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Glycated albumin

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https://www.readbyqxmd.com/read/28194603/systemic-activation-of-nf-%C3%AE%C2%BAb-driven-luciferase-activity-in-transgenic-mice-fed-advanced-glycation-end-products-modified-albumin
#1
Norbert Nass, Kristina Bayreuther, Andreas Simm
Advanced glycation end products (AGEs) are stable end products of the Maillard reaction and accumulate with progressing ageing and degenerative diseases. Significant amounts of AGE-modified peptides are also consumed with processed food. AGEs bind to specific receptors, especially the receptor of AGEs (RAGE). Activation of RAGE then evokes intracellular signalling, finally resulting in the activation of the NF-κB transcription factor and therefore a proinflammatory state. We here analysed, whether NF-κB is activated in short term upon feeding an AGE-modified protein in-vivo...
February 13, 2017: Glycoconjugate Journal
https://www.readbyqxmd.com/read/28192530/non-enzymatic-glucosylation-induced-neo-epitopes-on-human-serum-albumin-a-concentration-based-study
#2
Km Neelofar, Zarina Arif, Jamal Ahmad, Khursheed Alam
Hyperglycaemia induced non enzymatic glycation is accelerated in diabetic patients and aggressively involved in diabetes progression. Human serum albumin (HSA) is the most abundant protein in blood circulation. In hyperglycaemia, it undergoes fast glycation and results in the impairment of structure. Our previous study has demonstrated structural alterations in Amadori-albumin modified with different glucose concentrations from physiological to pathophysiological range. Here, we focused on immunological characterization of Amadori-albumin...
2017: PloS One
https://www.readbyqxmd.com/read/28179690/association-of-vitamin-d-deficiency-with-poor-glycaemic-control-in-diabetic-patients
#3
Khalida Iqbal, Najmul Islam, Naseema Mehboobali, Ali Asghar, Mohammad Perwaiz Iqbal
OBJECTIVE: An association between serum levels of vitamin D and glycaemic control in type-2 diabetes mellitus (DM) patients has been reported in some of the studies carried out in the West. However, there are no reports on this relationship in Pakistani diabetic patients. The aim of this study was to ascertain whether vitamin D levels have any influence on glycaemic control in Pakistani patients with type-2 DM. METHODS: In a cross-sectional survey, relationship between serum levels of 25-hydroxy vitamin D (25(OH)D) and glycated haemoglobin (HbA1C) was examined in 141 type-2 diabetic patients including 102 males and 39 females; age range 22 to 70 years, visiting the Aga Khan University Hospital during July 2013-April 2014...
December 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28170537/adenosine-deaminase-2-induced-hyperpermeability-in-human-retinal-vascular-endothelial-cells-is-suppressed-by-microrna-146b-3p
#4
Yara A Samra, Heba M Saleh, Khaled A Hussein, Nehal M Elsherbiny, Ahmed S Ibrahim, Khaled Elmasry, Sadanand Fulzele, Mamdouh M El-Shishtawy, Laila A Eissa, Mohamed Al-Shabrawey, Gregory I Liou
Purpose: We recently demonstrated that adenosine deaminase-2 (ADA2) contributes to diabetic retinopathy (DR) via up-regulating the production of inflammatory cytokines in macrophages. Also, microRNA (miR)-146b-3p has the ability to inhibit ADA2. The goal of this study was to investigate the potential role of ADA2 and therapeutic benefit of miR-146b-3p in retinal inflammation and endothelial barrier dysfunction during diabetes. Methods: Adenosine deaminase-2 activity was determined by colorimetric method in diabetic human vitreous...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28167326/association-of-grade-of-non-alcoholic-fatty-liver-disease-and-glycated-albumin-to-glycated-hemoglobin-ratio-in-patients-with-type-2-diabetes-mellitus
#5
Chan-Hee Jung, Bora Lee, Dug-Hyun Choi, Sang-Hee Jung, Bo-Yeon Kim, Chul-Hee Kim, Sung-Koo Kang, Ji-Oh Mok
AIMS: The aim of this study was to investigate the association between the glycated albumin (GA) to glycated hemoglobin (HbA1c) (GA/HbA1c) ratio and grade of non-alcoholic fatty liver disease (NAFLD) on ultrasonography (US) in patients with type 2 diabetes mellitus (T2DM). METHODS: This retrospective, cross-sectional study was performed with data obtained from 186 T2DM patients. Participants were assessed for serum GA/HbA1c ratio and fatty liver using US. NAFLD was defined as ultrasonographically detected fatty liver and was graded as normal, mild, moderate, and severe fatty liver...
December 27, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28163568/prevalence-of-microalbuminuria-and-its-correlates-among-diabetic-patients-attending-diabetic-clinic-at-national-guard-hospital-in-alhasa
#6
Aneesah A AlFehaid
INTRODUCTION: Diabetes mellitus is one of the most common diseases encountered in clinical practice. Diabetic nephropathy is a common consequence of long-standing diabetes mellitus; microalbuminuria (MA) is considered an early stage of diabetic nephropathy. OBJECTIVES: To determine the prevalence of miciroalbuminuria in diabetic patients and factors associated with MA. MATERIALS AND METHODS: This cross-sectional study was conducted in the diabetic clinic of the primary health center of the National Guard Hospital...
January 2017: Journal of Family & Community Medicine
https://www.readbyqxmd.com/read/28163034/serum-glycated-albumin-glycated-hemoglobin-and-arterial-stiffness-in-a-general-chinese-population
#7
Qiang Zeng, Sheng-Yong Dong, Man-Liu Wang, Wei-Min Wang, Jin-Ming Li, Zheng-Xue Dai, Jie Li, Shu-Wen Yang, Ling Zhu
BACKGROUND: Both glycated albumin (GA) and glycated hemoglobin (HbA1c) reflect the mean glucose levels. This study was conducted to investigate the relationships among GA, HbA1c, and arterial stiffness in the general population. METHODS: A total of 11,014 participants were included. Serum GA; HbA1c; and arterial stiffness indices, including brachial-ankle pulse wave velocity (baPWV) and central systolic blood pressure (cSBP), were measured. Single-factor and multivariate regression analyses were performed...
February 2, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28161386/podocyturia-parallels-proximal-tubule-dysfunction-in-type-2-diabetes-mellitus-patients-independently-of-albuminuria-and-renal-function-decline-a-cross-sectional-study
#8
Ligia Petrica, Mihaela Vlad, Adrian Vlad, Gheorghe Gluhovschi, Florica Gadalean, Victor Dumitrascu, Roxana Popescu, Cristina Gluhovschi, Petru Matusz, Silvia Velciov, Flaviu Bob, Sorin Ursoniu, Daliborca Vlad
AIMS: Detection of podocytes in the urine of patients with type 2 diabetes may indicate severe injury to the podocytes. In the course of type 2 diabetes the proximal tubule is involved in urinary albumin processing. We studied the significance of podocyturia in relation with proximal tubule dysfunction in type 2 diabetes. METHODS: A total of 86 patients with type 2 diabetes (34-normoalbuminuria; 30-microalbuminuria; 22-macroalbuminuria) and 28 healthy subjects were enrolled in the study and assessed concerning urinary podocytes, podocyte-associated molecules, and biomarkers of proximal tubule dysfunction...
January 20, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28155619/quantification-of-specific-glycation-sites-in-human-serum-albumin-as-prospective-type-2-diabetes-mellitus-biomarkers
#9
Sandro Spiller, Andrej Frolov, Ralf Hoffmann
Type 2 diabetes mellitus (T2DM) is the most common lifestyle disease affecting all countries. Due to its asymptomatic onset, it is often diagnosed after irreversible vascular complications have been initiated. Therefore, specific markers characteristic for very early disease stages and suitable for early diagnostics are required. Glycation of plasma proteins, such as human serum albumin (HSA), has been often suggested as marker. However, the total glycation degree of HSA does not provide sufficient information about short-term fluctuations of blood glucose concentrations due to the large number of glycation sites...
February 2, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28150470/jakyakgamcho-tang-and-its-major-component-paeonia-lactiflora-exhibit-potent-anti-glycation-properties
#10
Junghyun Kim, Chan-Sik Kim, Young Sook Kim, Ik Soo Lee, Jin Sook Kim
Purpose: Advanced glycation end products (AGEs) have been implicated in the pathogenesis of diabetes and other age-related diseases. AGE inhibitors or breakers, such as aminoguanidine and alagebrium, have been proposed as therapeutic agents for AGE-related disorders. Jakyakgamcho-tang (JGT) is a well-known traditional herbal formula, which consists of the radix of Paeonia lactiflora Pallas (PR) and the radix and rhizome of Glycyrrhiza uralensis Fisch (GR). The purpose of this study was to evaluate the inhibitory and breaking activities of JGT, PR, and GR against AGEs...
December 31, 2016: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/28130827/advanced-glycation-end-products-stimulate-gene-expression-of-fibroblast-growth-factor-23
#11
Ludmilla Bär, Kristin Wächter, Nicole Wege, Alexander Navarrete Santos, Andreas Simm, Michael Föller
SCOPE: Osteoblasts produce fibroblast growth factor 23 (FGF23), a hormone inhibiting renal phosphate reabsorption and the formation of biologically active vitamin D, calcitriol. FGF23-deficient mice age rapidly and develop age-associated diseases at least in part due to massive calcification. Elevated FGF23 serum levels are detected in patients suffering from acute and chronic renal, cardiovascular, inflammatory, and metabolic diseases. Advanced glycation end products (AGEs) are sugar-modified proteins, nucleic acid, and lipids which contribute to these disorders...
January 28, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28126733/glycation-abolishes-the-cardioprotective-effects-of-albumin-during-ex%C3%A2-vivo-ischemia-reperfusion
#12
Rudo F Mapanga, Danzil E Joseph, Marco Saieva, Florence Boyer, Philippe Rondeau, Emmanuel Bourdon, M Faadiel Essop
Hyperglycemia-induced oxidative stress plays a key role in the onset/progression of cardiovascular diseases. For example, it can trigger formation of advanced glycation end (AGE) products with ischemia-reperfusion performed under hyperglycemic conditions. For this study, we hypothesized that albumin modified by glycation loses its unique cardioprotective properties in the setting of ischemia-reperfusion under high glucose conditions. Here, ex vivo rat heart perfusions were performed under simulated normo- and hyperglycemic conditions, that is Krebs-Henseleit buffer containing 11 mmol/L and 33 mmol/L glucose, respectively, ± normal or glycated albumin preparations...
January 2017: Physiological Reports
https://www.readbyqxmd.com/read/28123707/re-evaluation-of-glycated-hemoglobin-and-glycated-albumin-with-continuous-glucose-monitoring-system-as-markers-of-glycemia-in-patients-with-liver-cirrhosis
#13
Hiroshi Isoda, Hirokazu Takahashi, Yuichiro Eguchi, Motoyasu Kojima, Kanako Inoue, Kenichiro Murayama, Yayoi Matsuda, Keizo Anzai
Liver cirrhosis (LC) is frequently accompanied by glucose intolerance. The present study was designed to determine whether glycated hemoglobin A1c (HbA1c) and glycated albumin (GA) were predictive markers of glycemia, as determined by a continuous glucose monitoring system (CGMS), in patients with LC. A total of 30 patients with LC, including 3, 19, 5, 2 and 1 with LC due to hepatitis B virus, hepatitis C virus, non-alcoholic steatohepatitis, alcohol and unknown causes, respectively, were assessed by CGMS. The average, maximum and minimum blood glucose (BG) levels were measured by CGMS, and correlated with HbA1c and GA...
January 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28112327/anti-glycation-and-anti-oxidative-effects-of-a-phenolic-enriched-maple-syrup-extract-and-its-protective-effects-on-normal-human-colon-cells
#14
Weixi Liu, Zhengxi Wei, Hang Ma, Ang Cai, Yongqiang Liu, Jiadong Sun, Nicholas A DaSilva, Shelby L Johnson, Louis J Kirschenbaum, Bongsup P Cho, Joel A Dain, David C Rowley, Zahir A Shaikh, Navindra P Seeram
Oxidative stress and free radical generation accelerate the formation of advanced glycation endproducts (AGEs) which are linked to several chronic diseases. Published data suggest that phenolic-rich plant foods, show promise as natural anti-AGEs agents due to their anti-oxidation capacities. A phenolic-enriched maple syrup extract (MSX) has previously been reported to show anti-inflammatory and neuroprotective effects but its anti-AGE effects remain unknown. Therefore, herein, we investigated the anti-glycation and anti-oxidation effects of MSX using biochemical and biophysical methods...
January 23, 2017: Food & Function
https://www.readbyqxmd.com/read/28109289/plantamajoside-from-plantago-asiatica-modulates-human-umbilical-vein-endothelial-cell-dysfunction-by-glyceraldehyde-induced-ages-via-mapk-nf-%C3%AE%C2%BAb
#15
Won-Rak Son, Mi-Hyun Nam, Chung-Oui Hong, Yoonsook Kim, Kwang-Won Lee
BACKGROUND: Plantago asiatica has been traditionally used for traditional medicine around East Asia. Plantamajoside (PM), which is isolated from this plant, is known for biological properties including anti-inflammation and antioxidant activity. To demonstrate the biological activity of PM against endothelial dysfunction induced by advanced glycation end-products (AGEs), a cellular inflammatory mechanism system was evaluated in human umbilical vein endothelial cells (HUVECs). METHODS: We obtained PM through previous research in our laboratory...
January 21, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28090231/effects-of-ipragliflozin-on-diabetic-nephropathy-and-blood-pressure-in-patients-with-type-2-diabetes-an-open-label-study
#16
Daisuke Ito, Emi Ikuma-Suwa, Kazuyuki Inoue, Kimie Kaneko, Morifumi Yanagisawa, Kouichi Inukai, Mitsuhiko Noda, Akira Shimada
BACKGROUND: Sodium-glucose cotransporter 2 (SGLT2) inhibitors are novel agents used to treat type 2 diabetic patients. We investigated the efficacy of the SGLT2 inhibitor ipragliflozin on diabetic nephropathy in Japanese patients with type 2 diabetes. METHODS: A 50 mg dose of ipragliflozin was administered for 24 weeks to 50 patients with type 2 diabetes who were concomitantly managed with diet and exercise therapy alone or antidiabetic medications other than SGLT2 inhibitors...
February 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28076482/correlation-of-non-alcoholic-fatty-liver-disease-and-features-of-metabolic-syndrome-in-morbidly-obese-patients-in-the-preoperative-assessment-for-bariatric-surgery
#17
Fernando de Barros, Sergio Setúbal, José Manoel Martinho, Loraine Ferraz, Andressa Gaudêncio
Background: Obesity is an epidemic and chronic disease that can bring other comorbidities to the patient. Non-alcoholic fatty liver disease is present in up to 90% of these patients and can progress to hepatitis and hepatocarcinoma. The relationship of this liver disease and obesity is already well known; however, it is possible that some parameters of the comorbidities are more related than others in the pathophysiology of the disease. Aim: Was analyzed the relationship between non-alcoholic fatty liver disease (NAFLD) and the comorbidities of metabolic syndrome in morbidly obese patients...
November 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/28074608/aged-garlic-extract-suppresses-the-increase-of-plasma-glycated-albumin-level-and-enhances-the-amp-activated-protein-kinase-in-adipose-tissue-in-tsod-mice
#18
Satomi Miki, Ken-Ichi Inokuma, Miyuki Takashima, Mitsuho Nishida, Yoko Sasaki, Mitsuyasu Ushijima, Jun-Ichiro Suzuki, Naoaki Morihara
SCOPE: In this study, we investigated the effect of aged garlic extract (AGE) on the high level of blood glucose in Tsumura Suzuki Obese-Diabetes (TSOD) mice. METHODS AND RESULTS: TSOD mice were fed standard diet with or without 2% AGE for 19 weeks. AGE treatment lowered the blood glucose level and significantly reduced the plasma level of glycated albumin in TSOD mice as compared with those without AGE treatment. In addition, AGE treatment increased the level of phosphorylated AMP-activated protein kinase (AMPK) in the adipose tissue, liver and muscle that played an important role in the maintenance of insulin sensitivity...
January 11, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28067098/glycated-albumin-modifies-platelet-adhesion-and-aggregation-responses
#19
Ioana Soaita, Wei Yin, David A Rubenstein
A diabetic vasculature is detrimental to cardiovascular health through the actions of advanced glycation end products (AGEs) on endothelial cells and platelets. Platelets activated by AGEs agonize endothelial responses promoting cardiovascular disease (CVD) development. While it has been established that AGEs can alter platelet functions, little is known about the specific platelet pathways that AGEs modify. Therefore, we evaluated the effects of AGEs on specific salient platelet pathways related to CVDs and whether the effects that AGEs elicit are dependent on glycation extent...
January 9, 2017: Platelets
https://www.readbyqxmd.com/read/28063765/skin-autofluorescence-renal-insufficiency-and-retinopathy-in-patients-with-type-2-diabetes
#20
Rabia Bentata, Audrey Cougnard-Grégoire, Marie Noëlle Delyfer, Cécile Delcourt, Laurence Blanco, Emilie Pupier, Marie Bénédicte Rougier, Kalina Rajaobelina, Marie Hugo, Jean François Korobelnik, Vincent Rigalleau
OBJECTIVES: Advanced glycation end-products (AGEs) are involved in diabetic retinopathy (DR). Their accumulation in tissues can be analyzed by measuring the skin autofluorescence (sAF). We hypothesized that renal insufficiency, another cause of high sAF, may disturb the relation between sAF and DR. RESEARCH DESIGN AND METHODS: We measured sAF with an AGE-Reader in 444 patients with type 2 diabetes (T2D), and we analyzed their retinal status. The associations of sAF with DR, and interaction with renal insufficiency were estimated by multivariate logistic regression analysis...
October 30, 2016: Journal of Diabetes and its Complications
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