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Ganoderma lucidum

Surya Sudheer, Zain Taha, Sivakumar Manickam, Asgar Ali, Poh Guat Cheng
Following the importance of antler-type fruiting bodies of Ganoderma lucidum, in this study, the impact of main growth parameters such as ventilation and light on the development of antler-type fruiting bodies has been investigated together with the determination of physico-chemical properties of antler fruiting bodies. For this, the primordia bags of G. lucidum were kept under controlled ventilation to adjust the CO2 produced by the mushrooms owing to its respiration under light and dark conditions. The bioactive compounds such as phenolics, flavonoids, water-soluble polysaccharides and ganoderic acid showed a two-fold increase in the antler-type fruiting bodies as compared to normal kidney-shaped fruiting bodies...
May 2018: Fungal Biology
Huiwen Ren, Xiangbo Meng, Jian Yin, Jingyan Sun, Qingfeng Huang, Zhuming Yin
BACKGROUND: Thioredoxin-1 (Trx-1) plays an important role in defensing the skin flap ischemia-reperfusion injury. Ganoderma lucidum polysaccharide peptide (GLPP) is the major component of Ganoderma lucidum, which possesses potent antioxidant and antiapoptotic activity. Our study aims to determine whether GLPP could attenuate the skin flap ischemia-reperfusion injury and investigate possible mechanisms involved. METHODS: The dermoprotective effect and mechanisms were assessed by an in vivo mouse ischemia-reperfusion flap model and an in vitro epithelial skin cell hypoxia/reoxygenation model...
March 29, 2018: Plastic and Reconstructive Surgery
Yang Qin, Liu Xiong, Man Li, Jing Liu, Hao Wu, Hongwei Qiu, Hongyan Mu, Xingfeng Xu, Qingjie Sun
Due to their biocompatibility and biodegradability in vivo, natural polysaccharides are effective nanocarriers for delivery of active ingredients or drugs. Moreover, bioactive polysaccharides, such as tea, Ganoderma lucidum, and Momordica charantia polysaccharides (TP, GLP, and MCP), have antibacterial, antioxidant, antitumor, and antiviral properties. In this study, tea, Ganoderma lucidum, and Momordica charantia polysaccharide nanoparticles (TP-NPs, GLP-NPs, and MCP-NPs) were prepared via the nanoprecipitation approach...
April 12, 2018: Journal of Agricultural and Food Chemistry
Jasmina Lj Ćilerdžić, Ivana V Sofrenić, Vele V Tešević, Ilija D Brčeski, Sonja N Duletić-Laušević, Jelena B Vukojević, Mirjana M Stajić
Various neurodegenerative diseases are the main challenges to the modern medicine and there is a great need for novel, natural, neuroprotective agents. Ganoderma lucidum is a well-known medicinal mushroom which health benefits have been confirmed by numerous studies. As demand for its basidiocarps is increased and traditional cultivation on hardwoods is not environmentally-friendly and economically-justified, finding of alternative substrates is necessary. The aim of the study was to assess the effect of alternative cultivation substrates on the chemical profile of G...
April 6, 2018: Chemistry & Biodiversity
Chun-Hong Li, Hua-Li Zuo, Cen Chen, Yuan-Jia Hu, Zheng-Ming Qian, Wen-Jia Li, Zhi-Ning Xia, Feng-Qing Yang
Ganoderma lucidum (Chizhi in Chinese) is one of the most valuable and widely used medicinal fungi in traditional Chinese medicines (TCMs). Most of previous studies were focused on the triterpenoids and polysaccharides of G. lucidum, whereas less attention had been paid on the protein, which is another bioactive compound in it. In the present study, protein maps of fourteen G. lucidum samples were comprehensively analyzed by sodium dodecyl sulfate - polyacrylamide gel electrophoresis (SDS-PAGE) and two-dimensional electrophoresis (2-DE)...
March 2018: Pakistan Journal of Pharmaceutical Sciences
Chunhua Wang, Songsheng Shi, Quan Chen, Shuqian Lin, Rui Wang, Saizhen Wang, Chunmei Chen
Malignant gliomas are the most common brain tumors with high rates of recurrence and mortality. Novel approaches are in research, and immunotherapy emerges as a promising strategy. Recently, scientific attention has been focused on Ganoderma lucidum polysaccharides (GL-PS), one of the critical bioactive components of G lucidum, which have been recognized as a promising natural source of immunomodulatory and anticancer compounds. It remains unknown whether the GL-PS have any immunomodulatory and anticancer effects on brain glioma...
March 1, 2018: Integrative Cancer Therapies
Xiaoyan Tan, Junshe Sun, Huijuan Ning, Zifang Qin, Yuxin Miao, Tian Sun, Xiuqing Zhang
Ganoderma lucidum is a valuable basidiomycete with numerous pharmacological compounds, which is widely consumed throughout China. We previously found that the polysaccharide content of Ganoderma lucidum fruiting bodies could be significantly improved by 45.63% with treatment of 42 °C heat stress (HS) for 2 h. To further investigate genes involved in HS response and explore the mechanisms of HS regulating the carbohydrate metabolism in Ganoderma lucidum, high-throughput RNA-Seq was conducted to analyse the difference between control and heat-treated mycelia at transcriptome level...
March 29, 2018: Gene
Surya Sudheer, Ibrahim Alzorqi, Asgar Ali, Poh Guat Cheng, Yasmeen Siddiqui, Sivakumar Manickam
This study investigates the cultivation of Ganoderma lucidum using different agricultural biomasses from Malaysia. Five different combinations of rubber wood sawdust, empty fruit bunch fiber, and mesocarp fiber from oil palm, alone and in combination, were used to cultivate G. lucidum. Although all the substrate combinations worked well to grow the mushroom, the highest biological efficiency was obtained from the combination of empty fruit bunch fiber with sawdust. A total yield of 27% was obtained from empty fruit bunch fiber with sawdust, followed by sawdust (26%), empty fruit bunch fiber (19%), mesocarp fiber with sawdust (19%), and mesocarp fiber (16%)...
2018: International Journal of Medicinal Mushrooms
Rui Liu, Xue Zhang, Ang Ren, Deng-Ke Shi, Liang Shi, Jing Zhu, Han-Shou Yu, Ming-Wen Zhao
Heat stress (HS) is an important environmental factor that affects the growth and metabolism of edible fungi, but the molecular mechanism of the heat stress response (HSR) remains unclear. We previously reported that HS treatment increased the length between two hyphal branches and induced the accumulation of ganoderic acid biosynthesis and the gene expression of heat shock proteins (HSPs) in Ganoderma lucidum. In this study, we found that HS induced a significant increase in the cytosolic ROS concentration, and exogenously added ROS scavengers NAC, VC and NADPH oxidase (Nox) inhibitor DPI reduce the cytosolic ROS accumulation in G...
April 2018: Microbiological Research
Rui Liu, Liang Shi, Ting Zhu, Tao Yang, Ang Ren, Jing Zhu, Ming-Wen Zhao
We previously reported that high temperature impacts ganoderic acid (GA) biosynthesis in Ganoderma lucidum ( G. lucidum ) via Ca2+ Therefore, to further understand the signal regulating network of the organism's response to heat stress (HS), we examined the role of nitric oxide (NO) under HS. After HS treatment, the NO level was significantly increased by 120% compared with that under the control conditions. The application of a NO scavenger resulted in a 25% increase in GA compared with that found in the sample treated only with HS...
March 23, 2018: Applied and Environmental Microbiology
Yanfang Liu, Qingjiu Tang, Jingsong Zhang, Yongmei Xia, Yan Yang, Di Wu, Steve W Cui
β-D-glucan (GLP20) isolated from Ganoderma lucidum fruiting bodies was successfully fractionated into five fractions with different weight-average molecular weights (Mw ) through ultrasonic irradiation. The Mw , radius of gyration (Rg ), hydrodynamic radius (Rh ) and intrinsic viscosity ([η]) of these fractions in phosphate buffered saline (PBS) aqueous solution were determined using HPSEC-MALLS-RI-VS system. The results indicated that β-D-glucan displayed rigid chain conformations with ρ values lager than 2...
March 13, 2018: International Journal of Biological Macromolecules
Pengfei Guo, Yuejin Zhang, Yongjun Zhao
Abstract : Co-cultivation of microalgae and microbes for pollutant removal from sewage is considered as an effective wastewater treatment method. The aim of this study is to screen the optimal photoperiod, light intensity and microalgae co-cultivation method for simultaneously removing nutrients in biogas slurry and capturing CO₂ in biogas. The microalgae-fungi pellets are deemed to be a viable option because of their high specific growth rate and nutrient and CO2 removal efficiency under the photoperiod of 14 h light:10 h dark...
March 15, 2018: International Journal of Environmental Research and Public Health
Chunhua Wang, Dongmei Lin, Quan Chen, Shuqian Lin, Songsheng Shi, Chunmei Chen
The Ganoderma lucidum ( G. lucidum ) mushroom is one of the most extensively studied functional foods, known for its numerous health benefits, including the inhibition of tumor cell growth. The present study assessed the anti-proliferative and pro-apoptotic activity of a novel G. lucidum polysaccharide peptide (GL-PP) in human glioma U251 cells, which was purified from grass-cultured G. lucidum . GL-PP is a glycopeptide with an average molecular weight of 42,635 Da and a polysaccharide-to-peptide ratio of 88...
April 2018: Oncology Letters
Darija Cör, Željko Knez, Maša Knez Hrnčič
Ganoderma lucidum (Reishi) is a popular medicinal mushroom and has been used in oriental medicine because of its promoting effects on health and life expectancy. G. lucidum contains various compounds with a high grade of biological activty, which increase the immunity and show antitumour, antimicrobial, anti-inflammatory, antioxidant and acetylcholinesterase inhibitory activity. Several of these substances belong to the triterpenoids and polysaccharides classes. Proteins, lipids, phenols, sterols, etc. are also present...
March 13, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Runak Ghobadi, Rasoul Mohammadi, Javaher Chabavizade, Masoud Sami
Background: Ganoderma lucidum from Ganodermataceae family is a kind of mushroom known to have various therapeutic properties such as lowering high blood sugar and high blood pressure, boosting the immune system as well as its antibacterial and antioxidant effects. Materials and Methods: this study investigated the oxidative stability, microbial and sensory properties of sausage at three different treatments; (i) 1% w/w Ganoderma lucidum powder (GLP) without nitrite as a food preservative (P), (ii) 0...
2018: Advanced Biomedical Research
Shengli Wang, Liang Shi, Yanru Hu, Rui Liu, Ang Ren, Jing Zhu, Mingwen Zhao
The transcription factor Skn7 is a highly conserved fungal protein that participates in a variety of processes, including oxidative stress adaptation, fungicide sensitivity, cell wall biosynthesis, cell cycle, and sporulation. In this study, a homologous gene of Saccharomyces cerevisiae Skn7 was cloned from Ganoderma lucidum. RNA interference (RNAi) was used to study the functions of Skn7, and the two knockdown strains Skn7i-5 and Skn7i-7 were obtained in G. lucidum. The knockdown of GlSkn7 resulted in hypersensitivity to oxidative and cell wall stresses...
March 7, 2018: Fungal Genetics and Biology: FG & B
Oleg B Shevelev, Alisa A Seryapina, Evgenii L Zavjalov, Lyudmila A Gerlinskaya, Tatiana N Goryachkovskaya, Nikolay M Slynko, Leonid V Kuibida, Sergey E Peltek, Arcady L Markel, Mikhail P Moshkin
BACKGROUND: As the standard clinically used hypotensive medicines have many undesirable side effects, there is a need for new therapeutic agents, especially ones of a natural origin. PURPOSE: One possible candidate is extract from the mushroom Reishi (Ganoderma lucidum), which is used in the treatment and prevention of many chronic diseases. STUDY DESIGN AND METHODS: To study the effectiveness of Reishi, which grows in the Altai Mountains, as an antihypertensive agent, we intragastrically administered Reishi water extract to adult male hypertensive ISIAH (inherited stress-induced arterial hypertension) rats...
March 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Wen-Fang Wang, Han Xiao, Jian-Jiang Zhong
Ganoderic acid (GA), a triterpenoid from the traditional Chinese medicinal higher fungus Ganoderma lucidum, possesses antitumor and other significant pharmacological activities. Owing to the notorious difficulty and immaturity in genetic manipulation of higher fungi as well as their slow growth, biosynthesis of GAs in a heterologous host is an attractive alternative for their efficient bioproduction. In this study, using Saccharomyces cerevisiae as a host, we did a systematic screening of 72 candidates of cytochrome P450 monooxygenase (CYP450) genes from G...
February 24, 2018: Biotechnology and Bioengineering
Guang Zhang, Ang Ren, Liang Shi, Jing Zhu, Ailiang Jiang, Dengke Shi, Mingwen Zhao
The APSES transcription factors have been identified as key regulators of fungal development and other biological processes in fungi. In the present study, the function of Ganoderma lucidum GlSwi6, a homolog of Saccharomyces cerevisiae Swi6, was characterized. RNAi was used to examine the function of GlSwi6 in G. lucidum. Silencing GlSwi6 resulted in multiple developmental defects, including reduced fungal growth and increased hyphal branching, and the GlSwi6-silenced strains did not exhibit primordium or fruiting body formation...
March 2018: Microbiological Research
J A Chicatto, K T Rainert, M J Gonçalves, C V Helm, D Altmajer-Vaz, L B B Tavares
In this work we have assessed the decolorization of textile effluents throughout their treatment in a solid-state fermentation (SSF) system. SSF assays were conducted with peach-palm (Bactris gasipaes) residue using the white rot fungus Ganoderma lucidum EF 31. The influence of the dye concentration and of the amounts of peach-palm residue and liquid phase on both the discoloration efficiency and enzyme production was studied. According to our results, independently of experimental conditions employed, laccase was the main ligninolytic enzyme produced by G...
February 15, 2018: Brazilian Journal of Biology, Revista Brasleira de Biologia
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