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https://www.readbyqxmd.com/read/29036523/stress-dependent-association-between-polygenic-risk-for-schizophrenia-and-schizotypal-traits-in-young-army-recruits
#1
Alex Hatzimanolis, Dimitrios Avramopoulos, Dan E Arking, Anna Moes, Pallav Bhatnagar, Todd Lencz, Anil K Malhotra, Stella G Giakoumaki, Panos Roussos, Nikolaos Smyrnis, Panos Bitsios, Nicholas C Stefanis
Schizotypal personality traits may increase proneness to psychosis and likely index familial vulnerability to schizophrenia (SZ), implying shared genetic determinants with SZ. Here, we sought to investigate the contribution of common genetic risk variation for SZ on self-reported schizotypy in 2 ethnically homogeneous cohorts of healthy young males during compulsory military service, enrolled in the Athens Study of Proneness and Incidence of Schizophrenia (ASPIS, N = 875) and the Learning on Genetics of Schizophrenia Spectrum study (LOGOS, N = 690)...
June 13, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28959355/selective-isolation-and-screening-of-actinobacteria-strains-producing-lignocellulolytic-enzymes-using-olive-pomace-as-substrate
#2
Lamia Medouni-Haroune, Farid Zaidi, Sonia Medouni-Adrar, Sevastianos Roussos, Samia Azzouz, Véronique Desseaux, Mouloud Kecha
BACKGROUND: Olive pomace, as the main by-product of the olive oil industry, is recently recycled as fermentation substrate for enzyme production. OBJECTIVES: Actinobacteria isolates were separated from an Algerian soil under olive pomace cultivation and were evaluated for their lignocellulolytic enzymes production. MATERIALS AND METHODS: Isolates of Actinobacteria were separated from soils around oil mills using four isolation media, among them three were enriched by olive pomace...
March 2017: Iranian journal of biotechnology
https://www.readbyqxmd.com/read/28931188/congenital-ear-malformations-effectively-correcting-cryptotia-with-neonatal-ear-molding
#3
Collin Rozanski, Joseph J Rousso
No abstract text is available yet for this article.
September 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28892060/a-functional-genomics-predictive-network-model-identifies-regulators-of-inflammatory-bowel-disease
#4
Lauren A Peters, Jacqueline Perrigoue, Arthur Mortha, Alina Iuga, Won-Min Song, Eric M Neiman, Sean R Llewellyn, Antonio Di Narzo, Brian A Kidd, Shannon E Telesco, Yongzhong Zhao, Aleksandar Stojmirovic, Jocelyn Sendecki, Khader Shameer, Riccardo Miotto, Bojan Losic, Hardik Shah, Eunjee Lee, Minghui Wang, Jeremiah J Faith, Andrew Kasarskis, Carrie Brodmerkel, Mark Curran, Anuk Das, Joshua R Friedman, Yoshinori Fukui, Mary Beth Humphrey, Brian M Iritani, Nicholas Sibinga, Teresa K Tarrant, Carmen Argmann, Ke Hao, Panos Roussos, Jun Zhu, Bin Zhang, Radu Dobrin, Lloyd F Mayer, Eric E Schadt
A major challenge in inflammatory bowel disease (IBD) is the integration of diverse IBD data sets to construct predictive models of IBD. We present a predictive model of the immune component of IBD that informs causal relationships among loci previously linked to IBD through genome-wide association studies (GWAS) using functional and regulatory annotations that relate to the cells, tissues, and pathophysiology of IBD. Our model consists of individual networks constructed using molecular data generated from intestinal samples isolated from three populations of patients with IBD at different stages of disease...
October 2017: Nature Genetics
https://www.readbyqxmd.com/read/28782404/does-first-trimester-nuchal-cord-affect-the-blood-flow-in-the-ductus-venosus-a-prospective-observational-study
#5
S Petousis, C Margioula-Siarkou, A Mamopoulos, A Sotiriadis, D Rousso, A Athanasiadis, T Dagklis
INTRODUCTION: Main objective of the present study was to investigate the association between the presence of nuchal cord (NC) and the measurement of the ductus venosus pulsatility index for veins. (Ductus venosus (DV) PIV) Methods: This was a prospective study of 1974 singleton pregnancies that underwent first trimester screening at 11-13 + 6 gestational weeks. Colour Doppler was used to demonstrate the presence of a NC in all cases and the DV PIV was calculated routinely, as part of the standard scan...
August 7, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28758885/dimensional-traits-of-schizotypy-associated-with-glycine-receptor-glra1-polymorphism-an-exploratory-candidate-gene-association-study
#6
Anvi K Vora, Amanda M Fisher, Antonia S New, Erin A Hazlett, Margaret McNamara, Qiaoping Yuan, Zhifeng Zhou, Colin Hodgkinson, David Goldman, Larry J Siever, Panos Roussos, M Mercedes Perez-Rodriguez
Schizotypy captures the underlying genetic vulnerability to schizophrenia. However, the genetic underpinnings of schizotypy remain unexplored. The authors examined the relationship between single nucleotide polymorphisms (SNPs) and schizotypy. A sample of 137 subjects (43 healthy controls, 34 subjects with schizotypal personality disorder [SPD], 32 with borderline personality disorder, and 25 with other personality disorders) completed the Schizotypal Personality Questionnaire (SPQ). Subjects were genotyped using a custom array chip...
July 31, 2017: Journal of Personality Disorders
https://www.readbyqxmd.com/read/28753612/four-alpha-ganglion-cell-types-in-mouse-retina-function-structure-and-molecular-signatures
#7
Brenna Krieger, Mu Qiao, David L Rousso, Joshua R Sanes, Markus Meister
The retina communicates with the brain using ≥30 parallel channels, each carried by axons of distinct types of retinal ganglion cells. In every mammalian retina one finds so-called "alpha" ganglion cells (αRGCs), identified by their large cell bodies, stout axons, wide and mono-stratified dendritic fields, and high levels of neurofilament protein. In the mouse, three αRGC types have been described based on responses to light steps: On-sustained, Off-sustained, and Off-transient. Here we employed a transgenic mouse line that labels αRGCs in the live retina, allowing systematic targeted recordings...
2017: PloS One
https://www.readbyqxmd.com/read/28686855/large-scale-identification-of-common-trait-and-disease-variants-affecting-gene-expression
#8
Mads Engel Hauberg, Wen Zhang, Claudia Giambartolomei, Oscar Franzén, David L Morris, Timothy J Vyse, Arno Ruusalepp, Pamela Sklar, Eric E Schadt, Johan L M Björkegren, Panos Roussos
No abstract text is available yet for this article.
July 6, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28685207/clinical-effects-of-long-term-cardiac-contractility-modulation-ccm-in-subjects-with-heart-failure-caused-by-left-ventricular-systolic-dysfunction
#9
D Müller, A Remppis, P Schauerte, S Schmidt-Schweda, D Burkhoff, B Rousso, D Gutterman, J Senges, G Hindricks, K-H Kuck
INTRODUCTION: Heart failure is a major cause of morbidity and mortality throughout the world. Despite advances in therapy, nearly half of patients receiving guideline-directed medical therapy remain limited by symptoms. Cardiac contractility modulation (CCM) can improve symptoms in this population, but efficacy and safety in prospective studies has been limited to 12 months of follow-up. We report on the first 2 year multi-site evaluation of CCM in patients with heart failure. METHODS: One hundred and forty-three subjects with heart failure and reduced ejection fraction were followed via clinical registry for 24 months recording NYHA class, MLWHFQ score, 6 min walk distance, LVEF, and peak VO2 at baseline and 6 month intervals as clinically indicated...
July 6, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28671686/the-methyltransferase-setdb1-regulates-a-large-neuron-specific-topological-chromatin-domain
#10
Yan Jiang, Yong-Hwee Eddie Loh, Prashanth Rajarajan, Teruyoshi Hirayama, Will Liao, Bibi S Kassim, Behnam Javidfar, Brigham J Hartley, Lisa Kleofas, Royce B Park, Benoit Labonte, Seok-Man Ho, Sandhya Chandrasekaran, Catherine Do, Brianna R Ramirez, Cyril J Peter, Julia T C W, Brian M Safaie, Hirofumi Morishita, Panos Roussos, Eric J Nestler, Anne Schaefer, Benjamin Tycko, Kristen J Brennand, Takeshi Yagi, Li Shen, Schahram Akbarian
We report locus-specific disintegration of megabase-scale chromosomal conformations in brain after neuronal ablation of Setdb1 (also known as Kmt1e; encodes a histone H3 lysine 9 methyltransferase), including a large topologically associated 1.2-Mb domain conserved in humans and mice that encompasses >70 genes at the clustered protocadherin locus (hereafter referred to as cPcdh). The cPcdh topologically associated domain (TAD(cPcdh)) in neurons from mutant mice showed abnormal accumulation of the transcriptional regulator and three-dimensional (3D) genome organizer CTCF at cryptic binding sites, in conjunction with DNA cytosine hypomethylation, histone hyperacetylation and upregulated expression...
August 2017: Nature Genetics
https://www.readbyqxmd.com/read/28552197/large-scale-identification-of-common-trait-and-disease-variants-affecting-gene-expression
#11
Mads Engel Hauberg, Wen Zhang, Claudia Giambartolomei, Oscar Franzén, David L Morris, Timothy J Vyse, Arno Ruusalepp, Pamela Sklar, Eric E Schadt, Johan L M Björkegren, Panos Roussos
Genome-wide association studies (GWASs) have identified a multitude of genetic loci involved with traits and diseases. However, it is often unclear which genes are affected in such loci and whether the associated genetic variants lead to increased or decreased gene function. To mitigate this, we integrated associations of common genetic variants in 57 GWASs with 24 studies of expression quantitative trait loci (eQTLs) from a broad range of tissues by using a Mendelian randomization approach. We discovered a total of 3,484 instances of gene-trait-associated changes in expression at a false-discovery rate < 0...
June 1, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28509888/cardiac-contractility-modulation-a-technical-guide-for-device-implantation
#12
Jürgen Kuschyk, Axel Kloppe, Stephan Schmidt-Schweda, Hendrik Bonnemeier, Benny Rousso, Susanne Röger
This article provides a technical description of common implant practice for delivery of cardiac contractility modulation (CCM) therapy to heart failure patients. As of September 2016, the authors of this article collectively have been involved with more than 400 system implantations in five medical centers, beginning with the advent of CCM therapy approximately 12 years ago. CCM therapy has been evaluated in a variety of studies, and was shown to be safe and effective and of benefit to patient quality of life and exercise capacity...
2017: Reviews in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28486356/epidemiologic-surveillance-of-teenage-birth-rates-in-the-united-states-2006-2012
#13
Raid Amin, Julie Zemaitis Decesare, Jennifer Hans, Kay Roussos-Ross
OBJECTIVE: To investigate the geographic variation in the average teenage birth rates by county in the contiguous United States. METHODS: Data from the National Center for Health Statistics were used in this retrospective cohort to count the total number of live births to females aged 15-19 years by county between 2006 and 2012. Software for disease surveillance and spatial cluster analysis was used to identify clusters of high or low teenage births in counties or areas of greater than 100,000 teenage females...
June 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28432985/lif-endometrial-expression-is-impaired-in-women-with-unexplained-infertility-while-lif-r-expression-in-all-infertility-sub-groups
#14
Chrysoula Margioula-Siarkou, Yannis Prapas, Stamatios Petousis, Stefanos Milias, Konstantinos Ravanos, Themistoklis Dagklis, Ioannis Kalogiannidis, George Mavromatidis, Constantinos Haitoglou, Nikolaos Prapas, David Rousso
The main objective of our study was to study LIF and LIF-R endometrial expression during the implantation window in the various sub-groups of infertile women according to infertility cause. A prospective observational case-control study was performed from March 2013 to February 2016. Infertile women consisted of the patients' group (group 2) while fertile women were the control group (group 1). Infertile women were divided according to infertility cause in women with tubal factor (group 2a), poor ovarian reserve (group 2b), endometriosis (group 2c) and unexplained infertility (group 2d)...
April 19, 2017: Cytokine
https://www.readbyqxmd.com/read/28431175/minepath-org-a-free-interactive-pathway-analysis-web-server
#15
Lefteris Koumakis, Panos Roussos, George Potamias
Minepath (www.minepath.org) is a web-based platform that elaborates on, and radically extends the identification of differentially expressed sub-paths in molecular pathways. Besides the network topology, the underlying MinePath algorithmic processes exploit exact gene-gene molecular relationships (e.g. activation, inhibition) and are able to identify differentially expressed pathway parts. Each pathway is decomposed into all its constituent sub-paths, which in turn are matched with corresponding gene expression profiles...
April 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28396239/microvascular-anomaly-conditions-in-psychiatric-disease-schizophrenia-angiogenesis-connection
#16
REVIEW
Pavel Katsel, Panos Roussos, Mikhail Pletnikov, Vahram Haroutunian
Schizophrenia (SZ) is a severe mental disorder with unknown etiology and elusive neuropathological and neurobiological features have been a focus of many theoretical hypotheses and empirical studies. Current genetic and neurobiology information relevant to SZ implicates neuronal developmental and synaptic plasticity abnormalities, and neurotransmitter, microglial and oligodendrocytes dysfunction. Several recent theories have highlighted the neurovascular unit as a potential contributor to the pathophysiology of SZ...
June 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28384792/determining-the-2-dimensional-threshold-for-perception-of-artificial-appearing-lips
#17
Sang W Kim, Daniel E Rousso
Importance: Recognizing the perceptual threshold for artificial-appearing lips is important to avoid an undesirable outcome of treatment. Objective: To characterize the quantitative measurements for the perceptual threshold of artificial- and unnatural-appearing lips. Design, Setting, and Participants: Photographs of a female model's lips were digitally altered incrementally in 5 sets of features (the upper lip, lower lip, upper and lower lips, and shape of the Cupid's bow)...
September 1, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28381579/reverse-transcription-mechanically-initiates-hiv-1-capsid-disassembly
#18
Sanela Rankovic, Janani Varadarajan, Ruben Ramalho, Christopher Aiken, Itay Rousso
The HIV-1 core consists of the viral genomic RNA and several viral proteins encased within a conical capsid. After cell entry, the core disassembles in a process termed uncoating. Although HIV-1 uncoating has been linked to reverse transcription of the viral genome in target cells, the mechanism by which uncoating is initiated is unknown. Using time-lapse atomic force microscopy, we analyzed the morphology and physical properties of isolated HIV-1 cores during the course of reverse transcription in vitro We found that, during an early stage of reverse transcription the pressure inside the capsid increases, reaching a maximum after 7 h...
June 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28358765/introduction-of-the-american-academy-of-facial-plastic-and-reconstructive-surgery-face-to-face-database
#19
Manoj T Abraham, Joseph J Rousso, Shirley Hu, Ryan F Brown, Augustine L Moscatello, J Charles Finn, Neha A Patel, Sameep P Kadakia, Donald Wood-Smith
The American Academy of Facial Plastic and Reconstructive Surgery FACE TO FACE database was created to gather and organize patient data primarily from international humanitarian surgical mission trips, as well as local humanitarian initiatives. Similar to cloud-based Electronic Medical Records, this web-based user-generated database allows for more accurate tracking of provider and patient information and outcomes, regardless of site, and is useful when coordinating follow-up care for patients. The database is particularly useful on international mission trips as there are often different surgeons who may provide care to patients on subsequent missions, and patients who may visit more than 1 mission site...
March 29, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28346647/validation-of-olfactory-threshold-testing-methods
#20
Alan Hirsch, Alexander Roussos, Sally Freels
In patients with chemosensory complaints, a head-to-head comparison of unilateral olfaction threshold testing with the Phenyl Ethyl Alcohol Smell Threshold Test (PEA) and the OLFACT-RL Odor Threshold Test (OLFACT-RL) was undertaken. The charts of 23 consecutive patients presenting with chemosensory complaints seen at the Smell and Taste Treatment and Research Foundation were reviewed and information extracted per Institutional Review Board guidelines. All patients had undergone olfactory testing with the PEA test and the OLFACT-RL test in accordance with their published administration manuals...
March 2017: Ear, Nose, & Throat Journal
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