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https://www.readbyqxmd.com/read/28390438/high-fluoroquinolone-mic-is-associated-with-fluoroquinolone-treatment-failure-in-urinary-tract-infections-caused-by-fluoroquinolone-susceptible-escherichia-coli
#1
Pinyo Rattanaumpawan, Irving Nachamkin, Warren B Bilker, Jason A Roy, Joshua P Metlay, Theoklis E Zaoutis, Ebbing Lautenbach
BACKGROUND: Suboptimal clinical response to fluoroquinolone (FQ) therapy has been clearly documented in patients with Salmonella typhi infection with reduced FQ susceptibility. However, the clinical impact of reduced FQ susceptibility on other infections including E. coli urinary tract infections (UTIs) has never been evaluated. METHODS: We conducted a retrospective cohort study of female patients with fluoroquinolone susceptible E. coli (FQSEC) UTIs who received FQ therapy at outpatient services within University of Pennsylvania Health System, Philadelphia...
April 8, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28350903/advancing-diagnostics-to-address-antibacterial-resistance-the-diagnostics-and-devices-committee-of-the-antibacterial-resistance-leadership-group
#2
Ephraim L Tsalik, Elizabeth Petzold, Barry N Kreiswirth, Robert A Bonomo, Ritu Banerjee, Ebbing Lautenbach, Scott R Evans, Kimberly E Hanson, Jeffrey D Klausner, Robin Patel
Diagnostics are a cornerstone of the practice of infectious diseases. However, various limitations frequently lead to unmet clinical needs. In most other domains, diagnostics focus on narrowly defined questions, provide readily interpretable answers, and use true gold standards for development. In contrast, infectious diseases diagnostics must contend with scores of potential pathogens, dozens of clinical syndromes, emerging pathogens, rapid evolution of existing pathogens and their associated resistance mechanisms, and the absence of gold standards in many situations...
March 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28350902/the-role-of-stewardship-in-addressing-antibacterial-resistance-stewardship-and-infection-control-committee-of-the-antibacterial-resistance-leadership-group
#3
Deverick J Anderson, Timothy C Jenkins, Scott R Evans, Anthony D Harris, Robert A Weinstein, Pranita D Tamma, Jennifer H Han, Ritu Banerjee, Robin Patel, Theoklis Zaoutis, Ebbing Lautenbach
Antibacterial resistance is increasing globally and has been recognized as a major public health threat. Antibacterial stewardship is the coordinated effort to improve the appropriate use of antibiotics with the aim to decrease selective pressure for multidrug-resistant organisms in order to preserve the utility of antibacterial agents. This article describes the activities of the Antibacterial Resistance Leadership Group (ARLG) in the area of antibacterial stewardship. To date, the ARLG has focused intensely on development of rapid diagnostic tests, which (when coupled with educational and institutional initiatives) will enable the robust stewardship that is needed to address the current crisis of antibacterial resistance...
March 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28342769/a-laboratory-study-on-attentional-bias-as-an-underlying-mechanism-affecting-the-link-between-cortisol-and-performance-leading-to-a-discussion-on-the-nature-of-the-stressor-artificial-vs-psychosocial
#4
Franziska Lautenbach
Although cortisol is assumed to influence performance by affecting cognition during stressful and competitive situations, to date this assumption has not been tested empirically. Therefore, the aim of this study was to investigate whether the influence of cortisol on performance is mediated by attentional processing of emotional information. Forty-six male golfers were tested in a mixed design. The cold pressor task (CPT) was used to artificially increase cortisol levels in the experimental group relative to the control group, who had to put their forearm in warm water...
March 23, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28219463/factors-associated-with-persistent-colonisation-with-methicillin-resistant-staphylococcus-aureus
#5
V C Cluzet, J S Gerber, I Nachamkin, S E Coffin, M F Davis, K G Julian, T E Zaoutis, J P Metlay, D R Linkin, P Tolomeo, J A Wise, W B Bilker, B Hu, E Lautenbach
We conducted a prospective cohort study between 1 January 2010 and 31 December 2012 at five adult and paediatric academic medical centres to identify factors associated with persistent methicillin-resistant Staphylococcus aureus (MRSA) colonisation. Adults and children presenting to ambulatory settings with a MRSA skin and soft tissue infection (i.e. index cases), along with household members, performed self-sampling for MRSA colonisation every 2 weeks for 6 months. Clearance of colonisation was defined as two consecutive negative sampling periods...
May 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28159611/age-changes-in-pain-perception-a-systematic-review-and-meta-analysis-of-age-effects-on-pain-and-tolerance-thresholds
#6
REVIEW
Stefan Lautenbacher, Jan H Peters, Michael Heesen, Jennifer Scheel, Miriam Kunz
Demographic changes, with substantial increase in life expectancy, ask for solid knowledge about how pain perception might be altered by aging. Although psychophysical studies on age-related changes in pain perception have been conducted over more than 70 years, meta-analyses are still missing. The present meta-analysis aimed to quantify evidence on age-related changes in pain perception, indexed by pain thresholds and pain tolerance thresholds in young and older healthy adults. After searching PubMed, Google Scholar and PsycINFO using state-of-art screening (PRISMA-criteria), 31 studies on pain threshold and 9 studies assessing pain tolerance threshold were identified...
January 31, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28125956/problems-of-video-based-pain-detection-in-patients-with-dementia-a-road-map-to-an-interdisciplinary-solution
#7
EDITORIAL
Miriam Kunz, Dominik Seuss, Teena Hassan, Jens U Garbas, Michael Siebers, Ute Schmid, Michael Schöberl, Stefan Lautenbacher
BACKGROUND: Given the unreliable self-report in patients with dementia, pain assessment should also rely on the observation of pain behaviors, such as facial expressions. Ideal observers should be well trained and should observe the patient continuously in order to pick up any pain-indicative behavior; which are requisitions beyond realistic possibilities of pain care. Therefore, the need for video-based pain detection systems has been repeatedly voiced. Such systems would allow for constant monitoring of pain behaviors and thereby allow for a timely adjustment of pain management in these fragile patients, who are often undertreated for pain...
January 26, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28123447/erratum-to-allometric-models-and-aboveground-biomass-stocks-of-a-west-african-sudan-savannah-watershed-in-benin
#8
Adéyèmi Chabi, Sven Lautenbach, Vincent Oladokoun Agnila Orekan, Nicholas Kyei-Baffour
[This corrects the article DOI: 10.1186/s13021-016-0058-5.].
December 2016: Carbon Balance and Management
https://www.readbyqxmd.com/read/28034977/which-facial-descriptors-do-care-home-nurses-use-to-infer-whether-a-person-with-dementia-is-in-pain
#9
Stefan Lautenbacher, Elizabeth L Sampson, Sonja Pähl, Miriam Kunz
OBJECTIVES : Pain assessment in people with advanced dementia relies strongly on observable pain behaviors, such as facial expressions, body movement, and vocalizations. However, the process of inferring pain in others based on such observations is not well understood. We aimed to investigate which features of facial expressions caregivers rely on when inferring the presence and intensity of pain in people with dementia. METHODS : A questionnaire, including items on 13 facial descriptors, which were extracted from established observational scales for pain in dementia, was sent to 366 nursing homes in Germany...
December 29, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28013258/epidemiology-of-carbapenem-resistant-klebsiella-pneumoniae-in-a-network-of-long-term-acute-care-hospitals
#10
Jennifer H Han, Ellie J C Goldstein, Jacqueleen Wise, Warren B Bilker, Pam Tolomeo, Ebbing Lautenbach
Background: The rapid emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) represents a major public health threat, including in the long-term acute care hospital (LTACH) setting. Our objective in this study was to describe the epidemiologic characteristics of CRKP in a network of US LTACHs. Methods: An observational study was performed among 64 LTACHs from January 2014 to March 2015. Clinical cultures were included, with the first CRKP isolate recovered from each patient per study quarter evaluated...
April 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27939288/epidemiology-and-characteristics-of-escherichia-coli-sequence-type-131-st131-from-long-term-care-facility-residents-colonized-intestinally-with-fluoroquinolone-resistant-escherichia-coli
#11
Jennifer H Han, Charles Garrigan, Brian Johnston, Irving Nachamkin, Connie Clabots, Warren B Bilker, Evelyn Santana, Pam Tolomeo, Joel Maslow, Janice Myers, Lesley Carson, Ebbing Lautenbach, James R Johnson
The objective of this study was to evaluate molecular and epidemiologic factors associated with Escherichia coli sequence type 131 (ST131) among long-term care facility (LTCF) residents who acquired gastrointestinal tract colonization with fluoroquinolone-resistant E. coli (FQREC). Colonizing isolates from 37 residents who newly developed FQREC colonization at three LTCFs from 2006 to 2008 were evaluated. Twenty-nine (78%) of 37 total FQREC colonizing isolates were ST131. Most ST131 isolates had a distinctive combination of gyrA and parC replacement mutations...
March 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27919774/understanding-facial-expressions-of-pain-in-patients-with-depression
#12
Stefan Lautenbacher, Karl-Juergen Bär, Patricia Eisold, Miriam Kunz
Although depression is associated with more clinical pain complaints, psychophysical data sometimes point to hypoalgesic alterations. Studying the more reflex-like facial expression of pain in patients with depression may offer a new perspective. Facial and psychophysical responses to nonpainful and painful heat stimuli were studied in 23 patients with major depressive disorder (MDD) and 23 matched control participants. As psychophysical data, pain thresholds, tolerance thresholds, and self-report were assessed...
December 2, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27830020/evaluation-of-a-research-use-only-luminex-based-assay-for-measurement-of-procalcitonin-in-serum-samples
#13
Charles Garrigan, Jennifer Han, Pam Tolomeo, Katherine J Johnson, Stephen R Master, Ebbing Lautenbach, Irving Nachamkin
Research use only (RUO) assays do not undergo a validation process similar to test kits used for clinical purposes. Several studies have suggested that RUO assays need to be validated prior to use in any research studies. We evaluated a research use only Luminex platform based assay for measuring serum procalcitonin levels (Bio-Plex Pro(TM) Human Acute Phase Multiplex Assay, Bio-Rad Laboratories, Hercules, CA) for comparability with an FDA cleared assay for procalcitonin (VIDAS B.R.A.H.M.S. PCT Assay, bioMérieux, Durham, NC)...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27825392/impact-of-two-different-antimicrobial-stewardship-methods-on-frequency-of-streamlining-antimicrobial-agents-in-patients-with-bacteremia
#14
Jennifer Lukaszewicz Bushen, Jimish M Mehta, Keith W Hamilton, Shawn Binkley, Daniel R Timko, Ebbing Lautenbach, David A Pegues
OBJECTIVE To assess the likelihood of antimicrobial streamlining between 2 antimicrobial stewardship methods. DESIGN Retrospective cohort study. SETTING Large academic medical center. METHODS Frequency and time to antimicrobial streamlining were compared during a prior authorization and a prospective audit period. Streamlining was defined as an antimicrobial change to a narrower agent if available or to a broader agent if the isolate was resistant to empiric therapy. Patients included were ≥18 years old with monomicrobial bacteremia with S...
November 9, 2016: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/27821207/interrater-reliability-of-surveillance-for-ventilator-associated-events-and-pneumonia
#15
Meeta Prasad Kerlin, William E Trick, Deverick J Anderson, Hilary M Babcock, Ebbing Lautenbach, Renaud Gueret, Michael Klompas
OBJECTIVE To compare interrater reliabilities for ventilator-associated event (VAE) surveillance, traditional ventilator-associated pneumonia (VAP) surveillance, and clinical diagnosis of VAP by intensivists. DESIGN A retrospective study nested within a prospective multicenter quality improvement study. SETTING Intensive care units (ICUs) within 5 hospitals of the Centers for Disease Control and Prevention Epicenters. PATIENTS Patients who underwent mechanical ventilation. METHODS We selected 150 charts for review, including all VAEs and traditionally defined VAPs identified during the primary study and randomly selected charts of patients without VAEs or VAPs...
February 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/27717973/-the-scaphoid-and-rheumatoid-arthritis-classification-by-retrospective-x%C3%A2-ray-analysis
#16
M Lautenbach, A Zach, A Eisenschenk
BACKGROUND: Early destruction of the wrist in rheumatoid arthritis is common and often progressive. Even in times of improved and standardized medical treatment this cannot always be prevented. OBJECTIVES: A limited range of motion, pain, reduced grip-force, and aesthetic deficits of the wrist can impair the daily life of patients. There is an additional risk for destruction of the surrounding soft tissue and adjoining joints of the upper extremity. RESULTS: Destruction of wrist in rheumatoid arthritis is multifactorial and is localized in many different structures of the wrist...
November 2016: Der Orthopäde
https://www.readbyqxmd.com/read/27707354/cognitive-screening-in-multiple-sclerosis-the-five-point-test-as-a-substitute-for-the-pasat-in-measuring-executive-function
#17
Sascha Hansen, Jana Muenssinger, Simona Kronhofmann, Stefan Lautenbacher, Patrick Oschmann, Philipp M Keune
OBJECTIVE: The Paced Auditory Serial Addition Test (PASAT) is frequently employed to measure executive functions in patients with Multiple Sclerosis (MS). In the past, the PASAT has often been criticized because of its stressful and demanding requirements. Continuous utilization might also reduce its validity. The Five-Point Test (FPT) by Regard, Strauss, and Knapp ((1982) Children's production on verbal and non-verbal fluency tasks. Perceptual and Motor Skills, 55, 839-844.) is a short test of figural fluency which might serve as a substitute...
January 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/27701686/-adipositas-new-aspects-in-internistic-care-before-and-after-bariatric-surgery
#18
REVIEW
Clarissa Schulze Zur Wiesch, Anne Lautenbach, Jens Aberle
Indication for bariatric or metabolic surgery depends primarily on body mass index. Recent study results however suggest, that other markers are more reliable predictors of metabolic success. A revision of indication criteria is therefore necessary especially for surgical therapy of type 2 diabetes mellitus. Postoperative management should include screening for postbariatric hypoglycemia and bone density. Furthermore psychologic surveillance is recommended.
September 2016: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27678022/clinical-and-molecular-characterization-of-community-onset-urinary-tract-infections-due-to-extended-spectrum-cephalosporin-resistant-enterobacteriaceae
#19
Judith A Anesi, Ebbing Lautenbach, Irving Nachamkin, Charles Garrigan, Warren B Bilker, Mary Wheeler, Pam Tolomeo, Jennifer H Han
OBJECTIVE To evaluate risk factors for and molecular characteristics of community-onset extended-spectrum cephalosporin-resistant (ESC-R) Enterobacteriaceae (EB) urinary tract infections (UTIs) in a US health system. DESIGN Case-control study. PARTICIPANTS All patients presenting to the emergency department or outpatient practices with EB UTIs from December 21, 2010, through April 22, 2013, were included. Case patients had ESC-R EB UTIs. Control patients had ESC-susceptible EB UTIs and were matched 1:1 on study year...
December 2016: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/27648587/psychological-predictors-of-acute-postoperative-pain-after-hysterectomy-for-benign-causes
#20
Jennifer Scheel, Reinhard Sittl, Norbert Griessinger, Marion Strupf, Andreas Parthum, Violeta Dimova, Claudia Horn-Hofmann, Falk Thiel, Matthias W Beckmann, Stefan Lautenbacher
OBJECTIVES: Psychological parameters have been shown to contribute significantly to the development of acute postoperative pain (APOP). For the prediction of APOP in chest malformation patients and cancer patients, we found pain-specific psychological predictors to be of higher relevance than general psychological predictors. The current study aims to further substantiate these findings. METHODS: In a sample of 73 middle-aged hysterectomy patients, three predictor sets were assessed 1 day before surgery: attentional biases (towards pain-related, social threat, and positive words in a dot-probe task), pain-related emotions and cognitions (pain anxiety, pain catastrophizing, and pain hypervigilance), and affective state variables (depression and somatization)...
September 17, 2016: Clinical Journal of Pain
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