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https://www.readbyqxmd.com/read/29684926/changes-in-phase-angle-and-handgrip-strength-induced-by-suspension-training-in-older-women
#1
Francesco Campa, Analiza Mónica Silva, Stefania Toselli
This study aimed to present a suspension exercise training program suitable for older adults and to verify the effect of 12 weeks of training on handgrip strength (HS) and anthropometric and bioelectrical impedance parameters in older adults. Thirty older women (age 66.1±4.7 years, BMI 30.6±5.3 kg/m2 ) were randomly assigned to one of two groups: a training group (TG, n=15) or a control group (CG, n=15). The TG participated in a 12-week suspension training program, while the CG maintained their normal physical activity habits for the duration of the study...
April 23, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29684673/exercise-as-a-therapeutic-intervention-to-optimize-fetal-weight
#2
REVIEW
Laura M Reyes, Margie H Davenport
The Developmental Origins of Health and Disease suggest the in utero environment programs offspring obesity and cardiovascular disease. Therefore, there is a need to implement safe therapeutic interventions that do not involve the intake of medications or biological products during pregnancy that can improve maternal and fetal health. Prenatal exercise is established to promote maternal and fetal health. It is generally recommended that women accumulate at least 150 minutes per week of moderate-intensity exercise...
April 20, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29684558/effects-of-exercise-on-brown-and-beige-adipocytes
#3
REVIEW
Revati S Dewal, Kristin I Stanford
Physical exercise leads to beneficial effects in numerous tissues and organ systems and offers protection against obesity and type 2 diabetes. Recent studies have investigated the role of exercise on brown adipose tissue (BAT) and white adipose tissue (WAT), and have indicated marked adaptations to each tissue with exercise. Studies investigating the effects of exercise on BAT have produced conflicting results, with some showing an increase in the thermogenic activity of BAT and some demonstrating a decrease in the thermogenic activity of BAT...
April 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29684379/effect-of-a-long-term-treatment-with-metformin-in-dystrophic-mdx-mice-a-reconsideration-of-its-potential-clinical-interest-in-duchenne-muscular-dystrophy
#4
Paola Mantuano, Francesca Sanarica, Elena Conte, Maria Grazia Morgese, Roberta Francesca Capogrosso, Anna Cozzoli, Adriano Fonzino, Angelo Quaranta, Jean-Francois Rolland, Michela De Bellis, Giulia Maria Camerino, Luigia Trabace, Annamaria De Luca
The pharmacological stimulation of AMP-activated protein kinase (AMPK) via metabolic enhancers has been proposed as potential therapeutic strategy for Duchenne muscular dystrophy (DMD). Metformin, a widely-prescribed anti-hyperglycemic drug which activates AMPK via mitochondrial respiratory chain, has been recently tested in DMD patients in synergy with nitric oxide (NO)-precursors, with encouraging results. However, preclinical data supporting the use of metformin in DMD are still poor, and its actions on skeletal muscle appear controversial...
April 20, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29684218/what-is-the-evidence-for-a-role-for-diet-and-nutrition-in-osteoarthritis
#5
Sally Thomas, Heather Browne, Ali Mobasheri, Margaret P Rayman
As current treatment options in OA are very limited, OA patients would benefit greatly from some ability to self-manage their condition. Since diet may potentially affect OA, we reviewed the literature on the relationship between nutrition and OA risk or progression, aiming to provide guidance for clinicians. For overweight/obese patients, weight reduction, ideally incorporating exercise, is paramount. The association between metabolic syndrome, type-2 diabetes and OA risk or progression may partly explain the apparent benefit of dietary-lipid modification resulting from increased consumption of long-chain omega-3 fatty-acids from oily fish/fish oil supplements...
May 1, 2018: Rheumatology
https://www.readbyqxmd.com/read/29684190/can-online-social-support-be-detrimental-in-stigmatized-chronic-diseases-a-quadratic-model-of-the-effects-of-informational-and-emotional-support-on-self-care-behavior-of-hiv-patients
#6
Xunyi Wang, Srikanth Parameswaran, Darshan Mahendra Bagul, Rajiv Kishore
Objective: We studied the impact of online social support on patient self-care behavior in an online health community for human immunodeficiency virus (HIV) patients. We conceptualized emotional and informational support provided by community members into nuanced sub-dimensions. We explored how the direct and interaction effects of these sub-dimensions impact the self-care behavior of a support seeker. Methods: We used data from 330 255 posts in 30 050 threads from POZ, an online health community for HIV patients...
April 18, 2018: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29684136/effects-of-a-group-mediated-exercise-and-dietary-intervention-in-the-treatment-of-prostate-cancer-patients-undergoing-androgen-deprivation-therapy-results-from-the-idea-p-trial
#7
Brian C Focht, Alexander R Lucas, Elizabeth Grainger, Christina Simpson, Ciaran M Fairman, Jennifer M Thomas-Ahner, Jackie Buell, J Paul Monk, Amir Mortazavi, Steven K Clinton
Background: Although androgen-deprivation therapy (ADT) is the foundation of treatment for prostate cancer, the physiological impacts of ADT result in functional decline and enhanced risk of chronic disease and metabolic syndrome. Purpose: The Individualized Diet and Exercise Adherence Pilot Trial (IDEA-P) is a single-blind, randomized, pilot trial comparing the effects of a group-mediated, cognitive-behavioral (GMCB) exercise and dietary intervention (EX+D) with those of a standard-of-care (SC) control during the treatment of prostate cancer patients undergoing ADT...
April 19, 2018: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/29684090/predictors-of-poor-outcome-in-patients-with-pulmonary-arterial-hypertension-a-single-center-study
#8
Emilia Stepnowska, Ewa Lewicka, Alicja Dąbrowska-Kugacka, Ludmiła Daniłowicz-Szymanowicz, Paweł Zagożdżon, Rafał Kamiński, Zuzanna Lewicka-Potocka, Paweł Miękus, Dariusz Kozłowski, Wojciech Potocki, Grzegorz Raczak
OBJECTIVES: Pulmonary arterial hypertension (PAH) is a rare disorder with unfavorable prognosis despite implementation of specific PAH-oriented therapy. The aim of the study was to define predictors of poor prognosis in patients from one center treated according to the Polish National Health Fund program. PATIENTS AND METHODS: Forty-seven consecutive patients (30 women; aged 39±17 years) with PAH diagnosis were enrolled to the study. Clinical assessment, laboratory measurements, electrocardiogram, echocardiography, 6-minute walk test, 24-hour Holter monitoring, cardiopulmonary exercise test and microvolt T-wave alternans test were performed during routine visits...
2018: PloS One
https://www.readbyqxmd.com/read/29684047/effect-of-hypnotic-suggestion-on-knee-extensor-neuromuscular-properties-in-resting-and-fatigued-states
#9
Naiandra Dittrich, Daniel Agostino, Roberta Antonini Philippe, Luiz Guilherme A Guglielmo, Nicolas Place
PURPOSE: The aim of this study was to investigate whether hypnotic suggestions can alter knee extensor neuromuscular function at rest and during exercise. METHODS: Thirteen healthy volunteers (8 men and 5 women, 27 ± 3 years old) took part in this counterbalanced, crossover study including two experimental (hypnosis and control) sessions. Knee extensor neuromuscular function was tested before and after hypnosis suggestion by using a combination of voluntary contraction, transcutaneous femoral nerve electrical stimulation and transcranial magnetic stimulation (TMS)...
2018: PloS One
https://www.readbyqxmd.com/read/29683979/lifestyle-interventions-for-patients-with-nonalcoholic-fatty-liver-disease-a-network-meta-analysis
#10
Tian-Tian Zou, Chao Zhang, Yi-Fan Zhou, Yi-Jing Han, Jiao-Jiao Xiong, Xi-Xi Wu, Yong-Ping Chen, Ming-Hua Zheng
Lifestyle interventions remain the first-line therapy for nonalcoholic fatty liver disease (NAFLD). This study aims to evaluate the individual impact of exercise and/or dietary interventions on the level of alanine aminotransferase (ALT), aspartate aminotransferase (AST), homeostasis model of assessment for insulin resistance index (HOMA-IR), and BMI. Randomized-controlled trials from patients diagnosed with NAFLD were included in the meta-analysis if they reported the associations between changes in ALT, AST, HOMA-IR, or BMI and types of lifestyle interventions...
April 20, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29683926/heat-loss-is-impaired-in-older-men-on-the-day-following-prolonged-work-in-the-heat
#11
Sean R Notley, Robert D Meade, Andrew W DʼSouza, Brian J Friesen, Glen P Kenny
PURPOSE: Prolonged work in the heat may exacerbate the rise in core temperature on the next work day, especially in older workers who display impairments in whole-body heat loss that increase body heat storage and core temperature relative to young adults during heat stress. We therefore evaluated whether whole-body heat loss in older adults was impaired on the day following prolonged work in the heat. METHODS: Whole-body heat exchange and heat storage were assessed in nine older (53-64 years) males during three, 30-min bouts of semi-recumbent cycling at fixed rates of metabolic heat production (150 (Ex1), 200 (Ex2), 250 Wm (Ex3)), each separated by 15-min recovery, in hot-dry conditions (40°C, 20% relative humidity), immediately prior to (Day 1), and on the day following (Day 2), a prolonged, work simulation (~7...
April 21, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29683925/short-term-8-weeks-high-intensity-interval-training-in-diseased-cohorts
#12
James E M Blackwell, Brett Doleman, Philip J J Herrod, Samuel Ricketts, Bethan E Phillips, Jonathan N Lund, John P Williams
BACKGROUND & AIM: Exercise training regimes can lead to improvements in measures of cardiorespiratory fitness (CRF), improved general health, and reduced morbidity and overall mortality risk. High intensity interval training (HIIT) offers a time-efficient approach to improve CRF in healthy individuals, but the relative benefits of HIIT compared to traditional training methods are unknown in across different disease cohorts. METHODS: This systematic review and meta-analysis compares CRF gains in randomised controlled trials of short-term (<8 weeks) HIIT vs...
April 21, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29683923/effects-of-age-and-sex-on-inspiratory-muscle-activation-patterns-during-exercise
#13
Yannick Molgat-Seon, Paolo B Dominelli, Andrew H Ramsook, Michele R Schaeffer, Lee M Romer, Jeremy D Road, Jordan A Guenette, A William Sheel
PURPOSE: Characterize the effects of age, sex, and their interaction on inspiratory muscle activation patterns during exercise. METHODS: Twenty younger (20-30y, n=10 women) and twenty older (60-80y, n=10 women) subjects performed an incremental cycle exercise test. Electromyography of the scalene (EMGsca) and sternocleidomastoid (EMGscm) muscles were measured using skin surface electrodes, while diaphragm electromyography (EMGdi) and esophageal and transdiaphragmatic pressures were measured using an esophageal catheter...
April 21, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29683921/effects-of-exercise-on-asc-methylation-and-il-1-cytokines-in-heart-failure
#14
Brittany Butts, Javed Butler, Sandra B Dunbar, Elizabeth Corwin, Rebecca A Gary
INTRODUCTION/PURPOSE: Inflammation contributes to heart failure (HF) progression and the interleukin (IL)-1 cytokine IL-1β is implicated in this process. The adaptor protein ASC is necessary for inflammasome activation of IL-1β. Lower ASC methylation is associated with worse outcomes in HF. The purpose of this study was to examine the effects of exercise on changes in ASC methylation and activation of the interleukin-1 family cytokine IL-1β in persons with HF. METHODS: Participants (N=54) were randomized to receive exercise intervention (n=38) or attention control (n=16) for 3 months...
April 21, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29683919/hiit-in-the-real-world-outcomes-from-a-12-month-intervention-in-overweight-adults
#15
Melyssa Roy, Sheila M Williams, Rachel C Brown, Kim A Meredith-Jones, Hamish Osborne, Michelle Jospe, Rachael W Taylor
PURPOSE: Although high-intensity interval training (HIIT) and moderate-intensity continuous exercise have comparable health outcomes in the laboratory setting, effectiveness studies in real-world environments are lacking. The aim of this study was to determine the effectiveness of an unsupervised HIIT programme in overweight/obese adults over 12 months. METHODS: 250 overweight/obese adults could choose HIIT or current exercise guidelines of 30 minutes/day moderate-intensity exercise...
April 21, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29683913/acute-cardiometabolic-responses-to-a-novel-training-rope-protocol-in-children
#16
Avery D Faigenbaum, Jie Kang, Nicholas A Ratamess, Anne Farrell, Stephanie Golda, Andrew Stranieri, Jordan Coe, Jill A Bush
Faigenbaum, AD, Kang, J, Ratamess, NA, Farrell, A, Golda, S, Stranieri, A, Coe, J, and Bush, JA. Acute cardiometabolic responses to a novel training rope protocol in children. J Strength Cond Res 32(5): 1197-1206, 2018-The purpose of this study was to quantify the acute cardiometabolic responses to a novel training rope (TR) protocol in children. Fifteen boys (10.6 ± 1.4 years) were tested for peak oxygen uptake (V[Combining Dot Above]O2) on a treadmill and subsequently (2-7 days later) performed a progressive 10-minute protocol of 5 TR exercises (EX): EX1: standing side-to-side waves, EX2: seated alternating waves, EX3: standing alternating waves, EX4: jumping jacks, and EX5: double-arm slams...
May 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29683834/the-effect-of-preoperative-exercise-on-upper-extremity-recovery-following-breast-cancer-surgery-a-systematic-review
#17
Ajax Yang, Jonas Sokolof, Amitabh Gulati
Prehabilitation benefits among patients undergoing various oncological surgeries have been demonstrated. However, the effects of presurgical exercise and fitness on postoperative ipsilateral upper extremity recovery outcomes in patients with breast cancer surgery are less evident. A systematic review was performed to assess the effects of preoperative exercise and fitness on postmastectomy recovery. Systematic literature search was performed in 12 electronic databases. Study eligibility was accessed using the PICOS (Participants, Interventions, Comparison, Outcome and Study Design) criteria...
April 20, 2018: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/29683810/evidence-of-the-homeostatic-regulation-with-the-combination-of-transcranial-direct-current-stimulation-and-physical-activity
#18
Adriana Baltar, Fernanda Nogueira, Déborah Marques, Maíra Carneiro, Kátia Monte-Silva
Transcranial direct current stimulation (tDCS) can optimize beneficial effects induced by motor practice in patients with neurological disorders. However, possibly due to homeostatic regulation, the conditioning effects of tDCS are often imprecise and variable, limiting its therapeutic application. OBJECTIVE: to explore the magnitude and direction of the after-effects induced by physical activity (PA) on tDCS-preconditioned cortical excitability (CE). DESIGN: First, a crossover experiment was performed with 12 subjects to determine whether a single session of low-, moderate- and high-intensity PA on a treadmill modulates the motor cortical excitability measured by transcranial magnetic stimulation...
April 20, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29683771/wnt-signaling-related-osteokines-at-rest-and-following-plyometric-exercise-in-prepubertal-and-early-pubertal-boys-and-girls
#19
Panagiota Klentrou, Kirina Angrish, Nafisa Awadia, Nigel Kurgan, Rozalia Kouvelioti, Bareket Falk
PURPOSE: This study examined osteokines related to Wnt signaling at rest and in response to plyometric exercise in 12 boys [10.2 (0.4) y] and 12 girls [10.5 (0.4) y]. METHODS: One resting (preexercise) and 3 postexercise (5 min, 1 h, and 24 h) blood samples were analyzed for sclerostin, dickkopf-related protein 1 (DKK-1), osteoprotegerin (OPG), and receptor activator of nuclear factor kappa-β ligand (RANKL). RESULTS: Girls had higher resting sclerostin than boys [187...
April 23, 2018: Pediatric Exercise Science
https://www.readbyqxmd.com/read/29683765/modeling-cumulative-overall-prevention-efficacy-for-the-vrc01-phase-2b-efficacy-trials
#20
Yunda Huang, Shelly Karuna, Lindsay N Carpp, Daniel Reeves, Amarendra Pegu, Kelly Seaton, Kenneth Mayer, Joshua Schiffer, John Mascola, Peter B Gilbert
The Antibody Mediated Prevention trials are assessing whether intravenously-administered VRC01 (10 mg/kg or 30 mg/kg vs placebo) can prevent HIV infection. In a modeling exercise, we used two models to predict the overall prevention efficacy (PE) of each VRC01 dose in preventing HIV infection. For the first per-exposure PE model, parameters were estimated from studies where nonhuman primates (NHPs) were administered high-dose intra-rectal simian-human immunodeficiency virus challenge two days post-VRC01 infusion at various dosages ("NHP model")...
April 23, 2018: Human Vaccines & Immunotherapeutics
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