keyword
https://read.qxmd.com/read/38480232/new-deep-water-species-of-augaptilidae-multicrustacea-copepoda-calanoida-from-the-arctic-ocean
#1
JOURNAL ARTICLE
Vladimir N Andronov, Ksenia N Kosobokova
Two new species of the calanoid copepod family Augaptilidae are described from specimens collected from bathypelagic depths of the Arctic Ocean. The female of Euaugaptilus verae sp. nov. can be distinguished from other congeneric species by 1) the Md tooth arrangement, 2) the structure of Mx1, and 3) the lack of external spines on Re2 and 3 of the female P5. The female of Alrhabdus antjeboetiusae sp. nov. can be distinguished from the only species of this genus, A. johrdeae Grice, 1973, by 1) the shape of the rostrum, 2) absence of paired spinal protrusions at the posterior corners of the last pedigerous somite, 3) position of spermatheca on the genital double-somite, 4) the Md tooth arrangement, and 5) P5 endopod 1-2 lacking modified medial setae...
February 14, 2024: Zootaxa
https://read.qxmd.com/read/38430986/letter-to-the-editor
#2
JOURNAL ARTICLE
Gloria R Grice, Margarita V DiVall, Jennifer L Adams, Jennifer A Campbell
No abstract text is available yet for this article.
February 29, 2024: American Journal of Pharmaceutical Education
https://read.qxmd.com/read/38429643/single-cell-rna-sequencing-reveals-peripheral-blood-leukocyte-responses-to-spinal-cord-injury-in-mice-with-humanised-immune-systems
#3
JOURNAL ARTICLE
Ellen R Gillespie, Laura F Grice, Isabel G Courtney, Hong Wa Lao, Woncheol Jung, Sonny Ramkomuth, Jacky Xie, David A Brown, James Walsham, Kristen J Radford, Quan H Nguyen, Marc J Ruitenberg
Next-generation humanised mouse models and single-cell RNA sequencing (scRNAseq) approaches enable in-depth studies into human immune cell biology. Here we used NSG-SGM3 mice engrafted with human umbilical cord haematopoietic stem cells to investigate how human immune cells respond to and/or are changed by traumatic spinal cord injury (SCI). We hypothesised that the use of such mice could help advance our understanding of spinal cord injury-induced immune depression syndrome (SCI-IDS), and also how human leukocytes change as they migrate from the circulation into the lesion site...
March 1, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38428400/an-electronic-data-capture-system-and-nursing-research-an-integrative-health-intervention-design-delivery-and-data-management-exemplar
#4
JOURNAL ARTICLE
Jennifer Withall, Jasmine Chau, Vincenza Coughlin, Alice Nash, Debra L Grice-Swenson, Sarah Kaplan, Victoria Marner, Diane Maydick-Youngberg, Kathleen Evanovich Zavotsky, Laura Gabbe
No abstract text is available yet for this article.
March 1, 2024: Computers, Informatics, Nursing: CIN
https://read.qxmd.com/read/38415632/an-exploration-of-mechanisms-underlying-desemzia-incerta-colonization-resistance-to-methicillin-resistant-staphylococcus-aureus-on-the-skin
#5
JOURNAL ARTICLE
Monica Wei, Simon A B Knight, Hossein Fazelinia, Lynn Spruce, Jennifer Roof, Emily Chu, Daniel Y Kim, Preeti Bhanap, Jasmine Walsh, Laurice Flowers, Jun Zhu, Elizabeth A Grice
Colonization of human skin and nares by methicillin-resistant Staphylococcus aureus (MRSA) leads to the community spread of MRSA. This spread is exacerbated by the transfer of MRSA between humans and livestock, particularly swine. Here, we capitalized on the shared features between human and porcine skin, including shared MRSA colonization, to study novel bacterial mediators of MRSA colonization resistance. We focused on the poorly studied bacterial species Desemzia incerta , which we found to exert antimicrobial activity through a secreted product and exhibited colonization resistance against MRSA in an in vivo murine skin model...
February 28, 2024: MSphere
https://read.qxmd.com/read/38385599/deep-subsurface-microbial-life-in-impact-altered-late-paleozoic-granitoid-rocks-from-the-chicxulub-impact-crater
#6
JOURNAL ARTICLE
Sohaib Naseer Quraish, Charles Cockell, Cornelia Wuchter, David Kring, Kliti Grice, Marco J L Coolen
In 2016, IODP-ICDP Expedition 364 recovered an 829-meter-long core within the peak ring of the Chicxulub impact crater (Yucatán, Mexico), allowing us to investigate the post-impact recovery of the heat-sterilized deep continental microbial biosphere at the impact site. We recently reported increased cell biomass in the impact suevite, which was deposited within the first few hours of the Cenozoic, and that the overall microbial communities differed significantly between the suevite and the other main core lithologies (i...
2024: Geobiology
https://read.qxmd.com/read/38360483/the-corbett-targeted-coin-test-reliability-criterion-related-validity-and-normative-data
#7
JOURNAL ARTICLE
Kimatha O Grice, Gustavo J Almeida
STUDY DESIGN: Clinical measurement. BACKGROUND: Many daily living tasks require in-hand manipulation (IHM). There is a gap in standardized assessment tools for measuring IHM. The Corbett Targeted Coin Test (CTCT) was designed to allow measurement of that fine motor skill. PURPOSE: 1) To evaluate the interrater, test-retest reliability, and validity of the CTCT, and 2) to establish adult norms for the CTCT. METHODS: Reliability and Validity - 30 participants (25 females, age range 21-45) were assessed with the Nine-Hole Peg test and CTCT consecutively by three researchers, then re-evaluated one week later on the CTCT; Reliability was determined using intraclass correlation (ICC2,k ) between tests and across testers; Criterion-related validity was determined by comparing scores from nine-hole test and CTCT across testers using ICC2,k ...
February 14, 2024: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://read.qxmd.com/read/38358004/auditory-processing-of-intonational-rises-and-falls-in-german-rises-are-special-in-attention-orienting
#8
JOURNAL ARTICLE
Maria Lialiou, Martine Grice, Christine T Röhr, Petra B Schumacher
This article investigates the processing of intonational rises and falls when presented unexpectedly in a stream of repetitive auditory stimuli. It examines the neurophysiological correlates (ERPs) of attention to these unexpected stimuli through the use of an oddball paradigm where sequences of repetitive stimuli are occasionally interspersed with a deviant stimulus, allowing for elicitation of a MMN. Whereas previous oddball studies on attention toward unexpected sounds involving pitch rises were conducted on nonlinguistic stimuli, the present study uses as stimuli lexical items in German with naturalistic intonation contours...
February 12, 2024: Journal of Cognitive Neuroscience
https://read.qxmd.com/read/38352457/transient-peripheral-blood-transcriptomic-response-to-ketamine-treatment-in-children-with-adnp-syndrome
#9
Ariela S Buxbaum Grice, Laura Sloofman, Tess Levy, Hannah Walker, Gauri Ganesh, Miguel Rodriguez de Los Santos, Pardis Armini, Joseph D Buxbaum, Alexander Kolevzon, Ana Kostic, Michael S Breen
Activity-dependent neuroprotective protein (ADNP) syndrome is a rare neurodevelopmental disorder resulting in intellectual disability, developmental delay and autism spectrum disorder (ASD) and is due to mutations in the ADNP gene. Ketamine treatment has emerged as a promising therapeutic option for ADNP syndrome, showing safety and apparent behavioral improvements in a first open label study. However, the molecular perturbations induced by ketamine remain poorly understood. Here, we investigated the longitudinal effect of ketamine on the blood transcriptome of 10 individuals with ADNP syndrome...
January 31, 2024: medRxiv
https://read.qxmd.com/read/38328427/otitis-media-recent-advances-in-otitis-media-vaccine-development-and-model-systems
#10
REVIEW
Ayesha Zahid, Jennifer C Wilson, I Darren Grice, Ian R Peak
Otitis media is an inflammatory disorder of the middle ear caused by airways-associated bacterial or viral infections. It is one of the most common childhood infections as globally more than 80% of children are diagnosed with acute otitis media by 3 years of age and it is a common reason for doctor's visits, antibiotics prescriptions, and surgery among children. Otitis media is a multifactorial disease with various genetic, immunologic, infectious, and environmental factors predisposing children to develop ear infections...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38281396/moraxella-ovis-and-moraxella-bovoculi-lipooligosaccharide-biosynthesis-genes-and-structural-characterisation-of-oligosaccharide-from-m-ovis-354t
#11
JOURNAL ARTICLE
Kosala S Ravikumaran, Rebecca M King, Anna Notaro, Antonio Molinaro, Cristina de Castro, Jennifer C Wilson, I Darren Grice, Ian R Peak
Moraxella ovis is a Gram-negative bacterium isolated from sheep conjunctivitis cases and is a rare isolate of infectious bovine keratoconjunctivitis (IBK). This species is closely related to M. bovoculi, another species which can also be isolated from IBK, or cattle upper respiratory tract (URT). Prior to molecular identification techniques, M. bovoculi was frequently misclassified as M. ovis. We previously described the structure of two oligosaccharides (lipooligosaccharide-derived, minor and major glycoforms) from M...
January 24, 2024: Carbohydrate Research
https://read.qxmd.com/read/38277476/spectral-analysis-of-non-contrast-fluoroscopy-for-evaluation-of-pulmonary-perfusion-feasibility-and-sensitivity-testing-with-a-phantom
#12
JOURNAL ARTICLE
Matthew R Smith, Jared V Grice, Dennis W Zhou, Erica C Emmons, Allman T Rollins, Anna R Hemnes, Jared M O'Leary, Gary T Smith
BACKGROUND: Oscillating x-ray attenuation in the lungs provides an opportunity to evaluate pulmonary perfusion without contrast. Recent intensity-based methods have been compared to pulmonary scintigraphy and CT angiography but lack rigorous phantom studies. PURPOSE: A new method to quantify the periodic signal amplitude was employed using spectral analysis. Performance was characterized using a water phantom capable of creating an oscillating x-ray attenuation at physiologic amplitudes...
January 26, 2024: Medical Physics
https://read.qxmd.com/read/38256867/hiv-1-transcription-inhibition-using-small-rna-binding-molecules
#13
JOURNAL ARTICLE
Pooja Khatkar, Gifty Mensah, Shangbo Ning, Maria Cowen, Yuriy Kim, Anastasia Williams, Fardokht A Abulwerdi, Yunjie Zhao, Chen Zeng, Stuart F J Le Grice, Fatah Kashanchi
The HIV-1 transactivator protein Tat interacts with the transactivation response element (TAR) at the three-nucleotide UCU bulge to facilitate the recruitment of transcription elongation factor-b (P-TEFb) and induce the transcription of the integrated proviral genome. Therefore, the Tat-TAR interaction, unique to the virus, is a promising target for developing antiviral therapeutics. Currently, there are no FDA-approved drugs against HIV-1 transcription, suggesting the need to develop novel inhibitors that specifically target HIV-1 transcription...
December 25, 2023: Pharmaceuticals
https://read.qxmd.com/read/38246416/predictive-dosimetry-and-outcomes-of-hepatocellular-carcinoma-treated-by-y90-resin-microsphere-radioembolization-a-retrospective-analysis-using-99mtc-maa-spect-ct-and-planning-software
#14
JOURNAL ARTICLE
Patrick W Doyle, C Spencer Workman, Jared V Grice, Trey W McGonigle, Shi Huang, Anthony J Borgmann, Jennifer C Baker, David P Duncan, Jason E Taylor, Daniel B Brown
PURPOSE: To characterize estimated tumor absorbed dose (ADT ), objective response (OR), and estimated target dose of hepatocellular carcinoma (HCC) following resin microsphere Yttrium-90 (Y90) radioembolization utilizing partition dosimetry. MATERIALS AND METHODS: In this retrospective, single-center study, multicompartment dosimetry of index tumors receiving Y90 radioembolization between October 2015-June 2022 was performed using MIM SurePlan and pre-treatment technetium-99m macroaggregated albumin SPECT/CT...
January 19, 2024: Journal of Vascular and Interventional Radiology: JVIR
https://read.qxmd.com/read/38168153/impact-of-crispr-hdr-editing-versus-lentiviral-transduction-on-long-term-engraftment-and-clonal-dynamics-of-hspcs-in-rhesus-macaques
#15
Byung-Chul Lee, Ashley Gin, Chuanfeng Wu, Komudi Singh, Max Grice, Ryland Mortlock, Diana Abraham, Xing Fan, Yifan Zhou, Aisha AlJanahi, Uimook Choi, Suk See de Ravin, Taehoon Shin, Sogun Hong, Cynthia E Dunbar
For precise genome editing via CRISPR/homology-directed repair (HDR), effective and safe editing of long-term engrafting hematopoietic stem cells (LT-HSCs) requires both sufficient HDR efficiency and protection of LT-HSC function and number. The impact of HDR on true LT-HSCs clonal dynamics in a relevant large animal model has not previously been studied. To track the HDR-edited cells, autologous rhesus macaque (RM) CD34 + cells were electroporated with the gRNA/Cas9 ribonucleoprotein (RNP) and HDR cassette barcode library structure and reinfused into RMs following myeloablation...
December 13, 2023: bioRxiv
https://read.qxmd.com/read/38140133/a-novel-handrub-tablet-loaded-with-pre-and-post-biotic-solid-lipid-nanoparticles-combining-virucidal-activity-and-maintenance-of-the-skin-barrier-and-microbiome
#16
JOURNAL ARTICLE
Ana Carolina Henriques Ribeiro Machado, Laís Júlio Marinheiro, Heather Ann Elizabeth Benson, Jeffrey Ernest Grice, Tereza da Silva Martins, Alexandra Lan, Patricia Santos Lopes, Newton Andreo-Filho, Vania Rodrigues Leite-Silva
OBJECTIVE: This study aimed to develop a holobiont tablet with rapid dispersibility to provide regulation of the microbiota, virucidal activity, and skin barrier protection. METHODS: A 23 factorial experiment was planned to define the best formulation for the development of the base tablet, using average weight, hardness, dimensions, swelling rate, and disintegration time as parameters to be analyzed. To produce holobiont tablets, the chosen base formulation was fabricated by direct compression of prebiotics, postbiotics, and excipients...
December 17, 2023: Pharmaceutics
https://read.qxmd.com/read/38127762/polycyclic-aromatic-hydrocarbons-in-samples-of-ryugu-formed-in-the-interstellar-medium
#17
JOURNAL ARTICLE
Sarah S Zeichner, José C Aponte, Surjyendu Bhattacharjee, Guannan Dong, Amy E Hofmann, Jason P Dworkin, Daniel P Glavin, Jamie E Elsila, Heather V Graham, Hiroshi Naraoka, Yoshinori Takano, Shogo Tachibana, Allison T Karp, Kliti Grice, Alex I Holman, Katherine H Freeman, Hisayoshi Yurimoto, Tomoki Nakamura, Takaaki Noguchi, Ryuji Okazaki, Hikaru Yabuta, Kanako Sakamoto, Toru Yada, Masahiro Nishimura, Aiko Nakato, Akiko Miyazaki, Kasumi Yogata, Masanao Abe, Tatsuaki Okada, Tomohiro Usui, Makoto Yoshikawa, Takanao Saiki, Satoshi Tanaka, Fuyuto Terui, Satoru Nakazawa, Sei-Ichiro Watanabe, Yuichi Tsuda, Kenji Hamase, Kazuhiko Fukushima, Dan Aoki, Minako Hashiguchi, Hajime Mita, Yoshito Chikaraishi, Naohiko Ohkouchi, Nanako O Ogawa, Saburo Sakai, Eric T Parker, Hannah L McLain, Francois-Regis Orthous-Daunay, Véronique Vuitton, Cédric Wolters, Philippe Schmitt-Kopplin, Norbert Hertkorn, Roland Thissen, Alexander Ruf, Junko Isa, Yasuhiro Oba, Toshiki Koga, Toshihiro Yoshimura, Daisuke Araoka, Haruna Sugahara, Aogu Furusho, Yoshihiro Furukawa, Junken Aoki, Kuniyuki Kano, Shin-Ichiro M Nomura, Kazunori Sasaki, Hajime Sato, Takaaki Yoshikawa, Satoru Tanaka, Mayu Morita, Morihiko Onose, Fumie Kabashima, Kosuke Fujishima, Tomoya Yamazaki, Yuki Kimura, John M Eiler
Polycyclic aromatic hydrocarbons (PAHs) contain ≲20% of the carbon in the interstellar medium. They are potentially produced in circumstellar environments (at temperatures ≳1000 kelvin), by (~10 kelvin) interstellar clouds, or by processing of carbon-rich dust grains. We report isotopic properties of PAHs extracted from samples of the asteroid Ryugu and the meteorite Murchison. The doubly-13 C substituted compositions (Δ2×13 C values) of the PAHs naphthalene, fluoranthene, and pyrene are 9 to 51‰ higher than values expected for a stochastic distribution of isotopes...
December 22, 2023: Science
https://read.qxmd.com/read/38057997/the-effect-of-water-coolant-and-bur-type-on-pulp-temperature-when-removing-tooth-structure-and-restorative-dental-materials
#18
JOURNAL ARTICLE
C Mafrici, M Kingston, R Grice, P V Abbott
OBJECTIVE: The aim was to compare intrapulp temperature (IPT) changes when flat-fissure diamond burs and pear-shaped tungsten carbide burs were used to cut tooth structure, amalgam, and composite resin with and without water coolant. METHODS: Thermocouples were inserted into the pulp chamber of extracted intact mandibular molars. The thermocouples were connected to an electronic thermometer that detects temperature every second to an accuracy of 0.1°C. IPT changes were recorded while using a high-speed handpiece during MOD cavity preparations (n=40), composite resin removal (n=40), and amalgam removal (n=40)...
December 6, 2023: Operative Dentistry
https://read.qxmd.com/read/38055372/investigating-the-immune-basis-of-green-tea-extract-induced-liver-injury-in-healthy-donors-expressing-hla-b-35-01
#19
JOURNAL ARTICLE
James Line, Serat-E Ali, Sophie Grice, Tai Rao, Dean J Naisbitt
Epigallocatechin-3- O -gallate (EGCG) is the major component of green tea extract, commonly found in dietary supplements, and has been associated with immune-mediated liver injury. The purpose of this study was to investigate the immunogenicity of EGCG in healthy donors expressing HLA-B*35:01, and characterize EGCG responsive T-cell clones. We have shown that EGCG can prime peripheral blood mononuclear cells and T-cells from donors with and without the HLA-B*35:01 allele. T-cell clones were CD4+ve and capable of secreting Th1, Th2, and cytolytic molecules...
December 6, 2023: Chemical Research in Toxicology
https://read.qxmd.com/read/38048695/reassessing-the-putative-molecular-target-s-of-potent-antitubercular-2-alkylsulfonyl-acetamides
#20
JOURNAL ARTICLE
Dylan C Farr, Thomas Haselhorst, Lendl Tan, Juanelle Furness, Emily Strong, I Darren Grice, Nicholas P West, Todd A Houston
Simple alkyl-sulfonylacetamides have potent antitubercular activity and significantly decrease mycolic acid levels in mycobacteria. Although these compounds were originally designed to inhibit the ketoacyl synthase domain of fatty acid synthase, structure-activity relationships and biochemical evidence do not fully support fatty acid synthase as the target. In 2004, an enzyme family involved in the activation and transfer of fatty acids as acyl-adenylates was identified in mycobacteria, separate from the universal acetyl-CoA carrier mechanism...
November 22, 2023: European Journal of Medicinal Chemistry
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