Eizoh Gondoh, Yusuke Hamada, Tomohisa Mori, Yusuke Iwazawa, Asami Shinohara, Michiko Narita, Daisuke Sato, Hiroyuki Tezuka, Takayasu Yamauchi, Mayu Tsujimura, Sara Yoshida, Kenichi Tanaka, Kensuke Yamashita, Haruka Akatori, Kimio Higashiyama, Kazuhiko Arakawa, Yukari Suda, Kanako Miyano, Masako Iseki, Eiichi Inada, Naoko Kuzumaki, Minoru Narita
BACKGROUND: It has been considered that activation of peripheral μ-opioid receptors (MORs) induces side effects of opioids. In this study, we investigated the possible improvement of the immune system in tumour-bearing mice by systemic administration of the peripheral MOR antagonist naldemedine. METHODS: The inhibitory effect of naldemedine on MOR-mediated signalling was tested by cAMP inhibition and β-arrestin recruitment assays using cultured cells. We assessed possible changes in tumour progression and the number of splenic lymphocytes in tumour-bearing mice under the repeated oral administration of naldemedine...
August 9, 2022: British Journal of Cancer