Sarah C Nuding, Lauren S Segers, Kimberly E Iceman, Russell O'Connor, Jay B Dean, Pierina A Valarezo, Dale Shuman, Irene C Solomon, Donald C Bolser, Kendall F Morris, Bruce G Lindsey
Hypoxia can trigger a sequence of breathing-related behaviors, from tachypnea to apneusis to apnea and gasping, an autoresuscitative behavior that, via large tidal volumes and altered intrathoracic pressure, can enhance coronary perfusion, carotid blood flow, and sympathetic activity, and thereby coordinate cardiac and respiratory functions. We tested the hypothesis that hypoxia-evoked gasps are amplified through a disinhibitory microcircuit within the inspiratory neuron chain and a distributed efference copy mechanism that generates coordinated gasp-like discharges concurrently in other circuits of the raphe-pontomedullary respiratory network...
November 10, 2023: bioRxiv