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https://www.readbyqxmd.com/read/29792953/protective-effect-of-s-nitrosoglutathione-administration-against-hyperglycemia-induced-disruption-of-blood-brain-barrier-is-mediated-by-alterations-in-tight-junction-proteins-and-cell-adhesion-molecules
#1
Aanchal Aggarwal, Inderjit Singh, Rajat Sandhir
Diabetes is associated with increased blood brain barrier (BBB) permeability resulting in neurological deficits. The present study investigated the role of S-nitrosoglutathione (GSNO) on tight junction proteins and cell adhesion molecules in streptozotocin-induced diabetic mice. Diabetes was induced by intraperitoneal injection of streptozotocin (40 mg/kg body weight) for 5 days in mice. GSNO was administered daily (100 μg/kg body weight, orally) for 8 weeks after the induction of diabetes. A significant decline was observed in the cognitive ability of diabetic animals assessed using radial arm maze test...
May 21, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29792176/anti-neutrophil-cytoplasmic-antibody-associated-glomerulonephritis-with-detection-of-myeloperoxidase-and-phospholipase-a-2-receptor-in-membranous-nephropathy-lesions-report-of-two-patients-with-microscopic-polyangiitis
#2
Kenta Tominaga, Takahiro Uchida, Toshihiko Imakiire, Kenji Itoh, Hideyuki Shimazaki, Kuniaki Nakanishi, Hiroo Kumagai, Naoki Oshima
BACKGROUND: Podocyte phospholipase A2 receptor (PLA2 R) is a major target antigen in idiopathic adult membranous nephropathy (MN). Histological PLA2 R staining in the renal tissue has proven to be useful for the detection of idiopathic MN. However, glomerular PLA2 R deposits have also been recently observed in several patients with secondary MN, such as hepatitis B virus-associated, hepatitis C virus-associated, and neoplasm-associated MN. Certain inflammatory environments have been suggested to lead to abnormal expression of PLA2 R epitopes, with the resulting production of PLA2 R autoantibodies...
May 23, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29791294/a-survey-of-parasite-lesions-in-wild-red-deer-cervus-elaphus-from-argentina
#3
Elizabeth Chang Reissig, Adriana R Massone, Beatriz Iovanitti, Eduardo J Gimeno, Francisco A Uzal
In Argentina there is little information about diseases that affect exotic ungulates and the health risks that they pose to native wildlife, livestock, and humans. The aim of this study was to evaluate the health status of red deer ( Cervus elaphus) in the Nahuel Huapi National Park and surrounding areas in Patagonia, Argentina. During three consecutive hunting seasons, necropsies were performed on 101 red deer, and tissues were examined histologically. The most common lesions were those associated with hepatic and pulmonary parasites...
May 23, 2018: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29790662/pathogenic-characterization-of-porcine-reproductive-and-respiratory-syndrome-virus-of-indian-origin-in-experimentally-infected-piglets
#4
D Senthilkumar, K Rajukumar, A Sen, M Kumar, D Shrivastava, S Kalaiyarasu, S Gautam, F Singh, D D Kulkarni, V P Singh
Porcine reproductive and respiratory syndrome (PRRS) is an economically important transboundary viral disease of pigs confronting the swine industry worldwide. This study was aimed to assess the pathogenic potential of PRRS virus belonging to genotype 2 that emerged in India in 2013. Nine 6-week-old piglets were inoculated intranasally with 2 × 105.75  TCID50 /ml of PRRSV (Ind-297221/2013). Three piglets were kept as uninfected controls. Blood and nasal swabs were collected daily up to 7 days post-infection (dpi) and on alternate days subsequently...
May 23, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29790531/mechanism-of-h-adatoms-improving-the-o-2-reduction-reaction-on-the-zn-modified-anatase-tio-2-101-surface-studied-by-first-principles-calculation
#5
Liangliang Liu, Chongyang Li, Man Jiang, Xiaodong Li, Xiaowei Huang, Zhu Wang, Yu Jia
First principles calculations were performed to cast insight into the mechanism of the improvement of O2 reduction reaction (ORR) activity by Zn and H interstitials on the anatase TiO2 (101) surface. For the Zn-modified anatase TiO2 (101) surface, both surface and subsurface Zn interstitials could contribute to O2 adsorption and dissociation, but the dissociation barriers of O2 molecules are still too high, which limits the ORR activity. After a H adatom is introduced onto the Zn-modified anatase TiO2 (101) surface, the highest energy barriers are greatly reduced compared with those of the Zn-modified surface...
May 23, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29790291/the-eyes-have-it-a-rheumatologist-s-view-of-uveitis
#6
REVIEW
James T Rosenbaum, Andrew D Dick
Uveitis is defined as intraocular inflammation. It is an extra-articular manifestation of many forms of joint disease which include spondyloarthritis, juvenile idiopathic arthritis, and Behcet's disease. Rheumatologists may be asked to consult on patients with uveitis in order to identify an associated systemic illness. Diagnoses such as spndyloarthritis, sarcoidosis, and interstitial nephritis with uveitis are frequently overlooked by referring ophthalmologists. Alternatively rheumatologists may be asked to help manage the immunosuppression including biologics which can be required to treat a subset of patients with uveitis...
May 23, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29789836/lithium-effect-on-the-electronic-properties-of-porous-silicon-for-energy-storage-applications-a-dft-study
#7
I González, A N Sosa, A Trejo, M Calvino, A Miranda, M Cruz-Irisson
Theoretical studies on the effect of Li on the electronic properties of porous silicon are still scarce; these studies could help us in the development of Li-ion batteries of this material which overcomes some limitations that bulk silicon has. In this work, the effect of interstitial and surface Li on the electronic properties of porous Si is studied using the first-principles density functional theory approach and the generalised gradient approximation. The pores are modeled by removing columns of atoms of an otherwise perfect Si crystal, dangling bonds of all surfaces are passivated with H atoms, and then Li is inserted on interstitial positions on the pore wall and compared with the replacement of H atoms with Li...
May 23, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29789765/successful-salvage-treatment-of-refractory-recurrence-of-maxillary-sinus-carcinoma-using-image-guided-high-dose-rate-interstitial-brachytherapy
#8
Yin Zhang, Ning Wu, Zhipeng Zhao, Qianqian Chen, Guanghui Cheng
This case report illustrates a treatment effect of image-guided high-dose-rate (HDR) interstitial brachytherapy for refractory recurrence of maxillary sinus carcinoma. A 61-year-old male was previously admitted to another hospital and received surgery because of left maxillary sinus squamous cell carcinoma (SCC) 6 years ago. Tumor regrowth was noted 2 years after the initial radical surgery. The patient accepted local excision again for the recurrence, followed by external beam radiotherapy. Despite salvage treatment with surgery and external irradiation, the lesion expanded as 4...
April 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29789758/advantages-of-intraoperative-implant-for-interstitial-brachytherapy-for-accelerated-partial-breast-irradiation-either-frail-patients-with-early-stage-disease-or-in-locally-recurrent-breast-cancer
#9
Salvatore Cozzi, Maria Laplana, Dina Najjari, Andrea Slocker, Xavier Encinas, Joan Pera, Ferran Guedea, Cristina Gutierrez
Purpose: To describe the intraoperative multicatheter implantation technique for accelerated partial breast irradiation (APBI) delivered with high-dose-rate brachytherapy (HDR-BT). Secondarily, to evaluate outcomes and toxicity in a series of 83 patients treated with this technique at our institution. Material and methods: Retrospective analysis of a series of patients treated with HDR-BT APBI after intraoperative multicatheter interstitial implant between November 2006 and June 2017 at our institution...
April 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29789503/fully-ab-initio-determination-of-the-thermoelectric-properties-of-half-heusler-nitisn-crucial-role-of-interstitial-ni-defects
#10
Alexandre Berche, Philippe Jund
For thermoelectric applications, ab initio methods generally fail to predict the transport properties of the materials because of their inability to predict properly the carrier concentrations that control the electronic properties. In this work, a methodology to fill in this gap is applied on the NiTiSn half Heusler phase. For that, we show that the main defects act as donor of electrons and are responsible of the electronic properties of the material. Indeed, the presence of Nii interstitial defects explains the experimental valence band spectrum and its associated band gap reported in the literature...
May 23, 2018: Materials
https://www.readbyqxmd.com/read/29789431/clinical-and-pathology-findings-associate-consistently-with-larger-glomerular-volume
#11
Aleksandar Denic, Jerry Mathew, Venkata V Nagineni, R Houston Thompson, Bradley C Leibovich, Lilach O Lerman, John C Lieske, Mariam P Alexander, Joshua J Augustine, Walter K Kremers, Andrew D Rule
Background Glomerular volume increases when demand exceeds nephron supply, which may lead to glomerulosclerosis. It is unclear if determinants of glomerular volume are consistent between populations that differ by severity of comorbidities. Methods We studied kidney biopsy specimens from living kidney donors ( n =2453) and patients who underwent radical nephrectomy for a renal tumor ( n =780). We scanned specimen sections into high-resolution digital images, manually traced glomerular profiles, and calculated mean glomerular volumes using the Weibel-Gomez stereologic formula (separately for nonsclerosed glomeruli and globally sclerosed glomeruli)...
May 22, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29789305/ro-positive-interstitial-lung-disease-treated-with-cyclophosphamide
#12
Nader Habib Bedwani, Natasha Jefferson, Christopher Marguerie, Jayanta Mukherjee
Interstitial lung disease (ILD) comprises a spectrum of conditions involving inflammation and/or fibrosis of the alveolar wall causing limitation in gaseous exchange. Treatment varies depending on the underlying ILD. We describe the case of a woman presenting with a productive cough who was diagnosed with community-acquired pneumonia. While on the ward she developed type-1 respiratory failure requiring continuous positive airway pressure and intensive care unit admission. Failing to respond to targeted antimicrobials she was investigated by chest high-resolution CT and autoantibody screen to identify non-infective causes of her respiratory signs and symptoms...
May 22, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29789142/diffuse-idiopathic-pulmonary-neuroendocrine-cell-hyperplasia-report-of-two-cases
#13
Eva García-Fontán, Montserrat Blanco Ramos, Jose Soro García, Rommel Carrasco, Miguel Ángel Cañizares, Ana González Piñeiro
INTRODUCTION: Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare disorder characterized by a proliferation of neuroendocrine cells within the lung. It is classically described as a disease with persistent cough, dyspnea and wheezing in non-smoker middle aged females. CT of the chest reveals diffuse air trapping with mosaic pattern. PATIENTS AND METHODS: We present two cases of DIPNECH that were sent to our department to perform a lung biopsy with the diagnostic suspicion of diffuse interstitial disease...
May 19, 2018: Medicina Clínica
https://www.readbyqxmd.com/read/29789133/eosinophilic-pneumonia-induced-by-non-steroidal-anti-inflammatory-drugs-an-underestimated-risk
#14
François Krabansky, Brahim Azzouz, Josette Biya, Malak Abou Taam, Aurore Morel, Thierry Trenque
INTRODUCTION: Eosinophilic pneumonia (EP) is a rare but serious adverse drug reaction (ADR) induced by non-steroidal anti-inflammatory drugs (NSAIDs). METHODS: We describe the second published case of EP induced by oral diclofenac. We also reviewed the literature as well as French pharmacovigilance database. Case presentation A 63 year-old woman with polyarthralgia had taken diclofenac for three days for analgesic purposes. Progressively, the patient presented weakness, dyspnea and fever...
April 28, 2018: Thérapie
https://www.readbyqxmd.com/read/29788938/symptom-prevalence-of-patients-with-fibrotic-interstitial-lung-disease-a-systematic-literature-review
#15
Sabrina Carvajalino, Carla Reigada, Miriam J Johnson, Mendwas Dzingina, Sabrina Bajwah
BACKGROUND: Those affected by advanced fibrotic interstitial lung diseases have limited treatment options and in the terminal stages, the focus of care is on symptom management. However, quantitatively, little is known about symptom prevalence. We aimed to determine the prevalence of symptoms in Progressive Idiopathic Fibrotic Interstitial Lung Disease (PIF-ILD). METHODS: Searches on eight electronic databases including MEDLINE for clinical studies between 1966 and 2015 where the target population was adults with PIF-ILD and for whom the prevalence of symptoms had been calculated...
May 22, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29788800/relationship-between-ykl-40-and-pulmonary-arterial-hypertension-in-systemic-sclerosis
#16
Tetsuya Furukawa, Kiyoshi Matsui, Masayasu Kitano, Yuichi Yokoyama, Masahiro Sekiguchi, Naoto Azuma, Yasutomo Imai, Seiichi Hirota, Kiyofumi Yamanishi, Hajime Sano
OBJECTIVES: Systemic sclerosis (SSc) is an intractable connective tissue disease that causes skin and organ fibrosis. Interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH) affect its prognosis. YKL-40 protein impacts inflammation and tissue remodeling. Therefore, we evaluated the utility of YKL-40 blood levels in identifying patients with SSc complicated by PAH, as confirmed by immunohistochemistry (IHC) examination. METHODS: We retrospectively analyzed 78 patients with SSc and performed IHC on 7 normal and 7 SSc skin samples in the Japanese population...
May 23, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29788515/-survey-of-specialist-pulmonary-medicine-health-care-structures-for-patients-with-interstitial-lung-disease-in-nordrhein-westfalen-germany-a-pilot-project-of-the-western-german-respiratory-society-wdgp
#17
L Hagmeyer, P Haidl, M Westhoff, W Schulte, W Randerath, J Lorenz
AIM OF THE STUDY:  Survey of specialist pulmonary medicine health care structures for patients with interstitial lung disease (ILD) in Nordrhein-Westfalen, Germany. METHODS:  The Western German Respiratory Society initiated a voluntary registration of ILD expert centers. Structural quality and processes were evaluated by questionnaire. RESULTS:  49 centers were registered, 46 allowed analysis of their center data (15 pulmonology specialist practices, 34 hospital pulmonology departments)...
May 22, 2018: Pneumologie
https://www.readbyqxmd.com/read/29788503/visual-analogue-scales-for-interstitial-lung-disease-a-prospective-validation-study
#18
Helen Yates, Huzaifa I Adamali, Nick Maskell, Shaney Barratt, Charles Sharp
Rationale: Visual analogue scales (VAS) are simple symptom assessment tools which have not been validated in interstitial lung disease (ILD). Simple measures of ILD disease burden would be valuable for non-specialist clinicians monitoring disease away from ILD specialist centres. Objective: To validate VAS to assess change in dyspnoea, cough and fatigue in ILD, and to define the minimal clinically important difference (MCID) for change in these. Methods: 64 patients with ILD completed VAS for dyspnoea, cough and fatigue...
May 16, 2018: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29788462/clinicopathological-predictors-for-progression-of-chronic-kidney-disease-in-nephrosclerosis-a-biopsy-based-cohort-study
#19
Masayuki Yamanouchi, Junichi Hoshino, Yoshifumi Ubara, Kenmei Takaichi, Keiichi Kinowaki, Takeshi Fujii, Kenichi Ohashi, Koki Mise, Tadashi Toyama, Akinori Hara, Miho Shimizu, Kengo Furuichi, Takashi Wada
Background: Biopsy-based studies on nephrosclerosis are lacking and the clinicopathological predictors for progression of chronic kidney disease (CKD) are not well established. Methods: We retrospectively assessed 401 patients with biopsy-proven nephrosclerosis in Japan. Progression of CKD was defined as new-onset end-stage renal disease, decrease of estimated glomerular filtration rate (eGFR) by  ≥50% or doubling of serum creatinine, and the sub-distribution hazard ratio (SHR) with 95% confidence interval (CI) for CKD progression was determined for various clinical and histological characteristics in competing risks analysis...
May 19, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29788096/pnaktide-ameliorates-renal-interstitial-fibrosis-through-inhibition-of-sodium-potassium-adenosine-triphosphatase-mediated-signaling-pathways-in-unilateral-ureteral-obstruction-mice
#20
Xi Cheng, Yi Song, Yu Wang
Background: Sodium-potassium adenosine triphosphatase (Na/K-ATPase) has been shown to regulate Src activity by combining with Src to keep it in an inactive form. We previously reported that Na/K-ATPase was downregulated in unilateral ureteral obstruction (UUO) animals. In this study, we examined whether inhibition of Na/K-ATPase-mediated Src signaling pathways ameliorated renal interstitial fibrosis induced by UUO. Methods: UUO was performed on male C57BL/6J mice...
May 17, 2018: Nephrology, Dialysis, Transplantation
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