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https://www.readbyqxmd.com/read/28211841/predictors-of-employment-status-among-adults-with-autism-spectrum-disorder
#1
Alisha Ohl, Mira Grice Sheff, Sarah Little, Jamie Nguyen, Kelly Paskor, Aliza Zanjirian
BACKGROUND: In the United States, adults with Autism Spectrum Disorder (ASD) experience high rates of unemployment and underemployment in relation to adults with other disabilities and the general population. Yet there is little research examining their employment experiences and the predictors of employment status. OBJECTIVE: The purpose of this study was to examine the employment characteristics and histories of both employed and unemployed adults with ASD, and the factors that contributed to their employment status...
February 17, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28201872/online-quantification-of-criegee-intermediates-of-%C3%AE-pinene-ozonolysis-by-stabilisation-with-spin-traps-and-proton-transfer-reaction-mass-spectrometry-detection
#2
Chiara Giorio, Steven J Campbell, Maurizio Bruschi, Francesco Tampieri, Antonio Barbon, Antonio Toffoletti, Andrea Tapparo, Claudia Paijens, Andrew J Wedlake, Peter Grice, Duncan J Howe, Markus Kalberer
Biogenic alkenes, which are among the most abundant volatile organic compounds in the atmosphere, are readily oxidised by ozone. Characterising the reactivity and kinetics of the first generation products of these reactions, carbonyl oxides (often named Criegee intermediates), is essential in defining the oxidation pathways of organic compounds in the atmosphere but is highly challenging due to the short lifetime of these zwitterions. Here, we report the development of a novel online method to quantify atmospherically relevant Criegee intermediates (CIs) in the gas phase by stabilisation with spin traps and analysis with proton transfer reaction mass spectrometry...
February 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28194314/evolutionary-and-functional-implications-of-hypervariable-loci-within-the-skin-virome
#3
Geoffrey D Hannigan, Qi Zheng, Jacquelyn S Meisel, Samuel S Minot, Frederick D Bushman, Elizabeth A Grice
Localized genomic variability is crucial for the ongoing conflicts between infectious microbes and their hosts. An understanding of evolutionary and adaptive patterns associated with genomic variability will help guide development of vaccines and antimicrobial agents. While most analyses of the human microbiome have focused on taxonomic classification and gene annotation, we investigated genomic variation of skin-associated viral communities. We evaluated patterns of viral genomic variation across 16 healthy human volunteers...
2017: PeerJ
https://www.readbyqxmd.com/read/28194120/sincere-deceitful-and-ironic-communicative-acts-and-the-role-of-the-theory-of-mind-in-childhood
#4
Francesca M Bosco, Ilaria Gabbatore
The aim of the study is to investigate the relationship among age, first- and second-order Theory of Mind and the increasing ability of children to understand and produce different kinds of communicative acts - sincere, ironic, and deceitful communicative acts - expressed through linguistic and extralinguistic expressive means. To communicate means to modify an interlocutor's mental states (Grice, 1989), and pragmatics studies the inferential processes that are necessary to fill the gap, which often exists in human communication, between the literal meaning of a speaker's utterance and what the speaker intends to communicate to the interlocutor...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28190633/novel-5-arylthio-5h-chromenopyridines-as-a-new-class-of-anti-fibrotic-agents
#5
Renukadevi Patil, Anandita Ghosh, Phoebus Sun Cao, Roger D Sommer, Kyle A Grice, Gulam Waris, Shivaputra Patil
Liver fibrosis is a critical wound healing response to chronic liver injury such as hepatitis C virus (HCV) infection. If persistent, liver fibrosis can lead to cirrhosis and hepatocellular carcinoma (HCC). The development of new therapies for preventing liver fibrosis and its progression to cancer associated with HCV infection remains a critical challenge. Identification of novel anti-fibrotic compounds will provide opportunities for innovative therapeutic intervention of HCV-mediated liver fibrosis. We designed and synthesized a focused set of 5-arylthio-5H-chromenopyridines as a new class of anti-fibrotic agents...
February 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28168677/examining-the-efficacy-of-a-family-peer-advocate-model-for-black-and-hispanic-caregivers-of-children-with-autism-spectrum-disorder
#6
J M Jamison, E Fourie, P M Siper, M P Trelles, Julia George-Jones, A Buxbaum Grice, J Krata, E Holl, J Shaoul, B Hernandez, L Mitchell, M M McKay, J D Buxbaum, Alexander Kolevzon
Autism spectrum disorder (ASD) affects individuals across all racial and ethnic groups, yet rates of diagnosis are disproportionately higher for Black and Hispanic children. Caregivers of children with ASD experience significant stressors, which have been associated with parental strain, inadequate utilization of mental health services and lower quality of life. The family peer advocate (FPA) model has been utilized across service delivery systems to provide family-to-family support, facilitate engagement, and increase access to care...
February 6, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28160355/the-effect-of-uni-and-bilateral-thalamic-deep-brain-stimulation-on-speech-in-patients-with-essential-tremor-acoustics-and-intelligibility
#7
Johannes Becker, Michael T Barbe, Mariam Hartinger, Till A Dembek, Jil Pochmann, Jochen Wirths, Niels Allert, Doris Mücke, Anne Hermes, Ingo G Meister, Veerle Visser-Vandewalle, Martine Grice, Lars Timmermann
BACKGROUND: Deep brain stimulation (DBS) of the ventral intermediate nucleus (VIM) is performed to suppress medically-resistant essential tremor (ET). However, stimulation induced dysarthria (SID) is a common side effect, limiting the extent to which tremor can be suppressed. To date, the exact pathogenesis of SID in VIM-DBS treated ET patients is unknown. OBJECTIVE: We investigate the effect of inactivated, uni- and bilateral VIM-DBS on speech production in patients with ET...
February 3, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28104746/origin-and-evolution-of-the-sponge-aggregation-factor-gene-family
#8
Laura F Grice, Marie E A Gauthier, Kathrein E Roper, Xavier Fernàndez-Busquets, Sandie M Degnan, Bernard M Degnan
Although discriminating self from nonself is a cardinal animal trait, metazoan allorecognition genes do not appear to be homologous. Here we characterise the Aggregation Factor (AF) gene family, which encodes putative allorecognition factors in the demosponge Amphimedon queenslandica, and trace its evolution across 24 sponge (Porifera) species. The AF locus in Amphimedon is comprised of a cluster of five similar genes that encode Calx-beta and Von Willebrand domains and a newly defined Wreath domain, and are highly polymorphic...
January 19, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28093576/synthetic-%C3%AE-hydroxytropolones-as-inhibitors-of-hiv-reverse-transcriptase-ribonuclease-h-activity
#9
Ryan P Murelli, Michael P D'Erasmo, Danielle R Hirsch, Christine Meck, Takashi Masaoka, Jennifer A Wilson, Baofeng Zhang, Rajat K Pal, Emilio Gallicchio, John A Beutler, Stuart F J Le Grice
HIV Reverse Transcriptase-associated ribonuclease H activity is a promising enzymatic target for drug development that has not been successfully targeted in the clinic. While the α-hydroxytropolone-containing natural products β-thujaplicinol and manicol have emerged as some of the most potent leads described to date, structure-function studies have been limited to the natural products and semi-synthetic derivatives of manicol. Thus, a library of α-hydroxytropolones synthesized through a convenient oxidopyrylium cycloaddition/ring-opening sequence have been tested in in vitro and cell-based assays, and have been analyzed using computational support...
September 1, 2016: MedChemComm
https://www.readbyqxmd.com/read/28090282/traceless-solid-phase-%C3%AE-hydroxytropolone-synthesis
#10
Michael P D'Erasmo, Takashi Masaoka, Jennifer A Wilson, Errol M Hunte, John A Beutler, Stuart F J Le Grice, Ryan P Murelli
α-Hydroxytropolones are established inhibitors of several therapeutically relevant binuclear metalloenzymes, and thus lead drug targets for various human diseases. We have leveraged a recently-disclosed three-component oxidopyrylium cycloaddition in the first solid-phase synthesis of α-hydroxytropolones. We also showed that, while minor impurities exist after cleavage and aqueous wash, the semi-crude products display activity in HIV RT-associated RNaseH enzymatic and cell-based assays consistent with pure molecules made in solution phase...
September 1, 2016: MedChemComm
https://www.readbyqxmd.com/read/28065996/history-of-the-royal-college-of-chiropractic-sports-sciences-canada-the-early-years
#11
John De Finney, Gordon Lawson, David Gryfe, Susan Gillis-Lawson, John P Crawford
In 1978 the Canadian Chiropractic Association recognized the need to establish an organization that would prepare chiropractors to treat athletic injuries and promote these services to sports organizations. Dr. Adrian Grice approached three chiropractors to establish such an organization. The Canadian Chiropractic Sports Academy (CCSA) was established in 1978. This was the start of the chiropractic sports movement which has seen chiropractors playing prominent roles as team doctors to professional and amateur teams and athletes and in the delivery of care at major national and international competitions...
December 2016: Journal of the Canadian Chiropractic Association
https://www.readbyqxmd.com/read/28024914/topical-and-cutaneous-delivery-using-nanosystems
#12
REVIEW
M S Roberts, Y Mohammed, M N Pastore, S Namjoshi, S Yousef, A Alinaghi, I N Haridass, E Abd, V R Leite-Silva, Hae Benson, J E Grice
The goal of topical and cutaneous delivery is to deliver therapeutic and other substances to a desired target site in the skin at appropriate doses to achieve a safe and efficacious outcome. Normally, however, when the stratum corneum is intact and the skin barrier is uncompromised, this is limited to molecules that are relatively lipophilic, small and uncharged, thereby excluding many potentially useful therapeutic peptides, proteins, vaccines, gene fragments or drug-carrying particles. In this review we will describe how nanosystems are being increasingly exploited for topical and cutaneous delivery, particularly for these previously difficult substances...
December 23, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28002966/development-of-small-molecules-with-a-noncanonical-binding-mode-to-hiv-1-trans-activation-response-tar-rna
#13
Fardokht A Abulwerdi, Matthew D Shortridge, Joanna Sztuba-Solinska, Robert Wilson, Stuart F J Le Grice, Gabriele Varani, John S Schneekloth
Small molecules that bind to RNA potently and specifically are relatively rare. The study of molecules that bind to the HIV-1 transactivation response (TAR) hairpin, a cis-acting HIV genomic element, has long been an important model system for the chemistry of targeting RNA. Here we report the synthesis, biochemical, and structural evaluation of a series of molecules that bind to HIV-1 TAR RNA. A promising analogue, 15, retained the TAR binding affinity of the initial hit and displaced a Tat-derived peptide with an IC50 of 40 μM...
December 22, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27998093/cucurbit-7-uril-tetramethylrhodamine-conjugate-for-direct-sensing-and-cellular-imaging
#14
Andrew T Bockus, Lauren C Smith, Amy G Grice, Omar A Ali, Carolyn C Young, William Mobley, Ashley Leek, James L Roberts, Brittany Vinciguerra, Lyle Isaacs, Adam R Urbach
This paper describes the design and synthesis of a conjugate (Q7R) comprising the synthetic host cucurbit[7]uril (Q7) linked to the fluorescent dye tetramethylrhodamine (TMR), and the characterization of its optical and guest-binding properties as well as its cellular uptake. Q7R was synthesized in two steps from monofunctionalized azidobutyl-Q7 and NHS-activated TMR. The fluorescence of Q7R is quenched upon guest binding, and this observable was used to determine equilibrium dissociation constant (Kd) values...
December 21, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27939841/meeting-report-third-summer-school-on-innovative-approaches-for-identification-of-antiviral-agents-iaaass
#15
REVIEW
Stuart F J Le Grice, Joanna Sztuba-Solinska, Elias Maccioni, Katarzyna J Purzycka, Cristina Parolin, Enzo Tramontano
The third Summer School on Innovative Approaches for Identification of Antiviral Agents (IAAASS) was held from September 28th to October 2nd, 2016 at the Sardegna Ricerche Research Park in Santa Margherita di Pula, Sardinia, Italy. The school brought together graduate students and postdoctoral fellows early in their careers with a faculty of internationally recognized experts, to encourage the sharing of knowledge and experience in virology research and drug development in an informal and interactive environment...
December 8, 2016: Antiviral Research
https://www.readbyqxmd.com/read/27938431/high-rates-of-infection-by-blood-parasites-during-the-nestling-phase-in-uk-columbids-with-notes-on-ecological-associations
#16
Jenny C Dunn, Jennifer E Stockdale, Emma L Bradford, Alexandra McCubbin, Antony J Morris, Philip V Grice, Simon J Goodman, Keith C Hamer
Studies of blood parasite infection in nestling birds rarely find a high prevalence of infection. This is likely due to a combination of short nestling periods (limiting the age at which nestlings can be sampled) and long parasite prepatent periods before gametocytes can be detected in peripheral blood. Here we examine rates of blood parasite infection in nestlings from three Columbid species in the UK. We use this system to address two key hypotheses in the epidemiology of avian haemoparasites: first, that nestlings in open nests have a higher prevalence of infection; and second, that nestlings sampled at 14 days old have a higher apparent infection rate than those sampled at 7 days old...
December 12, 2016: Parasitology
https://www.readbyqxmd.com/read/27923927/reply-to-understanding-the-role-of-fungi-in-chronic-wounds
#17
Lindsay Kalan, Sue E Gardner, Elizabeth A Grice
No abstract text is available yet for this article.
December 6, 2016: MBio
https://www.readbyqxmd.com/read/27923773/mitochondrial-protein-lipoylation-and-the-2-oxoglutarate-dehydrogenase-complex-controls-hif1%C3%AE-stability-in-aerobic-conditions
#18
Stephen P Burr, Ana S H Costa, Guinevere L Grice, Richard T Timms, Ian T Lobb, Peter Freisinger, Roger B Dodd, Gordon Dougan, Paul J Lehner, Christian Frezza, James A Nathan
Hypoxia-inducible transcription factors (HIFs) control adaptation to low oxygen environments by activating genes involved in metabolism, angiogenesis, and redox homeostasis. The finding that HIFs are also regulated by small molecule metabolites highlights the need to understand the complexity of their cellular regulation. Here we use a forward genetic screen in near-haploid human cells to identify genes that stabilize HIFs under aerobic conditions. We identify two mitochondrial genes, oxoglutarate dehydrogenase (OGDH) and lipoic acid synthase (LIAS), which when mutated stabilize HIF1α in a non-hydroxylated form...
November 8, 2016: Cell Metabolism
https://www.readbyqxmd.com/read/27915166/-i-can-t-accept-that-feeling-relationships-between-interoceptive-awareness-mindfulness-and-eating-disorder-symptoms-in-females-with-and-at-risk-of-an-eating-disorder
#19
Paul Lattimore, Bethan R Mead, Leanne Irwin, Lorna Grice, Ruth Carson, Peter Malinowski
Mindfulness based therapies (MBTs) for eating disorders show potential benefit for outcomes yet evidence is scarce regarding the mechanisms by which they influence remission from symptoms. One way that mindfulness approaches create positive outcomes is through enhancement of emotion regulation skills. Maladaptive emotion regulation is a key psychological feature of all eating disorders. The aim of the current study was to identify facets of emotion regulation involved in the relationship between mindfulness and maladaptive eating behaviours...
January 2017: Psychiatry Research
https://www.readbyqxmd.com/read/27913306/effect-of-bradykinin-receptor-antagonism-on-ace-inhibitor-associated-angioedema
#20
Brittany T Straka, Claudia E Ramirez, James B Byrd, Elizabeth Stone, Alencia Woodard-Grice, Hui Nian, Chang Yu, Aleena Banerji, Nancy J Brown
BACKGROUND: The B2 receptor antagonist icatibant is approved for treatment of attacks of hereditary angioedema. Icatibant has been reported to decrease time-to-resolution of angiotensin-converting enzyme (ACE) inhibitor-associated angioedema in 1 study of European patients. OBJECTIVE: We sought to test the hypothesis that a bradykinin B2 receptor antagonist would shorten time-to-resolution from ACE inhibitor-associated angioedema. METHODS: Patients with ACE inhibitor-associated angioedema (defined as swelling of lips, tongue, pharynx, or face during ACE inhibitor use and no swelling in the absence of ACE inhibitor use) were enrolled at Vanderbilt University Medical Center from October 2007 through September 2015 and at Massachusetts General Hospital in 2012...
November 29, 2016: Journal of Allergy and Clinical Immunology
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