keyword
https://read.qxmd.com/read/38019808/the-healthy-hearts-project-development-and-evaluation-of-a-website-for-cardiovascular-risk-assessment-and-visualisation-and-self-management-through-healthy-lifestyle-goal-setting
#21
JOURNAL ARTICLE
Imogen Rogers, Tom Grice-Jackson, Elizabeth Ford, John Howat, Remya Salimkumar, Kat Frere-Smith, Nicola O'Connor, Hilde Bastiaens, Harm van Marwijk
Materially deprived communities in the UK have excess morbidity and mortality from cardiovascular disease (CVD) but are less likely to engage with formal care pathways. Community engagement and e-health may be more effective ways to promote risk-reducing lifestyle change. The "Healthy Hearts Project" website was designed for use by community health workers (CHWs) for cardiovascular risk assessment and lifestyle goal setting, or for independent use by community members. This paper describes the website's development and evaluation...
November 2023: PLOS Digit Health
https://read.qxmd.com/read/38016473/an-evolutionary-perspective-on-complex-neuropsychiatric-disease
#22
REVIEW
J M McClellan, Anthony W Zoghbi, Joseph D Buxbaum, Carolina Cappi, James J Crowley, Jonathan Flint, Dorothy E Grice, Suleyman Gulsuner, Conrad Iyegbe, Sanjeev Jain, Po-Hsiu Kuo, Maria Claudia Lattig, Maria Rita Passos-Bueno, Meera Purushottam, Dan J Stein, Anna B Sunshine, Ezra S Susser, Christopher A Walsh, Olivia Wootton, Mary-Claire King
The forces of evolution-mutation, selection, migration, and genetic drift-shape the genetic architecture of human traits, including the genetic architecture of complex neuropsychiatric illnesses. Studying these illnesses in populations that are diverse in genetic ancestry, historical demography, and cultural history can reveal how evolutionary forces have guided adaptation over time and place. A fundamental truth of shared human biology is that an allele responsible for a disease in anyone, anywhere, reveals a gene critical to the normal biology underlying that condition in everyone, everywhere...
November 27, 2023: Neuron
https://read.qxmd.com/read/38007871/do-distributions-of-diamondoid-hydrocarbons-accumulated-in-oil-contaminated-fish-tissues-help-to-identify-the-sources-of-oil
#23
JOURNAL ARTICLE
Alan G Scarlett, Francis D Spilsbury, Steven J Rowland, Marthe Monique Gagnon, Kliti Grice
Identifying the sources of environmental oil contamination can be challenging, especially for oil in motile organisms such as fish. Lipophilic hydrocarbons from oil can bioaccumulate in fish adipose tissue and potentially provide a forensic "fingerprint" of the original oil. Herein, diamondoid hydrocarbon distributions were employed to provide such fingerprints. Indices produced from diamondoids were used to compare extracts from fish adipose tissues and the crude and fuel oils to which the fish were exposed under laboratory conditions...
November 25, 2023: Marine Pollution Bulletin
https://read.qxmd.com/read/38007580/robust-mapping-of-spatiotemporal-trajectories-and-cell-cell-interactions-in-healthy-and-diseased-tissues
#24
JOURNAL ARTICLE
Duy Pham, Xiao Tan, Brad Balderson, Jun Xu, Laura F Grice, Sohye Yoon, Emily F Willis, Minh Tran, Pui Yeng Lam, Arti Raghubar, Priyakshi Kalita-de Croft, Sunil Lakhani, Jana Vukovic, Marc J Ruitenberg, Quan H Nguyen
Spatial transcriptomics (ST) technologies generate multiple data types from biological samples, namely gene expression, physical distance between data points, and/or tissue morphology. Here we developed three computational-statistical algorithms that integrate all three data types to advance understanding of cellular processes. First, we present a spatial graph-based method, pseudo-time-space (PSTS), to model and uncover relationships between transcriptional states of cells across tissues undergoing dynamic change (e...
November 25, 2023: Nature Communications
https://read.qxmd.com/read/37990173/neurophysiological-explorations-across-the-spectrum-of-psychosis-autism-and-depression-during-wakefulness-and-sleep-protocol-of-a-prospective-case-control-transdiagnostic-multimodal-study-demeter
#25
JOURNAL ARTICLE
Valeria Lucarini, Anaëlle Alouit, Delphine Yeh, Jeanne Le Coq, Romane Savatte, Mylène Charre, Cécile Louveau, Meryem Benlaifa Houamri, Sylvain Penaud, Alexandre Gaston-Bellegarde, Stéphane Rio, Laurent Drouet, Maxime Elbaz, Jean Becchio, Sylvain Pourchet, Estelle Pruvost-Robieux, Angela Marchi, Mylène Moyal, Aline Lefebvre, Boris Chaumette, Martine Grice, Påvel G Lindberg, Lucile Dupin, Pascale Piolino, Cédric Lemogne, Damien Léger, Martine Gavaret, Marie-Odile Krebs, Anton Iftimovici
BACKGROUND: Quantitative electroencephalography (EEG) analysis offers the opportunity to study high-level cognitive processes across psychiatric disorders. In particular, EEG microstates translate the temporal dynamics of neuronal networks throughout the brain. Their alteration may reflect transdiagnostic anomalies in neurophysiological functions that are impaired in mood, psychosis, and autism spectrum disorders, such as sensorimotor integration, speech, sleep, and sense of self. The main questions this study aims to answer are as follows: 1) Are EEG microstate anomalies associated with clinical and functional prognosis, both in resting conditions and during sleep, across psychiatric disorders? 2) Are EEG microstate anomalies associated with differences in sensorimotor integration, speech, sense of self, and sleep? 3) Can the dynamic of EEG microstates be modulated by a non-drug intervention such as light hypnosis? METHODS: This prospective cohort will include a population of adolescents and young adults, aged 15 to 30 years old, with ultra-high-risk of psychosis (UHR), first-episode psychosis (FEP), schizophrenia (SCZ), autism spectrum disorder (ASD), and major depressive disorder (MDD), as well as healthy controls (CTRL) (N = 21 × 6), who will be assessed at baseline and after one year of follow-up...
November 21, 2023: BMC Psychiatry
https://read.qxmd.com/read/37979774/laser-capture-microdissection-based-rnaseq-for-profiling-mouse-and-human-sebaceous-gland-transcriptomes
#26
JOURNAL ARTICLE
Jordan C Harris, Stephen M Prouty, Molly A Nelson, Derek C Sung, Amanda M Nelson, John T Seykora, Taku Kambayashi, Elizabeth A Grice
No abstract text is available yet for this article.
November 16, 2023: Journal of Investigative Dermatology
https://read.qxmd.com/read/37976199/language-artificial-intelligences-communicative-performance-quantified-through-the-gricean-conversation-theory
#27
JOURNAL ARTICLE
Yunju Nam, Hyenyeong Chung, Upyong Hong
This study pragmatically investigates an artificial intelligence (AI) speaker (AIS)'s verbal communicative performance based on real AI-human conversation data. Specifically, this study explores Grice's conversation theory, which enables the categorization of an AIS's mistaken utterances as violations of specific conversational maxims. Twenty native Korean-speaking participants recorded at least 50 conversations with Kakao Mini AISs, provided by Daum Kakao, Inc., in Korea. Each conversation, either for information sharing or as daily dialogue, was required to contain at least two turn-taking instances...
November 17, 2023: Cyberpsychology, Behavior and Social Networking
https://read.qxmd.com/read/37963973/rapid-encapsulation-of-true-ferns-and-arborane-fernane-compounds-fossilised-in-siderite-concretions-supports-analytical-distinction-of-plant-fossils
#28
JOURNAL ARTICLE
Madison Tripp, Lorenz Schwark, Jochen J Brocks, Paul Mayer, Jessica H Whiteside, William Rickard, Paul F Greenwood, Kliti Grice
Fossilised true ferns (Pecopteris sp.) preserved in siderite concretions from the Mazon Creek Lagerstätte (Illinois) presented a unique opportunity to characterise the organic signatures of these late Carboniferous plants. Localised analyses of true fern fossils showed several highly abundant phytohopanoids and fernane/arborane derived aromatic products, which were present only negligibly within their siderite matrix, as well as from other types of fossilised plants. These terpenoids had been recognised in some extant ferns, but scarcely in sedimentary organic matter and their exact source remained ambiguous...
November 13, 2023: Scientific Reports
https://read.qxmd.com/read/37961145/extracellular-domain-hinge-and-transmembrane-determinants-affecting-surface-cd4-expression-of-a-novel-anti-hiv-chimeric-antigen-receptor-car-construct
#29
Giorgio Zenere, Chengxiang Wu, Cecily C Midkiff, Nathan M Johnson, Christopher P Grice, William C Wimley, Amitinder Kaur, Stephen E Braun
Chimeric antigen receptor (CAR)-T cells have demonstrated clinical potential, but current receptors still need improvements to be successful against chronic HIV infection. In this study, we address some requirements of CAR motifs for strong surface expression of a novel anti-HIV CAR by evaluating important elements in the extracellular, hinge, and transmembrane (TM) domains. When combining a truncated CD4 extracellular domain and CD8α hinge/TM, the novel CAR did not express extracellularly but was detectable intracellularly...
October 26, 2023: bioRxiv
https://read.qxmd.com/read/37946624/latin-american-trans-ancestry-initiative-for-ocd-genomics-latino-study-protocol
#30
JOURNAL ARTICLE
James J Crowley, Carolina Cappi, Marcos E Ochoa-Panaifo, Renee M Frederick, Minjee Kook, Andrew D Wiese, Diana Rancourt, Elizabeth G Atkinson, Paola Giusti-Rodriguez, Jacey L Anderberg, Jonathan S Abramowitz, Victor R Adorno, Cinthia Aguirre, Gilberto S Alves, Gustavo S Alves, NaEshia Ancalade, Alejandro A Arellano Espinosa, Paul D Arnold, Daphne M Ayton, Izabela G Barbosa, Laura Marcela Barón Castano, Cynthia N Barrera, María Celeste Berardo, Dayan Berrones, John R Best, Tim B Bigdeli, Christie L Burton, Joseph D Buxbaum, Jennifer L Callahan, Maria Cecília B Carneiro, Sandra L Cepeda, Evelyn Chazelle, Jessica M Chire, Macarena Churruca Munoz, Pamela Claisse Quiroz, Journa Cobite, Jonathan S Comer, Daniel L Costa, Jennifer Crosbie, Victor O Cruz, Guillermo Dager, Luisa F Daza, Anabel de la Rosa-Gómez, Daniela Del Río, Fernanda Z Delage, Carolina B Dreher, Lucila Fay, Tomas Fazio, Ygor A Ferrão, Gabriela M Ferreira, Edith G Figueroa, Leonardo F Fontenelle, Diego A Forero, Daniele T H Fragoso, Bharathi S Gadad, Sheldon R Garrison, Andres González, Laura D Gonzalez, Marco A González, Polaris Gonzalez-Barrios, Wayne K Goodman, Dorothy E Grice, Jerry Guintivano, Daniel G Guttfreund, Andrew G Guzick, Matthew W Halvorsen, Joseph D Hovey, Hailiang Huang, Jonathan Irreño-Sotomonte, Reinhard Janssen-Aguilar, Matias Jensen, Alexandra Z Jimenez Reynolds, Joali Alexandra Juárez Lujambio, Nasim Khalfe, Madison A Knutsen, Caleb Lack, Nuria Lanzagorta, Monicke O Lima, Melanie O Longhurst, David A Lozada Martinez, Elba S Luna, Andrea H Marques, Molly S Martinez, Maria de Los Angeles Matos, Caitlyn E Maye, Joseph F McGuire, Gabriela Menezes, Charlene Minaya, Tomás Miño, Sara M Mithani, Circe Montes de Oca, Alonso Morales-Rivero, Maria E Moreira-de-Oliveira, Olivia J Morris, Sandra I Muñoz, Zainab Naqqash, Ambar A Núñez Bracho, Belinda E Núñez Bracho, Maria Corina Ochoa Rojas, Luis A Olavarria Castaman, Trinidad Olivos Balmaceda, Iliana Ortega, Darpan I Patel, Ainsley K Patrick, Mariel Paz Y Mino, Jose L Perales Orellana, Bárbara Perdigão Stumpf, Tamara Peregrina, Tania Pérez Duarte, Kelly L Piacsek, Maritza Placencia, María Belén Prieto, Lucas C Quarantini, Yana Quarantini-Alvim, Renato T Ramos, Iaroslava C Ramos, Vanessa R Ramos, Kesley A Ramsey, Elise V Ray, Margaret A Richter, Bradley C Riemann, Juan C Rivas, Maria C Rosario, Camilo J Ruggero, Angel A Ruiz-Chow, Alejandra Ruiz-Velasco, Melisa N Sagarnaga, Aline S Sampaio, Leonardo C Saraiva, Russell J Schachar, Sophie C Schneider, Ethan J Schweissing, Laura D Seligman, Roseli G Shavitt, Keaton J Soileau, S Evelyn Stewart, Shaina B Storch, Emily R Strouphauer, Vissente Tapia Cuevas, Kiara R Timpano, Beatriz Treviño-de la Garza, Alexie Vallejo-Silva, Javier Vargas-Medrano, María I Vásquez, Guadalupe Vidal Martinez, Saira A Weinzimmer, Mauricio A Yanez, Gwyneth Zai, Lina M Zapata-Restrepo, Luz M Zappa, Raquel M Zepeda-Burgos, Anthony W Zoghbi, Euripedes C Miguel, Carolyn I Rodriguez, Mayra C Martinez Mallen, Pablo R Moya, Tania Borda, María Beatriz Moyano, Manuel Mattheisen, Stacey Pereira, Gabriel Lázaro-Muñoz, Karen G Martinez-Gonzalez, Michele T Pato, Humberto Nicolini, Eric A Storch
Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long-sought risk loci, but >95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics...
November 9, 2023: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://read.qxmd.com/read/37921491/complete-genome-sequence-of-the-bacterium-desemzia-incerta-isolated-from-the-dorsal-skin-of-a-yucatan-pig
#31
JOURNAL ARTICLE
Monica Wei, Simon A B Knight, Laurice Flowers, Jasmine Walsh, Elizabeth Grice
We have shown previously that an isolate of Desemzia incerta from porcine skin has antimicrobial activity against methicillin-resistant Staphylococcus aureus . We present here the complete D. incerta genome containing one circular chromosome and five circular plasmids.
November 3, 2023: Microbiology Resource Announcements
https://read.qxmd.com/read/37917111/a-pilot-nonrandomized-controlled-trial-examining-the-use-of-artificial-tears-on-the-radioactivity-of-tears-after-radioactive-iodine-treatment-for-thyroid-cancer
#32
JOURNAL ARTICLE
Irene T Lee, Jared V Grice, Xiangyu Ji, Qingxia Chen, Lindsay A Bischoff, Aaron C Jessop, Behin Barahimi, Francois Codere, Louise A Mawn, Rachel K Sobel
Background: Nasolacrimal duct obstruction (NLDO) is an adverse effect of high dose radioactive iodine (RAI) therapy for thyroid carcinoma. There are currently no established preventive measures. This study assesses whether preservative free artificial tears (PFATs) can decrease the 131 I sodium iodide (131 I) activity in the tears of patients following RAI therapy for thyroid carcinoma, and potentially serve as a preventive measure for RAI-associated NLDO. Methods: This non-randomized prospective pilot clinical trial recruited contact-lens wearing patients undergoing RAI therapy for thyroid cancer to self-administer PFATs into the right eye for four days starting on the day of RAI ingestion...
January 2024: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/37873232/an-exploration-of-mechanisms-underlying-desemzia-incerta-colonization-resistance-to-methicillin-resistant-staphylococcus-aureus-on-the-skin
#33
Monica Wei, Simon Ab Knight, Hossein Fazelinia, Lynn Spruce, Jennifer Roof, Emily Chu, Jasmine Walsh, Laurice Flowers, Daniel Y Kim, Jun Zhu, Elizabeth A Grice
UNLABELLED: Colonization of human skin and nares by methicillin-resistant Staphylococcus aureus (MRSA) leads to community spread of MRSA. This spread is exacerbated by transfer of MRSA between humans and livestock, particularly swine. Here we capitalized on the shared features between human and porcine skin, including shared MRSA colonization, to study novel bacterial mediators of MRSA colonization resistance. We focused on the poorly studied bacterial species Desemzia incerta , which we found to exert antimicrobial activity through a secreted product and exhibited colonization resistance against MRSA in an in vivo murine skin model...
October 11, 2023: bioRxiv
https://read.qxmd.com/read/37871833/partition-dosimetry-and-outcomes-of-metastatic-neuroendocrine-tumors-following-yttrium-90-resin-microsphere-radioembolization
#34
JOURNAL ARTICLE
Patrick W Doyle, C Spencer Workman, Jared V Grice, Trey W McGonigle, Shi Huang, Anthony J Borgmann, Jennifer C Baker, Jason E Taylor, Daniel B Brown
PURPOSE: To characterize estimated average tumor absorbed dose (ADT ) and objective response neuroendocrine tumor (NET) following resin microspheres Yttrium-90 (Y90) radioembolization utilizing partition dosimetry. MATERIALS AND METHODS: In this retrospective, single-center study, multicompartment dosimetry of index tumors receiving Y90 radioembolization between 2013-2022 used MIM SurePlan and technetium-99m macroaggregated albumin single-photon emission computed tomography combined with computed tomography...
October 21, 2023: Journal of Vascular and Interventional Radiology: JVIR
https://read.qxmd.com/read/37858460/variable-staphyloxanthin-production-by-staphylococcus-aureus-drives-strain-dependent-effects-on-diabetic-wound-healing-outcomes
#35
JOURNAL ARTICLE
Amy E Campbell, Amelia R McCready-Vangi, Aayushi Uberoi, Sofía M Murga-Garrido, Victoria M Lovins, Ellen K White, Jamie Ting-Chun Pan, Simon A B Knight, Alexis R Morgenstern, Colleen Bianco, Paul J Planet, Sue E Gardner, Elizabeth A Grice
Strain-level variation in Staphylococcus aureus is a factor that contributes to disease burden and clinical outcomes in skin disorders and chronic wounds. However, the microbial mechanisms that drive these variable host responses are poorly understood. To identify mechanisms underlying strain-specific outcomes, we perform high-throughput phenotyping screens on S. aureus isolates cultured from diabetic foot ulcers. Isolates from non-healing wounds produce more staphyloxanthin, a cell membrane pigment. In murine diabetic wounds, staphyloxanthin-producing isolates delay wound closure significantly compared with staphyloxanthin-deficient isolates...
October 17, 2023: Cell Reports
https://read.qxmd.com/read/37851822/multiomic-profiling-of-cutaneous-leishmaniasis-infections-reveals-microbiota-driven-mechanisms-underlying-disease-severity
#36
JOURNAL ARTICLE
Camila Farias Amorim, Victoria M Lovins, Tej Pratap Singh, Fernanda O Novais, Jordan C Harris, Alexsandro S Lago, Lucas P Carvalho, Edgar M Carvalho, Daniel P Beiting, Phillip Scott, Elizabeth A Grice
Leishmania braziliensis is a parasitic infection that can result in inflammation and skin injury with highly variable and unpredictable clinical outcomes. Here, we investigated the potential impact of microbiota on infection-induced inflammatory responses and disease resolution by conducting an integrated analysis of the skin microbiome and host transcriptome on a cohort of 62 patients infected with L. braziliensis . We found that overall bacterial burden and microbiome configurations dominated with Staphylococcus spp...
October 18, 2023: Science Translational Medicine
https://read.qxmd.com/read/37840715/microbially-mediated-fossil-concretions-and-their-characterization-by-the-latest-methodologies-a-review
#37
REVIEW
Navdeep K Dhami, Paul F Greenwood, Stephen F Poropat, Madison Tripp, Amy Elson, Hridya Vijay, Luke Brosnan, Alex I Holman, Matthew Campbell, Peter Hopper, Lisa Smith, Andrew Jian, Kliti Grice
The study of well-preserved organic matter (OM) within mineral concretions has provided key insights into depositional and environmental conditions in deep time. Concretions of varied compositions, including carbonate, phosphate, and iron-based minerals, have been found to host exceptionally preserved fossils. Organic geochemical characterization of concretion-encapsulated OM promises valuable new information of fossil preservation, paleoenvironments, and even direct taxonomic information to further illuminate the evolutionary dynamics of our planet and its biota...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/37812390/regulatory-t-cells-control-staphylococcus-aureus-and-disease-severity-of-cutaneous-leishmaniasis
#38
JOURNAL ARTICLE
Tej Pratap Singh, Camila Farias Amorim, Victoria M Lovins, Charles W Bradley, Lucas P Carvalho, Edgar M Carvalho, Elizabeth A Grice, Phillip Scott
Cutaneous leishmaniasis causes alterations in the skin microbiota, leading to pathologic immune responses and delayed healing. However, it is not known how these microbiota-driven immune responses are regulated. Here, we report that depletion of Foxp3+ regulatory T cells (Tregs) in Staphylococcus aureus-colonized mice resulted in less IL-17 and an IFN-γ-dependent skin inflammation with impaired S. aureus immunity. Similarly, reducing Tregs in S. aureus-colonized and Leishmania braziliensis-infected mice increased IFN-γ, S...
December 4, 2023: Journal of Experimental Medicine
https://read.qxmd.com/read/37786632/recruitment-of-medical-graduates-from-prague-to-foundation-programme-jobs-in-a-uk-hospital-results-of-a-6-year-project
#39
JOURNAL ARTICLE
Rute Castelhano, Varun Kakkar, Carolyn McKinlay, Kirsty Nelson-Smith, Jessica Daniel, John Grice, Alexander Ashmore, David Woods
INTRODUCTION: International medical graduates (IMGs) are required to fill foundation-level posts in the NHS. Recruiting for these posts is difficult and time consuming. In 2016, we created a link between the Great Western Hospital, Swindon and Charles University, Prague to recruit to these posts. Here, we describe in detail the recruitment process, level of support and outcomes after 6 years, including the success rate of completion of foundation training and their career progression...
July 2023: Future Healthcare Journal
https://read.qxmd.com/read/37764476/dihydroxyphenyl-and-heteroaromatic-based-thienopyrimidinones-to-tackle-hiv-1-ledgf-p75-dependent-in-activity
#40
JOURNAL ARTICLE
Graziella Tocco, Serena Canton, Antonio Laus, Pierluigi Caboni, Stuart F J Le Grice, Enzo Tramontano, Francesca Esposito
The spread of Human Immunodeficiency Virus (HIV) still represents a global public health issue of major concern, and would benefit from unveiling unique viral features as targets for drug design. In this respect, HIV-1 integrase (IN), due to the absence of homologs in human cells, is a popular target for the synthesis of novel selective compounds. Moreover, as drug-resistant viral strains are rapidly evolving, the development of novel allosteric inhibitors is acutely required. Recently, we have observed that Kuwanon-L, quinazolinones and thienopyrimidinones containing at least one polyphenol unit, effectively inhibited HIV-1 IN activity...
September 19, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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