keyword
MENU ▼
Read by QxMD icon Read
search

roussos

keyword
https://www.readbyqxmd.com/read/29579179/a-bayesian-framework-for-multiple-trait-colo-calization-from-summary-association-statistics
#1
Claudia Giambartolomei, Jimmy Zhenli Liu, Wen Zhang, Mads Hauberg, Huwenbo Shi, James Boocock, Joe Pickrell, Andrew E Jaffe, Bogdan Pasaniuc, Panos Roussos
Motivation: Most genetic variants implicated in complex diseases by genome-wide association studies (GWAS) are non-coding, making it challenging to understand the causative genes involved in disease. Integrating external information such as quantitative trait locus (QTL) mapping of molecular traits (e.g., expression, methylation) is a powerful approach to identify the subset of GWAS signals explained by regulatory effects. In particular, expression QTLs (eQTLs) help pinpoint the responsible gene among the GWAS regions that harbor many genes, while methylation QTLs (mQTLs) help identify the epigenetic mechanisms that impact gene expression which in turn affect disease risk...
March 19, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29555295/multilocus-phylogeny-and-coalescent-species-delimitation-in-kotschy-s-gecko-mediodactylus-kotschyi-hidden-diversity-and-cryptic-species
#2
Panayiota Kotsakiozi, Daniel Jablonski, Çetin Ilgaz, Yusuf Kumlutaş, Aziz Avcı, Shai Meiri, Yuval Itescu, Oleg Kukushkin, Václav Gvoždík, Giovanni Scillitani, Stephen Roussos, David Jandzik, Panagiotis Kasapidis, Petros Lymberakis, Nikos Poulakakis
The Kotschy's Gecko, Mediodactylus kotschyi, is a small gecko native to southeastern Europe and the Eastern Mediterranean. It displays great morphological variation with a large number of morphologically recognized subspecies. However, it has been suggested that it constitutes a species complex of several yet unrecognized species. In this study, we used multilocus sequence data (three mitochondrial and three nuclear gene fragments) to estimate the phylogenetic relationships of 129 populations covering a substantial part of the distribution range of the species...
March 16, 2018: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29454512/frontal-and-temporal-cortical-volume-white-matter-tract-integrity-and-hemispheric-asymmetry-in-schizotypal-personality-disorder
#3
Chi C Chan, Philip R Szeszko, Edmund Wong, Cheuk Y Tang, Caitlin Kelliher, Justin D Penner, M Mercedes Perez-Rodriguez, Daniel R Rosell, Margaret McClure, Panos Roussos, Antonia S New, Larry J Siever, Erin A Hazlett
Abnormalities in temporal and frontal cortical volume, white matter tract integrity, and hemispheric asymmetry have been implicated in schizophrenia-spectrum disorders. Schizotypal personality disorder can provide insight into vulnerability and protective factors in these disorders without the confounds associated with chronic psychosis. However, multimodal imaging and asymmetry studies in SPD are sparse. Thirty-seven individuals with SPD and 29 healthy controls (HC) received clinical interviews and 3T magnetic resonance T1-weighted and diffusion tensor imaging scans...
February 14, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29450939/unexplained-infertility-patients-present-the-mostly-impaired-levels-of-progesterone-receptors-prospective-observational-study
#4
Stamatios Petousis, Yannis Prapas, Chrysoula Margioula-Siarkou, Konstantinos Ravanos, Stefanos Milias, George Mavromatidis, Ioannis Kalogiannidis, Costas Haitoglou, Apostolos Athanasiadis, Nikolaos Prapas, David Rousso
PROBLEM: Τo assess the endometrial expression of progesterone receptors in various subgroups of infertile women during implantation window. ΜETHODS: A prospective observational study was performed during March 2013-February 2017. Infertile women were categorized to those with tubal factor, ovarian failure, endometriosis or unexplained infertility. Endometrial biopsy was obtained on 7th-8th postovulatory day. Total progesterone receptors' PR(A + B) and type-B receptors' (PR-B) expression were compared between all categories of infertile and fruitful controls...
February 16, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29389974/olig2-and-hes-regulatory-dynamics-during-motor-neuron-differentiation-revealed-by-single-cell-transcriptomics
#5
Andreas Sagner, Zachary B Gaber, Julien Delile, Jennifer H Kong, David L Rousso, Caroline A Pearson, Steven E Weicksel, Manuela Melchionda, S Neda Mousavy Gharavy, James Briscoe, Bennett G Novitch
During tissue development, multipotent progenitors differentiate into specific cell types in characteristic spatial and temporal patterns. We addressed the mechanism linking progenitor identity and differentiation rate in the neural tube, where motor neuron (MN) progenitors differentiate more rapidly than other progenitors. Using single cell transcriptomics, we defined the transcriptional changes associated with the transition of neural progenitors into MNs. Reconstruction of gene expression dynamics from these data indicate a pivotal role for the MN determinant Olig2 just prior to MN differentiation...
February 2018: PLoS Biology
https://www.readbyqxmd.com/read/29367345/dimethyl-fumarate-potentiates-oncolytic-virotherapy-through-nf-%C3%AE%C2%BAb-inhibition
#6
Mohammed Selman, Paula Ou, Christopher Rousso, Anabel Bergeron, Ramya Krishnan, Larissa Pikor, Andrew Chen, Brian A Keller, Carolina Ilkow, John C Bell, Jean-Simon Diallo
Resistance to oncolytic virotherapy is frequently associated with failure of tumor cells to get infected by the virus. Dimethyl fumarate (DMF), a common treatment for psoriasis and multiple sclerosis, also has anticancer properties. We show that DMF and various fumaric and maleic acid esters (FMAEs) enhance viral infection of cancer cell lines as well as human tumor biopsies with several oncolytic viruses (OVs), improving therapeutic outcomes in resistant syngeneic and xenograft tumor models. This results in durable responses, even in models otherwise refractory to OV and drug monotherapies...
January 24, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29364720/testing-syndromes-of-psychopathology-in-parent-and-youth-ratings-across-societies
#7
Masha Y Ivanova, Thomas M Achenbach, Leslie A Rescorla, Jiesi Guo, Robert R Althoff, Kees-Jan Kan, Fredrik Almqvist, Ivan Begovac, Anders G Broberg, Myriam Chahed, Marina Monzani da Rocha, Anca Dobrean, Manfred Döepfner, Nese Erol, Eric Fombonne, Antonio Castro Fonseca, Maria Forns, Alessandra Frigerio, Hans Grietens, Nohelia Hewitt-Ramirez, Fernando Juarez, Ilona Kajokienė, Yasuko Kanbayashi, Young-Ah Kim, Bo Larsson, Patrick Leung, Xianchen Liu, Alfio Maggiolini, Asghar Minaei, Paulo A S Moreira, Kyung Ja Oh, Djaouida Petot, Cecilia Pisa, Rolando Pomalima, Alexandra Roussos, Vlasta Rudan, Michael Sawyer, Mimoza Shahini, Edwiges Ferreira de Mattos Silvares, Zeynep Simsek, Hans-Christoph Steinhausen, Lajos Szirovicza, Jose Valverde, Laura Viola, Sheila Weintraub, Christa Winkler Metzke, Tomasz Wolanczyk, Bernardine Woo, Eugene Yuqing Zhang, Nelly Zilber, Rita Žukauskienė, Frank C Verhulst
As societies become increasingly diverse, mental health professionals need instruments for assessing emotional, behavioral, and social problems in terms of constructs that are supported within and across societies. Building on decades of research findings, multisample alignment confirmatory factor analyses tested an empirically based 8-syndrome model on parent ratings across 30 societies and youth self-ratings across 19 societies. The Child Behavior Checklist for Ages 6-18 and Youth Self-Report for Ages 11-18 were used to measure syndromes descriptively designated as Anxious/Depressed, Withdrawn/Depressed, Somatic Complaints, Social Problems, Thought Problems, Attention Problems, Rule-Breaking Behavior, and Aggressive Behavior...
January 24, 2018: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/29289925/the-role-of-relationships-in-collaborative-partnership-success-lessons-from-the-alaska-fourth-r-project
#8
Claire V Crooks, Deinera Exner-Cortens, Wendi Siebold, Kami Moore, Lori Grassgreen, Patricia Owen, Ann Rausch, Mollie Rosier
Collaborative partnerships are critical to achieving health equity. As such, it is important to understand what contributes to the success of such partnerships. This paper describes the Alaska Fourth R collaborative, a multisectoral group of agencies (including education, health and human services, the violence against women sector, the governor's council on domestic violence, and an external evaluator) that successfully planned, implemented and evaluated a multi-focus health education program statewide. The purpose of this paper was to explore the ways in which seven pre-identified factors contributed to the successful achievement of the collaborative's goals...
April 2018: Evaluation and Program Planning
https://www.readbyqxmd.com/read/29287625/meta-analysis-on-the-association-between-genetic-polymorphisms-and-prepulse-inhibition-of-the-acoustic-startle-response
#9
Boris B Quednow, Kenechi Ejebe, Michael Wagner, Stella G Giakoumaki, Panos Bitsios, Veena Kumari, Panos Roussos
Sensorimotor gating measured by prepulse inhibition (PPI) of the acoustic startle response (ASR) has been proposed as one of the most promising electrophysiological endophenotypes of schizophrenia. During the past decade, a number of publications have reported significant associations between genetic polymorphisms and PPI in samples of schizophrenia patients and healthy volunteers. However, an overall evaluation of the robustness of these results has not been published so far. Therefore, we performed the first meta-analysis of published and unpublished associations between gene polymorphisms and PPI of ASR...
December 26, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29195252/aesthetic-nasal-reconstruction-principles-and-practice
#10
Joseph J Rousso
No abstract text is available yet for this article.
December 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/29186694/large-scale-cognitive-gwas-meta-analysis-reveals-tissue-specific-neural-expression-and-potential-nootropic-drug-targets
#11
Max Lam, Joey W Trampush, Jin Yu, Emma Knowles, Gail Davies, David C Liewald, John M Starr, Srdjan Djurovic, Ingrid Melle, Kjetil Sundet, Andrea Christoforou, Ivar Reinvang, Pamela DeRosse, Astri J Lundervold, Vidar M Steen, Thomas Espeseth, Katri Räikkönen, Elisabeth Widen, Aarno Palotie, Johan G Eriksson, Ina Giegling, Bettina Konte, Panos Roussos, Stella Giakoumaki, Katherine E Burdick, Antony Payton, William Ollier, Ornit Chiba-Falek, Deborah K Attix, Anna C Need, Elizabeth T Cirulli, Aristotle N Voineskos, Nikos C Stefanis, Dimitrios Avramopoulos, Alex Hatzimanolis, Dan E Arking, Nikolaos Smyrnis, Robert M Bilder, Nelson A Freimer, Tyrone D Cannon, Edythe London, Russell A Poldrack, Fred W Sabb, Eliza Congdon, Emily Drabant Conley, Matthew A Scult, Dwight Dickinson, Richard E Straub, Gary Donohoe, Derek Morris, Aiden Corvin, Michael Gill, Ahmad R Hariri, Daniel R Weinberger, Neil Pendleton, Panos Bitsios, Dan Rujescu, Jari Lahti, Stephanie Le Hellard, Matthew C Keller, Ole A Andreassen, Ian J Deary, David C Glahn, Anil K Malhotra, Todd Lencz
Here, we present a large (n = 107,207) genome-wide association study (GWAS) of general cognitive ability ("g"), further enhanced by combining results with a large-scale GWAS of educational attainment. We identified 70 independent genomic loci associated with general cognitive ability. Results showed significant enrichment for genes causing Mendelian disorders with an intellectual disability phenotype. Competitive pathway analysis implicated the biological processes of neurogenesis and synaptic regulation, as well as the gene targets of two pharmacologic agents: cinnarizine, a T-type calcium channel blocker, and LY97241, a potassium channel inhibitor...
November 28, 2017: Cell Reports
https://www.readbyqxmd.com/read/29175158/multi-modal-potentiation-of-oncolytic-virotherapy-by-vanadium-compounds
#12
Mohammed Selman, Christopher Rousso, Anabel Bergeron, Hwan Hee Son, Ramya Krishnan, Nader A El-Sayes, Oliver Varette, Andrew Chen, Fabrice Le Boeuf, Fanny Tzelepis, John C Bell, Debbie C Crans, Jean-Simon Diallo
Oncolytic viruses (OV) are an emerging class of anticancer bio-therapeutics that induce antitumor immunity through selective replication in tumor cells. However, the efficacy of OVs as single agents remains limited. We introduce a strategy that boosts the therapeutic efficacy of OVs by combining their activity with immuno-modulating, small molecule protein tyrosine phosphatase inhibitors. We report that vanadium-based phosphatase inhibitors enhance OV infection in vitro and ex vivo, in resistant tumor cell lines...
January 3, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29164265/the-power-and-pitfalls-of-big-data-research-in-obstetrics-and-gynecology-a-consumer-s-guide
#13
Amie Goodin, Chris Delcher, Chelsea Valenzuela, Xi Wang, Yanmin Zhu, Dikea Roussos-Ross, Joshua D Brown
Importance: Research in obstetrics and gynecology (OB/GYN) increasingly relies on "big data" and observational study designs. There is a gap in practitioner-relevant guides to interpret and critique such research. Objective: This guide is an introduction to interpreting research using observational data and provides explanations and context for related terminology. In addition, it serves as a guide for critiquing OB/GYN studies that use observational data by outlining how to assess common pitfalls of experimental and observational study designs...
November 2017: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/29151190/elucidation-of-functional-chemical-groups-responsible-of-compost-phytotoxicity-using-solid-state-13-c-nmr-spectroscopy-under-different-initial-c-n-ratios
#14
Khalid Azim, Youssef Faissal, Brahim Soudi, Claude Perissol, Sevastianos Roussos, Imane Thami Alami
More than 1 million tons of fresh organic wastes is produced in the Souss-Massa region in Morocco. Tomato organic residues represent more than 25% of the total organic wastes and are deposited in uncontrolled landfills. Thus, composting can represent a valuable and pertinent solution to this environmental problem. The objectives of this experiment are to identify the potential functional groups responsible for compost phytotoxicity and to determine the optimum initial carbon to nitrogen ratio (C/N) for maximum recovery of tomato residues...
November 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29110447/evidence-based-position-paper-on-physical-and-rehabilitation-medicine-prm-professional-practice-for-ageing-people-with-disabilities-the-european-prm-position-uems-prm-section
#15
Aydan Oral, Christina-Anastasia Rapidi, Jiri Votava, Nikolaos Roussos, Xanthi Michail, Jolanta Kujawa, Stefano Negrini, Enrique Varela Donoso, Nicolas Christodoulou
Ageing people with disabilities (APwDs) are faced with challenges of ageing which is straightforwardly related to disability that adds to the burden related to their early-onset disability. The aim of the paper is to improve Physical and Rehabilitation Medicine (PRM) physicians' professional practice for APwDs (as a distinct group from those who are disabled due to the ageing process) in order to promote their functioning properties and to reduce activity limitations and/or participation restrictions. A systematic review of the literature and a Consensus procedure by means of a Delphi process have been performed involving the delegates of all European countries represented in the UEMS PRM Section...
October 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29096131/winter-birth-urbanicity-and-immigrant-status-predict-psychometric-schizotypy-dimensions-in-adolescents
#16
D Mimarakis, T Roumeliotaki, P Roussos, S G Giakoumaki, P Bitsios
BACKGROUND: Urbanicity, immigration and winter-birth are stable epidemiological risk factors for schizophrenia, but their relationship to schizotypy is unknown. This is a first examination of the association of these epidemiological risk factors with positive schizotypy, in nonclinical adolescents, controlling for a range of potential and known confounders. METHODS: We collected socio-demographics, life-style, family and school circumstances, positive schizotypy dimensions and other personality traits from 445 high school pupils (192 males, 158 immigrants) from 9 municipalities in Athens and Heraklion, Greece, which covered a range of host population and migrant densities...
January 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29068436/gwas-meta-analysis-reveals-novel-loci-and-genetic-correlates-for-general-cognitive-function-a-report-from-the-cogent-consortium
#17
J W Trampush, M L Z Yang, J Yu, E Knowles, G Davies, D C Liewald, J M Starr, S Djurovic, I Melle, K Sundet, A Christoforou, I Reinvang, P DeRosse, A J Lundervold, V M Steen, T Espeseth, K Räikkönen, E Widen, A Palotie, J G Eriksson, I Giegling, B Konte, P Roussos, S Giakoumaki, K E Burdick, A Payton, W Ollier, M Horan, O Chiba-Falek, D K Attix, A C Need, E T Cirulli, A N Voineskos, N C Stefanis, D Avramopoulos, A Hatzimanolis, D E Arking, N Smyrnis, R M Bilder, N A Freimer, T D Cannon, E London, R A Poldrack, F W Sabb, E Congdon, E D Conley, M A Scult, D Dickinson, R E Straub, G Donohoe, D Morris, A Corvin, M Gill, A R Hariri, D R Weinberger, N Pendleton, P Bitsios, D Rujescu, J Lahti, S Le Hellard, M C Keller, O A Andreassen, I J Deary, D C Glahn, A K Malhotra, T Lencz
This corrects the article DOI: 10.1038/mp.2016.244.
November 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29068182/obesity-and-reproduction-a-study-to-determine-how-effectively-medical-education-enhances-awareness-of-the-reproductive-risks-related-to-obesity
#18
Alice S Rhoton-Vlasak, Kay Roussos-Ross, Girard M Cua, Erica L Odera, Tracy A Irani, Terrie Vasilopoulos
OBJECTIVE: To explore awareness of the reproductive versus the medical risks of obesity in a medical and non-medical college educated population. METHODS: An exploratory prospective research design was used. A 26-question online survey was developed and offered to a sample of medical students/residents (n=325) and non-medical college students (n=102). The data were analyzed using Graph Pad software. RESULTS: 102 non-medical undergraduate students (28% male and 72% female) and 325 resident physicians and medical students (46% male, 47% female, 7% unspecified) responded...
December 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/29036523/stress-dependent-association-between-polygenic-risk-for-schizophrenia-and-schizotypal-traits-in-young-army-recruits
#19
Alex Hatzimanolis, Dimitrios Avramopoulos, Dan E Arking, Anna Moes, Pallav Bhatnagar, Todd Lencz, Anil K Malhotra, Stella G Giakoumaki, Panos Roussos, Nikolaos Smyrnis, Panos Bitsios, Nicholas C Stefanis
Schizotypal personality traits may increase proneness to psychosis and likely index familial vulnerability to schizophrenia (SZ), implying shared genetic determinants with SZ. Here, we sought to investigate the contribution of common genetic risk variation for SZ on self-reported schizotypy in 2 ethnically homogeneous cohorts of healthy young males during compulsory military service, enrolled in the Athens Study of Proneness and Incidence of Schizophrenia (ASPIS, N = 875) and the Learning on Genetics of Schizophrenia Spectrum study (LOGOS, N = 690)...
June 13, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28959355/selective-isolation-and-screening-of-actinobacteria-strains-producing-lignocellulolytic-enzymes-using-olive-pomace-as-substrate
#20
Lamia Medouni-Haroune, Farid Zaidi, Sonia Medouni-Adrar, Sevastianos Roussos, Samia Azzouz, Véronique Desseaux, Mouloud Kecha
BACKGROUND: Olive pomace, as the main by-product of the olive oil industry, is recently recycled as fermentation substrate for enzyme production. OBJECTIVES: Actinobacteria isolates were separated from an Algerian soil under olive pomace cultivation and were evaluated for their lignocellulolytic enzymes production. MATERIALS AND METHODS: Isolates of Actinobacteria were separated from soils around oil mills using four isolation media, among them three were enriched by olive pomace...
March 2017: Iranian Journal of Biotechnology
keyword
keyword
52753
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"