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https://www.readbyqxmd.com/read/28222511/evaluation-of-a-dna-a%C3%AE-42-vaccine-in-aged-nzw-rabbits-antibody-kinetics-and-immune-profile-after-intradermal-immunization-with-full-length-dna-a%C3%AE-42-trimer
#1
Doris Lambracht-Washington, Min Fu, Mary Wight-Carter, Matthew Riegel, Roger N Rosenberg
A pathological hallmark of Alzheimer's disease (AD) are amyloid plaques in the brain consisting of aggregated amyloid-β 42 peptide (Aβ42) derived from cellular amyloid-β protein precursor (AβPP). Based on successful experiments in mouse AD models, active immunization with Aβ42 peptide and passive immunizations with anti-Aβ42 antibodies were started in clinical trials. Active Aβ42 peptide immunization in humans had led to an inflammatory autoimmune response, and the trial was stopped. Passive immunizations had shown some effects in slowing AD pathology...
February 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28222461/elements-for-success-in-managing-type-2-diabetes-with-sglt-2-inhibitors-individualizing-treatment-with-sglt-2-inhibitor-therapy-in-type-2-diabetes-mellitus
#2
Eden M Miller
The largely self-managed nature of type 2 diabetes mellitus (T2DM) underscores the importance of a collaborative decision-making process between patient and provider that best aligns the medication characteristics with the needs, interests, and abilities of the patient and with the treatment goals. The treatment regimen should be kept as simple as possible. This article applies these general principles to the use of sodium glucose cotransporter-2 inhibitor (SGLT-2) therapy, based on evidence from published studies and the clinical experience of the author...
February 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28222402/impact-of-anchor-type-on-porcine-lumbar-biomechanics-finite-element-modelling-and-in-vitro-validation
#3
Martin Brummund, Vladimir Brailovski, Yvan Petit, Yann Facchinello, Jean-Marc Mac-Thiong
BACKGROUND: Rigid posterior implants used for spinal stabilization can be anchored to the vertebrae using pedicle screws or screws combined with transverse process hooks. In the present study, a finite element model of a porcine lumbar spine instrumented with screws and hooks is presented and validated. METHODS: The porcine lumbar spine model was validated using in-vitro measurements on six porcine specimens. Validation metrics included intervertebral rotations (L1 to L6) and nucleus pressure in the topmost cranial instrumented disc...
February 14, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28222381/domain-specific-and-domain-general-processes-underlying-metacognitive-judgments
#4
Lisa M Fitzgerald, Mahnaz Arvaneh, Paul M Dockree
Metacognition and self-awareness are commonly assumed to operate as global capacities. However, there have been few attempts to test this assumption across multiple cognitive domains and metacognitive evaluations. Here, we assessed the covariance between "online" metacognitive processes, as measured by decision confidence judgments in the domains of perception and memory, and error awareness in the domain of attention to action. Previous research investigating metacognition across task domains have not matched stimulus characteristics across tasks raising the possibility that any differences in metacognitive accuracy may be influenced by local task properties...
February 17, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/28222370/increased-postural-sway-in-persons-with-multiple-sclerosis-during-short-term-exposure-to-warm-ambient-temperatures
#5
Paula Y S Poh, Amy N Adams, Mu Huang, Dustin R Allen, Scott L Davis, Anna S Tseng, Craig G Crandall
BACKGROUND: Multiple sclerosis (MS) is a neurological disease marked by demyelination and axonal loss. Individuals with MS experience increases in clinical signs and symptoms during heat exposure. OBJECTIVE: To test the hypothesis that moderate heat exposure adversely affects postural sway in individuals with MS. METHODS: Ten individuals with relapsing-remitting MS (50±8y) and nine controls (47±10y) were examined under a Thermal and a Time Control trial...
February 8, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28222243/studies-on-the-binding-of-modest-modulators-of-the-human-enzyme-sirtuin-6-using-std-nmr
#6
Beatriz E Bolívar, John T Welch
Pyrazinamide (PZA), an essential constituent of short course tuberculosis chemotherapy, binds weakly but selectively to Sirtuin 6 (SIRT6). Despite structural similarities between nicotinamide (NAM), PZA, and pyrazinoic acid (POA), these inhibitors modulate SIRT6 via different mechanisms and binding sites, as suggested by Saturation Transfer Difference (STD) Nuclear Magnetic Resonance (NMR). Available experimental evidence, such as that derived from crystal structures and kinetic experiments, is of only limited utility in the elucidation of the mechanistic details of sirtuin inhibition by NAM or other inhibitors...
February 21, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28222127/unusual-pattern-of-chikungunya-virus-epidemic-in-the-americas-the-panamanian-experience
#7
Jean-Paul Carrera, Yamilka Díaz, Bernardino Denis, Itza Barahona de Mosca, Dennys Rodriguez, Israel Cedeño, Dimelza Arauz, Publio González, Lizbeth Cerezo, Lourdes Moreno, Lourdes García, Lisseth E Sáenz, María Aneth Atencio, Eddy Rojas-Fermin, Fernando Vizcaino, Nicolas Perez, Brechla Moreno, Sandra López-Vergès, Anayansi Valderrama, Blas Armién
BACKGROUND: Chikungunya virus (CHIKV) typically causes explosive epidemics of fever, rash and polyarthralgia after its introduction into naïve populations. Since its introduction in Panama in May of 2014, few autochthonous cases have been reported; most of them were found within limited outbreaks in Panama City in 2014 and Puerto Obaldia town, near the Caribbean border with Colombia in 2015. In order to confirm that Panama had few CHIKV cases compared with neighboring countries, we perform an epidemiological analysis of chikungunya cases reported from May 2014 to July 2015...
February 21, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28222084/african-american-women-s-recollected-experiences-of-adherence-to-breast-cancer-treatment
#8
Sue P Heiney, DeAnne K Hilfinger Messias, Tisha M Felder, Kenneth W Phelps, Jada C Quinn
PURPOSE/OBJECTIVES: To explore African American women's recollected experiences of breast cancer treatment.
. RESEARCH APPROACH: Qualitative description and narrative analysis.
. SETTING: South Carolina Oncology Associates, an outpatient oncology clinic serving rural and urban populations.
. PARTICIPANTS: 16 African American women with breast cancer previously enrolled in the control arm (n = 93) of a completed randomized, controlled trial...
March 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28222083/patients-experiences-with-multiple-myeloma-a-meta-aggregation-of-qualitative-studies
#9
Brynja Hauksdóttir, Marianne E Klinke, Sigríður Gunnarsdóttir, Kristín Björnsdóttir
PROBLEM IDENTIFICATION: To systematically review qualitative evidence regarding patients' experiences of living with multiple myeloma. The main objective was to gain structured understanding of this experience, which is a prerequisite for advancing nursing care and ensuring it is effective.
. LITERATURE SEARCH: Qualitative research articles from January 2005 to March 2016 were located in CINAHL®, PubMed, and Scopus. Supplementary resources were found by scrutinizing reference lists and performing citation tracking...
March 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28222081/oncology-nursing-perceptions-of-patient-electronic-portal-use-a-qualitative-analysis
#10
David E Gerber, Muhammad Shaalan Beg, Tobi Duncan, Mary Gill, Simon J Craddock Lee
PURPOSE/OBJECTIVES: To identify nursing staff reactions to and perceptions of electronic portal use in a cancer setting.
. RESEARCH APPROACH: Qualitative.
. SETTING: Outpatient clinic at the Harold C. Simmons Comprehensive Cancer Center of the University of Texas Southwestern Medical Center in Dallas.
. PARTICIPANTS: 13 nurses with a range of credentials and experience, representing infusion, medical oncology, and bone marrow transplantation clinics...
March 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28221731/identifying-a-conceptual-shift-in-child-and-adolescent-reported-treatment-decision-making-having-a-say-as-i-need-at-this-time
#11
Katherine Patterson Kelly, Catriona Mowbray, Kimberly Pyke-Grimm, Pamela S Hinds
BACKGROUND: Professional organizations and governments recommend child and adolescent involvement in cancer treatment decision making (TDM) despite minimal evidence that children prefer involvement, how best to include them, and the result of doing so. PROCEDURE: Using descriptive qualitative research methods, we interviewed 20 children ages 9-17 years about their TDM preferences and experiences. We shifted our conceptualizations as findings emerged about how children with cancer viewed their decisional experiences...
April 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28221727/docetaxel-bevacizumab-and-gemcitabine-for-very-high-risk-sarcomas-in-adolescents-and-young-adults-a-single-center-experience
#12
Christopher Kuo, Paul M Kent, Antonio D Logan, Karen B Tamulonis, Kristen L Dalton, Marta Batus, Karen Fernandez, Rebecca E Mcfall
BACKGROUND: Adolescent and young adult (AYA) patients with very high risk sarcomas have poor outcomes and are in need of novel therapies. PROCEDURE: From January 2005 to February 2016, we retrospectively identified all AYA patients with relapsed or metastatic high-grade sarcomas, who were treated with at least one cycle of docetaxel (T), bevacizumab (A), and gemcitabine (G) (TAG ; T = 100 mg/m(2) Day 8, A = 15 mg/kg Day 1, G = 1,000 mg/m(2) Days 1 and 8). RESULTS: Fourteen patients, median age of 20 (15-30), received a total of 80 cycles of TAG, and were followed for a median of 83 months...
April 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28221717/cerebral-and-lung-effects-of-a-new-generation-synthetic-surfactant-with-sp-b-and-sp-c-analogs-in-preterm-lambs
#13
Carmen Rey-Santano, Victoria E Mielgo, Xabier Murgia, Miguel Angel Gomez-Solaetxe, Fabrizio Salomone, Federico Bianco, Nicola Pelizzi, Begoña Loureiro, Jon López de Heredia Y Goya
BACKGROUND: Though natural surfactants (SF) are clinically superior to protein-free synthetic preparations, CHF-5633, a synthetic SF containing SP-B and SP-C analog peptides is a potential alternative to natural SF for treating neonatal respiratory distress syndrome (RDS). Nevertheless, information is lacking regarding the safety of this new treatment for the neonatal brain. We sought to compare the cerebral and pulmonary effects of this new synthetic surfactant (CHF5633) with those of natural porcine surfactant (Cursosurf) in premature lambs with RDS...
February 21, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28221367/transcriptomic-analyses-and-leukocyte-telomere-length-measurement-in-subjects-exposed-to-severe-recent-stressful-life-events
#14
N Lopizzo, S Tosato, V Begni, S Tomassi, N Cattane, M Barcella, G Turco, M Ruggeri, M A Riva, C M Pariante, A Cattaneo
Stressful life events occurring in adulthood have been found able to affect mood and behavior, thus increasing the vulnerability for several stress-related psychiatric disorders. However, although there is plenty of clinical data supporting an association between stressful life events in adulthood and an enhanced vulnerability for psychopathology, the underlying molecular mechanisms are still poorly investigated. Thus, in this study we performed peripheral/whole-genome transcriptomic analyses in blood samples obtained from 53 adult subjects characterized for recent stressful life events occurred within the previous 6 months...
February 21, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28221297/optimal-epinephrine-concentration-and-time-delay-to-minimize-perfusion-in-eyelid-surgery-measured-by-laser-based-methods-and-a-novel-form-of-extended-wavelength-diffuse-reflectance-spectroscopy
#15
Rafi Sheikh, Ulf Dahlstrand, Khashayar Memarzadeh, Jonas Blohmé, Nina Reistad, Malin Malmsjö
OBJECTIVE: This study investigates the hypoperfusion effects of epinephrine in local anesthesia in eyelid surgery. A novel form of extended-wavelength diffuse reflectance spectroscopy was evaluated. METHODS: Blood perfusion in porcine eyelid flaps was measured using laser Doppler velocimetry and laser speckle contrast imaging, whereas the tissue response was measured using diffuse reflectance spectroscopy with a broad spectrum (450-1550 nm). Epinephrine was either injected cumulatively, 0...
February 17, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28221214/an-integrative-review-of-psychosocial-concerns-among-young-african-american-breast-cancer-survivors
#16
Timiya S Nolan, Jennifer Frank, Silvia Gisiger-Camata, Karen Meneses
BACKGROUND: African American (AA) women are more likely to be given a diagnosis of breast cancer at an early age, experience morbidity after treatment, and exhibit disparities in survivorship. Although psychosocial well-being is largely studied among breast cancer survivors, data are sparse regarding young AA survivors. OBJECTIVE: This integrative review examined psychosocial concerns in survivorship among young AA survivors using a quality-of-life framework. METHODS: PubMed, CINHAL, EMBASE, PsychINFO, and Scopus were searched for articles exploring psychosocial well-being in young AA survivors...
February 17, 2017: Cancer Nursing
https://www.readbyqxmd.com/read/28221159/what-should-we-do-with-residual-fragments
#17
Kemal Sarica, Emrah Yuruk
OBJECTIVE: To address various issues concerning the fate of residual fragments (and the patients carrying them), their detection, and current and future techniques to avoid them. METHODS: Narrative overview of the all relevant articles retrieved from Pubmed research together with the experiences of personal practice was conducted. RESULTS: Clinically insignificant residual fragments (CIRFs) are defined as asymptomatic, non-obstructing residual fragments smaller than 4 mm (1...
January 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28221072/reflections-on-quagmires-for-clinicians-and-coaches-comment-on-gebhardt-2016
#18
Anthony M Grant
Professional coaching can be considered an example of a postprofessional discipline-a discipline that transcends the traditional boundaries between professional clinical psychology and business consulting and coaching. Not surprisingly, a number of potential quagmires in relation to ethical, educational, and credentialing issues have arisen. However, such tensions present an opportunity to build more solid foundations for the delivery of professional coaching services. A way forward is to more broadly engage with university-level theoretically grounded, coaching-specific educational programs...
February 2017: American Psychologist
https://www.readbyqxmd.com/read/28220929/increasing-the-efficiency-on-producing-radiology-reports-for-breast-cancer-diagnosis-by-means-of-structured-reports-a-comparative-study
#19
J Damian Segrelles, Rosana Medina, Ignacio Blanquer, Luis Martí-Bonmatí
BACKGROUND: Radiology reports are commonly written on free-text using voice recognition devices. Structured reports (SR) have a high potential but they are usually considered more difficult to fill-in so their adoption in clinical practice leads to a lower efficiency. However, some studies have demonstrated that in some cases, producing SRs may require shorter time than plain-text ones. This work focuses on the definition and demonstration of a methodology to evaluate the productivity of software tools for producing radiology reports...
February 21, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28220752/putting-3d-modelling-and-3d-printing-into-practice-virtual-surgery-and-preoperative-planning-to-reconstruct-complex-post-traumatic-skeletal-deformities-and-defects
#20
Kevin Tetsworth, Steve Block, Vaida Glatt
3D printing technology has revolutionized and gradually transformed manufacturing across a broad spectrum of industries, including healthcare. Nowhere is this more apparent than in orthopaedics with many surgeons already incorporating aspects of 3D modelling and virtual procedures into their routine clinical practice. As a more extreme application, patient-specific 3D printed titanium truss cages represent a novel approach for managing the challenge of segmental bone defects. This review illustrates the potential indications of this innovative technique using 3D printed titanium truss cages in conjunction with the Masquelet technique...
2017: SICOT-J
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