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https://www.readbyqxmd.com/read/28634329/long-days-enhance-recognition-memory-and-increase-insulin-like-growth-factor-2-in-the-hippocampus
#1
Adriano Dellapolla, Ian Kloehn, Harshida Pancholi, Ben Callif, David Wertz, Kayla E Rohr, Matthew M Hurley, Kimberly M Baker, Samer Hattar, Marieke R Gilmartin, Jennifer A Evans
Light improves cognitive function in humans; however, the neurobiological mechanisms underlying positive effects of light remain unclear. One obstacle is that most rodent models have employed lighting conditions that cause cognitive deficits rather than improvements. Here we have developed a mouse model where light improves cognitive function, which provides insight into mechanisms underlying positive effects of light. To increase light exposure without eliminating daily rhythms, we exposed mice to either a standard photoperiod or a long day photoperiod...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28632400/evidence-of-noncompetent-hiv-after-ex-vivo-purging-among-art-suppressed-individuals
#2
Sadia Samer, Gislene Namiyama, Telma Oshiro, Muhammad Shoaib Arif, Wanessa Cardoso da Silva, Maria Cecilia Araripe Sucupira, Luiz Mario Janini, Ricardo Sobhie Diaz
No abstract text is available yet for this article.
June 20, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28627051/investigating-the-job-satisfaction-of-healthcare-providers-at%C3%A2-primary-healthcare-centres-in-lebanon-a-national-cross-sectional-study
#3
Mohamad Alameddine, Maysa Baroud, Samer Kharroubi, Randa Hamadeh, Walid Ammar, Hikma Shoaib, Hiba Khodr
Low job satisfaction is linked to higher staff turnover and intensified shortages in healthcare providers (HCP). This study investigates the level of, and factors associated with, HCP job satisfaction in the national primary healthcare (PHC) network in Lebanon. The study adopts a cross-sectional design to survey HCP at 99 PHC centres distributed across the country between October 2013 and May 2014. The study questionnaire consisted of four sections: socio-demographics/professional background, employment characteristics, level of job satisfaction (Measure of Job Satisfaction scale) and level of professional burnout (Maslach Burnout Inventory-HSS scale)...
June 18, 2017: Health & Social Care in the Community
https://www.readbyqxmd.com/read/28624543/impact-of-health-care-insurance-status-on-treatment-outcomes-of-acute-myeloid-leukemia
#4
Samer A Srour, Michael Machiorlatti, Namali T Pierson, Usman Z Bhutta, Mohamad Cherry, George B Selby, David M Thompson, Sara K Vesely, Carla D Kurkjian
INTRODUCTION: Insurance status has been found to influence treatment outcomes in various solid tumors. Limited data with conflicting results are available in patients with acute myeloid leukemia (AML). We examined the impact of health insurance at diagnosis on AML treatment outcomes. PATIENTS AND METHODS: All consecutive adult patients (≥ 18 years of age) diagnosed with AML between 2002 and 2011 and followed through August 2013 were included. Survival estimates were calculated by Kaplan-Meier survival curves...
May 10, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28623522/h3-k27m-mutations-are-extremely-rare-in-posterior-fossa-group-a-ependymoma
#5
Scott Ryall, Miguel Guzman, Samer K Elbabaa, Betty Luu, Stephen C Mack, Michal Zapotocky, Michael D Taylor, Cynthia Hawkins, Vijay Ramaswamy
BACKGROUND: Mutations in the tail of histone H3 (K27M) are frequently found in pediatric midline high-grade glioma's but have rarely been reported in other malignancies. Recently, recurrent somatic nucleotide variants in histone H3 (H3 K27M) have been reported in group A posterior fossa ependymoma (EPN_PFA), an entity previously described to have no recurrent mutations. However, the true incidence of H3 K27M mutations in EPN_PFA is unknown. METHODS: In order to discern the frequency of K27M mutations in histone H3 in EPN_PFA, we analyzed 151 EPN_PFA previously profiled with genome-wide methylation arrays using a validated droplet digital PCR assay...
June 16, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28620855/physicochemical-characteristics-mutagenicity-and-genotoxicity-of-airborne-particles-under-industrial-and-rural-influences-in-northern-lebanon
#6
Pamela N Melki, Frédéric Ledoux, Samer Aouad, Sylvain Billet, Bilal El Khoury, Yann Landkocz, Roula M Abdel-Massih, Dominique Courcot
In this work, the main objectives were to assess the mutagenic and genotoxic effects of fine particulate matter collected in an industrial influenced site in comparison with a non-industrial influenced one (rural site) and to relate the particulate matter (PM) composition to the observed genotoxic effects. At the industrial influenced site, higher concentrations of phosphates, trace metals, and polycyclic aromatic hydrocarbons (PAHs) in particles could be related to the contributions of quarries, fertilizer producer, cement plants, and tires burning...
June 15, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28617242/a-subset-of-iprgcs-regulates-both-maturation-of-the-circadian-clock-and-segregation-of-retinogeniculate-projections-in-mice
#7
Kylie S Chew, Jordan M Renna, David S McNeill, Diego Carlos Fernandez, William Thomas Keenan, Michael B Thomsen, Jennifer L Ecker, Gideon S Loevinsohn, Cassandra VanDunk, Daniel C Vicarel, Adele Tufford, Shijun Weng, Paul A Gray, Michel Cayouette, Erik D Herzog, Haiqing Zhao, David M Berson, Samer Hattar
The visual system consists of two major subsystems, image-forming circuits that drive conscious vision and non-image-forming circuits for behaviors such as circadian photoentrainment. While historically considered non-overlapping, recent evidence has uncovered crosstalk between these subsystems. Here we investigated shared developmental mechanisms. We revealed an unprecedented role for light in the maturation of the circadian clock and discovered that intrinsically photosensitive retinal ganglion cells (ipRGCs) are critical for this refinement process...
June 15, 2017: ELife
https://www.readbyqxmd.com/read/28616334/surgeons-high-risk-interventions-and-the-birth-of-the-star-chamber
#8
Samer A M Nashef
No abstract text is available yet for this article.
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28616118/stress-urinary-incontinence-in-women-current-and-emerging-therapeutic-options
#9
REVIEW
Samer Shamout, Lysanne Campeau
Surgical management of stress urinary incontinence (SUI) is most commonly achieved by midurethral synthetic sling (MUS) insertion as a first-line surgical option. A great deal of research continues to evolve new management strategies to reach an optimal balance of high efficacy and minimal adverse events. This expert opinion review provides a brief and comprehensive discussion of recent advances and ongoing research in the management of SUI, with an emphasis on single-incision mini-slings, vaginal laser treatment, and cell-based therapy...
June 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28614785/drag-reducing-polymers-decrease-hepatic-injury-and-metastases-after-liver-ischemia-reperfusion
#10
Samer Tohme, Marina V Kameneva, Hamza O Yazdani, Vikas Sud, Julie Goswami, Patricia Loughran, Hai Huang, Richard L Simmons, Allan Tsung
INTRODUCTION: Surgery, a crucial therapeutic modality in the treatment of solid tumors, can induce sterile inflammatory processes which can result in metastatic progression. Liver ischemia and reperfusion (I/R) injury, an inevitable consequence of hepatic resection of metastases, has been shown to foster hepatic capture of circulating cancer cells and accelerate metastatic growth. Efforts to reduce these negative consequences have not been thoroughly investigated. Drag reducing polymers (DRPs) are blood-soluble macromolecules that can, in nanomolar concentrations, increase tissue perfusion, decrease vascular resistance and decrease near-wall microvascular concentration of neutrophils and platelets thereby possibly reducing the inflammatory microenvironment...
May 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28609654/intertumoral-heterogeneity-within-medulloblastoma-subgroups
#11
Florence M G Cavalli, Marc Remke, Ladislav Rampasek, John Peacock, David J H Shih, Betty Luu, Livia Garzia, Jonathon Torchia, Carolina Nor, A Sorana Morrissy, Sameer Agnihotri, Yuan Yao Thompson, Claudia M Kuzan-Fischer, Hamza Farooq, Keren Isaev, Craig Daniels, Byung-Kyu Cho, Seung-Ki Kim, Kyu-Chang Wang, Ji Yeoun Lee, Wieslawa A Grajkowska, Marta Perek-Polnik, Alexandre Vasiljevic, Cecile Faure-Conter, Anne Jouvet, Caterina Giannini, Amulya A Nageswara Rao, Kay Ka Wai Li, Ho-Keung Ng, Charles G Eberhart, Ian F Pollack, Ronald L Hamilton, G Yancey Gillespie, James M Olson, Sarah Leary, William A Weiss, Boleslaw Lach, Lola B Chambless, Reid C Thompson, Michael K Cooper, Rajeev Vibhakar, Peter Hauser, Marie-Lise C van Veelen, Johan M Kros, Pim J French, Young Shin Ra, Toshihiro Kumabe, Enrique López-Aguilar, Karel Zitterbart, Jaroslav Sterba, Gaetano Finocchiaro, Maura Massimino, Erwin G Van Meir, Satoru Osuka, Tomoko Shofuda, Almos Klekner, Massimo Zollo, Jeffrey R Leonard, Joshua B Rubin, Nada Jabado, Steffen Albrecht, Jaume Mora, Timothy E Van Meter, Shin Jung, Andrew S Moore, Andrew R Hallahan, Jennifer A Chan, Daniela P C Tirapelli, Carlos G Carlotti, Maryam Fouladi, José Pimentel, Claudia C Faria, Ali G Saad, Luca Massimi, Linda M Liau, Helen Wheeler, Hideo Nakamura, Samer K Elbabaa, Mario Perezpeña-Diazconti, Fernando Chico Ponce de León, Shenandoah Robinson, Michal Zapotocky, Alvaro Lassaletta, Annie Huang, Cynthia E Hawkins, Uri Tabori, Eric Bouffet, Ute Bartels, Peter B Dirks, James T Rutka, Gary D Bader, Jüri Reimand, Anna Goldenberg, Vijay Ramaswamy, Michael D Taylor
While molecular subgrouping has revolutionized medulloblastoma classification, the extent of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes. After integration of somatic copy-number alterations, and clinical features specific to each cluster, we identify 12 different subtypes of medulloblastoma...
June 12, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28600657/validation-of-demographics-etiology-and-risk-factors-for-chronic-pancreatitis-in-the-usa-a-report-of-the-north-american-pancreas-study-naps-group
#12
Darwin L Conwell, Peter A Banks, Bimaljit S Sandhu, Stuart Sherman, Samer Al-Kaade, Timothy B Gardner, Michelle A Anderson, C Mel Wilcox, Michele D Lewis, Thiruvengadam Muniraj, Christopher E Forsmark, Gregory A Cote, Nalini M Guda, Ye Tian, Joseph Romagnuolo, Stephen R Wisniewski, Randall Brand, Andres Gelrud, Adam Slivka, David C Whitcomb, Dhiraj Yadav
BACKGROUND/OBJECTIVES: Our aim was to validate recent epidemiologic trends and describe the distribution of TIGAR-O risk factors in chronic pancreatitis (CP) patients. METHODS: The NAPS-2 Continuation and Validation (NAPS2-CV) study prospectively enrolled 521 CP patients from 13 US centers from 2008 to 2012. CP was defined by definitive changes in imaging, endoscopy, or histology. Data were analyzed after stratification by demographic factors, physician-defined etiology, participating center, and TIGAR-O risk factors...
June 9, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28595337/response-to-the-association-of-progressive-tension-sutures-and-drains-seems-to-decrease-the-drainage-output-and-seroma-formation-in-abdominoplasty
#13
Samer Jabbour, Rani Makhoul, Cyril Awaida, Philippe Levan, Taliah Schmitt, Marwan Nasr
No abstract text is available yet for this article.
June 8, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28593481/molecular-survey-of-coxiella-burnetii-in-wildlife-and-ticks-at-wildlife-livestock-interfaces-in-kenya
#14
David Ndeereh, Gerald Muchemi, Andrew Thaiyah, Moses Otiende, Samer Angelone-Alasaad, Michael J Jowers
Coxiella burnetii is the causative agent of Q fever, a zoonotic disease of public health importance. The role of wildlife and their ticks in the epidemiology of C. burnetii in Kenya is unknown. This study analysed the occurrence and prevalence of the pathogen in wildlife and their ticks at two unique wildlife-livestock interfaces of Laikipia and Maasai Mara National Reserve (MMNR) with the aim to determine the potential risk of transmission to livestock and humans. Blood from 79 and 73 animals in Laikipia and MMNR, respectively, and 756 and 95 ixodid ticks in each of the areas, respectively, was analysed...
June 7, 2017: Experimental & Applied Acarology
https://www.readbyqxmd.com/read/28590322/off-pump-versus-on-pump-coronary-artery-bypass-surgery-graft-patency-assessment-with-coronary-computed-tomographic-angiography-a-prospective-multicenter-randomized-controlled-pilot-study
#15
Nicolas Noiseux, Louis-Mathieu Stevens, Carl Chartrand-Lefebvre, Gilles Soulez, Ignacio Prieto, Fadi Basile, Samer Mansour, Adel M Dyub, Teresa M Kieser, André Lamy
PURPOSE: A large multicenter randomized trial (RCT) is needed to assess off-pump coronary artery bypass graft (CABG) patency when performed by skilled surgeons. This prospective multicenter randomized pilot study compares graft patency after on-pump and off-pump techniques and addresses the feasibility of such an RCT. MATERIALS AND METHODS: Consecutive patients were prospectively recruited for ≥64-slice computed tomography angiography graft patency assessment 1 year after randomization to off-pump or on-pump CABG...
June 5, 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28586198/electronic-spectra-of-tris-2-2-bipyridine-m-ii-complex-ions-in-vacuo-m-fe-and-os
#16
Shuang Xu, James E T Smith, Samer Gozem, Anna I Krylov, J Mathias Weber
We measured the electronic spectra of mass-selected [M(bpy)3](2+) (M = Fe and Os, bpy = 2,2'-bipyridine) ions in vacuo by photodissociation spectroscopy of their N2 adducts, [M(bpy)3](2+)·N2. Extensive band systems in the visible (predominantly charge transfer) and near-ultraviolet (ππ*) spectral regions are reported. The [M(bpy)3](2+)·N2 target ions were prepared by condensing N2 onto electrosprayed ions in a cryogenic ion trap at ca. 25 K and then mass-selected by time-of-flight mass spectrometry. The electronic photodissociation spectra of the cold, gas-phase ions closely reflect their intrinsic properties, i...
June 6, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28578800/geometric-analysis-of-the-talus-and-development-of-a-generic-talar-prosthetic
#17
Alexandra Trovato, Marwan El-Rich, Samer Adeeb, Suki Dhillon, Nadr Jomha
BACKGROUND: Trauma to the talus can result in fracture, avascular necrosis and structural collapse. Treatment has been limited to surgical fusion and total ankle arthroplasty. Total ankle arthroplasty may not be an appropriate treatment for avascular necrosis while surgical fusion of the joint limits mobility. Custom-made implants have recently been used to address these limitations but have lengthy delays between injury and surgery and higher associated costs. A generic talar prosthesis available in various sizes may serve as a suitable alternative...
June 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28575065/does-published-research-on-non-communicable-disease-ncd-in-arab-countries-reflect-ncd-disease-burden
#18
Abla M Sibai, Neil V Singh, Samer Jabbour, Shadi Saleh, Sawsan Abdulrahim, Farah Naja, Soha Yazbek
OBJECTIVES: To review trends in non-communicable (NCD) research output in the Arab region, in terms of quantity and quality, study design, setting and focus. We also examined differences by time and place, and assessed gaps between research output and NCD burden. METHODS: A scoping review of a total of 3,776 NCD-related reports published between 2000 and 2013 was conducted for seven Arab countries. Countries were selected to represent diverse socio-economic development levels in the region: Regression analyses were used to assess trends in publications over time and by country...
2017: PloS One
https://www.readbyqxmd.com/read/28559778/magnetic-resonance-imaging-in-hematospermia-does-it-increase-unnecessary-prostate-biopsy
#19
Luke A McGuinness, Samer Obeidat, Christopher Powell
INTRODUCTION: Hematospermia is an uncommon presentation of prostate cancer. Following the introduction of MRI for patients with hematospermia we evaluated its use and effect on prostate biopsy and cancer detection rates. MATERIALS AND METHODS: Analysis of patients attending our outpatient department over 2 years was undertaken. Diagnostic workup included digital rectal examination and PSA. Those with abnormal findings or persisting symptoms were offered prostate biopsy...
April 2017: Current Urology
https://www.readbyqxmd.com/read/28558877/mhealth-for-mental-health-in-the-middle-east-need-technology-use-and-readiness-among-palestinians-in-the-west-bank
#20
Dror Ben-Zeev, Cherie Fathy, Geneva Jonathan, Batoul Abuharb, Rachel M Brian, Lana Kesbeh, Samer Abdelkader
Palestinians in the West Bank are at heightened risk for mental health problems. Limited availability of clinicians and a host of geopolitical, topographical, and infrastructural challenges create significant regional barriers to clinic-based care. The objective of this study was to examine whether mHealth approaches that leverage mobile phones for remote mental health treatment may be viable alternatives. We surveyed 272 Palestinian adults in urban, rural, and refugee camp settings. Most participants (93.4%) reported owning mobile phones...
June 2017: Asian Journal of Psychiatry
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