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Mark A Murakami, Laura Connelly-Smith, Thomas Spitzer, Adetola A Kassim, Sam L Penza, Monzr M Al Malki, James Mason, Chelsa Tourville, Brandon Magliocco, Jacklyn Barten, Hope Guidry-Groves, Jamie Margolis, Steven M Devine, Wolfgang P Rennert, Heather E Stefanski
Data on recent bone marrow harvest collections from the NMDP has shown that bone marrow quality has decreased based on total nucleated cell count in the product. To ensure that quality bone marrow products are available to all recipients, the NMDP Marrow Alliance was formed in April of 2021 to increase the ability for bone marrow collection centers to safely deliver high-quality products consistently and to identify and disseminate guidelines for performing bone marrow harvests. This White Paper describes the best practices of performing a bone marrow harvest as defined by the NMDP Marrow Alliance...
April 18, 2024: Transplantation and cellular therapy
#22
JOURNAL ARTICLE
Ruiping Bai, Rui An, Siyu Chen, Wenkang Ding, Mengwen Xue, Ge Zhao, Qingyong Ma, Xin Shen
AIM: New-onset diabetes mellitus is a frequent and severe complication arising after liver transplantation (LT). We aimed to identify the risk factors for new-onset diabetes mellitus after liver transplantation (NODALT) and to develop a risk prediction score system for relevant risks. METHODS: We collected and analyzed data from all recipients who underwent liver transplantation at the First Affiliated Hospital of Xi'an Jiaotong University. The OR derived from a multiple logistic regression predicting the presence of NODALT was used to calculate the risk prediction score...
April 19, 2024: Journal of Diabetes Investigation
#23
JOURNAL ARTICLE
Zhong-Die Li, Yu-Chuan Li, Jing-Zhao, Jian-She Wang, Xin-Bao Xie
BACKGROUND: Clinical studies on progressive familial intrahepatic cholestasis (PFIC) type 5 caused by mutations in NR1H4 are limited. METHODS: New patients with biallelic NR1H4 variants from our center and all patients from literature were retrospectively analyzed. RESULTS: Three new patients were identified to be carrying five new variants. Liver phenotypes of our patients manifests as low-γ-glutamyl transferase cholestasis, liver failure and related complications...
April 19, 2024: Orphanet Journal of Rare Diseases
#24
JOURNAL ARTICLE
Meihe Li, Xiaojun Hu, Yang Li, Guozhen Chen, Chen-Guang Ding, Xiaohui Tian, Puxun Tian, Heli Xiang, Xiaoming Pan, Xiaoming Ding, Wujun Xue, Jin Zheng, Chenguang Ding
BACKGROUND: Delayed graft function (DGF) is an important complication after kidney transplantation surgery. The present study aimed to develop and validate a nomogram for preoperative prediction of DGF on the basis of clinical and histological risk factors. METHODS: The prediction model was constructed in a development cohort comprising 492 kidney transplant recipients from May 2018 to December 2019. Data regarding donor and recipient characteristics, pre-transplantation biopsy results, and machine perfusion parameters were collected, and univariate analysis was performed...
April 19, 2024: BMC Nephrology
#25
JOURNAL ARTICLE
Glenda M Davison, Jessica J Opie, Saarah F G Davids, Rygana Mohammed, Nicolas Novitzky
BACKGROUND: Allogeneic stem cell transplantation (SCT) is a critical therapy for haematological malignancy but may lead to acute and chronic graft versus host disease (GvHD). T-cell depletion with alemtuzumab, either in vivo or ex vivo, reduces the incidence of GvHD but is a risk factor for disease relapse and poor immune reconstitution. Natural killer (NK) cells are the first lymphocytes to recover. Classical NK cells make up >90% of the normal circulating population and can directly kill neoplastic or virally infected cells while the regulatory subset makes up <10%, secretes cytokines and is not cytotoxic...
April 17, 2024: Transplant Immunology
#26
JOURNAL ARTICLE
Yumiao Lin, Xinxin Li, Jingxian Fang, Qinglan Zeng, Danling Cheng, Gaofeng Wang, Runlu Shi, Yilin Luo, Yihe Ma, Miaomiao Li, Xiang Tang, Xusheng Wang, Ruiyun Tian
Skin, the largest organ of body, is a highly immunogenic tissue with a diverse collection of immune cells. Highly polymorphic human leukocyte antigen (HLA) molecules have a central role in coordinating immune responses as recognition molecules. Nevertheless, HLA gene expression patterns among diverse cell types within a specific organ, like the skin, have yet to be thoroughly investigated, with stromal cells attracting much less attention than immune cells. To illustrate HLA expression profiles across different cell types in the skin, we performed single-cell RNA sequencing (scRNA-seq) analyses on skin datasets, covering adult and fetal skin, and hair follicles as the skin appendages...
April 18, 2024: International Immunopharmacology
#27
JOURNAL ARTICLE
Tun Wang, Peng Lu, Zicheng Wan, Zhenyu He, Siyuan Cheng, Yang Zhou, Sheng Liao, Mo Wang, Tianjian Wang, Chang Shu
Arteriovenous grafts (AVGs) have emerged as the preferred option for constructing hemodialysis access in numerous patients. Clinical trials have demonstrated that decellularized vascular graft exhibits superior patency and excellent biocompatibility compared to polymer materials; however, it still faces challenges such as intimal hyperplasia and luminal dilation. The absence of suitable animal models hinders our ability to describe and explain the pathological phenomena above and in vivo adaptation process of decellularized vascular graft at the molecular level...
2024: Regenerative Biomaterials
#28
JOURNAL ARTICLE
Yongsheng Tang, Zenan Yuan, Xu Lu, Yingqiu Song, Shuguang Zhu, Chunhui Qiu, Qi Zhang, Binsheng Fu, Changchang Jia, Hua Li
BACKGROUND AND AIMS: Hepatic ischemia-reperfusion injury (HIRI) is a prevalent complication of liver transplantation, partial hepatectomy, and severe infection, necessitating the development of more effective clinical strategies. Receptor activity-modifying protein 1 (RAMP1), a member of the G protein-coupled receptor adapter family, has been implicated in numerous physiological and pathological processes. The study aimed to investigate the pathogenesis of RAMP1 in HIRI. METHODS: We established a 70% liver ischemia-reperfusion model in RAMP1 knockout (KO) and wild-type mice...
April 28, 2024: Journal of Clinical and Translational Hepatology
#29
REVIEW
Hao Shi, Yaya Duan, Xinting Bu
Purpose To analyze the factors affecting the mobilization efficiency of hematopoietic stem cells and hematopoietic reconstruction indicators during autologous peripheral hematopoietic stem cell transplantation. Methods The clinical data of 54 patients who underwent autologous peripheral blood hematopoietic stem cell mobilization and transplantation at Xuzhou Central Hospital from May 2016 to April 2023 were retrospectively analyzed. The gender, age, disease type, mobilization regimen, number of chemotherapy sessions, G-CSF (granulocyte colony-stimulating factor) dosage, and platelet number at the time of collection were also collected...
June 2024: Global medical genetics
#30
JOURNAL ARTICLE
Brittany A Boerstra, Rianne Boenink, Megan E Astley, Marjolein Bonthuis, Samar Abd ElHafeez, Federico Arribas Monzón, Anders Åsberg, Pazit Beckerman, Samira Bell, Aleix Cases Amenós, Pablo Castro de la Nuez, Marc A G J Ten Dam, Alicja Debska-Slizien, Nikola Gjorgjievski, Rebecca Giudotti, Jaakko Helve, Kristine Hommel, Alma Idrizi, Ólafur S Indriðason, Faiçal Jarraya, Julia Kerschbaum, Kirill S Komissarov, Nadiia Kozliuk, Milica Kravljaca, Mathilde Lassalle, Johan M De Meester, Mai Ots-Rosenberg, Zoe Plummer, Danilo Radunovic, Olena Razvazhaieva, Halima Resic, Olga Lucía Rodríguez Arévalo, Carmen Santiuste de Pablos, Nurhan Seyahi, María Fernanda Slon-Roblero, Maria Stendahl, Miloreta Tolaj-Avdiu, Sara Trujillo-Alemán, Ieva Ziedina, Edita Ziginskiene, Alberto Ortiz, Kitty J Jager, Vianda S Stel, Anneke Kramer
BACKGROUND: The European Renal Association (ERA) Registry collects data on kidney replacement therapy (KRT) in patients with end-stage kidney disease (ESKD). This paper is a summary of the ERA Registry Annual Report 2021, including a comparison across treatment modalities. METHODS: Data was collected from 54 national and regional registries from 36 countries, of which 35 registries from 18 countries contributed individual patient data and 19 registries from 19 countries contributed aggregated data...
February 2024: Clinical Kidney Journal
#31
JOURNAL ARTICLE
Lisette A P Krassenburg, Raoel Maan, Amy Puenpatom, Nicole S Erler, Christoph Welsch, Stijn van Hees, Orlando Cerrhoci, Johannes Vermehren, Robert J de Knegt, Bettina E Hansen, Stefan Zeuzem, Thomas Vanwolleghem, Harry L A Janssen, Robert A de Man, Jordan J Feld, Adriaan J van der Meer
BACKGROUND AND AIMS: Historical paired liver biopsy studies are likely to underestimate current progression of disease in patients with chronic hepatitis C virus (HCV) infection. We aimed to assess liver disease progression according to the non-invasive Fibrosis-4 (FIB-4) index in patients with chronic HCV and early disease. METHODS AND RESULTS: Patients diagnosed with chronic HCV and FIB-4 <3.25 from four international liver clinics were included in a retrospective cohort study...
December 7, 2023: BMJ Open Gastroenterology
#32
JOURNAL ARTICLE
Shanhui Liu, Kanak Joshi, Lei Zhang, Wenyan Li, Ryan Mack, Austin Runde, Patrick A Hagen, Kevin Barton, Peter Breslin, Hong-Long Ji, Ameet R Kini, Zhiping Wang, Jiwang Zhang
Myelodysplastic syndromes (MDS) are a heterogeneous group of pre-leukemic hematopoietic disorders characterized by cytopenia in peripheral blood due to ineffective hematopoiesis and normo- or hypercellularity and morphologic dysplasia in bone marrow (BM). An inflammatory BM microenvironment and programmed cell death of hematopoietic stem/progenitor cells (HSPCs) are thought to be the major causes of ineffective hematopoiesis in MDS. Pyroptosis, apoptosis and necroptosis (collectively, PANoptosis) are observed in BM tissues of MDS patients, suggesting an important role of PANoptosis in MDS pathogenesis...
April 18, 2024: Cell Death & Disease
#33
JOURNAL ARTICLE
Tung-Ling Chung, Nai-Ching Chen, Chun-Hao Yin, Ching-Chih Lee, Chien-Liang Chen
BACKGROUND: Conflicting evidence exists regarding the relationship between socioeconomic status and access to or outcomes after kidney transplantation. This study analyzed the effects of individual and neighborhood socioeconomic status on kidney transplant access and outcomes in Taiwan. METHODS: We used a retrospective cohort study design and performed comparisons using the Cox proportional hazards model after adjusting for risk factors. Data were collected from the National Health Insurance Bureau of Taiwan data (2003-2012)...
April 18, 2024: Journal of Nephrology
#34
JOURNAL ARTICLE
Rocío Navas Huerga, Isabel Salcedo de Diego, Carlos de Miguel Jiménez, Cristina Muñoz Martínez, Mi Kwon, Natalia Pedraza García, María Calbacho, Ana Royuela Vicente, Pilar Serrano Gallardo
PURPOSE: Financial toxicity (FT) refers to the subjective perception of financial distress resulting from objective economic strain due to illness, exerting a detrimental influence on health outcomes. This study aimed to describe FT among allogeneic haematopoietic stem cell transplant (allo-HSCT) recipients within a public health framework, employing a social determinants of health approach. METHODS: A multi-centre cross-sectional study involving adult allo-HSCT patients was conducted across three public hospitals in Madrid...
April 8, 2024: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
#35
JOURNAL ARTICLE
Thaysa Sobral Antonelli, Milena Dos Santos Mantovani, Nyara Coelho de Carvalho, Thomáz Eduardo Archangelo, Marcos Ferreira Minicucci, Sebastião Pires Ferreira Filho, Ricardo de Souza Cavalcante, Luis Gustavo Modelli de Andrade, Nara Aline Costa, Paulo Roberto Kawano, Gabriel Berg de Almeida, Silvia Justina Papini, Ricardo Augusto Monteiro de Barros Almeida
BACKGROUND: The association between obesity and infectious diseases is increasingly reported in the literature. There are scarce studies on the association between obesity and urinary tract infection after kidney transplantation (KTx). These studies defined obesity based on body mass index, and their results were conflicting. The present study aimed to evaluate this association using bioelectrical impedance analysis for body composition evaluation, and obesity definition. METHODS: A single-center cohort study was conducted...
April 17, 2024: Journal of Nephrology
#36
REVIEW
Lauren Dietz, Jessica Marini, Hamza Hashmi, Mary McGann
High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation is the standard of care for eligible patients with newly diagnosed multiple myeloma leading to prolonged progression free and overall survival. Successful engraftment following hematopoietic stem cell infusion requires adequate stem cell doses. Current mobilization regimens include granulocyte colony-stimulating factor (G-CSF) with or without plerixafor. Motixafortide is a recently approved agent that can be used in combination with G-CSF for mobilization...
April 17, 2024: Journal of Oncology Pharmacy Practice
#37
JOURNAL ARTICLE
Omosomi Enilama, Cynthia MacDonald, Pearl Thompson, Umair Khan, Selina Allu, Mary Beaucage, Kevin Yau, Matthew J Oliver, Michelle A Hladunewich, Adeera Levin
BACKGROUND: People living with chronic kidney disease (CKD) face an increased risk of severe outcomes such as hospitalization or death from COVID-19. COVID-19 vaccination is a vital approach to mitigate the risk and severity of infection in patients with CKD. Limited information exists regarding the factors that shape COVID-19 vaccine uptake, including health information-seeking behavior and perceptions, within the CKD population. OBJECTIVE: The objectives were to describe among CKD patients, (1) health information-seeking behavior on COVID-19, (2) their capacity to comprehend and trust COVID-19 information from different sources, and (3) their perceptions concerning COVID-19 infection and vaccination...
2024: Canadian Journal of Kidney Health and Disease
#38
JOURNAL ARTICLE
Vishal C Patel, Mark J McPhail, Ruhama Uddin, Hassan Jafari, Vanessa Lawrence, Clair Le Boutillier, James Shearer, Nahel Yaziji, Angela Cape, Haroon Ahmed, Christopher Ward, Peter Walsh, Kevin Besly, Ane Zamalloa, Joanna Kelly, Ben Carter
BACKGROUND: Liver disease is within the top five causes of premature death in adults. Deaths caused by complications of cirrhosis continue to rise, whilst deaths related to other non-liver disease areas are declining. Portal hypertension is the primary sequelae of cirrhosis and is associated with the development of variceal haemorrhage, ascites, hepatic encephalopathy and infection, collectively termed hepatic decompensation, which leads to hospitalisation and mortality. It remains uncertain whether administering a non-selective beta-blocker (NSBB), specifically carvedilol, at an earlier stage, i...
April 16, 2024: Trials
#39
JOURNAL ARTICLE
Tong Wu, Yangyang Wu, Kebing Nie, Jinfeng Yan, Ying Chen, Shixuan Wang, Jinjin Zhang
AIM: The purpose of this study was to characterize publication patterns, academic influence, research trends, and the recent developments in uterus transplantation (UTx) across the globe. METHODS: The Web of Science Core Collection database was searched for documents published from the time the database began to include relevant articles to December 15, 2023. With the use of VOSviewer, Citespace, BICOMB, and Incites, a cross-sectional bibliometric analysis was conducted to extract or calculate the evaluative indexes...
April 17, 2024: International Journal of Surgery
#40
JOURNAL ARTICLE
Valentin Goutaudier, Marta Sablik, Maud Racapé, Olivia Rousseau, Benoit Audry, Nassim Kamar, Marc Raynaud, Olivier Aubert, Béatrice Charreau, Emmanuelle Papuchon, Richard Danger, Laurence Letertre, Lionel Couzi, Emmanuel Morelon, Moglie Le Quintrec, Jean-Luc Taupin, Eric Vicaut, Christophe Legendre, Hoa Le Mai, Vishnu Potluri, Thi-Van-Ha Nguyen, Marie-Eliane Azoury, Alice Pinheiro, Georges Nouadje, Pierre Sonigo, Dany Anglicheau, Ineke Tieken, Serge Vogelaar, Christian Jacquelinet, Peter Reese, Pierre-Antoine Gourraud, Sophie Brouard, Carmen Lefaucheur, Alexandre Loupy
There is an unmet need for robust and clinically validated biomarkers of kidney allograft rejection. Here we present the KTD-Innov study (ClinicalTrials.gov, NCT03582436), an unselected deeply phenotyped cohort of kidney transplant recipients with a holistic approach to validate the clinical utility of precision diagnostic biomarkers. In 2018-2019, we prospectively enrolled consecutive adult patients who received a kidney allograft at seven French centers and followed them for a year. We performed multimodal phenotyping at follow-up visits, by collecting clinical, biological, immunological, and histological parameters, and analyzing a panel of 147 blood, urinary and kidney tissue biomarkers...
April 16, 2024: European Journal of Epidemiology
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