keyword
MENU ▼
Read by QxMD icon Read
search

Glycated albumin

keyword
https://www.readbyqxmd.com/read/28090231/effects-of-ipragliflozin-on-diabetic-nephropathy-and-blood-pressure-in-patients-with-type-2-diabetes-an-open-label-study
#1
Daisuke Ito, Emi Ikuma-Suwa, Kazuyuki Inoue, Kimie Kaneko, Morifumi Yanagisawa, Kouichi Inukai, Mitsuhiko Noda, Akira Shimada
BACKGROUND: Sodium-glucose cotransporter 2 (SGLT2) inhibitors are novel agents used to treat type 2 diabetic patients. We investigated the efficacy of the SGLT2 inhibitor ipragliflozin on diabetic nephropathy in Japanese patients with type 2 diabetes. METHODS: A 50 mg dose of ipragliflozin was administered for 24 weeks to 50 patients with type 2 diabetes who were concomitantly managed with diet and exercise therapy alone or antidiabetic medications other than SGLT2 inhibitors...
February 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28076482/correlation-of-non-alcoholic-fatty-liver-disease-and-features-of-metabolic-syndrome-in-morbidly-obese-patients-in-the-preoperative-assessment-for-bariatric-surgery
#2
Fernando de Barros, Sergio Setúbal, José Manoel Martinho, Loraine Ferraz, Andressa Gaudêncio
Background: Obesity is an epidemic and chronic disease that can bring other comorbidities to the patient. Non-alcoholic fatty liver disease is present in up to 90% of these patients and can progress to hepatitis and hepatocarcinoma. The relationship of this liver disease and obesity is already well known; however, it is possible that some parameters of the comorbidities are more related than others in the pathophysiology of the disease. Aim: Was analyzed the relationship between non-alcoholic fatty liver disease (NAFLD) and the comorbidities of metabolic syndrome in morbidly obese patients...
November 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/28074608/aged-garlic-extract-suppresses-the-increase-of-plasma-glycated-albumin-level-and-enhances-the-amp-activated-protein-kinase-in-adipose-tissue-in-tsod-mice
#3
Satomi Miki, Ken-Ichi Inokuma, Miyuki Takashima, Mitsuho Nishida, Yoko Sasaki, Mitsuyasu Ushijima, Jun-Ichiro Suzuki, Naoaki Morihara
SCOPE: In this study, we investigated the effect of aged garlic extract (AGE) on the high level of blood glucose in Tsumura Suzuki Obese-Diabetes (TSOD) mice. METHODS AND RESULTS: TSOD mice were fed standard diet with or without 2% AGE for 19 weeks. AGE treatment lowered the blood glucose level and significantly reduced the plasma level of glycated albumin in TSOD mice as compared with those without AGE treatment. In addition, AGE treatment increased the level of phosphorylated AMP-activated protein kinase (AMPK) in the adipose tissue, liver and muscle that played an important role in the maintenance of insulin sensitivity...
January 11, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28067098/glycated-albumin-modifies-platelet-adhesion-and-aggregation-responses
#4
Ioana Soaita, Wei Yin, David A Rubenstein
A diabetic vasculature is detrimental to cardiovascular health through the actions of advanced glycation end products (AGEs) on endothelial cells and platelets. Platelets activated by AGEs agonize endothelial responses promoting cardiovascular disease (CVD) development. While it has been established that AGEs can alter platelet functions, little is known about the specific platelet pathways that AGEs modify. Therefore, we evaluated the effects of AGEs on specific salient platelet pathways related to CVDs and whether the effects that AGEs elicit are dependent on glycation extent...
January 9, 2017: Platelets
https://www.readbyqxmd.com/read/28063765/skin-autofluorescence-renal-insufficiency-and-retinopathy-in-patients-with-type-2-diabetes
#5
Rabia Bentata, Audrey Cougnard-Grégoire, Marie Noëlle Delyfer, Cécile Delcourt, Laurence Blanco, Emilie Pupier, Marie Bénédicte Rougier, Kalina Rajaobelina, Marie Hugo, Jean François Korobelnik, Vincent Rigalleau
OBJECTIVES: Advanced glycation end-products (AGEs) are involved in diabetic retinopathy (DR). Their accumulation in tissues can be analyzed by measuring the skin autofluorescence (sAF). We hypothesized that renal insufficiency, another cause of high sAF, may disturb the relation between sAF and DR. RESEARCH DESIGN AND METHODS: We measured sAF with an AGE-Reader in 444 patients with type 2 diabetes (T2D), and we analyzed their retinal status. The associations of sAF with DR, and interaction with renal insufficiency were estimated by multivariate logistic regression analysis...
October 30, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28053889/antioxidant-antiglycation-and-insulinotrophic-properties-of-coccinia-grandis-l-in%C3%A2-vitro-possible-role-in-prevention-of-diabetic-complications
#6
Packirisamy Meenatchi, Ayyakkanuu Purushothaman, Sivaprakasam Maneemegalai
In an attempt to develop Complementary and Alternative Medicine (CAM) for the treatment of diabetes and related complications, the antidiabetic potential of the mature unripe fruits of Coccinia grandis (CGF) was evaluated. Oxidative stress and glycation plays an important role in manifesting of diabetes and vascular complications. Agents with antioxidant and antiglycation properties may retard these pathological alterations. In this study, the edible plant Coccinia grandis was assessed for in vitro estimation of antioxidant and antiglycation potential and its insulinotrophic properties in RINm5F cells...
January 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28042215/urine-albumin-excretion-as-a-marker-of-acute-glycemic-changes-in-isolated-postprandial-hyperglycemia
#7
Alagilawada S Shilpasree, Vidya S Patil, Vijayetha P Patil, Deepti G Ingleshwar
INTRODUCTION: Postprandial hyperglycemia is a major risk factor for the development of cardiovascular diseases (CVDs), and Most of the times it occurs in patients with normal glycemic control diagnosed by fasting blood glucose (FBG) and glycated hemoglobin levels. Urine albumin excretion (UAE) is an independent predictor of CVD risk. AIM: To estimate UAE in isolated postprandial hyperglycemia (IPPHG) patients and to assess the relationship of UAE with FBG and postprandial blood glucose (PPBG) levels...
January 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28038936/association-of-peripheral-nesfatin-1-with-early-stage-diabetic-nephropathy
#8
Amin Irannejad, Alireza Ghajar, Mohsen Afarideh, Elias Khajeh, Sina Noshad, Sadaf Esteghamati, Khashayar Afshari, Farima Kahe, Morsaleh Ganji, Mohammad Saadat, Manouchehr Nakhjavani, Alireza Esteghamati
BACKGROUND: Nesfatin-1 is a newly found anorectic neuropeptide with potent metabolic regulatory effects that its circulating levels are shown to be elevated in diabetes. We compared serum nesfatin-1 in patients with type 2 diabetes and microalbuminuria (30mg/day≤urinary albumin excretion (UAE) <300mg/day) with their control patients with type 2 diabetes and normoalbuminuria (UAE <30mg/day). PATIENTS AND METHODS: In a cross sectional setting, 44 adult patients with type 2 diabetes and microalbuminuria and 44 control patients with type 2 diabetes and normoalbuminuria were evaluated...
December 13, 2016: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28019072/efficacy-safety-and-albuminuria-reducing-effect-of-gemigliptin-in-korean-type-2-diabetes-patients-with-moderate-to-severe-renal-impairment-a-12-week-double-blind-randomized-study-the-guard-study
#9
Sun A Yoon, Byoung G Han, Sung G Kim, Sang Y Han, Young I Jo, Kyung H Jeong, Kook H Oh, Hyoung C Park, Sun H Park, Shin W Kang, Ki R Na, Sun W Kang, Nam H Kim, Young H Jang, Seong H Shin, Dae R Cha
AIMS: This multicentre, randomized, double-blind study investigated the efficacy and safety of gemigliptin in Korean type 2 diabetes mellitus (T2DM) patients with moderate to severe renal impairment (RI). METHODS: The study comprised a 12-week main part and a 40-week extension. We report the results from the main part. In total, 132 patients were randomized to receive gemigliptin (n = 66) or placebo (n = 66). Changes in glycated haemoglobin (HbA1c; primary endpoint), other glycaemic control parameters (fasting plasma glucose, glycated albumin, and fructosamine), lipid profiles, renal function parameters, and safety profiles were evaluated...
December 25, 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28013188/a-capture-method-based-on-the-vc1-domain-reveals-new-binding-properties-of-the-human-receptor-for-advanced-glycation-end-products-rage
#10
Genny Degani, Alessandra A Altomare, Mara Colzani, Caterina Martino, Angelica Mazzolari, Guenter Fritz, Giulio Vistoli, Laura Popolo, Giancarlo Aldini
The Advanced Glycation and Lipoxidation End products (AGEs and ALEs) are a heterogeneous class of compounds derived from the non-enzymatic glycation or protein adduction by lipoxidation break-down products. The receptor for AGEs (RAGE) is involved in the progression of chronic diseases based on persistent inflammatory state and oxidative stress. RAGE is a pattern recognition receptor (PRR) and the inhibition of the interaction with its ligands or of the ligand accumulation have a potential therapeutic effect...
December 18, 2016: Redox Biology
https://www.readbyqxmd.com/read/28005306/non-enzymatic-glycation-interferes-with-fibronectin-integrin-interactions-in-vascular-smooth-muscle-cells
#11
Srijita Dhar, Zhe Sun, Gerald A Meininger, Michael A Hill
OBJECTIVE: We aimed to investigate whether advanced non-enzymatic glycation of the extracellular matrix (ECM) protein, fibronectin, impacts its normal integrin-mediated interaction with arteriolar vascular smooth muscle cells (VSMC). METHODS: Atomic force microscopy (AFM) was performed on cultured VSMC from rat cremaster arterioles to study native and glycated fibronectin (FN and gFN) interactions with cellular integrins. AFM probes were functionalized with FN or gFN or with native or glycated albumin (gAlb) as controls...
December 22, 2016: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28004067/-advanced-glycated-albumin-induces-macrophage-apoptosis-via-activating-caspase-12-pathway
#12
Jin-Guo Li, Qi Hao, Ying-Xue Liu, Peng Li, Peng Li, Xia-Yan Shao, Hua Tian, Yong-Qi Fang, Shu-Tong Yao
The purpose of the present study was to investigate the effect of advanced glycated albumin (AGE-alb) on the activation of caspase-12, a key molecule in endoplasmic reticulum stress (ERS)-associated apoptotic pathway, and to elucidate the underlying molecular mechanisms of macrophage apoptosis. RAW264.7 macrophages were treated with AGE-alb (2, 4 and 6 g/L), control albumin (C-alb, 4 g/L), tunicamycin (TM, 4 mg/L), or pretreated with 4-phenylbutyric acid (PBA, 5 mmol/L) for 1 h and then treated with AGE-alb (4 g/L)...
December 25, 2016: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/28001159/effect-of-cu-ii-on-in-vitro-glycation-of-human-serum-albumin-by-methylglyoxal-a-lc-ms-based-proteomic-approach
#13
Alejandra Sarahi Ramirez Segovia, Kazimierz Wrobel, Francisco Javier Acevedo Aguilar, Alma Rosa Corrales Escobosa, Katarzyna Wrobel
It has been reported that glycation of human serum albumin (HSA) changes its capability for copper binding whereas the increase of free copper might have an impact on protein glycation - a key process in diabetes progression. In this work, proteomic analysis of non-glycated HSA and HSA glycated with methylglyoxal (MGo) in the absence or in the presence of Cu(ii) (0.1; 1.0; 5.0 mg Cu L(-1)) has been undertaken. Trypsin hydrolysates were subjected to capillary HPLC-ESI-QTOF-MS and MS/MS. Raw data were analyzed using two proteomic platforms: MaxQuant () and ProteinScape (Bruker)...
December 21, 2016: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/27995726/glycemic-control-indicator-levels-at-diagnosis-of-neonatal-diabetes-mellitus-comparison-with-other-types-of-insulin-dependent-diabetes-mellitus
#14
Shigeru Suzuki, Akiko Furuya, Yusuke Tanahashi, Hiroshi Azuma, Yukihiro Bando, Soji Kasayama, Masafumi Koga
BACKGROUND: Neonatal diabetes mellitus (NDM) is a monogenic insulin-dependent diabetes that develops within 6 months of age. The progression of hyperglycemia until diagnosis is unknown. Glycemic control indicators at diagnosis are useful to estimate the extent and duration of hyperglycemia. We recently established that age-adjusted glycated albumin (GA) is a useful indicator of glycemic control, regardless of age. OBJECTIVE: To compare the levels of various glycemic control indicators at diagnosis between NDM and other types of insulin-dependent diabetes mellitus...
December 20, 2016: Pediatric Diabetes
https://www.readbyqxmd.com/read/27979058/effect-of-rosmarinic-acid-and-carnosic-acid-on-ages-formation-in-vitro
#15
Juanying Ou, Junqing Huang, Mingfu Wang, Shiyi Ou
This work aimed to investigate the effect of the two main components of rosemary extracts, namely rosmarinic acid (RA) and carnosic acid (CA), on the formation of advanced glycation end-products (AGEs) in vitro. In the bovine serum albumin (BSA)/glucose model, addition of RA and CA at 400μg/mL inhibited fluorescent AGEs by more than 90%, and carboxymethyl lysine (CML) and carboxyethyl lysine (CEL) by 82.7% and 75.2%, and 71.4% and 64.2%, respectively. Moreover, the addition of RA and CA at 400μg/mL inhibited fluorescent AGEs by more than 90% both in the BSA/glyoxal (GO) and BSA/methylglyoxal (MGO) models, the formation of CML by 64...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27965983/xanthine-oxidase-activity-in-type-2-diabetes-mellitus-patients-with-and-without-diabetic-peripheral-neuropathy
#16
Dijana J Miric, Bojana M Kisic, Snezana Filipovic-Danic, Rade Grbic, Ilija Dragojevic, Marko B Miric, Dragana Puhalo-Sladoje
This study investigated the relationship between serum xanthine oxidase (XOD) activity and the occurrence of diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus (T2DM) patients. Serum XOD activity, ischemia-modified albumin (IMA), uric acid (UA), albumin, glycated hemoglobin (HbA1c), advanced glycation end products (AGE), total free thiols, atherogenic index of plasma (AIP), and body mass index (BMI) were measured in 80 T2DM patients (29 with and 51 without DPN), and 30 nondiabetic control subjects...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27933186/effect-of-type-and-amount-of-dietary-carbohydrate-on-biomarkers-of-glucose-homeostasis-and-c-reactive-protein-in-overweight-or-obese-adults-results-from-the-omnicarb-trial
#17
Stephen P Juraschek, Edgar R Miller, Elizabeth Selvin, Vincent J Carey, Lawrence J Appel, Robert H Christenson, Frank M Sacks
OBJECTIVE: The glycemic index (GI) of dietary carbohydrate is thought to affect glucose homeostasis. Recently, the Effect of Amount and Type of Dietary Carbohydrates on Risk for Cardiovascular Heart Disease and Diabetes Study (OmniCarb) trial reported that a low-GI diet did not improve insulin sensitivity. We conducted this ancillary study of the OmniCarb trial to determine the effects of GI and carbohydrate content on glucose homeostasis and inflammation. RESEARCH DESIGN AND METHODS: OmniCarb was a randomized cross-over feeding study conducted in overweight or obese adults without diabetes (N=163)...
2016: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/27923630/association-of-glycated-albumin-to-hba1c-ratio-with-diabetic-retinopathy-but-not-diabetic-nephropathy-in-patients-with-type-2-diabetes
#18
Yutaka Umayahara, Yohei Fujita, Hirotaka Watanabe, Noriko Kasai, Noritaka Fujiki, Masahiro Hatazaki, Masafumi Koga
OBJECTIVES: The ratio of glycated albumin to HbA1c (GA/HbA1c ratio) is a known indicator that reflects fluctuations in plasma glucose. In this study, the association of the GA/HbA1c ratio to diabetic nephropathy and diabetic retinopathy in patients with type 2 diabetes was investigated. DESIGN AND METHODS: Among patients with type 2 diabetes, 613 patients (364 males and 249 females, aged 63.2±12.5, body mass index (BMI) 25.4±4.8kg/m(2)) were enrolled. Patients with overt proteinuria, reduced renal function, or anemia were excluded...
December 5, 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27914132/associations-between-soluble-receptor-for-advanced-glycation-end-products-srage-and-s100a12-en-rage-with-mortality-in-long-term-hemodialysis-patients
#19
Eul Sik Jung, Wookyung Chung, Ae Jin Kim, Han Ro, Jae Hyun Chang, Hyun Hee Lee, Ji Yong Jung
Hemodialysis (HD) patients experience vascular calcification, ultimately leading to high mortality rates. Previously, we reported associations between soluble receptor for advanced glycation end products (sRAGEs) and extracellular newly identified RAGE-binding protein S100A12 (EN-RAGE) and vascular calcification. Here, we extended our observations, investigating whether these biomarkers may be useful for predicting cardiovascular morbidity and mortality in these subjects. Thus, we evaluated the relationship between sRAGE and S100A12 and mortality in long-term HD patients...
January 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27912129/incidence-of-complications-in-young-onset-diabetes-comparing-type-2-with-type-1-the-young-diab-study
#20
Anandakumar Amutha, Ranjit Mohan Anjana, Ulagamathesan Venkatesan, Harish Ranjani, Ranjit Unnikrishnan, K M Venkat Narayan, Viswanathan Mohan, Mohammed K Ali
BACKGROUND: There is little data on the incidence of diabetes complications in young onset type 1 diabetes (T1DM) and type 2 diabetes (T2DM) in non European populations. METHODS: From a tertiary diabetes centre, Chennai, India, we recruited 108 T1DM (defined by abrupt onset of symptoms or diabetic ketoacidosis, absent insulin reserve requiring insulin treatment) and 90 T2DM participants (defined by absence of ketosis, good beta-cell reserve, and good response to oral agents) who were diagnosed between the ages of 10 and 25years, and without any evidence of diabetes complications at diagnosis...
November 17, 2016: Diabetes Research and Clinical Practice
keyword
keyword
52725
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"