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Cardiopulmonary interactions

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https://www.readbyqxmd.com/read/29452463/autosomal-dominant-mannose-binding-lectin-deficiency-is-associated-with-worse-neurodevelopmental-outcomes-after-cardiac-surgery-in-infants
#1
Daniel Seung Kim, Yatong K Li, Jerry H Kim, Curtis S Bergquist, Marsha Gerdes, Judy C Bernbaum, Nancy Burnham, Donna M McDonald-McGinn, Elaine H Zackai, Susan C Nicolson, Thomas L Spray, Deborah A Nickerson, Hakon Hakonarson, Gail P Jarvik, J William Gaynor
OBJECTIVES: The MBL2 gene is the major genetic determinant of mannose-binding lectin (MBL)-an acute phase reactant. Low MBL levels have been associated with adverse outcomes in preterm infants. The MBL2 Gly54Asp missense variant causes autosomal dominant MBL deficiency. We tested the hypothesis that MBL2 Gly54Asp is associated with worse neurodevelopmental outcomes after cardiac surgery in neonates. METHODS: This is an analysis of a previously described cohort of patients with nonsyndromic congenital heart disease who underwent cardiac surgery with cardiopulmonary bypass before age 6 months (n = 295)...
March 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29437083/the-fontan-procedure-for-single-ventricle-physiology
#2
Melissa Beaudet Jones
The Fontan procedure is the final procedure in staged palliation for patients with functional single-ventricle physiology. The goal of the procedure is to separate systemic and pulmonary blood flow by directing systemic venous return through the Fontan connection to the pulmonary arteries and the lungs without ventricular contribution. Following the procedure, pulmonary blood flow is completely passive and dependent on pressure gradients, resulting in complex postoperative cardiopulmonary interactions. Understanding the physiology is essential to effectively manage these patients...
February 2018: Critical Care Nurse
https://www.readbyqxmd.com/read/29433335/relationship-between-the-prognostic-value-of-ventilatory-efficiency-and-age-in-patients-with-heart-failure
#3
Yuko Kato, Shinya Suzuki, Tokuhisa Uejima, Hiroaki Semba, Osamu Nagayama, Etsuko Hayama, Takuto Arita, Naoharu Yagi, Hiroto Kano, Shunsuke Matsuno, Takayuki Otsuka, Yuji Oikawa, Takashi Kunihara, Junji Yajima, Takeshi Yamashita
Background Ventilatory efficiency decreases with age. This study aimed to investigate the prognostic significance and cut-off value of the minute ventilation/carbon dioxide production (VE/VCO 2 ) slope according to age in patients with heart failure. Methods and results We analysed 1501 patients with heart failure from our observational cohort who performed maximal symptom-limited cardiopulmonary exercise testing and separated them into three age groups (≤55 years, 56-70 years and ≥71 years) in total and according to the three ejection fraction categories defined by European Society of Cardiology guidelines...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29420059/airway-management-in-athletes-wearing-lacrosse-equipment
#4
Thomas G Bowman, Richard J Boergers, Monica R Lininger
CONTEXT: Patient ventilation volume and rate have been found to be compromised due to the inability to seal a pocket mask over the chinstrap of football helmets. The effects of supraglottic airway devices such as the King LT and of lacrosse helmets on these measures have not been studied. OBJECTIVE: To assess the effects of different airway management devices and helmet conditions on producing quality ventilations while performing cardiopulmonary resuscitation on simulation manikins...
February 8, 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29411336/central-sleep-apnea-with-cheyne-stokes-breathing-in-heart-failure-from-research-to-clinical-practice-and-beyond
#5
K Terziyski, A Draganova
Characterized by periodic crescendo-decrescendo pattern of breathing alternating with central apneas, Central sleep apnea (CSA) with Cheyne-Stokes Breathing represents a highly prevalent, yet underdiagnosed comorbidity in chronic heart failure (CHF). A diverse body of evidence demonstrates increased morbidity and mortality in the presence of CSB. CSB has been described in both CHF patients with preserved and reduced ejection fraction, regardless of drug treatment. Risk factors for CSB are older age, male gender, high BMI, atrial fibrillation and hypocapnia...
February 7, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29409968/regulation-of-vascular-signalling-by-nuclear-sprouty2-in-fetal-lung-epithelial-cells-implications-for-co-ordinated-airway-and-vascular-branching-in-lung-development
#6
David J Walker, Stephen C Land
Sprouty2 (Spry2) acts as a central regulator of tubular growth and branch patterning in the developing mammalian lung by controlling both magnitude and duration of growth factor signalling. To determine if this protein coordinates airway and vascular growth factor signalling, we tested the hypothesis that Spry2 links the primary cue for airway outgrowth, fibroblast growth factor-10 (FGF-10), to genomic events underpinning the expression and release of vascular endothelial growth factor-A (VEGF-A). Using primary fetal distal lung epithelial cells (FDLE) from rat, and immortalised human bronchial epithelial cells (16HBE14o-), we identified a nuclear sub-population of Spry2 which interacted with regions of the rat and human VEGF-A promoter spanning the hypoxia response element (HRE) and adjacent 3' sites...
January 31, 2018: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29407204/dispatcher-assisted-bystander-cardiopulmonary-resuscitation-in-rural-and-urban-areas-and-survival-outcomes-after-out-of-hospital-cardiac-arrest
#7
Jeong Ho Park, Young Sun Ro, Sang Do Shin, Kyoung Jun Song, Ki Jeong Hong, So Yeon Kong
OBJECTIVES: We investigated the impact of dispatcher-assisted bystander cardiopulmonary resuscitation (DA-BCPR) on survival outcomes after out-of-hospital cardiac arrests (OHCAs) that occurred in rural and urban areas. METHODS: This study was a cross-sectional study using nationwide emergency medical services (EMS)-based OHCA registry in Korea. All EMS-treated adults with OHCAs and with presumed cardiac etiology were enrolled between 2012 and 2015, excluding cases witnessed by an EMS provider...
February 1, 2018: Resuscitation
https://www.readbyqxmd.com/read/29404796/continuous-renal-replacement-therapy-with-a-polymethyl-methacrylate-membrane-hemofilter-suppresses-inflammation-in-patients-after-open-heart-surgery-with-cardiopulmonary-bypass
#8
Hiroshi Mukaida, Satoshi Matsushita, Takahiro Inotani, Atsushi Nakamura, Atsushi Amano
Cardiopulmonary bypass (CPB) induces a complex inflammatory response involving an increase in inflammatory cytokines, called postperfusion syndrome. Previous studies demonstrated that adsorption of the serum cytokines can reduce acute inflammation and improve clinical outcomes. In this study, patients were placed on continuous renal replacement therapy (CRRT) with a polymethyl methacrylate (PMMA) membrane hemofilter immediately after the start of an open-heart surgery with CPB and throughout the postoperative course to prevent postperfusion syndrome...
February 5, 2018: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/29374556/ccl5-deficiency-rescues-pulmonary-vascular-dysfunction-and-reverses-pulmonary-hypertension-via-caveolin-1-dependent-bmpr2-activation
#9
Xiaowei Nie, Jianxin Tan, Youai Dai, Yun Liu, Jian Zou, Jie Sun, Shugao Ye, Chenyou Shen, Li Fan, Jingyu Chen, Jin-Song Bian
Pulmonary arterial hypertension (PAH) is a devastating cardiopulmonary disorder characterized by pulmonary arterial remodeling mainly due to excess cellular proliferation and apoptosis resistance of pulmonary arterial smooth muscle cells (PASMCs). Reduced bone morphogenetic protein receptor 2 (BMPR2) expression in patients with PAH impairs pulmonary arterial endothelial cells (PAECs) function. This can adversely affect PAEC survival and promote PASMCs proliferation. We hypothesized that interventions to normalize the expression of genes that are targets of the BMPR2 signaling could restore PAECs function and prevent or reverse PAH...
January 31, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29370924/comparison-of-survival-after-in-hospital-cardiac-arrest-in-patients-with-versus-without-diabetes-mellitus
#10
Justin B Echouffo-Tcheugui, Dhaval Kolte, Sahil Khera, Deepak L Bhatt, Gregg C Fonarow
Diabetes mellitus (DM) increases the risk of sudden cardiac death, but the extent to which it influences survival after an in-hospital cardiac arrest (IHCA) remains unclear. We assessed the association of DM and survival after IHCA. The study included 1,009,073 patients aged ≥18 years who underwent cardiopulmonary resuscitation for IHCA between January 2003 and December 2013, recorded in the Nationwide Inpatient Sample database. The outcomes were survival to hospital discharge and discharge disposition assessed using multivariable logistic regression accounting for relevant covariates and clustering...
December 23, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29352473/the-impact-of-mk-467-on-plasma-drug-concentrations-sedation-and-cardiopulmonary-changes-in-sheep-treated-with-intramuscular-medetomidine-and-atipamezole-for-reversal
#11
M Adam, M R Raekallio, T Keskitalo, J M Honkavaara, M Scheinin, M Kajula, S Mölsä, O M Vainio
The effect of MK-467, a peripheral α2 -adrenoceptor antagonist, on plasma drug concentrations, sedation and cardiopulmonary changes induced by intramuscular (IM) medetomidine was investigated in eight sheep. Additionally, the interactions with atipamezole (ATI) used for reversal were also evaluated. Each animal was treated four times in a randomized prospective crossover design with 2-week washout periods. Medetomidine (MED) 30 μg/kg alone or combined in the same syringe with MK-467 300 μg/kg (MMK) was injected intramuscular, followed by ATI 150 μg/kg (MED + ATI and MMK + ATI) or saline intramuscular 30 min later...
January 19, 2018: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29351473/sympathetically-mediated-cardiac-responses-to-isolated-muscle-metaboreflex-activation-following-exercise-are-modulated-by-body-position-in-humans
#12
André L Teixeira, Mauricio Daher, Mayara Souza, Plinio Santos Ramos, James P Fisher, Lauro C Vianna
Isolated muscle metaboreflex activation with post-handgrip exercise ischemia (PEI) increases sympathetic nerve activity and partially maintains the exercise-induced increase in blood pressure, but a smaller heart rate (HR) response occurs. The cardiopulmonary baroreceptors, mechanically sensitive receptors that respond to changes in central blood volume and pressure, are strongly associated with changes in body position and upon activation elicit reflex sympathoinhibition. Here, we tested the hypothesis that postural changes modulate the sympathetically-mediated cardiac response to PEI in humans...
December 15, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29345541/running-mechanics-and-metabolic-responses-with-water-bottles-and-bottle-belt-holders
#13
Heather K Vincent, Laura A Zdziarski, Kyle Fallgatter, Giorgio Negron, Cong Chen, Trevor Leavitt, MaryBeth Horodyski, Joseph G Wasser, Kevin R Vincent
PURPOSE: This study determined whether differential kinematics, kinetics, rates of energy use and cardiopulmonary responses occurred during running with water bottles and bottle belt holders compared to running only. METHODS: Trained runners (N=42; 27.2±6.4 yr) ran on an instrumented treadmill for four conditions in a randomized order: 1) control run (CON); 2) hand-held full water bottle (FULL, 16.9 fluid oz; 454 g); 3) hand-held half-full water bottle (HALF, 8...
January 18, 2018: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29301459/the-effect-of-ultrafiltration-on-end-cardiopulmonary-bypass-hematocrit-during-cardiac-surgery
#14
Linda Mongero, Alfred Stammers, Eric Tesdahl, Andrew Stasko, Samuel Weinstein
OBJECTIVE: Ultrafiltration (UF) during cardiopulmonary bypass (CPB) is a well-accepted method for hemoconcentration to reduce excess fluid and increase hematocrit, platelet count and plasma constituents. The efficacy of this technique may confer specific benefit to certain patients presenting with acquired cardiac defects. The purpose of this study was to retrospectively evaluate the effect of UF on end-CPB hematocrit by cardiac surgical procedure type. METHODS: A review of 73,506 cardiac procedures from a national registry (SCOPE) was conducted between April 2012 and October 2016 at 197 institutions...
January 1, 2018: Perfusion
https://www.readbyqxmd.com/read/29289346/factors-of-importance-to-30-day-survival-after-in-hospital-cardiac-arrest-in-sweden-a-population-based-register-study-of-more-than-18-000-cases
#15
Fredrik Hessulf, Thomas Karlsson, Peter Lundgren, Solveig Aune, Annelie Strömsöe, Marie-Louise Södersved Källestedt, Therese Djärv, Johan Herlitz, Johan Engdahl
BACKGROUND AND OBJECTIVE: In-hospital cardiac arrest (IHCA) constitutes a major contributor to cardiovascular mortality. The aim of the present study was to investigate factors of importance to 30-day survival after IHCA in Sweden. METHODS: A retrospective register study based on the Swedish Register of Cardiopulmonary Resuscitation (SRCPR) 2006-2015. Sixty-six of 73 hospitals in Sweden participated. The inclusion criterion was a confirmed cardiac arrest in which resuscitation was attempted among patients aged >18years...
December 24, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29251653/static-and-dynamic-balance-performance-and-balance-confidence-in-individuals-with-and-without-pulmonary-arterial-hypertension
#16
Buse Ozcan Kahraman, Ismail Ozsoy, Sema Savci, Serap Acar, Ebru Ozpelit, Can Sevinc, Bahri Akdeniz
PURPOSE: Assessment of balance performance is important for both diagnostic and therapeutic reasons in clinical practice. Although the ideal exercise prescription is unknown for patients with pulmonary arterial hypertension (PAH), balance training may be effective for this population if they have balance impairments, such as other patients with cardiopulmonary diseases. The present study aimed to evaluate static and dynamic balance performance and balance confidence in individuals with and without PAH...
December 14, 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/29236912/cardiorespiratory-performance-of-coronary-artery-disease-patients-on-land-versus-underwater-treadmill-tests-a-comparative-study
#17
Mauricio Koprowski Garcia, Limanara Rizzo, Paulo Yazbek-Júnior, Daniela Yutiyama, Fabiola Jomar da Silva, Denise Matheus, Luiz Eduardo Mastrocolla, Eduardo Massad
OBJECTIVE: To compare responses to a cardiopulmonary exercise test on land versus on an underwater treadmill, to assess the cardiorespiratory performance of coronary artery disease patients while immersed in warm water and to compare with the performance of healthy individuals. METHODS: The sample population consisted of 40 subjects, which included 20 coronary artery disease patients aged 63.7±8.89 years old, functional class I and II, according to the New York Hearth Association, and 20 healthy subjects aged 64...
November 2017: Clinics
https://www.readbyqxmd.com/read/29200138/dispatcher-assisted-cardiopulmonary-resuscitation-program-and-outcomes-after-pediatric-out-of-hospital-cardiac-arrest
#18
Yu Jin Lee, Kyoung Jun Song, Sang Do Shin, Seung Chul Lee, Eui Jung Lee, Young Sun Ro, Ki Ok Ahn
OBJECTIVES: A dispatcher-assisted bystander cardiopulmonary resuscitation (DA-BCPR) is expected to influence the outcomes of pediatric out-of-hospital cardiac arrest (OHCA). Our objective was to measure the effect size of a DA-BCPR on survival outcomes according to location of the event. METHODS: All emergency medical service treated OHCA patients younger than 19 years in Korea from January 2012 through December 2013 were analyzed. Patients with OHCA witnessed by emergency medical service providers and those with missing outcome information were excluded...
December 1, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29199541/impact-of-temperature-on-the-narcotrend-index-during-hypothermic-cardiopulmonary-bypass-in-children-with-sevoflurane-anesthesia
#19
Nils Dennhardt, Christiane Beck, Dietmar Boethig, Sebastian Heiderich, Alexander Horke, Sebastian Tiedge, Martin Boehne, Robert Sümpelmann
BACKGROUND: During cardiopulmonary bypass (CPB) in children, anesthesia maintained by sevoflurane administered via the oxygenator is increasingly common. Anesthetic uptake and requirement may be influenced by the non-physiological conditions during hypothermic CPB. Narcotrend-processed EEG monitoring may, therefore, be useful to guide the administration of sevoflurane during this phase. OBJECTIVE: The objective of this prospective, clinical, observational study was to assess the correlation between body temperature, Narcotrend Index (NI) and administered sevoflurane in children during CPB...
December 1, 2017: Perfusion
https://www.readbyqxmd.com/read/29172364/an-update-on-current-resuscitation-council-uk-guidelines
#20
Sarah L McKernon, Laura Kaura, Kathryn H Taylor, Samantha Reid, Mary C Balmer
On 15 October 2015, The Resuscitation Council (UK) published new resuscitation guidelines following the review of resuscitation science by the International Liaison Committee on Resuscitation (ILCOR). The 2015 guidelines emphasize the importance of interactions between the emergency medical dispatcher, the bystander who provides cardiopulmonary resuscitation (CPR) and the prompt deployment of an automated external defibrillator (AED); the co-ordination of these three elements is crucial to improving out-of-hospital cardiac arrest survival...
April 2017: Dental Update
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