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https://www.readbyqxmd.com/read/27902764/movement-patterns-home-range-size-and-habitat-selection-of-an-endangered-resource-tracking-species-the-black-throated-finch-poephila-cincta-cincta
#1
Juliana Rechetelo, Anthony Grice, April Elizabeth Reside, Britta Denise Hardesty, James Moloney
Understanding movement patterns and home range of species is paramount in ecology; it is particularly important for threatened taxa as it can provide valuable information for conservation management. To address this knowledge gap for a range-restricted endangered bird, we estimated home range size, daily movement patterns and habitat use of a granivorous subspecies in northeast Australia, the black-throated finch (Poephila cincta cincta; BTF) using radio-tracking and re-sighting of colour banded birds. Little is known about basic aspects of its ecology including movement patterns and home range sizes...
2016: PloS One
https://www.readbyqxmd.com/read/27882274/mechanics-of-wound-closure-emerging-tape-based-wound-closure-technology-vs-traditional-methods
#2
Kemal Levi, Kei Ichiryu, Pelin Kefel, Juergen Keller, Jon Grice, Ori Belson, Eric Storne, Bauback Safa
To date, there is still a lack of understanding of how wound closure methods perform comparatively under daily bodily movement during the course of healing and how they affect the mechanics of healing. The present study is a first step in understanding and objectively quantifying the gap. The study provides both a new method of metrology for noninvasive evaluation of skin mechanics at the onset of wound healing and an emerging tape-based wound closure technology. The latter shows better performance with respect to commonly used staples and sutures, holding the wound intact and providing uniform mechanical support across the incision...
October 12, 2016: Curēus
https://www.readbyqxmd.com/read/27799831/skin-models-for-the-testing-of-transdermal-drugs
#3
REVIEW
Eman Abd, Shereen A Yousef, Michael N Pastore, Krishna Telaprolu, Yousuf H Mohammed, Sarika Namjoshi, Jeffrey E Grice, Michael S Roberts
The assessment of percutaneous permeation of molecules is a key step in the evaluation of dermal or transdermal delivery systems. If the drugs are intended for delivery to humans, the most appropriate setting in which to do the assessment is the in vivo human. However, this may not be possible for ethical, practical, or economic reasons, particularly in the early phases of development. It is thus necessary to find alternative methods using accessible and reproducible surrogates for in vivo human skin. A range of models has been developed, including ex vivo human skin, usually obtained from cadavers or plastic surgery patients, ex vivo animal skin, and artificial or reconstructed skin models...
2016: Clinical Pharmacology: Advances and Applications
https://www.readbyqxmd.com/read/27798266/focally-perfused-succinate-potentiates-brain-metabolism-in-head-injury-patients
#4
Ibrahim Jalloh, Adel Helmy, Duncan J Howe, Richard J Shannon, Peter Grice, Andrew Mason, Clare N Gallagher, Matthew G Stovell, Susan van der Heide, Michael P Murphy, John D Pickard, David K Menon, T Adrian Carpenter, Peter J Hutchinson, Keri Lh Carpenter
Following traumatic brain injury, complex cerebral energy perturbations occur. Correlating with unfavourable outcome, high brain extracellular lactate/pyruvate ratio suggests hypoxic metabolism and/or mitochondrial dysfunction. We investigated whether focal administration of succinate, a tricarboxylic acid cycle intermediate interacting directly with the mitochondrial electron transport chain, could improve cerebral metabolism. Microdialysis perfused disodium 2,3-(13)C2 succinate (12 mmol/L) for 24 h into nine sedated traumatic brain injury patients' brains, with simultaneous microdialysate collection for ISCUS analysis of energy metabolism biomarkers (nine patients) and nuclear magnetic resonance of (13)C-labelled metabolites (six patients)...
October 17, 2016: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27783456/improving-the-performance-of-formamidinium-and-cesium-lead-triiodide-perovskite-solar-cells-using-lead-thiocyanate-additives
#5
Yue Yu, Changlei Wang, Corey R Grice, Niraj Shrestha, Jing Chen, Dewei Zhao, Weiqiang Liao, Alexander J Cimaroli, Paul J Roland, Randy J Ellingson, Yanfa Yan
Formamidinium lead triiodide (FAPbI3 ) is considered as an alternative to methylammonium lead triiodide (MAPbI3 ) because of its lower band gap and better thermal stability. However, owing to the large size of FA cations, it is difficult to synthesize high-quality FAPbI3 thin films without the formation of an undesirable yellow phase. Smaller sized cations, such as MA and Cs, have been successfully used to suppress the formation of the yellow phase. Whereas FA and MA lead triiodide perovskite solar cells (PVSCs) have achieved power conversion efficiencies (PCEs) higher than 20 %, the PCEs of formamidinium and cesium lead triiodide (FA1-x Csx PbI3 ) PVSCs have been only approximately 16...
October 26, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27712950/health-disparities-and-the-microbiome
#6
Keisha Findley, David R Williams, Elizabeth A Grice, Vence L Bonham
An individual's microbiome is likely to be an important contributor to certain health disparity diseases and conditions. We present a framework to study the role of the microbiome and the multiple factors that are likely to influence differences in disease predisposition, onset, and progression at the individual and population level.
November 2016: Trends in Microbiology
https://www.readbyqxmd.com/read/27706155/alignerboost-a-generalized-software-toolkit-for-boosting-next-gen-sequencing-mapping-accuracy-using-a-bayesian-based-mapping-quality-framework
#7
Qi Zheng, Elizabeth A Grice
Accurate mapping of next-generation sequencing (NGS) reads to reference genomes is crucial for almost all NGS applications and downstream analyses. Various repetitive elements in human and other higher eukaryotic genomes contribute in large part to ambiguously (non-uniquely) mapped reads. Most available NGS aligners attempt to address this by either removing all non-uniquely mapping reads, or reporting one random or "best" hit based on simple heuristics. Accurate estimation of the mapping quality of NGS reads is therefore critical albeit completely lacking at present...
October 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27686333/tapping-the-archives-the-sterol-composition-of-marine-sponge-species-as-determined-non-invasively-from-museum-preserved-specimens-reveals-biogeographical-features
#8
S K Lengger, J Fromont, K Grice
Over 8600 species are currently recorded in the phylum Porifera (sponges). They produce a large diversity of biochemical compounds including sterols, with more than 250 different sterols identified. Some of these sterols are of great interest, due to their use for fingerprinting in ecological and biomarker (molecular fossil) studies. As a large number of identified extant species from biodiversity surveys are housed in museum collections, preserved in ethanol, these present a potentially rich source of identified specimens for comparative lipid analyses...
September 29, 2016: Geobiology
https://www.readbyqxmd.com/read/27683348/does-sports-participation-including-level-of-performance-and-previous-injury-increase-risk-of-osteoarthritis-a-systematic-review-and-meta-analysis
#9
Gui Tran, Toby O Smith, Adam Grice, Sarah R Kingsbury, Paul McCrory, Philip G Conaghan
BACKGROUND: To assess the relationship between sport and osteoarthritis (OA), and specifically to determine whether previous participation, in terms of level (elite or non-elite), type of sport, intensity or previous injury, was associated with OA. METHODS: This systematic review was developed using PRISMA guidelines. Databases were searched (to May 2016). Narrative review and meta-analysis (with risk ratio (RR) and 95% CIs) approaches were undertaken where appropriate...
September 28, 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27672014/efficacy-of-foot-and-ankle-corticosteroid-injections
#10
John Grice, Daniel Marsland, George Smith, James Calder
BACKGROUND: Corticosteroid injections have been used for a variety of foot and ankle pathologies over the years, and our aim was to evaluate the efficacy and safety of them in our clinic. MATERIALS AND METHODS: We performed a retrospective review of notes and a telephone questionnaire on the clinical outcome of all patients who underwent a corticosteroid injection of the foot or ankle in a year. All procedures were performed in an outpatient setting by a consultant musculoskeletal radiologist using either ultrasound or X-ray guidance and had a minimum of 2 years of follow-up...
September 25, 2016: Foot & Ankle International
https://www.readbyqxmd.com/read/27651462/a-small-stem-loop-structure-of-the-ebola-virus-trailer-is-essential-for-replication-and-interacts-with-heat-shock-protein-a8
#11
Joanna Sztuba-Solinska, Larissa Diaz, Mia R Kumar, Gaëlle Kolb, Michael R Wiley, Lucas Jozwick, Jens H Kuhn, Gustavo Palacios, Sheli R Radoshitzky, Stuart F J Le Grice, Reed F Johnson
Ebola virus (EBOV) is a single-stranded negative-sense RNA virus belonging to the Filoviridae family. The leader and trailer non-coding regions of the EBOV genome likely regulate its transcription, replication, and progeny genome packaging. We investigated the cis-acting RNA signals involved in RNA-RNA and RNA-protein interactions that regulate replication of eGFP-encoding EBOV minigenomic RNA and identified heat shock cognate protein family A (HSC70) member 8 (HSPA8) as an EBOV trailer-interacting host protein...
November 16, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27634383/mechanistic-evaluation-of-hydration-effects-on-the-human-epidermal-permeation-of-salicylate-esters
#12
Shereen Yousef, Yousuf Mohammed, Sarika Namjoshi, Jeffrey Grice, Wedad Sakran, Michael Roberts
We sought to understand when and how hydration enhances the percutaneous absorption of salicylate esters. Human epidermal membrane fluxes and stratum corneum solubilities of neat and diluted solutions of three esters were determined under hydrated and dehydrated conditions. Hydration doubled the human epidermal flux seen for methyl and ethyl salicylate under dehydrated conditions and increased the flux of neat glycol salicylate 10-fold. Mechanistic analyses showed that this hydration-induced enhancement arises mainly from an increase in the stratum corneum diffusivity of the three esters...
September 15, 2016: AAPS Journal
https://www.readbyqxmd.com/read/27624531/permeation-of-topically-applied-magnesium-ions-through-human-skin-is-facilitated-by-hair-follicles
#13
Navin Chandrakanth Chandrasekaran, Washington Y Sanchez, Yousuf H Mohammed, Jeffrey E Grice, Michael S Roberts, Ross T Barnard
Magnesium is an important micronutrient essential for various biological processes and its deficiency has been linked to several inflammatory disorders in humans. Topical magnesium delivery is one of the oldest forms of therapy for skin diseases, for example Dead Sea therapy and Epsom salt baths. Some anecdotal evidence and a few published reports have attributed amelioration of inflammatory skin conditions to the topical application of magnesium. On the other hand, transport of magnesium ions across the protective barrier of skin, the stratum corneum, is contentious...
June 1, 2016: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
https://www.readbyqxmd.com/read/27622903/fabrication-of-efficient-low-bandgap-perovskite-solar-cells-by-combining-formamidinium-tin-iodide-with-methylammonium-lead-iodide
#14
Weiqiang Liao, Dewei Zhao, Yue Yu, Niraj Shrestha, Kiran Ghimire, Corey R Grice, Changlei Wang, Yuqing Xiao, Alexander J Cimaroli, Randy J Ellingson, Nikolas J Podraza, Kai Zhu, Ren-Gen Xiong, Yanfa Yan
Mixed tin (Sn)-lead (Pb) perovskites with high Sn content exhibit low bandgaps suitable for fabricating the bottom cell of perovskite-based tandem solar cells. In this work, we report on the fabrication of efficient mixed Sn-Pb perovskite solar cells using precursors combining formamidinium tin iodide (FASnI3) and methylammonium lead iodide (MAPbI3). The best-performing cell fabricated using a (FASnI3)0.6(MAPbI3)0.4 absorber with an absorption edge of ∼1.2 eV achieved a power conversion efficiency (PCE) of 15...
September 28, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27601572/redefining-the-chronic-wound-microbiome-fungal-communities-are-prevalent-dynamic-and-associated-with-delayed-healing
#15
Lindsay Kalan, Michael Loesche, Brendan P Hodkinson, Kristopher Heilmann, Gordon Ruthel, Sue E Gardner, Elizabeth A Grice
UNLABELLED: Chronic nonhealing wounds have been heralded as a silent epidemic, causing significant morbidity and mortality especially in elderly, diabetic, and obese populations. Polymicrobial biofilms in the wound bed are hypothesized to disrupt the highly coordinated and sequential events of cutaneous healing. Both culture-dependent and -independent studies of the chronic-wound microbiome have almost exclusively focused on bacteria, omitting what we hypothesize are important fungal contributions to impaired healing and the development of complications...
September 6, 2016: MBio
https://www.readbyqxmd.com/read/27571446/lead-free-inverted-planar-formamidinium-tin-triiodide-perovskite-solar-cells-achieving-power-conversion-efficiencies-up-to-6-22
#16
Weiqiang Liao, Dewei Zhao, Yue Yu, Corey R Grice, Changlei Wang, Alexander J Cimaroli, Philip Schulz, Weiwei Meng, Kai Zhu, Ren-Gen Xiong, Yanfa Yan
Efficient lead (Pb)-free inverted planar formamidinium tin triiodide (FASnI3 ) perovskite solar cells (PVSCs) are demonstrated. Our FASnI3 PVSCs achieved average power conversion efficiencies (PCEs) of 5.41% ± 0.46% and a maximum PCE of 6.22% under forward voltage scan. The PVSCs exhibit small photocurrent-voltage hysteresis and high reproducibility. The champion cell shows a steady-state efficiency of ≈6.00% for over 100 s.
November 2016: Advanced Materials
https://www.readbyqxmd.com/read/27566400/temporal-stability-in-chronic-wound-microbiota-is-associated-with-poor-healing
#17
Michael Loesche, Sue E Gardner, Lindsay Kalan, Joseph Horwinski, Qi Zheng, Brendan P Hodkinson, Amanda S Tyldsley, Carrie L Franciscus, Stephen L Hillis, Samir Mehta, David J Margolis, Elizabeth A Grice
Microbial burden of chronic wounds is believed to play an important role in impaired healing and the development of infection-related complications. However, clinical cultures have little predictive value of wound outcomes, and culture-independent studies have been limited by cross-sectional design and small cohort size. We systematically evaluated the temporal dynamics of the microbiota colonizing diabetic foot ulcers, a common and costly complication of diabetes, and its association with healing and clinical complications...
August 24, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27566133/hydrogen-isotopic-differences-between-c3-and-c4-land-plant-lipids-consequences-of-compartmentation-in-c4-photosynthetic-chemistry-and-c3-photorespiration
#18
Youping Zhou, Kliti Grice, Hilary Stuart-Williams, Charles H Hocart, Arthur Gessler, Graham D Farquhar
The (2) H/(1) H ratio of carbon-bound H in biolipids holds potential for probing plant lipid biosynthesis and metabolism. The biochemical mechanism underlying the isotopic differences between lipids from C3 and C4 plants is still poorly understood. GC-pyrolysis-IRMS (gas chromatography-pyrolysis-isotope ratio mass spectrometry) measurement of the (2) H/(1) H ratio of leaf lipids from controlled and field grown plants indicates that the biochemical isotopic fractionation (ε(2) Hlipid_biochem ) differed between C3 and C4 plants in a pathway-dependent manner: ε(2) HC4  > ε(2) HC3 for the acetogenic pathway, ε(2) HC4  < ε(2) HC3 for the mevalonic acid pathway and the 1-deoxy-D-xylulose 5-phosphate pathway across all species examined...
August 27, 2016: Plant, Cell & Environment
https://www.readbyqxmd.com/read/27566119/prenatal-maternal-smoking-and-increased-risk-for-tourette-syndrome-and-chronic-tic-disorders
#19
Heidi A Browne, Amirhossein Modabbernia, Joseph D Buxbaum, Stefan N Hansen, Diana E Schendel, Erik T Parner, Abraham Reichenberg, Dorothy E Grice
OBJECTIVE: We assessed the role of prenatal maternal smoking in risk for Tourette syndrome and chronic tic disorder (TS/CT) and pediatric-onset obsessive-compulsive disorder (OCD). METHOD: In an analysis of 73,073 singleton pregnancies from the Danish National Birth Cohort, we calculated incidence rates (IR) per 1,000 person-year for TS/CT and OCD. We then determined crude and adjusted hazard ratios and 95% CIs associated with prenatal maternal smoking, considering smoking as a dichotomous (yes/no) variable or a stratified variable (no smoking, light smoking, and heavy smoking [≥10 cigarettes/day])...
September 2016: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27494079/pre-and-perinatal-complications-in-relation-to-tourette-syndrome-and-co-occurring-obsessive-compulsive-disorder-and-attention-deficit-hyperactivity-disorder
#20
Mohamed Abdulkadir, Jay A Tischfield, Robert A King, Thomas V Fernandez, Lawrence W Brown, Keun-Ah Cheon, Barbara J Coffey, Sebastian F T M de Bruijn, Lonneke Elzerman, Blanca Garcia-Delgar, Donald L Gilbert, Dorothy E Grice, Julie Hagstrøm, Tammy Hedderly, Isobel Heyman, Hyun Ju Hong, Chaim Huyser, Laura Ibanez-Gomez, Young Key Kim, Young-Shin Kim, Yun-Joo Koh, Sodahm Kook, Samuel Kuperman, Andreas Lamerz, Bennett Leventhal, Andrea G Ludolph, Marcos Madruga-Garrido, Athanasios Maras, Marieke D Messchendorp, Pablo Mir, Astrid Morer, Alexander Münchau, Tara L Murphy, Thaïra J C Openneer, Kerstin J Plessen, Judith J G Rath, Veit Roessner, Odette Fründt, Eun-Young Shin, Deborah A Sival, Dong-Ho Song, Jungeun Song, Anne-Marie Stolte, Jennifer Tübing, Els van den Ban, Frank Visscher, Sina Wanderer, Martin Woods, Samuel H Zinner, Matthew W State, Gary A Heiman, Pieter J Hoekstra, Andrea Dietrich
Pre- and perinatal complications have been implicated in the onset and clinical expression of Tourette syndrome albeit with considerable inconsistencies across studies. Also, little is known about their role in co-occurring obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD) in individuals with a tic disorder. Therefore, we aimed to investigate the role of pre- and perinatal complications in relation to the presence and symptom severity of chronic tic disorder and co-occurring OCD and ADHD using data of 1113 participants from the Tourette International Collaborative Genetics study...
November 2016: Journal of Psychiatric Research
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