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https://www.readbyqxmd.com/read/29195252/aesthetic-nasal-reconstruction-principles-and-practice
#1
Joseph J Rousso
No abstract text is available yet for this article.
December 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/29186694/large-scale-cognitive-gwas-meta-analysis-reveals-tissue-specific-neural-expression-and-potential-nootropic-drug-targets
#2
Max Lam, Joey W Trampush, Jin Yu, Emma Knowles, Gail Davies, David C Liewald, John M Starr, Srdjan Djurovic, Ingrid Melle, Kjetil Sundet, Andrea Christoforou, Ivar Reinvang, Pamela DeRosse, Astri J Lundervold, Vidar M Steen, Thomas Espeseth, Katri Räikkönen, Elisabeth Widen, Aarno Palotie, Johan G Eriksson, Ina Giegling, Bettina Konte, Panos Roussos, Stella Giakoumaki, Katherine E Burdick, Antony Payton, William Ollier, Ornit Chiba-Falek, Deborah K Attix, Anna C Need, Elizabeth T Cirulli, Aristotle N Voineskos, Nikos C Stefanis, Dimitrios Avramopoulos, Alex Hatzimanolis, Dan E Arking, Nikolaos Smyrnis, Robert M Bilder, Nelson A Freimer, Tyrone D Cannon, Edythe London, Russell A Poldrack, Fred W Sabb, Eliza Congdon, Emily Drabant Conley, Matthew A Scult, Dwight Dickinson, Richard E Straub, Gary Donohoe, Derek Morris, Aiden Corvin, Michael Gill, Ahmad R Hariri, Daniel R Weinberger, Neil Pendleton, Panos Bitsios, Dan Rujescu, Jari Lahti, Stephanie Le Hellard, Matthew C Keller, Ole A Andreassen, Ian J Deary, David C Glahn, Anil K Malhotra, Todd Lencz
Here, we present a large (n = 107,207) genome-wide association study (GWAS) of general cognitive ability ("g"), further enhanced by combining results with a large-scale GWAS of educational attainment. We identified 70 independent genomic loci associated with general cognitive ability. Results showed significant enrichment for genes causing Mendelian disorders with an intellectual disability phenotype. Competitive pathway analysis implicated the biological processes of neurogenesis and synaptic regulation, as well as the gene targets of two pharmacologic agents: cinnarizine, a T-type calcium channel blocker, and LY97241, a potassium channel inhibitor...
November 28, 2017: Cell Reports
https://www.readbyqxmd.com/read/29175158/multi-modal-potentiation-of-oncolytic-virotherapy-by-vanadium-compounds
#3
Mohammed Selman, Christopher Rousso, Anabel Bergeron, Hwan Hee Son, Ramya Krishnan, Nader A El-Sayes, Oliver Varette, Andrew Chen, Fabrice Le Boeuf, Fanny Tzelepis, John C Bell, Debbie C Crans, Jean-Simon Diallo
Oncolytic viruses (OV) are an emerging class of anticancer bio-therapeutics that induce antitumor immunity through selective replication in tumor cells. However, the efficacy of OVs as single agents remains limited. We introduce a strategy that boosts the therapeutic efficacy of OVs by combining their activity with immuno-modulating, small molecule protein tyrosine phosphatase inhibitors. We report that vanadium-based phosphatase inhibitors enhance OV infection in vitro and ex vivo, in resistant tumor cell lines...
October 24, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29164265/the-power-and-pitfalls-of-big-data-research-in-obstetrics-and-gynecology-a-consumer-s-guide
#4
Amie Goodin, Chris Delcher, Chelsea Valenzuela, Xi Wang, Yanmin Zhu, Dikea Roussos-Ross, Joshua D Brown
Importance: Research in obstetrics and gynecology (OB/GYN) increasingly relies on "big data" and observational study designs. There is a gap in practitioner-relevant guides to interpret and critique such research. Objective: This guide is an introduction to interpreting research using observational data and provides explanations and context for related terminology. In addition, it serves as a guide for critiquing OB/GYN studies that use observational data by outlining how to assess common pitfalls of experimental and observational study designs...
November 2017: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/29151190/elucidation-of-functional-chemical-groups-responsible-of-compost-phytotoxicity-using-solid-state-13-c-nmr-spectroscopy-under-different-initial-c-n-ratios
#5
Khalid Azim, Youssef Faissal, Brahim Soudi, Claude Perissol, Sevastianos Roussos, Imane Thami Alami
More than 1 million tons of fresh organic wastes is produced in the Souss-Massa region in Morocco. Tomato organic residues represent more than 25% of the total organic wastes and are deposited in uncontrolled landfills. Thus, composting can represent a valuable and pertinent solution to this environmental problem. The objectives of this experiment are to identify the potential functional groups responsible for compost phytotoxicity and to determine the optimum initial carbon to nitrogen ratio (C/N) for maximum recovery of tomato residues...
November 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29110447/evidence-based-position-paper-on-physical-and-rehabilitation-medicine-prm-professional-practice-for-ageing-people-with-disabilities-the-european-prm-position-uems-prm-section
#6
Aydan Oral, Christina-Anastasia Rapidi, Jiri Votava, Nikolaos Roussos, Xanthi Michail, Jolanta Kujawa, Stefano Negrini, Enrique Varela Donoso, Nicolas Christodoulou
Ageing people with disabilities (APwDs) are faced with challenges of ageing which is straightforwardly related to disability that adds to the burden related to their early-onset disability. The aim of the paper is to improve Physical and Rehabilitation Medicine (PRM) physicians' professional practice for APwDs (as a distinct group from those who are disabled due to the ageing process) in order to promote their functioning properties and to reduce activity limitations and/or participation restrictions. A systematic review of the literature and a Consensus procedure by means of a Delphi process have been performed involving the delegates of all European countries represented in the UEMS PRM Section...
October 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29096131/winter-birth-urbanicity-and-immigrant-status-predict-psychometric-schizotypy-dimensions-in-adolescents
#7
D Mimarakis, T Roumeliotaki, P Roussos, S G Giakoumaki, P Bitsios
BACKGROUND: Urbanicity, immigration and winter-birth are stable epidemiological risk factors for schizophrenia, but their relationship to schizotypy is unknown. This is a first examination of the association of these epidemiological risk factors with positive schizotypy, in nonclinical adolescents, controlling for a range of potential and known confounders. METHODS: We collected socio-demographics, life-style, family and school circumstances, positive schizotypy dimensions and other personality traits from 445 high school pupils (192 males, 158 immigrants) from 9 municipalities in Athens and Heraklion, Greece, which covered a range of host population and migrant densities...
September 18, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29068436/gwas-meta-analysis-reveals-novel-loci-and-genetic-correlates-for-general-cognitive-function-a-report-from-the-cogent-consortium
#8
J W Trampush, M L Z Yang, J Yu, E Knowles, G Davies, D C Liewald, J M Starr, S Djurovic, I Melle, K Sundet, A Christoforou, I Reinvang, P DeRosse, A J Lundervold, V M Steen, T Espeseth, K Räikkönen, E Widen, A Palotie, J G Eriksson, I Giegling, B Konte, P Roussos, S Giakoumaki, K E Burdick, A Payton, W Ollier, M Horan, O Chiba-Falek, D K Attix, A C Need, E T Cirulli, A N Voineskos, N C Stefanis, D Avramopoulos, A Hatzimanolis, D E Arking, N Smyrnis, R M Bilder, N A Freimer, T D Cannon, E London, R A Poldrack, F W Sabb, E Congdon, E D Conley, M A Scult, D Dickinson, R E Straub, G Donohoe, D Morris, A Corvin, M Gill, A R Hariri, D R Weinberger, N Pendleton, P Bitsios, D Rujescu, J Lahti, S Le Hellard, M C Keller, O A Andreassen, I J Deary, D C Glahn, A K Malhotra, T Lencz
This corrects the article DOI: 10.1038/mp.2016.244.
November 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29068182/obesity-and-reproduction-a-study-to-determine-how-effectively-medical-education-enhances-awareness-of-the-reproductive-risks-related-to-obesity
#9
Alice S Rhoton-Vlasak, Kay Roussos-Ross, Girard M Cua, Erica L Odera, Tracy A Irani, Terrie Vasilopoulos
OBJECTIVE: To explore awareness of the reproductive versus the medical risks of obesity in a medical and non-medical college educated population. METHODS: An exploratory prospective research design was used. A 26-question online survey was developed and offered to a sample of medical students/residents (n=325) and non-medical college students (n=102). The data were analyzed using Graph Pad software. RESULTS: 102 non-medical undergraduate students (28% male and 72% female) and 325 resident physicians and medical students (46% male, 47% female, 7% unspecified) responded...
October 25, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/29036523/stress-dependent-association-between-polygenic-risk-for-schizophrenia-and-schizotypal-traits-in-young-army-recruits
#10
Alex Hatzimanolis, Dimitrios Avramopoulos, Dan E Arking, Anna Moes, Pallav Bhatnagar, Todd Lencz, Anil K Malhotra, Stella G Giakoumaki, Panos Roussos, Nikolaos Smyrnis, Panos Bitsios, Nicholas C Stefanis
Schizotypal personality traits may increase proneness to psychosis and likely index familial vulnerability to schizophrenia (SZ), implying shared genetic determinants with SZ. Here, we sought to investigate the contribution of common genetic risk variation for SZ on self-reported schizotypy in 2 ethnically homogeneous cohorts of healthy young males during compulsory military service, enrolled in the Athens Study of Proneness and Incidence of Schizophrenia (ASPIS, N = 875) and the Learning on Genetics of Schizophrenia Spectrum study (LOGOS, N = 690)...
June 13, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28959355/selective-isolation-and-screening-of-actinobacteria-strains-producing-lignocellulolytic-enzymes-using-olive-pomace-as-substrate
#11
Lamia Medouni-Haroune, Farid Zaidi, Sonia Medouni-Adrar, Sevastianos Roussos, Samia Azzouz, Véronique Desseaux, Mouloud Kecha
BACKGROUND: Olive pomace, as the main by-product of the olive oil industry, is recently recycled as fermentation substrate for enzyme production. OBJECTIVES: Actinobacteria isolates were separated from an Algerian soil under olive pomace cultivation and were evaluated for their lignocellulolytic enzymes production. MATERIALS AND METHODS: Isolates of Actinobacteria were separated from soils around oil mills using four isolation media, among them three were enriched by olive pomace...
March 2017: Iranian Journal of Biotechnology
https://www.readbyqxmd.com/read/28931188/congenital-ear-malformations-effectively-correcting-cryptotia-with-neonatal-ear-molding
#12
Collin Rozanski, Joseph J Rousso
No abstract text is available yet for this article.
September 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28892060/a-functional-genomics-predictive-network-model-identifies-regulators-of-inflammatory-bowel-disease
#13
Lauren A Peters, Jacqueline Perrigoue, Arthur Mortha, Alina Iuga, Won-Min Song, Eric M Neiman, Sean R Llewellyn, Antonio Di Narzo, Brian A Kidd, Shannon E Telesco, Yongzhong Zhao, Aleksandar Stojmirovic, Jocelyn Sendecki, Khader Shameer, Riccardo Miotto, Bojan Losic, Hardik Shah, Eunjee Lee, Minghui Wang, Jeremiah J Faith, Andrew Kasarskis, Carrie Brodmerkel, Mark Curran, Anuk Das, Joshua R Friedman, Yoshinori Fukui, Mary Beth Humphrey, Brian M Iritani, Nicholas Sibinga, Teresa K Tarrant, Carmen Argmann, Ke Hao, Panos Roussos, Jun Zhu, Bin Zhang, Radu Dobrin, Lloyd F Mayer, Eric E Schadt
A major challenge in inflammatory bowel disease (IBD) is the integration of diverse IBD data sets to construct predictive models of IBD. We present a predictive model of the immune component of IBD that informs causal relationships among loci previously linked to IBD through genome-wide association studies (GWAS) using functional and regulatory annotations that relate to the cells, tissues, and pathophysiology of IBD. Our model consists of individual networks constructed using molecular data generated from intestinal samples isolated from three populations of patients with IBD at different stages of disease...
October 2017: Nature Genetics
https://www.readbyqxmd.com/read/28782404/does-first-trimester-nuchal-cord-affect-the-blood-flow-in-the-ductus-venosus-a-prospective-observational-study
#14
S Petousis, C Margioula-Siarkou, A Mamopoulos, A Sotiriadis, D Rousso, A Athanasiadis, T Dagklis
INTRODUCTION: Main objective of the present study was to investigate the association between the presence of nuchal cord (NC) and the measurement of the ductus venosus pulsatility index for veins (ductus venosus (DV) PIV). METHODS: This was a prospective study of 1974 singleton pregnancies that underwent first-trimester screening at 11-13(+6) gestational weeks. Color Doppler was used to demonstrate the presence of a NC in all cases and the DV PIV was calculated routinely, as part of the standard scan...
August 16, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28758885/dimensional-traits-of-schizotypy-associated-with-glycine-receptor-glra1-polymorphism-an-exploratory-candidate-gene-association-study
#15
Anvi K Vora, Amanda M Fisher, Antonia S New, Erin A Hazlett, Margaret McNamara, Qiaoping Yuan, Zhifeng Zhou, Colin Hodgkinson, David Goldman, Larry J Siever, Panos Roussos, M Mercedes Perez-Rodriguez
Schizotypy captures the underlying genetic vulnerability to schizophrenia. However, the genetic underpinnings of schizotypy remain unexplored. The authors examined the relationship between single nucleotide polymorphisms (SNPs) and schizotypy. A sample of 137 subjects (43 healthy controls, 34 subjects with schizotypal personality disorder [SPD], 32 with borderline personality disorder, and 25 with other personality disorders) completed the Schizotypal Personality Questionnaire (SPQ). Subjects were genotyped using a custom array chip...
July 31, 2017: Journal of Personality Disorders
https://www.readbyqxmd.com/read/28753612/four-alpha-ganglion-cell-types-in-mouse-retina-function-structure-and-molecular-signatures
#16
Brenna Krieger, Mu Qiao, David L Rousso, Joshua R Sanes, Markus Meister
The retina communicates with the brain using ≥30 parallel channels, each carried by axons of distinct types of retinal ganglion cells. In every mammalian retina one finds so-called "alpha" ganglion cells (αRGCs), identified by their large cell bodies, stout axons, wide and mono-stratified dendritic fields, and high levels of neurofilament protein. In the mouse, three αRGC types have been described based on responses to light steps: On-sustained, Off-sustained, and Off-transient. Here we employed a transgenic mouse line that labels αRGCs in the live retina, allowing systematic targeted recordings...
2017: PloS One
https://www.readbyqxmd.com/read/28686855/large-scale-identification-of-common-trait-and-disease-variants-affecting-gene-expression
#17
Mads Engel Hauberg, Wen Zhang, Claudia Giambartolomei, Oscar Franzén, David L Morris, Timothy J Vyse, Arno Ruusalepp, Pamela Sklar, Eric E Schadt, Johan L M Björkegren, Panos Roussos
No abstract text is available yet for this article.
July 6, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28685207/clinical-effects-of-long-term-cardiac-contractility-modulation-ccm-in-subjects-with-heart-failure-caused-by-left-ventricular-systolic-dysfunction
#18
D Müller, A Remppis, P Schauerte, S Schmidt-Schweda, D Burkhoff, B Rousso, D Gutterman, J Senges, G Hindricks, K-H Kuck
INTRODUCTION: Heart failure is a major cause of morbidity and mortality throughout the world. Despite advances in therapy, nearly half of patients receiving guideline-directed medical therapy remain limited by symptoms. Cardiac contractility modulation (CCM) can improve symptoms in this population, but efficacy and safety in prospective studies has been limited to 12 months of follow-up. We report on the first 2 year multi-site evaluation of CCM in patients with heart failure. METHODS: One hundred and forty-three subjects with heart failure and reduced ejection fraction were followed via clinical registry for 24 months recording NYHA class, MLWHFQ score, 6 min walk distance, LVEF, and peak VO2 at baseline and 6 month intervals as clinically indicated...
November 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28671686/the-methyltransferase-setdb1-regulates-a-large-neuron-specific-topological-chromatin-domain
#19
Yan Jiang, Yong-Hwee Eddie Loh, Prashanth Rajarajan, Teruyoshi Hirayama, Will Liao, Bibi S Kassim, Behnam Javidfar, Brigham J Hartley, Lisa Kleofas, Royce B Park, Benoit Labonte, Seok-Man Ho, Sandhya Chandrasekaran, Catherine Do, Brianna R Ramirez, Cyril J Peter, Julia T C W, Brian M Safaie, Hirofumi Morishita, Panos Roussos, Eric J Nestler, Anne Schaefer, Benjamin Tycko, Kristen J Brennand, Takeshi Yagi, Li Shen, Schahram Akbarian
We report locus-specific disintegration of megabase-scale chromosomal conformations in brain after neuronal ablation of Setdb1 (also known as Kmt1e; encodes a histone H3 lysine 9 methyltransferase), including a large topologically associated 1.2-Mb domain conserved in humans and mice that encompasses >70 genes at the clustered protocadherin locus (hereafter referred to as cPcdh). The cPcdh topologically associated domain (TAD(cPcdh)) in neurons from mutant mice showed abnormal accumulation of the transcriptional regulator and three-dimensional (3D) genome organizer CTCF at cryptic binding sites, in conjunction with DNA cytosine hypomethylation, histone hyperacetylation and upregulated expression...
August 2017: Nature Genetics
https://www.readbyqxmd.com/read/28552197/large-scale-identification-of-common-trait-and-disease-variants-affecting-gene-expression
#20
Mads Engel Hauberg, Wen Zhang, Claudia Giambartolomei, Oscar Franzén, David L Morris, Timothy J Vyse, Arno Ruusalepp, Pamela Sklar, Eric E Schadt, Johan L M Björkegren, Panos Roussos
Genome-wide association studies (GWASs) have identified a multitude of genetic loci involved with traits and diseases. However, it is often unclear which genes are affected in such loci and whether the associated genetic variants lead to increased or decreased gene function. To mitigate this, we integrated associations of common genetic variants in 57 GWASs with 24 studies of expression quantitative trait loci (eQTLs) from a broad range of tissues by using a Mendelian randomization approach. We discovered a total of 3,484 instances of gene-trait-associated changes in expression at a false-discovery rate < 0...
June 1, 2017: American Journal of Human Genetics
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