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Ganoderma lucidum

Oleg B Shevelev, Alisa A Seryapina, Evgenii L Zavjalov, Lyudmila A Gerlinskaya, Tatiana N Goryachkovskaya, Nikolay M Slynko, Leonid V Kuibida, Sergey E Peltek, Arcady L Markel, Mikhail P Moshkin
The presented data contains information about component composition of lipophilic compounds in Ganoderma lucidum fungal body sample obtained using gas chromatography and subsequent mass spectrometry.
June 2018: Data in Brief
Xiaoxiao Lu, Yongzhi Liu, Linchao Zhao, Yongnan Liu, Mingwen Zhao
This study aimed to identify suitable reference genes under three chemical inducers, methyl jasmonate (MeJA), salicylic acid (SA) and hydrogen peroxide (H2 O2 ) in Ganoderma lucidum. In this study, expression stabilities of 14 candidate reference genes had been validated. Four algorithms were used: geNorm, NormFinder, BestKeeper, and RefFinder. Our results showed that, in short time, UCE2 (ubiquitin conjugating enzyme) was the most stable gene both in MeJA and H2 O2 treatments, ACTIN (beta-actin) was the most suitable reference gene for SA treatment...
June 12, 2018: World Journal of Microbiology & Biotechnology
Bing Wei, Ran Zhang, Jingbo Zhai, Junfeng Zhu, Fangli Yang, Dan Yue, Xiaoyi Liu, Changlong Lu, Xun Sun
Background: Ganoderma lucidum polysaccharides (GLP) has anti-inflammatory and immunomodulatory effects. Dysregulated immune responses are involved in the pathogenesis of dextran sulfate sodium (DSS)-induced colitis. The aim of this study was to assess the therapeutic potential of GLP to alleviate DSS-induced colitis. Methods: The mice were administered with GLP by intragastric gavage daily for two weeks prior to the DSS treatment. Mice were orally administered with 2...
2018: Journal of Immunology Research
Guo-Hui Wang, Xin Li, Wen-Hui Cao, Jing Li, Li-Hua Wang
This study firstly investigated the feasibility effect and safety of Ganoderma Lucidum Spore Powder (GLSP) for treating patients with epilepsy.Eighteen eligible patients with epilepsy were included. They all received GLSP treatment for a total of 8 weeks. The primary outcome included weekly seizure frequency. The secondary outcomes consisted of each seizure episode, and quality of life, measured by the Quality of Life in Epilepsy Inventory-31 (QOLIE-31), as well as the adverse events (AEs).After treatment, GLSP can significant reduce the weekly seizure frequency, compared with it before the treatment (P = ...
June 2018: Medicine (Baltimore)
Wei-Ling Guo, Yu-Yang Pan, Lu Li, Tian-Tian Li, Bin Liu, Xu-Cong Lv
The objective of this study was to investigate the effects of ethanol extract of Ganoderma lucidum (GL95) on hyperlipidaemia and gut microbiota, and its regulation mechanism in Wistar rats fed on a high-fat diet (HFD). UPLC-QTOF MS indicated that GL95 was enriched with triterpenoids, especially ganoderic acids. The results of the animal experiment showed that oral administration of GL95 markedly alleviated the dyslipidemia through decreasing the levels of serum total triglyceride (TG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), and inhibiting hepatic lipid accumulation and steatosis...
June 7, 2018: Food & Function
Paola Rossi, Raffaele Difrancia, Vincenzo Quagliariello, Elena Savino, Paolo Tralongo, Cinzia Lucia Randazzo, Massimiliano Berretta
Culinary and medicinal mushrooms are widely used in Asian countries, both as dietary supplements and as nutraceutical foods. They have recently become popular in Europe, as well, for their nutritional and health benefits. In particular, epidemiological studies conducted in Asia suggest that mushroom intake, together with other phytotherapy substances, protects against cancer, specifically gastrointestinal (GI) and breast cancers. Most of the data come from in vitro studies and in vivo experimental animal models...
May 15, 2018: Oncotarget
Chaima Bouzgarrou, Khira Amara, Filipa S Reis, João C M Barreira, Fethia Skhiri, Noureddine Chatti, Anabela Martins, Lillian Barros, Isabel C F R Ferreira
Consumers are well-informed about food additives and it is likely that they prefer natural additives over their synthetic analogues. Antioxidants represent a major class of food preservatives, among which tocopherols stand out as one of the most important examples. Interestingly, these compounds are present in relevant amounts in the mycelia of in vitro cultured mushrooms. Accordingly, the mycelia from Ganoderma lucidum, Pleurotus ostreatus and Pleurotus eryngii were used as alternative sources of tocopherols...
June 4, 2018: Food & Function
Md Sakib Hossen, Md Maruf Billah Prince, E M Tanvir, M Alamgir Zaman Chowdhury, Md Abdur Rahman, Fahmida Alam, Sudip Paul, Moumoni Saha, Md Yousuf Ali, Nikhil Chandra Bhoumik, Nurul Karim, Siew Hua Gan, Md Ibrahim Khalil
The current study aimed to investigate the ameliorative effects of two types of mushrooms, Ganoderma lucidum (GL) and Auricularia polytricha (AP), against carbofuran- (CF) induced toxicity in rats. Male Wistar rats ( n = 42) were divided into six equal groups. The rats in the negative control group received oral administration of CF at 1 mg/kg with the normal diet for 28 days. The treatment groups received oral administration of ethanolic extract of GL or AP at 100 mg/kg followed by coadministration of CF at 1 mg/kg with the normal diet for the same experimental period, respectively...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Shuai Zhou, Jingsong Zhang, Fuying Ma, Chuanhong Tang, Qingjiu Tang, Xiaoyu Zhang
Ganoderma lucidum is a medicinal mushroom that is well known for its ability to enhance human health, and products made from this fungus have been highly profitable. The substrate-degrading ability of G. lucidum could be related to its growth. CAZy proteins were more abundant in its genome than in the other white rot fungi models. Among these CAZy proteins, changes in lignocellulolytic enzymes during growth have not been well studied. Using genomic, transcriptomic and secretomic analyses, this study focuses on the lignocellulolytic enzymes of G...
2018: PloS One
Pei-Ling Hsu, Yung-Ching Lin, Hao Ni, Fan-E Mo
Ganoderma mushrooms, used in traditional Chinese medicine to promote health and longevity, have become widely accepted as herbal supplements. Ganoderma lucidum (GL), a commonly seen ganoderma species, is commercially cultivated under controlled conditions for more consistent chemical composition. The medicinal properties of GL are attributable to its antioxidant and anti-inflammatory activities. We intended to assess the effect of GL in atherosclerosis, an arterial condition associated with chronic oxidative stress and inflammation, using a carotid-artery-ligation mouse model...
2018: Oxidative Medicine and Cellular Longevity
Lin Zheng, Yum-Shing Wong, Mumin Shao, Shiying Huang, Fochang Wang, Jianping Chen
9,11-Dehydroergosterol peroxide [9(11)-DHEP] is an important steroid from medicinal mushroom, which has been reported to exert antitumor activity in several tumor types. However, the role of 9(11)‑DHEP toward the malignant melanoma cells has not been investigated. In the present study, the steroid from Ganoderma lucidum was purified on a submerged culture, and its antitumor mechanisms on A375 human malignant melanoma cells was investigated by MTT, flow cytometry and western blotting. The studies demonstrated that apoptotic mechanisms of the steroid were caspase‑dependent and mediated via the mitochondrial pathway...
May 17, 2018: Molecular Medicine Reports
Valentina Perna, Jane W Agger, Jesper Holck, Anne S Meyer
Laccases (EC are enzymes known for their ability to catalyse the oxidation of phenolic compounds using molecular oxygen as the final electron acceptor. Lignin is a natural phenylpropanoids biopolymer whose degradation in nature is thought to be aided by enzymatic oxidation by laccases. Laccase activity is often measured spectrophotometrically on compounds such as syringaldazine and ABTS which poorly relate to lignin. We employed natural phenolic hydroxycinnamates having different degree of methoxylations, p-coumaric, ferulic and sinapic acid, and a lignin model OH-dilignol compound as substrates to assess enzyme kinetics by HPLC-MS on two fungal laccases Trametes versicolor laccase, Tv and Ganoderma lucidum laccase, Gl...
May 25, 2018: Scientific Reports
Jaqueline da Silva Coelho-Moreira, Tatiane Brugnari, Anacharis B Sá-Nakanishi, Rafael Castoldi, Cristina G M de Souza, Adelar Bracht, Rosane M Peralta
The white rot basidiomycete Ganoderma lucidum was evaluated for its capability to tolerate and to degrade the herbicide diuron. Diuron at a subtoxic concentration was added at the start of the cultivation in glucose liquid stationary cultures. Under this condition diuron was a laccase inducer. Almost 50% of the initially present diuron was removed after 15 d of cultivation. Two diuron metabolites were found N'-(3,4-dichlorophenyl)-N-methylurea (DCPMU) and 3,4-dichlorophenylurea (DCPU). The addition of the cytochrome P450 inhibitors 1-aminobenzotriazole and piperonyl butoxide reduced significantly the capability of the fungus in degrading diuron...
June 2018: Fungal Biology
Bhavini Kumari, Rekha Kumari, Prolay Das
G-quadruplexes are secondary DNA structures frequently found in telomeres and DNA sequences related to gene regulation, etc. Herein, we report a label free, sensitive and visually detectable fluorescence based biosensing platform for the detection of G-quadruplexes in DNA. Highly fluorescent N-doped carbon quantum dot (CD) with enriched functional groups was synthesized from Ganoderma lucidum, an oriental fungus by using a green hydrothermal process. Noncovalent functionalization of CD was done with Hemin where Hemin/CD conjugate forms a quenched union...
May 17, 2018: Journal of Pharmaceutical and Biomedical Analysis
A I Perfileva, O M Tsivileva, Ya B Drevko, D N Ibragimova, O V Koftin
The impact of selenium biocomposites obtained from the medicinal macrobasidiomycetes Ganoderma lucidum, Grifola umbellata, Laetiporus sulphureus, Lentinula edodes, and Pleurotus ostreatus on the viability and biofilm formation capability of the phytopathogenic Gram-positive bacterium Clavibacter michiganensis ssp. sepedonicus (Spieck. et Kotth.) (Cms) was studied. Impairment of bacterial cell viability resulting from their incubation with biocomposites was shown. The decisive role of the composites' selenium component on the biological activity under question was established...
March 2018: Doklady Biological Sciences: Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections
J W M Yuen, D S Y Mak, E S Chan, M D I Gohel, C F Ng
ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (GL) has been traditionally used in oriental medicine as superior health tonic, and there are numerous scientific evidences of its antitumorigenic activities. AIM OF THE STUDY: To evaluate the intravesical chemopreventive effects of ethanol extract of GL (GLe) on bladder cancer. MATERIALS AND METHODS: Intravesical therapy is defined as the direct instillation of a liquid drug into bladder through a catheter...
September 15, 2018: Journal of Ethnopharmacology
Qi-Zhang Li, Yu-Zhou Chang, Kai-Qi Su, Xiao-Lei Wang, Xiao-Hui Bai, Xuan-Wei Zhou
Ganoderma mushrooms for medicinal use contain various bioactive compounds, but the genetic elements available for these medicinal mushrooms are still limited. In this study we cloned and analyzed the promoters of fungal immunomodulatory protein (FIP) genes from G. lucidum and G. atrum. FIP gene expression was induced by different concentrations of methyl jasmonate (MeJA) and salicylic acid (SA), and messenger RNA expression was detected by quantitative reverse-transcription polymerase chain reaction. The results provided 5' upstream sequences of FIP genes from G...
2018: International Journal of Medicinal Mushrooms
Hazwani Mat Saad, Kae Shin Sim, Yee Shin Tan
Five culinary-medicinal mushrooms are commonly available in the Malaysian market: Agaricus bisporus (white and brown), Ganoderma lucidum, Hypsizygus marmoreus, Pleurotus floridanus, and P. pulmonarius. These species were selected for use in the current study, the aim of which was to investigate the antimelanogenesis and anti-inflammatory activity of these mushrooms in an attempt to evaluate their potential use in cosmeceuticals. Mushroom fruiting bodies were extracted with hot water, and the extracts were freeze-dried before testing...
2018: International Journal of Medicinal Mushrooms
Na Feng, Yutian Wei, Jie Feng, Qingjiu Tang, Zhong Zhang, Jingsong Zhang, Han Wei
Ganoderic acid S, ganoderic acid T, and ganoderal B are the main bioactive triterpenes of Ganoderma lucidum. In this study, mycelia of Ganoderma lucidum were obtained by two-stage fermentation and then extracted by ethanol and petroleum ether sequentially to obtain crude triterpenes. The crude sample was further purified by recycling high-speed counter-current chromatography (HSCCC) with n-hexane: ethyl acetate: methanol: water (7:12:11:5, v/v/v/v) as the optimized two-phase solventsystem. 16.4 mg of ganoderol B with the purity of 90...
May 10, 2018: Biomedical Chromatography: BMC
Marwa M Abu-Serie, Noha H Habashy, Wafaa E Attia
BACKGROUND: Since oxidative stress and inflammation are two linked factors in the pathogenesis of several human diseases. Thus identification of effective treatment is of great importance. Edible mushroom and microalgae are rich in the effective antioxidant phytochemicals. Hence, their beneficial effects on oxidative stress-associated inflammation are extremely required to be investigated. METHODS: This study evaluated the functional constituents, antioxidant and anti-inflammatory activities of Malaysian Ganoderma lucidum aqueous extract (GLE) and Egyptian Chlorella vulgaris ethanolic extract (CVE)...
May 10, 2018: BMC Complementary and Alternative Medicine
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