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https://www.readbyqxmd.com/read/29456724/long-noncoding-rna-blacat1-promotes-cell-proliferation-and-invasion-in-human-cervical-cancer
#1
Dan Shan, Yumin Shang, Tongxiu Hu
Cervical cancer is one of the leading causes of mortality in females worldwide. Predisposition to distant metastasis has reduced the prognosis of this malignancy, thus the identification of a novel agent for metastatic cervical cancer is required. Long noncoding RNAs (LncRNAs) have been reported to serve significant roles in human tumorigenesis. The present study aimed to investigate the effects of a newly discovered LncRNA bladder cancer associated transcript 1 (non-protein coding) (BLACAT1) on cell proliferation and metastasis in cervical cancer...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29456723/mir-96-promotes-breast-cancer-metastasis-by-suppressing-mtss1
#2
Wei Xie, Feng Sun, Lin Chen, Xinjian Cao
Novel, non-invasive biomarkers with high sensitivity and specificity are critical for breast cancer treatment, and prognosis. MicroRNA (miR)-96 has been demonstrated to be highly expressed in several solid malignancies, including breast cancer. However, its expression and function in the metastasis and prognosis of breast cancer have not been fully explored, and its regulation mechanisms remain unclear. In the present study, the serum miR-96 expression in healthy controls, benign and malignant breast cancer types was compared by using reverse transcription-quantitative polymerase chain reaction...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29456686/biochanin-a-extirpates-the-epithelial-mesenchymal-transition-in-a-human-lung-cancer
#3
Yan Wang, Jiao-Jiao Li, Yu-Min Chen
The natural iso-flavonoid, biochanin A, is categorized as a phytoestrogen and has been demonstrated to exhibit various pharmacological properties. However, no effects of biochanin A on lung cancer cell lines have been reported. Therefore, the present study aimed to demonstrate whether biochanin A has the ability to reduce lung cancer triggered pro-inflammatory effects from leukemic monocytes. We studied the release of cytokines, tumor necrosis factor (TNF)-α and interleukin (IL)-6, from the cocultured cells of A427:AML-193...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456396/gingival-tissue-response-following-placement-of-a-light-cure-dressing-and-a-non-eugenol-dressing-after-periodontal-flap-procedure-a-comparative-clinical-study
#4
Ankita Kakar, Arundeep Kaur Lamba, Shruti Tandon, Farrukh Faraz, Abdul Ahad
Aim: The aim was to compare the gingival tissue response following placement of a light cure dressing (Barricaid® ) and a non-eugenol periodontal dressing (Coe-Pak™ ) after periodontal flap procedure. This was carried out by evaluating plaque deposition underneath both the dressings, healing response and the patient preference for each. Materials and Methods: A total of 12 patients with chronic generalized periodontitis requiring surgery in at least two different quadrants were enrolled for this split-mouth study...
January 2018: Journal of Natural Science, Biology, and Medicine
https://www.readbyqxmd.com/read/29455656/the-e3-ubiquitin-ligase-nedd4-mediates-cell-migration-signaling-of-egfr-in-lung-cancer-cells
#5
Genbao Shao, Ranran Wang, Aiqin Sun, Jing Wei, Ke Peng, Qian Dai, Wannian Yang, Qiong Lin
BACKGROUND: EGFR-dependent cell migration plays an important role in lung cancer progression. Our previous study observed that the HECT E3 ubiquitin ligase NEDD4 is significantly correlated with tumor metastasis and required for migration and invasion signaling of EGFR in gastric cancer cells. However, how NEDD4 promotes the EGFR-dependent lung cancer cell migration is unknown. This study is to elucidate the mechanism by which NEDD4 mediates the EGFR lung cancer migration signaling. METHODS: Lentiviral vector-loaded NEDD4 shRNA was used to deplete endogenous NEDD4 in lung cancer cell lines...
February 19, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29455014/cilostazol-improves-wound-healing-in-patients-undergoing-open-bypass-for-ischemic-tissue-loss-a-propensity-score-matching-analysis
#6
Shinsuke Mii, Atsushi Guntani, Eisuke Kawakubo, Kiyoshi Tanaka, Ryoichi Kyuragi
BACKGROUND: Few reports have described the effects of medication on the wound healing of ischemic ulcers after revascularization. This study was conducted to investigate the effects of cilostazol on wound healing in patients who underwent infrainguinal bypass for ischemic tissue loss. METHODS: Two hundred and sixty-three limbs undergoing de novo infrainguinal bypass for tissue loss from January 2004 to December 2015 were divided into two groups based on whether or not cilostazol was administered after surgery...
February 15, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29453888/dual-transcriptomics-reveals-co-evolutionary-mechanisms-of-intestinal-parasite-infections-in-blue-mussels-mytilus-edulis
#7
Marieke E Feis, Uwe John, Ana Lokmer, Pieternella C Luttikhuizen, K Mathias Wegner
On theoretical grounds, antagonistic co-evolution between hosts and their parasites should be a widespread phenomenon but only received little empirical support so far. Consequently, the underlying molecular mechanisms and evolutionary steps remain elusive, especially in non-model systems. Here, we utilised the natural history of invasive parasites to document the molecular underpinnings of co-evolutionary trajectories. We applied a dual-species transcriptomics approach to experimental cross-infections of blue mussel Mytilus edulis hosts and their invasive parasitic copepods Mytilicola intestinalis from two invasion fronts in the Wadden Sea...
February 17, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29453386/anti-fibrotic-effects-of-cxcr4-targeting-i-body-ad-114-in-preclinical-models-of-pulmonary-fibrosis
#8
K Griffiths, D M Habiel, J Jaffar, U Binder, W G Darby, C G Hosking, A Skerra, G P Westall, C M Hogaboam, M Foley
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic lung disease that is prevalent in individuals >50 years of age, with a median survival of 3-5 years and limited therapeutic options. The disease is characterized by collagen deposition and remodeling of the lung parenchyma in a process that is thought to be driven by collagen-expressing immune and structural cells. The G-protein coupled C-X-C chemokine receptor 4, CXCR4, is a candidate therapeutic target for IPF owing to its role in the recruitment of CXCR4 + fibrocytes from the bone marrow to fibrotic lung tissue and its increased expression levels by structural cells in fibrotic lung tissue...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29452285/risk-factors-for-perioperative-morbidity-in-spine-surgeries-of-different-complexities-a-multivariate-analysis-of-1009-consecutive-patients
#9
M Farshad, D E Bauer, C Wechsler, C Gerber, A Aichmair
BACKGROUND CONTEXT: There is a broad spectrum of complications during or after surgical procedures, with differing incidences reported in the published literature. Heterogeneity can be explained by the lack of an established evidence-based classification system for documentation and classification of complications in a standardized manner. PURPOSE: To identify predictive risk factors for peri- and early post-operative morbidities in spine surgeries of different complexities in a large cohort of consecutive patients...
February 13, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29448888/cross-linked-cholecyst-derived-extracellular-matrix-for-abdominal-wall-repair
#10
Jeffrey Chee Yean Chan, Krishna Burugapalli, Yi-Shiang Huang, Jack L Kelly, Abhay Pandit
Abdominal wall repair frequently utilizes either non-degradable or bio-degradable meshes, which are found to stimulate undesirable biological tissue responses or which possess suboptimal degradation rate. In this study, a biologic mesh prototype made from carbodiimide-cross-linked cholecyst-derived extracellular matrix (EDCxCEM) was compared with small intestinal submucosa (Surgisis®), cross-linked bovine pericardium (Peri-Guard®), and polypropylene (Prolene®) meshes in an in vivo rabbit model. The macroscopic appearance and stereological parameters of the meshes were evaluated...
February 16, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29448028/humoral-immune-parameters-in-serum-of-gilthead-seabream-sparus-aurata-l-after-induced-skin-injury
#11
Diana Ceballos-Francisco, Francisco A Guardiola, Héctor Cordero, Alberto Cuesta, M Ángeles Esteban
Skin lesions contribute to significant rates of morbidity and mortality in fish because they permit the entry of pathogens. Different seric immune parameters (IgM level, protease, antiprotease, peroxidase and lysozyme) and bactericidal activity (against Vibrio harveyi and Photobacterium damsealae) of gilthead seabream (Sparus aurata L.) specimens were evaluated after experimentally wounding fish in two body locations (above or below the lateral line). The results demonstrate that the level of several immune parameters present in fish serum (IgM, proteases, peroxidase and bactericidal activity) showed statistically significant variations depending on the site of the skin wound and the time post-wounding (from 0 to 7 days)...
February 12, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29447626/psoriasis-and-wound-healing-outcomes-a-retrospective-cohort-study-examining-wound-complications-and-antibiotic-use
#12
Paulina M Young, Kory K Parsi, Clayton W Schupp, April W Armstrong
Little is known about wound healing in psoriasis. We performed a cohort study examining differences in wound healing complications between patients with and without psoriasis. Psoriasis patients with traumatic wounds were matched 1:3 to non-psoriasis patients with traumatic wounds based on age, gender, and body mass index (BMI). We examined theincidence of wound complications including infection, necrosis, and hematoma as well as incident antibiotic use within three months following diagnosis of a traumatic wound...
November 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29443886/antibacterial-peptides-in-dermatology-strategies-for-evaluation-of-allergic-potential
#13
REVIEW
Milena Deptuła, Anna Wardowska, Maria Dzierżyńska, Sylwia Rodziewicz-Motowidło, Michał Pikuła
During recent decades, the market for peptide-based drugs, including antimicrobial peptides, has vastly extended and evolved. These drugs can be useful in treatment of various types of disorders, e.g., cancer, autoimmune diseases, infections, and non-healing wounds. Although peptides are less immunogenic than other biologic therapeutics, they can still induce immune responses and cause allergies. It is important to evaluate the immunogenic and allergic potential of peptides before they are forwarded to the expensive stages of clinical trials...
February 14, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29443833/experimental-study-on-effects-of-adipose-derived-stem-cell-seeded-silk-fibroin-chitosan-film-on-wound-healing-of-a-diabetic-rat-model
#14
Yan-Yun Wu, Yan-Peng Jiao, Li-Ling Xiao, Min-Min Li, Hong-Wei Liu, Sheng-Hong Li, Xuan Liao, Yong-Tian Chen, Jiang-Xuan Li, Yang Zhang
BACKGROUND: Wound healing is a complex process that relies on growth factors and stimulation of angiogenesis. Tissue engineering materials composed of adipose-derived stem cells (ADSCs) and silk fibroin (SF)/chitosan (CS) may be able to solve this problem. The aim of this study was to investigate the wound-healing potential of ADSC-seeded SF/CS in streptozotocin-induced diabetic rats. MATERIALS AND METHODS: Thirty-six male Sprague-Dawley rats were purchased and randomly assigned into 3 groups: a control group (no graft), a group treated with SF/CS film graft, and a group treated with ADSC-seeded SF/CS graft...
February 13, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29441950/long-noncoding-rna-ccal-promotes-gastric-cancer-cell-proliferation-and-migration-in-a-myc-dependent-way
#15
Yuqiang Shan, Wencheng Kong, Akao Zhu, Panpan Yu, Qi Xie, Sixin Zheng, Huicheng Jin
AIMS: Long non-coding RNAs (lncRNAs) play key roles in cancers, yet their potential molecular mechanisms are not well understood. The objective of this study is to examine the expression, biological functions and mechanism of lncRNA CCAL in gastric cancer (GC). METHODS: MTT and Colony formation assay were used to detect cell proliferation and the colony formation ability of gastric cancer cells. Wound healing, Migration, and invasion assay were respectively used to explore the migration, and invasion in gastric cancer cell lines...
January 2, 2018: Die Pharmazie
https://www.readbyqxmd.com/read/29438925/exploring-determinants-of-care-seeking-behaviour-of-oral-cancer-patients-in-india-a-qualitative-content-analysis
#16
Hemamalini Rath, Swikant Shah, Gaurav Sharma, Ekagrata Mishra
BACKGROUND: A major public health concern in India is the high morbidity and mortality rates of oral cancer because of late diagnosis. Among the several determinants of this late diagnosis, the most important is the healthcare-seeking behaviour of the oral cancer patients. The aim of this study was to explore the care-seeking behaviour and its determinants among oral cancer patients. METHODS: A face-to-face in-depth interview was conducted among 70 oral cancer patients using a semi-structured questionnaire, and qualitative content analysis of the results was performed...
February 10, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29436491/long-non-coding-rna-linc00657-acting-as-mir-590-3p-sponge-to-facilitate-low-concentration-oxidized-low-density-lipoprotein-induced-angiogenesis
#17
Mei-Hua Bao, Guang-Yi Li, Xiao-Shan Huang, Liang Tang, Li-Ping Dong, Jian-Ming Li
Angiogenesis in atherosclerotic plaque promotes plaque growth, causes plaque hemorrhage and violates plaque stability. LINC00657 is a long noncoding RNA highly conserved and abundantly expressed in vascular endothelial cells. The present study was designed to investigate the effects and mechanisms of LINC00675 on the low concentration of oxidized low-density lipoprotein (oxLDL) induced angiogenesis. Cell proliferation assay, transwell assay, wound healing assay, and tube formation assay were conducted to detect the effects of low concentration of oxLDL on angiogenesis; The results discovered that oxLDL promoted the cell proliferation, migration, and tube formation...
February 7, 2018: Molecular Pharmacology
https://www.readbyqxmd.com/read/29435937/laser-capture-microdissection-of-epithelium-from-a%C3%A2-wound-healing-model-for-microrna-analysis
#18
Alyne Simões, Zujian Chen, Yan Zhao, Lin Chen, Virgilia Macias, Luisa A DiPietro, Xiaofeng Zhou
MicroRNAs are ~22 nucleotide-long noncoding RNAs influencing many cellular processes (including wound healing) by their regulatory functions on gene expression. The ability to analyze microRNA in different cells at the wound site is essential for understanding the critical role(s) of microRNA during various phases of wound healing. Laser capture micro-dissection (LCM) is an effective method to distinguish between relevant and non-relevant cells or tissues and enables the researcher to obtain homogeneous, ultra-pure samples from heterogeneous starting material...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29434959/retrospective-observational-cohort-study-on-cosmetic-outcome-of-using-ti-ni-memory-alloy-wire-for-intradermal-suture-following-mastectomy-in-patients-with-breast-cancer
#19
Gang Li, Sida Qin, Xin Sun, Jiansheng Wang, Yunfeng Zhang, Jia Zhang, Jing Zhang, Shou-Ching Tang, Hong Ren
The method of suturing for incisions is crucial for the comprehensive treatment of clinical patients with breast cancer. Suturing is considered a major part of post-surgical recovery and may serve as a marker for evaluation of surgical outcome. The present study aimed to establish an effective means of suturing for patients who received modified radical surgery that helps to improve the cosmetic outcome of the incision. Enrolled patients were divided into an active and a control group. Ti-Ni memory alloy wire for intradermal suture in the active group and silk for interruption suture in the control group were applied to assess the different prognosis-associated factors...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29433670/genistein-induced-anticancer-effects-on-pancreatic-cancer-cell-lines-involves-mitochondrial-apoptosis-g-0-g-1-cell-cycle-arrest-and-regulation-of-stat3-signalling-pathway
#20
Yi-Liang Bi, Min Min, Wei Shen, Yan Liu
BACKGROUND: Genistein is a natural flavonoid that has been reported to exhibit anticancer effects against different types of cancers which include, but are not limited to, breast and oral squamous cell carcinoma. PURPOSE: The present study was designed to evaluate the anticancer effects of the natural flavonoid genistein against pancreatic cancer cell lines and to explore the underlying mechanism. METHODS: Antiproliferative activity was investigated by MTT assay...
January 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
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