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Vitamin d cardiovascular

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https://www.readbyqxmd.com/read/29161689/interactive-effectiveness-of-angiotensin-converting-enzyme-inhibitors-and-angiotensin-receptor-blockers-or-their-combination-on-survival-of-hemodialysis-patients
#1
Ryo Kido, Tadao Akizawa, Masafumi Fukagawa, Yoshihiro Onishi, Takuhiro Yamaguchi, Shunichi Fukuhara
BACKGROUND: Does the use of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers individually or as a combination confer a survival benefit in hemodialysis patients? The answer to this question is yet unclear. METHODS: We performed a case-cohort study using data from the Mineral and Bone Disorder Outcomes Study for Japanese CKD stage 5D patients (MBD-5D), a 3-year multicenter prospective case-cohort study, including 8,229 hemodialysis patients registered from 86 facilities in Japan...
November 21, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/29160835/vitamin-d-and-neurological-diseases-an-endocrine-view
#2
REVIEW
Carolina Di Somma, Elisabetta Scarano, Luigi Barrea, Volha V Zhukouskaya, Silvia Savastano, Chiara Mele, Massimo Scacchi, Gianluca Aimaretti, Annamaria Colao, Paolo Marzullo
Vitamin D system comprises hormone precursors, active metabolites, carriers, enzymes, and receptors involved in genomic and non-genomic effects. In addition to classical bone-related effects, this system has also been shown to activate multiple molecular mediators and elicit many physiological functions. In vitro and in vivo studies have, in fact, increasingly focused on the "non-calcemic" actions of vitamin D, which are associated with the maintenance of glucose homeostasis, cardiovascular morbidity, autoimmunity, inflammation, and cancer...
November 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29160765/antithrombotic-treatment-in-peripheral-artery-disease
#3
Dan-Mircea Olinic, Dan Alexandru Tataru, Calin Homorodean, Mihail Spinu, Maria Olinic
This review treats antithrombotic use for peripheral arterial disease (PAD). In asymptomatic patients, there are no scientific data to support single antiplatelet therapy (SAPT) for primary prophylaxis. In symptomatic PAD, SAPT with aspirin or clopidogrel is indicated. The efficacy of aspirin is controversial. Clopidogrel may be preferred over aspirin. Ticagrelor is not superior to clopidogrel in reducing major adverse cardiovascular events and major adverse limb events, but lowers the risk of ischaemic stroke...
November 21, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/29156926/-oral-feeding-and-nutritional-improvement-in-hospitals-and-residential-care-homes-industry-innovations
#4
Rosa M Ortega, Ana Isabel Jiménez Ortega, José Miguel Perea Sánchez, Esther Cuadrado Soto, Rosa M Martínez García, Ana M López Sobaler
OBJECTIVES: Inpatient and institutionalized elderly patients are population groups vulnerable from the nutritional point of view because oftheir greater risk of deficiencies and because in them the effects of imbalances are more serious than in other groups. Analyzing the possible usefulness of industry innovations offering solutions in the oral feeding of these population groups constitutes the objective of the present work. METHODS: Bibliographic search related to the topic...
October 15, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29155496/insulin-resistance-in-chronic-kidney-disease
#5
REVIEW
Hong Xu, Juan J Carrero
This review provides an overview of insulin resistance (IR) in patients with chronic kidney disease (CKD). IR is a pathological state in which target tissues fail to respond normally to insulin. IR is understood as a consequence of CKD and its prevalence rises particularly in advanced CKD stages. Mechanisms leading to IR are complex and multifactorial, involving post-receptor signaling defects, unhealthy lifestyles, metabolic acidosis, inflammation, oxidative stress, vitamin D deficiency, anemia, and uremic toxicity, as shown by human and experimental studies over the last 30 years...
December 2017: Nephrology
https://www.readbyqxmd.com/read/29155243/the-24-25-to-25-hydroxyvitamin-d-ratio-and-fracture-risk-in-older-adults-the-cardiovascular-health-study
#6
Charles Ginsberg, Ronit Katz, Ian H de Boer, Bryan R Kestenbaum, Michel Chonchol, Michael G Shlipak, Mark J Sarnak, Andrew N Hoofnagle, Dena E Rifkin, Pranav S Garimella, Joachim H Ix
25-hydroxyvitamin D [25(OH)D] may not optimally indicate vitamin D receptor activity. Higher concentrations of its catabolic product 24,25-dihydroxyvitmin D [24,25(OH)2D] and a higher ratio of 24,25(OH)2D to 25(OH)D (the vitamin D metabolite ratio [VMR]) may provide additional information on receptor activity. We compared the strength of associations of these markers with serum PTH concentrations, hip bone mineral density (BMD), and risk of incident hip fracture in community-living older participants in the Cardiovascular Health Study...
November 16, 2017: Bone
https://www.readbyqxmd.com/read/29149839/vitamin-d-parathyroid-hormone-and-metabolic-syndrome-the-pormets-study
#7
Luís Raposo, Sandra Martins, Daniela Ferreira, João Tiago Guimarães, Ana Cristina Santos
BACKGROUND: Vitamin D (VitD) and parathyroid hormone (PTH) play important roles in calcium metabolism and skeletal homeostasis. Estimates of the VitD status in several European countries show large variations between them. In addition, no national population-based estimate has been published. VitD and PTH may also play important roles in cardiovascular risk, which has been suggested to be associated with metabolic syndrome (MetS) and is very prevalent in Portugal. The goal of our study was to evaluate the prevalence of hypovitaminosis D and its determinants as well as PTH serum level determinants and associations of the 25-hydroxyvitamin D and PTH serum levels with MetS and its individual components in a sample of the Portuguese mainland population...
November 17, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29148411/vitamin-d-status-in-spondyloarthritis-results-of-the-asas-comospa-international-study
#8
Sílvia Fernandes, Adrien Etcheto, Désirée van der Heijde, Robert Landewé, Filip van den Bosch, Maxime Dougados, Anna Moltó
OBJECTIVES: Spondyloarthritis (SpA) encompasses both bone production and bone loss, and the latter is particularly linked to inflammation. Vitamin D deficiency has been associated with several inflammatory conditions (i.e. cardiovascular disease, rheumatoid arthritis), but it has been poorly evaluated in SpA patients. We aimed to a) describe the prevalence of vitamin D deficiency in SpA patients worldwide; b) compare SpA patients with and without vitamin D deficiency in terms of disease phenotype, activity severity and comorbidities...
November 16, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29148401/vitamin-d-and-systemic-lupus-erythematous-a-review-of-immunological-and-clinical-aspects
#9
REVIEW
Francesca Dall'Ara, Maurizio Cutolo, Laura Andreoli, Angela Tincani, Sabrina Paolino
OBJECTIVES: To review the relationships between vitamin D status and systemic lupus erythematosus (SLE) concerning immunological, clinical aspects and possible effects of supplementation in disease modulation. METHODS: The literature was reviewed up to January 2017 for studies regarding the epidemiology, pathogenesis, immunological aspects, clinical implications and supplementation strategies. The focus was mainly on studies with implications on every day clinical practice...
November 14, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29138634/the-synergistic-interplay-between-vitamins-d-and-k-for-bone-and-cardiovascular-health-a-narrative-review
#10
REVIEW
Adriana J van Ballegooijen, Stefan Pilz, Andreas Tomaschitz, Martin R Grübler, Nicolas Verheyen
Vitamins D and K are both fat-soluble vitamins and play a central role in calcium metabolism. Vitamin D promotes the production of vitamin K-dependent proteins, which require vitamin K for carboxylation in order to function properly. The purpose of this review is to summarize available evidence of the synergistic interplay between vitamins D and K on bone and cardiovascular health. Animal and human studies suggest that optimal concentrations of both vitamin D and vitamin K are beneficial for bone and cardiovascular health as supported by genetic, molecular, cellular, and human studies...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29137635/the-association-between-serum-25-hydroxyvitamin-d3-concentration-and-serum-lipids-in-the-rural-population-of-china
#11
Huina Ge, Hualei Sun, Teng Wang, Xinxin Liu, Xing Li, Fei Yu, Han Han, Jun Wang, Wenjie Li
BACKGROUND: Vitamin D deficiency is implicated in some diseases, including cardiovascular. Few studies have assessed the correlation between 25-hydroxyvitamin D3 [25(OH) D3] and serum lipids. In this study, we explored the correlation between serum 25(OH) D3 concentrations and serum lipids with a typical sample of the rural population in China. METHODS: Face-to-face research was used to gather some basic information. Fasting serum concentrations of 25-(OH) D3, total cholesterol (TC), triglyceride (TG), HDL cholesterol (HDL-C) and, LDL cholesterol (LDL-C) tested in the laboratory...
November 14, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29135297/-vitamin-d-and-calcium-supplementation-in-elderly-patients-with-hip-fracture
#12
Antal Salamon, Erzsébet Toldy, Csaba Biró, Ákos Mátrai, Tibor Balassa, Zoltán Lőcsei
Vitamin D plays an important role in maintaining calcium and bone metabolism, a risk factor of osteoporosis, fall and fracture in old age. Reduction in D-vitamin levels associated with compensatory increased level of parathyroid hormone causes significant loss of bone matrix, so substitutions of vitamin D and calcium are very important. Many authors publish their recommended doses used for prevention of hip fracture during the last years. Some authors are satisfied only with vitamin D supplementation while others have better experiences with vitamin D and calcium substitution...
October 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29134617/vascular-calcification-is-not-related-to-serum-fetuin-a-and-osteopontin-levels-in-hemodialysis-patients
#13
O Ulutas, M C Taskapan, A Dogan, T Baysal, H Taskapan
INTRODUCTION: Vascular calcification (VC) in hemodialysis (HD) patients is a sign of severe cardiovascular disease and can predict cardiovascular outcomes. Fetuin-A and osteopontin (OPN) inhibit VC. Serum fetuin-A levels are lower in patients with end-stage kidney disease (ESKD) and in those who are on chronic HD therapy. However, there are limited data concerning OPN in patients who are on dialysis. The aim of our study was to determine VC in HD patients, the relationship between VC and 25-OH-vitamin D, fetuin-A, and OPN levels, and independent predictors of VC...
November 13, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29131033/adverse-reactions-to-biologics-in-psoriasis
#14
Stephen J Lockwood, Lisette M Prens, Alexa B Kimball
Psoriasis is a chronic autoimmune disease which affects millions of people worldwide. Not only can psoriasis itself be debilitating and significantly reduce an individual's quality of life, but it is also a risk factor for other systemic disorders, such as metabolic syndrome, cardiovascular disease, and malignancy. Tremendous strides were made in the treatment of psoriasis during the mid-to-late-20th century, including the emergence of topical corticosteroids and vitamin D analogs, methotrexate, systemic retinoids, and phototherapy...
2018: Current Problems in Dermatology
https://www.readbyqxmd.com/read/29126841/-exercise-as-a-protective-cardiovascular-and-metabolic-factor-in-end-stage-renal-disease-patients
#15
Myriam Isnard-Rouchon, Céline Coutard
OBJECTIVE: The aim of the study was to test the effectiveness of Physical Activity (PA) during haemodialysis as a protective treatment against cardiovascular (CV) diseases. METHODS: Eighty volunteer patients were included in this multicentric prospective study and followed for two years: 40 patients in the Exercise group (EX), 40 patients in the Control group (Ctrl). CV risk factors: Total Cholesterol, HDL Cholesterol (HDL-c), LDL cholesterol (LDL-c), Triglycerides (TG) and Hemoglobin (Hb), and Prealbumin, Albumin, Parathormon, 25-OH Vitamin D, were checked at Month 0 (M0) and Month 24 (M24)...
November 7, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29124703/vitamin-d-cardiovascular-disease-and-risk-factors
#16
Tea Skaaby, Betina H Thuesen, Allan Linneberg
Observational studies have suggested a possible protective role of vitamin D on the cardiovascular system. The available evidence does not support either cardiovascular benefits or harms of vitamin D supplementation. This chapter provides an overview and discussion of the current knowledge of vitamin D effects from a cardiovascular health perspective. It focuses on vitamin D in relation to cardiovascular disease, i.e. ischemic heart disease, and stroke; the traditional cardiovascular risk factors hypertension, abnormal blood lipids, obesity; and the emerging risk factors hyperparathyroidism, microalbuminuria, chronic obstructive pulmonary diseases, and non-alcoholic fatty liver disease...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29124700/vitamin-d-metabolism-and-the-implications-for-atherosclerosis
#17
Amanda L Bennett, Carl J Lavie
Vitamin D levels and metabolism may play a role in the pathogenesis and treatment of atherosclerosis and subsequent cardiovascular health. Herein, we discuss both normal and disordered vitamin D metabolism as it pertains to atherosclerosis, and we review major clinical trials regarding vitamin D levels and effects of supplementation. Although there are no official recommendations for vitamin D as it applies to atherosclerosis, it is clear that these two entities are linked. Further study of the complex association between vitamin D and atherosclerosis, as well as the effects of supplementation, are recommended...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29114197/low-levels-of-vitamin-d-an-emerging-risk-for-cardiovascular-diseases-a-review
#18
REVIEW
Farrukh Majeed
Sunlight is regarded among greatest gifts that are presented in abundance to the human beings from the God. Sunlight is also a rich source of Vitamin D (Vit D) that prevents us from numerous ailments such as autoimmune disorders, various types of cancer, and the above all cardiovascular diseases (CVD). Evident from recent research that Vit D deficiency may be the cause for hypertension, cardiac autonomic imbalance, vascular endothelial dysfunction, metabolic syndrome, and even diabetes. Concurrently, many studies present research outcomes that are contradictory to earlier results and also raised a concern not for general public but also among their treating physicians...
November 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/29110385/vitamin-d-and-progression-of-carotid-intima-media-thickness-in-hiv-positive-canadians
#19
H Huff, A T Merchant, E Lonn, E Pullenayegum, F Smaill, M Smieja
OBJECTIVES: Based on a growing body of evidence implicating low vitamin D status in the development of cardiovascular disease (CVD), we hypothesized that in Canadian HIV-positive adults, low 25-hydroxyvitamin D (25(OH)D) concentration would be associated with increased subclinical vascular disease progression. METHODS: We prospectively studied the relationship between baseline 25(OH)D and subsequent progression of carotid intima-media thickness (CIMT) between 2002 and 2011, in the Canadian HIV Vascular Study using stored blood specimens...
November 6, 2017: HIV Medicine
https://www.readbyqxmd.com/read/29108191/-an-interpretation-of-the-aasld-practice-guideline-on-the-diagnosis-and-management-of-nonalcoholic-fatty-liver-disease-in-2017
#20
Y M Nan, N Fu, W C Li, L L Kong, X W Yuan, S Y Zhang, L D Liu, Y Lu, L Y Cui
The American Association for the Study of Liver Diseases (AASLD) updated and published the Practice Guidance for the Diagnosis and Management of Nonalcoholic Fatty Liver Disease (NAFLD) in July 2017, which provides recommendations for the accurate diagnosis, treatment, and effective prevention of NAFLD. Related metabolic diseases should be considered during the initial evaluation of patients suspected of NAFLD. Noninvasive diagnostic techniques including transient elastography, magnetic resonance elastography, and serum biochemical models should be used to evaluate the development and progression of liver fibrosis in patients with NAFLD...
September 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
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