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Joseph L Bedont, Kayla E Rohr, Abhijith Bathini, Samer Hattar, Seth Blackshaw, Amita Sehgal, Jennifer A Evans
The suprachiasmatic nucleus (SCN) is the neural network that drives daily rhythms in behavior and physiology. The SCN encodes environmental changes through the phasing of cellular rhythms across its anteroposterior axis, but it remains unknown what signaling mechanisms regulate clock function along this axis. Here we demonstrate that arginine vasopressin (AVP) signaling organizes the SCN into distinct anteroposterior domains. Spatial mapping of SCN gene expression using in situ hybridization delineated anterior and posterior domains for AVP signaling components, including complementary patterns of V1a and V1b expression that suggest different roles for these two AVP receptors...
June 22, 2018: Journal of Comparative Neurology
Katarzyna Lubecka, Kirsty Flower, Megan Beetch, Jay Qiu, Lucinda Kurzava, Hannah Buvala, Adam Ruhayel, Samer Gawrieh, Suthat Liangpunsakul, Tracy Gonzalez, George McCabe, Naga Chalasani, James M Flanagan, Barbara Stefanska
Late onset of clinical symptoms in hepatocellular carcinoma (HCC) results in late diagnosis and poor disease outcome. Approximately 85% of individuals with HCC have underlying liver cirrhosis. However, not all cirrhotic patients develop cancer. Reliable tools that would distinguish cirrhotic patients who will develop cancer from those who will not are urgently needed. We used the Illumina HumanMethylation450 BeadChip microarray to test whether white blood cell DNA, an easily accessible source of DNA, exhibits site-specific changes in DNA methylation in blood of diagnosed HCC patients (post-diagnostic, 24 cases, 24 controls) and in prospectively collected blood specimens of HCC patients who were cancer-free at blood collection (pre-diagnostic, 21 cases, 21 controls)...
June 21, 2018: Epigenetics: Official Journal of the DNA Methylation Society
Mohamed Ali, Hatim Yagoub, Abdalla Ibrahim, Mohamed Ahmed, Munir Ibrahim, Jean Saunders, Alice Brennan, Donal Cahill, Terence Hennessy, Brian G Hynes, Samer Arnous, Thomas J Kiernan
AIM: The GuideLiner (GL) is a widely used catheter primarily in complex percutaneous coronary intervention (PCI). Deep seating of the GL and distal stent placement may be facilitated by the anchor balloon technique (ABT). METHODS: We aimed to prospectively analyze procedural details, technical success, complications and in-hospital outcome in patients who underwent PCI using the GL catheter and the ABT. RESULTS: A total of 118 patients underwent PCI with the aid of the GL and ABT...
June 21, 2018: Future Cardiology
Lily Chernyak-Hai, Samer Halabi
We examined whether potential help givers' future time perspective (FTP) accounts for the decision to give a person in need dependency-oriented help (i.e., providing the complete solution) or autonomy-oriented help (i.e., providing the means to solve a problem). In addition, building on past research on the effects of empathy in help giving decisions, the present research explored whether helpers' willingness to offer specific type of help is predicted by the interaction between FTP and interpersonal empathy...
June 21, 2018: British Journal of Social Psychology
Samer Amhaz-Escanlar, Alberto Jorge-Mora, Teresa Jorge-Mora, Manuel Febrero-Bande, Maximo-Alberto Diez-Ulloa
PURPOSE: Lateral mass screws combined with rods are the standard method for posterior cervical spine subaxial fixation. Several techniques have been described, among which the most used are Roy Camille, Magerl, Anderson and An. All of them are based on tridimensional angles. Reliability of freehand angle estimation remains poorly investigated. We propose a new technique based on on-site spatial references and compare it with previously described ones assessing screw length and neurovascular potential complications...
June 20, 2018: European Spine Journal
George I Salti, Samer A Naffouje
BACKGROUND: In light of the modern surgical trend towards minimally invasive surgery, we aim to assess the feasibility of hand-assisted laparoscopic (HAL) cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in peritoneal surface malignancy (PSM). METHODS: Patients with PSM secondary to colorectal cancer or pseudomyxoma peritonei with peritoneal cancer index (PCI) of ≤ 10 were considered for HAL CRS and HIPEC. One patient had PCI of 15 but based on the disease distribution laparoscopic-assisted CRS and HIPEC was thought to be feasible, thus was also included...
June 20, 2018: Surgical Endoscopy
Mohammed Shahait, Deborah Mukherji, Nadine Hamieh, Samer Nassif, Mark Jabbour, Raja Khauli, Muhammad Bulbul, Wassim Abou Kheir, Albert El Hajj
Background: Data from the Middle East regarding second primary malignancy (SPM) after radical prostatectomy are limited. Our objective was to estimate the overall risk of developing second primary malignancy (SPM) among Middle Eastern men with prostate cancer who underwent surgical extirpation of their prostate. Materials and methods: We conducted a retrospective study of 406 patients who underwent radical prostatectomy in a tertiary centre and who had no evidence of previous malignancy from 1998 to 2012...
June 2018: Prostate International
Robin J Dolleman, Samer Houri, Abhilash Chandrashekar, Farbod Alijani, Herre S J van der Zant, Peter G Steeneken
In the field of nanomechanics, parametric excitations are of interest since they can greatly enhance sensing capabilities and eliminate cross-talk. Above a certain threshold of the parametric pump, the mechanical resonator can be brought into parametric resonance. Here we demonstrate parametric resonance of suspended single-layer graphene membranes by an efficient opto-thermal drive that modulates the intrinsic spring constant. With a large amplitude of the optical drive, a record number of 14 mechanical modes can be brought into parametric resonance by modulating a single parameter: the pre-tension...
June 19, 2018: Scientific Reports
Ashish Kumar Singh, Saurav Das, Samer Singh, Varsha Rani Gajamer, Nilu Pradhan, Yangchen Doma Lepcha, Hare Krishna Tiwari
Commensal bacteria are the representative of the reservoir of antibiotic resistance genes present in a community. The usage of antibiotics along with the demographic factors is generally associated with an increase in antibiotics resistance in pathogens. Northeast (NE) India is untapped with regard to antibiotic resistance prevalence and spread. In the current study, the prevalence of antibiotic-resistant commensal Escherichia coli in pre-school and school-going children (n = 550, 1-14 years old) from the rural areas of the state of Sikkim-an NE Indian state, with respect to associated demographic factors was investigated...
2018: PloS One
Hanna K Sanoff, Richard M Goldberg, Anastasia Ivanova, Seamus O'Reilly, Samer S Kasbari, Richard D Kim, Ray McDermott, Dominic T Moore, William Zamboni, William Grogan, Allen Lee Cohn, Tanios S Bekaii-Saab, Gregory Leonard, Theresa Ryan, Olugbenga O Olowokure, Nishan H Fernando, John McCaffrey, Bassel F El-Rayes, Anne M Horgan, Gary Bradley Sherrill, George Hosni Yacoub, Bert H O'Neil
BACKGROUND: Regorafenib, a multikinase inhibitor that inhibits angiogenesis, growth, and proliferation, prolongs survival as monotherapy in patients with refractory colorectal cancer. This international, double-blind, placebo-controlled, multicenter trial assessed the efficacy of regorafenib with folinic acid, fluorouracil, and irinotecan (FOLFIRI) as a second-line treatment for metastatic colorectal cancer. METHODS: Patients with metastatic colorectal cancer who progressed on first-line oxaliplatin and fluoropyrimidine enrolled at 45 sites in the United States and Ireland...
June 15, 2018: Cancer
Ibrahim Aldoss, Tracey Stiller, Ni-Chun Tsai, Joo Y Song, Thai Cao, N Achini Bandara, Amadeep Salhotra, Samer Khaled, Ahmed Aribi, Monzr M Al Malki, Matthew Mei, Haris Ali, Ricardo Spielberger, Margaret O'Donnell, David Snyder, Thomas Slavin, Ryotaro Nakamura, Anthony S Stein, Stephen J Forman, Guido Marcucci, Vinod Pullarkat
Therapy-related acute lymphoblastic leukemia remains poorly defined due to a lack of large data sets recognizing the defining characteristics of this entity. We reviewed all consecutive cases of adult acute lymphoblastic leukemia treated at our institution between 2000 and 2017 and identified therapy-related cases-defined as acute lymphoblastic leukemia preceded by prior exposure to cytotoxic chemotherapy and/or radiation. Of 1022 patients with acute lymphoblastic leukemia, 93 (9.1%) were classified as therapy-related...
June 14, 2018: Haematologica
Erin S Coyne, Nathalie Bedard, Linda Wykes, Cynthia Stretch, Samer Jammoul, Sihan Li, Kezhuo Zhang, Robert S Sladek, Oliver F Bathe, Robert Thomas Jagoe, Barry I Posner, Simon S Wing
Muscle atrophy arises as a consequence of many chronic illnesses, as well as from prolonged glucocorticoid treatment and nutrient deprivation. We previously demonstrated that the USP19 deubiquitinating enzyme plays an important role in chronic glucocorticoid and denervation induced muscle wasting. However, the mechanisms by which USP19 exerts its effects remain unknown. To explore this further, we fasted mice for 48 hours to try to identify early differences in the response of WT and USP19 KO mice that could yield insights into the mechanisms of USP19 action...
June 12, 2018: Endocrinology
Pernille F Cromhout, Philip Moons, Lau C Thygesen, Samer Nashef, Sune Damgaard, Selina Kikkenborg Berg
Risk assessment in cardiac surgery traditionally consists of medical and physiological parameters. However, non-physiological factors have also been found to be predictive of poor outcomes following cardiac surgery. Therefore, the isolated focus on physiological parameters is questionable. This paper describes the emotional, behavioural, social and functional factors that have been established to play a role in outcomes following cardiac surgery. This forms a basis for future research, testing the value of these factors above and beyond the physiological parameters...
June 1, 2018: European Journal of Cardiovascular Nursing
Ahmed Aljuhayman, Ahmed Nazer, Abdulrahman Almuhrij, Samer Ali, Ahmed Alasker, Saeed Bin Hamri
No abstract text is available yet for this article.
July 2018: Urology Case Reports
Mehrdad Rakaee, Thomas K Kilvaer, Stig Manfred Dalen, Elin Richardsen, Erna-Elise Paulsen, Sigurd M Hald, Samer Al-Saad, Sigve Andersen, Tom Donnem, Roy M Bremnes, Lill-Tove Busund
The presence of tumor-infiltrating lymphocytes (TILs) positively impacts the outcome of non-small cell lung cancer (NSCLC) patients. Most previous studies have assessed TILs using different immunohistochemical assays. The purpose of this study was to develop and validate a histopathological scoring model for the assessment of TILs in whole tissue hematoxylin and eosin (H&E)-stained section slides of NSCLC patients and to evaluate the model in an immunoscore setting. Therefore, TIL was evaluated manually on H&E slides from 537 surgical specimens of primary resected stage I-III NSCLC patients...
June 6, 2018: Human Pathology
Mariola Smotrys, Tara Magge, Samer Alkhuja, Susheer Dilbagh Gandotra
This is a case of a 71-year-old homosexual man who presented with a 4-day history of fever, weakness and headaches, near syncope, nausea and poor oral intake. The patient denied recent travel or sick contacts but had significant tick bites in the last 4 weeks. A peripheral blood smear showed 0.5% parasitaemia with signet ring appearance organisms consistent with Babesia microti. Serology testing for HIV 1 and 2 by ELISA and western blot were positive. Treatment for Babesia was started and the patient improved...
June 8, 2018: BMJ Case Reports
Abdul-Latif Hamdan, Elie Khalifee, Hussein Jaffal, Anthony Ghanem, Samer Abou Rizk, Aya El Hage
OBJECTIVES: To examine the prevalence of dysphagia in patients presenting with dysphonia and diagnosed with non-neoplastic vocal fold pathology. METHODS: A total of 45 patients presenting with dysphonia and diagnosed with non-neoplastic vocal fold pathology and a control group matched according to age and gender were included. Patients with recent history of respiratory tract infection, laryngeal surgery or manipulation, neurologic disorders, head and neck tumors, or history of chemotherapy/radiotherapy were excluded...
June 5, 2018: Journal of Voice: Official Journal of the Voice Foundation
Samer Shamout, Sero Andonian, Hani Kabbara, Jacques Corcos, Lysanne Campeau
AIMS: Considering the growing role of urodynamic studies (UDS) in urology, we aimed to determine the most effective teaching method with objective evaluation for urodynamic skills, to improve training and patient care. METHODS: Urology residents (n = 20) post-graduate years 3-5 were randomized to receive either a UDS video training module or a standard UDS teaching document one week prior to an objective structured clinical examination (OSCE). The OSCE was a validated visual recognition exam with interpretation of 12 UDS tracing scenarios...
June 8, 2018: Neurourology and Urodynamics
Cyril J Awaida, Samer F Jabbour, Youssef A El Rayess, Joseph S El Khoury, Elio G Kechichian, Marwan W Nasr
BACKGROUND: Microbotox consists of the injection of microdroplets of botulinum toxin into the dermis to improve the different lower-face and neck aging components. No clinical trial has evaluated its effect on the different face and neck components and no study has compared it to the "Nefertiti Lift" procedure. METHODS: In this crossover study, patients previously treated with the "Nefertiti Lift" were injected using the Microbotox technique...
June 4, 2018: Plastic and Reconstructive Surgery
Samer Bou Jawde, Bradford J Smith, Adam Sonnenberg, Jason H T Bates, Bela Suki
OBJECTIVE: While many studies rely on flow and pressure measurements in small animal models of respiratory disease, such measurements can however be inaccurate and difficult to obtain. Thus, the goal of this study was to design and implement an easy to manufacture and accurate sensor capable of monitoring flow. APPROACH: We designed and 3-D printed a flowmeter and utilized parametric (resistance and inertance) and nonparametric (polynomial and Volterra series) system identification to characterize the device...
June 7, 2018: Physiological Measurement
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