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Non-healing wound

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https://www.readbyqxmd.com/read/28644234/efficacy-of-sodium-hyaluronate-in-murine-diabetic-ocular-surface-diseases
#1
Guohu Di, Xia Qi, Xiaowen Zhao, Songmei Zhang, Qingjun Zhou
PURPOSE: To evaluate the efficacy of sodium hyaluronate (HA) eye drops for the treatment of diabetic ocular surface diseases in mice. METHODS: Male 6- to 8-week-old C57BL/6 mice underwent induction of type 1 diabetes with intraperitoneal injections of streptozotocin, with normal mice as the control. Topical 0.3% HA, 0.1% HA, 0.4% polyethylene glycol eye drops, and normal saline were administered to diabetic mice with an intact or debrided corneal epithelium. Normal saline was applied in the controls...
June 21, 2017: Cornea
https://www.readbyqxmd.com/read/28644107/gingival-perfusion-and-tissue-biomarkers-during-early-healing-of-post-extraction-regenerative-procedures-a-prospective-case-series
#2
Lamees Alssum, Timothy D Eubank, Sashwati Roy, Barbaros S Erdal, Vedat O Yildiz, Dimitris N Tatakis, Binnaz Leblebicioglu
BACKGROUND: Post-extraction alveolar bone loss, mostly affecting the buccal plate, occurs despite regenerative procedures. To better understand possible determinants, this prospective case series assessed gingival blood perfusion and tissue molecular responses in relation to post-extraction regenerative outcomes. METHODS: Adults scheduled to receive bone grafting in maxillary, non-molar, single tooth extraction site were recruited. Clinical documentation included probing pocket depth (PD), keratinized tissue width (KT), tissue biotype (TB), plaque (P) and bleeding...
June 23, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28640728/wound-bed-preparation-a-vital-step-in-the-healing-process
#3
Simon Barrett
Non-healing wounds are a significant burden to healthcare systems, where it is estimated that 4-5% of the adult population has a problem wound at any one time ( Guest et al, 2017 ). It is suggested that infection is the most frequent complication in non-healing wounds where it can prolong patient treatment times and increase resource use ( Gottrup et al, 2013 ). Wound infection develops as a result of an imbalance between the patient's immune system and the conditions in the wound, which subsequently can promote bacterial proliferation ( Wounds UK, 2013 )...
June 22, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28639707/dressings-and-topical-agents-for-treating-pressure-ulcers
#4
REVIEW
Maggie J Westby, Jo C Dumville, Marta O Soares, Nikki Stubbs, Gill Norman
BACKGROUND: Pressure ulcers, also known as bedsores, decubitus ulcers and pressure injuries, are localised areas of injury to the skin or the underlying tissue, or both. Dressings are widely used to treat pressure ulcers and promote healing, and there are many options to choose from including alginate, hydrocolloid and protease-modulating dressings. Topical agents have also been used as alternatives to dressings in order to promote healing.A clear and current overview of all the evidence is required to facilitate decision-making regarding the use of dressings or topical agents for the treatment of pressure ulcers...
June 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28634413/topical-fibronectin-improves-wound-healing-of-irradiated-skin
#5
Maxwell B Johnson, Brandon Pang, Daniel J Gardner, Solmaz Niknam-Benia, Vinaya Soundarajan, Athanasios Bramos, David P Perrault, Kian Banks, Gene K Lee, Regina Y Baker, Gene H Kim, Sunju Lee, Yang Chai, Mei Chen, Wei Li, Lawrence Kwong, Young-Kwon Hong, Alex K Wong
Wound healing is significantly delayed in irradiated skin. To better understand global changes in protein expression after radiation, we utilized a reverse phase protein array (RPPA) to identify significant changes in paired samples of normal and irradiated human skin. Of the 210 proteins studied, fibronectin was the most significantly and consistently downregulated in radiation-damaged skin. Using a murine model, we confirmed that radiation leads to decreased fibronectin expression in the skin as well as delayed wound healing...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28632140/thermal-stability-and-rheological-properties-of-the-non-stick-caf1-biomaterial
#6
Yakup Ulusu, Gema Dura, Helen Waller, Matthew Benning, David Fulton, Jeremy Lakey, Daniel Thomas Peters
The ability to culture cells in three dimensions has many applications, from drug discovery to wound healing. 3D cell culture methods often require appropriate scaffolds that mimic the cellular environments of different tissue types. The choice of material from which these scaffolds are made is of paramount importance, as its properties will define the manner in which cells interact with the scaffold. Caf1 is a protein polymer that is secreted from its host organism, Yersinia pestis, to enable escape from phagocytosis...
June 20, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28631809/anabolic-steroids-for-treating-pressure-ulcers
#7
REVIEW
Cho Naing, Maxine A Whittaker
BACKGROUND: Pressure ulcers, also known as bed sores, pressure sores or decubitus ulcers develop as a result of a localised injury to the skin or underlying tissue, or both. The ulcers usually arise over a bony prominence, and are recognised as a common medical problem affecting people confined to a bed or wheelchair for long periods of time. Anabolic steroids are used as off-label drugs (drugs which are used without regulatory approval) and have been used as adjuvants to usual treatment with dressings, debridement, nutritional supplements, systemic antibiotics and antiseptics, which are considered to be supportive in healing of pressure ulcers...
June 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28624539/polarization-resolved-second-harmonic-microscopy
#8
REVIEW
Nirmal Mazumder, Gitanjal Deka, Wei-Wen Wu, Ankur Gogoi, Guan-Yu Zhuo, Fu-Jen Kao
Second harmonic (SH) microscopy has proven to be a powerful imaging modality over the past years due to its intrinsic advantages as a multiphoton process with endogenous contrast specificity, which allows pinhole-less optical sectioning, non-invasive observation, deep tissue penetration, and the possibility of easier signal detection at visible wavelengths. Depending on the relative orientation between the polarization of the incoming light and the second-order susceptibility of non-centrosymmetric structures, SH microscopy provides the unique capacity to probe the absolute molecular structure of a broad variety of biological tissues without the necessity for additional labeling...
June 14, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28623135/serum-long-non-coding-rna-malat-1-protected-by-exosomes-is-up-regulated-and-promotes-cell-proliferation-and-migration-in-non-small-cell-lung-cancer
#9
Rui Zhang, Yuhong Xia, Zhixin Wang, Jie Zheng, Yafei Chen, Xiaoli Li, Yu Wang, Huaikun Ming
Circulating lncRNAs have been defined as a novel biomarker for non-small cell lung cancer (NSCLC), MALAT-1 was first identified lncRNA that was related to lung cancer metastasis. However, the relationship between exosomal lncRNAs and the diagnosis and prognosis of NSCLC was poorly understood. The aim of this study is to evaluate the clinical significance of serum exosomal MALAT-1 as a biomarker in the metastasis of NSCLC. In this study, we firstly isolated the exosomes from healthy subjects and NSCLC patients...
June 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28622041/the-effects-of-low-level-laser-therapy-on-the-healing-of-bone-defects-in-streptozotocin-induced-diabetic-rats-a-histological-and-morphometric-evaluation
#10
Senem Yildirimturk, Yigit Sirin, Merva Soluk Tekkesin, Gokhan Gurler, Deniz Firat
BACKGROUND: The aim of the present study was to evaluate the effects of LLLT on the healing of bone defects in rats with streptozotocin (STZ) induced DM. METHODS: 28 male Sprague-Dawley rats were used in this study. 14 animals received a single dose of STZ intraperitoneally (65 mg/kg) to induce Type I DM, whereas others were injected only with sterile saline solution. Four weeks later, standard bone defects were created in the tibiae of rats. Surgical wounds in one group from each of the diabetic and non-diabetic animals were irradiated with diode laser for every other day for 4 weeks and they were described as DM+LLLT and CONT+LLLT groups, respectively...
June 16, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28620820/cytoglobin-inhibits-migration-through-pi3k-akt-mtor-pathway-in-fibroblast-cells
#11
Selami Demirci, Ayşegül Doğan, Hüseyin Apdik, Emre Can Tuysuz, Sukru Gulluoglu, Omer Faruk Bayrak, Fikrettin Şahin
Cell proliferation and migration are crucial in many physiological processes including development, cancer, tissue repair, and wound healing. Cell migration is regulated by several signaling molecules. Identification of genes related to cell migration is required to understand molecular mechanism of non-healing chronic wounds which is a major concern in clinics. In the current study, the role of cytoglobin (CYGB) gene in fıbroblast cell migration and proliferation was described. L929 mouse fibroblast cells were transduced with lentiviral particles for CYGB and GFP, and analyzed for cell proliferation and migration ability...
June 15, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28620441/impaired-wound-healing-facts-and-hypotheses-for-multi-professional-considerations-in-predictive-preventive-and-personalised-medicine
#12
REVIEW
Eden Avishai, Kristina Yeghiazaryan, Olga Golubnitschaja
Whereas the physiologic wound healing (WH) successfully proceeds through the clearly defined sequence of the individual phases of wound healing, chronic non-healing wounds/ulcers fail to complete the individual stages and the entire healing process. There are many risk factors both modifiable (such as stress, smoking, inappropriate alcohol consumption, malnutrition, obesity, diabetes, cardio-vascular disease, etc.) and non-modifiable (such as genetic diseases and ageing) strongly contributing to the impaired WH...
March 2017: EPMA Journal
https://www.readbyqxmd.com/read/28620387/notch-regulates-macrophage-mediated-inflammation-in-diabetic-wound-healing
#13
Andrew S Kimball, Amrita D Joshi, Anna E Boniakowski, Matthew Schaller, Jooho Chung, Ronald Allen, Jennifer Bermick, William F Carson, Peter K Henke, Ivan Maillard, Steve L Kunkel, Katherine A Gallagher
Macrophages are essential immune cells necessary for regulated inflammation during wound healing. Recent studies have identified that Notch plays a role in macrophage-mediated inflammation. Thus, we investigated the role of Notch signaling on wound macrophage phenotype and function during normal and diabetic wound healing. We found that Notch receptor and ligand expression are dynamic in wound macrophages during normal healing. Mice with a myeloid-specific Notch signaling defect (DNMAML(floxed)Lyz2(Cre+) ) demonstrated delayed early healing (days 1-3) and wound macrophages had decreased inflammatory gene expression...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28613416/topical-antimicrobial-agents-for-treating-foot-ulcers-in-people-with-diabetes
#14
REVIEW
Jo C Dumville, Benjamin A Lipsky, Christopher Hoey, Mario Cruciani, Marta Fiscon, Jun Xia
BACKGROUND: People with diabetes are at high risk for developing foot ulcers, which often become infected. These wounds, especially when infected, cause substantial morbidity. Wound treatments should aim to alleviate symptoms, promote healing, and avoid adverse outcomes, especially lower extremity amputation. Topical antimicrobial therapy has been used on diabetic foot ulcers, either as a treatment for clinically infected wounds, or to prevent infection in clinically uninfected wounds...
June 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28607463/exploring-a-role-for-regulatory-mirnas-in-wound-healing-during-ageing-involvement-of-mir-200c-in-wound-repair
#15
Eerik Aunin, David Broadley, Mohammed I Ahmed, Andrei N Mardaryev, Natalia V Botchkareva
Multiple factors and conditions can lead to impaired wound healing. Chronic non-healing wounds are a common problem among the elderly. To identify microRNAs negatively impacting the wound repair, global miRNA profiling of wounds collected from young and old mice was performed. A subset of miRNAs that exhibited an age-dependent expression pattern during wound closure was identified, including miR-31 and miR-200c. The expression of miR-200 family members was markedly downregulated upon wounding in both young and aged mice, with an exception of acute upregulation of miR-200c at the early phase of wound healing in aged skin...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28606930/foxn1-transcription-factor-in-epithelial-growth-and-wound-healing
#16
Anna I Grabowska, Tomasz Wilanowski
FOXN1 is a pro-differentiation transcription factor in the skin epithelium. Recently it has also emerged as an important player in controlling skin wound healing process as it actively participates in reepithelialization and is thought to be responsible for the scar formation. FOXN1-positivity is also a feature of pigmented keratinocytes, including nevi, and FOXN1 is an attribute of benign epithelial tumors. Lack of FOXN1 favors skin regeneration process which is displayed by nude mice pointing to FOXN1 as a "switch" between regeneration vs...
June 12, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28599845/evaluating-a-novel-oxygenating-therapeutic-for-its-potential-use-in-the-advancement-of-wound-healing
#17
Jennifer Gueldner, Fan Zhang, Bernd Zechmann, Erica D Bruce
Non-gaseous oxygen therapeutics are emerging technologies in regenerative medicine that aim to sidestep the undesirable effects seen in traditional oxygen therapies, while enhancing tissue and wound regeneration. Using a novel oxygenating therapeutic (Ox66™) several in vitro models including fibroblast and keratinocyte monocultures were evaluated for potential drug toxicity, the ability of cells to recover after chemical injury, and cell migration after scratch assay. It was determined that in both cell lines, there was no significant cytotoxicity found after independent treatment with Ox66™...
June 7, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28598760/the-use-of-modern-dressings-in-managing-split-thickness-skin-graft-donor-sites-a-single-centre-randomised-controlled-trial
#18
M Kazanavičius, A Cepas, V Kolaityte, R Simoliuniene, R Rimdeika
OBJECTIVE: To identify the most appropriate, most suitable and most efficient dressing for split-thickness skin graft (STSG) donor sites. Comparing the wound healing rate, pain severity and duration, as well as the dressing change frequency in four randomised patient groups. METHODS: A single-centre non-blinded randomised controlled trial was carried out during 2010-2014. All patients treated for skin defects/lesions (due to burns, trauma or ulcers) using STSG were included in the study...
June 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28598758/management-of-fournier-s-gangrene-non-healing-wounds-by-autologous-skin-micrograft-biotechnology-a-new-technique
#19
M A Bocchiotti, P Bogetti, A Parisi, F Rivarossa, A Frenello, E A Baglioni
Fournier's gangrene is an acute bacterial infection producing necrosis of the perineum and external genitalia that generally affects elderly men. Although skin grafts and flaps are the standard procedure for reconstruction, sometimes wounds can become chronic. Rigenera Protocol is a new technique based on autologous skin micrografts that reactivates and supports wound healing. A 40-year-old male with Fournier's gangrene, due to a rectal microperforation following diarrhoea, was treated with surgical debridement, negative pressure wound therapy and subsequently coverage with skin grafts...
June 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28598594/tethering-growth-factors-to-collagen-surfaces-using-copper-free-click-chemistry-surface-characterization-and-in-vitro-biological-response
#20
Hyun Jong Lee, Gabriella Fernandes-Cunha, Ilham Putra, Won-Gun Koh, David Myung
Surface modifications with tethered growth factors have mainly been applied to synthetic polymeric biomaterials in well-controlled, acellular settings, followed by seeding with cells. The known bio-orthogonality of copper-free click chemistry provides an opportunity to not only use it in vitro to create scaffolds or pro-migratory tracks in the presence of living cells, but also potentially apply it to living tissues directly as a coupling modality in situ. In this study, we studied the chemical coupling of growth factors to collagen using biocompatible copper-free click chemistry and its effect on the enhancement of growth factor activity in vitro...
June 9, 2017: ACS Applied Materials & Interfaces
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