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https://www.readbyqxmd.com/read/28926839/visualization-of-culprit-perforators-in-anterolateral-pontine-infarction-high-resolution-magnetic-resonance-imaging-study
#1
Sang Hun Lee, Seung Chai Jung, Dong Wha Kang, Sun U Kwon, Jong S Kim
BACKGROUND: The stroke mechanism for anterolateral pontine infarction (ALPI) is poorly understood. We aimed to investigate the perforator arteries relevant to ALPI using high-resolution MRI (HR-MRI). METHODS: Of 62 patients with ALPI who were admitted to the Asan Medical Center, 13 patients agreed to participate in this study. We used HR-MRI with a 3-Tesla scanner and assessed the perforating branches directly connected with the infarcted area. RESULTS: Perforating arteries penetrating ALPI were identified in all 13 patients...
September 19, 2017: European Neurology
https://www.readbyqxmd.com/read/28925314/effect-of-methylphenidate-on-visual-responses-in-the-superior-colliculus-in-the-anaesthetised-rat-role-of-cortical-activation
#2
L Hetherington, E J Dommett, A C Turner, T B Riley, J X Haensel, P G Overton
The mechanism of action of psychostimulant drugs in the treatment of Attention Deficit Hyperactivity Disorder is still largely unknown, although recent evidence suggests one possibility is that the drugs affect the superior colliculus (SC). We have previously demonstrated that systemically administered d-amphetamine attenuates/abolishes visual responses to wholefield light flashes in the superficial layers of the SC in anaesthetised rats, and the present study sought to extend this work to methylphenidate (MPH)...
September 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28924482/atypical-presentation-of-central-pontine-myelinolysis-in-hyperglycemia
#3
Swapna Talluri, Raghu Charumathi, Muhammad Khan, Kerri Kissell
Central pontine myelinolysis (CPM) usually occurs with rapid correction of severe chronic hyponatremia. Despite the pronounced fluctuations in serum osmolality, CPM is rarely seen in diabetics. This is a case report of CPM associated with hyperglycemia. A 45-year-old non-smoking and non-alcoholic African American male with past medical history of type 2 diabetes, hypertension, stage V chronic kidney disease and hypothyroidism presented with a two-week history of intermittent episodes of gait imbalance, slurred speech and inappropriate laughter...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28918857/developing-nursing-competence-future-proofing-nurses-for-the-changing-practice-requirements-of-21st-century-healthcare
#4
EDITORIAL
Keith Weeks, Diana Coben, Gerard Lum, David Pontin
No abstract text is available yet for this article.
September 1, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/28916748/%C3%AE-2-adrenoceptor-mediated-inhibition-in-the-central-amygdala-blocks-fear-conditioning
#5
N M Holmes, J W Crane, M Tang, J Fam, R F Westbrook, A J Delaney
The central amygdala is critical for the acquisition and expression of fear memories. This region receives a dense innervation from brainstem noradrenergic cell groups and has a high level of α2-adrenoceptor expression. Using whole-cell electrophysiological recordings from rat brain slices, we characterise the role of pre-synaptic α2-adrenoceptor in modulating discrete inhibitory and excitatory connections within both the lateral and medial division of the central amygdala. The selective α2-adrenoceptor agonist clonidine blocked the excitatory input from the pontine parabrachial neurons onto neurons of the lateral central amygdala...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28894343/pontine-tegmental-cap-dysplasia-accompanied-by-a-duplicated-internal-auditory-canal
#6
Rodolfo Mendes Queiroz, Lara Zupelli Lauar, Luiz Carlos Alves de Souza, Rafael Gouvêa Gomes de Oliveira, Lucas Giansante Abud
No abstract text is available yet for this article.
July 2017: Radiologia Brasileira
https://www.readbyqxmd.com/read/28886046/effects-of-water-avoidance-stress-on-peripheral-and-central-responses-during-bladder-filling-in-the-rat-a-multidisciplinary-approach-to-the-study-of-urologic-chronic-pelvic-pain-syndrome-mapp-research-network-study
#7
Zhuo Wang, Harriet H Chang, Yunliang Gao, Rong Zhang, Yumei Guo, Daniel P Holschneider, Larissa V Rodriguez
Stress plays a role in the exacerbation and possibly the development of functional lower urinary tract disorders. Chronic water avoidance stress (WAS) in rodents is a model with high construct and face validity to bladder hypersensitive syndromes, such as interstitial cystitis/bladder pain syndrome (IC/BPS), characterized by urinary frequency and bladder hyperalgesia and heightened stress responsiveness. Given the overlap of the brain circuits involved in stress, anxiety, and micturition, we evaluated the effects chronic stress has on bladder function, as well as its effects on regional brain activation during bladder filling...
2017: PloS One
https://www.readbyqxmd.com/read/28884116/the-role-of-pontin-and-reptin-in-cellular-physiology-and-cancer-etiology
#8
REVIEW
Yu-Qian Mao, Walid A Houry
Pontin (RUVBL1, TIP49, TIP49a, Rvb1) and Reptin (RUVBL2, TIP48, TIP49b, Rvb2) are highly conserved ATPases of the AAA+ (ATPases Associated with various cellular Activities) superfamily and are involved in various cellular processes that are important for oncogenesis. First identified as being upregulated in hepatocellular carcinoma and colorectal cancer, their overexpression has since been shown in multiple cancer types such as breast, lung, gastric, esophageal, pancreatic, kidney, bladder as well as lymphatic, and leukemic cancers...
2017: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/28881750/new-in-vivo-avatars-of-diffuse-intrinsic-pontine-gliomas-dipg-from-stereotactic-biopsies-performed-at-diagnosis
#9
Alexandre Plessier, Ludivine Le Dret, Pascale Varlet, Kévin Beccaria, Joëlle Lacombe, Sébastien Mériaux, Françoise Geffroy, Laurence Fiette, Patricia Flamant, Fabrice Chrétien, Thomas Blauwblomme, Stéphanie Puget, Jacques Grill, Marie-Anne Debily, David Castel
Diffuse Instrinsic Pontine Glioma is the most aggressive form of High Grade Gliomas in children. The lack of biological material and the absence of relevant models have hampered the development of new therapeutics. Their extensive infiltration of the brainstem renders any surgical resection impossible and until recently biopsies were considered not informative enough and therefore not recommended. Thus, most models were derived from autopsy material. We aimed to develop relevant in vivo DIPG models that mimic this specific disease and its molecular diversity from tumor material obtained at diagnosis...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28871999/multimodal-magnetic-resonance-imaging-of-treatment-induced-changes-to-diffuse-infiltrating-pontine-gliomas-in-children-and-correlation-to-patient-progression-free-survival
#10
Raphael Calmon, Stephanie Puget, Pascale Varlet, Kevin Beccaria, Thomas Blauwblomme, David Grevent, Christian Sainte-Rose, David Castel, Christelle Dufour, Frédéric Dhermain, Stéphanie Bolle, Ana Saitovitch, Monica Zilbovicius, Francis Brunelle, Jacques Grill, Nathalie Boddaert
PURPOSE: To use multimodal magnetic resonance imaging (MRI) to quantify treatment-induced changes in the whole volume of diffuse infiltrating pontine gliomas and correlate them with progression-free survival (PFS). METHODS AND MATERIALS: This prospective study included 22 children aged 3.3 to 14.7 years (median, 5.9 years). Multimodal MRI was performed at 3 distinct time points: before treatment, the first week following radiation therapy (RT), and 2 months after RT...
October 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28871106/3d-imaging-of-the-brain-morphology-and-connectivity-defects-in-a-model-of-psychiatric-disorders-map6-ko-mice
#11
Ulysse Gimenez, Benoit Boulan, Franck Mauconduit, Fanny Taurel, Maxime Leclercq, Eric Denarier, Jacques Brocard, Sylvie Gory-Fauré, Annie Andrieux, Hana Lahrech, Jean Christophe Deloulme
In the central nervous system, microtubule-associated protein 6 (MAP6) is expressed at high levels and is crucial for cognitive abilities. The large spectrum of social and cognitive impairments observed in MAP6-KO mice are reminiscent of the symptoms observed in psychiatric diseases, such as schizophrenia, and respond positively to long-term treatment with antipsychotics. MAP6-KO mice have therefore been proposed to be a useful animal model for these diseases. Here, we explored the brain anatomy in MAP6-KO mice using high spatial resolution 3D MRI, including a volumetric T1w method to image brain structures, and Diffusion Tensor Imaging (DTI) for white matter fiber tractography...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28863115/treatment-of-posterior-inferior-cerebellar-artery-adhesion-on-petrous-bone-during-microvascular-decompression-procedure-for-hemifacial-spasm-technique-note
#12
Xiangyu Wei, Xuesheng Zheng, Shiting Li, Wenxiang Zhong, Zheng Chen
Hemifacial spasm is a hyperactive cranial nerve disease mainly characterized by unilateral facial muscles paroxysmal, involuntary, irregular and clonic convulsion. Standard microvascular decompression is currently the most effective solution. During operation, it is pivotal to conduct a sharp dissection of arachnoid membrane around the caudal cranial nerves and facial, auditory nerves for fully exposure of pontomedullary sulcus, and lateral pontine region. In this article, the authors demonstrate a hemifacial spasm patient who underwent microvascular decompression successfully in their department...
September 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28856152/positron-emission-tomography-imaging-in-diffuse-intrinsic-pontine-glioma
#13
EDITORIAL
Norbert Galldiks, Carina Stegmayr, Antje Willuweit, Karl-Josef Langen
No abstract text is available yet for this article.
August 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28853611/altered-thalamic-connectivity-during-spontaneous-attacks-of-migraine-without-aura-a-resting-state-fmri-study
#14
Faisal Mohammad Amin, Anders Hougaard, Stefano Magon, Till Sprenger, Frauke Wolfram, Egill Rostrup, Messoud Ashina
Background Functional connectivity of brain networks may be altered in migraine without aura patients. Functional magnetic resonance imaging (fMRI) studies have demonstrated changed activity in the thalamus, pons and cerebellum in migraineurs. Here, we investigated the thalamic, pontine and cerebellar network connectivity during spontaneous migraine attacks. Methods Seventeen patients with episodic migraine without aura underwent resting-state fMRI scan during and outside of a spontaneous migraine attack. Primary endpoint was a difference in functional connectivity between the attack and the headache-free days...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28853208/clinical-outcomes-and-toxicity-following-palliative-radiotherapy-for-childhood-cancers
#15
Kimberley S Mak, Stephanie W Lee, Tracy A Balboni, Karen J Marcus
BACKGROUND: Few reports of palliative radiotherapy (RT) for pedialltric malignancies have been published. We described clinical indications, outcomes, and toxicities for children who received palliative RT. PROCEDURE: Pediatric patients (age ≤18 years) treated with palliative RT for incurable cancer from January 1 2008 to February 26, 2014 were included. Diagnosis, details of RT, treatment response, toxicity, and survival were retrospectively reviewed. RESULTS: Forty-six patients received 76 RT courses...
August 29, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28842421/effects-of-selective-deafferentation-on-the-discharge-characteristics-of-medial-rectus-motoneurons
#16
Rosendo G Hernández, Beatriz Benítez-Temiño, Camilo J Morado-Díaz, María América Davis-López de Carrizosa, Rosa R de la Cruz, Angel M Pastor
Medial rectus motoneurons receive two main pontine inputs: abducens internuclear neurons, whose axons course through the medial longitudinal fascicle (MLF), and neurons in the lateral vestibular nucleus, whose axons project through the ascending tract of Deiters (ATD). Abducens internuclear neurons are responsible for conjugate gaze in the horizontal plane, whereas ATD neurons provide medial rectus motoneurons with a vestibular input comprising mainly head velocity.In order to reveal the relative contribution of each input to the oculomotor physiology, single-unit recordings from medial rectus motoneurons were carried out in the control situation and after selective deafferentation from cats with unilateral transection of either the MLF or the ATD...
August 21, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28841124/the-epitrigeminal-approach-to-the-brainstem
#17
Georgios Andrea Zenonos, David Fernandes-Cabral, Maximiliano Nunez, Stefan Lieber, Juan Carlos Fernandez-Miranda, Robert Max Friedlander
OBJECTIVE Surgical approaches to the ventrolateral pons pose a significant challenge. In this report, the authors describe a safe entry zone to the brainstem located just above the trigeminal entry zone which they refer to as the "epitrigeminal entry zone." METHODS The approach is presented in the context of an illustrative case of a cavernous malformation and is compared with the other commonly described approaches to the ventrolateral pons. The anatomical nuances were analyzed in detail with the aid of surgical images and video, anatomical dissections, and high-definition fiber tractography (HDFT)...
August 25, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28840099/specific-dti-seeding-and-diffusivity-analysis-improve-the-quality-and-prognostic-value-of-tms-based-deterministic-dti-of-the-pyramidal-tract
#18
Tizian Rosenstock, Davide Giampiccolo, Heike Schneider, Sophia Jutta Runge, Ina Bährend, Peter Vajkoczy, Thomas Picht
OBJECT: Navigated transcranial magnetic stimulation (nTMS) combined with diffusion tensor imaging (DTI) is used preoperatively in patients with eloquent-located brain lesions and allows analyzing non-invasively the spatial relationship between the tumor and functional areas (e.g. the motor cortex and the corticospinal tract [CST]). In this study, we examined the diffusion parameters FA (fractional anisotropy) and ADC (apparent diffusion coefficient) within the CST in different locations and analyzed their interrater reliability and usefulness for predicting the patients' motor outcome with a precise approach of specific region of interest (ROI) seeding based on the color-coded FA-map...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28829527/does-caffeine-improve-respiratory-rate-during-remifentanil-target-controlled-infusion-sedation-a-case-report-in-endoscopic-sedation
#19
Fabio Sbaraglia, Mariella De Riso, Maria Elena Riccioni, Guido Costamagna, Maria Sammartino
Sedation for endoscopic procedures may be challenging when facing patients with high risk. Traditional techniques, as propofol or meperidine/midazolam administration, cannot ensure an adequate level of safety and efficacy for these patients. Remifentanil infusion is a common alternative, but the incidence of apneic events does not allow achieving safely a good level of analgesia. To overcome with this issue, the authors borrowed suggestions from other medical fields. The clinical practice has recognized a wide utility of methylxanthines (caffeine, theophylline, etc)...
March 2017: Journal of Opioid Management
https://www.readbyqxmd.com/read/28827468/teaching-video-neuroimages-nine-syndrome-in-inferior-paramedian-pontine-infarction-more-than-meets-the-eye
#20
Roderick P P W M Maas, Aad Verrips
No abstract text is available yet for this article.
August 22, 2017: Neurology
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