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Syed Jehangir Shah, Muhammad Shahzad Anjam, Badou Mendy, Muhammad Arslan Anwer, Samer S Habash, Jose L Lozano-Torres, Florian M W Grundler, Shahid Siddique, Robert Hancock
When nematodes invade and subsequently migrate within plant roots, they generate cell wall fragments (in the form of oligogalacturonides; OGs) that can act as damage-associated molecular patterns and activate host defence responses. However, the molecular mechanisms mediating damage responses in plant-nematode interactions remain unexplored. Here, we characterized the role of a group of cell wall receptor proteins in Arabidopsis, designated as polygalacturonase-inhibiting proteins (PGIPs), during infection with the cyst nematode Heterodera schachtii and the root-knot nematode Meloidogyne incognita...
October 19, 2017: Journal of Experimental Botany
Warren Noel, Romain Bosc, Samer Jabbour, Elio Kechichian, Barbara Hersant, Jean-Paul Meningaud
BACKGROUND: Internet use for health information has dramatically increased in the past decade. Mobile medical applications (MMAs) could be a useful tool to improve postoperative patient education and care. The objective of this study is to evaluate the impact of an MMA on patient care in plastic surgery. METHODS: An MMA was developed to improve postoperative plastic surgery patients care. All patients who underwent surgery at our plastic surgery department between August and November 2014 and were willing to download the MMA were included...
October 19, 2017: Annals of Plastic Surgery
Samer S Habash, Miroslaw Sobczak, Shahid Siddique, Boris Voigt, Abdelnaser Elashry, Florian M W Grundler
The plant-parasitic nematode Heterodera schachtii is an obligate biotroph that induces syncytial feeding sites in roots of its hosts. Nematodes produce effectors that are secreted into the host and facilitate infection process. Here we identified H. schachtii protein disulphide isomerase (HsPDI) as a putative effector that interferes with the host's redox status. In situ hybridization showed that HsPdi is specifically localized within esophageal glands of pre-parasitic second stage juveniles (J2). HsPdi is up-regulated in the early parasitic J2s...
October 19, 2017: Scientific Reports
Alexander M Bernhardt, Mathias Hillebrand, Yalin Yildirim, Samer Hakmi, Florian M Wagner, Stefan Blankenberg, Hermann Reichenspurner, Edith Lubos
OBJECTIVES: Left-sided unloading during extracorporeal membrane oxygenation (ECMO) therapy is crucial to prevent pulmonary oedema and facilitate ventricular recovery. We present the case of a 55-year-old man under ECMO therapy with pre-existing left ventricular (LV) thrombus formation and in need of ventricular unloading. METHODS: We implanted a 21-Fr TandemHeart Protek Solo trans-septal cannula into the left atrium using a trans-septal approach via the femoral vein...
September 1, 2017: Interactive Cardiovascular and Thoracic Surgery
Simon Pecha, Julia Vogler, Hermann Reichenspurner, Samer Hakmi
Injuries to the superior vena cava (SVC) during transvenous lead extraction (TLE) procedures are a rare but life-threatening complication. The Bridge Occlusion Balloon (BOB) is specifically designed for temporary SVC occlusion in TLE procedures. We report the first case of a 27-year-old man using the BOB as a safety net in a high-risk TLE procedure. This patient, with a congenitally corrected transposition of the great arteries and a third-degree atrioventricular block, presented with 4 dysfunctional pacemaker leads, venous stenosis and the necessity for a new pacemaker system...
September 8, 2017: Interactive Cardiovascular and Thoracic Surgery
Samer Bazzi, Emale El-Darzi, Tina McDowell, Helmout Modjtahedi, Satvinder Mudan, Marcel Achkar, Charles Akle, Humam Kadara, Georges M Bahr
Heat-killed (HK) Mycobacterium obuense (NCTC13365) is currently being evaluated in the clinic as an immunotherapeutic agent for cancer treatment. Yet, the molecular underpinnings underlying immunomodulatory properties of HK M. obuense are still largely undefined. To fill this void, we sought to perform immunophenotyping, chemokine/cytokine release analysis and genome-wide characterization of monocyte-derived macrophages (MDM) in which monocytes were originally isolated from healthy donors and differentiated by HK M...
2017: Frontiers in Immunology
Kyoung-Han Kim, Yun Hye Kim, Joe Eun Son, Ju Hee Lee, Sarah Kim, Min Seon Choe, Joon Ho Moon, Jian Zhong, Kiya Fu, Florine Lenglin, Jeong-Ah Yoo, Philip J Bilan, Amira Klip, Andras Nagy, Jae-Ryong Kim, Jin Gyoon Park, Samer Mi Hussein, Kyung-Oh Doh, Chi-Chung Hui, Hoon-Ki Sung
Intermittent fasting (IF), a periodic energy restriction, has been shown to provide health benefits equivalent to prolonged fasting or caloric restriction. However, our understanding of the underlying mechanisms of IF-mediated metabolic benefits is limited. Here we show that isocaloric IF improves metabolic homeostasis against diet-induced obesity and metabolic dysfunction primarily through adipose thermogenesis in mice. IF-induced metabolic benefits require fasting-mediated increases of vascular endothelial growth factor (VEGF) expression in white adipose tissue (WAT)...
October 17, 2017: Cell Research
Elisabeth Höhn, Antje Aschendorff, Susan Arndt, Samer Elsheikh, Till F Jakob
No abstract text is available yet for this article.
October 16, 2017: Laryngo- Rhino- Otologie
Hani El-Mowafi, Mazen Abulsaad, Yasser Kandil, Ahmed El-Hawary, Samer Ali
BACKGROUND: Ankle fusion is difficult to achieve in the diabetic Charcot ankle Brodsky type 3a because of the poor quality of the bone and the inability to achieve a stable biomechanical construct. The aim of this study was to report the outcome of ankle fusion using a combination of an intramedullary nail and a circular external fixator in patients with diabetic Charcot arthropathy. METHODS: We prospectively studied 24 patients with diabetic Charcot arthropathy of the ankle who were treated by fusion of the tibiotalar joint using a combined retrograde intramedullary nail and Ilizarov external fixator...
October 1, 2017: Foot & Ankle International
Marvin Ryou, Kenneth R McQuaid, Christopher C Thompson, Steven Edmundowicz, Klaus Mergener, Barham Abu Dayyeh, Caroline Apovian, Carol Burke, Bipan Chand, Anil Chandraker, Thomas Deas, William Dietz, Brian Dunkin, Opella Ernest, Douglas Faigel, Shawn Garber, Osama Hamdy, Lee Kaplan, Nitin Kumar, Robert Kushner, Michael C Larsen, Herbert Lerner, Glenn Littenberg, Christos Mantzoros, Samer Mattar, Rachel Moore, Mary Rinella, Richard Rothstein, Dean Schillinger, Bonnie Spring, Shelby Sullivan, Jeffrey Tice, John Vargo, Erik Wilson, Karen Woods, Natan Zundel
No abstract text is available yet for this article.
October 11, 2017: Gastrointestinal Endoscopy
Simon Pecha, Ayhan Ayikli, Iris Wilke, Samer Hakmi, Yalin Yildirim, Nils Gosau, Hermann Reichenspurner, Stephan Willems, Muhammet Ali Aydin
Recent studies have shown that subcutaneous or subfascial pacemaker- and ICD implantation with continued oral anticoagulation therapy is associated with lower risk for bleeding complications, when compared to heparin bridging strategies. However, ICD generators are often implanted submuscularly. We therefore compared the bleeding risk with continued phenprocoumon therapy vs. heparin bridging in patients receiving submuscular ICD implantation. Between 01/2013 and 12/2013, 104 patients with need for oral anticoagulation received submuscular ICD or CRT-D implantation in our institution...
October 13, 2017: Heart and Vessels
Marvin Ryou, Kenneth R McQuaid, Christopher C Thompson, Steven Edmundowicz, Klaus Mergener, Barham Abu Dayyeh, Caroline Apovian, Carol Burke, Bipan Chand, Anil Chandraker, Thomas Deas, William Dietz, Brian Dunkin, Opella Ernest, Douglas Faigel, Shawn Garber, Osama Hamdy, Lee Kaplan, Nitin Kumar, Robert Kushner, Michael C Larsen, Herbert Lerner, Glenn Littenberg, Christos Mantzoros, Samer Mattar, Rachel Moore, Mary Rinella, Richard Rothstein, Dean Schillinger, Bonnie Spring, Shelby Sullivan, Jeffrey Tice, John Vargo, Erik Wilson, Karen Woods, Natan Zundel
No abstract text is available yet for this article.
September 8, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
Kristen A Stafford, Laurence S Magder, Laura L Hungerford, Jack M Guralnik, Samer S El-Kamary, Mona Baumgarten, Robert R Redfield
OBJECTIVE: To estimate the association between age at antiretroviral therapy (ART) initiation and immunologic response over time by stratum of baseline CD4 cell counts. DESIGN: Retrospective cohort analysis of data pooled from four PEPFAR funded countries in sub-Saharan Africa METHODS:: General linear models were used to estimate the mean CD4 cell count by age group within groups defined by baseline CD4 cell count. Kaplan-Meier methods were used to estimate time to achieving a CD4 cell count of at least 500 cells/mm3 by age group and stratified by baseline CD4 cell count...
October 12, 2017: AIDS
Samer Alabed, Ammar Sabouni, Rui Providencia, Edmond Atallah, Mohammed Qintar, Timothy Ja Chico
BACKGROUND: People with supraventricular tachycardia (SVT) frequently are symptomatic and present to the emergency department for treatment. Although vagal manoeuvres may terminate SVT, they often fail, and subsequently adenosine or calcium channel antagonists (CCAs) are administered. Both are known to be effective, but both have a significant side effect profile. This is an update of a Cochrane review previously published in 2006. OBJECTIVES: To review all randomised controlled trials (RCTs) that compare effects of adenosine versus CCAs in terminating SVT...
October 12, 2017: Cochrane Database of Systematic Reviews
Samer Aphrham, Qing Pan, Sarah F Zaccarine, Kevin M Felter, Jos Thieme, Karin J H van den Nieuwenhuijzen, Johan E Ten Elshof, Annemarie Huijser
The effect of water addition during preparation of a CH3NH3PbI3 layer on the photodynamics is studied by femtosecond transient absorption. Both the regular perovskite and the aqueous analogue show charge thermalisation on a ca. 500 fs time scale. This process is however less pronounced in the latter layer. The spectral feature associated with hot charges does not fully decay on this time scale, but also shows a long-lived (sub-ns) component. As water molecules may interfere with the hydrogen bonding between the CH3NH3+ cations and the inorganic cage, this effect is possibly caused by immobilisation of cation motion, suggesting a key role of CH3NH3+ dipole reorientation in charge thermalisation...
October 12, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
Samer Jallad, Anupa Shah, Jeetesh Bhardwa
Knotting of feeding tubes or urinary catheters has been reported as a rare complication in paediatrics when draining the bladder. This is caused by inserting thin flexible tubes too far in, allowing it to coil. We present a case of a 70-year-old woman who was catheterised during a routine spinal surgery, and the catheter coiled and balloon failed to deflate requiring a cystostopic approach to puncture the balloon and remove it. Awareness of this complication in female catheterisation and education on length of catheter insertion is important to avoid this...
October 10, 2017: BMJ Case Reports
Samer Nikolaos Al-Αchmar, Sofoklis Stavrou, Athanasios Protopapas, Peter Drakakis, Panagiota Siemou, Ioannis Chatzipapas
INTRODUCTION: Ovarian vein thrombosis is a rare but potentially serious complication after surgical and gynecologic procedures such as oophorectomy and hysterectomy. The association of this event with laparoscopic hysterectomy in particular, is very rare. Only two cases have been described so far. PRESENTATION OF CASE: We present a case of ovarian vein thrombosis after laparoscopic hysterectomy in a 40-year-old with deep endometriosis and multiple intramural uterine myomas...
October 4, 2017: International Journal of Surgery Case Reports
Samer Tannus, Safak Hatirnaz, Justin Tan, Baris Ata, Seang-Lin Tan, Ebru Hatirnaz, Mine Kenat-Pektas, Michael-Haim Dahan
OBJECTIVE: In vitro maturation (IVM) of human oocytes can be an alternative treatment option to conventional in vitro fertilization. Women with polycystic ovary syndrome (PCOS) are considered the classical candidates for IVM because of the associated ovarian morphology and because IVM diminishes the risk of developing ovarian hyperstimulation syndrome. The objective of this study was to identify predictive factors for live birth in a cohort of women with PCOS who underwent IVM. METHODS: This retrospective study included 159 patients with PCOS who had IVM cycles in which single or double embryo transfer was performed...
October 9, 2017: Archives of Gynecology and Obstetrics
Samer A Kharroubi
BACKGROUND: Valuations of health state descriptors such as EQ-5D or SF6D have been conducted in different countries. There is a scope to make use of the results in one country as informative priors to help with the analysis of a study in another, for this to enable better estimation to be obtained in the new country than analyzing its data separately. METHODS: Data from 2 EQ-5D valuation studies were analyzed using the time trade-off technique, where values for 42 health states were devised from representative samples of the UK and US populations...
October 6, 2017: Health and Quality of Life Outcomes
Mundackal S Divya, Vazhanthodi A Rasheed, Tiffany Schmidt, Soundararajan Lalitha, Samer Hattar, Jackson James
Retinal ganglion cell (RGC) transplantation is a promising strategy to restore visual function resulting from irreversible RGC degeneration occurring in glaucoma or inherited optic neuropathies. We previously demonstrated FGF2 induced differentiation of mouse embryonic stem cells (ESC) to RGC lineage, capable of retinal ganglion cell layer (GCL) integration upon transplantation. Here, we evaluated possible improvement of visual function by transplantation of ES cell derived neural progenitors in RGC depleted glaucoma mice models...
2017: Frontiers in Cellular Neuroscience
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