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https://www.readbyqxmd.com/read/28445831/carotenoids-in-the-treatment-of-diabetes-mellitus-and-its-complications-a-mechanistic-review
#1
REVIEW
Ali Roohbakhsh, Gholamreza Karimi, Mehrdad Iranshahi
Carotenoids are a large class of natural antioxidants that occur in many vegetables, foods and other natural sources. To date, a large number of biological properties have been reported from carotenoids, particularly protective effects against diabetes mellitus (DM), cancer, and neurodegenerative, metabolic and cardiovascular diseases. However, recent studies including clinical evidences, have shown that carotenoids play a role in the treatment of diabetes via enhancing insulin sensitivity. They are also able to protect the body from long-term consequences of diabetes including infectious diseases, nephropathy, neuronal and eye abnormalities...
April 23, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28445787/adipose-derived-stem-cells-were-impaired-in-restricting-cd4-t-cell-proliferation-and-polarization-in-type-2-diabetic-apoe-mouse
#2
Ming-Hao Liu, Ya Li, Lu Han, Yao-Yuan Zhang, Di Wang, Zhi-Hao Wang, Hui-Min Zhou, Ming Song, Yi-Hui Li, Meng-Xiong Tang, Wei Zhang, Ming Zhong
BACKGROUND: Atherosclerosis (AS) is the most common and serious complication of type 2 diabetes mellitus (T2DM) and is accelerated via chronic systemic inflammation rather than hyperglycemia. Adipose tissue is the major source of systemic inflammation in abnormal metabolic state. Pro-inflammatory CD4(+)T cells play pivotal role in promoting adipose inflammation. Adipose-derived stem cells (ADSCs) for fat regeneration have potent ability of immunosuppression and restricting CD4(+)T cells as well...
April 23, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28444862/role-of-wireless-motility-capsule-in-the-assessment-and-management-of-gastrointestinal-dysmotility-in-patients-with-diabetes-mellitus
#3
C Rouphael, Z Arora, P N Thota, R Lopez, J Santisi, C Funk, M Cline
BACKGROUND: Gastrointestinal (GI) dysmotility is common in diabetic patients. Wireless Motility Capsule (WMC) provides the transit profile of the entire GI tract in a single study. Factors affecting GI dysmotility and utility of WMC study are not clearly established in diabetic patients. Our aims were to study the pattern of GI dysmotility using WMC and evaluate the effect of glycemic control and presence of diabetic microvascular complications on motility impairment in diabetic patients...
April 26, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28444665/genetic-polymorphisms-of-antioxidant-and-antiglycation-enzymes-and-diabetic-complications-how-much-can-we-learn-from-the-genes
#4
Dimitrios Oikonomou, Jan Benedikt Groener, Ruan Cheko, Zoltan Kender, Lars Kihm, Thomas Fleming, Stefan Kopf, Peter P Nawroth
There is growing evidence that reactive metabolites, such as reactive oxygen species and dicarbonyls contribute to diabetic complications. Formation, accumulation, and detoxification of these metabolites are controlled by several enzymes, some of which have genetically determined levels of expression or function. This review not only gives an overview of the different SNPs studied in patients with diabetes mellitus type 1 and type 2, but in addition attempts to bridge the gap between a genetic study and clinical use...
April 25, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28444663/transcriptional-coactivator-p300-and-silent-information-regulator-1-sirt1-gene-polymorphism-associated-with-diabetic-kidney-disease-in-a-chinese-cohort
#5
Kang Tang, Mingfang Sun, Jing Shen, Bo Zhou
One of the most serious complications of diabetes mellitus, which could lead to end-stage renal disease across all demographics, is 'diabetic kidney disease'. However, how diabetic kidney disease develops remains unclear. Studies conducted thus far suggest that a major factor in the origination and development of the disease occurs through histone acetylation modifications. This study aims to examine the probable relationship in Chinese patients suffering from type 2 diabetes. A case-control study was conducted in the Chongqing region of China on the Chinese Han population...
April 25, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28444346/resistant-starch-as-a-novel-dietary-strategy-to-maintain-kidney-health-in-diabetes-mellitus
#6
Gar Yee Koh, Matthew J Rowling
The worldwide prevalence of diabetes mellitus is expected to reach 439 million by 2030. Diabetes increases the risk for developing secondary complications such as nephropathy and cardiovascular disease, critical factors that dictate the survival rate of diabetes patients. Compelling evidence has indicated that the positive impact of fermentable carbohydrates in obesity-related diabetes is mediated by the production of short-chain fatty acids and the modulation of colonic microbiota. This review summarizes the potential implications of dietary resistant starch, a class of fermentable fiber, in glucose homeostasis and kidney health in obesity-associated diabetes and examines the mechanisms underlying the protective effect of resistant starch...
April 22, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28443415/enhancing-diabetes-education-and-self-management-in-south-asian-populations-in-the-uk
#7
Catherine Mutuota, Marie Hill, Anne Claydon
The South Asian population in the UK is at increased risk of developing type 2 diabetes mellitus. This article considers the cultural beliefs that South Asian patients with diabetes may have about their condition, and discusses the challenges that healthcare practitioners may encounter when providing care for this patient group. It offers practical advice on how to enhance the care and treatment of these patients, including the importance of providing culturally sensitive guidance. There may be particular risks and health effects for Muslim patients with diabetes who choose to fast during Ramadan...
April 26, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28442700/the-role-of-the-itln1-gene-rs2274907-polymorphism-in-diabetic-foot-patients
#8
Beata Mrozikiewicz-Rakowska, Agnieszka Sobczyk-Kopcioł, Konrad Szymański, Piotr Nehring, Patryk Szatkowski, Joanna Bartkowiak-Wieczorek, Anna Bogacz, Anna Aniszczuk, Wojciech Drygas, Rafał Płoski, Leszek Czupryniak
INTRODUCTION    Diabetic foot (DF) is a devastating complication of diabetes mellitus (DM) that occurs due to neuropathy and/or atherosclerosis of the lower limbs. Omentin (encoded by the ITLN1 gene) has been implicated as a protective factor in vascular complications of diabetes, likely due to its endothelial vasodilator activity and its anti-inflammatory actions. However, susceptibility to DF in terms of ITLN1 gene polymorphisms has not been studied. OBJECTIVES    This study aimed to evaluate the association between ITLN1 gene polymorphism rs2274907and the occurrence of DF in patients with type 2 diabetes mellitus (T2DM)...
April 25, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28441970/salidroside-contributes-to-reducing-blood-pressure-and-alleviating-cerebrovascular-contractile-activity-in-diabetic-goto-kakizaki-rats-by-inhibition-of-l-type-calcium-channel-in-smooth-muscle-cells
#9
Yu-Guang Ma, Jun-Wei Wang, Yun-Gang Bai, Mei Liu, Man-Jiang Xie, Zhi-Jun Dai
BACKGROUND: Vascular disease is a common and often severe complication in diabetes mellitus. Hyperglycemia and hypertension are considered to be two of the leading risk factors for vascular complications in diabetic patients. However, few pharmacologic agents could provide a combinational therapy for controlling hyperglycemia and blood pressure in diabetic patients at the same time. Salidroside (SAL) is the major active ingredient derived from Rhodiola. Recently, it has been reported that SAL have an obvious hypoglycemic effect in diabetes and show a beneficial activity in diabetic vascular dysfunction...
April 26, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28440522/-nutrition-management-in-obese-patients-with-type-2-diabetes-mellitus-after-laparoscopic-sleeve-gastrectomy
#10
Weihong Tang, Yuhua Chen, Meizhen Pan, Lihua Chen, Lele Zhang, Tingfeng Wang, Xiong Zhang, Peng Zhang, Chengzhu Zheng, Bo Yu
OBJECTIVE: To explore the value of nutrition management in obese patients with type 2 diabetes mellitus(T2DM) after laparoscopic sleeve gastrectomy(LSG). METHODS: Clinical data of 22 obese T2DM patients undergoing LSG from March 2013 to July 2015 in Fudan University Pudong Medical Center were collected. All the patients strictly followed the specialized instruction by nutritionists: diabetic and low calorie diet 3347.2 to 5020.8 kJ (800 to 1200 kcal) per day before the operation; low calorie liquid diet 2510...
April 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28440520/-effect-of-laparoscopic-sleeve-gatrectomy-on-type-2-diabetes-mellitus-in-obese-patients-with-body-mass-index-less-than-40-kg-m-2
#11
Yulin Guo, Xiao Xu, Anjian Wu, Jin Du, Guanglong Dong
OBJECTIVE: To evaluate the effect of laparoscopic sleeve gastrectomy(LSG) on type 2 diabetes mellitus (T2DM) in patient with a body mass index(BMI) less than 40 kg/m(2). METHODS: Twenty four obese patients with T2DM and BMI less than 40 kg/m(2) received LSG between 1 January 2011 and 1 September 2013 at the Department of General Surgery in Chinese PLA General Hospital. The clinical data and 3-year follow-up outcomes regarding weight loss and remission of diabetes were retrospectively analyzed...
April 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28440518/-choice-of-bariatric-and-metabolic-surgical-procedures
#12
Hui Liang, Shibo Lin, Wei Guan
Bariatric and metabolic surgery has become the clinical hot topic of the treatment of metabolic syndromes including obesity and diabetes mellitus, but how to choose the appropriate surgical procedure remains the difficult problem in clinical practice. Clinical guidelines of American Society for Metabolic and Bariatric Surgery(ASMBS)(version 2013) introduced the procedures of bariatric and metabolic surgery mainly including biliopancreatic diversion with duodenal switch(BPD-DS), laparoscopic adjustable gastric banding (LAGB), laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic sleeve gastrectomy(LSG)...
April 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28440515/-interpretation-of-the-international-joint-statement-on-metabolic-surgery-in-the-treatment-algorithm-for-type-2-diabetes
#13
Peng Zhang, Chengzhu Zheng
Along with the soaring prevalence of obesity and type 2 diabetes mellitus (T2DM) globally, metabolic and bariatric surgery (MBS) has been rapidly developing into a major surgical subspecialty. However, the indications, benefits and potential risks of MBS are still controversial so far. In September 2015, the 2nd Diabetes Surgery Summit (DSS-II() was successfully convened, and later on an international joint statement on metabolic surgery in the treatment algorithm for T2DM was released based upon the consensus reached in DSS-II(, aiming to serve as a new global clinical guideline...
April 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28440499/effects-of-tanshinone-iia-on-the-regulation-of-renal-proximal-tubular-fibrosis
#14
Luoyuan Cao, Baoying Huang, Xianguo Fu, Jing Yang, Yinghua Lin, Feng Lin
The development of diabetes mellitus, along with its complications, is a chronic inflammatory response process. Chronic kidney diseases are characterized by renal fibrosis, and fibrosis is an important pathway for end‑stage renal failure. According to previous studies, high glucose (HG) has been demonstrated to be the most important fibrogenesis‑inducing agent. Tanshinone IIA is one of the main components isolated from Danshen (Salvia miltiorrhiza). Although tanshinone IIA has been widely used for the treatment of cardiovascular diseases, the possible role of tanshinone IIA in fibrosis regulation remains to be elucidated and requires investigation...
April 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28440488/dipeptidyl-peptidase%C3%A2-4-inhibitor-sitagliptin-prevents-high-glucose%C3%A2-induced-apoptosis-via-activation-of-amp%C3%A2-activated-protein-kinase-in-endothelial-cells
#15
Chao Wu, Shunying Hu, Nanping Wang, Jianwei Tian
Diabetes mellitus (DM), which is a chronic metabolic disorder, is the primary risk factor of life‑threatening vascular complications. Endothelial apoptosis is important in the development of the initial vascular lesion preceding the diabetic disease. Sitagliptin is a dipeptidyl peptidase‑4 (DPP‑4) inhibitor and extensively used in the clinical treatment of DM. DPP‑4 inhibitors have been demonstrated to be beneficial in the improvement of endothelial homeostasis, however the molecular mechanism by which they exhibit these effects remains to be elucidated...
April 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28440196/mir-126-as-a-therapeutic-agent-for-diabetes-mellitus
#16
Elham Pishavar, Javad Behravan
Diabetes mellitus (DM) is a metabolic disorder which is characterized by inappropriate hyperglycemia. It is becoming an epidemic disease in developing countries. Diabetic patients are frequently afflicted with a vascular dysfunction and wound healing defect. In spite of intense investigations, over the past 2-3 decades, optimal treatment options and related mechanisms are still unclear. MicroRNAs (miRNAs) are small noncoding RNAs considered as regulators of a vast number of biological processes including endothelial cell function controlling molecular signaling pathways in diabetic pathogenesis...
April 24, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28438483/what-role-does-rheumatoid-arthritis-disease-activity-have-in-cardiovascular-risk
#17
Marco Aurelio Ramírez Huaranga, María Dolores Mínguez Sanchez, Miguel Ángel Zarca Diaz de la Espina, Pedro José Espinoza Pardos, Guillermo Romero Aguilera
Rheumatoid arthritis (RA) is associated with a 1.3 to 3-fold increase in mortality, being the major cause of death from cardiovascular complications (40%-50%). Therefore, the initial approach should include cardiovascular risk (CVR) assessment using algorithms adapted for this population. Although, SCOREM is an important advance, there are data indicating that subclinical atherosclerosis may be underdiagnosed. OBJECTIVE: To estimate the strength of association between carotid ultrasound and SCOREM in this population, as well as the implication of disease activity...
April 21, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28438429/association-of-serum-magnesium-level-with-poor-glycemic-control-and-renal-functions-in-nepalese-patients-with-type-2-diabetes-mellitus
#18
Daya Ram Pokharel, Dipendra Khadka, Manoj Sigdel, Naval Kishor Yadav, Ramchandra Kafle, Ravindra Mohan Sapkota, Sanjay Kumar Jha
BACKGROUND: Hypomagnesaemia has been shown to be associated with type 2 diabetes mellitus (T2DM) and its complications. The present study investigated the association of hypomagnesaemia with T2DM and its complications in patients hailed mostly from the western hilly region of Nepal. METHODS: This study was conducted among 150 type 2 diabetic patients and 150 of non-diabetic controls between May to September 2016. Relevant demographic, anthropometric, physiological and biochemical variables were measured using standard protocols...
April 6, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28436760/diabetes-management-by-probiotics-current-knowledge-and-future-pespective
#19
Aziz Homayouni-Rad, Ahmad-Reza Soroush, Leila Khalili, Leila Norouzi-Panahi, Zahra Kasaie, Hanieh-Sadat Ejtahed
Diabetes mellitus, a multifactorial disorder, is related to the intestinal microbiota via numerous molecular mechanisms. The vast increase in the prevalence of diabetes and its associated complications requires a natural and safe solution. There is a growing evidence of gut microbiota effi ciency in improving insulin resistance, impaired insulin secretion, and metabolic complications in diabetic patients. Probiotics are defi ned as live microorganisms that, when ingested in adequate amounts, exert health benefi ts to the host...
April 24, 2017: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
https://www.readbyqxmd.com/read/28436175/chronic-hypertension-and-adverse-pregnancy-outcomes-a-cohort-study
#20
Anca M Panaitescu, Argyro Syngelaki, Natalia Prodan, Ranjit Akolekar, Kypros H Nicolaides
OBJECTIVE: To examine the association between chronic hypertension (CH) and a wide range of adverse pregnancy outcomes after adjustment for confounding factors in obstetric history and maternal characteristics. METHODS: This was a prospective screening study for adverse pregnancy outcomes in women with singleton pregnancies attending the first routine hospital visit at 11(+0) -13(+6) weeks' gestation. Data on maternal characteristics, medical and obstetric history and pregnancy outcomes were collected...
April 23, 2017: Ultrasound in Obstetrics & Gynecology
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