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https://www.readbyqxmd.com/read/29146988/variations-in-nutrient-and-trace-element-composition-of-rice-in-an-organic-rice-frog-coculture-system
#1
Zhimin Sha, Qingnan Chu, Zheng Zhao, Yubo Yue, Linfang Lu, Jing Yuan, Linkui Cao
Introducing frogs into paddy fields can control pests and diseases, and organic farming can improve soil fertility and rice growth. The aim of this 2-year field study was compare the yield and elemental composition of rice between an organic farming system including frogs (ORF) and a conventional rice culture system (CR). The grain yields were almost the same in the ORF system and the CR system. The ORF significantly increased the contents of phosphorus (P), ion (Fe), zinc (Zn), molybdenum (Mo) and selenium (Se) in rice grain at one or both years...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29141240/host-microbe-interactions-malassezia-and-human-skin
#2
REVIEW
Elizabeth A Grice, Thomas L Dawson
The skin is our first line of defense, protecting us from invasion and evaporation. Its variable structure, changing geography, and complex immune repertoire provide a vast interface for our cutaneous microbial community. Skin is inhabited by many thousands of microbes, but this review focuses on the dominant eukaryote, Malassezia, and its host interaction. Malassezia compromises 17 species with variable niche specificities and differing pathogenic potential. It has been known as a skin inhabitant for over 100 years, and is now accepted to be on all warm-blooded animals...
November 12, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/29131088/development-and-evaluation-of-lipid-nanoparticles-containing-natural-botanical-oil-for-sun-protection-characterization-and-in-vitro-and-in-vivo-human-skin-permeation-and-toxicity
#3
Newton Andréo-Filho, Antonio Vinicius Kosiski Bim, Telma Mary Kaneko, Nidia Ayumi Kitice, Isha N Haridass, Eman Abd, Patricia Santos Lopes, Sachin S Thakur, Harendra S Parekh, Michael S Roberts, Jeffrey E Grice, Heather A E Benson, Vânia Rodrigues Leite-Silva
The use of sunscreen products is widely promoted by schools, government agencies, and health-related organizations to minimize sunburn and skin damage. In this study, we developed stable solid lipid nanoparticles (SLNs) containing the chemical UV filter octyl methoxycinnamate (OMC). In parallel, we produced similar stable SLNs in which 20% of the OMC content was replaced by the botanical urucum oil. When these SLNs were applied to the skin of human volunteers, no changes in fluorescence lifetimes or redox ratios of the endogenous skin fluorophores were seen, suggesting that the formulations did not induce toxic responses in the skin...
November 4, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29104537/consciously-feeling-the-pain-of-others-reflects-atypical-functional-connectivity-between-the-pain-matrix-and-frontal-parietal-regions
#4
Thomas Grice-Jackson, Hugo D Critchley, Michael J Banissy, Jamie Ward
Around a quarter of the population report "mirror pain" experiences in which bodily sensations of pain are elicited in response to viewing another person in pain. We have shown that this population of responders further fractionates into two distinct subsets (Sensory/localized and Affective/General), which presents an important opportunity to investigate the neural underpinnings of individual differences in empathic responses. Our study uses fMRI to determine how regions involved in the perception of pain interact with regions implicated in empathic regulation in these two groups, relative to controls...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29100626/heritable-variation-with-little-or-no-maternal-effect-accounts-for-recurrence-risk-to-autism-spectrum-disorder-in-sweden
#5
Benjamin Hon Kei Yip, Dan Bai, Behrang Mahjani, Lambertus Klei, Yudi Pawitan, Christina M Hultman, Dorothy E Grice, Kathryn Roeder, Joseph D Buxbaum, Bernie Devlin, Abraham Reichenberg, Sven Sandin
BACKGROUND: Autism spectrum disorder (ASD) has both genetic and environmental origins, including potentially maternal effects. Maternal effects describe association of one or more maternal phenotypes with liability to ASD in progeny that are independent of maternally transmitted risk alleles. While maternal effects could play an important role, consistent with association to maternal traits such as immune status, no study has estimated maternal, additive genetic, and environmental effects in ASD...
September 21, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29099331/the-topological-train-ride-of-a-viral-long-non-coding-rna
#6
Joanna Sztuba-Solinska, Stuart F J Le Grice
As the notion of small molecule targeting of regulatory viral and cellular RNAs gathers momentum, understanding their structure, and variations thereof, in the appropriate biological context will play a critical role. This is especially true of the ∼1100-nt polyadenylated nuclear (PAN) long non-coding (lnc) RNA of Kaposi's sarcoma herpesvirus (KSHV), whose interaction with viral and cellular proteins is central to lytic infection. Nuclear accumulation of PAN RNA is mediated via a unique triple helical structure at its 3' terminus (within the expression and nuclear retention element, or ENE) which protects it from deadenylation-dependent decay...
November 3, 2017: RNA Biology
https://www.readbyqxmd.com/read/29098212/synthesis-and-biological-assessment-of-3-7-dihydroxytropolones
#7
D R Hirsch, D V Schiavone, A J Berkowitz, L A Morrison, T Masaoka, J A Wilson, E Lomonosova, H Zhao, B S Patel, S H Datla, S G Hoft, S J Majidi, R K Pal, E Gallicchio, L Tang, J E Tavis, S F J Le Grice, J A Beutler, R P Murelli
3,7-Dihydroxytropolones (3,7-dHTs) are highly oxygenated troponoids that have been identified as lead compounds for several human diseases. To date, structure-function studies on these molecules have been limited due to a scarcity of synthetic methods for their preparation. New synthetic strategies towards structurally novel 3,7-dHTs would be valuable in further studying their therapeutic potential. Here we describe the successful adaptation of a [5 + 2] oxidopyrilium cycloaddition/ring-opening for 3,7-dHT synthesis, which we apply in the synthesis of a plausible biosynthetic intermediate to the natural products puberulic and puberulonic acid...
November 3, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29061985/palaeobiology-of-red-and-white-blood-cell-like-structures-collagen-and-cholesterol-in-an-ichthyosaur-bone
#8
Chloé Plet, Kliti Grice, Anais Pagès, Michael Verrall, Marco J L Coolen, Wolfgang Ruebsam, William D A Rickard, Lorenz Schwark
Carbonate concretions are known to contain well-preserved fossils and soft tissues. Recently, biomolecules (e.g. cholesterol) and molecular fossils (biomarkers) were also discovered in a 380 million-year-old concretion, revealing their importance in exceptional preservation of biosignatures. Here, we used a range of microanalytical techniques, biomarkers and compound specific isotope analyses to report the presence of red and white blood cell-like structures as well as platelet-like structures, collagen and cholesterol in an ichthyosaur bone encapsulated in a carbonate concretion from the Early Jurassic (~182...
October 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29024079/the-preadolescent-acne-microbiome-a-prospective-randomized-pilot-study-investigating-characterization-and-effects-of-acne-therapy
#9
Carrie C Coughlin, Shane M Swink, Joseph Horwinski, Georgia Sfyroera, Julia Bugayev, Elizabeth A Grice, Albert C Yan
BACKGROUND/OBJECTIVES: Acne, a common pediatric disease, tends to be more comedonal in preadolescents, whereas older individuals are more likely to have inflammatory lesions in addition to comedones. Thus the microbiome of preadolescents may be different. In this pilot study we aimed to characterize the preadolescent acne microbiome, compare the microbiome in preadolescents with and without acne, and investigate changes in the microbiome after topical treatment with benzoyl peroxide or a retinoid in a small cohort of preadolescents...
October 11, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28956767/the-exonuclease-activity-of-hsv-1-ul12-is-required-for-the-production-of-viral-dna-that-can-be-packaged-to-produce-infectious-virus
#10
Lorry M Grady, Renata Szczepaniak, Ryan P Murelli, Takeshi Masaoka, Stuart F J Le Grice, Dennis L Wright, Sandra K Weller
The Herpes simplex virus type I alkaline nuclease, UL12, has 5' to 3' exonuclease activity and shares homology with nucleases from other members of the Herpesviridae family. We previously reported that a UL12 null virus exhibits a severe defect in viral growth. To determine whether the growth defect was a result of loss of nuclease activity or another function of UL12, we introduced an exonuclease-inactivating mutation into the viral genome. The recombinant virus, UL12-D340E (D340E), behaved identically to the null virus (AN-1) in virus yield experiments, exhibiting a 4-log decrease in the production of infectious virus...
September 27, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28934505/combining-asymmetric-13c-labeling-and-isotopic-filter-edit-noesy-a-novel-strategy-for-rapid-and-logical-rna-resonance-assignment
#11
Regan M LeBlanc, Andrew P Longhini, Stuart F J Le Grice, Bruce A Johnson, Theodore K Dayie
Although ∼98% of the human genomic output is transcribed as non-protein coding RNA, <2% of the protein data bank structures comprise RNA. This huge structural disparity stems from combined difficulties of crystallizing RNA for X-ray crystallography along with extensive chemical shift overlap and broadened linewidths associated with NMR of RNA. While half of the deposited RNA structures in the PDB were solved by NMR methods, the usefulness of NMR is still limited by the high cost of sample preparation and challenges of resonance assignment...
September 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28934172/topical-nano-and-microemulsions-for-skin-delivery
#12
REVIEW
Christofori M R R Nastiti, Thellie Ponto, Eman Abd, Jeffrey E Grice, Heather A E Benson, Michael S Roberts
Nanosystems such as microemulsions (ME) and nanoemulsions (NE) offer considerable opportunities for targeted drug delivery to and via the skin. ME and NE are stable colloidal systems composed of oil and water, stabilised by a mixture of surfactants and cosurfactants, that have received particular interest as topical skin delivery systems. There is considerable scope to manipulate the formulation components and characteristics to achieve optimal bioavailability and minimal skin irritancy. This includes the incorporation of established chemical penetration enhancers to fluidize the stratum corneum lipid bilayers, thus reducing the primary skin barrier and increasing permeation...
September 21, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28928194/diagnostic-validity-of-early-onset-obsessive-compulsive-disorder-in-the-danish-psychiatric-central-register-findings-from-a-cohort-sample
#13
Judith Nissen, Shelagh Powell, Susanne V Koch, James J Crowley, Manuel Matthiesen, Dorothy E Grice, Per H Thomsen, E Parner
OBJECTIVES: Employing national registers for research purposes depends on a high diagnostic validity. The aim of the present study was to examine the diagnostic validity of recorded diagnoses of early-onset obsessive-compulsive disorder (OCD) in the Danish Psychiatric Central Register (DPCR). DESIGN: Review of patient journals selected randomly through the DPCR. METHOD: One hundred cases of OCD were randomly selected from DPCR. Using a predefined coding scheme based on the Children's Yale Brown Obsessive Compulsive Scale (CYBOCS), experienced research nurse or child and adolescent psychiatrists assessed each journal to determine the presence/absence of OCD diagnostic criteria...
September 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28922333/rock-inhibitor-ripasudil-as-coadjuvant-after-descemetorhexis-without-an-endothelial-graft
#14
Virgilio Galvis, Alejandro Tello, Johanna P Fuquen, Carlos A Rodríguez-Barrientos, Juan Martín Grice
No abstract text is available yet for this article.
December 2017: Cornea
https://www.readbyqxmd.com/read/28921630/metabolic-assessment-of-a-migraine-model-using-relaxation-enhanced-1-h-spectroscopy-at-ultrahigh-field
#15
Nastaren Abad, Jens T Rosenberg, Tangi Roussel, Dillon C Grice, Michael G Harrington, Samuel C Grant
PURPOSE: This study evaluates biochemical imbalances in a rat model that reflects dysfunctional pathways in migraine. The high sensitivity and spectral dispersion available to (1) H MRS at 21.1 T expands metabolic profiling in this migraine model to include lactate (Lac), taurine (Tau), aspartate, and Gly-a mixture of glycine, glutamine, and glutamate. METHODS: Sprague-Dawley male rats were administered in situ an intraperitoneal injection of nitroglycerin (NTG) to induce the migraine analogue or saline as a control...
September 17, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28805739/four-bad-habits-of-modern-psychologists
#16
James Grice, Paul Barrett, Lisa Cota, Crystal Felix, Zachery Taylor, Samantha Garner, Eliwid Medellin, Adam Vest
Four data sets from studies included in the Reproducibility Project were re-analyzed to demonstrate a number of flawed research practices (i.e., "bad habits") of modern psychology. Three of the four studies were successfully replicated, but re-analysis showed that in one study most of the participants responded in a manner inconsistent with the researchers' theoretical model. In the second study, the replicated effect was shown to be an experimental confound, and in the third study the replicated statistical effect was shown to be entirely trivial...
August 14, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/28759805/common-and-distinct-neural-mechanisms-associated-with-the-conscious-experience-of-vicarious-pain
#17
Thomas Grice-Jackson, Hugo D Critchley, Michael J Banissy, Jamie Ward
Vicarious pain perception has been an influential paradigm for investigating the social neuroscience of empathy. This research has highlighted the importance of both shared representations (i.e., involved in both experiencing first-hand physical pain and observing pain) and mechanisms that discriminate between self and other. The majority of this research has been conducted in healthy younger adults using a group-average approach. There are, however, known inter-individual differences that can contribute to vicarious experience...
July 3, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28720042/exotic-dancing-and-relationship-violence-exploring-indigeneity-gender-and-agency
#18
Jade Le Grice
How should we begin to explore the complex considerations influencing young Indigenous New Zealand Māori women's sexuality? Centring a Māori woman's analysis through a Mana Wāhine methodology, and utilising an Indigenous form of storying, pūrākau, I explore this question by attending to my autobiographical memory of experiences of exotic dancing and moments of violence in heterosexual relationships. The analysis provides critical reflection on the interchanges between individual experience and the social and cultural conditions of a reality, informed by colonisation and historical trauma...
July 19, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/28669672/cutaneous-leishmaniasis-induces-a-transmissible-dysbiotic-skin-microbiota-that-promotes-skin-inflammation
#19
Ciara Gimblet, Jacquelyn S Meisel, Michael A Loesche, Stephen D Cole, Joseph Horwinski, Fernanda O Novais, Ana M Misic, Charles W Bradley, Daniel P Beiting, Shelley C Rankin, Lucas P Carvalho, Edgar M Carvalho, Phillip Scott, Elizabeth A Grice
Skin microbiota can impact allergic and autoimmune responses, wound healing, and anti-microbial defense. We investigated the role of skin microbiota in cutaneous leishmaniasis and found that human patients infected with Leishmania braziliensis develop dysbiotic skin microbiota, characterized by increases in the abundance of Staphylococcus and/or Streptococcus. Mice infected with L. major exhibit similar changes depending upon disease severity. Importantly, this dysbiosis is not limited to the lesion site, but is transmissible to normal skin distant from the infection site and to skin from co-housed naive mice...
July 12, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28630195/topical-antimicrobial-treatments-can-elicit-shifts-to-resident-skin-bacterial-communities-and-reduce-colonization-by-staphylococcus-aureus-competitors
#20
Adam J SanMiguel, Jacquelyn S Meisel, Joseph Horwinski, Qi Zheng, Elizabeth A Grice
The skin microbiome is a complex ecosystem with important implications for cutaneous health and disease. Topical antibiotics and antiseptics are often employed to preserve the balance of this population and inhibit colonization by more pathogenic bacteria. However, despite their widespread use, the impact of these interventions on broader microbial communities remains poorly understood. Here, we report the longitudinal effects of topical antibiotics and antiseptics on skin bacterial communities and their role in Staphylococcus aureus colonization resistance...
September 2017: Antimicrobial Agents and Chemotherapy
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