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Yue Yu, Changlei Wang, Corey R Grice, Niraj Shrestha, Jing Chen, Dewei Zhao, Weiqiang Liao, Alexander J Cimaroli, Paul J Roland, Randy J Ellingson, Yanfa Yan
Formamidinium lead triiodide (FAPbI3 ) is considered as an alternative to methylammonium lead triiodide (MAPbI3 ) because of its lower band gap and better thermal stability. However, owing to the large size of FA cations, it is difficult to synthesize high-quality FAPbI3 thin films without the formation of an undesirable yellow phase. Smaller sized cations, such as MA and Cs, have been successfully used to suppress the formation of the yellow phase. Whereas FA and MA lead triiodide perovskite solar cells (PVSCs) have achieved power conversion efficiencies (PCEs) higher than 20 %, the PCEs of formamidinium and cesium lead triiodide (FA1-x Csx PbI3 ) PVSCs have been only approximately 16...
October 26, 2016: ChemSusChem
Keisha Findley, David R Williams, Elizabeth A Grice, Vence L Bonham
An individual's microbiome is likely to be an important contributor to certain health disparity diseases and conditions. We present a framework to study the role of the microbiome and the multiple factors that are likely to influence differences in disease predisposition, onset, and progression at the individual and population level.
November 2016: Trends in Microbiology
Qi Zheng, Elizabeth A Grice
Accurate mapping of next-generation sequencing (NGS) reads to reference genomes is crucial for almost all NGS applications and downstream analyses. Various repetitive elements in human and other higher eukaryotic genomes contribute in large part to ambiguously (non-uniquely) mapped reads. Most available NGS aligners attempt to address this by either removing all non-uniquely mapping reads, or reporting one random or "best" hit based on simple heuristics. Accurate estimation of the mapping quality of NGS reads is therefore critical albeit completely lacking at present...
October 2016: PLoS Computational Biology
S K Lengger, J Fromont, K Grice
Over 8600 species are currently recorded in the phylum Porifera (sponges). They produce a large diversity of biochemical compounds including sterols, with more than 250 different sterols identified. Some of these sterols are of great interest, due to their use for fingerprinting in ecological and biomarker (molecular fossil) studies. As a large number of identified extant species from biodiversity surveys are housed in museum collections, preserved in ethanol, these present a potentially rich source of identified specimens for comparative lipid analyses...
September 29, 2016: Geobiology
Gui Tran, Toby O Smith, Adam Grice, Sarah R Kingsbury, Paul McCrory, Philip G Conaghan
BACKGROUND: To assess the relationship between sport and osteoarthritis (OA), and specifically to determine whether previous participation, in terms of level (elite or non-elite), type of sport, intensity or previous injury, was associated with OA. METHODS: This systematic review was developed using PRISMA guidelines. Databases were searched (to May 2016). Narrative review and meta-analysis (with risk ratio (RR) and 95% CIs) approaches were undertaken where appropriate...
September 28, 2016: British Journal of Sports Medicine
John Grice, Daniel Marsland, George Smith, James Calder
BACKGROUND: Corticosteroid injections have been used for a variety of foot and ankle pathologies over the years, and our aim was to evaluate the efficacy and safety of them in our clinic. MATERIALS AND METHODS: We performed a retrospective review of notes and a telephone questionnaire on the clinical outcome of all patients who underwent a corticosteroid injection of the foot or ankle in a year. All procedures were performed in an outpatient setting by a consultant musculoskeletal radiologist using either ultrasound or X-ray guidance and had a minimum of 2 years of follow-up...
September 25, 2016: Foot & Ankle International
Joanna Sztuba-Solinska, Larissa Diaz, Mia R Kumar, Gaëlle Kolb, Michael R Wiley, Lucas Jozwick, Jens H Kuhn, Gustavo Palacios, Sheli R Radoshitzky, Stuart F J Le Grice, Reed F Johnson
Ebola virus (EBOV) is a single-stranded negative-sense RNA virus belonging to the Filoviridae family. The leader and trailer non-coding regions of the EBOV genome likely regulate its transcription, replication, and progeny genome packaging. We investigated the cis-acting RNA signals involved in RNA-RNA and RNA-protein interactions that regulate replication of eGFP-encoding EBOV minigenomic RNA and identified heat shock cognate protein family A (HSC70) member 8 (HSPA8) as an EBOV trailer-interacting host protein...
September 19, 2016: Nucleic Acids Research
Shereen Yousef, Yousuf Mohammed, Sarika Namjoshi, Jeffrey Grice, Wedad Sakran, Michael Roberts
We sought to understand when and how hydration enhances the percutaneous absorption of salicylate esters. Human epidermal membrane fluxes and stratum corneum solubilities of neat and diluted solutions of three esters were determined under hydrated and dehydrated conditions. Hydration doubled the human epidermal flux seen for methyl and ethyl salicylate under dehydrated conditions and increased the flux of neat glycol salicylate 10-fold. Mechanistic analyses showed that this hydration-induced enhancement arises mainly from an increase in the stratum corneum diffusivity of the three esters...
September 15, 2016: AAPS Journal
Navin Chandrakanth Chandrasekaran, Washington Y Sanchez, Yousuf H Mohammed, Jeffrey E Grice, Michael S Roberts, Ross T Barnard
Magnesium is an important micronutrient essential for various biological processes and its deficiency has been linked to several inflammatory disorders in humans. Topical magnesium delivery is one of the oldest forms of therapy for skin diseases, for example Dead Sea therapy and Epsom salt baths. Some anecdotal evidence and a few published reports have attributed amelioration of inflammatory skin conditions to the topical application of magnesium. On the other hand, transport of magnesium ions across the protective barrier of skin, the stratum corneum, is contentious...
June 1, 2016: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
Weiqiang Liao, Dewei Zhao, Yue Yu, Niraj Shrestha, Kiran Ghimire, Corey R Grice, Changlei Wang, Yuqing Xiao, Alexander J Cimaroli, Randy J Ellingson, Nikolas J Podraza, Kai Zhu, Ren-Gen Xiong, Yanfa Yan
Mixed tin (Sn)-lead (Pb) perovskites with high Sn content exhibit low bandgaps suitable for fabricating the bottom cell of perovskite-based tandem solar cells. In this work, we report on the fabrication of efficient mixed Sn-Pb perovskite solar cells using precursors combining formamidinium tin iodide (FASnI3) and methylammonium lead iodide (MAPbI3). The best-performing cell fabricated using a (FASnI3)0.6(MAPbI3)0.4 absorber with an absorption edge of ∼1.2 eV achieved a power conversion efficiency (PCE) of 15...
September 28, 2016: Journal of the American Chemical Society
Lindsay Kalan, Michael Loesche, Brendan P Hodkinson, Kristopher Heilmann, Gordon Ruthel, Sue E Gardner, Elizabeth A Grice
UNLABELLED: Chronic nonhealing wounds have been heralded as a silent epidemic, causing significant morbidity and mortality especially in elderly, diabetic, and obese populations. Polymicrobial biofilms in the wound bed are hypothesized to disrupt the highly coordinated and sequential events of cutaneous healing. Both culture-dependent and -independent studies of the chronic-wound microbiome have almost exclusively focused on bacteria, omitting what we hypothesize are important fungal contributions to impaired healing and the development of complications...
2016: MBio
Weiqiang Liao, Dewei Zhao, Yue Yu, Corey R Grice, Changlei Wang, Alexander J Cimaroli, Philip Schulz, Weiwei Meng, Kai Zhu, Ren-Gen Xiong, Yanfa Yan
Efficient lead (Pb)-free inverted planar formamidinium tin triiodide (FASnI3 ) perovskite solar cells (PVSCs) are demonstrated. Our FASnI3 PVSCs achieved average power conversion efficiencies (PCEs) of 5.41% ± 0.46% and a maximum PCE of 6.22% under forward voltage scan. The PVSCs exhibit small photocurrent-voltage hysteresis and high reproducibility. The champion cell showed a steady-state efficiency of ≈6.00% for over 100 s.
August 29, 2016: Advanced Materials
Michael Loesche, Sue E Gardner, Lindsay Kalan, Joseph Horwinski, Qi Zheng, Brendan P Hodkinson, Amanda S Tyldsley, Carrie L Franciscus, Stephen L Hillis, Samir Mehta, David J Margolis, Elizabeth A Grice
Microbial burden of chronic wounds is believed to play an important role in impaired healing and the development of infection-related complications. However, clinical cultures have little predictive value of wound outcomes, and culture-independent studies have been limited by cross-sectional design and small cohort size. We systematically evaluated the temporal dynamics of the microbiota colonizing diabetic foot ulcers, a common and costly complication of diabetes, and its association with healing and clinical complications...
August 24, 2016: Journal of Investigative Dermatology
Youping Zhou, Kliti Grice, Hilary Stuart-Williams, Charles H Hocart, Arthur Gessler, Graham D Farquhar
The (2) H/(1) H ratio of carbon-bound H in biolipids holds potential for probing plant lipid biosynthesis and metabolism. The biochemical mechanism underlying the isotopic differences between lipids from C3 and C4 plants is still poorly understood. GC-pyrolysis-IRMS (gas chromatography-pyrolysis-isotope ratio mass spectrometry) measurement of the (2) H/(1) H ratio of leaf lipids from controlled and field grown plants indicates that the biochemical isotopic fractionation (ε(2) Hlipid_biochem ) differed between C3 and C4 plants in a pathway-dependent manner: ε(2) HC4  > ε(2) HC3 for the acetogenic pathway, ε(2) HC4  < ε(2) HC3 for the mevalonic acid pathway and the 1-deoxy-D-xylulose 5-phosphate pathway across all species examined...
August 27, 2016: Plant, Cell & Environment
Heidi A Browne, Amirhossein Modabbernia, Joseph D Buxbaum, Stefan N Hansen, Diana E Schendel, Erik T Parner, Abraham Reichenberg, Dorothy E Grice
OBJECTIVE: We assessed the role of prenatal maternal smoking in risk for Tourette syndrome and chronic tic disorder (TS/CT) and pediatric-onset obsessive-compulsive disorder (OCD). METHOD: In an analysis of 73,073 singleton pregnancies from the Danish National Birth Cohort, we calculated incidence rates (IR) per 1,000 person-year for TS/CT and OCD. We then determined crude and adjusted hazard ratios and 95% CIs associated with prenatal maternal smoking, considering smoking as a dichotomous (yes/no) variable or a stratified variable (no smoking, light smoking, and heavy smoking [≥10 cigarettes/day])...
September 2016: Journal of the American Academy of Child and Adolescent Psychiatry
Mohamed Abdulkadir, Jay A Tischfield, Robert A King, Thomas V Fernandez, Lawrence W Brown, Keun-Ah Cheon, Barbara J Coffey, Sebastian F T M de Bruijn, Lonneke Elzerman, Blanca Garcia-Delgar, Donald L Gilbert, Dorothy E Grice, Julie Hagstrøm, Tammy Hedderly, Isobel Heyman, Hyun Ju Hong, Chaim Huyser, Laura Ibanez-Gomez, Young Key Kim, Young-Shin Kim, Yun-Joo Koh, Sodahm Kook, Samuel Kuperman, Andreas Lamerz, Bennett Leventhal, Andrea G Ludolph, Marcos Madruga-Garrido, Athanasios Maras, Marieke D Messchendorp, Pablo Mir, Astrid Morer, Alexander Münchau, Tara L Murphy, Thaïra J C Openneer, Kerstin J Plessen, Judith J G Rath, Veit Roessner, Odette Fründt, Eun-Young Shin, Deborah A Sival, Dong-Ho Song, Jungeun Song, Anne-Marie Stolte, Jennifer Tübing, Els van den Ban, Frank Visscher, Sina Wanderer, Martin Woods, Samuel H Zinner, Matthew W State, Gary A Heiman, Pieter J Hoekstra, Andrea Dietrich
Pre- and perinatal complications have been implicated in the onset and clinical expression of Tourette syndrome albeit with considerable inconsistencies across studies. Also, little is known about their role in co-occurring obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD) in individuals with a tic disorder. Therefore, we aimed to investigate the role of pre- and perinatal complications in relation to the presence and symptom severity of chronic tic disorder and co-occurring OCD and ADHD using data of 1113 participants from the Tourette International Collaborative Genetics study...
November 2016: Journal of Psychiatric Research
Gregor Walczak
Within the Gricean framework only what is conversationally implicated is cancellable, whereas what is conventionally implicated and what is said cannot be cancelled without giving rise to contradiction. In the relevance-theoretic framework, however, the question is whether explicatures, which replace the Gricean notion of what is said, are cancellable. In recent years, various objections to the cancellability of explicatures have been raised. The aim of the present paper is to demonstrate that these objections are due to a misinterpretation of the Gricean cancellability test...
2016: SpringerPlus
Mahipal Ganji, Margreet Docter, Stuart F J Le Grice, Elio A Abbondanzieri
Finding the target site and associating in a specific orientation are essential tasks for DNA-binding proteins. In order to make the target search process as efficient as possible, proteins should not only rapidly diffuse to the target site but also dynamically explore multiple local configurations before diffusing away. Protein flipping is an example of this second process that has been observed previously, but the underlying mechanism of flipping remains unclear. Here, we probed the mechanism of protein flipping at the single molecule level, using HIV-1 reverse transcriptase (RT) as a model system...
September 30, 2016: Nucleic Acids Research
Abu Hasanat Md Zulfiker, Mohsen Sohrabi, Ji Qi, Ben Matthews, Ming Q Wei, I Darren Grice
Toad skins and venom glandular secretions have been widely used for centuries in traditional Chinese and Japanese medicine for the treatment of various ailments such as cancer, sores, toothache, local inflammation and pain. The active chemical constituents from traditional oriental medicines have demonstrated potential in the development of effective therapeutic pharmaceuticals. Our primary focus in this research was to identify and characterise 'active' compounds or groups of compounds for their potential as neuropsychiatric disorder therapeutics...
September 10, 2016: Journal of Pharmaceutical and Biomedical Analysis
Katarzyna Pachulska-Wieczorek, Stuart F J Le Grice, Katarzyna J Purzycka
Long-terminal repeat (LTR) retrotransposons are transposable genetic elements that replicate intracellularly, and can be considered progenitors of retroviruses. Ty1 and Ty3 are the most extensively characterized LTR retrotransposons whose RNA genomes provide the template for both protein translation and genomic RNA that is packaged into virus-like particles (VLPs) and reverse transcribed. Genomic RNAs are not divided into separate pools of translated and packaged RNAs, therefore their trafficking and packaging into VLPs requires an equilibrium between competing events...
2016: Viruses
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