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Diabetes mellitus complication

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https://www.readbyqxmd.com/read/29470354/poor-survival-after-retransplantation-in-nash-cirrhosis
#1
Avesh J Thuluvath, Po-Hung Chen, Paul J Thuluvath, Sergey Kantsevoy, Yulia Savva
BACKGROUND: Nonalcoholic steatohepatitis (NASH) cirrhosis is a common indication for liver transplantation (LT) in the U.S. There is a paucity of data on retransplantation (re-LT) in those who were initially transplanted for NASH. METHODS: We queried the UNOS data sets from 2002-2016 to analyze the outcomes of adults with NASH (n=128) and compared them to groups that received re-LT for cryptogenic cirrhosis (CC, n=189), alcoholic cirrhosis (AC, n=300) or autoimmune hepatitis cirrhosis (AIH-C, n=118) after excluding multiple-organ re-LT and individuals with HCC...
February 20, 2018: Transplantation
https://www.readbyqxmd.com/read/29470134/the-effect-of-aronia-berry-on-type-1-diabetes-in-vivo-and-in-vitro
#2
Yong-Deok Jeon, Sa-Haeng Kang, Kwang-Hyun Moon, Jeong-Ho Lee, Dae-Geun Kim, Wook Kim, Jong-Sung Kim, Byung-Yong Ahn, Jong-Sik Jin
The number of diabetic patients worldwide is increasing, and complications such as stroke and cardiovascular disease are becoming a serious cause of death. Diabetes mellitus is classified into two types according to the etiopathogenic mechanism and insulin dependence. Type 1 diabetes (T1D), an insulin-dependent diabetes mellitus, is caused by damage and destruction of pancreatic β cells that produce insulin. It is a disease that is characterized by hyperglycemia and hypoinsulinemia. Aronia berry has been used as a medicinal food in Europe...
February 22, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29468360/bariatric-surgery-coverage-a-comprehensive-budget-impact-analysis-from-a-payer-perspective
#3
Swetha R Palli, John A Rizzo, Natalie Heidrich
OBJECTIVE: The objective of this study was to estimate a payer's budget impact of bariatric surgery coverage under (1) unrestricted, (2) budget-restricted ($500,000/year), and (3) quantity-restricted (100/year) medical benefit plan scenarios versus non-coverage in general and type 2 diabetes mellitus (T2DM) populations over a 10-year period. METHODS: Using recently published literature and health technology assessment reports, the model evaluated a hypothetical payer population of 100,000 members under current real-world trends: BMI-defined obesity groups (31...
February 21, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29466988/blood-flow-characteristics-of-diabetic-patients-with-complications-detected-by-optical-measurement
#4
Yuri An, Yujung Kang, Jungsul Lee, Chulwoo Ahn, Kihwan Kwon, Chulhee Choi
BACKGROUND: Diabetes mellitus (DM) is one of the most common diseases worldwide. Uncontrolled and prolonged hyperglycemia can cause diabetic complications, which reduce the quality of life of patients. Diabetic complications are common in DM patients. Because it is impossible to completely recover from diabetic complications, it is important for early detection. In this study, we suggest a novel method of determining blood flow characteristics based on fluorescence image analysis with indocyanine green and report that diabetic complications have unique blood flow characteristics...
February 21, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29466879/pituitary-adenylate-cyclase-activating-polypeptide-ameliorates-vascular-dysfunction-induced-by-hyperglycaemia
#5
Margit Solymar, Ivan Ivic, Marta Balasko, Balazs D Fulop, Gabor Toth, Andrea Tamas, Gyongyver Reman, Akos Koller, Dora Reglodi
BACKGROUND: Short-lasting hyperglycaemia occurs frequently in prediabetes and poorly controlled diabetes mellitus leading to vascular damage. Pituitary adenylate cyclase-activating polypeptide (PACAP) has been shown to play a protective role in vascular complications of diabetes; moreover, antioxidant effects of PACAP were also described. Therefore, we hypothesized that PACAP exerts protective effects in short-term hyperglycaemia-induced vascular dysfunctions. METHODS: After short-term hyperglycaemia, acetylcholine-induced and sodium nitroprusside-induced vascular relaxation of mouse carotid arteries were tested with a myograph with or without the presence of PACAP or superoxide dismutase...
February 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29465850/incorporating-oral-health-as-part-of-routine-diabetes-care-in-ireland
#6
J Aherne, O P Hamnvik, J Barrow, J Nunn
Diabetes mellitus is a common disorder of glucose metabolism that is increasingly prevalent in the Irish population. It is associated with a range of complications leading to substantial morbidity and mortality. A less well-recognized complication of diabetes is periodontal disease. This is a chronic inflammatory disease affecting the periodontium, the specialized group of tissues that surround and support the teeth, including the gingiva (gums) and alveolar bone. Periodontal disease affects patients with diabetes with a greater prevalence and incidence than non-diabetic patients, and can itself exert negative effects on glucose control in people with diabetes...
December 18, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/29465545/metformin-reduces-the-risk-of-cancer-in-patients-with-type-2-diabetes-an-analysis-based-on-the-korean-national-diabetes-program-cohort
#7
Hae Jin Kim, SooJin Lee, Ki Hong Chun, Ja Young Jeon, Seung Jin Han, Dae Jung Kim, Young Seol Kim, Jeong-Taek Woo, Moon-Suk Nam, Sei Hyun Baik, Kyu Jeung Ahn, Kwan Woo Lee
The epidemiological literature suggests that insulin resistance, hyperinsulinemia, and increased levels of insulin-like growth factors place patients with type 2 diabetes mellitus (T2DM) at greater risk of cancer. The association between cancer incidence and the use of antidiabetic medications in patients with T2DM has been recently examined. There have been conflicting reports regarding an association between metformin and cancer risk. The aim of this study was to investigate the relationship between metformin use and the incidence of cancer in Koreans with T2DM...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29465149/can-a-program-of-food-and-diabetes-education-improve-the-quality-of-the-lives-of-diabetic-patients-with-a-previous-myocardial-infarction
#8
A Tantucci, C Ripani, C Giannini, M Fregonese, M De Angelis
BACKGROUND AND OBJECTIVES: People with diabetes and cardiovascular complications need to be educated about the self-management of the disease at the time of diagnosis and during the follow-up to best benefit from what they learn. Education is most effective when offered to small groups of patients led by a professional team. The aim of the study is the evaluation of diabetes and food education aimed at improving the self-awareness of the disease, the management and the quality of the lives of diabetic patients with a previous myocardial infarction...
March 2018: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/29465053/erythropoietic-response-to-anaemia-of-dialysis-na%C3%A3-ve-patients-with-chronic-kidney-disease-in-zaria-north-west-nigeria
#9
L G Dogara, A Hassan, S Awwalu, L Okpetu, A D Waziri, A A Babadoko, I B Bosan, H M Muktar
Introduction: Chronic kidney disease (CKD) is a global health problem with an increasing prevalence worldwide. Anemia is one of its consistent and severe hematological complications although its mechanism is not fully elucidated. The primary defect could manifest as serum erythropoietin (sEPO) deficiency or EPO resistance. We set out to determine the erythropoietic response to anemia of patients with CKD and its relationship with their iron status in a cross-sectional descriptive study of 91 patients in various stages of CKD...
February 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29465046/clinical-and-laboratory-features-of-metformin-intoxication-in-suicidal-patients-attending-an-intensive-care-unit
#10
A Cetinkaya, D Avci, A Erden, O Akca, O Ozer, U Kalan, A I Gunal
Introduction: This study has been performed for the purpose of researching the complications occurred at patients who took metformin overdose in an attempt to suicide. None of the patients has the diagnosis of diabetes mellitus and never used metformin. Materials and Methods: This retrospective cross-sectional study was carried out with 21 patients who has neither diagnosed diabetes mellitus nor taken metformin for suicide before. Results: It was observed that there is a moderate, negative (r = -0...
February 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29464142/decreased-renal-function-is-associated-with-elevated-cha2ds2vasc-and-r2chads2-scores-in-non-valvular-atrial-fibrillation-patients-presenting-with-stroke
#11
Mohinder Vindhyal, Shravani R Vindhyal, Travis Haneke, Paul M Ndunda, Freidy Eid, K James Kallail
Introduction Atrial fibrillation (AF), the most common cardiac arrhythmia, affects approximately 2.3 million patients in the United States, costing around $26 billion. Atrial fibrillation is associated with a two- to seven-fold increased risk of stroke, one of the most serious complications. Chronic kidney disease affects approximately 13% of the US population and has been associated with higher rates of AF than the general population. In patients with chronic kidney disease (CKD), the risk of stroke increases as the glomerular filtration rate (GFR) decreases, especially in CKD stages three and four...
December 11, 2017: Curēus
https://www.readbyqxmd.com/read/29463026/the-nile-rat-arvicanthis-niloticus-as-a-superior-carbohydrate-sensitive-model-for-type-2-diabetes-mellitus-t2dm
#12
REVIEW
Avinaash Subramaniam, Michelle Landstrom, Alice Luu, K C Hayes
Type II diabetes mellitus (T2DM) is a multifactorial disease involving complex genetic and environmental interactions. No single animal model has so far mirrored all the characteristics or complications of diabetes in humans. Since this disease represents a chronic nutritional insult based on a diet bearing a high glycemic load, the ideal model should recapitulate the underlying dietary issues. Most rodent models have three shortcomings: (1) they are genetically or chemically modified to produce diabetes; (2) unlike humans, most require high-fat feeding; (3) and they take too long to develop diabetes...
February 18, 2018: Nutrients
https://www.readbyqxmd.com/read/29462628/term-small-for-gestational-age-infants-from-low-risk-women-are-at-significantly-greater-risk-of-adverse-neonatal-outcomes
#13
Jessie V Madden, Christopher J Flatley, Sailesh Kumar
BACKGROUND: Small-for-gestational age (SGA) infants (birthweight <10th centile) are at increased risk of perinatal complications but are frequently not identified antenatally, particularly in low risk women delivering at term (>37 weeks gestation). This is compounded by the fact that late pregnancy ultrasound is not the norm in many jurisdictions for this cohort of women. We thus investigated the relationship between birthweight <10th centile and serious neonatal outcomes in low risk women at term...
February 17, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29462515/risk-factor-for-diabetes-mellitus-and-high-blood-glucose-with-hmg-coa-reductase-inhibitors-using-a-postmarketing-surveillance-database-in-japan
#14
Masayuki Hashiguchi, Junya Maruyama, Mikiko Shimizu, Daichi Takahashi, Tsuyoshi Shiga
To investigate whether 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (statin) use is associated with an increased risk of diabetes mellitus and hyperglycemia, we performed a nested case-control study using a postmarketing surveillance database in Japan. The database cohort included 26,849 cases of statin use and 5308 cases of other lipid-lowering drug use in patients with hyperlipidemia. Participants received at least 1 type of statin, had a clear medication history of statin use, and had no complications of diabetes mellitus...
February 20, 2018: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29460260/clinical-benefit-of-basal-insulin-analogue-treatment-in-persons-with-type-2-diabetes-inadequately-controlled-on-prior-insulin-therapy-a-prospective-noninterventional-multicenter-study
#15
Jelica Bjekić-Macut, Teodora Beljić Živković, Radivoj Kocić
INTRODUCTION: Basal insulin analogues offer persons with type 2 diabetes mellitus (T2DM) adequate glycemic control combined with a favorable safety profile. BASAL-BALI-a prospective, noninterventional, multicenter disease registry-assessed the effectiveness and safety of basal insulin analogues in adult Serbians with T2DM previously inadequately controlled on other insulin types. METHODS: The primary objective was to assess the reduction in glycated hemoglobin (HbA1c ) from basal insulin analogue initiation to the end of a 6-month observation period...
February 19, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29460257/analysis-of-postprandial-glycemia-in-relation-to-metabolic-compensation-and-other-observed-parameters-of-outpatients-with-type-2-diabetes-mellitus-in-the-czech-republic
#16
Denisa Janíčková Žďárská, Martin Hill, Milan Kvapil, Pavlína Piťhová, Jan Brož
INTRODUCTION: The goal of the study was to determine the level of metabolic compensation expressed by glycosylated hemoglobin, fasting plasma glucose, and postprandial glucose as determined after a standardized breakfast; further, to evaluate interrelationships between the studied parameters and postprandial glucose levels. METHODS: The study included 1055 patients with type 2 diabetes mellitus. Their fasting plasma glucose and postprandial glucose were measured before and after a standardized breakfast...
February 19, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29459731/involvement-of-impaired-autophagy-and-mitophagy-in-neuro-2a-cell-damage-under-hypoxic-and-or-high-glucose-conditions
#17
Yufei Song, Yu Du, Wenying Zou, Yan Luo, Xiaojie Zhang, Jianliang Fu
Chronic cerebral hypoperfusion (CCH) plays an insidious role in the development of cognitive impairment. Considerable evidence suggests that Diabetes Mellitus (DM) as a vascular risk factor may exacerbate CCH and is closely related to cognitive decline. Dysregulation of autophagy is known to be associated with the pathogenesis of neurodegenerative diseases such as Alzheimer's disease. To elucidate the role of autophagy in CCH- and/or DM-related pathogenesis, mouse neuroblastoma Neuro-2a cells were exposed to hypoxia and/or high glucose for 48 h, mimicking CCH complicated with DM pathologies...
February 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29459599/erythrocyte-glucose-6-phosphate-dehydrogenase-level-in-type-2-diabetes-male
#18
A Khanam, Q S Akter, F Karim, M R Zannat
The patient with diabetes mellitus (DM) and its complication is increasing in our country and all over the world. There is also significant increase in the prevalence of erythrocyte glucose-6-phosphate dehydrogenase (eG6PD) deficiency in the men with longer duration of diabetes mellitus. To assess the eG6PD in type 2 diabetes male subjects to observe their enzyme status. This cross-sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka, Bangladesh from January 2011 to December 2011...
January 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29459362/cardiovascular-complications-in-pregnancy-it-is-time-for-action
#19
Cornelia R Graves, Stacy F Davis
Cardiovascular disease (CVD) is the leading cause of death during pregnancy, accounting for ≈33% of the maternal deaths in the United States.1 There is also increasing evidence that there is a significant link between complications of pregnancy and CVD later in life. Pregnancy complications such as preeclampsia, gestational diabetes mellitus, gestational hypertension, preterm delivery, and delivery of an infant with growth restriction provide signals about the mother's cardiovascular adaptability of physiological stress...
February 19, 2018: Circulation
https://www.readbyqxmd.com/read/29458435/long-term-effects-on-the-progress-of-neuropathy-after-diabetic-charcot-foot-an-8-5-year-prospective-case-control-study
#20
Rasmus Bo Jansen, Tomas Møller Christensen, Jens Bülow, Lene Rørdam, Per E Holstein, Ole Lander Svendsen
OBJECTIVE: Charcot foot is a severe complication to diabetes mellitus, associated with diabetic neuropathy. Any long-term effects of a Charcot foot on the progress of neuropathy are still largely unexplored. The objective was to investigate whether a previous Charcot foot had any long-term effects on the progress of neuropathy. RESULTS: An 8.5-year follow-up case-control study of 49 individuals with diabetes mellitus, 24 of whom also had Charcot foot at baseline visit in 2005-2007...
February 20, 2018: BMC Research Notes
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