treatment of many diseases including cancer. Here we studied the cytotoxic effects of two natural compounds purified from Ganoderma lucidum, ergosterol peroxide and ganodermanondiol. We found that these two compounds exhibited cytotoxicity not only against fast proliferating cells, but on quiescent, slow-cycling cells. Using a fibroblast cell-quiescence model, we found that the cytotoxicity on quiescent cells was due to induced apoptosis, and was associated with a shallower quiescent state in compound-treated cells, resultant from the increased basal activity of an Rb-E2F bistable switch that controls quiescence exit...
January 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28092004/bio-based-degradation-of-emerging-endocrine-disrupting-and-dye-based-pollutants-using-cross-linked-enzyme-aggregates
#3
Muhammad Bilal, Muhammad Asgher, Hafiz M N Iqbal, Hongbo Hu, Xuehong Zhang
In this study, manganese peroxidase (MnP) from an indigenous white-rot fungus Ganoderma lucidum IBL-05 was insolubilized in the form of cross-linked enzyme aggregates (CLEAs) using various aggregating agents, i.e., acetone, ammonium sulfate, ethanol, 2-propanol, and tert-butanol, followed by glutaraldehyde (GA) cross-linking. The precipitant type, MnP, and GA concentrations affected the CLEAs activity recovery and aggregation yield. Among precipitants used, acetone appeared to be the most efficient aggregation agent, providing the highest activity recovery and aggregation yield of 31...
January 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28076758/polysaccharides-from-ganoderma-lucidum-promote-cognitive-function-and%C3%A2-neural-progenitor-proliferation-in-mouse-model-of-alzheimer-s-disease
#4
Shichao Huang, Jianxin Mao, Kan Ding, Yue Zhou, Xianglu Zeng, Wenjuan Yang, Peipei Wang, Cun Zhao, Jian Yao, Peng Xia, Gang Pei
Promoting neurogenesis is a promising strategy for the treatment of cognition impairment associated with Alzheimer's disease (AD). Ganoderma lucidum is a revered medicinal mushroom for health-promoting benefits in the Orient. Here, we found that oral administration of the polysaccharides and water extract from G. lucidum promoted neural progenitor cell (NPC) proliferation to enhance neurogenesis and alleviated cognitive deficits in transgenic AD mice. G. lucidum polysaccharides (GLP) also promoted self-renewal of NPC in cell culture...
January 10, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28056060/intraspecific-variation-and-phylogenetic-relationships-are-revealed-by-its1-secondary-structure-analysis-and-single-nucleotide-polymorphism-in-ganoderma-lucidum
#5
Xiuqing Zhang, Zhangyang Xu, Haisheng Pei, Zhou Chen, Xiaoyan Tan, Jing Hu, Bin Yang, Junshe Sun
Ganoderma lucidum is a typical polypore fungus used for traditional Chinese medical purposes. The taxonomic delimitation of Ganoderma lucidum is still debated. In this study, we sequenced seven internal transcribed spacer (ITS) sequences of Ganoderma lucidum strains and annotated the ITS1 and ITS2 regions. Phylogenetic analysis of ITS1 differentiated the strains into three geographic groups. Groups 1-3 were originated from Europe, tropical Asia, and eastern Asia, respectively. While ITS2 could only differentiate the strains into two groups in which Group 2 originated from tropical Asia gathered with Groups 1 and 3 originated from Europe and eastern Asia...
2017: PloS One
https://www.readbyqxmd.com/read/28052025/cytotoxic-lanostane-type-triterpenoids-from-the-fruiting-bodies-of-ganoderma-lucidum-and-their-structure-activity-relationships
#6
Shaodan Chen, Xiangmin Li, Tianqiao Yong, Zhanggen Wang, Jiyan Su, Chunwei Jiao, Yizhen Xie, Burton B Yang
We conducted a study of Ganoderma lucidum metabolites and isolated 35 lanostane-type triterpenoids, including 5 new ganoderols (1-5). By spectroscopy, we compared the structures of these compounds with known related compounds in this group. All of the isolated compounds were assayed for their effect against the human breast carcinoma cell line MDA-MB-231 and hepatocellular carcinoma cell line HepG2. Corresponding three-dimensional quantitative structure-activity relationship (3D-QSAR) models were built and analyzed using Discovery Studio...
December 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/28010928/ganoderma-lucidum-total-triterpenes-induce-apoptosis-in-mcf-7-cells-and-attenuate-dmba-induced-mammary-and-skin-carcinomas-in-experimental-animals
#7
T P Smina, B Nitha, T P A Devasagayam, K K Janardhanan
Ganoderma lucidum total triterpenes were evaluated for its apoptosis-inducing and anti-cancer activities. Cytotoxicity and pro-apoptotic effect of total triterpenes were evaluated in human breast adenocarcinoma (MCF-7) cell line using MTT assay and DNA fragmentation analysis. Total triterpenes induced apoptosis in MCF-7 cells by down-regulating the levels of cyclin D1, Bcl-2, Bcl-xL and also by up-regulating the levels of Bax and caspase-9. Anti-carcinogenicity of total triterpenes was analysed using dimethyl benz [a] anthracene (DMBA) induced skin papilloma and mammary adenocarcinoma in Swiss albino mice and Wistar rats respectively...
January 2017: Mutation Research
https://www.readbyqxmd.com/read/28008811/evaluation-of-antianxiety-potential-of-four-ganoderma-agaricomycetes-species-from-india-in-mice
#8
Ranjeet Singh, Gurpaul Singh Dhingra, Richa Shri
The genus Ganoderma consists of widespread polypore mushrooms that have traditionally been used to reduce stress and anxiety. However, scientific evidence for this is not adequate. Hence, this study was designed to investigate the anxiolytic potential of G. applanatum, G. brownii, G. lucidum, and G. philippii collected from Uttarakhand, India. Various extracts of dried, powdered basidiocarps were prepared using different solvents-namely, petroleum ether, chloroform, methanol, and distilled water-by successive Soxhlet extraction...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/28008808/antitumor-activity-of-extracts-from-medicinal-basidiomycetes-mushrooms
#9
Elena Vetchinkina, Alexandr Shirokov, Alla Bucharskaya, Nikita Navolokin, Artur Prilepskii, Andrey Burov, Galina Maslyakova, Valentina E Nikitina
Aqueous extracts from the vegetative submerged mycelia of cultivated Basidiomycetes Ganoderma lucidum, Lentinus edodes, and Grifola frondosa, as well as from the fruiting bodies of G. lucidum, were found to have antitumor activity. The antitumor effect of the mycelial extracts from all 3 fungal species was ascertained in vivo in rats with implanted kidney cancer. Dystrophic changes in tumor cells and tumor necrosis (up to 90%) were noted. In vitro cytotoxicity studies of the A549 human lung adenocarcinoma cell line and HEp-2 human laryngeal epidermoid carcinoma cells showed that the extracts from the G...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27997578/identification-and-characterisation-of-a-novel-protein-fip-sch3-from-stachybotrys-chartarum
#10
Shuying Li, Leiming Zhao, Wenyi Xu, Zhonghao Jiang, Jun Kang, Fengzhong Wang, Fengjiao Xin
In this study, a novel FIP named FIP-sch3 has been identified and characterised. FIP-sch3 was identified in the ascomycete Stachybotrys chartarum, making it the second FIP to be identified outside the order of Basidiomycota. Recombinant FIP-sch3 (rFIP-shc3) was produced in Escherichia coli and purified using GST-affinity magnetic beads. The bioactive characteristics of FIP-sch3 were compared to those of well-known FIPs LZ-8 from Ganoderma lucidum and FIP-fve from Flammulina velutipes, which were produced and purified using the same method...
2016: PloS One
https://www.readbyqxmd.com/read/27959406/ganoderma-lucidum-polysaccharides-protect-fibroblasts-against-uvb-induced-photoaging
#11
Qinghai Zeng, Fang Zhou, Li Lei, Jing Chen, Jianyun Lu, Jianda Zhou, Ke Cao, Lihua Gao, Fang Xia, Shu Ding, Lihua Huang, Hong Xiang, Jingjing Wang, Yangfan Xiao, Rong Xiao, Jinhua Huang
Ganoderma lucidum has featured in traditional Chinese medicine for >1,000 years. Ganoderma polysaccharides (GL-PS), a major active ingredient in Ganoderma, confer immune regulation, antitumor effects and significant antioxidant effects. The aim of the present study was to investigate the efficacy and mechanism of GL‑PS‑associated inhibition of ultraviolet B (UVB)‑induced photoaging in human fibroblasts in vitro. Primary human skin fibroblasts were cultured, and a fibroblast photoaging model was built through exposure to UVB...
January 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27912745/ganoderma-lucidum-beta-1-3-1-6-glucan-as-an-immunomodulator-in-inflammation-induced-by-a-high-cholesterol-diet
#12
Yu-Sheng Wu, Shu-Ying Ho, Fan-Hua Nan, Shiu-Nan Chen
BACKGROUND: Binding of beta 1,3/1,6 glucan of Ganoderma lucidum (G. lucidum) with the receptor results in a series of signal transfers (signalling cascades), which activates the transcription factors for regulating inflammation. Excess cholesterol intake leads to an increase in the distance between fat cells and capillaries, which may cause hypoxia in the fat tissue of obese mice. This hypoxia induces the death of fat cells, resulting in the inflammation of adipose tissue or an increase in the inflammatory gene expression associated with obesity...
December 3, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27910775/hepatoprotective-effects-and-mechanisms-of-action-of-triterpenoids-from-lingzhi-or-reishi-medicinal-mushroom-ganoderma-lucidum-agaricomycetes-on-%C3%AE-amanitin-induced-liver-injury-in-mice
#13
Huihui Wu, Shanshan Tang, Zhaoqin Huang, Qian Zhou, Ping Zhang, Zuohong Chen
Most fatal mushroom poisonings are caused by species of the genus Amanita; the amatoxins are responsible for acute liver failure and death in humans. Ganoderma lucidum is a well-known traditional medicinal mushroom that has been shown to have obvious hepatoprotective effects. This study evaluated the hepatoprotective effects of triterpenoids from G. lucidum on liver injury induced by a-amanitin (α-AMA) in mice and the mechanisms of action of these triterpenoids, including radical scavenging and antiapoptosis activities...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27910768/pharmacological-properties-of-biocompounds-from-spores-of-the-lingzhi-or-reishi-medicinal-mushroom-ganoderma-lucidum-agaricomycetes-a-review
#14
Carlos Ricardo Soccol, Lucas Yamasaki Bissoqui, Cristine Rodrigues, Rosalia Rubel, Sandra R B R Sella, Fan Leifa, Luciana Porto de Souza Vandenberghe, Vanete Thomaz Soccol
Ganoderma lucidum is a well-known representative of mushrooms that have been used in traditional Chinese medicine for centuries. New discoveries related to this medicinal mushroom and its biological properties are frequently reported. However, only recently have scientists started to pay special attention to G. lucidum spores. This is in part because of the recent development of methods for breaking the spore wall and extracting biocompounds from the spore. Although some research groups are working with G. lucidum spores, data in the literature are still limited, and the methods used have not been systematized...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27910761/investigation-of-requisites-for-the-optimal-mycelial-growth-of-the-lingzhi-or-reishi-medicinal-mushroom-ganoderma-lucidum-agaricomycetes-on-oil-palm-biomass-in-malaysia
#15
Surya Sudheer, Asgar Ali, Sivakumar Manickam
Rigorous research has been carried out regarding the cultivation of Ganoderma lucidum using different agricultural residues. Nevertheless, large-scale cultivation and the separation of active compounds of G. lucidum are still challenges for local farmers. The objective of this study was to evaluate the use of oil palm waste fibers such as empty fruit bunch fibers and mesocarp fibers as effective substrates for the growth of G. lucidum mycelia to study the possibility of solid-state cultivation and to determine the optimum conditions necessary for the growth of mycelia of this mushroom on these waste fibers...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27902927/antidiabetic-activity-of-ganoderma-lucidum-polysaccharides-f31-down-regulated-hepatic-glucose-regulatory-enzymes-in-diabetic-mice
#16
Chun Xiao, Qingping Wu, Jumei Zhang, Yizhen Xie, Wen Cai, Jianbin Tan
ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (Lin Zhi) has been used to treat diabetes in Chinese folk for centuries. Our laboratory previously demonstrated that Ganoderma lucidum polysaccharides (GLPs) had hypoglycemic effects in diabetic mice. Our aim was to identify the main bioactives in GLPs and corresponding mechanism of action. MATERIALS AND METHODS: Four polysaccharide-enriched fraction were isolated from GLPs and the antidiabetic activities were evaluated by type 2 diabetic mice...
January 20, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27900038/antitumor-effects-and-mechanisms-of-ganoderma-extracts-and-spores-oil
#17
Chun Chen, Peng Li, Ye Li, Guan Yao, Jian-Hua Xu
Ganoderma lucidum is a popular herbal medicine used in China to promote health. Modern studies have disclosed that the active ingredients of Ganoderma can exhibit several effects, including antitumor effects and immunomodulation. The present study evaluated the antitumor effects of self-prepared Ganoderma extracts and spores oil, and investigated the possible underlying mechanisms by observing the effects of the extracts and oil on topoisomerases and the cell cycle. The results showed that Ganoderma extracts and spores oil presented dose-dependent inhibitory effects on tumor cells...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27885803/rapid-and-sensitive-determination-of-phytosterols-in-functional-foods-and-medicinal-herbs-by-using-uhplc-ms-ms-with-microwave-assisted-derivatization-combined-with-dual-ultrasound-assisted-dispersive-liquid-liquid-microextraction
#18
Jing Sun, Xian-En Zhao, Jun Dang, Xiaoyan Sun, Longfang Zheng, Jinmao You, Xiao Wang
In this work, a hyphenated technique of dual ultrasound-assisted dispersive liquid-liquid microextraction combined with microwave-assisted derivatization followed by ultra high performance liquid chromatography tandem mass spectrometry has been developed for the determination of phytosterols in functional foods and medicinal herbs. Multiple reaction monitoring mode was used for the tandem mass spectrometry detection. A mass spectrometry sensitive reagent, 4'-carboxy-substituted rosamine, has been used as the derivatization reagent for five phytosterols, and internal standard diosgenin was used for the first time...
November 25, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27878254/restoration-of-the-tumor-suppressor-function-to-mutant-p53-by-ganoderma-lucidum-polysaccharides-in-colorectal-cancer-cells
#19
Dan Jiang, Lingyao Wang, Tong Zhao, Zhaoyu Zhang, Renxia Zhang, Jingji Jin, Yong Cai, Fei Wang
Ganoderma lucidum polysaccharides (GLPs), isolated from spores, mycelia and fruiting bodies of Ganoderma lucidum, have been suggested to possess anticancer activities in a large number of basic studies. A recent survey revealed that GLP-induced inhibition of cancer cell growth was dependent on the existence of functional p53. However, the actual role of p53-mediated tumor-suppressing pathways in facilitating the anticancer effect of GLPs is still unclear. In the present study, we investigated the interaction between GLPs and mutant p53 that exists in more than half of the known types of cancers...
January 2017: Oncology Reports
https://www.readbyqxmd.com/read/27842810/evaluation-of-microwave-assisted-and-pressurized-liquid-extractions-to-obtain-%C3%AE-d-glucans-from-mushrooms
#20
Fhernanda Ribeiro Smiderle, Diego Morales, Alicia Gil-Ramírez, Liana Inara de Jesus, Bienvenida Gilbert-López, Marcello Iacomini, Cristina Soler-Rivas
Microwave-assisted extraction (MAE) and pressurized liquid extraction (PLE) were compared as advanced technologies to obtain polysaccharides (particularly biologically active β-glucans) from Pleurotus ostreatus and Ganoderma lucidum fruiting bodies. Extraction effectiveness was compared by a full-factorial experimental design (response surface methodology, RSM), using water as extraction solvent. Total carbohydrate content of the obtained extracts and polysaccharide yields were the variable responses investigated, while temperature and extraction time were the experimental factors...
January 20, 2017: Carbohydrate Polymers
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