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https://www.readbyqxmd.com/read/28225373/outer-retinal-tubulation-a-case-series
#1
Leticia A Rousso, Julie A Rodman, Brad Sutton, Diana L Shechtman
PURPOSE: The advent of spectral domain optical coherence tomography has led to superb imaging capabilities in addition to enhanced visualization of the retinal layers. Such advancements have led to the identification of a variety of new retinal conditions, including outer retinal tubulations (ORTs). ORTs are ovoid hyporeflective spaces located in the outer retina. The pathogenesis is unclear but seems to involve sublethal injury to the photoreceptors leading to a compensatory reorganization of the photoreceptor layer with the neighboring ellipsoid zone resulting in a hyperreflective border surrounding a central lumen...
March 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28187594/nuclear-markers-support-the-mitochondrial-phylogeny-of-i-vipera-i-i-ursinii-renardi-i-complex-squamata-viperidae-and-species-status-for-the-greek-meadow-viper
#2
Edvárd Mizsei, Daniel Jablonski, Stephanos A Roussos, Maria Dimaki, Yannis Ioannidis, Göran Nilson, Zoltán T Nagy
Meadow vipers (Vipera ursinii-renardi complex) are small-bodied snakes that live in either lowland grasslands or montane subalpine-alpine meadows spanning a distribution from France to western China. This complex has previously been the focus of several taxonomic studies which were based mainly on morphological, allozyme or immunological characters and did not clearly resolve the relationships between the various taxa. Recent mitochondrial DNA analyses found unexpected relationships within the complex which had taxonomical consequences for the detected lineages...
January 31, 2017: Zootaxa
https://www.readbyqxmd.com/read/28109942/effect-of-pulmonary-rehabilitation-on-tidal-expiratory-flow-limitation-at-rest-and-during-exercise-in-copd-patients
#3
Elpida P Theodorakopoulou, Sofia-Antiopi Gennimata, Maria Harikiopoulou, Georgios Kaltsakas, Anastasios Palamidas, Antonia Koutsoukou, Charis Roussos, Epameinondas N Kosmas, Petros Bakakos, Nickolaos G Koulouris
We hypothesized that severe COPD patients who present with the disadvantageous phenomenon of Expiratory Flow Limitation (EFL) may benefit as COPD patients without EFL do after implementation of a Pulmonary Rehabilitation (PR) program. Forty-two stable COPD patients were studied at rest and during exercise. EFL and dynamic hyperinflation (DH) were documented using the negative expiratory pressure (NEP) technique and inspiratory capacity (IC) maneuvers, respectively. Patient centered outcomes were evaluated by the Saint-George's Respiratory Questionnaire (SGRQ) and the mMRC dyspnea scale...
January 18, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28108212/do-educational-seminars-for-the-human-papillomavirus-vaccine-improve-attitudes-toward-the-value-of-vaccination
#4
Kay Roussos-Ross, L Foster, H V Peterson, Julie Decesare
STUDY OBJECTIVE: This study aimed to determine the effectiveness and impact of educational seminars given at two sites in North-Central Florida on the knowledge of human papillomavirus (HPV), perceived barriers to HPV vaccination, and willingness to vaccinate against HPV in eligible patients. DESIGN, SETTING, AND PARTICIPANTS: This study was performed in conjunction with the Committee for the Healthcare of Underserved Women, District XII, American College of Obstetrics and Gynecology (ACOG)...
January 17, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28105383/a-3d-contact-analysis-approach-for-the-visualization-of-the-electrical-contact-asperities
#5
Constantinos C Roussos, Jonathan Swingler
The electrical contact is an important phenomenon that should be given into consideration to achieve better performance and long term reliability for the design of devices. Based upon this importance, the electrical contact interface has been visualized as a ''3D Contact Map'' and used in order to investigate the contact asperities. The contact asperities describe the structures above and below the contact spots (the contact spots define the 3D contact map) to the two conductors which make the contact system...
January 2017: AIP Advances
https://www.readbyqxmd.com/read/28093568/gwas-meta-analysis-reveals-novel-loci-and-genetic-correlates-for-general-cognitive-function-a-report-from-the-cogent-consortium
#6
J W Trampush, M L Z Yang, J Yu, E Knowles, G Davies, D C Liewald, J M Starr, S Djurovic, I Melle, K Sundet, A Christoforou, I Reinvang, P DeRosse, A J Lundervold, V M Steen, T Espeseth, K Räikkönen, E Widen, A Palotie, J G Eriksson, I Giegling, B Konte, P Roussos, S Giakoumaki, K E Burdick, A Payton, W Ollier, M Horan, O Chiba-Falek, D K Attix, A C Need, E T Cirulli, A N Voineskos, N C Stefanis, D Avramopoulos, A Hatzimanolis, D E Arking, N Smyrnis, R M Bilder, N A Freimer, T D Cannon, E London, R A Poldrack, F W Sabb, E Congdon, E D Conley, M A Scult, D Dickinson, R E Straub, G Donohoe, D Morris, A Corvin, M Gill, A R Hariri, D R Weinberger, N Pendleton, P Bitsios, D Rujescu, J Lahti, S Le Hellard, M C Keller, O A Andreassen, I J Deary, D C Glahn, A K Malhotra, T Lencz
The complex nature of human cognition has resulted in cognitive genomics lagging behind many other fields in terms of gene discovery using genome-wide association study (GWAS) methods. In an attempt to overcome these barriers, the current study utilized GWAS meta-analysis to examine the association of common genetic variation (~8M single-nucleotide polymorphisms (SNP) with minor allele frequency ⩾1%) to general cognitive function in a sample of 35 298 healthy individuals of European ancestry across 24 cohorts in the Cognitive Genomics Consortium (COGENT)...
March 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28072414/evidence-for-genetic-heterogeneity-between-clinical-subtypes-of-bipolar-disorder
#7
A W Charney, D M Ruderfer, E A Stahl, J L Moran, K Chambert, R A Belliveau, L Forty, K Gordon-Smith, A Di Florio, P H Lee, E J Bromet, P F Buckley, M A Escamilla, A H Fanous, L J Fochtmann, D S Lehrer, D Malaspina, S R Marder, C P Morley, H Nicolini, D O Perkins, J J Rakofsky, M H Rapaport, H Medeiros, J L Sobell, E K Green, L Backlund, S E Bergen, A Juréus, M Schalling, P Lichtenstein, P Roussos, J A Knowles, I Jones, L A Jones, C M Hultman, R H Perlis, S M Purcell, S A McCarroll, C N Pato, M T Pato, N Craddock, M Landén, J W Smoller, P Sklar
We performed a genome-wide association study of 6447 bipolar disorder (BD) cases and 12 639 controls from the International Cohort Collection for Bipolar Disorder (ICCBD). Meta-analysis was performed with prior results from the Psychiatric Genomics Consortium Bipolar Disorder Working Group for a combined sample of 13 902 cases and 19 279 controls. We identified eight genome-wide significant, associated regions, including a novel associated region on chromosome 10 (rs10884920; P=3.28 × 10(-8)) that includes the brain-enriched cytoskeleton protein adducin 3 (ADD3), a non-coding RNA, and a neuropeptide-specific aminopeptidase P (XPNPEP1)...
January 10, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28017796/analysis-of-transcriptional-variability-in-a-large-human-ipsc-library-reveals-genetic-and-non-genetic-determinants-of-heterogeneity
#8
Ivan Carcamo-Orive, Gabriel E Hoffman, Paige Cundiff, Noam D Beckmann, Sunita L D'Souza, Joshua W Knowles, Achchhe Patel, Dimitri Papatsenko, Fahim Abbasi, Gerald M Reaven, Sean Whalen, Philip Lee, Mohammad Shahbazi, Marc Y R Henrion, Kuixi Zhu, Sven Wang, Panos Roussos, Eric E Schadt, Gaurav Pandey, Rui Chang, Thomas Quertermous, Ihor Lemischka
Variability in induced pluripotent stem cell (iPSC) lines remains a concern for disease modeling and regenerative medicine. We have used RNA-sequencing analysis and linear mixed models to examine the sources of gene expression variability in 317 human iPSC lines from 101 individuals. We found that ∼50% of genome-wide expression variability is explained by variation across individuals and identified a set of expression quantitative trait loci that contribute to this variation. These analyses coupled with allele-specific expression show that iPSCs retain a donor-specific gene expression pattern...
December 2, 2016: Cell Stem Cell
https://www.readbyqxmd.com/read/27983748/-for-me-it-was-a-key-moment-of-therapy-corrective-experience-from-the-client-s-perspective
#9
Andrés Roussos, Malena Braun, Julieta Olivera
Despite recent attempts to develop a consensus definition, questions still remain as to what constitutes corrective experiences (CEs) in psychotherapy and how clients perceive them. This qualitative study assessed clients' first person accounts of CEs associated with their own treatment-related changes. Participants were 8 clients in private psychotherapy in Buenos Aires. Treatment, by therapists from diverse theoretical backgrounds, varied from 4 to 24 months. The Patients' Perceptions of Corrective Experiences in Individual Therapy interview protocol was used to assess clients' perceptions of CEs at posttreatment...
February 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/27863698/striatal-h3k27-acetylation-linked-to-glutamatergic-gene-dysregulation-in-human-heroin-abusers-holds-promise-as-therapeutic-target
#10
Gabor Egervari, Joseph Landry, James Callens, John F Fullard, Panos Roussos, Eva Keller, Yasmin L Hurd
BACKGROUND: Opiate abuse and overdose reached epidemic levels in the United States. However, despite significant advances in animal and in vitro models, little knowledge has been directly accrued regarding the neurobiology of the opiate-addicted human brain. METHODS: We used postmortem human brain specimens from a homogeneous European Caucasian population of heroin users for transcriptional and epigenetic profiling, as well as direct assessment of chromatin accessibility in the striatum, a brain region central to reward and emotion...
September 28, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27799057/integrative-network-analysis-of-nineteen-brain-regions-identifies-molecular-signatures-and-networks-underlying-selective-regional-vulnerability-to-alzheimer-s-disease
#11
Minghui Wang, Panos Roussos, Andrew McKenzie, Xianxiao Zhou, Yuji Kajiwara, Kristen J Brennand, Gabriele C De Luca, John F Crary, Patrizia Casaccia, Joseph D Buxbaum, Michelle Ehrlich, Sam Gandy, Alison Goate, Pavel Katsel, Eric Schadt, Vahram Haroutunian, Bin Zhang
BACKGROUND: Alzheimer's disease (AD) is the most common form of dementia, characterized by progressive cognitive impairment and neurodegeneration. However, despite extensive clinical and genomic studies, the molecular basis of AD development and progression remains elusive. METHODS: To elucidate molecular systems associated with AD, we developed a large scale gene expression dataset from 1053 postmortem brain samples across 19 cortical regions of 125 individuals with a severity spectrum of dementia and neuropathology of AD...
November 1, 2016: Genome Medicine
https://www.readbyqxmd.com/read/27787548/creation-of-the-american-academy-of-facial-plastic-and-reconstructive-surgery-face-to-face-database
#12
Manoj T Abraham, Joseph J Rousso, Shirley Hu, Ryan F Brown, Augustine L Moscatello, J Charles Finn, Neha A Patel
No abstract text is available yet for this article.
October 27, 2016: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/27732689/activity-dependent-changes-in-gene-expression-in-schizophrenia-human-induced-pluripotent-stem-cell-neurons
#13
Panos Roussos, Boris Guennewig, Dominik C Kaczorowski, Guy Barry, Kristen J Brennand
Importance: Schizophrenia candidate genes participate in common molecular pathways that are regulated by activity-dependent changes in neurons. One important next step is to further our understanding on the role of activity-dependent changes of gene expression in the etiopathogenesis of schizophrenia. Objective: To examine whether neuronal activity-dependent changes of gene expression are dysregulated in schizophrenia. Design, Setting, and Participants: Neurons differentiated from human-induced pluripotent stem cells derived from 4 individuals with schizophrenia and 4 unaffected control individuals were depolarized using potassium chloride...
October 12, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27684045/long-term-analysis-of-lip-augmentation-with-superficial-musculoaponeurotic-system-smas-tissue-transfer-following-biplanar-extended-smas-rhytidectomy
#14
Matthew Allen Richardson, Daniel Elliott Rousso, William H Replogle
Importance: To our knowledge, long-term, objective results of lip augmentation using superficial musculoaponeurotic system (SMAS) tissue transfer beyond 1 year have not been previously described. Objective: To evaluate the efficacy, longevity, and safety of lip augmentation using SMAS tissue transfer. Design, Setting, and Participants: A retrospective single-blind cohort study was designed to evaluate all patients who underwent surgical lip augmentation using SMAS following rhytidectomy between January 1, 2000, and November, 16, 2015, at a private facial plastic surgery practice in Birmingham, Alabama...
January 1, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/27668389/gene-expression-elucidates-functional-impact-of-polygenic-risk-for-schizophrenia
#15
Menachem Fromer, Panos Roussos, Solveig K Sieberts, Jessica S Johnson, David H Kavanagh, Thanneer M Perumal, Douglas M Ruderfer, Edwin C Oh, Aaron Topol, Hardik R Shah, Lambertus L Klei, Robin Kramer, Dalila Pinto, Zeynep H Gümüş, A Ercument Cicek, Kristen K Dang, Andrew Browne, Cong Lu, Lu Xie, Ben Readhead, Eli A Stahl, Jianqiu Xiao, Mahsa Parvizi, Tymor Hamamsy, John F Fullard, Ying-Chih Wang, Milind C Mahajan, Jonathan M J Derry, Joel T Dudley, Scott E Hemby, Benjamin A Logsdon, Konrad Talbot, Towfique Raj, David A Bennett, Philip L De Jager, Jun Zhu, Bin Zhang, Patrick F Sullivan, Andrew Chess, Shaun M Purcell, Leslie A Shinobu, Lara M Mangravite, Hiroyoshi Toyoshiba, Raquel E Gur, Chang-Gyu Hahn, David A Lewis, Vahram Haroutunian, Mette A Peters, Barbara K Lipska, Joseph D Buxbaum, Eric E Schadt, Keisuke Hirai, Kathryn Roeder, Kristen J Brennand, Nicholas Katsanis, Enrico Domenici, Bernie Devlin, Pamela Sklar
Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants confer liability is uncertain. The CommonMind Consortium sequenced RNA from dorsolateral prefrontal cortex of people with schizophrenia (N = 258) and control subjects (N = 279), creating a resource of gene expression and its genetic regulation. Using this resource, ∼20% of schizophrenia loci have variants that could contribute to altered gene expression and liability. In five loci, only a single gene was involved: FURIN, TSNARE1, CNTN4, CLCN3 or SNAP91...
November 2016: Nature Neuroscience
https://www.readbyqxmd.com/read/27621208/associations-of-differential-schizotypal-dimensions-with-executive-working-memory-a-moderated-mediation-analysis
#16
Chrysoula Zouraraki, Ioannis Tsaousis, Penny Karamaouna, Leda Karagiannopoulou, Panos Roussos, Panos Bitsios, Stella G Giakoumaki
BACKGROUND: Increased schizotypal traits are observed in a percentage of the general population and in the schizophrenia-spectrum and have been associated with impairments in working memory. In this study we examined the effects of four schizotypal dimensions [Negative (NegS), Paranoid (ParS), Cognitive-Perceptual (CPS), Disorganized (DiS)] on executive working memory (EWM), as mediated by set-shifting, planning and control inhibition. We also examined whether these associations are moderated by family-history of psychosis...
August 21, 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27618466/cumulative-high-grade-squamous-intraepithelial-lesion-rate-and-need-for-surgical-intervention-of-atypical-squamous-cells-of-undetermined-significance-cytology-diagnosed-patients-a-prospective-study
#17
Stamatios Petousis, Ioannis Kalogiannidis, Chrysoula Margioula-Siarkou, Apostolos Mamopoulos, George Mavromatidis, Nikolaos Prapas, David Rousso
OBJECTIVE: Τhe study aimed to study the rate of atypical squamous cells of undetermined significance (ASCUS) that progressed to high-grade squamous intraepithelial lesions (HGSIL), as well as the number of patients who finally necessitated a surgical intervention during follow-up. METHODS: A prospective study was conducted on patients admitted for colposcopy during 2007-2012. We exclusively included those who presented with newly ASCUS diagnosis, while patients with a history of cervical intraepithelial neoplasia (CIN) were excluded...
September 13, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27590412/cardiac-contractility-modulation-in-heart-failure-patients-randomized-comparison-of-signal-delivery-through-one-vs-two-ventricular-leads
#18
Susanne Röger, Samir Said, Axel Kloppe, Thomas Lawo, Ulf Emig, Benny Rousso, David Gutterman, Martin Borggrefe, Jürgen Kuschyk
BACKGROUND: Cardiac contractility modulation (CCM) is an electrical stimulation treatment for symptomatic heart failure (HF) patients. The procedure involves implantation of two ventricular leads for delivery of CCM impulses. The purpose of this study is to compare the efficacy and safety of CCM when the signal is delivered through one vs. two ventricular leads. METHODS: This prospective blinded randomized trial enrolled 48 patients. Eligible subjects had symptoms despite optimal HF medications, left ventricular ejection fraction <40% and peakVO2≥9ml O2/kg/min...
January 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/27578465/prolonged-occupational-exposure-leads-to-allergic-airway-sensitization-and-chronic-airway-and-systemic-inflammation-in-professional-firefighters
#19
Niki Gianniou, Paraskevi Katsaounou, Efrossini Dima, Chariklia-Eleni Giannakopoulou, Matina Kardara, Vassiliki Saltagianni, Rodoula Trigidou, Aggeliki Kokkini, Petros Bakakos, Evangelos Markozannes, Eleni Litsiou, Alexandros Tsakatikas, Christos Papadopoulos, Charis Roussos, Nikolaos Koulouris, Nikoletta Rovina
BACKGROUND AND OBJECTIVES: Little data exist on short- and long-term effects of occupational exposure on airway and systemic inflammation in professional firefighters. We aimed to characterize airway and systemic inflammation in training firefighters with a maximum occupational exposure of 1 year compared to the long-term exposure of professional firefighters. METHODS: A questionnaire for symptoms and exposure, pulmonary function, atopy, bronchial hyper-responsiveness, and markers of inflammation in induced sputum, serum, bronchoalveolar lavage (BAL) fluid and bronchial biopsies were assessed in a total of 92 firefighters (63 full-time professionals and 29 trainees)...
September 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27552810/optimizing-computed-tomography-simulation-wait-times-in-a-busy-radiation-medicine-program
#20
Jerry Roussos, Payam Zahedi, Tara Spence, Lue-Ann Swanson, Fionna Li-Cheung, Fred Cops, Patrick Darcy, Veng Chhin, Elen Moyo, Padraig Warde, Sophie Foxcroft, Fei-Fei Liu
PURPOSE: An audit was conducted of patient schedules for computed tomography simulation (CT-Sim) scans within the Radiation Medicine Program at the Princess Margaret Cancer Centre to investigate opportunities for improved efficiencies, enhancing process, reducing rescanning rates, and decreasing wait times. METHODS AND MATERIALS: A 3-phased approach was undertaken to evaluate the current practice in the CT-Sim facility with a view toward implementing improvements...
January 2017: Practical Radiation Oncology
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