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https://www.readbyqxmd.com/read/29768729/adaptive-changes-in-pancreas-post-roux-en-y-gastric-bypass-induced-weight-loss
#1
A Lautenbach, M Wernecke, N Riedel, J Veigel, J Yamamura, S Keller, R Jung, P Busch, O Mann, F K Knop, J J Holst, J J Meier, J Aberle
AIMS: Obesity has been shown to trigger adaptive increases in pancreas parenchymal and fat volume. Consecutively, pancreatic steatosis may lead to beta-cell dysfunction. However, it is not known, whether the pancreatic tissue components decrease with weight loss and pancreatic steatosis is reversible following RYGB. Therefore, the objective of the study was to investigate the effects of RYGB-induced weight loss on pancreatic volume and glucose homeostasis. MATERIALS AND METHODS: 11 patients were recruited in the Obesity Centre of the University Medical Centre Hamburg-Eppendorf...
May 16, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29759437/cleaning-and-sterilization-of-used-cardiac-implantable-electronic-devices-with-process-validation-the-next-hurdle-in-device-recycling
#2
Thomas C Crawford, Craig Allmendinger, Jay Snell, Kevin Weatherwax, Balasundaram Lavan, Timir S Baman, Pat Sovitch, Daniel Alyesh, Thomas Carrigan, Noah Klugman, Denis Kune, Andrew Hughey, Daniel Lautenbach, Nathan Sovitch, Karman Tandon, George Samson, Charles Newman, Sheldon Davis, Archie Brown, Brad Wasserman, Ed Goldman, Sandra L Arlinghaus, Hakan Oral, Kim A Eagle
OBJECTIVES: This study sought to develop a validated, reproducible sterilization protocol, which could be used in the reprocessing of cardiac implantable electronic devices (CIEDs). BACKGROUND: Access to cardiac CIED therapy in high-income and in low- and middle-income countries varies greatly. CIED reuse may reduce this disparity. METHODS: A cleaning and sterilization protocol was developed that includes washing CIEDs in an enzymatic detergent, screw cap and set screw replacement, brushing, inspection, and sterilization in ethylene oxide...
June 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29650340/longitudinal-evaluation-of-efficacy-safety-and-nutritional-status-during-one-year-treatment-with-the-duodenal-jejunal-bypass-liner
#3
Nina Riedel, Katharina Laubner, Anne Lautenbach, Gerhard Schön, Matthias Schlensak, Rainer Stengel, Thomas Eberl, Frank Dederichs, Jens Aberle, Jochen Seufert
BACKGROUND: The endoscopic duodenal-jejunal bypass liner (DJBL) represents a novel temporary endoscopic approach for treatment of obesity-associated type 2 diabetes. Recent results from the German DJBL registry confirmed substantial positive metabolic effects of the DJBL in type 2 diabetes. However, the last Food and Drug Administration trial was stopped due to a high occurrence of hepatic abscesses (3.5%). OBJECTIVES: Here, we analyzed time courses of development of co-morbidities, nutritive changes, and occurrence of adverse events during the 1-year treatment phase with the DJBL in the German DJBL registry...
March 9, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29642850/using-observational-facial-descriptors-to-infer-pain-in-persons-with-and-without-dementia
#4
Stefan Lautenbacher, Anna Lena Walz, Miriam Kunz
BACKGROUND: For patients with advanced dementia, pain diagnosis and assessment requires observations of pain-indicative behavior by others. One type of behavior that has been shown to be a promising candidate is the facial response to pain. To further test how pain-indicative facial responses are, we investigated the predictive power of observational facial descriptors to (i) predict the self-report of pain and (ii) to differentiate between non-painful and painful conditions. In addition, the expertise of the observers (nurses vs...
April 11, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29617738/reply-to-chou-and-trautner
#5
Darunee Chotiprasitakul, Jennifer H Han, Ebbing Lautenbach, Sara E Cosgrove, Anthony D Harris, Pranita D Tamma
No abstract text is available yet for this article.
March 29, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29569313/comparative-efficacy-and-safety-of-the-duodenal-jejunal-bypass-liner-in-obese-patients-with-type-2-diabetes-mellitus-a-case-control-study
#6
Katharina Laubner, Nina Riedel, Katharina Fink, Reinhard W Holl, Reinhard Welp, Hans-Peter Kempe, Anne Lautenbach, Matthias Schlensak, Rainer Stengel, Thomas Eberl, Frank Dederichs, Henning Schwacha, Jochen Seufert, Jens Aberle
AIMS: The duodenal-jejunal bypass liner (DJBL) is an endoscopic device mimicking surgical duodenal-jejunal bypass, and is indicated for the treatment of obesity associated type 2 diabetes mellitus. This analysis was conducted to evaluate efficacy and safety of the DJBL in comparison to lifestyle changes and antidiabetic drugs. MATERIALS AND METHODS: For efficacy and long-term safety of the DJBL, data from 235 obese patients with type 2 diabetes mellitus from the German-DJBL-registry were analyzed...
March 22, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29550934/specificity-of-late-night-salivary-cortisol-measured-by-automated-electrochemiluminescence-immunoassay-for-cushing-s-disease-in-an-obese-population
#7
J Aberle, C Schulze Zur Wiesch, J Flitsch, J Veigel, G Schön, R Jung, F Reining, A Lautenbach, R Rotermund, N Riedel
PURPOSE: Data about the specificity of late-night salivary cortisol (LNSC) in obese subjects are still conflicting. Therefore, with this study, we aimed to evaluate the specificity of LNSC measurement in an obese cohort with or without type 2 diabetes mellitus (T2DM) using an automated electrochemiluminescence immunoassay (ECLIA). METHODS: A total number of 157 patients involving 40 healthy subjects (HS) with BMI < 25 kg/m2 , 83 obese subjects (OS) with BMI ≥ 35 kg/m2 , and 34 histopathologically proven Cushing's disease (CD) were included...
March 17, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29545383/attributable-risk-and-time-course-of-colistin-associated-acute-kidney-injury
#8
Todd A Miano, Ebbing Lautenbach, F Perry Wilson, Wensheng Guo, Yuliya Borovskiy, Sean Hennessy
BACKGROUND AND OBJECTIVES: Despite colistin's longstanding reported association with nephrotoxicity, the attributable risk and timing of toxicity onset are still unknown. Whether substantial toxicity occurs during the initial 72 hours of exposure has important implications for early treatment decisions. The objective of this study was to compare colistin-exposed patients with a matched control group given other broad spectrum antibiotics. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a retrospective cohort study in patients treated for multidrug-resistant Pseudomonas , Klebsiella , or Acinetobacter spp...
April 6, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29531107/digital-rectal-examination-for-prostate-cancer-screening-in-primary-care-a-systematic-review-and-meta-analysis
#9
REVIEW
Leen Naji, Harkanwal Randhawa, Zahra Sohani, Brittany Dennis, Deanna Lautenbach, Owen Kavanagh, Monica Bawor, Laura Banfield, Jason Profetto
PURPOSE: Although the digital rectal examination (DRE) is commonly performed to screen for prostate cancer, there is limited data to support its use in primary care. This review and meta-analysis aims to evaluate the diagnostic accuracy of DRE in screening for prostate cancer in primary care settings. METHODS: We searched MEDLINE, Embase, DARE (Database of Abstracts of Reviews of Effects), Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and CINAHL (Cumulative Index to Nursing and Allied Health Literature) from their inception to June 2016...
March 2018: Annals of Family Medicine
https://www.readbyqxmd.com/read/29522795/associations-of-nocturnal-sleep-with-experimental-pain-and-pain-catastrophizing-in-healthy-volunteers
#10
Anna Julia Karmann, Christoph Lauer, Elisabeth Ziegler, Lena Killian, Claudia Horn-Hofmann, Stefan Lautenbacher
Strong alterations of night sleep (e.g., sleep deprivation, insomnia) have appeared to affect pain in inducing hyperalgesic changes. However, it has remained unclear whether everyday variations of night sleep in healthy individuals have any influence on pain processing. Forty healthy subjects were studied by portable polysomnography (PSG) and sleep questionnaire during two non-consecutive nights at home. Experimental pain parameters (pressure pain threshold, temporal summation = TS, conditioned pain modulation = CPM) and situational pain catastrophizing (Situational Catastrophizing Questionnaire = SCQ) were always assessed the evening before and the morning after sleep recording in a pain laboratory...
March 6, 2018: Biological Psychology
https://www.readbyqxmd.com/read/29504053/trends-in-bmi-glycemic-control-and-obesity-associated-comorbidities-after-explantation-of-the-duodenal-jejunal-bypass-liner-djbl
#11
Nina Riedel, Katharina Laubner, Anne Lautenbach, Gerhard Schön, Matthias Schlensak, Rainer Stengel, Thomas Eberl, Frank Dederichs, Jens Aberle, Jochen Seufert
BACKGROUND: A novel-approach for treatment of obesity and diabetes mellitus type 2 (T2DM) is represented by the endoscopic duodenal-jejunal bypass liner (DJBL). Recent data from the German DJBL registry provide evidence for substantial efficacy of the DJBL during the implantation period in obese patients with T2DM. However, little is known about the trends of glycemic control, BMI, and comorbidities after explantation of the DJBL, which have been investigated in the registry in this report...
March 4, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29450515/gender-and-byline-placement-of-co-first-authors-in-clinical-and-basic-science-journals-with-high-impact-factors
#12
Erin Aakhus, Nandita Mitra, Ebbing Lautenbach, Steven Joffe
No abstract text is available yet for this article.
February 13, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29365075/reply-to-authors
#13
Darunee Chotiprasitakul, Jennifer H Han, Sara E Cosgrove, Anthony D Harris, Ebbing Lautenbach, Pranita D Tamma
No abstract text is available yet for this article.
January 22, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29331850/attentional-biases-in-patients-suffering-from-unipolar-depression-results-of-a-dot-probe-task-investigation
#14
Wolfgang Trapp, Christoph Kalzendorf, Corinna Baum, Göran Hajak, Stefan Lautenbacher
Cognitive models of depression emphasize the relevance of cognitive biases for development, onset and maintenance of major depressive disorder (MDD). Attentional biases consisting of increased attention to negative, mood congruent stimuli and reduced attention to positive, mood-incongruent stimuli are postulated but have rarely been tested for early attentional processing. Furthermore, the role of concurrent depressive mood as a moderating factor has not been studied to date. Participants comprised 30 patients suffering from MDD and 30 healthy control subjects...
March 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29238336/combination-of-classifiers-identifies-fungal-specific-activation-of-lysosome-genes-in-human-monocytes
#15
João P Leonor Fernandes Saraiva, Cristina Zubiria-Barrera, Tilman E Klassert, Maximilian J Lautenbach, Markus Blaess, Ralf A Claus, Hortense Slevogt, Rainer König
Blood stream infections can be caused by several pathogens such as viruses, fungi and bacteria and can cause severe clinical complications including sepsis. Delivery of appropriate and quick treatment is mandatory. However, it requires a rapid identification of the invading pathogen. The current gold standard for pathogen identification relies on blood cultures and these methods require a long time to gain the needed diagnosis. The use of in situ experiments attempts to identify pathogen specific immune responses but these often lead to heterogeneous biomarkers due to the high variability in methods and materials used...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29190320/comparing-the-outcomes-of-adults-with-enterobacteriaceae-bacteremia-receiving-short-course-versus-prolonged-course-antibiotic-therapy-in-a-multicenter-propensity-score-matched-cohort
#16
Darunee Chotiprasitsakul, Jennifer H Han, Sara E Cosgrove, Anthony D Harris, Ebbing Lautenbach, Anna T Conley, Pam Tolomeo, Jacqueleen Wise, Pranita D Tamma
Background: The recommended duration of antibiotic treatment for Enterobacteriaceae bloodstream infections is 7-14 days. We compared the outcomes of patients receiving short-course (6-10 days) vs prolonged-course (11-16 days) antibiotic therapy for Enterobacteriaceae bacteremia. Methods: A retrospective cohort study was conducted at 3 medical centers and included patients with monomicrobial Enterobacteriaceae bacteremia treated with in vitro active therapy in the range of 6-16 days between 2008 and 2014...
January 6, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29117619/development-of-obesity-associated-comorbidities-post-bariatric-surgery-with-a-special-focus-on-diabetes-remission-and-short-term-relapse
#17
Nina Riedel, Anne Lautenbach, Jan Wilhelm Wienecke, Oliver Mann, Jörg Flitsch, Jens Aberle
Purpose The purpose of this study is to study a heterogeneous group of obese patients undergoing Bariatric surgery(BS) and its impact on glycemic control. Secondary endpoints include changes in lipid profile and albuminuria. BS has shown to effectively reduce body-weight. However, the impact on obesity-related comorbidities varies strongly between individuals. Especially postoperative short- and long-term improvement of Diabetes is an active area of investigation. Methods We conducted a retrospective analysis from baseline to 24 months post bariatric surgery in our interdisciplinary obesity outpatient-clinic...
November 8, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29075677/phonetic-characteristics-of-vocalizations-during-pain
#18
Stefan Lautenbacher, Melissa Salinas-Ranneberg, Oliver Niebuhr, Miriam Kunz
INTRODUCTION AND OBJECTIVES: There have, yet, been only few attempts to phonetically characterize the vocalizations of pain, although there is wide agreement that moaning, groaning, or other nonverbal utterance can be indicative of pain. We studied the production of vowels "u," "a," "i", and "schwa" (central vowel, sounding like a darker "e" as in hesitations like "ehm")-as experimental approximations to natural vocalizations...
May 2017: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29037288/global-asthma-burden-and-poverty-in-the-twenty-first-century
#19
Laura Lautenbacher, Matthew S Perzanowski
No abstract text is available yet for this article.
November 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28968345/sleep-and-pain-are-definitely-coupled-but-how-tight-is-this-coupling
#20
Stefan Lautenbacher
No abstract text is available yet for this article.
September 29, 2017: Pain
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