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https://www.readbyqxmd.com/read/29672731/amaze-a-randomized-controlled-trial-of-adjunct-surgery-for-atrial-fibrillation
#1
Samer A M Nashef, Simon Fynn, Yasir Abu-Omar, Tomasz J Spyt, Christine Mills, Colin C Everett, Julia Fox-Rushby, Jeshika Singh, Malcolm Dalrymple-Hay, Catherine Sudarshan, Massimiliano Codispoti, Peter Braidley, Francis C Wells, Linda D Sharples
OBJECTIVES: Atrial fibrillation (AF) reduces survival and quality of life (QoL). It can be treated at the time of major cardiac surgery using ablation procedures ranging from simple pulmonary vein isolation to a full maze procedure. The aim of this study is to evaluate the impact of adjunct AF surgery as currently performed on sinus rhythm (SR) restoration, survival, QoL and cost-effectiveness. METHODS: In a multicentre, Phase III, pragmatic, double-blinded, parallel-armed randomized controlled trial, 352 cardiac surgery patients with >3 months of documented AF were randomized to surgery with or without adjunct maze or similar AF ablation between 2009 and 2014...
April 17, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29667038/complex-drug-drug-gene-disease-interactions-involving-cytochromes-p450-systematic-review-of-published-case-reports-and-clinical-perspectives
#2
REVIEW
Flavia Storelli, Caroline Samer, Jean-Luc Reny, Jules Desmeules, Youssef Daali
Drug pharmacokinetics (PK) is influenced by multiple intrinsic and extrinsic factors, among which concomitant medications are responsible for drug-drug interactions (DDIs) that may have a clinical relevance, resulting in adverse drug reactions or reduced efficacy. The addition of intrinsic factors affecting cytochromes P450 (CYPs) activity and/or expression, such as genetic polymorphisms and diseases, may potentiate the impact and clinical relevance of DDIs. In addition, greater variability in drug levels and exposures has been observed when such intrinsic factors are present in addition to concomitant medications perpetrating DDIs...
April 17, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29667024/double-baltazar-procedure-for-repair-of-gastric-leakage-post-sleeve-gastrectomy-from-two-sites-case-report-of-new-surgical-technique
#3
Hussein Mcheimeche, Samer H Dbouk, Riad Saheli, Dany Lichaa, Louai S Chalaby
BACKGROUND: Staple line leak is one of the most challenging complications following laparoscopic sleeve gastrectomy, with a rate reaching near 1%. Its management often implicates a multidisciplinary approach and experienced bariatric and metabolic surgeons. The literature is abundant on various approaches to treat single staple line leak with variable results. But what to do in front of an intra-op incidental finding of double gastric fistulae? METHODS: In this article, we describe a new successful surgical treatment option of double Baltazar technique for a patient who was found to have two gastric fistulae post-sleeve gastrectomy...
April 18, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29663528/purely-off-clamp-robotic-partial-nephrectomy-preliminary-3-year-oncological-and-functional-outcomes
#4
Giuseppe Simone, Leonardo Misuraca, Gabriele Tuderti, Francesco Minisola, Mariaconsiglia Ferriero, Giuseppe Romeo, Manuela Costantini, Samer F Al-Rawashdah, Salvatore Guaglianone, Michele Gallucci
OBJECTIVES: To describe our surgical technique and to report perioperative, 3-year oncological and functional outcomes of a single-center series of purely off-clamp robotic partial nephrectomy. METHODS: A prospective renal cancer institutional database was queried, and data of consecutive patients treated with purely off-clamp robotic partial nephrectomy between 2010 and 2015 in a high-volume center were collected. Perioperative complications, and 3-year oncological and functional outcomes were assessed...
April 16, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29663328/gamma-aminobutyric-acid-agonists-for-antipsychotic-induced-tardive-dyskinesia
#5
REVIEW
Samer Alabed, Youssef Latifeh, Husam Aldeen Mohammad, Hanna Bergman
BACKGROUND: Chronic antipsychotic drug treatment may cause tardive dyskinesia (TD), a long-term movement disorder. Gamma-aminobutyric acid (GABA) agonist drugs, which have intense sedative properties and may exacerbate psychotic symptoms, have been used to treat TD. OBJECTIVES: 1. Primary objectiveThe primary objective was to determine whether using non-benzodiazepine GABA agonist drugs for at least six weeks was clinically effective for the treatment of antipsychotic-induced TD in people with schizophrenia, schizoaffective disorder or other chronic mental illnesses...
April 17, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29657474/analysis-of-a-generic-talar-prosthetic-with-a-biological-talus-a-cadaver-study
#6
Alexandra N Trovato, Troy D Bornes, Marwan El-Rich, Sukhvinder S Dhillon, Samer Adeeb, Nadr M Jomha
Treatment for talar avascular necrosis is challenging. This study evaluates the feasibility of a generic talar implant by cadaveric assessment. Ten cadaveric ankles were CT-scanned to determine talar implant size. The opposite ankles were CT-scanned with the biological talus and then with the implant. 3D ankle geometry was reconstructed and implant position was compared to the biological talus position. The averages among specimens' positive and negative average-deviations were 0.91 mm and 0.70 mm. Seventy percent of talar dome deviations between the biological talus and implant were within an acceptable range...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29655546/late-left-ventricular-rupture-as-a-complication-of-neochord-implantation-for-mitral-valve-repair
#7
Samer Kassem, Gabriella Ricciardi, Luca Salvi, Marina Alimento
No abstract text is available yet for this article.
March 10, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29651664/the-impact-of-chemotherapy-and-its-timing-on-survival-in-malignant-peritoneal-mesothelioma-treated-with-complete-debulking
#8
Samer A Naffouje, Kiara A Tulla, George I Salti
The current standard of treatment for malignant peritoneal mesothelioma (MPM) is cytoreductive surgery when the disease distribution is favorable. The role of chemotherapy, as an adjunct to surgery, remains unclear. The national database of mesothelioma was used to identify MPM patients who were treated with curative intent. Patients were divided into treatment groups: (1) chemotherapy only, (2) surgery only, (3) neoadjuvant chemotherapy + surgery, and (4) surgery + adjuvant chemotherapy. A negative control group of patients who did not receive any treatment was added (group 0)...
April 12, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29626543/exploring-rainfall-impacts-on-the-crash-risk-on-texas-roadways-a-crash-based-matched-pairs-analysis-approach
#9
Ehsan Omranian, Hatim Sharif, Samer Dessouky, Jose Weissmann
Interaction between adverse weather conditions and motor vehicle crashes is an important topic for traffic engineers and hydrometeorologists. With the recent availability of high resolution precipitation products (hourly, 4 × 4 km), it is possible to evaluate crash risk during rainfall events more accurately. Texas, the second largest state in the U.S., with a relatively high population density in its eastern part that receives significant rainfall from tropical events, experiences many hazardous traffic conditions every year...
April 4, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29625451/a-robust-optomotor-assay-for-assessing-the-efficacy-of-optogenetic-tools-for-vision-restoration
#10
Qi Lu, Tushar H Ganjawala, Samer Hattar, Gary W Abrams, Zhuo-Hua Pan
Purpose: To develop an animal behavioral assay for the quantitative assessment of the functional efficacy of optogenetic therapies. Methods: A triple-knockout (TKO) mouse line, Gnat1-/-Cnga3-/-Opn4-/-, and a double-knockout mouse line, Gnat1-/-Cnga3-/-, were employed. The expression of channelrhodopsin-2 (ChR2) and its three more light-sensitive mutants, ChR2-L132C, ChR2-L132C/T159C, and ChR2-132C/T159S, in inner retinal neurons was achieved using rAAV2 vectors via intravitreal delivery...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29625214/blast-exposure-disrupts-tonotopic-frequency-map-in-the-primary-auditory-cortex
#11
Samer Masri, Li S Zhang, Hao Luo, Edward Pace, Jinsheng Zhang, Shaowen Bao
Blast exposure can cause various auditory disorders including tinnitus, hyperacusis, and other central auditory processing disorders. While this is suggestive of patholologies in the central auditory system, the impact of blast exposure on central auditory processing remains poorly understood. Here we examined the effects of blast shockwaves on acoustic response properties and frequency mapping in auditory cortex. We found that multiunits recording from the auditory cortex exhibited higher acoustic thresholds and broader frequency tuning in blast-exposed animals...
April 3, 2018: Neuroscience
https://www.readbyqxmd.com/read/29623393/differences-in-laser-lead-extraction-of-infected-vs-non-infected-leads
#12
Simon Pecha, Liesa Castro, Julia Vogler, Matthias Linder, Nils Gosau, Stephan Willems, Hermann Reichenspurner, Samer Hakmi
We investigated the effect of systemic infection or lead endocarditis on the complexity and the success of laser lead extraction (LLE) procedures. Medical records of all patients undergoing LLE between January 2012 and March 2017 were screened with regard to information on systemic infection or lead endocarditis. We treated 184 patients using high-frequency 80 Hz laser sheaths in patients with lead implant duration of ≥ 12 months. Indications for lead extraction were systemic infection and lead endocarditis in 52 cases (28...
April 5, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29623251/central-serous-chorioretinopathy-with-angioid-streaks-a-rare-combination
#13
Ambreen Sarmad, Fadi Alfaqawi, Monali Chakrabarti, Samer Elsherbiny
Purpose: This rare case shows the presence of both angioid streaks (AS) and central serous chorioretinopathy (CSC) in the same eye. Methods: A 41-year-old Caucasian male who also has a positive family history of AS was diagnosed with angioid streaks. He was followed for few years, later developed CSC in his good eye. Results: Fundus fluorescein led to the diagnosis of CSC and indocyanine green angiography ruled out the possibility of idiopathic polypoidal choroidal vasculopathy (IPCV). The CSC followed a chronic course of non-resolution and finally half fluence photodynamic therapy was performed...
2018: GMS Ophthalmology Cases
https://www.readbyqxmd.com/read/29619259/primary-effusion-lymphoma-without-an-effusion-a-rare-case-of-solid-extracavitary-variant-of-primary-effusion-lymphoma-in-an-hiv-positive-patient
#14
Hamza Hashmi, Drew Murray, Samer Al-Quran, William Tse
Primary effusion lymphoma (PEL) is a unique form of non-Hodgkin lymphoma, usually seen in severely immunocompromised, HIV-positive patients. PEL is related to human herpesvirus-8 (HHV-8) infection, and it usually presents as a lymphomatous body cavity effusion in the absence of a solid tumor mass. There have been very few case reports of HIV-positive patients with HHV-8-positive solid tissue lymphomas not associated with an effusion (a solid variant of PEL). In the absence of effusion, establishing an accurate diagnosis can be challenging, and a careful review of morphology, immunophenotype, and presence of HHV-8 is necessary to differentiate from other subtypes of non-Hodgkin lymphoma...
2018: Case Reports in Hematology
https://www.readbyqxmd.com/read/29617993/navigation-of-lead-extraction-is-it-possible-impact-of-preprocedural-electrocardiogram-triggered-computed-tomography-on-navigation-of-lead-extraction
#15
Julia Vogler, Simon Pecha, Ryan Azarrafiy, Liesa Castro, Florian Deuschl, Clemens Spink, Matthias Linder, Ulrike von Hehn, Stephan Willems, Hermann Reichenspurner, Nils Gosau, Samer Hakmi
OBJECTIVES: As the number of transvenous lead extractions continues to increase, preprocedural protocols for this procedure must be assessed. The objective of this study was to determine whether an electrocardiogram (ECG)-triggered computed tomography (Et-CT) with three-dimensional (3D) reconstructions could aid lead extractors in choosing the optimal tools to improve procedural success and avoid complications. METHODS: In this study, 31 patients scheduled for transvenous lead extraction underwent a preprocedural Et-CT between January 2016 and May 2017...
March 30, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29617734/reply-to-walker-et-al
#16
Samer S El-Kamary, Mohamed Hashem, Ravi Jhaveri, Hesham El-Ghazaly
No abstract text is available yet for this article.
March 29, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29610387/exceptional-response-to-everolimus-in-a-novel-tuberous-sclerosis-complex-2-mutation-associated-metastatic-renal-cell-carcinoma
#17
Samer Alsidawi, Pashtoon Murtaza Kasi
Everolimus, an oral inhibitor of the mammalian target of rapamycin (mTOR) pathway, is currently approved for treatment of advanced renal-cell carcinoma (RCC) after failure of initial treatment with the tyrosine kinase inhibitors. Patients with tuberous sclerosis complex (TSC) syndrome can also develop RCC primarily mediated through mTOR signaling. However, the efficacy and duration of response of mTOR inhibition in patients with TSC-associated RCC is not well known. Herein, we describe a case of a patient with TSC2 -associated metastatic RCC with mutations H1620R and Y1650C who has had an exceptional response to everolimus in the frontline setting and continues to derive benefit from mTOR inhibition 2 yr into therapy...
April 2018: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/29609425/lower-urinary-tract-symptoms-in-elderly-population-with-multiple-sclerosis
#18
Camille Chesnel, Audrey Charlanes, Claire Hentzen, Nicolas Turmel, Frédérique Le Breton, Samer Sheikh Ismael, Gérard Amarenco
PURPOSE: The aim of this study is to compare the clinical and urodynamic characteristics of urinary disorders in multiple sclerosis (MS) patients in a geriatric population with a nongeriatric population. METHODS: This study was conducted retrospectively between 2010 and 2016. Each patient with MS aged 65 and older was matched with 2 patients with MS aged less than 65 in sex, form of MS, and Expended Disability Status Scale (EDSS). Demographic data, urinary symptoms, treatment, quality of life, repercussion of lower urinary tract symptoms on daily life activities and psychological state and urodynamic parameters were collected...
March 2018: International Neurourology Journal
https://www.readbyqxmd.com/read/29609423/intermittent-self-catheterization-in-older-adults-predictors-of-success-for-technique-learning
#19
Claire Hentzen, Rebecca Haddad, Samer Sheikh Ismael, Benoit Peyronnet, Xavier Gamé, Pierre Denys, Gilberte Robain, Gérard Amarenco
PURPOSE: The main goal of this retrospective study is to explore the predictors of success in learning clean intermittent self-catheterization (CISC) in patients over 65 years of age. The secondary goal is to assess whether in this population, the risk of failure to perform CISC is greater, compared with patients under 65 with similar pathologies. METHODS: All patients older than 65 consulting between January 2011 and January 2016 for learning CISC were included...
March 2018: International Neurourology Journal
https://www.readbyqxmd.com/read/29602524/individual-data-meta-analysis-for-the-study-of-survival-after-pulmonary-metastasectomy-in-colorectal-cancer-patients-a-history-of-resected-liver-metastases-worsens-the-prognosis
#20
Jon Zabaleta, Tomohiko Iida, Pierre E Falcoz, Samer Salah, José R Jarabo, Arlene M Correa, Maria G Zampino, Takashi Matsui, Sukki Cho, Francesco Ardissone, Kazuhiro Watanabe, Michel Gonzalez, Pascal Gervaz, Jose I Emparanza, Víctor Abraira
OBJECTIVES: To assess the impact of a history of liver metastases on survival in patients undergoing surgery for lung metastases from colorectal carcinoma. METHODS: We reviewed recent studies identified by searching MEDLINE and EMBASE using the Ovid interface, with the following search terms: lung metastasectomy, pulmonary metastasectomy, lung metastases and lung metastasis, supplemented by manual searching. Inclusion criteria were that the research concerned patients with lung metastases from colorectal cancer undergoing surgery with curative intent, and had been published between 2007 and 2014...
March 21, 2018: European Journal of Surgical Oncology
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