keyword
MENU ▼
Read by QxMD icon Read
search

Cardiopulmonary interactions

keyword
https://www.readbyqxmd.com/read/29650311/an-object-oriented-computational-model-to-study-cardiopulmonary-hemodynamic-interactions-in-humans
#1
Chuong Ngo, Stephan Dahlmanns, Thomas Vollmer, Berno Misgeld, Steffen Leonhardt
BACKGROUND AND OBJECTIVE: This work introduces an object-oriented computational model to study cardiopulmonary interactions in humans. METHODS: Modeling was performed in object-oriented programing language Matlab Simscape, where model components are connected with each other through physical connections. Constitutive and phenomenological equations of model elements are implemented based on their non-linear pressure-volume or pressure-flow relationship. The model includes more than 30 physiological compartments, which belong either to the cardiovascular or respiratory system...
June 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29608398/a-high-throughput-flow-cytometry-screen-identifies-molecules-that-inhibit-hantavirus-cell-entry
#2
Tione Buranda, Catherine Gineste, Yang Wu, Virginie Bondu, Dominique Perez, Kaylin R Lake, Bruce S Edwards, Larry A Sklar
Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS), which infects more than 200,000 people worldwide. Sin Nombre virus (SNV) and Andes virus (ANDV) cause the most severe form of HCPS, with case fatality ratios of 30%-40%. There are no specific therapies or vaccines for SNV. Using high-throughput flow cytometry, we screened the Prestwick Chemical Library for small-molecule inhibitors of the binding interaction between UV-inactivated and fluorescently labeled SNVR18 particles, and decay-accelerating factor (DAF) expressed on Tanoue B cells...
April 1, 2018: SLAS Discovery
https://www.readbyqxmd.com/read/29593802/oxygen-dependence-of-endothelium-dependent-vasodilation-importance-in-chronic-obstructive-pulmonary-disease
#3
Stefanie Keymel, Benedikt Schueller, Roberto Sansone, Rabea Wagstaff, Stephan Steiner, Malte Kelm, Christian Heiss
Introduction: Epidemiological studies have shown increased morbidity and mortality in patients with coronary artery disease (CAD) and chronic obstructive pulmonary disease (COPD). We aimed to characterize the oxygen dependence of endothelial function in patients with CAD and coexisting COPD. Material and methods: In CAD patients with and without COPD ( n = 33), we non-invasively measured flow-mediated dilation (FMD) and intima-media thickness (IMT) of the brachial artery (BA), forearm blood flow (FBF), and perfusion of the cutaneous microcirculation with laser Doppler perfusion imaging (LDPI)...
March 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29576107/steroids-in-cardiac-surgery-a-systematic-review-and-meta-analysis
#4
REVIEW
N Dvirnik, E P Belley-Cote, H Hanif, P J Devereaux, A Lamy, J M Dieleman, J Vincent, R P Whitlock
BACKGROUND: Cardiopulmonary bypass (CPB) induces a systemic inflammatory reaction that may contribute to postoperative complications. Preventing this reaction with steroids may improve outcomes. We performed a systematic review to evaluate the impact of prophylactic steroids on clinical outcomes in patients undergoing on-pump cardiac surgery. METHODS: We searched MEDLINE, EMBASE, and Cochrane CENTRAL for randomised controlled trials (RCTs) comparing perioperative corticosteroid administration with a control group in adults undergoing CPB...
April 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29573927/stressing-the-cardiopulmonary-vascular-system-the-role-of-echocardiography
#5
REVIEW
Lawrence G Rudski, Luna Gargani, William F Armstrong, Patrizio Lancellotti, Steven J Lester, Ekkehard Grünig, Michele D'Alto, Meriam Åström Aneq, Francesco Ferrara, Rajeev Saggar, Rajan Saggar, Robert Naeije, Eugenio Picano, Nelson B Schiller, Eduardo Bossone
The cardiopulmonary vascular system represents a key determinant of prognosis in several cardiorespiratory diseases. Although right heart catheterization is considered the gold standard for assessing pulmonary hemodynamics, a comprehensive noninvasive evaluation including left and right ventricular reserve and function and cardiopulmonary interactions remains highly attractive. Stress echocardiography is crucial in the evaluation of many cardiac conditions, typically coronary artery disease but also heart failure and valvular heart disease...
March 21, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29573179/towards-robot-assisted-anchor-deployment-in-beating-heart-mitral-valve-surgery
#6
Lingbo Cheng, Mojtaba Sharifi, Mahdi Tavakoli
BACKGROUND: Beating-heart intracardiac surgery promises significant benefits for patients compared with cardiopulmonary bypass based procedures. However, the fast motions of the heart introduce serious challenges for surgeons. METHODS: In this work, a new impedance-controlled master-slave telerobotic system is developed to help perform anchor deployment for mitral valve annuloplasty under the guidance of live ultrasound images of the heart. The proposed bilateral teleoperation system can both reflect the non-oscillatory portion of slave-heart tissue interaction force on the surgeon's hand as haptic feedback and implement rapid compensation for the beating heart's motion...
March 24, 2018: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/29553891/importance-of-comorbidities-in-comatose-survivors-of-shockable-and-non-shockable-out-of-hospital-cardiac-arrest-treated-with-target-temperature-management
#7
Idrees Salam, Jakob Hartvig Thomsen, Jesper Kjaergaard, John Bro-Jeppesen, Martin Frydland, Matilde Winther-Jensen, Lars Køber, Michael Wanscher, Christian Hassager, Helle Søholm
OBJECTIVE: Comorbidity prior to out-of-hospital cardiac arrest (OHCA) and primary rhythm in relation to survival is not well established. We aimed to assess the prognostic importance of comorbidity in relation to primary rhythm in OHCA-patients treated with Target Temperature Management (TTM). DESIGN: Consecutive comatose survivors of OHCA treated with TTM in hospitals in the Copenhagen area between 2002-2011 were included. Utstein-based pre- and in-hospital data collection was performed...
March 19, 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29511564/management-of-patients-with-high-risk-pulmonary-embolism-a-narrative-review
#8
REVIEW
Takeshi Yamamoto
High-risk pulmonary embolism (PE) is a life-threatening disorder associated with high mortality and morbidity. Most deaths in patients with shock occur within the first few hours after presentation, and rapid diagnosis and treatment is therefore essential to save patients' lives. The main manifestations of major PE are acute right ventricular (RV) failure and hypoxia. RV pressure overload is predominantly related to the interaction between the mechanical pulmonary vascular obstruction and the underlying cardiopulmonary status...
2018: Journal of Intensive Care
https://www.readbyqxmd.com/read/29506993/unmeasured-interface-in-emergency-cardiovascular-care-how-do-dispatch-assisted-telephone-cardiopulmonary-resuscitation-and-bystander-training-interact
#9
Audrey L Blewer, Benjamin S Abella
No abstract text is available yet for this article.
March 6, 2018: Circulation
https://www.readbyqxmd.com/read/29485961/cerebral-function-and-perfusion-during-cardiopulmonary-bypass-a-plea-for-a-multimodal-monitoring-approach
#10
Marcus Thudium, Ingo Heinze, Richard K Ellerkmann, Tobias Hilbert
BACKGROUND: Postoperative neurological injury still represents a major cause of morbidity after cardiac surgery. Our objective was to compare the limits as well as advantages of routine monitoring tools for the detection of cerebral function and perfusion deficits during cardiopulmonary bypass in a daily clinical setting. METHODS: Adult patients undergoing elective cardiac surgery with use of cardiopulmonary bypass were included. Patients received monitoring comprising Bispectral Index (BIS), Near Infrared Spectroscopy (NIRS) and assessment of middle cerebral artery flow velocity (MCAV) using transcranial Doppler (TCD) sonography...
January 31, 2018: Heart Surgery Forum
https://www.readbyqxmd.com/read/29484204/the-influence-of-a-full-time-immersive-simulation-based-clinical-placement-on-physiotherapy-student-confidence-during-the-transition-to-clinical-practice
#11
Anthony Wright, Penny Moss, Diane M Dennis, Megan Harrold, Simone Levy, Anne L Furness, Alan Reubenson
Background: Novice students may have limited learning opportunities during their early exposure to complex clinical environments, due to the priorities of patient care. Immersive, high-fidelity simulation provides an opportunity for physiotherapy students to be exposed to relatively complex scenarios in a safe learning environment before transitioning to the clinical setting. The present study evaluated the influence of immersive simulation on student confidence and competence. Methods: Sixty penultimate year physiotherapy students completed an 18-day full-time immersive simulation placement...
2018: Advances in Simulation
https://www.readbyqxmd.com/read/29479919/cardiopulmonary-interactions-with-consecutive-pulmonary-abnormalities-in-patients-with-chronic-heart-failure
#12
REVIEW
Ivan Alerić, Darko Katalinić, Miroslav Krpan
Chronic heart failure places heavy burden on patients, their families and on health care resources, accounting for high numbers of hospital admissions. Despite huge improvements in the treatment of many heart disorders, the clinical syndrome of chronic heart failure as a final pathway of heart pathology is an exception, in that its prevalence is rising, and only small prolongations in survival are occurring. It is associated with high morbidity and poor prognosis, and a survival rate worse than that for some malignant tumors...
September 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29461894/rethinking-chronic-obstructive-pulmonary-disease-chronic-pulmonary-insufficiency-and-combined-cardiopulmonary-insufficiency
#13
R Graham Barr
Almost 70 years ago, Drs. Baldwin, Cournand, and Richards defined chronic pulmonary insufficiency by the presence of respiratory symptoms, radiologic evidence of pulmonary emphysema on chest radiography, and physiologic gas trapping. A decade later, airflow obstruction on spirometry was added to the definition and insufficiency became a disease. Contemporary studies are reviving the diagnostic approach described by these early luminaries, with researchers finding that symptomatic smokers with preserved spirometry have increased exacerbations and that smokers and non-smokers with normal spirometry but emphysema on chest computed tomography have increased mortality...
February 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29455794/effect-of-ventricular-function-and-volumes-on-exercise-capacity-in-adults-with-repaired-tetralogy-of-fallot
#14
Natalia Dłużniewska, Piotr Podolec, Tomasz Miszalski-Jamka, Maciej Krupiński, Paweł Banyś, Małgorzata Urbańczyk, Bogdan Suder, Grzegorz Kopeć, Maria Olszowska, Lidia Tomkiewicz-Pająk
OBJECTIVES: Investigate the effects of left and right ventricular function and severity of pulmonary valve regurgitation, quantified by cardiac magnetic resonance (CMR), on exercise tolerance in adult patients who underwent ToF repair at a young age. METHODS: This is a retrospective cohort study of 52 patients after ToF surgery and 33 age- and sex-matched healthy volunteers. CMR and cardiopulmonary exercise testing (CPET) were performed on all patients; CPET was performed on control subjects...
January 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29452463/autosomal-dominant-mannose-binding-lectin-deficiency-is-associated-with-worse-neurodevelopmental-outcomes-after-cardiac-surgery-in-infants
#15
Daniel Seung Kim, Yatong K Li, Jerry H Kim, Curtis S Bergquist, Marsha Gerdes, Judy C Bernbaum, Nancy Burnham, Donna M McDonald-McGinn, Elaine H Zackai, Susan C Nicolson, Thomas L Spray, Deborah A Nickerson, Hakon Hakonarson, Gail P Jarvik, J William Gaynor
OBJECTIVES: The MBL2 gene is the major genetic determinant of mannose-binding lectin (MBL)-an acute phase reactant. Low MBL levels have been associated with adverse outcomes in preterm infants. The MBL2Gly54Asp missense variant causes autosomal dominant MBL deficiency. We tested the hypothesis that MBL2Gly54Asp is associated with worse neurodevelopmental outcomes after cardiac surgery in neonates. METHODS: This is an analysis of a previously described cohort of patients with nonsyndromic congenital heart disease who underwent cardiac surgery with cardiopulmonary bypass before age 6 months (n = 295)...
March 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29437083/the-fontan-procedure-for-single-ventricle-physiology
#16
Melissa Beaudet Jones
The Fontan procedure is the final procedure in staged palliation for patients with functional single-ventricle physiology. The goal of the procedure is to separate systemic and pulmonary blood flow by directing systemic venous return through the Fontan connection to the pulmonary arteries and the lungs without ventricular contribution. Following the procedure, pulmonary blood flow is completely passive and dependent on pressure gradients, resulting in complex postoperative cardiopulmonary interactions. Understanding the physiology is essential to effectively manage these patients...
February 2018: Critical Care Nurse
https://www.readbyqxmd.com/read/29433335/relationship-between-the-prognostic-value-of-ventilatory-efficiency-and-age-in-patients-with-heart-failure
#17
Yuko Kato, Shinya Suzuki, Tokuhisa Uejima, Hiroaki Semba, Osamu Nagayama, Etsuko Hayama, Takuto Arita, Naoharu Yagi, Hiroto Kano, Shunsuke Matsuno, Takayuki Otsuka, Yuji Oikawa, Takashi Kunihara, Junji Yajima, Takeshi Yamashita
Background Ventilatory efficiency decreases with age. This study aimed to investigate the prognostic significance and cut-off value of the minute ventilation/carbon dioxide production (VE/VCO 2 ) slope according to age in patients with heart failure. Methods and results We analysed 1501 patients with heart failure from our observational cohort who performed maximal symptom-limited cardiopulmonary exercise testing and separated them into three age groups (≤55 years, 56-70 years and ≥71 years) in total and according to the three ejection fraction categories defined by European Society of Cardiology guidelines...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29420059/airway-management-in-athletes-wearing-lacrosse-equipment
#18
Thomas G Bowman, Richard J Boergers, Monica R Lininger
CONTEXT: Patient ventilation volume and rate have been found to be compromised due to the inability to seal a pocket mask over the chinstrap of football helmets. The effects of supraglottic airway devices such as the King LT and of lacrosse helmets on these measures have not been studied. OBJECTIVE: To assess the effects of different airway management devices and helmet conditions on producing quality ventilations while performing cardiopulmonary resuscitation on simulation manikins...
February 8, 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29411336/central-sleep-apnea-with-cheyne-stokes-breathing-in-heart-failure-from-research-to-clinical-practice-and-beyond
#19
K Terziyski, A Draganova
Characterized by periodic crescendo-decrescendo pattern of breathing alternating with central apneas, Central sleep apnea (CSA) with Cheyne-Stokes Breathing represents a highly prevalent, yet underdiagnosed comorbidity in chronic heart failure (CHF). A diverse body of evidence demonstrates increased morbidity and mortality in the presence of CSB. CSB has been described in both CHF patients with preserved and reduced ejection fraction, regardless of drug treatment. Risk factors for CSB are older age, male gender, high BMI, atrial fibrillation and hypocapnia...
February 7, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29409968/regulation-of-vascular-signalling-by-nuclear-sprouty2-in-fetal-lung-epithelial-cells-implications-for-co-ordinated-airway-and-vascular-branching-in-lung-development
#20
David J Walker, Stephen C Land
Sprouty2 (Spry2) acts as a central regulator of tubular growth and branch patterning in the developing mammalian lung by controlling both magnitude and duration of growth factor signalling. To determine if this protein coordinates airway and vascular growth factor signalling, we tested the hypothesis that Spry2 links the primary cue for airway outgrowth, fibroblast growth factor-10 (FGF-10), to genomic events underpinning the expression and release of vascular endothelial growth factor-A (VEGF-A). Using primary fetal distal lung epithelial cells (FDLE) from rat, and immortalised human bronchial epithelial cells (16HBE14o-), we identified a nuclear sub-population of Spry2 which interacted with regions of the rat and human VEGF-A promoter spanning the hypoxia response element (HRE) and adjacent 3' sites...
January 31, 2018: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
keyword
keyword
52749
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"