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https://www.readbyqxmd.com/read/28720042/exotic-dancing-and-relationship-violence-exploring-indigeneity-gender-and-agency
#1
Jade Le Grice
How should we begin to explore the complex considerations influencing young Indigenous New Zealand Māori women's sexuality? Centring a Māori woman's analysis through a Mana Wāhine methodology, and utilising an Indigenous form of storying, pūrākau, I explore this question by attending to my autobiographical memory of experiences of exotic dancing and moments of violence in heterosexual relationships. The analysis provides critical reflection on the interchanges between individual experience and the social and cultural conditions of a reality, informed by colonisation and historical trauma...
July 19, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/28669672/cutaneous-leishmaniasis-induces-a-transmissible-dysbiotic-skin-microbiota-that-promotes-skin-inflammation
#2
Ciara Gimblet, Jacquelyn S Meisel, Michael A Loesche, Stephen D Cole, Joseph Horwinski, Fernanda O Novais, Ana M Misic, Charles W Bradley, Daniel P Beiting, Shelley C Rankin, Lucas P Carvalho, Edgar M Carvalho, Phillip Scott, Elizabeth A Grice
Skin microbiota can impact allergic and autoimmune responses, wound healing, and anti-microbial defense. We investigated the role of skin microbiota in cutaneous leishmaniasis and found that human patients infected with Leishmania braziliensis develop dysbiotic skin microbiota, characterized by increases in the abundance of Staphylococcus and/or Streptococcus. Mice infected with L. major exhibit similar changes depending upon disease severity. Importantly, this dysbiosis is not limited to the lesion site, but is transmissible to normal skin distant from the infection site and to skin from co-housed naive mice...
June 22, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28630195/topical-antimicrobial-treatments-can-elicit-shifts-to-resident-skin-bacterial-communities-and-reduce-colonization-by-staphylococcus-aureus-competitors
#3
Adam J SanMiguel, Jacquelyn S Meisel, Joseph Horwinski, Qi Zheng, Elizabeth A Grice
The skin microbiome is a complex ecosystem with important implications for cutaneous health and disease. Topical antibiotics and antiseptics are often employed to preserve the balance of this population, and inhibit colonization by more pathogenic bacteria. Despite their widespread use, however, the impact of these interventions on broader microbial communities remains poorly understood. Here we report the longitudinal effects of topical antibiotics and antiseptics on skin bacterial communities and their role in Staphylococcus aureus colonization resistance...
June 19, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28625133/recent-advances-in-targeting-the-hiv-1-tat-tar-complex
#4
Fardokht A Abulwerdi, Stuart F J Le Grice
Following seminal discoveries by Rosen and co-workers in 1985, the HIV-1 TAR has emerged as one of the most extensively studied regulatory elements of the HIV-1 genome. Located adjacent to the long terminal repeat promoter, this cis-acting motif, in conjunction with the viral Tat protein, plays a critical role in viral genomic RNA synthesis via modification of the transcription complex. As such, the Tat/TAR axis has been the subject of intense efforts aimed at developing therapeutic interventions, directed against both the protein and nucleic acid components...
June 15, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28555406/investigation-of-previously-implicated-genetic-variants-in-chronic-tic-disorders-a-transmission-disequilibrium-test-approach
#5
Mohamed Abdulkadir, Douglas Londono, Derek Gordon, Thomas V Fernandez, Lawrence W Brown, Keun-Ah Cheon, Barbara J Coffey, Lonneke Elzerman, Carolin Fremer, Odette Fründt, Blanca Garcia-Delgar, Donald L Gilbert, Dorothy E Grice, Tammy Hedderly, Isobel Heyman, Hyun Ju Hong, Chaim Huyser, Laura Ibanez-Gomez, Ewgeni Jakubovski, Young Key Kim, Young Shin Kim, Yun-Joo Koh, Sodahm Kook, Samuel Kuperman, Bennett Leventhal, Andrea G Ludolph, Marcos Madruga-Garrido, Athanasios Maras, Pablo Mir, Astrid Morer, Kirsten Müller-Vahl, Alexander Münchau, Tara L Murphy, Kerstin J Plessen, Veit Roessner, Eun-Young Shin, Dong-Ho Song, Jungeun Song, Jennifer Tübing, Els van den Ban, Frank Visscher, Sina Wanderer, Martin Woods, Samuel H Zinner, Robert A King, Jay A Tischfield, Gary A Heiman, Pieter J Hoekstra, Andrea Dietrich
Genetic studies in Tourette syndrome (TS) are characterized by scattered and poorly replicated findings. We aimed to replicate findings from candidate gene and genome-wide association studies (GWAS). Our cohort included 465 probands with chronic tic disorder (93% TS) and both parents from 412 families (some probands were siblings). We assessed 75 single nucleotide polymorphisms (SNPs) in 465 parent-child trios; 117 additional SNPs in 211 trios; and 4 additional SNPs in 254 trios. We performed SNP and gene-based transmission disequilibrium tests and compared nominally significant SNP results with those from a large independent case-control cohort...
May 29, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28492509/transcriptomic-profiling-of-the-allorecognition-response-to-grafting-in-the-demosponge-amphimedon-queenslandica
#6
Laura F Grice, Bernard M Degnan
Sponges, despite their simple body plan, discriminate between self and nonself with remarkable specificity. Sponge grafting experiments simulate the effects of natural self or nonself contact under laboratory conditions. Here we take a transcriptomic approach to investigate the temporal response to self and nonself grafts in the marine demosponge Amphimedon queenslandica. Auto- and allografts were established, observed and sampled over a period of three days, over which time the grafts either rejected or accepted, depending on the identity of the paired individuals, in a replicable and predictable manner...
May 11, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28479978/convergent-minds-ostension-inference-and-grice-s-third-clause
#7
Richard Moore
A prevailing view is that while human communication has an 'ostensive-inferential' or 'Gricean' intentional structure, animal communication does not. This would make the psychological states that support human and animal forms of communication fundamentally different. Against this view, I argue that there are grounds to expect ostensive communication in non-human clades. This is because it is sufficient for ostensive communication that one intentionally addresses one's utterance to one's intended interlocutor-something that is both a functional pre-requisite of successful communication and cognitively undemanding...
June 6, 2017: Interface Focus
https://www.readbyqxmd.com/read/28438788/associations-between-persistent-organic-pollutants-type-2-diabetes-diabetic-nephropathy-and-mortality
#8
Brian A Grice, Robert G Nelson, Desmond E Williams, William C Knowler, Clinton Mason, Robert L Hanson, Kai McKeever Bullard, Meda E Pavkov
OBJECTIVE: Relationships were examined between persistent organic pollutants (POPs) and incident type 2 diabetes, end-stage renal disease (ESRD) and mortality. METHODS: In a nested case-control study, 300 persons without diabetes had baseline examinations between 1969 and 1974; 149 developed diabetes (cases) and 151 remained non-diabetic (controls) during 8.0 and 23.1 years of follow-up, respectively. POPs were measured at baseline. ORs for diabetes were computed by logistic regression analysis...
April 24, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28386571/the-broken-ring-of-fire-a-new-radiological-sign-as-predictor-of-syndesmosis-injury
#9
James Calder, Adam Mitchell, Adam Lomax, Moez S Ballal, John Grice, Niek van Dijk, Justin Lee
BACKGROUND: Subcircumferential periosteal edema above the ankle joint is frequently present on magnetic resonance imaging (MRI) with syndesmosis injuries but has not been previously reported. Fluid height within the interosseous membrane also has not previously been shown to be associated with syndesmosis injury severity. PURPOSE: To investigate whether a new sign on MRI and measurement of the length of fluid within the interosseous membrane above the ankle may be used to enable identification of a syndesmosis injury and allow differentiation from lateral ligament injury...
March 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28383682/kaposi-s-sarcoma-associated-herpesvirus-polyadenylated-nuclear-rna-a-structural-scaffold-for-nuclear-cytoplasmic-and-viral-proteins
#10
Joanna Sztuba-Solinska, Jason W Rausch, Rodman Smith, Jennifer T Miller, Denise Whitby, Stuart F J Le Grice
Kaposi's sarcoma-associated herpes virus (KSHV) polyadenylated nuclear (PAN) RNA facilitates lytic infection, modulating the cellular immune response by interacting with viral and cellular proteins and DNA. Although a number nucleoprotein interactions involving PAN have been implicated, our understanding of binding partners and PAN RNA binding motifs remains incomplete. Herein, we used SHAPE-mutational profiling (SHAPE-MaP) to probe PAN in its nuclear, cytoplasmic or viral environments or following cell/virion lysis and removal of proteins...
April 5, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28368977/cutaneous-burn-injury-promotes-shifts-in-the-bacterial-microbiome-in-autologous-donor-skin-implications-for-skin-grafting-outcomes
#11
Jennifer K Plichta, Xiang Gao, Huaiying Lin, Qunfeng Dong, Evelyn Toh, David E Nelson, Richard L Gamelli, Elizabeth A Grice, Katherine A Radek
INTRODUCTION: The cutaneous microbiome maintains skin barrier function, regulates inflammation, and stimulates wound healing responses. Burn injury promotes an excessive activation of the cutaneous and systemic immune response directed against commensal and invading pathogens. Skin grafting is the primary method of reconstructing full-thickness burns, and wound infection continues to be a significant complication. METHODS: In this study, the cutaneous bacterial microbiome was evaluated and subsequently compared to patient outcomes...
March 31, 2017: Shock
https://www.readbyqxmd.com/read/28349199/amyloid-%C3%AE-accumulation-in-the-cns-in-human-growth-hormone-recipients-in-the-uk
#12
Diane L Ritchie, Peter Adlard, Alexander H Peden, Suzanne Lowrie, Margaret Le Grice, Kimberley Burns, Rosemary J Jackson, Helen Yull, Michael J Keogh, Wei Wei, Patrick F Chinnery, Mark W Head, James W Ironside
Human-to-human transmission of Creutzfeldt-Jakob disease (CJD) has occurred through medical procedures resulting in iatrogenic CJD (iCJD). One of the commonest causes of iCJD was the use of human pituitary-derived growth hormone (hGH) to treat primary or secondary growth hormone deficiency. As part of a comprehensive tissue-based analysis of the largest cohort yet collected (35 cases) of UK hGH-iCJD cases, we describe the clinicopathological phenotype of hGH-iCJD in the UK. In the 33/35 hGH-iCJD cases with sufficient paraffin-embedded tissue for full pathological examination, we report the accumulation of the amyloid beta (Aβ) protein associated with Alzheimer's disease (AD) in the brains and cerebral blood vessels in 18/33 hGH-iCJD patients and for the first time in 5/12 hGH recipients who died from causes other than CJD...
March 27, 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28296633/the-vacuolar-atpase-complex-and-assembly-factors-tmem199-and-ccdc115-control-hif1%C3%AE-prolyl-hydroxylation-by-regulating-cellular-iron-levels
#13
Anna L Miles, Stephen P Burr, Guinevere L Grice, James A Nathan
Hypoxia Inducible transcription Factors (HIFs) are principally regulated by the 2-oxoglutarate and Iron(II) prolyl hydroxylase (PHD) enzymes, which hydroxylate the HIFα subunit, facilitating its proteasome-mediated degradation. Observations that HIFα hydroxylation can be impaired even when oxygen is sufficient emphasise the importance of understanding the complex nature of PHD regulation. Here, we use an unbiased genome-wide genetic screen in near-haploid human cells to uncover cellular processes that regulate HIF1α...
March 15, 2017: ELife
https://www.readbyqxmd.com/read/28294975/reverse-transcription-in-the-saccharomyces-cerevisiae-long-terminal-repeat-retrotransposon-ty3
#14
REVIEW
Jason W Rausch, Jennifer T Miller, Stuart F J Le Grice
Converting the single-stranded retroviral RNA into integration-competent double-stranded DNA is achieved through a multi-step process mediated by the virus-coded reverse transcriptase (RT). With the exception that it is restricted to an intracellular life cycle, replication of the Saccharomyces cerevisiae long terminal repeat (LTR)-retrotransposon Ty3 genome is guided by equivalent events that, while generally similar, show many unique and subtle differences relative to the retroviral counterparts. Until only recently, our knowledge of RT structure and function was guided by a vast body of literature on the human immunodeficiency virus (HIV) enzyme...
March 15, 2017: Viruses
https://www.readbyqxmd.com/read/28277679/electrochemical-reduction-of-co2-catalyzed-by-re-pyridine-oxazoline-co-3cl-complexes
#15
John K Nganga, Christian R Samanamu, Joseph M Tanski, Carlos Pacheco, Cesar Saucedo, Victor S Batista, Kyle A Grice, Mehmed Z Ertem, Alfredo M Angeles-Boza
A series of rhenium tricarbonyl complexes coordinated by asymmetric diimine ligands containing a pyridine moiety bound to an oxazoline ring were synthesized, structurally and electrochemically characterized, and screened for CO2 reduction ability. The reported complexes are of the type Re(N-N)(CO)3Cl, with N-N = 2-(pyridin-2-yl)-4,5-dihydrooxazole (1), 5-methyl-2-(pyridin-2-yl)-4,5-dihydrooxazole (2), and 5-phenyl-2-(pyridin-2-yl)-4,5-dihydrooxazole (3). The electrocatalytic reduction of CO2 by these complexes was observed in a variety of solvents and proceeds more quickly in acetonitrile than in dimethylformamide (DMF) and dimethyl sulfoxide (DMSO)...
March 9, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28211841/predictors-of-employment-status-among-adults-with-autism-spectrum-disorder
#16
Alisha Ohl, Mira Grice Sheff, Sarah Little, Jamie Nguyen, Kelly Paskor, Aliza Zanjirian
BACKGROUND: In the United States, adults with Autism Spectrum Disorder (ASD) experience high rates of unemployment and underemployment in relation to adults with other disabilities and the general population. Yet there is little research examining their employment experiences and the predictors of employment status. OBJECTIVE: The purpose of this study was to examine the employment characteristics and histories of both employed and unemployed adults with ASD, and the factors that contributed to their employment status...
February 17, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28201872/online-quantification-of-criegee-intermediates-of-%C3%AE-pinene-ozonolysis-by-stabilization-with-spin-traps-and-proton-transfer-reaction-mass-spectrometry-detection
#17
Chiara Giorio, Steven J Campbell, Maurizio Bruschi, Francesco Tampieri, Antonio Barbon, Antonio Toffoletti, Andrea Tapparo, Claudia Paijens, Andrew J Wedlake, Peter Grice, Duncan J Howe, Markus Kalberer
Biogenic alkenes, which are among the most abundant volatile organic compounds in the atmosphere, are readily oxidized by ozone. Characterizing the reactivity and kinetics of the first-generation products of these reactions, carbonyl oxides (often named Criegee intermediates), is essential in defining the oxidation pathways of organic compounds in the atmosphere but is highly challenging due to the short lifetime of these zwitterions. Here, we report the development of a novel online method to quantify atmospherically relevant Criegee intermediates (CIs) in the gas phase by stabilization with spin traps and analysis with proton-transfer reaction mass spectrometry...
March 7, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28194314/evolutionary-and-functional-implications-of-hypervariable-loci-within-the-skin-virome
#18
Geoffrey D Hannigan, Qi Zheng, Jacquelyn S Meisel, Samuel S Minot, Frederick D Bushman, Elizabeth A Grice
Localized genomic variability is crucial for the ongoing conflicts between infectious microbes and their hosts. An understanding of evolutionary and adaptive patterns associated with genomic variability will help guide development of vaccines and antimicrobial agents. While most analyses of the human microbiome have focused on taxonomic classification and gene annotation, we investigated genomic variation of skin-associated viral communities. We evaluated patterns of viral genomic variation across 16 healthy human volunteers...
2017: PeerJ
https://www.readbyqxmd.com/read/28194120/sincere-deceitful-and-ironic-communicative-acts-and-the-role-of-the-theory-of-mind-in-childhood
#19
Francesca M Bosco, Ilaria Gabbatore
The aim of the study is to investigate the relationship among age, first- and second-order Theory of Mind and the increasing ability of children to understand and produce different kinds of communicative acts - sincere, ironic, and deceitful communicative acts - expressed through linguistic and extralinguistic expressive means. To communicate means to modify an interlocutor's mental states (Grice, 1989), and pragmatics studies the inferential processes that are necessary to fill the gap, which often exists in human communication, between the literal meaning of a speaker's utterance and what the speaker intends to communicate to the interlocutor...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28190633/novel-5-arylthio-5h-chromenopyridines-as-a-new-class-of-anti-fibrotic-agents
#20
Renukadevi Patil, Anandita Ghosh, Phoebus Sun Cao, Roger D Sommer, Kyle A Grice, Gulam Waris, Shivaputra Patil
Liver fibrosis is a critical wound healing response to chronic liver injury such as hepatitis C virus (HCV) infection. If persistent, liver fibrosis can lead to cirrhosis and hepatocellular carcinoma (HCC). The development of new therapies for preventing liver fibrosis and its progression to cancer associated with HCV infection remains a critical challenge. Identification of novel anti-fibrotic compounds will provide opportunities for innovative therapeutic intervention of HCV-mediated liver fibrosis. We designed and synthesized a focused set of 5-arylthio-5H-chromenopyridines as a new class of anti-fibrotic agents...
February 1, 2017: Bioorganic & Medicinal Chemistry Letters
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