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https://www.readbyqxmd.com/read/29242933/arcuate-retinal-nerve-fiber-layer-defect-after-laser-photocoagulation-for-diabetic-macular-edema
#1
Katy C Liu, Manesh Dagli
No abstract text is available yet for this article.
December 14, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29242899/can-probability-maps-of-swept-source-optical-coherence-tomography-predict-visual-field-changes-in-preperimetric-glaucoma
#2
Won June Lee, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
Purpose: To determine the usefulness of swept-source optical coherence tomography (SS-OCT) probability maps in detecting locations with significant reduction in visual field (VF) sensitivity or predicting future VF changes, in patients with classically defined preperimetric glaucoma (PPG). Methods: Of 43 PPG patients, 43 eyes were followed-up on every 6 months for at least 2 years were analyzed in this longitudinal study. The patients underwent wide-field SS-OCT scanning and standard automated perimetry (SAP) at the time of enrollment...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29234440/morinda-officinalis-polysaccharides-stimulate-hypothalamic-gnrh-secretion-in-varicocele-progression
#3
Zhu Zhu, Feng Huang, Feng Wang, Yonghong Zhang, Xiaozhen Zhao, Wei Wang
Varicoceles (VCs) are the predominant cause of male infertility and are a risk factor for chronic venous disease. Morinda officinalis (M. officinalis) is a traditional Chinese medicine used to tonify the kidney and strengthen yang. In this study, we evaluated the effects of water-soluble polysaccharides extracted from M. officinalis (MOPs) on gonadotropin-release hormone (GnRH) secretion in a classic experimental left VC (ELV) rat model. Intragastric administration of MOPs at a dose ranging from 50 mg kg-1 to 100 mg kg-1 facilitated improvements in sperm parameters and seminiferous epithelial structures, modulated serum hormone profiles, and stimulated GnRH synthesis and release in the hypothalamus...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234283/high-fat-diet-decreases-neuronal-activation-in-the-brain-induced-by-resistin-and-leptin
#4
Naif Alsuhaymi, Hamza Habeeballah, Martin J Stebbing, Emilio Badoer
Resistin and leptin are adipokines which act in the brain to regulate metabolic and cardiovascular functions which in some instances are similar, suggesting activation of some common brain pathways. High-fat feeding can reduce the number of activated neurons observed following the central administration of leptin in animals, but the effects on resistin are unknown. The present work compared the distribution of neurons in the brain that are activated by centrally administered resistin, or leptin alone, and, in combination, in rats fed a high fat (HFD) compared to a normal chow diet (ND)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29224968/adjunctive-treatment-with-brexpiprazole-and-escitalopram-reduces-behavioral-stress-responses-and-increase-hypothalamic-npy-immunoreactivity-in-a-rat-model-of-ptsd-like-symptoms
#5
Hagit Cohen, Joseph Zohar, Zeev Kaplan, Jørn Arnt
The study explored effects of brexpiprazole (partial D2/5-HT1A agonist, 5-HT2A and α1B/2C-adrenoceptor antagonist) in rats exposed to predator scent stress (PSS), a proposed model of PTSD-like phenotype. Brexpiprazole (3.0mg/kg, PO), escitalopram (5.0mg/kg, IP) and their combination were administered twice daily for 14 days, starting 14 days after exposure to PSS or sham-PSS, shortly after a situational stress reminder. One day after last treatment behavioral responsivity was assessed. Brexpiprazole+escitalopram-treated rats spent more time in open arms, entered open arms more often and exhibited a lower anxiety index in the elevated plus maze than vehicle-treated, PSS-exposed rats...
December 7, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29222624/dapsone-for-recalcitrant-eosinophilic-annular-erythema-a-case-report-and-literature-review
#6
Luke Wallis, Robert C Gilson, Robert T Gilson
Eosinophilic annular erythema (EAE) is a rare entity of unknown etiology that is possibly related to a hypersensitivity reaction and presents as annular erythematous plaques with tissue eosinophilia. It is classified as a figurate erythema with a controversial relationship to Wells syndrome (WS) in the literature, where it is generally considered a separate entity or subset based on clinical and histopathologic differences. EAE typically presents with recurrent, erythematous, arcuate, and annular plaques on the trunk and proximal extremities...
December 8, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29217488/incomplete-concordance-of-dopamine-transporter-cre-datirescre-mediated-recombination-and-tyrosine-hydroxylase-immunoreactivity-in-the-mouse-forebrain
#7
Siew Hoong Yip, Jade York, Brian Hyland, Stephen J Bunn, David R Grattan
Co-localization of the expression of the dopamine transporter (DAT) with the catecholamine synthesising enzyme tyrosine hydroxylase (TH) has been investigated using transgenic mice expressing Cre recombinase (Cre) dependent green fluorescent protein (GFP) under the control of the DAT promoter (DATIREScre/GFP). Brain sections from adult female mice were stained for Cre-induced GFP and TH using immunohistochemistry, revealing a high degree of co-expression in the midbrain dopaminergic neurons (A8-10) with the exception of the periaqueductal and dorsal raphe nuclei where dual-labelling was notably lower...
December 4, 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29215344/a-new-laparoscopic-manoeuvre-in-median-arcuate-ligament-syndrome
#8
Selçuk Gülmez, Ulaş Aday, Aziz Serkan Senger, Ebubekir Gündeş
No abstract text is available yet for this article.
December 1, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/29214635/kv4-2-channel-activity-controls-intrinsic-firing-dynamics-of-arcuate-kisspeptin-neurons
#9
Philipe R F Mendonça, Victoria Kyle, Shel-Hwa Yeo, William H Colledge, Hugh P C Robinson
Kisspeptin neurons in the hypothalamus are critically involved in reproductive function, via their effect on GnRH neuron activity and consequent gonadotropin release. Kisspeptin neurons show an intrinsic irregularity of firing, but the mechanism of this remains unclear. To address this, we carried out targeted whole-cell patch-clamp recordings of kisspeptin neurons in the arcuate nucleus (Kiss1Arc ), in brain slices isolated from adult male Kiss-Cre:tdTomato mice. Cells fired irregularly in response to constant current stimuli, with a wide range of spike time variability, and prominent subthreshold voltage fluctuations...
December 6, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29209989/pancreaticoduodenal-artery-aneurysms-due-to-median-arcuate-ligament-syndrome-what-we-need-to-know
#10
A Peyrottes, D Mariage, P Baqué, D Massalou
Median arcuate ligament (MAL) syndrome is a rare and poorly known cause of abdominal pain. MAL narrows the celiac artery (CA), resulting in true distal aneurysms, including pancreaticoduodenal artery (PDA) aneurysms. These aneurysms often have an aggressive course, as rupture can result in hemorrhagic shock. CT scan appears to be the most effective investigation for the diagnosis of PDA aneurysms and may reveal possible celiac artery compression. In this series, we describe four cases of PDA aneurysm: two ruptured aneurysms treated by an endovascular procedure and two non-ruptured aneurysms treated by surgery...
December 5, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/29203230/maternal-consumption-of-high-fat-diet-in-mice-alters-hypothalamic-notch-pathway-npy-cell-population-and-food-intake-in-offspring
#11
Simone Ferreira Lemes, Anelise Cristina Parras de Souza, Tanyara Baliani Payolla, Milena Diorio Versutti, Albina de Fátima da Silva Ramalho, Cristiano Mendes-da-Silva, Camilla Mendes Souza, Marciane Milanski, Adriana Souza Torsoni, Marcio Alberto Torsoni
Studies show that maternal consumption of a high-fat diet (HFD) can impair the formation of hypothalamic neuronal circuits in mouse offspring. This damage can be mediated by Notch1/Hes5 signalling activation, leading to repression of proneural factors such as Mash1 and Ngn2/3, which are essential for neuronal differentiation and neurogenesis. Thus, we aimed to investigate the effects of maternal HFD consumption during gestation and lactation on the Notch1/Mash1 pathway in the hypothalamus and arcuate nucleus (ARC) of mouse offspring (neonates and 28 days old)...
December 1, 2017: Neuroscience
https://www.readbyqxmd.com/read/29203206/expression-of-hypothalamic-kisspeptin-neurokinin-b-and-dynorphin-a-neurons-attenuates-in-female-zucker-fatty-rats
#12
Kimihiko Nakao, Kinuyo Iwata, Toshiyuki Takeshita, Hitoshi Ozawa
Zucker fatty (ZF) rats are considered to be an obese model due to leptin receptor abnormality and such rats show infertility. Pulsatile gonadotropin-releasing hormone/luteinizing hormone (LH) secretion, which is important for follicular development in females, is considered to be controlled by KNDy neurons coexpressing kisspeptin, neurokinin B (NKB), and dynorphin A (DynA), encoded by Kiss1, Tac3, and Pdyn, respectively, in the hypothalamic arcuate nucleus (ARC). The purpose of this study is to examine the expression of KNDy neurons in female ZF rats by histochemical approach because pulsatile LH secretion is suppressed...
December 1, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29199095/analysis-of-white-matter-characteristics-with-tract-based-spatial-statistics-according-to-diffusion-tensor-imaging-in-early-parkinson-s-disease
#13
Xiang-Rong Li, Yan-De Ren, Bo Cao, Xuan-Li Huang
OBJECTIVE: To analyze the microstructure of brain white matter according to diffusion tensor imaging (DTI) based on tract-based spatial statistics (TBSS) in early Parkinson's disease (PD). MATERIALS AND METHODS: A total of 31 age- and sex-matched early PD patients and 22 healthy volunteers were recruited in the present study. DTI was performed, and the data analyzed with fsl4.0 software. The fractional anisotropy (FA) was compared between both groups with an independent t test, and the differential area was analyzed...
November 30, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29194516/deficits-in-cortical-suppression-during-vocalization-are-associated-with-structural-abnormalities-in-the-arcuate-fasciculus-in-early-illness-schizophrenia-and-clinical-high-risk-for-psychosis
#14
Thomas J Whitford, Lena K L Oestreich, Judith M Ford, Brian J Roach, Rachel L Loewy, Barbara K Stuart, Daniel H Mathalon
Self-generated speech produces a smaller N1 amplitude in the auditory-evoked potential than externally generated speech; this phenomenon is known as N1-suppression. Schizophrenia patients show less N1-suppression than healthy controls. This failure to self-suppress may underlie patients' characteristic tendency to misattribute self-generated thoughts and actions to external sources. While the cause of N1-suppression deficits to speech in schizophrenia remains unclear, structural damage to the arcuate fasciculus is a candidate, due to its ostensible role in transmitting the efference copy of the motor plan to speak...
November 29, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29189908/diffusion-tractography-reveals-pervasive-asymmetry-of-cerebral-white-matter-tracts-in-the-bottlenose-dolphin-tursiops-truncatus
#15
Alexandra K Wright, Rebecca J Theilmann, Sam H Ridgway, Miriam Scadeng
Brain enlargement is associated with concomitant growth of interneuronal distance, increased conduction time, and reduced neuronal interconnectivity. Recognition of these functional constraints led to the hypothesis that large-brained mammals should exhibit greater structural and functional brain lateralization. As a taxon with the largest brains in the animal kingdom, Cetacea provides a unique opportunity to examine asymmetries of brain structure and function. In the present study, diffusion tensor imaging and tractography were used to investigate cerebral white matter asymmetry in the bottlenose dolphin (Tursiops truncatus)...
November 30, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29188166/tractography-for-optic-radiation-preservation-in-transcortical-approaches-to-intracerebral-lesions
#16
Vijay Agarwal, James G Malcolm, Gustavo Pradilla, Daniel L Barrow
We present a case of intraventricular meningioma resected via a transcortical approach using tractography for optic radiation and arcuate fasciculus preservation. We include a review of the literature. A 54-year-old woman with a history of breast cancer presented with gait imbalance. Workup revealed a mass in the atrium of the left lateral ventricle consistent with a meningioma. Whole brain automated diffusion tensor imaging (DTI) was used to plan a transcortical resection while sparing the optic radiations and arcuate fasciculus...
September 28, 2017: Curēus
https://www.readbyqxmd.com/read/29185149/laparoscopic-treatment-of-median-arcuate-ligament-syndrome-analysis-of-long-term-outcomes-and-predictive-factors
#17
Javier A Cienfuegos, Mateo G Estevez, Miguel Ruiz-Canela, Fernando Pardo, Alberto Diez-Caballero, Isabel Vivas, Jose Ignacio Bilbao, Pablo Martí-Cruchaga, Gabriel Zozaya, Víctor Valentí, José Luis Hernández-Lizoáin, Fernando Rotellar
BACKGROUND: Laparoscopic arcuate ligament release has been demonstrated a valid therapeutic option for arcuate ligament syndrome. Nevertheless, long-term follow-up and predictive factors have not been described for this treatment. METHODS: Clinical and surgical data and short- and long-term outcomes together with the impact of the degree of stenosis of the celiac trunk were analyzed in 13 consecutive patients who underwent laparoscopic arcuate ligament release between 2001 and 2013...
November 28, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29184506/recent-advances-in-the-cellular-and-molecular-mechanisms-of-hypothalamic-neuronal-glucose-detection
#18
Xavier Fioramonti, Chloé Chrétien, Corinne Leloup, Luc Pénicaud
The hypothalamus have been recognized for decades as one of the major brain centers for the control of energy homeostasis. This area contains specialized neurons able to detect changes in nutrients level. Among them, glucose-sensing neurons use glucose as a signaling molecule in addition to its fueling role. In this review we will describe the different sub-populations of glucose-sensing neurons present in the hypothalamus and highlight their nature in terms of neurotransmitter/neuropeptide expression. This review will particularly discuss whether pro-opiomelanocortin (POMC) neurons from the arcuate nucleus are directly glucose-sensing...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29183305/hemodynamic-benefits-of-celiac-artery-release-for-ruptured-right-gastric-artery-aneurysm-associated-with-median-arcuate-ligament-syndrome-a-case-report
#19
Tetsuro Toriumi, Takuro Shirasu, Atsushi Akai, Yuichi Ohashi, Takatoshi Furuya, Yukihiro Nomura
BACKGROUND: It has been reported that median arcuate ligament syndrome is closely associated with gastric or pancreaticoduodenal artery aneurysms. Hemodynamic state plays an important role in the formation of the aneurysms. These aneurysms are treated with open resection or endovascular exclusion. However, whether revascularization of the celiac artery can prevent the aneurysm formation is unknown. This report indicated a possibility that prophylactic revascularization for celiac artery stenosis resulted in decreased shear stress on the collaterals, which may otherwise be susceptible to new aneurysms...
November 28, 2017: BMC Surgery
https://www.readbyqxmd.com/read/29178496/kisspeptin-gnrh-and-er%C3%AE-colocalise-with-nnos-neurones-in-prepubertal-female-sheep
#20
Michelle N Bedenbaugh, Ryan C O'Connell, Justin A Lopez, Richard B McCosh, Robert L Goodman, Stanley M Hileman
Puberty is a process which integrates multiple inputs that ultimately cause an increase in gonadotrophin-releasing hormone (GnRH) secretion. While kisspeptin neurones play an integral role in GnRH secretion and puberty onset, other systems are also likely important. One potential component is nitric oxide (NO), a gaseous neurotransmitter synthesized by nitric oxide synthase (NOS). In this study, we sought to neuroanatomically characterise neuronal NOS (nNOS) in prepubertal female sheep and determine if oestradiol would exert effects on this system...
November 25, 2017: Journal of Neuroendocrinology
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