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Gap junction intercellular communication

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https://www.readbyqxmd.com/read/29146153/the-stress-kinase-jnk-regulates-gap-junction-cx43-gene-expression-and-promotes-atrial-fibrillation-in-the-aged-heart
#1
Jiajie Yan, Justin K Thomson, Weiwei Zhao, Xiaomin Wu, Xianlong Gao, Dominic DeMarco, Wei Kong, Min Tong, Jun Sun, Mamdouh Bakhos, Vladimir G Fast, Qingrong Liang, Sumanth D Prabhu, Xun Ai
BACKGROUND: The stress kinase c-jun N-terminal kinase (JNK) is critical in the pathogenesis of cardiac diseases associated with an increased incidence of atrial fibrillation (AF), the most common arrhythmia in the elderly. We recently discovered that JNK activation is linked to the loss of gap junction connexin43 (Cx43) and enhanced atrial arrhythmogenicity. However, direct evidence for JNK-mediated impairment of intercellular coupling (cell-cell communication) in the intact aged atrium is lacking, as is evidence for whether and how JNK suppresses Cx43 in the aged human atrium...
November 13, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29143796/angelica-sinensis-polysaccharides-ameliorate-stress-induced-premature-senescence-of-hematopoietic-cell-via-protecting-bone-marrow-stromal-cells-from-oxidative-injuries-caused-by-5-fluorouracil
#2
Hanxianzhi Xiao, Lirong Xiong, Xiaoying Song, Pengwei Jin, Linbo Chen, Xiongbin Chen, Hui Yao, Yaping Wang, Lu Wang
Myelosuppression is the most common complication of chemotherapy. Decline of self-renewal capacity and stress-induced premature senescence (SIPS) of hematopoietic stem cells (HSCs) induced by chemotherapeutic agents may be the cause of long-term myelosuppression after chemotherapy. Whether the mechanism of SIPS of hematopoietic cells relates to chemotherapeutic injury occurred in hematopoietic microenvironment (HM) is still not well elucidated. This study explored the protective effect of Angelica sinensis polysaccharide (ASP), an acetone extract polysaccharide found as the major effective ingredients of a traditional Chinese medicinal herb named Chinese Angelica (Dong Quai), on oxidative damage of homo sapiens bone marrow/stroma cell line (HS-5) caused by 5-fluorouracil (5-FU), and the effect of ASP relieving oxidative stress in HM on SIPS of hematopoietic cells...
October 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29132390/a-transwell-assay-that-excludes-exosomes-for-assessment-of-tunneling-nanotube-mediated-intercellular-communication
#3
Venugopal Thayanithy, Patrick O'Hare, Phillip Wong, Xianda Zhao, Clifford J Steer, Subbaya Subramanian, Emil Lou
BACKGROUND: Tunneling nanotubes (TNTs) are naturally-occurring filamentous actin-based membranous extensions that form across a wide spectrum of mammalian cell types to facilitate long-range intercellular communication. Valid assays are needed to accurately assess the downstream effects of TNT-mediated transfer of cellular signals in vitro. We recently reported a modified transwell assay system designed to test the effects of intercellular transfer of a therapeutic oncolytic virus, and viral-activated drugs, between cells via TNTs...
November 13, 2017: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/29126985/spatiotemporal-expression-pattern-of-connexin-43-during-early-chick-embryogenesis
#4
Karyn Jourdeuil, Lisa A Taneyhill
During embryogenesis, a single cell develops into new tissues and organs that are made up of a number of different cell types. The assembly of the trigeminal ganglion (cranial nerve V), an important component of the peripheral nervous system, typifies this process. The trigeminal ganglia perform key sensory functions, including sensing pain and touch in the face, and arise from cells of two different progenitor populations, the neural crest and the cranial placodes. One question that remains poorly understood is how these two populations of cells interact with each other during development to form a functional ganglion...
November 7, 2017: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/29115581/tramadol-attenuates-the-sensitivity-of-glioblastoma-to-temozolomide-through-the-suppression-of-cx43%C3%A2-mediated-gap-junction-intercellular-communication
#5
Lingzhi Wang, Yuexia Peng, Jianxin Peng, Min Shao, Li Ma, Zhuoli Zhu, Guocheng Zhong, Zhengyuan Xia, Huansen Huang
Analgesics and antineoplastic drugs are often used concurrently for cancer patients. Our previous study reported that gap junctions composed of connexin32 (Cx32) was implicated in the effect of analgesics on cisplatin cytotoxicity. However, the effect of analgesic on the most widely expressed connexin (Cx), connexin43 (Cx43), and whether such effect mediates the influence on chemotherapeutic efficiency remain unknown. By manipulation of Cx43 expression or gap junction function, we found that there were gap junction-dependent and independent effect of Cx43 on temozolomide (TMZ) sensitivity in U87 glioblastoma cells...
November 3, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29101030/the-alpha2-adrenoreceptor-agonist-dexmedetomidine-protects-against-lipopolysaccharide-induced-apoptosis-via-inhibition-of-gap-junctions-in-lung-fibroblasts
#6
Yuan Zhang, Xiaoming Tan, Lianfang Xue
The α2-adrenoceptor inducer dexmedetomidine protects against acute lung injury (ALI), but the mechanism of this effect is largely unknown. The present study investigated the effect of dexmedetomidine on apoptosis induced by lipopolysaccharide (LPS) and the relationship between this effect and gap junction intercellular communication in human lung fibroblast cell line. Flow cytometry was used to detect apoptosis induced by LPS. Parachute dye coupling assay was used to measure gap junction function, and western blot analysis was used to determine the expression levels of connexin43 (Cx43)...
October 31, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29089870/tunneling-nanotubes-and-gap-junctions-their-role-in-long-range-intercellular-communication-during-development-health-and-disease-conditions
#7
REVIEW
Jennifer Ariazi, Andrew Benowitz, Vern De Biasi, Monique L Den Boer, Stephanie Cherqui, Haifeng Cui, Nathalie Douillet, Eliseo A Eugenin, David Favre, Spencer Goodman, Karine Gousset, Dorit Hanein, David I Israel, Shunsuke Kimura, Robert B Kirkpatrick, Nastaran Kuhn, Claire Jeong, Emil Lou, Robbie Mailliard, Stephen Maio, George Okafo, Matthias Osswald, Jennifer Pasquier, Roel Polak, Gabriele Pradel, Bob de Rooij, Peter Schaeffer, Vytenis A Skeberdis, Ian F Smith, Ahmad Tanveer, Niels Volkmann, Zhenhua Wu, Chiara Zurzolo
Cell-to-cell communication is essential for the organization, coordination, and development of cellular networks and multi-cellular systems. Intercellular communication is mediated by soluble factors (including growth factors, neurotransmitters, and cytokines/chemokines), gap junctions, exosomes and recently described tunneling nanotubes (TNTs). It is unknown whether a combination of these communication mechanisms such as TNTs and gap junctions may be important, but further research is required. TNTs are long cytoplasmic bridges that enable long-range, directed communication between connected cells...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29065929/vegf-promotes-endothelial-progenitor-cell-differentiation-and-vascular-repair-through-connexin-43
#8
Lufeng Li, Huanyun Liu, Chunxin Xu, Mengyang Deng, Mingbao Song, Xuejun Yu, Shangcheng Xu, Xiaohui Zhao
BACKGROUND: Endothelial progenitor cell (EPC) differentiation is considered crucial for vascular repair. Vascular endothelial growth factor (VEGF) induces EPC differentiation, but the underlying mechanism of this phenomenon remains unclear. Connexin 43 (Cx43) is reported to be involved in the regulation of stem cell differentiation. Therefore, we sought to determine whether Cx43 is involved in VEGF-induced EPC differentiation and vascular repair. METHODS: Rat spleen-derived EPCs were cultured and treated with various concentrations of VEGF (0, 10, or 50 ng/mL), and the relationship between EPC differentiation and Cx43 expression was evaluated...
October 24, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29036409/structure-of-an-innexin-gap-junction-channel-and-cryo-em-sample-preparation
#9
Atsunori Oshima
Gap junction channels are essential for mediating intercellular communication in most multicellular organisms. Two gene families encode gap junction channels, innexin and connexin. Although the sequence similarity between these two families based on bioinformatics is not conclusively determined, the gap junction channels encoded by these two gene families are structurally and functionally analogous. We recently reported an atomic structure of an invertebrate innexin gap junction channel using single-particle cryo-electron microscopy...
September 21, 2017: Microscopy
https://www.readbyqxmd.com/read/29030562/astrocyte-calcium-waves-propagate-proximally-by-gap-junction-and-distally-by-extracellular-diffusion-of-atp-released-from-volume-regulated-anion-channels
#10
Yuki Fujii, Shohei Maekawa, Mitsuhiro Morita
Wave-like propagation of [Ca(2+)]i increases is a remarkable intercellular communication characteristic in astrocyte networks, intercalating neural circuits and vasculature. Mechanically-induced [Ca(2+)]i increases and their subsequent propagation to neighboring astrocytes in culture is a classical model of astrocyte calcium wave and is known to be mediated by gap junction and extracellular ATP, but the role of each pathway remains unclear. Pharmacologic analysis of time-dependent distribution of [Ca(2+)]i revealed three distinct [Ca(2+)]i increases, the largest being in stimulated cells independent of extracellular Ca(2+) and inositol 1,4,5-trisphosphate-induced Ca(2+) release...
October 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29025971/role-of-connexin-43-in-different-forms-of-intercellular-communication-gap-junctions-extracellular-vesicles-and-tunnelling-nanotubes
#11
REVIEW
Teresa M Ribeiro-Rodrigues, Tânia Martins-Marques, Sandrine Morel, Brenda R Kwak, Henrique Girão
Communication is important to ensure the correct and efficient flow of information, which is required to sustain active social networks. A fine-tuned communication between cells is vital to maintain the homeostasis and function of multicellular or unicellular organisms in a community environment. Although there are different levels of complexity, intercellular communication, in prokaryotes to mammalians, can occur through secreted molecules (either soluble or encapsulated in vesicles), tubular structures connecting close cells or intercellular channels that link the cytoplasm of adjacent cells...
October 12, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/29025706/no-augments-endothelial-reactivity-by-reducing-myoendothelial-calcium-signal-spreading-a-novel-role-for-cx37-connexin-37-and-shp-2
#12
Kristin Pogoda, Hanna Mannell, Stephanie Blodow, Holger Schneider, Kai Michael Schubert, Jiehua Qiu, Andreas Schmidt, Axel Imhof, Heike Beck, Laurentia Irina Tanase, Alexander Pfeifer, Ulrich Pohl, Petra Kameritsch
OBJECTIVE: Because of its strategic position between endothelial and smooth muscle cells in microvessels, Cx37 (Connexin 37) plays an important role in myoendothelial gap junctional intercellular communication. We have shown before that NO inhibits gap junctional intercellular communication through gap junctions containing Cx37. However, the underlying mechanism is not yet identified. APPROACH AND RESULTS: Using channel-forming Cx37 mutants exhibiting partial deletions or amino acid exchanges in their C-terminal loops, we now show that the phosphorylation state of a tyrosine residue at position 332 (Y332) in the C terminus of Cx37 controls the gap junction-dependent spread of calcium signals...
October 12, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29022008/inflammatory-activation-of-human-cardiac-fibroblasts-leads-to-altered-calcium-signaling-decreased-connexin-43-expression-and-increased-glutamate-secretion
#13
Eva Skiöldebrand, Annika Lundqvist, Ulrika Björklund, Mikael Sandstedt, Anders Lindahl, Elisabeth Hansson, Lillemor Mattsson Hultén
Cardiac fibroblasts, which are abundant in heart tissue, are involved not only in extracellular matrix homeostasis and repair, but also in cardiac remodeling after a myocardial infarction that, in turn, can lead to loss of cardiac function and heart failure. Ca(2+) signaling is functionally important in many cell types, but the roles of fibroblast signaling and inflammation in the pathogenesis of heart disease are unclear. Here, we tested the hypothesis that inflammatory activation affects cardiac fibroblasts, both in terms of Ca(2+) signaling and their capacity for intercellular communication through the gap junction channel protein connexin 43 (Cx43)...
October 2017: Heliyon
https://www.readbyqxmd.com/read/29017810/redox-mediated-regulation-of-connexin-proteins-focus-on-nitric-oxide
#14
REVIEW
Isaac E García, Helmuth A Sánchez, Agustín D Martínez, Mauricio A Retamal
Connexins are membrane proteins that form hemichannels and gap junction channels at the plasma membrane. Through these channels connexins participate in autocrine and paracrine intercellular communication. Connexin-based channels are tightly regulated by membrane potential, phosphorylation, pH, redox potential, and divalent cations, among others, and the imbalance of this regulation have been linked to many acquired and genetic diseases. Concerning the redox potential regulation, the nitric oxide (NO) has been described as a modulator of the hemichannels and gap junction channels properties...
October 7, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28983585/complex-role-of-connexin-43-in-astrocytic-tumors-and-possible-promotion-of-glioma%C3%A2-associated-epileptic-discharge-review
#15
Hui Dong, Xing-Wang Zhou, Xiang Wang, Yuan Yang, Jie-Wen Luo, Yan-Hui Liu, Qing Mao
Connexin (Cx)43 is a multifunction protein which forms gap junction channels and hemi‑channels. It also contains abundant binding domains which possess the ability to interact with certain Cx43‑associated proteins and therefore serve a fundamental role in various physiological and pathological functions. However, the understanding of the association between cancer and Cx43 along with Cx43‑gap junctions (GJ) remains unclear. All available data illustrate that Cx43 and its associated GJ serve important functions in cancers...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28931622/connexins-in-cardiovascular-and-neurovascular-health-and-disease-pharmacological-implications
#16
REVIEW
Luc Leybaert, Paul D Lampe, Stefan Dhein, Brenda R Kwak, Peter Ferdinandy, Eric C Beyer, Dale W Laird, Christian C Naus, Colin R Green, Rainer Schulz
Connexins are ubiquitous channel forming proteins that assemble as plasma membrane hemichannels and as intercellular gap junction channels that directly connect cells. In the heart, gap junction channels electrically connect myocytes and specialized conductive tissues to coordinate the atrial and ventricular contraction/relaxation cycles and pump function. In blood vessels, these channels facilitate long-distance endothelial cell communication, synchronize smooth muscle cell contraction, and support endothelial-smooth muscle cell communication...
October 2017: Pharmacological Reviews
https://www.readbyqxmd.com/read/28919895/mind-the-gaps-in-tumor-immunity-impact-of-connexin-mediated-intercellular-connections
#17
REVIEW
María Alejandra Gleisner, Mariela Navarrete, Francisca Hofmann, Flavio Salazar-Onfray, Andrés Tittarelli
Gap junctions (GJs)-mediated intercellular communications (GJICs) are connexin (Cx)-formed plasma membrane channels that allow for the passage of small molecules between adjacent cells, and are involved in several physiopathological processes, including immune responses against cancer. In general, tumor cells are poorly coupled through GJs, mainly due to low Cx expression or reduced channel activity, suggesting that Cxs may have tumor suppressor roles. However, more recent data indicate that Cxs and/or GJICs may also in some cases promote tumor progression...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28902343/connexin%C3%A2-43-in-the-development-and-progression-of-breast-cancer-what-s-the-connection-review
#18
Stephanie L Phillips, Carly Bess Williams, Joelle N Zambrano, Christina J Williams, Elizabeth S Yeh
Connexin 43 is a prominent gap junction protein within normal human breast tissue. Thus far, there have been a number of research studies performed to determine the function of connexin 43 in breast tumor formation and progression. Within primary tumors, research suggests that the level of connexin 43 expression in breast tumors is altered when compared to normal human breast tissue. While some reports indicate that connexin 43 levels decrease, other evidence suggests that connexin 43 levels are increased and protein localization shifts from the plasma membrane to the cytoplasm...
October 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28892263/regulation-of-germ-cell-development-by-intercellular-signaling-in-the-mammalian-ovarian-follicle
#19
REVIEW
Hugh J Clarke
Prior to ovulation, the mammalian oocyte undergoes a process of differentiation within the ovarian follicle that confers on it the ability to give rise to an embryo. Differentiation comprises two phases-growth, during which the oocyte increases more than 100-fold in volume as it accumulates macromolecules and organelles that will sustain early embryogenesis; and meiotic maturation, during which the oocyte executes the first meiotic division and prepares for the second division. Entry of an oocyte into the growth phase appears to be triggered when the adjacent granulosa cells produce specific growth factors...
September 11, 2017: Wiley Interdisciplinary Reviews. Developmental Biology
https://www.readbyqxmd.com/read/28888046/gap-junctional-intercellular-communication-in-adipose-derived-stromal-stem-cells-is-cell-density-dependent-and-positively-impacts-adipogenic-differentiation
#20
Miriam Wiesner, Oliver Berberich, Christiane Hoefner, Torsten Blunk, Petra Bauer-Kreisel
Adipose-derived stromal/stem cells (ASCs) represent a widely used cell source with multi-lineage differentiation capacity in approaches for tissue engineering and regenerative medicine. Despite the multitude of literature on their differentiation capacity, little is reported about the physiological properties contributing to and controlling the process of lineage differentiation. Direct intercellular communication between adjacent cells via gap junctions has been shown to modulate differentiation processes in other cell types, with connexin 43 (Cx43) being the most abundant isoform of the gap junction-forming connexins...
September 9, 2017: Journal of Cellular Physiology
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