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M Lautenbach, A Zach, A Eisenschenk
BACKGROUND: Early destruction of the wrist in rheumatoid arthritis is common and often progressive. Even in times of improved and standardized medical treatment this cannot always be prevented. OBJECTIVES: A limited range of motion, pain, reduced grip-force, and aesthetic deficits of the wrist can impair the daily life of patients. There is an additional risk for destruction of the surrounding soft tissue and adjoining joints of the upper extremity. RESULTS: Destruction of wrist in rheumatoid arthritis is multifactorial and is localized in many different structures of the wrist...
October 7, 2016: Der Orthopäde
Sascha Hansen, Jana Muenssinger, Simona Kronhofmann, Stefan Lautenbacher, Patrick Oschmann, Philipp M Keune
OBJECTIVE: The Paced Auditory Serial Addition Test (PASAT) is frequently employed to measure executive functions in patients with Multiple Sclerosis (MS). In the past, the PASAT has often been criticized because of its stressful and demanding requirements. Continuous utilization might also reduce its validity. The Five-Point Test (FPT) by Regard, Strauss, and Knapp ((1982) Children's production on verbal and non-verbal fluency tasks. Perceptual and Motor Skills, 55, 839-844.) is a short test of figural fluency which might serve as a substitute...
October 6, 2016: Clinical Neuropsychologist
Clarissa Schulze Zur Wiesch, Anne Lautenbach, Jens Aberle
Indication for bariatric or metabolic surgery depends primarily on body mass index. Recent study results however suggest, that other markers are more reliable predictors of metabolic success. A revision of indication criteria is therefore necessary especially for surgical therapy of type 2 diabetes mellitus. Postoperative management should include screening for postbariatric hypoglycemia and bone density. Furthermore psychologic surveillance is recommended.
September 2016: Deutsche Medizinische Wochenschrift
Judith A Anesi, Ebbing Lautenbach, Irving Nachamkin, Charles Garrigan, Warren B Bilker, Mary Wheeler, Pam Tolomeo, Jennifer H Han
OBJECTIVE To evaluate risk factors for and molecular characteristics of community-onset extended-spectrum cephalosporin-resistant (ESC-R) Enterobacteriaceae (EB) urinary tract infections (UTIs) in a US health system. DESIGN Case-control study. PARTICIPANTS All patients presenting to the emergency department or outpatient practices with EB UTIs from December 21, 2010, through April 22, 2013, were included. Case patients had ESC-R EB UTIs. Control patients had ESC-susceptible EB UTIs and were matched 1:1 on study year...
September 28, 2016: Infection Control and Hospital Epidemiology
Jennifer Scheel, Reinhard Sittl, Norbert Griessinger, Marion Strupf, Andreas Parthum, Violeta Dimova, Claudia Horn-Hofmann, Falk Thiel, Matthias W Beckmann, Stefan Lautenbacher
OBJECTIVES: Psychological parameters have been shown to contribute significantly to the development of acute postoperative pain (APOP). For the prediction of APOP in chest malformation patients and cancer patients, we found pain-specific psychological predictors to be of higher relevance than general psychological predictors. The current study aims to further substantiate these findings. METHODS: In a sample of 73 middle-aged hysterectomy patients, three predictor sets were assessed 1 day before surgery: attentional biases (towards pain-related, social threat, and positive words in a dot-probe task), pain-related emotions and cognitions (pain anxiety, pain catastrophizing, and pain hypervigilance), and affective state variables (depression and somatization)...
September 17, 2016: Clinical Journal of Pain
A Asmus, M Lautenbach, B Schacher, S Kim, A Eisenschenk
BACKGROUND: Operative treatment of the scaphoid nonunion includes avascular corticocancellous and cancellous bone grafts and increasingly the use of vascular pedicled and free vascular corticocancellous grafts. Especially the latter require a fair amount of operative expertise and experience in microsurgical techniques. OBJECTIVE: Which criteria lead to the decision for or against an avascular graft used for reconstruction of scaphoid nonunion? Is our current classification system of a scaphoid pseudarthrosis able to illustrate our diagnostic potential in a way that makes us refer to operative procedures? METHODS: Evaluation of current literature and expert opinions RESULTS: Avascular bone grafts show a high union rate as long as a sufficient vascularisation of the remaining fragments is present...
September 16, 2016: Der Orthopäde
Adéyèmi Chabi, Sven Lautenbach, Vincent Oladokoun Agnila Orekan, Nicholas Kyei-Baffour
BACKGROUND: The estimation of forest biomass changes due to land-use change is of significant importance for estimates of the global carbon budget. The accuracy of biomass density maps depends on the availability of reliable allometric models used in combination with data derived from satellites images and forest inventory data. To reduce the uncertainty in estimates of carbon emissions resulting from deforestation and forest degradation, better information on allometric equations and the spatial distribution of aboveground biomass stocks in each land use/land cover (LULC) class is needed for the different ecological zones...
December 2016: Carbon Balance and Management
Claudia Horn-Hofmann, Janosch A Priebe, Jörg Schaller, Rüdiger Görlitz, Stefan Lautenbacher
In recent years the association of conditioned pain modulation (CPM) with trait fear and anxiety has become a hot topic in pain research due to the assumption that such variables may explain the low CPM efficiency in some individuals. However, empirical evidence concerning this association is still equivocal. Our study is the first to investigate the predictive power of fear and anxiety for CPM by using a well-established psycho-physiological measure of trait fear, i.e. startle potentiation, in addition to two self-report measures of pain-related trait anxiety...
August 26, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Janosch A Priebe, Miriam Kunz, Christian Morcinek, Peter Rieckmann, Stefan Lautenbacher
OBJECTIVE: Nociceptive abnormalities indicating increased pain sensitivity have been reported in patients with Parkinson's disease (PD). The disturbances are mostly responsive to dopaminergic (DA) treatment; yet, there are conflicting results. The objective of the present study was to investigate pain processing and nociception in PD patients in a more comprehensive manner than previous studies. For this purpose, a multi-methods approach was used in order to monitor different levels of the central nervous system (spinal, subcortical-vegetative, cortical)...
September 15, 2016: Journal of the Neurological Sciences
Valerie C Cluzet, Jeffrey S Gerber, Joshua P Metlay, Irving Nachamkin, Theoklis E Zaoutis, Meghan F Davis, Kathleen G Julian, Darren R Linkin, Susan E Coffin, David J Margolis, Judd E Hollander, Warren B Bilker, Xiaoyan Han, Rakesh D Mistry, Laurence J Gavin, Pam Tolomeo, Jacqueleen A Wise, Mary K Wheeler, Baofeng Hu, Neil O Fishman, David Royer, Ebbing Lautenbach
OBJECTIVE To determine the impact of total household decolonization with intranasal mupirocin and chlorhexidine gluconate body wash on recurrent methicillin-resistant Staphylococcus aureus (MRSA) infection among subjects with MRSA skin and soft-tissue infection. DESIGN Three-arm nonmasked randomized controlled trial. SETTING Five academic medical centers in Southeastern Pennsylvania. PARTICIPANTS Adults and children presenting to ambulatory care settings with community-onset MRSA skin and soft-tissue infection (ie, index cases) and their household members...
October 2016: Infection Control and Hospital Epidemiology
Katherine E Goodman, Justin Lessler, Sara E Cosgrove, Anthony D Harris, Ebbing Lautenbach, Jennifer H Han, Aaron M Milstone, Colin J Massey, Pranita D Tamma
BACKGROUND: Timely identification of extended-spectrum β-lactamase (ESBL) bacteremia can improve clinical outcomes while minimizing unnecessary use of broad-spectrum antibiotics, including carbapenems. However, most clinical microbiology laboratories currently require at least 24 additional hours from the time of microbial genus and species identification to confirm ESBL production. Our objective was to develop a user-friendly decision tree to predict which organisms are ESBL producing, to guide appropriate antibiotic therapy...
October 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Stefan Lautenbacher, Miriam Kunz
The analysis of the facial expression of pain promises to be one of the most sensitive tools for the detection of pain in patients with moderate to severe forms of dementia, who can no longer self-report pain. Fine-grain analysis using the Facial Action Coding System (FACS) is possible in research but not feasible for clinical use at the moment because it is too time and effort consuming. Studies using the FACS showed either enhanced facial responses or no alterations of facial activity during pain in patients with cognitive impairment...
June 2, 2016: Current Alzheimer Research
Laura A Lautenbacher, Sunit P Jariwala, Morri E Markowitz, Deepa Rastogi
OBJECTIVE: Asthma-related morbidity is higher among children with vitamin D deficiency and obesity, morbidities that frequently co-exist among minority children. However, the effect of co-existent obesity and vitamin D deficiency on pulmonary function is poorly understood. METHODS: We compared percent-predicted values of pulmonary function across vitamin D categories among 72 obese and 71 normal-weight Hispanic and African-American children with asthma recruited at an urban children's hospital...
June 6, 2016: Pediatric Pulmonology
Kevin J Downes, Scott L Weiss, Jeffrey S Gerber, Sarah B Klieger, Julie C Fitzgerald, Fran Balamuth, Sherri E Kubis, Pam Tolomeo, Warren B Bilker, Xiaoyan Han, Irving Nachamkin, Charles Garrigan, Jennifer H Han, Ebbing Lautenbach, Susan E Coffin
BACKGROUND: Biomarkers that identify critically ill children with systemic inflammatory response syndrome (SIRS) at low risk for bacterial infection may help clinicians reduce unnecessary antibiotic use. METHODS: We conducted a prospective cohort study of children with SIRS and suspected infection admitted to a pediatric intensive care unit from January 5, 2012 to March 7, 2014. We enrolled patients upon initiation of new antibiotics (Time 0) and measured a panel of 8 serum biomarkers daily over 72 hours...
May 4, 2016: Journal of the Pediatric Infectious Diseases Society
Meghan F Davis, Baofeng Hu, Karen C Carroll, Warren B Bilker, Pam Tolomeo, Valerie C Cluzet, Patrick Baron, Jacqueline M Ferguson, Daniel O Morris, Shelley C Rankin, Ebbing Lautenbach, Irving Nachamkin
Two screening methods to detect staphylococcal colonization in humans were compared. Direct plating to CHROMagar (BD Diagnostics) was compared to a broth preenrichment followed by plating to Baird-Parker agar. The broth-enrichment method was comparable to CHROMagar for methicillin-resistant Staphylococcus aureas (MRSA) detection, but the enrichment method was optimum for recovery of coagulase-positive Staphylococcus spp.
July 2016: Journal of Clinical Microbiology
Miriam Kunz, Jürgen Hennig, Anna J Karmann, Stefan Lautenbacher
Although serotonin is known to play an important role in pain processing, the relationship between the polymorphism in 5-HTTLPR and pain processing is not well understood. To examine the relationship more comprehensively, various factors of pain processing having putative associations with 5-HT functioning were studied, namely the subjective pain experience (pain threshold, rating of experimental pain), catastrophizing about pain (Pain Catastrophizing Scale = PCS) and motor responsiveness (facial expression of pain)...
2016: PloS One
Brendan J Kelly, Ebbing Lautenbach, Irving Nachamkin, Susan E Coffin, Jeffrey S Gerber, Barry D Fuchs, Charles Garrigan, Xiaoyan Han, Warren B Bilker, Jacqueleen Wise, Pam Tolomeo, Jennifer H Han
Among surgical intensive care unit (SICU) patients, it is difficult to distinguish bacterial sepsis from other causes of systemic inflammatory response syndrome (SIRS). Biomarkers have proven useful to identify the presence of bacterial infection. We enrolled a prospective cohort of 69 SICU patients with suspected sepsis and assayed the concentrations of 9 biomarkers (α-2 macroglobulin [A2M], C-reactive protein, ferritin, fibrinogen, haptoglobin, procalcitonin [PCT], serum amyloid A, serum amyloid P, and tissue plasminogen activator) at baseline, 24, 48, and 72hours...
May 2016: Diagnostic Microbiology and Infectious Disease
Valerie C Cluzet, Ebbing Lautenbach
No abstract text is available yet for this article.
March 15, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Violeta Dimova, Jörn Lötsch, Kathrin Hühne, Andreas Winterpacht, Michael Heesen, Andreas Parthum, Peter G Weber, Roman Carbon, Norbert Griessinger, Reinhard Sittl, Stefan Lautenbacher
The genetic control of pain has been repeatedly demonstrated in human association studies. In the present study, we assessed the relative contribution of 16 single nucleotide polymorphisms in pain-related genes, such as cathechol-O-methyl transferase gene (COMT), fatty acid amino hydrolase gene (FAAH), transient receptor potential cation channel, subfamily V, member 1 gene (TRPV1), and δ-opioid receptor gene (OPRD1), for postsurgical pain chronification. Ninety preoperatively pain-free male patients were assigned to good or poor outcome groups according to their intensity or disability score assessed at 1 week, 3 months, 6 months, and 1 year after funnel chest correction...
2015: Journal of Pain Research
Sascha Hansen, Jana Muenssinger, Simona Kronhofmann, Stefan Lautenbacher, Patrick Oschmann, Philipp M Keune
BACKGROUND: Cognitive deficits are common in multiple sclerosis (MS) and require continuous monitoring. In routine examinations, screening instruments such as the Brief Repeatable Battery (BRB) may serve this purpose. It was suggested that even a shortened version of the BRB, comprising the Symbol Digit Modalities Test (SDMT), Paced Auditory Serial Addition Test (PASAT) and Selective Reminding Test (SRT), may be feasible. However, an evaluation of sensitivity and specificity of the short BRB in comparison to an independent battery of established tests has not yet occurred...
2015: BMC Neurology
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